BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL

Συγγραφείς: Santosh K Gothwal, Ahmed Refaat, Mikiyo Nakata, Andre Stanlie, Tasuku Honjo, Noorzahan Begum

Πηγή: Nucleic Acids Res

Θεματικοί όροι: 0301 basic medicine, Cell biology, DNA End-Joining Repair, DNA Repair, Molecular biology, DNA mismatch repair, DNA repair, Cell Cycle Proteins, Chimeric Antigen Receptor T Cell Therapy, Plant Science, Protein Serine-Threonine Kinases, Gene, Agricultural and Biological Sciences, BRCA1/2 Deficiency, Mice, Bromodomain Containing Proteins, 03 medical and health sciences, Health Sciences, Genetics, Animals, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, DNA Breaks, Double-Stranded, Molecular Biology, Biology, Antibody, Recombination, Genetic, B-Lymphocytes, 0303 health sciences, B cell, DNA repair protein XRCC4, Nuclear Proteins, Life Sciences, Immunoglobulin class switching, DNA, Immunoglobulin Class Switching, V(D)J recombination, Recombination, 3. Good health, Oncology, FOS: Biological sciences, Viral RNA Silencing and Plant Immunity, Medicine, Non-homologous end joining, Transcription Factors

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38567724

BRCA mutation in Vietnamese prostate cancer patients: a mixed cross-sectional study and case series

Συγγραφείς: Phuong Cam Pham, Tan Phat Pham, Long Doan Dinh, Loi Thuan Nguyen, Nam Nguyen Hai Le, Mark T. Bui, Hung Quang Nguyen, Tuyen Van Pham, Quoc-Hoang-Quyen Vo, Thi-Hong-Ha Vu, Hien Thu Thi Vu, Ngoc Bich Thi Le, Bùi Hữu Hoàng, Anh Lan Thi Luong, Hoai Thi Nguyen, Ly Thi Khanh Nguyen, Thong Le Minh Pham, Thuy Phuong Ngo, Hien Minh Nguyen, Tran Ngoc Dang, Vien Truong Nguyen, Khoa Trong

Πηγή: Oncologie. 26:247-256

Θεματικοί όροι: Vietnamese, Pathology and Forensic Medicine, Molecular Characterization of Colorectal Cancer, Breast cancer, Biochemistry, Genetics and Molecular Biology, Health Sciences, Genetics, Series (stratigraphy), Pathology, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Genetic Research on BRCA Mutations and Cancer Risk, Internal medicine, Biology, Cross-sectional study, Cancer, Prostate cancer, BRCA mutation, Life Sciences, Paleontology, Linguistics, BRCA1, BRCA2, FOS: Philosophy, ethics and religion, 3. Good health, Philosophy, Oncology, Gynecology, FOS: Biological sciences, FOS: Languages and literature, Medicine

Modulation of Apoptotic and Akt/PI3K/mTOR pathways to target Glioblastoma Cells using synthetic compound PGEA-AN

Συγγραφείς: Shafea Saad, Farina Hanif, Shabana Usman Simjee, Shaheen Faizi, Lubna Khan, Ambreen Ashfaque

Πηγή: Journal of the Pakistan Medical Association, Vol 74, Iss 2 (2024)

Θεματικοί όροι: Financial economics, Molecular biology, Economics, Biological Activities of Diterpenoids from Medicinal Plants, Apoptosis, Cancer research, Biochemistry, Phosphatidylinositol 3-Kinases, Synthesis, Cell growth, In vitro, Protein kinase B, Cell Line, Tumor, Biochemistry, Genetics and Molecular Biology, Health Sciences, Temozolomide, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Molecular Biology, Biology, Cell Proliferation, Programmed cell death, Pharmacology, Caspase 3, TOR Serine-Threonine Kinases, Life Sciences, 3. Good health, Chemistry, Proto-Oncogene Proteins c-bcl-2, Oncology, Derivative (finance), PI3K/AKT/mTOR pathway, Medicine, Diterpenes, Glioblastoma, Proto-Oncogene Proteins c-akt, Signal Transduction

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38385470
https://doaj.org/article/f26e47b423f449be9c32e29e590d23a3

Promising 8-Aminoquinoline-Based Metal Complexes in the Modulation of SIRT1/3-FOXO3a Axis against Oxidative Damage-Induced Preclinical Neurons

Συγγραφείς: Waralee Ruankham, Napat Songtawee, Veda Prachayasittikul, Apilak Worachartcheewan, Wilasinee Suwanjang, Ratchanok Pingaew, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin

Πηγή: ACS Omega
ACS Omega, Vol 8, Iss 49, Pp 46977-46988 (2023)

Θεματικοί όροι: Pharmacology, Lysosomal Calcium Signaling in Physiology and Pathology, Pharmacophore, Physiology, Life Sciences, Nicotinic Acid Adenine Dinucleotide Phosphate, Biochemistry, Neuroprotection, 3. Good health, Chemistry, Oncology, Oxidative stress, FOS: Biological sciences, Biochemistry, Genetics and Molecular Biology, Role of Sirtuins in Health and Aging, Health Sciences, Medicine, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Oxidative phosphorylation, Geriatrics and Gerontology, QD1-999, Biology

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38107906
https://doaj.org/article/5c2f626ad6eb468c918b3690fa013365

Targeting MALAT1 Augments Sensitivity to PARP Inhibition by Impairing Homologous Recombination in Prostate Cancer

Συγγραφείς: Anjali Yadav, Tanay Biswas, Ayush Praveen, Promit Ganguly, Ankita Bhattacharyya, Ayushi Verma, Dipak Datta, Bushra Ateeq

Πηγή: Cancer Res Commun

Θεματικοί όροι: Male, Pulmonary and Respiratory Medicine, Cancer Research, Synthetic lethality, DNA repair, Role of Long Noncoding RNAs in Cancer and Development, Cancer research, Poly(ADP-ribose) Polymerase Inhibitors, Adenocarcinoma, Chromoplexy, PARP1, Gene, Mice, Advancements in Prostate Cancer Research, Biochemistry, Genetics and Molecular Biology, Health Sciences, Genetics, Humans, Animals, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Metastatic Prostate Cancer, Homologous recombination, Homologous Recombination, MALAT1, Biology, Cancer, Prostate cancer, Prostate, Life Sciences, 3. Good health, PARP Inhibitors, Prostatic Neoplasms, Castration-Resistant, MicroRNAs, Oncology, FOS: Biological sciences, Long non-coding RNA, Medicine, RNA, RNA, Long Noncoding, PCA3, Poly ADP ribose polymerase, Polymerase, Research Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37812088

Adenosine receptor A2b confers ovarian cancer survival and PARP inhibitor resistance through IL‐6‐STAT3 signalling

Συγγραφείς: Li Na, Lin Huan, Chunyan Zhang, Hanming Wang, Junxi Lu

Πηγή: J Cell Mol Med

Θεματικοί όροι: STAT3 Transcription Factor, Physiology, Antineoplastic Agents, Cancer research, Poly(ADP-ribose) Polymerase Inhibitors, Biochemistry, Gene, Olaparib, Ovarian cancer, Cell Line, Tumor, Biochemistry, Genetics and Molecular Biology, Health Sciences, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Biology, Internal medicine, Cancer, Ovarian Neoplasms, Lysosomal Calcium Signaling in Physiology and Pathology, Interleukin-6, Receptors, Purinergic P1, Life Sciences, Original Articles, 3. Good health, PARP Inhibitors, PARP inhibitor, Oncology, Genomic Studies and Treatment of Ovarian Carcinoma, Reproductive Medicine, FOS: Biological sciences, Phthalazines, Medicine, Female, Poly ADP ribose polymerase, Neoplasm Recurrence, Local, Polymerase

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37278400

Efficacy and safety of maintenance therapy with pamiparib versus placebo for advanced gastric cancer responding to first‐line platinum‐based chemotherapy: Phase 2 study results

Συγγραφείς: Fortunato Ciardiello, Yung‐Jue Bang, Andrés Cervantes, Mikhail Dvorkin, Charles D. Lopez, Jean‐Philippe Metges, Antonio Ruíz, Mariona Calvo, Andrew Strickland, George Kannourakis, Kei Muro, Hisato Kawakami, Wei Jia, Christophe Borg, Zhengyuan Zhu, Neal Gupta, Robert J. Pelham, Lin Shen

Πηγή: Cancer Med
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Cancer Medicine
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Cancer Medicine, Vol 12, Iss 12, Pp 13145-13154 (2023)

Θεματικοί όροι: Pulmonary and Respiratory Medicine, Alternative medicine, Organic chemistry, Phase (matter), poly(ADP-ribose) polymerase inhibitors, clinical trial, gastric cancer, maintenance, phase 2, RESEARCH ARTICLES, Double-Blind Method, Stomach Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Health Sciences, Pathology, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Chemotherapy, Internal medicine, RC254-282, Placebo, Platinum, Cancer, Fluorenes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Gastric Cancer Research and Treatment, Progression-Free Survival, 3. Good health, PARP Inhibitors, First line, Chemistry, Oncology, Genomic Studies and Treatment of Ovarian Carcinoma, Reproductive Medicine, poly(ADP‐ribose) polymerase inhibitors, Phases of clinical research, Medicine, Cancer Therapy, Maintenance therapy

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37260158
https://hdl.handle.net/20.500.12530/117719
https://hdl.handle.net/20.500.12530/93878
https://incliva.fundanetsuite.com/publicaciones/ProdCientif/PublicacionFrw.aspx?id=17475
https://doaj.org/article/4b2f01f4e75d4aedaab63e873f6aa1b0
https://hdl.handle.net/11591/541924
https://doi.org/10.1002/cam4.5997

Discovery of Ruthenium(II) Metallocompound and Olaparib Synergy for Cancer Combination Therapy

Συγγραφείς: Nur Aininie Yusoh, Paul R. Tiley, Sarah James, Siti Norain Harun, Jim A. Thomas, Norazalina Saad, Ling‐Wei Hii, Suet Lin Chia, Martin R. Gill, Hasan Ahmad

Πηγή: J Med Chem

Θεματικοί όροι: Cytotoxicity, Cancer cell, Cancer research, Poly(ADP-ribose) Polymerase Inhibitors, DNA Nanotechnology and Bioanalytical Applications, Biochemistry, Ruthenium, Olaparib, In vitro, Cell Line, Tumor, Biochemistry, Genetics and Molecular Biology, Antineoplastic Combined Chemotherapy Protocols, Health Sciences, Genetics, Humans, Animals, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Molecular Biology, Biology, Zebrafish, Cancer, Ovarian Neoplasms, Life Sciences, DNA, Platinum-Based Cancer Chemotherapy, 3. Good health, Chemistry, Oncology, FOS: Biological sciences, Phthalazines, Medicine, Ruthenium Compounds, Female, Poly ADP ribose polymerase, Polymerase

Περιγραφή αρχείου: text

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37185020
https://cronfa.swan.ac.uk/Record/cronfa63458/Download/63458__27725__199ad70be9be42359e335260320b289f.pdf

Preclinical patient‐derived modeling of castration‐resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease

Συγγραφείς: Mohamed E. Elsesy, Su Jung Oh‐Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak‐Rothkamm, Malik Alawi, Christian Müller, Ulrich Schüller, Tobias Maurer, Gunhild von Amsberg, Cordula Petersen, Kai Rothkamm, Wael Mansour

Πηγή: Mol Oncol
Molecular Oncology, Vol 17, Iss 6, Pp 1129-1147 (2023)

Θεματικοί όροι: castration‐resistant prostate cancer, Male, Pulmonary and Respiratory Medicine, 0301 basic medicine, DNA Repair, homologous recombination, Cancer research, Gene, 03 medical and health sciences, Advancements in Prostate Cancer Research, Olaparib, Biochemistry, Genetics and Molecular Biology, Health Sciences, In vivo, Genetics, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Chemotherapy, Homologous recombination, Molecular Biology, Internal medicine, Biology, RC254-282, Research Articles, Cancer, 0303 health sciences, Prostate cancer, PARP inhibition, Prostate Cancer, ex vivo tumor cultures, LNCaP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Recombinational DNA Repair, Life Sciences, 3. Good health, Molecular Mechanisms of DNA Damage Response, Ex vivo, Prostatic Neoplasms, Castration-Resistant, PARP inhibitor, Oncology, patient‐derived organoids, FOS: Biological sciences, Medicine, RAD51, Poly ADP ribose polymerase, Cisplatin, Polymerase

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36694344
https://doaj.org/article/de640423cfee4a5e9ddaf1dec52ce8c8

Gamma radiation coupled ADP-ribosyl transferase activity of Pseudomonas aeruginosa PE24 moiety

Συγγραφείς: Radwa N. Morgan, Sarra E. Saleh, Hala A. Farrag, Khaled M. Aboshanab

Πηγή: Appl Microbiol Biotechnol

Θεματικοί όροι: 0301 basic medicine, DNA Repair, Molecular biology, Immunology, DNA Topoisomerases: Structure, Function, and Inhibition, Biochemistry, 03 medical and health sciences, Polyacrylamide gel electrophoresis, Stereochemistry, Biochemistry, Genetics and Molecular Biology, Health Sciences, Escherichia coli, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Biotechnologically Relevant Enzymes and Proteins, Molecular Biology, Biology, ADP Ribose Transferases, Immunology and Microbiology, 0303 health sciences, FOS: Clinical medicine, Moiety, Life Sciences, Gel electrophoresis, 3. Good health, Immunotoxin Therapy for Cancer Treatment, Chemistry, Oncology, Gamma Rays, Enzyme, Pseudomonas aeruginosa, Medicine

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36808279

Prevalence of Pathogenic Germline Mutations in 13 Hereditary Cancer-Related Genes in Breast Cancer Patients in Narathiwat Province, Thailand

Συγγραφείς: Panupong Sukpan, Kanyanatt Kanokwiroon, Hutcha Sriplung, Wison Laochareonsuk, Pongsakorn Choochuen, Nasuha Auseng, Kasemsun Wanawanakorn, Surasak Sangkhathat

Πηγή: Asian Pac J Cancer Prev

Θεματικοί όροι: Genotyping, Genetic testing, Germline, Genotype, Population, Breast Neoplasms, Penetrance, Gene, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, Biochemistry, Genetics and Molecular Biology, Health Sciences, Breast Cancer, Germline mutation, Prevalence, Genetics, KRAS, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Genetic Predisposition to Disease, Genetic Testing, Genetic Research on BRCA Mutations and Cancer Risk, Molecular Biology, Internal medicine, Biology, Germ-Line Mutation, CHEK2, Cancer, STK11, Life Sciences, Thailand, cancer susceptibility, BRCA1, Colorectal cancer, Cancer Risk, 3. Good health, Molecular Mechanisms of DNA Damage Response, Environmental health, Phenotype, Oncology, FOS: Biological sciences, PALB2, Mutation, Medicine, Female, Research Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36853301

Upregulation of p16INK4A in Peripheral White Blood Cells as a Novel Screening Marker for Colorectal Carcinoma

Συγγραφείς: Khin Thin, Phonthep Angsuwatcharakon, Steven W. Edwards, Apiwat Mutirangura, Charoenchai Puttipanyalears

Πηγή: Asian Pac J Cancer Prev

Θεματικοί όροι: Cancer Immunoediting, 0301 basic medicine, Immunology, Cancer Immunotherapy, Leukocyte Count, 03 medical and health sciences, Inflammation's Role in Cancer Development and Progression, Health Sciences, Leukocytes, Pathology, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Tumor marker, Internal medicine, Cyclin-Dependent Kinase Inhibitor p16, White blood cell, Cancer, 0303 health sciences, Blood Cells, FOS: Clinical medicine, Colorectal cancer, Immunohistochemistry, Up-Regulation, 3. Good health, Immune system, Oncology, Medicine, Colorectal Neoplasms, CD14, Biomarkers, Proliferation Marker, Research Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36444588

Low probability of disease cure in advanced ovarian carcinomas before the PARP inhibitor era

Συγγραφείς: Benoît You, Lilian van Wagensveld, Michel Tod, Gabe S. Sonke, Hugo M. Horlings, Roy F.P.M. Kruitwagen, Andreas du Bois, Frédèric Selle, Timothy Perren, Jacobus Pfisterer, Florence Joly, Adrian Cook, Marie Christine Kaminsky, K. Wollschlaeger, Alain Lortholary, Oliver Tomé, Alexandra Léary, Gilles Freyer, Maaike van der Aa, Olivier Colomban

Πηγή: Br J Cancer

Θεματικοί όροι: MODELED CA-125 KELIM, Antineoplastic Agents, Cancer research, Carcinoma, Ovarian Epithelial, Poly(ADP-ribose) Polymerase Inhibitors, Biochemistry, Gene, Article, 03 medical and health sciences, 0302 clinical medicine, CHEMOSENSITIVITY, Tumor Models, Health Sciences, Pathology, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Disease, Internal medicine, Biology, Neoplasm Staging, Probability, Retrospective Studies, Ovarian Neoplasms, Cytoreduction Surgical Procedures, Platinum-Sensitive Ovarian Cancer, CHEMOTHERAPY, CANCER, Neoadjuvant Therapy, Ovarian Cancer, 3. Good health, PARP inhibitor, Clinical Trials, Phase III as Topic, Genomic Studies and Treatment of Ovarian Carcinoma, Reproductive Medicine, Oncology, Chemotherapy, Adjuvant, Medicine, Cancer Therapy, Female, Poly ADP ribose polymerase, Polymerase

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35361918
https://cris.maastrichtuniversity.nl/en/publications/3f7a3473-b4f4-4169-b696-03130ba37220
https://doi.org/10.1038/s41416-022-01732-7
https://discovery-pp.ucl.ac.uk/id/eprint/10146578/

Exploratory biomarker analysis in the phase III L-MOCA study of olaparib maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer

Συγγραφείς: Huayi Li, Zhufeng Peng, Jun Zhu, Weidong Zhang, Yi Huang, Ruifang An, Hong Zheng, Pengpeng Qu, Li Wang, Qi Zhou, Danbo Wang, Ge Lou, Jing Wang, KUN WANG, Beihua Kong, Xing Xie, Rutie Yin, J.S.H. Low, Abdul Malik Rozita, Lim Chun Sen, Ying Meng, Kimberley L. Kiong, Jihong Liu, Zhiqing Liang, Weiguo Lü, Jianqing Zhu, Weiguo Hu, Wen-Hua Sun, Jingya Su, Qi‐Qi Wang, Rongyu Zang, Ding Ma, Qinglei Gao

Πηγή: BMC Med
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)

Θεματικοί όροι: 0301 basic medicine, Nanoelectronics and Transistors, PD-L1 expression, Biochemistry, Gene, Piperazines, B7-H1 Antigen, Engineering, Olaparib, 0302 clinical medicine, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Prospective Studies, Homologous Recombination, PARP inhibitors, Internal medicine, Cancer, Ovarian Neoplasms, BRCA1 Protein, Progression-free survival, Platinum-Sensitive Ovarian Cancer, Middle Aged, Immunohistochemistry, 3. Good health, Chemistry, Oncology, Genomic Studies and Treatment of Ovarian Carcinoma, Physical Sciences, Medicine, Female, Immunotherapy, Polymerase, Research Article, Adult, Immunology, Antineoplastic Agents, R Medicine, Maintenance Chemotherapy, 03 medical and health sciences, BRCA1/2, Ovarian cancer, Health Sciences, Biomarkers, Tumor, FOS: Electrical engineering, electronic engineering, information engineering, Humans, Chemotherapy, Electrical and Electronic Engineering, Aged, BRCA2 Protein, FOS: Clinical medicine, Biomarker, Platinum-sensitive relapsed ovarian cancer, Immune system, Reproductive Medicine, Phthalazines, Poly ADP ribose polymerase, Neoplasm Recurrence, Local, Homologous recombination deficiency

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38755585
https://doaj.org/article/f5e3af1247dd40f9aa8344da62322e0a

The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association

Συγγραφείς: Tao Zheng, Beilei Shen, Yu Bai, Entao Li, Xun Zhang, Yong Hu, Ting Gao, Qincai Dong, Lin Zhu, Rui Jin, Hui Shi, Hainan Liu, Yuwei Gao, Xuan Liu, Cheng Cao

Πηγή: J Virol

Θεματικοί όροι: 0301 basic medicine, Infectious disease (medical specialty), Viral Nonstructural Proteins, FOS: Health sciences, Virus Replication, Gene, Mice, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Disease, Cyclic AMP Response Element-Binding Protein, Internal medicine, Adenosine Triphosphatases, 0303 health sciences, Coronavirus RNA-Dependent RNA Polymerase, CREB, Life Sciences, 3. Good health, Infectious Diseases, Oncology, Medicine, CREB1, Female, RNA Helicases, Signal Transduction, Cell biology, Coronavirus Disease 2019 Research, Antiviral Agents, Helicase, Inhibitory Concentration 50, 03 medical and health sciences, Biochemistry, Genetics and Molecular Biology, Virology, Health Sciences, Genetics, Humans, Animals, Biology, Cyclic AMP-Dependent Protein Kinase Catalytic Subunits, Corona Virus, Host Microbial Interactions, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), DNA Helicases, COVID-19, Outbreak, Cyclic AMP-Dependent Protein Kinases, Coronavirus, Coronavirus disease 2019 (COVID-19), FOS: Biological sciences, Pathogenesis and Immunity, RNA, Gene Therapy Techniques and Applications, Transcription factor, 2019-20 coronavirus outbreak

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38445884

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

Συγγραφείς: Liberalis Debraj Boila, Subhadeep Ghosh, Subham K. Bandyopadhyay, Ligen Lin, Alex Murison, Andy G.X. Zeng, Wasim Shaikh, Satyaki Bhowmik, Siva Sai Naga Anurag Muddineni, Mayukh Biswas, Sayantani Sinha, Shankha Subhra Chatterjee, Nathan Mbong, Olga I. Gan, Anwesha Bose, Sanjoy Chakraborty, Andrea Arruda, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta

Πηγή: Leukemia. 37:751-764

Θεματικοί όροι: Acute Myeloid Leukemia, 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, Synthetic lethality, DNA Repair, Demethylase, Immunology, Karyotype, DNA repair, Cancer research, Poly(ADP-ribose) Polymerase Inhibitors, Chromosome, Gene, Role of Histone Deacetylases in Cellular Regulation, 03 medical and health sciences, AML, Biochemistry, Genetics and Molecular Biology, Health Sciences, Genetics, Humans, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Molecular Biology, Biology, Histone Demethylases, 0303 health sciences, Leukemia, FOS: Clinical medicine, Daunorubicin, Life Sciences, Hematology, DNA, Leukemia, Myeloid, Acute, Histone, Myeloid leukemia, Proto-Oncogene Proteins c-bcl-2, Oncology, FOS: Biological sciences, Medicine, DNA damage, NPM1, Epigenetics, Poly ADP ribose polymerase, Polymerase

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36720973

The risk and prognostic influence of caspase 9 promotor polymorphisms in Egyptian patients with acute myeloid leukemia

Συγγραφείς: Manal Mohamed Makhlouf, M. M. Ayoub, Dalia Farag Mourad

Πηγή: Journal of Hematopathology. 15:131-140

Θεματικοί όροι: Acute Myeloid Leukemia, Genotype, Immunology, Cancer research, Gene, 03 medical and health sciences, 0302 clinical medicine, AML, Biochemistry, Genetics and Molecular Biology, Health Sciences, Molecular Mechanisms of Apoptosis and Cell Death, Genetics, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Molecular Biology, Internal medicine, Biology, Single-nucleotide polymorphism, Leukemia, Stem cell, FOS: Clinical medicine, Life Sciences, Hematology, 3. Good health, Myeloid leukemia, Haematopoiesis, Oncology, FOS: Biological sciences, Medicine

The role of CTRP9 on Inhibition the High-glucose-induced Apoptosis of Myocardial Cells via Wnt/β-catenin Signal Pathway

Συγγραφείς: Qian Zhang, Liying Pei, Jiali Fu, Rui Zhao

Πηγή: Cellular and Molecular Biology. 68:59-66

Θεματικοί όροι: 0301 basic medicine, Cell biology, Apoptosis, Western blot, Signal transduction, Biochemistry, Gene, Wnt signaling pathway, 03 medical and health sciences, Endocrinology, Health Sciences, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Wnt Signaling Pathway, Internal medicine, Biology, beta Catenin, bcl-2-Associated X Protein, Cell Death, Caspase 3, TUNEL assay, Downregulation and upregulation, 3. Good health, Catenin, Chemistry, Glucose, Proto-Oncogene Proteins c-bcl-2, Oncology, Medicine

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35809327

Treatment Outcomes of Epithelial Ovarian Cancer A Longitudinal Study

Συγγραφείς: Perwasha Kerio, Khadijah Abid, Anusha Hassan, Aamera Shah, Ammara Manzoor

Πηγή: Asian Pacific Journal of Cancer Care, Vol 7, Iss 2, Pp 253-259 (2022)

Θεματικοί όροι: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Paleontology, Ovarian Cancer, Carboplatin, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Genomic Studies and Treatment of Ovarian Carcinoma, Reproductive Medicine, Oncology, ovarian cancer, surgery, systematic chemotherapy, treatment outcomes, relapse, Ovarian cancer, Health Sciences, Medicine, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Cancer Therapy, Chemotherapy, Surgery, Cisplatin, Internal medicine, Biology, RC254-282, Stage (stratigraphy), Cancer

Σύνδεσμος πρόσβασης: https://doaj.org/article/556d1ae0cc0941378db77cef7c25235d

PARP14 inhibits the inflammatory response of macrophages through the NF-κB pathway

Συγγραφείς: Xuefei Guo, Yang Zhao

Θεματικοί όροι: Molecular Mechanisms of Inflammasome Activation and Regulation, Cell biology, NFKB1, Macrophage, Immunology, Signal transduction, Biochemistry, Gene, NF-κB, In vitro, Biochemistry, Genetics and Molecular Biology, Health Sciences, Poly(ADP-ribose) Polymerase Inhibition in Cancer Therapy, Molecular Biology, Calcineurin-NFAT Signaling in Transcriptional Regulation, Biology, Inflammation, FOS: Clinical medicine, Life Sciences, Inflammatory response, 16. Peace & justice, PARP Inhibitors, 3. Good health, Chemistry, Oncology, Medicine, Transcription factor