Lecanemab promotes Fc receptor-dependent cell-mediated internalization and degradation of aggregated amyloid-beta in vitro and ex vivo

Authors: Fritz, Nicolas, Author, Johannesson, Malin, Author, Eriksson, Fredrik, Author, Osswald, Gunilla, Author, Lannfelt, Lars, Author, Möller, Christer, Author, Söderberg, Linda, Author

Contributors: Fritz, Nicolas, Author, Johannesson, Malin, Author, Eriksson, Fredrik, Author, Osswald, Gunilla, Author, Lannfelt, Lars, Author, Möller, Christer, Author, Söderberg, Linda, Author

Source: Neuroscience Letters. 882

Subject Terms: Alzheimer's disease, Lecanemab, Fc receptor, Immune cells, Lysosome, Postmortem human brain, Therapeutic antibody

File Description: electronic

Access URL: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-591774
https://doi.org/10.1016/j.neulet.2026.138645

Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain

Authors: Shah, Kinnary ¹, Totty, Michael S. ¹, Bach, Svitlana V. ^{2, 3}, Valentine, Madeline R. ², Chandra, Atharv ², AlGrain, Haya A. ², Divecha, Heena R. ^{2, 4}, Miller, Ryan A. ², Siewe, Felix Rene M. ², Kwon, Sang Ho ^{2, 4, 5}, Del Rosario Alvia, Ishbel ², Ramnauth, Anthony D. ^{2, 4}, Tippani, Madhavi ², Tyagi, Sanjana ², Kleinman, Joel E. ^{2, 3}, Collado-Torres, Leonardo ^{1, 2, 6}, Han, Shizhong ^{2, 3, 7}, Hyde, Thomas M. ^{2, 3, 8}, Page, Stephanie C. ^{2, 3}, Maynard, Kristen R. ^{2, 3, 4}, Hicks, Stephanie C. ^{1, 6, 9, 10, 12, ∗}, Martinowich, Keri ^{2, 3, 4, 11, 13, ∗∗}

Source: In Cell Reports 23 June 2026 45(6)

A practical workflow for fixation and autofluorescence reduction in correlative light and electron microscopy of postmortem human brain tissue

Authors: Lee, Ha-Eon ^{a, b, 1}, Kim, Hong Lim ^{c, 1}, Cho, Ara ^{a, d}, Kim, Do-Gyun ^{a, b}, Park, Min-Jin ^{a, b}, Oh, Yuna ^c, Park, Yong Soo ^{a, b}, Han, Rafael T. ^{e, f}, Lee, Mun‑Yong ^{a, b, ⁎, 2}, Riew, Tae-Ryong ^{a, b, ⁎, 2, 3}

Source: In Tissue and Cell April 2026 99

Integrated Investigation of Sex Differences in the Human Nociceptin/Orphanin FQ Receptor System: Postmortem Analyses and In Vivo [11C]NOP-1A Positron Emission Tomography Imaging

Authors: Dhaynaut, Maeva ^{a, ∗}, Morakabati, Neda R. ^b, Morris, Kiely ^b, Matuskey, David ^{a, c, d}, Guehl, Nicolas J. ^a, Himes, Michael L. ^e, El Fakhri, Georges ^{a, f}, Narendran, Rajesh ^{e, g}, Berretta, Sabina ^{b, h, †}, Normandin, Marc D. ^{a, †}, Pizzagalli, Diego A. ^{b, h, i, †}

Source: In Biological Psychiatry: Cognitive Neuroscience and Neuroimaging August 2026

Fronto-striatal molecular convergence in eating and obsessive-compulsive disorders

Authors: Glausier, Jill R. ^{1, 2, ⁎}

Source: In Trends in Neurosciences September 2026 49(9):701-702

Alcohol Use Disorder–Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex

Authors: White, Julie D. ^{a, ∗}, Minto, Melyssa S. ^a, Willis, Caryn ^a, Quach, Bryan C. ^a, Han, Shizhong ^b, Tao, Ran ^b, Deep-Soboslay, Amy ^b, Zillich, Lea ^c, Witt, Stephanie H. ^c, Spanagel, Rainer ^d, Hansson, Anita C. ^d, Clark, Shaunna L. ^e, van den Oord, Edwin J.C.G. ^f, Hyde, Thomas M. ^b, Mayfield, R. Dayne ^g, Webb, Bradley T. ^a, Johnson, Eric O. ^{a, h}, Kleinman, Joel E. ^b, Bierut, Laura J. ⁱ, Hancock, Dana B. ^a

Source: In Biological Psychiatry Global Open Science November 2024 4(6)

Neuroglia in suicide

Authors: Zhang, Lin, Swaab, Dick F.

Source: Handbook of Clinical Neurology ISBN: 9780443191022

Subject Terms: Mental Disorders, Postmortem human brain, Brain, Neuroglia/pathology, Astroglia, Oligodendroglia, Suicide, Mental Disorders/pathology, Humans, Animals, Brain/pathology, Microglia, Suicide/psychology, Neuroglia, Neuropsychiatric disorders

Access URL: https://pubmed.ncbi.nlm.nih.gov/40148056
https://hdl.handle.net/20.500.11755/aef60429-68dd-4c1a-a704-5f907bbbcdaf
https://doi.org/10.1016/B978-0-443-19102-2.00018-1
https://pure.knaw.nl/portal/en/publications/aef60429-68dd-4c1a-a704-5f907bbbcdaf

A manual multiplex immunofluorescence method for investigating neurodegenerative diseases

Authors: Ehrenberg, Alexander J, Morales, Dulce Ovando, Piergies, Antonia MH, Li, Song Hua, Tejedor, Jorge Santos, Mladinov, Mihovil, Mulder, Jan, Grinberg, Lea T

Source: Journal of Neuroscience Methods. 339

Subject Terms: 32 Biomedical and Clinical Sciences (for-2020), 3209 Neurosciences (for-2020), Biotechnology (rcdc), Neurosciences (rcdc), Neurodegenerative (rcdc), Antibodies (mesh), Antigens (mesh), Fluorescent Antibody Technique (mesh), Humans (mesh), Neurodegenerative Diseases (mesh), Staining and Labeling (mesh), Multiplex histology, Immunohistochemistry, Immunofluorescence, Neuropathology, Postmortem human brain tissue, Humans (mesh), Neurodegenerative Diseases (mesh), Antibodies (mesh), Antigens (mesh), Fluorescent Antibody Technique (mesh), Staining and Labeling (mesh), Immunofluorescence, Immunohistochemistry, Multiplex histology, Neuropathology, Postmortem human brain tissue, Antibodies (mesh), Antigens (mesh), Fluorescent Antibody Technique (mesh), Humans (mesh), Neurodegenerative Diseases (mesh), Staining and Labeling (mesh), 1109 Neurosciences (for), 1701 Psychology (for), 1702 Cognitive Sciences (for), Neurology & Neurosurgery (science-metrix), 3209 Neurosciences (for-2020)

File Description: application/pdf

Access URL: https://escholarship.org/uc/item/0p14m6q6
https://escholarship.org/content/qt0p14m6q6/qt0p14m6q6.pdf

PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer’s disease

Authors: Schröder, Sophie^Aff1, Fuchs, Ulrike^Aff1, Gisa, Verena^Aff1, Pena, Tonatiuh^{Aff1, Aff2}, Krüger, Dennis M.^{Aff1, Aff2}, Hempel, Nina^Aff1, Burkhardt, Susanne^Aff1, Salinas, Gabriela^Aff3, Schütz, Anna-Lena^Aff4, Delalle, Ivana^Aff5, Sananbenesi, Farahnaz^Aff4, Fischer, Andre^{Aff1, Aff6, Aff7, IDs0040102402787x_cor12}

Source: Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease. 148(1)

Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain

Authors: Schumann, Cynthia M, Sharp, Frank R, Ander, Bradley P, Stamova, Boryana

Source: Molecular Autism. 8(1)

Subject Terms: 5202 Biological Psychology (for-2020), 52 Psychology (for-2020), Brain Disorders (rcdc), Genetics (rcdc), Autism (rcdc), Women's Health (rcdc), Behavioral and Social Science (rcdc), Intellectual and Developmental Disabilities (IDD) (rcdc), Mental Health (rcdc), Estrogen (rcdc), Neurosciences (rcdc), Biotechnology (rcdc), 1.1 Normal biological development and functioning (hrcs-rac), Neurological (hrcs-hc), Mental health (hrcs-hc), Adolescent (mesh), Adult (mesh), Autism Spectrum Disorder (mesh), Child (mesh), Child, Preschool (mesh), Female (mesh), Gene Expression Profiling (mesh), Gene Expression Regulation (mesh), Humans (mesh), Male (mesh), MicroRNAs (mesh), Middle Aged (mesh), Oligonucleotide Array Sequence Analysis (mesh), RNA, Small Untranslated (mesh), Sex Characteristics (mesh), Young Adult (mesh), Autism, microRNA, small noncoding RNA, Superior Temporal Sulcus, Auditory cortex, Myelin, Oligodendrocytes, Sex, Sexual dimorphism, miR-181, miR-338, miR-219, miR-125, miR-448, Postmortem human brain, Humans (mesh), MicroRNAs (mesh), Oligonucleotide Array Sequence Analysis (mesh), Gene Expression Profiling (mesh), Gene Expression Regulation (mesh), Sex Characteristics (mesh), Adolescent (mesh), Adult (mesh), Middle Aged (mesh), Child (mesh), Child, Preschool (mesh), Female (mesh), Male (mesh), Young Adult (mesh), RNA, Small Untranslated (mesh), Autism Spectrum Disorder (mesh), Auditory cortex, Autism, Myelin, Oligodendrocytes, Postmortem human brain, Sex, Sexual dimorphism, Superior Temporal Sulcus, miR-125, miR-181, miR-219, miR-338, miR-448, microRNA, small noncoding RNA, Adolescent (mesh), Adult (mesh), Autism Spectrum Disorder (mesh), Child (mesh), Child, Preschool (mesh), Female (mesh), Gene Expression Profiling (mesh), Gene Expression Regulation (mesh), Humans (mesh), Male (mesh), MicroRNAs (mesh), Middle Aged (mesh), Oligonucleotide Array Sequence Analysis (mesh), RNA, Small Untranslated (mesh), Sex Characteristics (mesh), Young Adult (mesh), 1103 Clinical Sciences (for), 1109 Neurosciences (for), 3202 Clinical sciences (for-2020), 3209 Neurosciences (for-2020), 5202 Biological psychology (for-2020)

File Description: application/pdf

Access URL: https://escholarship.org/uc/item/4bb5p48s
https://escholarship.org/content/qt4bb5p48s/qt4bb5p48s.pdf

Optimization of measurement of mitochondrial electron transport activity in postmortem human brain samples and measurement of susceptibility to rotenone and 4-hydroxynonenal inhibition

Authors: Benavides, Gloria A. ^a, Mueller, Toni ^a, Darley-Usmar, Victor ^a, Zhang, Jianhua ^{a, b, ∗}

Source: In Redox Biology April 2022 50

Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding

Authors: Alegro, Maryana, Theofilas, Panagiotis, Nguy, Austin, Castruita, Patricia A, Seeley, William, Heinsen, Helmut, Ushizima, Daniela M, Grinberg, Lea T

Source: Journal of Neuroscience Methods. 282

Subject Terms: 32 Biomedical and Clinical Sciences (for-2020), 3209 Neurosciences (for-2020), Bioengineering (rcdc), Neurosciences (rcdc), Neurological (hrcs-hc), Alzheimer Disease (mesh), Brain (mesh), Cell Count (mesh), Fluorescent Antibody Technique (mesh), Humans (mesh), Image Processing, Computer-Assisted (mesh), Machine Learning (mesh), Microscopy, Fluorescence (mesh), Pattern Recognition, Automated (mesh), Reproducibility of Results (mesh), Dictionary learning, Sparse models, Image segmentation, Immunofluorescence, Postmortem human brain, Microscopy, Brain (mesh), Humans (mesh), Alzheimer Disease (mesh), Microscopy, Fluorescence (mesh), Fluorescent Antibody Technique (mesh), Cell Count (mesh), Reproducibility of Results (mesh), Image Processing, Computer-Assisted (mesh), Pattern Recognition, Automated (mesh), Machine Learning (mesh), Dictionary learning, Image segmentation, Immunofluorescence, Microscopy, Postmortem human brain, Sparse models, Alzheimer Disease (mesh), Brain (mesh), Cell Count (mesh), Fluorescent Antibody Technique (mesh), Humans (mesh), Image Processing, Computer-Assisted (mesh), Machine Learning (mesh), Microscopy, Fluorescence (mesh), Pattern Recognition, Automated (mesh), Reproducibility of Results (mesh), 1109 Neurosciences (for), 1701 Psychology (for), 1702 Cognitive Sciences (for), Neurology & Neurosurgery (science-metrix), 3209 Neurosciences (for-2020)

File Description: application/pdf

Access URL: https://escholarship.org/uc/item/8sx4j02b
https://escholarship.org/content/qt8sx4j02b/qt8sx4j02b.pdf

Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue

Authors: Christina V. Tauber, Sigrid C. Schwarz, Thomas W. Rösler, Thomas Arzberger, Steve Gentleman, Otto Windl, Mandy Krumbiegel, André Reis, Viktoria C. Ruf, Jochen Herms, Günter U. Höglinger

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)

Subject Terms: Parkinson’s disease, MAPT, Tau protein, H1 and H2 haplotype, Synucleins, Postmortem human brain, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/ae97f9d9d91942cbbbf9d8ff8dee7c6c

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

Authors: Bohan Zhu, Richard I Ainsworth, Zengmiao Wang, Zhengzhi Liu, Salvador Sierra, Chengyu Deng, Luis F Callado, J Javier Meana, Wei Wang, Chang Lu, Javier González-Maeso

Source: eLife, Vol 12 (2024)

Subject Terms: Schizophrenia, epigenetics, antipsychotics, aging, postmortem human brain, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/92393; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/3d93059727454ba289151c44ddd8e836

NEUROBIOLOGIA DEL SUICIDIO NEL DISTURBO DEPRESSIVO MAGGIORE: STUDIO MORFOLOGICO POST-MORTEM PER L¿INDAGINE DEL NETWORK GLIALE E VASCOLARE, CON ANALISI TOSSICOLOGICHE PER LA VALUTAZIONE DELL¿ADERENZA ALLA TERAPIA PSICHIATRICA

Authors: TAMBUZZI, STEFANO

Subject Terms: Suicide, Major Depressive Disorder (MDD), Glial cells (astrocytes and microglia), Neurovascular alterations, Postmortem human brain

File Description: application/pdf

Access URL: https://hdl.handle.net/2434/1205593

Adiponectin receptor2 and HCLS1 associated proteinX-1 levels are altered in postmortem schizophrenic brain

Authors: Sircar, Ratna ^{a, b, ⁎}, Belbin, Thomas J. ^{c, d}

Source: In Meta Gene February 2021 27

Histamine-4 receptor antagonist ameliorates Parkinson-like pathology in the striatum

Authors: Fang, Qiuyuan ^{a, 1}, Xicoy, Helena ^{b, c, 1}, Shen, Junqing ^a, Luchetti, Sabina ^{d, e}, Dai, Di ^f, Zhou, Pei ^{a, g}, Qi, Xin-Rui ^h, Martens, Gerard J.M. ^c, Huitinga, Inge ^{e, i}, Swaab, Dick F. ^d, Liu, Chunqing ^{a, ⁎}, Shan, Ling ^{d, ⁎}

Source: In Brain Behavior and Immunity February 2021 92:127-138

Regulation of cannabinoid CB1 and CB2 receptors, neuroprotective mTOR and pro-apoptotic JNK1/2 kinases in postmortem prefrontal cortex of subjects with major depressive disorder

Authors: Salort, Glòria ^{1, 2, a}, Hernández-Hernández, Elena ^{1, 2, a}, García-Fuster, M. Julia ^{1, 2}, García-Sevilla, Jesús A. ^{1, 2, ⁎}

Source: In Journal of Affective Disorders 1 November 2020 276:626-635

Proteomic dissection of Alzheimer’s disease pathology

Authors: Hondius, David Carolus

Source: Hondius, D C 2022, 'Proteomic dissection of Alzheimer’s disease pathology', Dr., Vrije Universiteit Amsterdam, s.l.

Subject Terms: Zs.liekte van Alzheimer, Proteomics, Cerebrale amyloïde angiopathie, Postmortaal menselijk brein, Biomarkers, Laserdissectie, Amyloïde bèta, Tau, Granulovacuolaire degeneratie, Alzheimer's disease, Cerebral amyloid angiopathy, Postmortem human brain, Laserdissection, Amyloid beta, Granulovacuolar degeneration

File Description: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13

Availability: https://research.vu.nl/en/publications/ae7045de-7b97-42dc-876f-405c3d4b1e13
https://hdl.handle.net/1871.1/ae7045de-7b97-42dc-876f-405c3d4b1e13
https://research.vu.nl/ws/files/149971235/D%20C%20%20Hondius%20-%20thesis.pdf
https://research.vu.nl/ws/files/149971237/D%20C%20%20Hondius%20-%20cover.pdf
https://research.vu.nl/ws/files/149971239/D%20C%20%20Hondius%20-%20toc.pdf
https://research.vu.nl/ws/files/149971241/D%20C%20%20Hondius%20-%20title_page.pdf

The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease

Alternate Title: Presynaptic Impairment in Alzheimer Disease (English)

Authors: Haytural, Hazal ^{‡, ‡‡‡}, Mermelekas, Georgios ^§, Emre, Ceren ^‡, Nigam, Saket Milind ^¶, Carroll, Steven L. ^‖, Winblad, Bengt ^{‡, **}, Bogdanovic, Nenad ^{**, ‡‡}, Barthet, Gaël ^{§§, ¶¶}, Granholm, Ann-Charlotte ^{‡, ‖‖}, Orre, Lukas M. ^§, Tjernberg, Lars O. ^‡, Frykman, Susanne ^‡

Source: In Molecular & Cellular Proteomics January 2020 19(1):128-141