Mechanical force regulates the inhibitory function of PD-1.

Συγγραφείς: Chen H; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. cdchenhui@ibp.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. cdchenhui@ibp.ac.cn., Zhang Y; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, China., Cui L; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, China., Fan J; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the MOE Frontier Science Center for Brain Science & Brain-machine Integration, State Key Laboratory for Modern Optical Instrumentation Key Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China.; School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, China., Zhu H; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the MOE Frontier Science Center for Brain Science & Brain-machine Integration, State Key Laboratory for Modern Optical Instrumentation Key Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China.; China Resources Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen, 518000, China., Wu S; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China., Zhou H; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, China., Zhang Y; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, China., Song G; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, China., Jiang N; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA., Zhu M; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.; University of Chinese Academy of Sciences, Beijing, China., Lou C; Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, 150001, Heilongjiang, China. 601245@hrbmu.edu.cn., Chen W; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the MOE Frontier Science Center for Brain Science & Brain-machine Integration, State Key Laboratory for Modern Optical Instrumentation Key Laboratory for Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, Zhejiang, China. jackweichen@zju.edu.cn.; Zhejiang Laboratory for Systems and Precision Medicine, Zhejiang University Medical Center, Hangzhou, Zhejiang, China. jackweichen@zju.edu.cn., Lou J; State Key Laboratory of Epigenetic Regulation and Intervention, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. jlou@ibp.ac.cn.; University of Chinese Academy of Sciences, Beijing, China. jlou@ibp.ac.cn.

Πηγή: EMBO reports [EMBO Rep] 2026 Apr; Vol. 27 (7), pp. 1789-1812. Date of Electronic Publication: 2026 Feb 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Programmed Cell Death 1 Receptor*/metabolism , Programmed Cell Death 1 Receptor*/chemistry , Programmed Cell Death 1 Receptor*/genetics , B7-H1 Antigen*/metabolism , B7-H1 Antigen*/chemistry , B7-H1 Antigen*/genetics, T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Programmed Cell Death 1 Ligand 2 Protein/metabolism ; Programmed Cell Death 1 Ligand 2 Protein/chemistry ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; Animals

Involvement of the PD-1 pathway in the modulation of immune responses during allergic diseases.

Συγγραφείς: Mohamed AH; Al-Furat Al-Awsat Technical University, Technical College Al-Mussaib, Department of Optometry Techniques, Najaf, Iraq. asmaa.muhammed@atu.edu.iq., Al-Samawi RI; Department of Clinical Laboratory Sciences, College of Pharmacy, University of Al-Ameed, PO Box 198, Karbala, Iraq., Jamali MC; Department of Health and Laboratory Sciences, College of Medical and Health Sciences, Liwa University, Al Ain, Abu Dhabi, United Arab Emirates., Abdul-Jabbar Ali S; Al Safwa University College, Karbala, Iraq., Patel AA; Department of Clinical Biochemistry , College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia., Mustafa AEM; Department of Child Health, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.; Department of Pediatrics, Faculty of Medicine and Health Sciences, University of Kordofan, El Obeid, Sudan., Khairallah AS; Ophthalmology Department, King Khalid University, Abha, Kingdom of Saudi Arabia., Mansuri N; Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Kingdom of Saudi Arabia., Dutta AK; Department of Computer Science and Information Systems, College of Applied Sciences, AlMaarefa University, Ad Diriyah, Riyadh, 13713, Kingdom of Saudi Arabia., Sadikan MZ; Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Jalan Greentown, Ipoh, 30450, Perak, Malaysia., Mahmoud ZH; Chemistry Department, College of Sciences, University of Diyala, Diyala, Iraq.

Πηγή: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2026 Apr 01; Vol. 75 (1). Date of Electronic Publication: 2026 Apr 01.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9508160 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-908X (Electronic) Linking ISSN: 10233830 NLM ISO Abbreviation: Inflamm Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Programmed Cell Death 1 Receptor*/immunology , Hypersensitivity*/immunology, B7-H1 Antigen/immunology ; Programmed Cell Death 1 Ligand 2 Protein/immunology ; Humans ; Animals ; Signal Transduction

Chimeric PD‑1 receptor redirects primary T cells against childhood solid tumors but not to PD‑1 ligand‑positive CD80‑coexpressing cells.

Συγγραφείς: Shin C; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Imamura M; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Kasahara Y; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Suzuki Y; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Baba M; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Kubo N; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Hosokai R; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Iwabuchi H; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Murayama Y; Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Kawashima H; Division of Orthopedic Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Ogose A; Department of Orthopedic Surgery, Uonuma Kikan Hospital, Minamiuonuma, Niigata 949‑7302, Japan., Mihara K; International Center for Cell and Gene Therapy, Fujita Health University, Toyoake, Aichi 470‑1192, Japan., Saitoh A; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan., Imai C; Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Niigata 951‑8510, Japan.

Πηγή: Molecular medicine reports [Mol Med Rep] 2025 Sep; Vol. 32 (3). Date of Electronic Publication: 2025 Jul 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: D. A. Spandidos Country of Publication: Greece NLM ID: 101475259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-3004 (Electronic) Linking ISSN: 17912997 NLM ISO Abbreviation: Mol Med Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Neoplasms*/therapy , Neoplasms*/immunology , B7-H1 Antigen*/metabolism , B7-H1 Antigen*/immunology , Programmed Cell Death 1 Receptor*/immunology , Programmed Cell Death 1 Receptor*/genetics , Programmed Cell Death 1 Receptor*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , Receptors, Chimeric Antigen*/genetics , B7-1 Antigen*/metabolism , B7-1 Antigen*/immunology , B7-1 Antigen*/genetics, Immunotherapy, Adoptive/methods ; Programmed Cell Death 1 Ligand 2 Protein/immunology ; Programmed Cell Death 1 Ligand 2 Protein/metabolism ; Humans ; Child ; Female ; Male ; Cell Line, Tumor ; Child, Preschool

Single-cell transcriptomics reveal PD-1-loss-driven immune dysregulation of pulmonary lymphocytes during early Mycobacterium tuberculosis infection.

Συγγραφείς: Yang B; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China., Wang H; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China., Zhang S; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; College of Life Sciences and Technology, Huazhong Agricultural University, Wuhan, China., Cai J; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China., Cao G; Faculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China., Ma X; College of Agriculture, Ningxia University, Yinchuan, China., Dai J; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Πηγή: Microbiology spectrum [Microbiol Spectr] 2026 Sep; Vol. 14 (9), pp. e0119926. Date of Electronic Publication: 2026 Jul 24.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: ASM Press Country of Publication: United States NLM ID: 101634614 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2165-0497 (Electronic) Linking ISSN: 21650497 NLM ISO Abbreviation: Microbiol Spectr Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Programmed Cell Death 1 Receptor*/genetics , Programmed Cell Death 1 Receptor*/immunology , Programmed Cell Death 1 Receptor*/deficiency , Mycobacterium tuberculosis*/immunology , Mycobacterium tuberculosis*/genetics , Lung*/immunology , Lung*/microbiology , Tuberculosis*/immunology , Tuberculosis*/genetics , Tuberculosis*/microbiology , Lymphocytes*/immunology, B-Lymphocytes/immunology ; T-Lymphocytes, Regulatory/immunology ; Animals ; Mice ; Mice, Inbred C57BL ; Single-Cell Analysis ; Mice, Knockout ; Transcriptome ; T-Cell Exhaustion

Genetically proxied circulating PD-1/PD-L1 levels and broadly defined myocarditis: A bidirectional Mendelian randomization study with exploratory lipidomic analyses.

Συγγραφείς: Liu F; Department of Cardiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, China., Yang Q

Πηγή: Medicine [Medicine (Baltimore)] 2026 Aug 28; Vol. 105 (35), pp. e50475.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Myocarditis*/genetics , Myocarditis*/blood , Programmed Cell Death 1 Receptor*/blood , Programmed Cell Death 1 Receptor*/genetics , B7-H1 Antigen*/blood , B7-H1 Antigen*/genetics , Lipids*/blood, Humans ; Mendelian Randomization Analysis ; Genome-Wide Association Study ; Lipidomics ; Genetic Predisposition to Disease

For Advanced Oesophageal Squamous Cell Carcinoma, PD-1 Antibody Combined with Chemotherapy Improves Progression-Free Survival Compared with Monotherapy or Chemotherapy Alone as First-Line Treatment: A Retrospective Study with Prognostic Biomarker Analysis.

Συγγραφείς: Ju F; Department of Pharmaceutical Affairs Management, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214504, People's Republic of China., Ji Y; Department of General Surgery, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu, 214504, People's Republic of China.

Πηγή: Drug design, development and therapy [Drug Des Devel Ther] 2026 Aug 27; Vol. 20, pp. 600971. Date of Electronic Publication: 2026 Aug 27 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Comparative Study

Στοιχεία περιοδικού: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Esophageal Neoplasms*/drug therapy , Esophageal Neoplasms*/pathology , Esophageal Neoplasms*/diagnosis , Esophageal Squamous Cell Carcinoma*/drug therapy , Esophageal Squamous Cell Carcinoma*/diagnosis , Esophageal Squamous Cell Carcinoma*/pathology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology , Antibodies, Monoclonal, Humanized*/administration & dosage , Antibodies, Monoclonal, Humanized*/therapeutic use, Biomarkers, Tumor/blood ; Humans ; Retrospective Studies ; Male ; Female ; Progression-Free Survival ; Prognosis ; Middle Aged ; Aged ; Adult

Envafolimab - novel anti-PD-1/PD-L1 antibody in cancer treatment.

Συγγραφείς: Kciuk M; Department of Molecular Biotechnology and Genetics, University of Lodz, Lodz, Poland.; Department of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Kołat D; Department of Molecular Biotechnology and Genetics, University of Lodz, Lodz, Poland.; Department of Functional Genomics, Faculty of Medicine, Medical University of Lodz, Lodz, Poland., Wanke K; Department of Molecular Biotechnology and Genetics, University of Lodz, Lodz, Poland.; Doctoral School of Exact and Natural Sciences, University of Lodz, Lodz, Poland., Kontek R; Department of Molecular Biotechnology and Genetics, University of Lodz, Lodz, Poland.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Aug 05; Vol. 17, pp. 1918429. Date of Electronic Publication: 2026 Aug 05 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/drug therapy , Neoplasms*/immunology , Neoplasms*/metabolism , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology , B7-H1 Antigen*/antagonists & inhibitors , B7-H1 Antigen*/immunology , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/adverse effects , Immune Checkpoint Inhibitors*/pharmacology , Antibodies, Monoclonal, Humanized*/therapeutic use , Antineoplastic Agents, Immunological*/therapeutic use, Immunotherapy/methods ; Humans ; Animals

Regulation of PD-1 and PD-L1 expression in tumor immune microenvironment.

Συγγραφείς: Liu P; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Hepatobiliary Cancers, Nanjing, Jiangsu, China., Han G; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Hepatobiliary Cancers, Nanjing, Jiangsu, China., Chen Z; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Hepatobiliary Cancers, Nanjing, Jiangsu, China. Electronic address: zqchen@njmu.edu.cn., Wu J; Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Hepatobiliary Cancers, Nanjing, Jiangsu, China. Electronic address: wujindao@njmu.edu.cn.

Πηγή: Seminars in oncology [Semin Oncol] 2026 Aug; Vol. 53 (4), pp. 152522. Date of Electronic Publication: 2026 Jul 06.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0420432 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8708 (Electronic) Linking ISSN: 00937754 NLM ISO Abbreviation: Semin Oncol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Tumor Microenvironment*/immunology , Tumor Microenvironment*/genetics , B7-H1 Antigen*/genetics , B7-H1 Antigen*/metabolism , B7-H1 Antigen*/antagonists & inhibitors , B7-H1 Antigen*/immunology , Neoplasms*/immunology , Neoplasms*/drug therapy , Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/metabolism , Programmed Cell Death 1 Receptor*/genetics , Programmed Cell Death 1 Receptor*/metabolism , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology, Humans ; Gene Expression Regulation, Neoplastic ; Animals

Pharmacologic inhibition of SOX9-CDK4 by CYD-4-61 impairs gastric adenocarcinoma growth and amplifies anti-PD-1 response.

Συγγραφείς: Zou G; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Pharmacology, Toxicology and Neuroscience, LSU Health Shreveport, Shreveport, LA, USA., Yoshimura K; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan., Fan Y; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Pharmacy Practice and Translational Research, College of Pharmacy, University of Houston, Houston, TX, USA., Zeng L; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bhati AS; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vanpariya BR; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dai E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yamashita K; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang L; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wu J; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Shao S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Scott AW; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jin J; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pizzi MP; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yao X; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Brown CA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cao F; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang R; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Han X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li J; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Chen H; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Wang P; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu B; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhou J; Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA., Lo YH; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gan Q; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Waters R; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yin F; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Song S; Coriell Institute for Medical Research, NJ, USA., Ajani JA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: jajani@mdanderson.org., Dhar SS; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: ssdhar@mdanderson.org.

Πηγή: Cancer letters [Cancer Lett] 2026 Oct 28; Vol. 659, pp. 218777. Date of Electronic Publication: 2026 Aug 07.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/pathology , Stomach Neoplasms*/genetics , Stomach Neoplasms*/metabolism , SOX9 Transcription Factor*/antagonists & inhibitors , SOX9 Transcription Factor*/metabolism , SOX9 Transcription Factor*/genetics , Adenocarcinoma*/drug therapy , Adenocarcinoma*/pathology , Adenocarcinoma*/genetics , Adenocarcinoma*/metabolism , Cyclin-Dependent Kinase 4*/antagonists & inhibitors , Cyclin-Dependent Kinase 4*/metabolism , Cyclin-Dependent Kinase 4*/genetics , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/metabolism, Cell Proliferation/drug effects ; Apoptosis/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Signal Transduction/drug effects ; Animals ; Humans ; Mice ; Cell Line, Tumor ; Xenograft Model Antitumor Assays ; Female

The interplay of the lncRNA AFAP1-AS1 and the soluble immune checkpoint proteins sPD-1/sPD-L1 in breast cancer: tumor-immune cross-talk.

Συγγραφείς: AbdelHamid SG; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., El-Housseiny GS; Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt., AbdelAziz HM; Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Kamal AM; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Πηγή: Bioscience reports [Biosci Rep] 2026 Oct 21; Vol. 46 (10).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): RNA, Long Noncoding*/genetics , RNA, Long Noncoding*/blood , Breast Neoplasms*/genetics , Breast Neoplasms*/immunology , Breast Neoplasms*/blood , Breast Neoplasms*/pathology , Biomarkers, Tumor*/blood , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/immunology , B7-H1 Antigen*/blood , B7-H1 Antigen*/genetics , B7-H1 Antigen*/immunology , Programmed Cell Death 1 Receptor*/genetics , Programmed Cell Death 1 Receptor*/blood, Humans ; Female ; Gene Expression Regulation, Neoplastic ; Middle Aged ; Adult ; Case-Control Studies ; Tumor Escape

Latent effector capacity governs reversible T cell exhaustion: A theoretical mathematical model of PD-1 blockade response.

Συγγραφείς: Liew AY; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA., Li Y; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA., Dong H; Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA.; Department of Urology, Mayo Clinic, Rochester, MN, USA.

Πηγή: Science advances [Sci Adv] 2026 Oct 16; Vol. 12 (42), pp. eaei0840. Date of Electronic Publication: 2026 Oct 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Ιατρικοί όροι (MeSH): T-Cell Exhaustion*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/metabolism , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Models, Theoretical*, Neoplasms/immunology ; Neoplasms/drug therapy ; Humans ; Signal Transduction

Discovery of novel anthraquinone-based P2X7R antagonist that reinvigorates anti-tumor immunity and overcomes PD-1 resistance in breast cancer.

Συγγραφείς: Liang C; Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, 450018, China; School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, 450001, China., Wang S; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Pingyuan Laboratory, Zhengzhou, 450001, China., Liu X; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Pingyuan Laboratory, Zhengzhou, 450001, China., Wang X; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Pingyuan Laboratory, Zhengzhou, 450001, China., Yuan B; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Pingyuan Laboratory, Zhengzhou, 450001, China., Wang X; School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, 450001, China., Liu W; Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, 450018, China., Wang T; Beijing Children's Hospital, Capital Medical University, Beijing, China., Song C; College of Chemistry, Zhengzhou University, Zhengzhou, 450001, China; Pingyuan Laboratory, Zhengzhou, 450001, China. Electronic address: chjsong@zzu.edu.cn., Yao Y; School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, 450001, China; Pingyuan Laboratory, Zhengzhou, 450001, China; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: yongfangyao@zzu.edu.cn., Duan Y; Henan Provincial Key Laboratory of Pediatric Hematology, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, 450018, China; The Fifth Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, Henan, 450053, China. Electronic address: duanyongtao860409@163.com.

Πηγή: European journal of medicinal chemistry [Eur J Med Chem] 2026 Oct 05; Vol. 315, pp. 118924. Date of Electronic Publication: 2026 May 12.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/immunology , Breast Neoplasms*/metabolism , Receptors, Purinergic P2X7*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Anthraquinones*/pharmacology , Anthraquinones*/chemistry , Anthraquinones*/chemical synthesis , Purinergic P2X Receptor Antagonists*/pharmacology , Purinergic P2X Receptor Antagonists*/chemistry , Purinergic P2X Receptor Antagonists*/chemical synthesis , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/metabolism , Drug Resistance, Neoplasm*/drug effects , Drug Discovery*, Cell Proliferation/drug effects ; Humans ; Animals ; Female ; Mice ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Molecular Structure ; Dose-Response Relationship, Drug

Anti-PD-1/CTLA-4 bispecific antibody-based combination therapy for cervical cancer: a multicenter study with biomarker analysis.

Συγγραφείς: Li J; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China., Deng Y; Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, Changsha, China., Wu T; Department of Oncology, Changde Hospital, Xiangya School of Medicine, Changde, China., Xu C; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China., Zou W; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China., Yao J; Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China., Wang J; Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Oct 01; Vol. 17, pp. 1967065. Date of Electronic Publication: 2026 Oct 01 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Multicenter Study

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Uterine Cervical Neoplasms*/drug therapy , Uterine Cervical Neoplasms*/mortality , Uterine Cervical Neoplasms*/immunology , Uterine Cervical Neoplasms*/genetics , Uterine Cervical Neoplasms*/pathology , Antibodies, Bispecific*/therapeutic use , Antibodies, Bispecific*/adverse effects , Antibodies, Bispecific*/administration & dosage , Biomarkers, Tumor*/genetics , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology , CTLA-4 Antigen*/antagonists & inhibitors , CTLA-4 Antigen*/immunology , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/adverse effects, Humans ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Treatment Outcome ; Aged

Programmed cell death protein 1 (PD-1) regulates metabolic activity of regulatory T cells in ischemia-induced acute kidney injury.

Συγγραφείς: Pelletier OB; Center for Immunity, Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, United States., Dogan M; Center for Immunity, Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, United States., O'Neill C; Center for Immunity, Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, United States., Sabapathy V; Center for Immunity, Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, United States., Portilla D; Center for Immunity, Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, United States., Sharma R; Center for Immunity, Inflammation and Regenerative Medicine, Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA, United States.

Πηγή: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2026 Oct 01; Vol. 215 (10).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association of Immunologists Country of Publication: England NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): T-Lymphocytes, Regulatory*/immunology , T-Lymphocytes, Regulatory*/metabolism , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/etiology , Acute Kidney Injury*/immunology , Acute Kidney Injury*/pathology , Programmed Cell Death 1 Receptor*/genetics , Programmed Cell Death 1 Receptor*/metabolism , Reperfusion Injury*/immunology , Reperfusion Injury*/metabolism , Reperfusion Injury*/complications, Mitochondria/metabolism ; Kidney/pathology ; Kidney/immunology ; Animals ; Mice ; Mice, Knockout ; Oxidative Phosphorylation ; Mice, Inbred C57BL ; Male

Resistance to PD-1/PD-L1 blockade: Mechanism and pharmacological strategies.

Συγγραφείς: Kim AMJ; University of Chicago Medicine Comprehensive Cancer Center, 5841 S Maryland Ave, Chicago, IL 60637, USA; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA., Lee N; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA., Chen HY; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA., Lim SO; Borch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA; Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA. Electronic address: limsoe@purdue.edu.

Πηγή: Pharmacological research [Pharmacol Res] 2026 Oct; Vol. 232, pp. 108404. Date of Electronic Publication: 2026 Aug 18.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/drug therapy , Neoplasms*/immunology , Neoplasms*/metabolism , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , B7-H1 Antigen*/antagonists & inhibitors , B7-H1 Antigen*/immunology , Drug Resistance, Neoplasm*, Tumor Microenvironment/drug effects ; Humans ; Animals

Oncolytic virus-delivered CEACAM6/CD3 BiTEs combine with PD-1 blockade to achieve synergistic anticancer efficacy.

Συγγραφείς: Zhang W; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Department of Oncology, Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, Sichuan Province 610041, China., Dai S; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Fan H; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Yang N; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Xu L; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Liu Z; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Min Y; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Jiang Z; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Zhou L; Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Department of Neurosurgery, NHC Key Laboratory of Nuclear Technology Medical Transformation（Mianyang Central Hospital), School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan Province 621000, China., Yang H; Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China., Tong A; State Key Laboratory of Biotherapy and Cancer Center, Research Unit of Gene and Immunotherapy, Chinese Academy of Medical Sciences, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, Sichuan Province 610212, China. Electronic address: aipingtong@scu.edu.cn., Peng X; Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China; Nuclear Physics and Medical Research Key Laboratory of Sichuan Province, Sichuan University, Chengdu, Sichuan Province 610041, China. Electronic address: pxx2014@163.com.

Πηγή: Pharmacological research [Pharmacol Res] 2026 Oct; Vol. 232, pp. 108392. Date of Electronic Publication: 2026 Aug 13.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Oncolytic Virotherapy*/methods , Oncolytic Viruses*/genetics , CD3 Complex*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/immunology , Carcinoembryonic Antigen*/immunology , Immune Checkpoint Inhibitors*/therapeutic use , Immune Checkpoint Inhibitors*/pharmacology , Colonic Neoplasms*/therapy , Colonic Neoplasms*/immunology , Cell Adhesion Molecules*/immunology , Antibodies, Bispecific*, GPI-Linked Proteins/immunology ; GPI-Linked Proteins/antagonists & inhibitors ; T-Lymphocytes/immunology ; Simplexvirus/genetics ; Animals ; Female ; Humans ; Cell Line, Tumor ; Mice ; Mice, Inbred BALB C ; Tumor Microenvironment ; Antigens, CD

Development of therapeutic PD-1 monoclonal antibodies for treatment of canine tumor.

Συγγραφείς: He J; Laboratory of Molecular Virology & Immunology, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China., Yin X; Laboratory of Molecular Virology & Immunology, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China., Xie A; Laboratory of Molecular Virology & Immunology, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China., Wang N; Laboratory of Molecular Virology & Immunology, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China., Guo Z; Laboratory of Molecular Virology & Immunology, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China., Chen Y; College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China., Cui W; Haid Pet Care Co., Ltd, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China., Qian X; Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China., Pan C; Laboratory of Molecular Virology & Immunology, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou 511434, China. Electronic address: pancg01@Haid.com.cn.

Πηγή: Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 2026 Oct; Vol. 300, pp. 111189. Date of Electronic Publication: 2026 Aug 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Scientific Country of Publication: Netherlands NLM ID: 8002006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2534 (Electronic) Linking ISSN: 01652427 NLM ISO Abbreviation: Vet Immunol Immunopathol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Antibodies, Monoclonal*/therapeutic use , Antibodies, Monoclonal*/immunology , Programmed Cell Death 1 Receptor*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Neoplasms*/veterinary , Neoplasms*/drug therapy , Neoplasms*/immunology , Neoplasms*/therapy , Dog Diseases*/immunology , Dog Diseases*/drug therapy , Dog Diseases*/therapy, Immunotherapy/veterinary ; Enzyme-Linked Immunosorbent Assay/veterinary ; Animals ; Dogs ; Female

Emodinanthrone, a natural precursor of emodin, enhances T-cell anti-tumor via JAK3-STAT1/3 signal and improves anti-PD-1 efficacy against colon cancer.

Συγγραφείς: Dai Z; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China. Electronic address: daizhi@ynu.edu.cn., Liu FR; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China., Wang XH; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China., Xia M; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China., Yang MJ; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China., Zhao LX; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China., Zhao YL; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China., Luo XD; Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, Yunnan Key Laboratory of Research and Development for Natural Products, School of Pharmacy, Yunnan University, Kunming, 650500, PR China. Electronic address: xdluo@ynu.edu.cn.

Πηγή: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2026 Oct; Vol. 160, pp. 158639. Date of Electronic Publication: 2026 Jul 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Colonic Neoplasms*/drug therapy , Colonic Neoplasms*/pathology , Colonic Neoplasms*/immunology , T-Lymphocytes*/drug effects , T-Lymphocytes*/immunology , Programmed Cell Death 1 Receptor*/antagonists & inhibitors , Programmed Cell Death 1 Receptor*/metabolism , Emodin*/pharmacology, STAT1 Transcription Factor/metabolism ; Signal Transduction/drug effects ; Janus Kinase 3/metabolism ; STAT3 Transcription Factor/metabolism ; Lung Neoplasms/secondary ; Lung Neoplasms/drug therapy ; Animals ; Mice ; Humans ; Cell Line, Tumor ; Female

Targeting soluble PD-1 alleviates peritoneal fibrosis by modulating PD-L1 recycling and mesothelial-mesenchymal transition.

Συγγραφείς: Peng H; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Feng S; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Xiao K; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China; Grade 2021 Clinical Medicine (Five-Year Program), Basic Medical College, The Fourth Military Medical University, Xi'an, China., Li J; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Xu X; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Wu M; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Zhao F; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Zha Y; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Lu R; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Chen Y; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China., Yang G; Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China. Electronic address: yanggd@fmmu.edu.cn., Zhao Y; Department of Medical Microbiology and parasitology, The Fourth Military Medical University, Xi'an, China. Electronic address: zhaoya@fmmu.edu.cn., Zhang Y; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China. Electronic address: zhangyuting_51@163.com., He L; Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No.127, Changle West Road, Xi'an, 710032, China. Electronic address: helijie@fmmu.edu.cn.

Πηγή: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2026 Oct; Vol. 296, pp. 70-82. Date of Electronic Publication: 2026 Jul 14.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 101280339 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1810 (Electronic) Linking ISSN: 18781810 NLM ISO Abbreviation: Transl Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Peritoneal Fibrosis*/pathology , Peritoneal Fibrosis*/metabolism , Peritoneal Fibrosis*/blood , B7-H1 Antigen*/metabolism , Programmed Cell Death 1 Receptor*/blood , Programmed Cell Death 1 Receptor*/metabolism , Epithelial-Mesenchymal Transition*, Exosomes/metabolism ; Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; Peritoneal Dialysis ; Female

Absence of PD-1 expression on TFH and TFC cell subsets correlates with severity of multiple sclerosis.

Συγγραφείς: Lopes LMF; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Hygino J; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Cafasso MOS; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Sacramento PM; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Sales MC; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Kasahara TM; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Microbiology, University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Andrade RM; Department of General Medicine, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., de Souza Lopes LC; Post-graduate Program in Neurology and Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., de Azevedo CA; Post-graduate Program in Neurology and Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Vasconcelos CC; Post-graduate Program in Neurology and Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., de Melo Bento CA; Department of Microbiology and Parasitology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Post-graduate Program in Neurology and Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil; Department of General Medicine, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: cbento@unirio.br.

Πηγή: Journal of neuroimmunology [J Neuroimmunol] 2026 Oct; Vol. 419, pp. 579012. Date of Electronic Publication: 2026 Jun 27.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Programmed Cell Death 1 Receptor*/biosynthesis , Programmed Cell Death 1 Receptor*/metabolism , Multiple Sclerosis*/immunology , Multiple Sclerosis*/pathology , CD8-Positive T-Lymphocytes*/metabolism , CD8-Positive T-Lymphocytes*/immunology, Humans ; Male ; Female ; Adult ; Severity of Illness Index ; Middle Aged