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1Academic Journal
Συγγραφείς: Lebiecka-Johansen, Patrycja, Strom, Jesper, Mikkelsen, Kaare B, Cabrera, Alvaro F, Madsen, Rasmus E, Christensen, Julie A E, Hemmsen, Martin C, Kidmose, Preben
Πηγή: Lebiecka-Johansen, P, Strom, J, Mikkelsen, K B, Cabrera, A F, Madsen, R E, Christensen, J A E, Hemmsen, M C & Kidmose, P 2025, 'Benefits of Different Strategies to Adapt Sleep Scoring Models from Scalp-to Ear-EEG', Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), vol. 2025, pp. 1-7. https://doi.org/10.1109/EMBC58623.2025.11252780
Θεματικοί όροι: Male, Adult, Scalp, U-Sleep, Electroencephalography/methods, Polysomnography, Polysomnography/methods, Electroencephalography, Ear, Signal Processing, Computer-Assisted, automatic sleep scoring, ear-EEG, Sleep/physiology, Scalp/physiology, left-right mastoid, Humans, Female, Sleep, fine-tuning, ensemble prediction, Algorithms
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41336679
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2Academic Journal
Συγγραφείς: Hans Van Gorp, Merel M. van Gilst, Pedro Fonseca 0002, Fokke B. van Meulen, Johannes P. van Dijk, Sebastiaan Overeem, Ruud J. G. van Sloun
Πηγή: IEEE Journal of Biomedical and Health Informatics. 29:7186-7199
Θεματικοί όροι: Adult, Male, Signal Processing (eess.SP), FOS: Computer and information sciences, Computer Science - Machine Learning, Electroencephalography/methods, Polysomnography, Polysomnography/methods, Machine Learning (cs.LG), Young Adult, Computer-Assisted, Deep Learning, FOS: Electrical engineering, electronic engineering, information engineering, Humans, Score-based Diffusion Models, Electrical Engineering and Systems Science - Signal Processing, Electromyography, Electroencephalography, Signal Processing, Computer-Assisted, Bayes Theorem, Automatic Sleep Staging, Middle Aged, Generative AI, Diffusion Models, Signal Processing, Female, Sleep Stages, Sleep Stages/physiology, Electromyography/methods, Algorithms
Συνδεδεμένο Πλήρες ΚείμενοΣύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40293896
http://arxiv.org/abs/2408.15253
https://research.tue.nl/en/publications/9b47b724-8176-4053-9d9b-ff4b9265474a
https://doi.org/10.1109/JBHI.2025.3565034 -
3Academic Journal
Συγγραφείς: Songlu Lin, Zhihong Wang, Hans Van Gorp, Mengzhu Xu, Merel van Gilst, Sebastiaan Overeem, Jean-Paul Linnartz, Pedro Fonseca 0002, Xi Long 0001
Πηγή: IEEE Journal of Biomedical and Health Informatics. 29:6830-6843
Θεματικοί όροι: Adult, Male, N1 sleep, Neural Networks, adaptive loss function, Electroencephalography/methods, Polysomnography, Polysomnography/methods, Electroencephalography, Signal Processing, Computer-Assisted, pseudo-Siamese network, Computer, Young Adult, Sleep staging, Computer-Assisted, Deep Learning, Signal Processing, Humans, Female, Sleep Stages, Neural Networks, Computer, Sleep Stages/physiology, electroencephalography, Algorithms
Συνδεδεμένο Πλήρες ΚείμενοΣύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40408218
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4Academic Journal
Συγγραφείς: Pitkanen, Minna, Huovinen, Juho, Rissanen, Marika, Pitkanen, Henna, Kainulainen, Samu, Penzel, Thomas, Fanfulla, Francesco, Anttalainen, Ulla, Saaresranta, Tarja, Grote, Ludger, Hedner, Jan, Staats, Richard, Duce, Brett, Toyras, Juha, Oksenberg, Arie, Leppanen, Timo
Πηγή: J Clin Sleep Med
Journal of Clinical Sleep MedicineΘεματικοί όροι: Male, Adult, Sleep Apnea, arousal burden, Polysomnography, Supine Position/physiology, Polysomnography/methods, 32 Biomedical and Clinical Sciences, Obstructive/physiopathology, Sleep/physiology, polysomnography, Arousal/physiology, Supine Position, Humans, Sleep Apnea, Obstructive, sleep stage, Middle Aged, Scientific Investigations, sleeping position, arousal index, 3208 Medical physiology, Female, Sleep Stages, Sleep Stages/physiology, 3201 Cardiovascular medicine and haematology, Arousal, Sleep
Περιγραφή αρχείου: application/pdf
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5Academic Journal
Συγγραφείς: van der Aar, Jaap F., van Gilst, Merel M., van den Ende, Daan A., Fonseca, Pedro, van Wetten, Bregje N.J., Janssen, Hennie C.J.P., Peri, Elisabetta, Overeem, Sebastiaan
Πηγή: J Clin Sleep Med
Θεματικοί όροι: Sleep Wake Disorders/diagnosis, Male, Sleep Wake Disorders, Adult, single-channel, wearable EEG, Electroencephalography/methods, Polysomnography, Polysomnography/methods, Electroencephalography, transfer learning, Middle Aged, Scientific Investigations, Psychology/physiology, Transfer, Wearable Electronic Devices, sleep staging, Humans, sleep disorders, Female, Sleep Stages, Sleep Stages/physiology
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39347545
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6Book
Συγγραφείς: Gunasegarama, Mathushan, Dinesen, Birthe, Müller Larsen, Nikolaj, Ghamari Gilavai, Ghazal, Røge, Kristine, Kirk Østergaard, Mathias, Rovsing Jochumsen, Mads
Πηγή: Studies in Health Technology and Informatics ISBN: 9781643686295
Gunasegarama, M, Dinesen, B, Müller Larsen, N, Ghamari Gilavai, G, Røge, K, Kirk Østergaard, M & Rovsing Jochumsen, M 2025, Development of a Machine Learning Model for Screening Sleep Apnea in Heart Failure Patients Using Sleep Sensor Data. in Good Evaluation-Better Digital Health. vol. 332, IOS Press, Studies in Health Technology and Informatics, vol. 332, pp. 62-66, EFMI Special Topic Conference 2025, Osnabrück, Germany, 20/10/2025. https://doi.org/10.3233/SHTI251496Θεματικοί όροι: Heart Failure, Male, Sleep Apnea Syndromes/diagnosis, Polysomnography, Reproducibility of Results, Polysomnography/methods, Sensitivity and Specificity, Machine Learning, Diagnosis, Computer-Assisted/methods, Sleep Apnea Syndromes, Heart Failure/complications, Mass Screening/methods, Humans, Mass Screening, Female, Diagnosis, Computer-Assisted
Περιγραφή αρχείου: application/pdf
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7Academic Journal
Συγγραφείς: Lindstrom, Steven James, McDonald, Christine Faye, Howard, Mark Erskine, O'Donoghue, Fergal James, McMahon, Marcus Anthony, Rautela, Linda, Churchward, Thomas, Biesenbach, Peter, Rochford, Peter Douglas
Πηγή: Lindstrom, S J, McDonald, C F, Howard, M E, O'Donoghue, F J, McMahon, M A, Rautela, L, Churchward, T, Biesenbach, P & Rochford, P D 2024, 'Venous blood gases in the assessment of respiratory failure in patients undergoing sleep studies : a randomized study', Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, vol. 20, no. 8, pp. 1259-1266. https://doi.org/10.5664/jcsm.11128
Θεματικοί όροι: Male, Adult, Respiratory Insufficiency/blood, Polysomnography, Polysomnography/methods, mechanical ventilation, Veins, Carbon Dioxide/blood, arterial blood gases, polysomnography, Oxygen/blood, Humans, chronic respiratory failure, Blood Gas Analysis/methods, Aged, 2. Zero hunger, ventilation, Middle Aged, Carbon Dioxide, Hydrogen-Ion Concentration, 3. Good health, Oxygen, Veins/physiopathology, blood gas analysis, Female, Blood Gas Analysis, Respiratory Insufficiency
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38525926
https://pmc.ncbi.nlm.nih.gov/articles/PMC11294137/pdf/jcsm.11128.pdf
https://portal.findresearcher.sdu.dk/da/publications/98c6ba71-d226-44e1-ac70-a10f7f9b5ce3
https://doi.org/10.5664/jcsm.11128
https://portal.findresearcher.sdu.dk/da/publications/98c6ba71-d226-44e1-ac70-a10f7f9b5ce3
https://doi.org/10.5664/jcsm.11128 -
8Academic Journal
Συγγραφείς: van Gorp, Hans, van der Aar, Jaap F., van Sloun, Ruud J.G., Pijpers, Angelique, Fonseca, Pedro, Overeem, Sebastiaan, Van Gilst, Merel M.
Πηγή: van Gorp, H, van der Aar, J F, van Sloun, R J G, Pijpers, A, Fonseca, P, Overeem, S & Van Gilst, M M 2026, 'Automatic sleep staging and atonia detection in RBD using single-channel chin EMG', Journal of Parkinson's Disease, vol. 16, no. 6, pp. 1324-1335. https://doi.org/10.1177/1877718X261468531
Θεματικοί όροι: EMG, Parkinson's disease, RBD, REM sleep behavior disorder, REM sleep without atonia, RSWA, automatic sleep staging, deep learning, machine learning, surrogate sleep staging, Humans, Middle Aged, Electromyography/methods, Male, Polysomnography/methods, Chin, Sleep, REM/physiology, Muscle Hypotonia/diagnosis, Parkinson Disease/complications, REM Sleep Behavior Disorder/diagnosis, Signal Processing, Computer-Assisted, Female, Aged, Sleep Stages/physiology, /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being
Περιγραφή αρχείου: application/pdf
Relation: info:eu-repo/semantics/altIdentifier/pmid/42545038; info:eu-repo/semantics/altIdentifier/pissn/1877-7171; info:eu-repo/semantics/altIdentifier/eissn/1877-718X
Διαθεσιμότητα: https://research.tue.nl/en/publications/ac04e680-225e-4e73-9319-8100a0c5aeb9
https://doi.org/10.1177/1877718X261468531
https://pure.tue.nl/ws/files/421793893/van-gorp-et-al-2026-automatic-sleep-staging-and-atonia-detection-in-rbd-using-single-channel-chin-emg.pdf
https://www.scopus.com/pages/publications/105049595757 -
9Academic Journal
Συγγραφείς: Kuhn, Jasmin, Schiphorst, Laura R.B., Wulterkens, Bernice M., Asin, Jerryll, Overeem, Sebastiaan, van Gilst, Merel M., Fonseca, Pedro
Πηγή: Kuhn, J, Schiphorst, L R B, Wulterkens, B M, Asin, J, Overeem, S, van Gilst, M M & Fonseca, P 2026, 'Sleep apnea phenotypes based on multi-night assessment of sleep perception', Behavioral Sleep Medicine, vol. 24, no. 4, pp. 430-442. https://doi.org/10.1080/15402002.2026.2630936
Θεματικοί όροι: Humans, Female, Male, Phenotype, Middle Aged, Polysomnography/methods, Adult, Sleep Apnea, Obstructive/physiopathology, Sleep Duration, Sleep/physiology, Photoplethysmography/methods, Perception/physiology, Aged, Sleep Quality, Quality of Life
Περιγραφή αρχείου: application/pdf
Relation: info:eu-repo/semantics/altIdentifier/pmid/41689504; info:eu-repo/semantics/altIdentifier/pissn/1540-2002; info:eu-repo/semantics/altIdentifier/eissn/1540-2010
Διαθεσιμότητα: https://research.tue.nl/en/publications/7157ec5a-a9ce-47e3-8f3b-3301bc392017
https://doi.org/10.1080/15402002.2026.2630936
https://pure.tue.nl/ws/files/396042495/Sleep_apnea_phenotypes_based_on_multi-night_assessment_of_sleep_perception.pdf
https://www.scopus.com/pages/publications/105030191069 -
10Academic Journal
Πηγή: Home PSG Validation Study Consortium Group, Knoops-Borm, M A W, Vullings, R, Schneider, H & Overeem, S 2026, 'Leveraging Central Sleep Apnea Events to Validate the Measurement of Lung Volume Changes Using Thoracic Bio-Impedance', Sensors, vol. 26, no. 1, 12. https://doi.org/10.3390/s26010012
Θεματικοί όροι: Humans, Male, Female, Middle Aged, Lung/physiopathology, Electric Impedance, Adult, Lung Volume Measurements/methods, Sleep Apnea, Central/physiopathology, Body Mass Index, Polysomnography/methods, Thorax, lung volume, bioimpedance, central sleep apnea, bioz, thoracic, bio-impedance
Περιγραφή αρχείου: application/pdf
Relation: info:eu-repo/semantics/altIdentifier/pmid/41516450; info:eu-repo/semantics/altIdentifier/pissn/1424-8220
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11Academic Journal
Estimating the Severity of Obstructive Sleep Apnea Using ECG, Respiratory Effort and Neural Networks
Συγγραφείς: Pedro Fonseca 0002, Marco Ross, Andreas Cerny, Peter Anderer, Fons Schipper, Angela Grassi, Merel van Gilst, Sebastiaan Overeem
Πηγή: IEEE Journal of Biomedical and Health Informatics. 28:3895-3906
Θεματικοί όροι: Male, Adult, Sleep Apnea, Monitoring, Neural Networks, Electrocardiography/methods, electrocardiography, Polysomnography, Polysomnography/methods, Severity of Illness Index, Obstructive/physiopathology, Computer, Electrocardiography, Young Adult, 03 medical and health sciences, Computer-Assisted, 0302 clinical medicine, Humans, Biomedical measurement, obstructive sleep apnea, Aged, respiratory effort, Sleep Apnea, Obstructive, Sleep apnea, Signal Processing, Computer-Assisted, Middle Aged, Obstructive sleep apnea, 3. Good health, sleep staging, Recording, Signal Processing, Wearable sensors, Female, Neural Networks, Computer, Sleep Stages, Sleep Stages/physiology, artificial neural networks, Estimation, Algorithms
Συνδεδεμένο Πλήρες ΚείμενοΣύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38551823
https://research.tue.nl/en/publications/52e8a0c0-009b-4001-908f-a6eea3d7b835
https://doi.org/10.1109/JBHI.2024.3383240 -
12Academic Journal
Συγγραφείς: Hermans, Lieke, van Meulen, Fokke, Anderer, Peter, Ross, Marco, Cerny, Andreas, van Gilst, Merel, Overeem, Sebastiaan, Fonseca, Pedro
Πηγή: Journal of Clinical Sleep Medicine. 20:575-581
Θεματικοί όροι: Sleep Wake Disorders, home sleep monitoring, beta blockers, Polysomnography, Polysomnography/methods, automatic sleep staging, 3. Good health, Sleep/physiology, Humans, Sleep Stages, sleep, Sleep Stages/physiology, Sleep, cardiorespiratory signals, Retrospective Studies
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13Academic Journal
Συγγραφείς: van Doorn, Sander, Idema, Demy L, Heus, Pauline, Damen, Johanna Aag, Spijker,René, Japenga,Eva J, Reesink,Herre J, Hooft, Lotty, HAG Trombose, JC onderzoeksprogramma Cardiovascular Health, Team 5a, Epi Methoden Team 5, Epidemiology & Health Economics, JC onderzoeksprogramma Methodology
Θεματικοί όροι: Adult, Bias, Cardiovascular Diseases/epidemiology, Taverne, Quality of Life, Journal Article, Humans, Polysomnography/methods, Sleep Apnea, Obstructive/diagnosis, Review, Randomized Controlled Trials as Topic, Meta-Analysis
Περιγραφή αρχείου: text/plain
Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/466074
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14Academic Journal
Συγγραφείς: Reinke, Laurens, van der Heide, Esther M, Fonseca, Pedro, Absalom, Anthony R, Tulleken, Jaap E
Πηγή: Reinke, L, van der Heide, E M, Fonseca, P, Absalom, A R & Tulleken, J E 2025, 'Inter-rater disagreement in manual scoring of intensive care unit sleep data', BMC Research Notes, vol. 18, 138. https://doi.org/10.1186/s13104-025-07198-z
Θεματικοί όροι: Humans, Intensive Care Units, Polysomnography/methods, Female, Male, Middle Aged, Aged, Observer Variation, Critical Illness, Sleep Stages/physiology, Adult, Sleep/physiology
Περιγραφή αρχείου: application/pdf
Relation: info:eu-repo/semantics/altIdentifier/pmid/40170073; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/7cf62994-00ee-4940-b133-d9240febcfd9; info:eu-repo/semantics/altIdentifier/pissn/1756-0500
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15Academic Journal
Συγγραφείς: Alves, Raquel, van Meulen, Fokke, Overeem, Sebastiaan, Janssen, Hennie, van Hirtum, Pauline, Zinger, Svitlana, Stuijk, Sander
Πηγή: Alves, R, van Meulen, F, Overeem, S, Janssen, H, van Hirtum, P, Zinger, S & Stuijk, S 2025, 'Thermal Cameras for Overnight Measuring of Respiration in a Clinical Setting', Sensors, vol. 25, no. 19, 5956. https://doi.org/10.3390/s25195956
Θεματικοί όροι: Humans, Polysomnography/methods, Male, Adult, Respiration, Female, Respiratory Rate/physiology, Algorithms, Middle Aged, Sleep/physiology, Thermography/methods, Signal Processing, Computer-Assisted, Video Recording, Monitoring, Physiologic/methods, respiration rate, thermal cameras, sleep, polysomnography, remote thermography
Περιγραφή αρχείου: application/pdf
Relation: info:eu-repo/semantics/altIdentifier/pmid/41094778; info:eu-repo/semantics/altIdentifier/pissn/1424-8220
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16Academic Journal
Συγγραφείς: Bastien Poirson, Pierre Vandel, Hubert Bourdin, Silvio Galli
Πηγή: BMC Geriatr
BMC Geriatrics, Vol 24, Iss 1, Pp 1-12 (2024)
BMC geriatrics, vol. 24, no. 1, pp. 778Θεματικοί όροι: Male, Aged, 80 and over, Aging, Spindle, Research, Polysomnography, Sleep architecture, RC952-954.6, Age Factors, Humans, Aged, Retrospective Studies, Female, Polysomnography/methods, Sleep Stages/physiology, Aging/physiology, Sleep/physiology, Electroencephalography/methods, Oldest old, Electroencephalography, Geriatrics, Sleep Stages, Sleep
Περιγραφή αρχείου: application/pdf
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39304816
https://doaj.org/article/599758fa32264bab8520863c9dbf6ca2
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F2E93B0ABBFD6
https://serval.unil.ch/notice/serval:BIB_F2E93B0ABBFD
https://serval.unil.ch/resource/serval:BIB_F2E93B0ABBFD.P001/REF.pdf -
17Academic Journal
Συγγραφείς: Céline Labie, Nils Runge, Zosia Goossens, Olivier Mairesse, Jo Nijs, Anneleen Malfliet, Dieter Van Assche, Kurt de Vlam, Luca Menghini, Sabine Verschueren, Liesbet De Baets
Συνεισφορές: Physiotherapy, Human Physiology and Anatomy, Pain in Motion, Faculty of Physical Education and Physical Therapy, Brain, Body and Cognition, Faculty of Psychology and Educational Sciences, Doctoraatsbegeleiding, Brussels University Consultation Center, Psychology, Physical Medicine and Rehabilitation, Department of Bio-engineering Sciences
Πηγή: Sensors (Basel)
Θεματικοί όροι: DISORDER, Male, Adult, Technology, insomnia, Polysomnography, accuracy, knee osteoarthritis, polysomnography, sleep, wearable, Polysomnography/methods, 0805 Distributed Computing, 4606 Distributed computing and systems software, VALIDATION, Article, Analytical Chemistry, Sleep/physiology, Wearable Electronic Devices, Engineering, Sleep Initiation and Maintenance Disorders, Humans, Sleep Initiation and Maintenance Disorders/physiopathology, Instruments & Instrumentation, FIBROMYALGIA, Aged, Science & Technology, HIP, Osteoarthritis, Knee/physiopathology, 4008 Electrical engineering, Chemistry, Analytical, PAIN, Engineering, Electrical & Electronic, ADULTS, Middle Aged, Osteoarthritis, Knee, Chemistry, 0906 Electrical and Electronic Engineering, 4009 Electronics, sensors and digital hardware, Physical Sciences, Female, Sleep Stages, Sleep Stages/physiology, Sleep, 0301 Analytical Chemistry
Περιγραφή αρχείου: application/pdf
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40807979
https://lirias.kuleuven.be/handle/20.500.12942/770061
https://doi.org/10.3390/s25154813
https://biblio.vub.ac.be/vubir/(01d07148-cde8-4880-8417-2a6a53a4cb68).html -
18Academic Journal
Συγγραφείς: Deflandre, Eric, Cester, Luca, Degey, Stephanie V
Πηγή: Anesthesia & Analgesia. 132:1720-1726
Θεματικοί όροι: Adult, Male, Sleep Apnea, Obstructive, Anesthésie & soins intensifs, Polysomnography, Polysomnography/methods, Postoperative Complications/diagnosis, Sleep Apnea, Obstructive/diagnosis, Anesthesia & intensive care, Middle Aged, Sleep Apnea, Obstructive/physiopathology, Sciences de la santé humaine, Severity of Illness Index, Perioperative Care, 3. Good health, Perioperative Care/methods, 03 medical and health sciences, Anesthesiology and Pain Medicine, Postoperative Complications, 0302 clinical medicine, Humans, Female, Human health sciences, Postoperative Complications/physiopathology, Aged
Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/33721878
Συνδεδεμένο Πλήρες Κείμενο -
19Academic Journal
Συγγραφείς: Ai, Sizhi, Ye, Shuo, Li, Guohua, Leng, Yue, Stone, Katie L, Zhang, Min, Wing, Yun-Kwok, Zhang, Jihui, Liang, Yannis Yan
Πηγή: Ai, S, Ye, S, Li, G, Leng, Y, Stone, K L, Zhang, M, Wing, Y-K, Zhang, J & Liang, Y Y 2024, 'Association of Disrupted Delta Wave Activity During Sleep With Long-Term Cardiovascular Disease and Mortality', Journal of the American College of Cardiology, vol. 83, no. 17, pp. 1671-1684. https://doi.org/10.1016/j.jacc.2024.02.040
Θεματικοί όροι: Humans, Male, Cardiovascular Diseases/mortality, Middle Aged, Female, Polysomnography/methods, Aged, Delta Rhythm/physiology, Follow-Up Studies, Sleep/physiology
Relation: info:eu-repo/semantics/altIdentifier/pmid/38573282; info:eu-repo/semantics/altIdentifier/pissn/0735-1097
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20Academic Journal
Συγγραφείς: Braun, Sina, Laemmer, Constanze, Schulte, Sandra, Gohlke, Bettina
Πηγή: http://lobid.org/resources/99370675069506441#!, 19(1):461.
Θεματικοί όροι: COVID-19, Adolescent [MeSH], Female [MeSH], Polysomnography/methods [MeSH], COVID-19 sequelae, Prader-Willi Syndrome/physiopathology [MeSH], Adult [MeSH], Polysomnography, Humans [MeSH], Longitudinal Studies [MeSH], Retrospective Studies [MeSH], Prader-Willi syndrome, Male [MeSH], Research, Long COVID, Young Adult [MeSH], COVID-19/epidemiology [MeSH], Child [MeSH], SARS-CoV-2 [MeSH], Child, Preschool [MeSH]
Relation: https://repository.publisso.de/resource/frl:6523214; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639118/