Molecular determinants of lung function decline: a multi-level analysis of gene expression

Συγγραφείς: Zaid W. Elhusseini, Omar Rafique, Min Hyung Ryu, Peter Castaldi, Don D. Sin, Ingo Ruczinski, Craig P. Hersh

Πηγή: Respiratory Research, Vol 27, Iss 1, Pp 1-9 (2025)

Θεματικοί όροι: COPD, Pulmonary function tests, RNA-sequencing, Longitudinal analysis, Biomarkers, Diseases of the respiratory system, RC705-779

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1465-993X

Σύνδεσμος πρόσβασης: https://doaj.org/article/124830d106c940ca9f9b9f0399b98ddd

New approaches to uncover COPD pathobiology and develop therapies

Συγγραφείς: Yohannes Tesfaigzi, Ali Önder Yildirim, Francesca Polverino, Thomas M. Conlon, Venkataramana Sidhaye, Maor Sauler, S. Vamsee Raju, Renata Z. Jurkowska, Divay Chandra, Michael H. Cho, Edwin K. Silverman, Ramon C. Sun, Peter Castaldi, Purushothama Rao Tata, Kambez H. Benam, Linto Antony, Mareike Lehmann, Beata Kosmider, Karim Bahmed, Zerihun H. Negasi, Kamakshi Bankoti, Carter Swaby, Dave A. Lagowala, Yeşim Vural, Hasan Bayram, Rosa Faner, George Washko, Dinh Son Bui, Bartolome Celli, Roxana Maria Wasnick, Enid Neptune

Πηγή: JCI Insight, Vol 11, Iss 4 (2026)

Θεματικοί όροι: Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2379-3708

Σύνδεσμος πρόσβασης: https://doaj.org/article/cacc5d48ee8c4f57a90857bad9af5ee6

Frequency of cannabis use and symptoms of anxiety and depression: a cross-sectional analysis of the Colorado cannabis users health cohort

Συγγραφείς: Christine M. Steeger, Poojashree Tandukar, Karin F. Hoth, Mark Aloia, Fred Wamboldt, Peter Castaldi, Sunita Sharma, Nancy Lorenzon, Laura E. Crotty Alexander, Jost Klawitter, Cristina Sempio, Gregory L. Kinney, Meghan D. Althoff, Gina R. Kruse, Russell P. Bowler

Πηγή: Journal of Cannabis Research, Vol 7, Iss 1, Pp 1-11 (2025)

Θεματικοί όροι: Cannabis use, Anxiety, Depression, Urinary cannabinoids, Adults, Pharmacy and materia medica, RS1-441, Plant culture, SB1-1110

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2522-5782

Σύνδεσμος πρόσβασης: https://doaj.org/article/65de2d1da05c4d9aa1973edbd56bd145

A statistical physics approach to integrating multi-omics data for disease-module detection

Συγγραφείς: Xu-Wen Wang, Min Hyung Ryu, Michael H. Cho, Peter Castaldi, Craig P. Hersh, Edwin K. Silverman, Yang-Yu Liu

Πηγή: Cell Reports: Methods, Vol 5, Iss 10, Pp 101183- (2025)

Θεματικοί όροι: CP: Systems biology, CP: Genetics, Biotechnology, TP248.13-248.65, Biochemistry, QD415-436, Science

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266723752500219X; https://doaj.org/toc/2667-2375

Σύνδεσμος πρόσβασης: https://doaj.org/article/01105979eb8641bd8d2109493fb84c2d

Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores

Συγγραφείς: Yana Hrytsenko, Benjamin Shea, Michael Elgart, Nuzulul Kurniansyah, Genevieve Lyons, Alanna C. Morrison, April P. Carson, Bernhard Haring, Braxton D. Mitchell, Bruce M. Psaty, Byron C. Jaeger, C. Charles Gu, Charles Kooperberg, Daniel Levy, Donald Lloyd-Jones, Eunhee Choi, Jennifer A. Brody, Jennifer A. Smith, Jerome I. Rotter, Matthew Moll, Myriam Fornage, Noah Simon, Peter Castaldi, Ramon Casanova, Ren-Hua Chung, Robert Kaplan, Ruth J. F. Loos, Sharon L. R. Kardia, Stephen S. Rich, Susan Redline, Tanika Kelly, Timothy O’Connor, Wei Zhao, Wonji Kim, Xiuqing Guo, Yii-Der Ida Chen, The Trans-Omics in Precision Medicine Consortium, Tamar Sofer

Πηγή: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

Θεματικοί όροι: Medicine, Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2045-2322

Σύνδεσμος πρόσβασης: https://doaj.org/article/322241f378754ea881e603a18375361b

Expression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study

Συγγραφείς: Amena Keshawarz, Helena Bui, Roby Joehanes, Jiantao Ma, Chunyu Liu, Tianxiao Huan, Shih-Jen Hwang, Brandon Tejada, Meera Sooda, Paul Courchesne, Peter J. Munson, Cumhur Y. Demirkale, Chen Yao, Nancy L. Heard-Costa, Achilleas N. Pitsillides, Honghuang Lin, Ching-Ti Liu, Yuxuan Wang, Gina M. Peloso, Jessica Lundin, Jeffrey Haessler, Zhaohui Du, Michael Cho, Craig P. Hersh, Peter Castaldi, Laura M. Raffield, Jia Wen, Yun Li, Alexander P. Reiner, Mike Feolo, Nataliya Sharopova, Ramachandran S. Vasan, Dawn L. DeMeo, April P. Carson, Charles Kooperberg, Daniel Levy

Πηγή: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Θεματικοί όροι: Medicine, Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2045-2322

Σύνδεσμος πρόσβασης: https://doaj.org/article/c06dd3b583dc4254b2ae2dc78e88198e

Development and validation of a mortality risk prediction model for chronic obstructive pulmonary disease: a cross-sectional study using probabilistic graphical modellingResearch in context

Συγγραφείς: Tyler C. Lovelace, Min Hyung Ryu, Minxue Jia, Peter Castaldi, Frank C. Sciurba, Craig P. Hersh, Panayiotis V. Benos

Πηγή: EClinicalMedicine, Vol 75, Iss , Pp 102786- (2024)

Θεματικοί όροι: COPD mortality, Graphical models, Machine learning, Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024003651; https://doaj.org/toc/2589-5370

Σύνδεσμος πρόσβασης: https://doaj.org/article/4765a28384224a6dad0ead91b62ebc11

Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis

Συγγραφείς: Kristina L. Buschur, Craig Riley, Aabida Saferali, Peter Castaldi, Grace Zhang, Francois Aguet, Kristin G. Ardlie, Peter Durda, W. Craig Johnson, Silva Kasela, Yongmei Liu, Ani Manichaikul, Stephen S. Rich, Jerome I. Rotter, Josh Smith, Kent D. Taylor, Russell P. Tracy, Tuuli Lappalainen, R. Graham Barr, Frank Sciurba, Craig P. Hersh, Panayiotis V. Benos

Πηγή: Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)

Θεματικοί όροι: COPD, Graphical models, Gene expression, Disease subtypes, Diseases of the respiratory system, RC705-779

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1465-993X

Σύνδεσμος πρόσβασης: https://doaj.org/article/2432ac0f1e9a4ee08f8823576baf8705

Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthmaResearch in context

Συγγραφείς: Kathryn Recto, Priyadarshini Kachroo, Tianxiao Huan, David Van Den Berg, Gha Young Lee, Helena Bui, Dong Heon Lee, Jessica Gereige, Chen Yao, Shih-Jen Hwang, Roby Joehanes, Scott T. Weiss, George T. O’Connor, Daniel Levy, Dawn L. DeMeo, Namiko Abe, Gonçalo Abecasis, Francois Aguet, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Kristin Ardlie, Dan Arking, Donna K. Arnett, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, Najib Ayas, Adithya Balasubramanian, John Barnard, Kathleen Barnes, R. Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Rebecca Beer, Amber Beitelshees, Emelia Benjamin, Takis Benos, Marcos Bezerra, Larry Bielak, Joshua Bis, Thomas Blackwell, John Blangero, Nathan Blue, Eric Boerwinkle, Donald W. Bowden, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Jai Broome, Deborah Brown, Karen Bunting, Esteban Burchard, Carlos Bustamante, Erin Buth, Brian Cade, Jonathan Cardwell, Vincent Carey, Julie Carrier, April P. Carson, Cara Carty, Richard Casaburi, Juan P. Casas Romero, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Yii-Der Ida Chen, Michael Cho, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Adolfo Correa, Carolyn Crandall, James Crapo, L. Adrienne Cupples, Joanne Curran, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Sean David, Colleen Davis, Michelle Daya, Mariza de Andrade, Lisa de las Fuentes, Paul de Vries, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Huyen Dinh, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Ravi Duggirala, Jon Peter Durda, Susan K. Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Patrick Ellinor, Leslie Emery, Serpil Erzurum, Charles Farber, Jesse Farek, Tasha Fingerlin, Matthew Flickinger, Myriam Fornage, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Yan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Stephanie Gogarten, Da-Wei Gong, Harald Goring, Sharon Graw, Kathryn J. Gray, Daniel Grine, Colin Gross, C. Charles Gu, Yue Guan, Xiuqing Guo, Namrata Gupta, Jeff Haessler, Michael Hall, Yi Han, Patrick Hanly, Daniel Harris, Nicola L. Hawley, Jiang He, Ben Heavner, Susan Heckbert, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, John Hokanson, Elliott Hong, Karin Hoth, Chao (Agnes) Hsiung, Jianhong Hu, Yi-Jen Hung, Haley Huston, Chii Min Hwu, Marguerite Ryan Irvin, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Robert Kaplan, Sharon Kardia, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Ziad Khan, Wonji Kim, John Kimoff, Greg Kinney, Barbara Konkle, Charles Kooperberg, Holly Kramer, Christoph Lange, Ethan Lange, Leslie Lange, Cathy Laurie, Cecelia Laurie, Meryl LeBoff, Jiwon Lee, Sandra Lee, Wen-Jane Lee, Jonathon LeFaive, David Levine, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Xihong Lin, Simin Liu, Yongmei Liu, Yu Liu, Ruth J.F. Loos, Steven Lubitz, Kathryn Lunetta, James Luo, Ulysses Magalang, Michael Mahaney, Barry Make, Ani Manichaikul, Alisa Manning, JoAnn Manson, Lisa Martin, Melissa Marton, Susan Mathai, Rasika Mathias, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Stephen McGarvey, Daniel McGoldrick, Caitlin McHugh, Becky McNeil, Hao Mei, James Meigs, Vipin Menon, Luisa Mestroni, Ginger Metcalf, Deborah A. Meyers, Emmanuel Mignot, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L. Minster, Braxton D. Mitchell, Matt Moll, Zeineen Momin, May E. Montasser, Courtney Montgomery, Donna Muzny, Josyf C. Mychaleckyj, Girish Nadkarni, Rakhi Naik, Take Naseri, Pradeep Natarajan, Sergei Nekhai, Sarah C. Nelson, Bonnie Neltner, Caitlin Nessner, Deborah Nickerson, Osuji Nkechinyere, Kari North, Jeff O'Connell, Tim O'Connor, Heather Ochs-Balcom, Geoffrey Okwuonu, Allan Pack, David T. Paik, Nicholette Palmer, James Pankow, George Papanicolaou, Cora Parker, Gina Peloso, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S. Phillips, Jacob Pleiness, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Bruce Psaty, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Laura Raffield, Mahitha Rajendran, Vasan S. Ramachandran, D.C. Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Susan Redline, Robert Reed, Catherine Reeves, Elizabeth Regan, Alex Reiner, Muagututi‘a Sefuiva Reupena, Ken Rice, Stephen Rich, Rebecca Robillard, Nicolas Robine, Dan Roden, Carolina Roselli, Jerome Rotter, Ingo Ruczinski, Alexi Runnels, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Sejal Salvi, Steven Salzberg, Kevin Sandow, Vijay G. Sankaran, Jireh Santibanez, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Frédéric Sériès, Vivien Sheehan, Stephanie L. Sherman, Amol Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, M. Benjamin Shoemaker, Brian Silver, Edwin Silverman, Robert Skomro, Albert Vernon Smith, Jennifer Smith, Josh Smith, Nicholas Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Nona Sotoodehnia, Adrienne M. Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Daniel Taliun, Hua Tang, Margaret Taub, Kent Taylor, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A. Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Russell Tracy, Michael Tsai, Dhananjay Vaidya, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Fei Fei Wang, Heming Wang, Jiongming Wang, Karol Watson, Jennifer Watt, Daniel E. Weeks, Joshua Weinstock, Bruce Weir, Lu-Chen Weng, Jennifer Wessel, Cristen Willer, Kayleen Williams, L. Keoki Williams, Scott Williams, Carla Wilson, James Wilson, Lara Winterkorn, Quenna Wong, Baojun Wu, Joseph Wu, Huichun Xu, Lisa Yanek, Ivana Yang, Ketian Yu, Seyedeh Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Xiaofeng Zhu, Elad Ziv, Michael Zody, Sebastian Zoellner

Πηγή: EBioMedicine, Vol 95, Iss , Pp 104758- (2023)

Θεματικοί όροι: EWAS, DNA methylation, IgE, Asthma, RNA-Sequencing, Mendelian randomization, Medicine, Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423003237; https://doaj.org/toc/2352-3964

Σύνδεσμος πρόσβασης: https://doaj.org/article/27216a63c1a4464a8d8e43ae3d837982

Alternative poly-adenylation modulates α1-antitrypsin expression in chronic obstructive pulmonary disease.

Συγγραφείς: Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach

Πηγή: PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)

Θεματικοί όροι: Genetics, QH426-470

Περιγραφή αρχείου: electronic resource

Relation: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009912&type=printable; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Σύνδεσμος πρόσβασης: https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b

RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD

Συγγραφείς: Jarrett D. Morrow, Robert P. Chase, Margaret M. Parker, Kimberly Glass, Minseok Seo, Miguel Divo, Caroline A. Owen, Peter Castaldi, Dawn L. DeMeo, Edwin K. Silverman, Craig P. Hersh

Πηγή: Respiratory Research, Vol 20, Iss 1, Pp 1-12 (2019)

Θεματικοί όροι: COPD, Emphysema, Genomics, RNA-seq, Transcriptomics, Diseases of the respiratory system, RC705-779

Περιγραφή αρχείου: electronic resource

Relation: http://link.springer.com/article/10.1186/s12931-019-1032-z; https://doaj.org/toc/1465-993X

Σύνδεσμος πρόσβασης: https://doaj.org/article/26b8e043bbf449e69fd293feaea5a758

A Pilot Study on the Impact of Vaping on Adolescent Lung Function and Nasal Epithelial Gene Expression

Συγγραφείς: Sarah Commodore, Jonathan Hawkins, Cheyret Wood, Cuining Liu, Russell P. Bowler, Laura Crotty Alexander, Peter Castaldi, Fernando Holguin, Katerina Kechris, Sunita Sharma

Πηγή: American Journal of Respiratory Cell and Molecular Biology. 72:594-597

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40311078

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging

Συγγραφείς: Woei-Yuh Saw, Kangjin Kim, Yichen Huang, Jeong H Yun, Xiaolong Ma, Jason Bacon, Yash Pershad, Daniel Levy, George T O’Connor, Eric Boerwinkle, R Graham Barr, Stephen S Rich, Jerome I Rotter, April P Carson, Laura M Raffield, Sina A Gharib, Traci M Bartz, Bruce M Psaty, Tamar Sofer, Kari E North, Robert Kaplan, Elizabeth C Oelsner, Ani Manichaikul, Alexander G Bick, Paul Scheet, Alexander P Reiner, Gonçalo Abecasis, Francois Aguet, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Kristin Ardlie, Dan Arking, Donna K Arnett, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, Najib Ayas, John Barnard, Kathleen Barnes, Emily Barron-Casella, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Amber Beitelshees, Marcos Bezerra, Larry Bielak, Joshua Bis, John Blangero, Nathan Blue, Donald W Bowden, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Deborah Brown, Esteban Burchard, Carlos Bustamante, Brian Cade, Jonathan Cardwell, Vincent Carey, Cara Carty, Richard Casaburi, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Wei-Min Chen, Yii-Der Ida Chen, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Carolyn Crandall, James Crapo, L Adrienne Cupples, Joanne Curran, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Colleen Davis, Michelle Daya, Mariza de Andrade, Lisa de las Fuentes, Paul de Vries, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Ravi Duggirala, Jon Peter Durda, Susan K Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Patrick Ellinor, Serpil Erzurum, Charles Farber, Tasha Fingerlin, Myriam Fornage, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Mark Gladwin, David Glahn, Stephanie Gogarten, Harald Goring, Sharon Graw, Kathryn J Gray, C Charles Gu, Xiuqing Guo, Namrata Gupta, Jeff Haessler, Michael Hall, Patrick Hanly, Daniel Harris, Nicola L Hawley, Jiang He, Ben Heavner, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, John Hokanson, Karin Hoth, Chao (Agnes) Hsiung, Chii Min Hwu, Marguerite Ryan Irvin, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Sharon Kardia, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Wonji Kim, Greg Kinney, Barbara Konkle, Charles Kooperberg, Holly Kramer, Christoph Lange, Ethan Lange, Cathy Laurie, Meryl LeBoff, Wen-Jane Lee, Jonathon LeFaive, Dan Levy, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Xihong Lin, Simin Liu, Yongmei Liu, Yu Liu, Ruth J F Loos, Steven Lubitz, Kathryn Lunetta, James Luo, Ulysses Magalang, Michael Mahaney, Barry Make, Alisa Manning, JoAnn Manson, Lisa Martin, Melissa Marton, Susan Mathai, Rasika Mathias, Patrick McArdle, Merry-Lynn McDonald, Becky McNeil, Hao Mei, James Meigs, Luisa Mestroni, Ginger Metcalf, Deborah A Meyers, Emmanuel Mignot, Julie Mikulla, Yuan-I Min, Ryan L Minster, Braxton D Mitchell, Matt Moll, May Montasser, Courtney Montgomery, Donna Muzny, Josyf C Mychaleckyj, Girish Nadkarni, Rakhi Naik, Pradeep Natarajan, Sergei Nekhai, Kari North, Jeff O'Connell, Tim O'Connor, Heather Ochs-Balcom, Allan Pack, Nicholette Palmer, James Pankow, Gina Peloso, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S Phillips, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Bruce Psaty, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Laura Raffield, D C Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Susan Redline, Robert Reed, Catherine Reeves, Elizabeth Regan, Alex Reiner, Rebecca Robillard, Nicolas Robine, Dan Roden, Carolina Roselli, Jerome Rotter, Ingo Ruczinski, Alexi Runnels, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Steven Salzberg, Kevin Sandow, Vijay G Sankaran, Richa Saxena, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Vivien Sheehan, Stephanie L Sherman, Amol Shetty, Wayne Hui-Heng Sheu, M Benjamin Shoemaker, Brian Silver, Albert Vernon Smith, Jennifer Smith, Josh Smith, Nicholas Smith, Sylvia Smoller, Michael Snyder, Nona Sotoodehnia, Adrienne M Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Adam Szpiro, Hua Tang, Margaret Taub, Kent D Taylor, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Russell Tracy, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Scott Vrieze, Tarik Walker, Robert Wallace, Heming Wang, Jiongming Wang, Karol Watson, Daniel E Weeks, Joshua Weinstock, Lu-Chen Weng, Jennifer Wessel, L Keoki Williams, Scott Williams, Carla Wilson, Lara Winterkorn, Baojun Wu, Joseph Wu, Huichun Xu, Lisa Yanek, Ivana Yang, Ronit Yarden, Seyedeh Maryam Zekavat, Yingze Zhang, Wei Zhao, Xiaofeng Zhu, Elad Ziv, Michael Zody, Yasminka A Jakubek, Paul L Auer, Michael H Cho, Dawn L DeMeo

Πηγή: American Journal of Respiratory and Critical Care Medicine.

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

Συγγραφείς: Wei Sun, Katerina Kechris, Sean Jacobson, M Bradley Drummond, Gregory A Hawkins, Jenny Yang, Ting-Huei Chen, Pedro Miguel Quibrera, Wayne Anderson, R Graham Barr, Patricia V Basta, Eugene R Bleecker, Terri Beaty, Richard Casaburi, Peter Castaldi, Michael H Cho, Alejandro Comellas, James D Crapo, Gerard Criner, Dawn Demeo, Stephanie A Christenson, David J Couper, Jeffrey L Curtis, Claire M Doerschuk, Christine M Freeman, Natalia A Gouskova, MeiLan K Han, Nicola A Hanania, Nadia N Hansel, Craig P Hersh, Eric A Hoffman, Robert J Kaner, Richard E Kanner, Eric C Kleerup, Sharon Lutz, Fernando J Martinez, Deborah A Meyers, Stephen P Peters, Elizabeth A Regan, Stephen I Rennard, Mary Beth Scholand, Edwin K Silverman, Prescott G Woodruff, Wanda K O'Neal, Russell P Bowler, SPIROMICS Research Group, COPDGene Investigators

Πηγή: PLoS Genetics, Vol 12, Iss 8, p e1006011 (2016)

Θεματικοί όροι: Genetics, QH426-470

Περιγραφή αρχείου: electronic resource

Relation: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006011&type=printable; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Σύνδεσμος πρόσβασης: https://doaj.org/article/917df52f00af40fdb31c85ca727686c7

Genetic regulation of expression of leukotriene A4 hydrolase

Συγγραφείς: Tomasz Szul, Peter Castaldi, Michael H. Cho, J. Edwin Blalock, Amit Gaggar

Πηγή: ERJ Open Research, Vol 2, Iss 1 (2016)

Θεματικοί όροι: Medicine

Περιγραφή αρχείου: electronic resource

Relation: http://openres.ersjournals.com/content/2/1/00058-2015.full; https://doaj.org/toc/2312-0541

Σύνδεσμος πρόσβασης: https://doaj.org/article/d1d2ba4f69f94a87b5036c9941135045

cellSTAAR: incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of noncoding regions

Συγγραφείς: Eric Van Buren, Yi Zhang, Xihao Li, Margaret Sunitha Selvaraj, Zilin Li, Hufeng Zhou, Nicholette D. Palmer, Donna K. Arnett, John Blangero, Eric Boerwinkle, Brian E. Cade, Jenna C. Carlson, April P. Carson, Yii-Der Ida Chen, Joanne Curran, Ravindranath Duggirala, Myriam Fornage, Nora Franceschini, Misa Graff, Charles Gu, Xiuqing Guo, Jiang He, Nancy Heard-Cosa, Lifang Hou, Yi-Jen Hung, Rita R. Kalyani, Sharon L. R. Kardia, Eimear Kenny, Charles Kooperberg, Brian G. Kral, Leslie Lange, Dan Levy, Changwei Li, Simin Liu, Donald Lloyd-Jones, Ruth J. F. Loos, Ani W. Manichaikul, Lisa Warsinger Martin, Rasika Mathias, Ryan L. Minster, Braxton D. Mitchell, Josyf C. Mychaleckyj, Take Naseri, Kari North, Jeff O’Connell, James A. Perry, Patricia A. Peyser, Bruce M. Psaty, Laura M. Raffield, Ramachandran S. Vasan, Susan Redline, Alex P. Reiner, Stephen S. Rich, Jennifer A. Smith, Brian Spitzer, Hua Tang, Kent D. Taylor, Russell Tracy, Satupa’itea Viali, Lisa Yanek, Wei Zhao, Namiko Abe, Gonçalo Abecasis, Francois Aguet, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Kristin Ardlie, Dan Arking, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, Najib Ayas, Adithya Balasubramanian, John Barnard, Kathleen Barnes, R. Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Rebecca Beer, Amber Beitelshees, Emelia Benjamin, Takis Benos, Marcos Bezerra, Larry Bielak, Joshua Bis, Thomas Blackwell, Nathan Blue, Donald W. Bowden, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Jai Broome, Deborah Brown, Karen Bunting, Esteban Burchard, Carlos Bustamante, Erin Buth, Jonathan Cardwell, Vincent Carey, Julie Carrier, Cara Carty, Richard Casaburi, Juan P. Casas Romero, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Michael Cho, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Adolfo Correa, Carolyn Crandall, James Crapo, L. Adrienne Cupples, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Sean David, Colleen Davis, Michelle Daya, Michael DeBaun, Dawn DeMeo, Ranjan Deka, Scott Devine, Huyen Dinh, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Jon Peter Durda, Susan K. Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Patrick Ellinor, Leslie Emery, Serpil Erzurum, Charles Farber, Jesse Farek, Tasha Fingerlin, Matthew Flickinger, Chris Frazar, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Yan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Stephanie Gogarten, Da-Wei Gong, Harald Goring, Sharon Graw, Kathryn J. Gray, Daniel Grine, Colin Gross, Yue Guan, Namrata Gupta, Jeff Haessler, Michael Hall, Yi Han, Patrick Hanly, Daniel Harris, Nicola L. Hawley, Ben Heavner, Susan Heckbert, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, John Hokanson, Elliott Hong, Karin Hoth, Chao Agnes Hsiung, Jianhong Hu, Haley Huston, Chii Min Hwu, Marguerite Ryan Irvin, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Robert Kaplan, Shannon Kelly, Michael Kessler, Alyna Khan, Ziad Khan, Wonji Kim, John Kimoff, Greg Kinney, Barbara Konkle, Holly Kramer, Christoph Lange, Ethan Lange, Cathy Laurie, Cecelia Laurie, Meryl LeBoff, Jonathon LeFaive, Jiwon Lee, Sandra Lee, Wen-Jane Lee, David Levine, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Yongmei Liu, Yu Liu, Steven Lubitz, Kathryn Lunetta, James Luo, Ulysses Magalang, Michael Mahaney, Barry Make, Alisa Manning, JoAnn Manson, Melissa Marton, Susan Mathai, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Stephen McGarvey, Daniel McGoldrick, Caitlin McHugh, Becky McNeil, Hao Mei, James Meigs, Vipin Menon, Luisa Mestroni, Ginger Metcalf, Deborah A. Meyers, Emmanuel Mignot, Julie Mikulla, Nancy Min, Mollie Minear, Matt Moll, Zeineen Momin, May E. Montasser, Courtney Montgomery, Donna Muzny, Girish Nadkarni, Rakhi Naik, Sergei Nekhai, Sarah C. Nelson, Bonnie Neltner, Caitlin Nessner, Deborah Nickerson, Osuji Nkechinyere, Tim O’Connor, Heather Ochs-Balcom, Geoffrey Okwuonu, Allan Pack, David T. Paik, Nicholette Palmer, James Pankow, George Papanicolaou, Cora Parker, Juan Manuel Peralta, Marco Perez, Ulrike Peters, Lawrence S. Phillips, Jacob Pleiness, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Mahitha Rajendran, D. C. Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Robert Reed, Catherine Reeves, Elizabeth Regan, Muagututi’a Sefuiva Reupena, Ken Rice, Rebecca Robillard, Nicolas Robine, Dan Roden, Carolina Roselli, Ingo Ruczinski, Alexi Runnels, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Sejal Salvi, Steven Salzberg, Kevin Sandow, Vijay G. Sankaran, Jireh Santibanez, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Vivien Sheehan, Stephanie L. Sherman, Amol Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, M. Benjamin Shoemaker, Brian Silver, Edwin Silverman, Robert Skomro, Albert Vernon Smith, Josh Smith, Nicholas Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Nona Sotoodehnia, Adrienne M. Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Frédéric Sériès, Daniel Taliun, Margaret Taub, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A. Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Fei Fei Wang, Heming Wang, Jiongming Wang, Karol Watson, Jennifer Watt, Daniel E. Weeks, Joshua Weinstock, Bruce Weir, Scott T. Weiss, Lu-Chen Weng, Jennifer Wessel, Cristen Willer, Kayleen Williams, L. Keoki Williams, Scott Williams, Carla Wilson, James Wilson, Lara Winterkorn, Quenna Wong, Baojun Wu, Joseph Wu, Huichun Xu, Ivana Yang, Ketian Yu, Seyedeh Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Xiaofeng Zhu, Elad Ziv, Michael Zody, Sebastian Zoellner, Mariza de Andrade, Paul de Vries, Lisa de las Fuentes, Jerome I. Rotter, Gina M. Peloso, Pradeep Natarajan, Xihong Lin

Πηγή: Nature Methods. 23:338-349

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41476111

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Συγγραφείς: Seung Hoan Choi, Sean J. Jurgens, Ling Xiao, Matthew C. Hill, Christopher M. Haggerty, Garðar Sveinbjörnsson, Valerie N. Morrill, Nicholas A. Marston, Lu-Chen Weng, James P. Pirruccello, David O. Arnar, Daniel Fannar Gudbjartsson, Helene Mantineo, Aenne S. von Falkenhausen, Andrea Natale, Arnljot Tveit, Bastiaan Geelhoed, Carolina Roselli, David R. Van Wagoner, Dawood Darbar, Doreen Haase, Elsayed Z. Soliman, Giovanni E. Davogustto, Goo Jun, Hugh Calkins, Jeffrey L. Anderson, Jennifer A. Brody, Jennifer L. Halford, John Barnard, John E. Hokanson, Jonathan D. Smith, Joshua C. Bis, Kendra Young, Linda S. B. Johnson, Lorenz Risch, Lorne J. Gula, Lydia Coulter Kwee, Mark D. Chaffin, Michael Kühne, Michael Preuss, Namrata Gupta, Navid A. Nafissi, Nicholas L. Smith, Peter M. Nilsson, Pim van der Harst, Quinn S. Wells, Renae L. Judy, Renate B. Schnabel, Renee Johnson, Roelof A. J. Smit, Stacey Gabriel, Stacey Knight, Tetsushi Furukawa, Thomas W. Blackwell, Victor Nauffal, Xin Wang, Yuan-I Min, Zachary T. Yoneda, Zachary W. M. Laksman, Connie R. Bezzina, Alvaro Alonso, Bruce M. Psaty, Christine M. Albert, Dan E. Arking, Dan M. Roden, Daniel I. Chasman, Daniel J. Rader, David Conen, David D. McManus, Diane Fatkin, Emelia J. Benjamin, Eric Boerwinkle, Gregory M. Marcus, Ingrid E. Christophersen, J. Gustav Smith, Jason D. Roberts, Laura M. Raffield, M. Benjamin Shoemaker, Michael H. Cho, Michael J. Cutler, Michiel Rienstra, Mina K. Chung, Morten S. Olesen, Moritz F. Sinner, Nona Sotoodehnia, Paulus Kirchhof, Ruth J. F. Loos, Saman Nazarian, Sanghamitra Mohanty, Scott M. Damrauer, Stefan Kaab, Susan R. Heckbert, Susan Redline, Svati H. Shah, Toshihiro Tanaka, Yusuke Ebana, Goncalo Abecasis, Xiaodong Bai, Suganthi Balasubramanian, Aris Baras, Christina Beechert, Boris Boutkov, Michael Cantor, Giovanni Coppola, Tanima De, Andrew Deubler, Aris Economides, Gisu Eom, Manuel A. R. Ferreira, Caitlin Forsythe, Erin D. Fuller, Zhenhua Gu, Lukas Habegger, Alicia Hawes, Marcus B. Jones, Katia Karalis, Shareef Khalid, Olga Krasheninina, Rouel Lanche, Michael Lattari, Dadong Li, Alexander Lopez, Luca A. Lotta, Kia Manoochehri, Adam J. Mansfield, Evan K. Maxwell, Jason Mighty, Lyndon J. Mitnaul, Mona Nafde, Jonas Nielsen, Sean O’Keeffe, Max Orelus, John D. Overton, Maria Sotiropoulos Padilla, Razvan Panea, Tommy Polanco, Manasi Pradhan, Ayesha Rasool, Jeffrey G. Reid, William Salerno, Thomas D. Schleicher, Alan Shuldiner, Katherine Siminovitch, Jeffrey C. Staples, Ricardo H. Ulloa, Niek Verweij, Louis Widom, Sarah E. Wolf, Namiko Abe, Gonçalo Abecasis, Francois Aguet, Laura Almasy, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Kristin Ardlie, Donna K. Arnett, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, Najib Ayas, Adithya Balasubramanian, Kathleen Barnes, R. Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Rebecca Beer, Amber Beitelshees, Takis Benos, Marcos Bezerra, Larry Bielak, John Blangero, Donald W. Bowden, Russell Bowler, Ulrich Broeckel, Jai Broome, Deborah Brown, Karen Bunting, Esteban Burchard, Carlos Bustamante, Erin Buth, Brian Cade, Jonathan Cardwell, Vincent Carey, Julie Carrier, Cara Carty, Richard Casaburi, Juan P. Casas Romero, James Casella, Peter Castaldi, Christy Chang, Yi-Cheng Chang, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Yii-Der Ida Chen, Lee-Ming Chuang, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Adolfo Correa, Carolyn Crandall, James Crapo, L. Adrienne Cupples, Joanne Curran, Jeffrey Curtis, Brian Custer, Coleen Damcott, Sean David, Colleen Davis, Michelle Daya, Mariza de Andrade, Lisa de las Fuentes, Paul de Vries, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Huyen Dinh, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Ravi Duggirala, Jon Peter Durda, Susan K. Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Leslie Emery, Serpil Erzurum, Charles Farber, Jesse Farek, Tasha Fingerlin, Matthew Flickinger, Myriam Fornage, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Weiniu Gan, Shanshan Gao, Yan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Stephanie Gogarten, Da-Wei Gong, Harald Goring, Sharon Graw, Kathryn J. Gray, Daniel Grine, Colin Gross, C. Charles Gu, Yue Guan, Xiuqing Guo, David M. Haas, Jeff Haessler, Michael Hall, Yi Han, Patrick Hanly, Daniel Harris, Nicola L. Hawley, Jiang He, null Ben Heavner, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, Elliott Hong, Karin Hoth, Chao Agnes Hsiung, Jianhong Hu, Yi-Jen Hung, Haley Huston, Chii Min Hwu, Marguerite Ryan Irvin, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Robert Kaplan, Sharon Kardia, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Ziad Khan, Wonji Kim, John Kimoff, Greg Kinney, Barbara Konkle, Charles Kooperberg, Holly Kramer, Christoph Lange, Ethan Lange, Leslie Lange, Cathy Laurie, Cecelia Laurie, Meryl LeBoff, Jiwon Lee, Sandra Lee, Wen-Jane Lee, Jonathon LeFaive, David Levine, null Dan Levy, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Xihong Lin, Simin Liu, Yongmei Liu, Yu Liu, James Luo, Ulysses Magalang, Michael Mahaney, Barry Make, Ani Manichaikul, Alisa Manning, JoAnn Manson, Lisa Martin, Melissa Marton, Susan Mathai, Rasika Mathias, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Stephen McGarvey, Daniel McGoldrick, Caitlin McHugh, Becky McNeil, Hao Mei, James Meigs, Vipin Menon, Luisa Mestroni, Ginger Metcalf, Deborah A. Meyers, Emmanuel Mignot, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L. Minster, Braxton D. Mitchell, Matt Moll, Zeineen Momin, May E. Montasser, Courtney Montgomery, Donna Muzny, Josyf C. Mychaleckyj, Girish Nadkarni, Rakhi Naik, Take Naseri, Pradeep Natarajan, Sergei Nekhai, Sarah C. Nelson, Bonnie Neltner, Caitlin Nessner, Deborah Nickerson, Osuji Nkechinyere, Kari North, Jeff O’Connell, Tim O’Connor, Heather Ochs-Balcom, Geoffrey Okwuonu, Allan Pack, David T. Paik, Nicholette Palmer, James Pankow, George Papanicolaou, Cora Parker, Gina Peloso, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S. Phillips, Jacob Pleiness, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Mahitha Rajendran, Vasan S. Ramachandran, D. C. Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Robert Reed, Catherine Reeves, Elizabeth Regan, Alex Reiner, Muagututi’a Sefuiva Reupena, Ken Rice, Stephen Rich, Rebecca Robillard, Nicolas Robine, Jerome Rotter, Ingo Ruczinski, Alexi Runnels, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Sejal Salvi, Steven Salzberg, Kevin Sandow, Vijay G. Sankaran, Jireh Santibanez, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Frédéric Sériès, Vivien Sheehan, Stephanie L. Sherman, Amol Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, Brian Silver, Edwin Silverman, Robert Skomro, Albert Vernon Smith, Jennifer Smith, Josh Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Adrienne M. Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Daniel Taliun, Hua Tang, Margaret Taub, Kent D. Taylor, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A. Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Russell Tracy, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Fei Fei Wang, Heming Wang, Jiongming Wang, Karol Watson, Jennifer Watt, Daniel E. Weeks, Joshua Weinstock, Bruce Weir, Scott T. Weiss, Jennifer Wessel, Cristen Willer, Kayleen Williams, L. Keoki Williams, Carla Wilson, James Wilson, Lara Winterkorn, Quenna Wong, Joseph Wu, Huichun Xu, Lisa Yanek, Ivana Yang, Ketian Yu, Seyedeh Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Xiaofeng Zhu, Michael Zody, Sebastian Zoellner, Hilma Holm, Kari Stefansson, Christian T. Ruff, Marc S. Sabatine, Kathryn L. Lunetta, Steven A. Lubitz, Patrick T. Ellinor

Πηγή: Nature Genetics

Θεματικοί όροι: Case-Control Studies, Atrial Fibrillation, Exome Sequencing, Humans, Genetic Variation, Genetic Predisposition to Disease, Myocytes, Cardiac, Genome-Wide Association Study

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40050430
https://pure.amsterdamumc.nl/en/publications/c77f517d-bc08-49e3-87cc-a441282d17e6
https://doi.org/10.1038/s41588-025-02074-9
https://hdl.handle.net/2108/417468
https://doi.org/10.1038/s41588-025-02074-9

A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

Συγγραφείς: Xihao Li, Han Chen, Margaret Sunitha Selvaraj, Eric Van Buren, Hufeng Zhou, Yuxuan Wang, Ryan Sun, Zachary R. McCaw, Zhi Yu, Min-Zhi Jiang, Daniel DiCorpo, Sheila M. Gaynor, Rounak Dey, Donna K. Arnett, Emelia J. Benjamin, Joshua C. Bis, John Blangero, Eric Boerwinkle, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, April P. Carson, Jenna C. Carlson, Nathalie Chami, Yii-Der Ida Chen, Joanne E. Curran, Paul S. de Vries, Myriam Fornage, Nora Franceschini, Barry I. Freedman, Charles Gu, Nancy L. Heard-Costa, Jiang He, Lifang Hou, Yi-Jen Hung, Marguerite R. Irvin, Robert C. Kaplan, Sharon L. R. Kardia, Tanika N. Kelly, Iain Konigsberg, Charles Kooperberg, Brian G. Kral, Changwei Li, Yun Li, Honghuang Lin, Ching-Ti Liu, Ruth J. F. Loos, Michael C. Mahaney, Lisa W. Martin, Rasika A. Mathias, Braxton D. Mitchell, May E. Montasser, Alanna C. Morrison, Take Naseri, Kari E. North, Nicholette D. Palmer, Patricia A. Peyser, Bruce M. Psaty, Susan Redline, Alexander P. Reiner, Stephen S. Rich, Colleen M. Sitlani, Jennifer A. Smith, Kent D. Taylor, Hemant K. Tiwari, Ramachandran S. Vasan, Satupa’itea Viali, Zhe Wang, Jennifer Wessel, Lisa R. Yanek, Bing Yu, Namiko Abe, Gonçalo Abecasis, Francois Aguet, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Kristin Ardlie, null Dan Arking, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Dimitrios Avramopoulos, Najib Ayas, Adithya Balasubramanian, John Barnard, Kathleen Barnes, R. Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Rebecca Beer, Amber Beitelshees, Takis Benos, Marcos Bezerra, Larry Bielak, Thomas Blackwell, Nathan Blue, Russell Bowler, Ulrich Broeckel, Jai Broome, Deborah Brown, Karen Bunting, Esteban Burchard, Carlos Bustamante, Erin Buth, Jonathan Cardwell, Vincent Carey, Julie Carrier, Cara Carty, Richard Casaburi, Juan P. Casas Romero, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Michael Cho, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Adolfo Correa, Carolyn Crandall, James Crapo, L. Adrienne Cupples, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Sean David, Colleen Davis, Michelle Daya, Michael DeBaun, Dawn DeMeo, Ranjan Deka, Scott Devine, Huyen Dinh, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Ravi Duggirala, Jon Peter Durda, Susan K. Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Patrick T. Ellinor, Leslie Emery, Serpil Erzurum, Charles Farber, Jesse Farek, Tasha Fingerlin, Matthew Flickinger, Chris Frazar, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Yan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Stephanie Gogarten, Da-Wei Gong, Harald Goring, Sharon Graw, Kathryn J. Gray, Daniel Grine, Colin Gross, Yue Guan, Xiuqing Guo, Namrata Gupta, Jeff Haessler, Michael Hall, Yi Han, Patrick Hanly, Daniel Harris, Nicola L. Hawley, null Ben Heavner, Susan Heckbert, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, John Hokanson, Elliott Hong, Karin Hoth, Chao Agnes Hsiung, Jianhong Hu, Haley Huston, Chii Min Hwu, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Ziad Khan, Wonji Kim, John Kimoff, Greg Kinney, Barbara Konkle, Holly Kramer, Christoph Lange, Ethan Lange, Leslie Lange, Cathy Laurie, Cecelia Laurie, Meryl LeBoff, Jonathon LeFaive, Jiwon Lee, Sandra Lee, Wen-Jane Lee, David Levine, Daniel Levy, Joshua Lewis, Xiaohui Li, Henry Lin, Simin Liu, Yongmei Liu, Yu Liu, Steven A. Lubitz, Kathryn L. Lunetta, James Luo, Ulysses Magalang, Barry Make, Ani Manichaikul, JoAnn Manson, Melissa Marton, Susan Mathai, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Stephen McGarvey, Daniel McGoldrick, Caitlin McHugh, Becky McNeil, Hao Mei, Vipin Menon, Luisa Mestroni, Ginger Metcalf, Deborah A. Meyers, Emmanuel Mignot, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L. Minster, Matt Moll, Zeineen Momin, Courtney Montgomery, Donna Muzny, Josyf C. Mychaleckyj, Girish Nadkarni, Rakhi Naik, Sergei Nekhai, Sarah C. Nelson, Bonnie Neltner, Caitlin Nessner, Deborah Nickerson, Osuji Nkechinyere, Jeff O’Connell, Tim O’Connor, Heather Ochs-Balcom, Geoffrey Okwuonu, Allan Pack, David T. Paik, James Pankow, George Papanicolaou, Cora Parker, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Lawrence S. Phillips, Jacob Pleiness, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Mahitha Rajendran, D. C. Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Robert Reed, Catherine Reeves, Elizabeth Regan, Muagututi’a Sefuiva Reupena, Rebecca Robillard, Nicolas Robine, null Dan Roden, Carolina Roselli, Ingo Ruczinski, Alexi Runnels, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Sejal Salvi, Steven Salzberg, Kevin Sandow, Vijay G. Sankaran, Jireh Santibanez, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Vivien Sheehan, Stephanie L. Sherman, Amol Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, M. Benjamin Shoemaker, Brian Silver, Edwin Silverman, Robert Skomro, Albert Vernon Smith, Josh Smith, Nicholas Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Nona Sotoodehnia, Adrienne M. Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Frédéric Sériès, Daniel Taliun, Hua Tang, Margaret Taub, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A. Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Catherine Tong, Russell Tracy, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Fei Fei Wang, Heming Wang, Jiongming Wang, Karol Watson, Jennifer Watt, Daniel E. Weeks, Joshua Weinstock, Bruce Weir, Scott T. Weiss, Lu-Chen Weng, Cristen Willer, Kayleen Williams, L. Keoki Williams, Scott Williams, Carla Wilson, James Wilson, Lara Winterkorn, Quenna Wong, Baojun Wu, Joseph Wu, Huichun Xu, Ivana Yang, Ketian Yu, Seyedeh Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Xiaofeng Zhu, Elad Ziv, Michael Zody, Sebastian Zoellner, Mariza de Andrade, Lisa de las Fuentes, Josée Dupuis, James B. Meigs, Paul L. Auer, Laura M. Raffield, Alisa K. Manning, Kenneth M. Rice, Jerome I. Rotter, Gina M. Peloso, Pradeep Natarajan, Zilin Li, Zhonghua Liu, Xihong Lin

Πηγή: Li, X, Chen, H, Selvaraj, M S, Van Buren, E, Zhou, H, Wang, Y, Sun, R, McCaw, Z R, Yu, Z, Jiang, M-Z, DiCorpo, D, Gaynor, S M, Dey, R, Arnett, D K, Benjamin, E J, Bis, J C, Blangero, J, Boerwinkle, E, Bowden, D W, Brody, J A, Cade, B E, Carson, A P, Carlson, J C, Chami, N, Chen, Y-D I, Curran, J E, de Vries, P S, Fornage, M, Franceschini, N, Freedman, B I, Gu, C, Heard-Costa, N L, He, J, Hou, L, Hung, Y-J, Irvin, M R, Kaplan, R C, Kardia, S L R, Kelly, T N, Konigsberg, I, Kooperberg, C, Kral, B G, Li, C, Li, Y, Lin, H, Loos, R J F, Chen, W-M, Liu, Y & NHLBI Trans Omics Precision Med TOPMed Consortium 2025, ' A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies ', Nature Computational Science, vol. 5, no. 5, pp. 125–143 . https://doi.org/10.1038/s43588-024-00764-8

Θεματικοί όροι: Association, Pleiotropy, Phenotype, Whole Genome Sequencing, Genome, Human, Humans, Genetic Variation, Diseases, Heart, Population-structure, Prediction, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39920506

Sex-Biased Regulation of Extracellular Matrix Genes in Chronic Obstructive Pulmonary Disease

Συγγραφείς: Camila M. Lopes-Ramos, Katherine H. Shutta, Min Hyung Ryu, Yichen Huang, Enakshi Saha, John Ziniti, Robert Chase, Brian D. Hobbs, Jeong H. Yun, Peter Castaldi, Craig P. Hersh, Kimberly Glass, Edwin K. Silverman, John Quackenbush, Dawn L. DeMeo

Πηγή: Am J Respir Cell Mol Biol

Θεματικοί όροι: Male, Sex Characteristics, Smoking, DNA Methylation, Middle Aged, Extracellular Matrix, Pulmonary Disease, Chronic Obstructive, Sex Factors, Gene Expression Regulation, Humans, Female, Gene Regulatory Networks, Lung, Original Research, Aged

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39102858
https://pmc.ncbi.nlm.nih.gov/articles/PMC11707671/
https://doi.org/10.1165/rcmb.2024-0226OC
https://pubmed.ncbi.nlm.nih.gov/39102858/

Call to Action: How Can We Promote the Development of New Pharmacologic Treatments in Chronic Obstructive Pulmonary Disease?

Συγγραφείς: Daniel C. Belz, Nirupama Putcha, Patricia Alupo, Trishul Siddharthan, Aaron Baugh, Nick Hopkinson, Peter Castaldi, Alberto Papi, David Mannino, Marc Miravitlles, MeiLan Han, Leonardo M. Fabbri, Maria Montes de Oca, Jerry A. Krishnan, Dave Singh, Fernando J. Martinez, Nadia N. Hansel, Peter Calverley

Πηγή: American Journal of Respiratory and Critical Care Medicine. 210:1300-1307

Θεματικοί όροι: Chronic Obstructive Pulmonary Disease (COPD), COPD exacerbations, biomarker, endpoint, pharmacotherapy, precision medicine, drug development

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39405496