Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers

Authors: Peter Müller, Andreas Draguhn, Alexei V. Egorov

Source: Pflugers Arch

Subject Terms: Neurons, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Humans, Animals, Review, Sodium Channels/metabolism [MeSH], Persistent sodium current, Humans [MeSH], Neurons/metabolism [MeSH], Sodium channel blocker, Slow inactivation, Animals [MeSH], Sodium Channel Blockers/pharmacology [MeSH], Neuron, Neurons/drug effects [MeSH], Sodium Channels/drug effects [MeSH], Neurons/physiology [MeSH], Epilepsy, Sodium Channels, Sodium Channel Blockers

Access URL: https://pubmed.ncbi.nlm.nih.gov/38967655
https://repository.publisso.de/resource/frl:6505822

SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons

Authors: Kotler, Oron, Khrapunsky, Yana, Shvartsman, Arik, Dai, Hui, Plant, Leigh D, Goldstein, Steven AN, Fleidervish, Ilya

Subject Terms: Biomedical and Clinical Sciences, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Mice, Animals, Action Potentials, Sumoylation, Pyramidal Cells, Neurons, Axon Initial Segment, SUMO, pyramidal neuron, axon initial segment, persistent sodium current, action potential, backpropagation, Mouse, mouse, neuroscience, Biochemistry and Cell Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

File Description: application/pdf

Access URL: https://escholarship.org/uc/item/6vr5s3qs
https://escholarship.org/content/qt6vr5s3qs/qt6vr5s3qs.pdf

Temporal Summation of Subthreshold Stimuli in Human Motor Axons: Implications for IONM.

Authors: Kelvin Jones, Ara Naidoo

Subject Terms: Neurology and neuromuscular diseases, Peripheral nervous system, intraoperative neuromonitoring (IONM), compound muscle action potential (CMAP), superexcitability, persistent sodium current

Relation: https://figshare.com/articles/journal_contribution/Temporal_Summation_of_Subthreshold_Stimuli_in_Human_Motor_Axons_Implications_for_IONM_/29897132

Availability: https://doi.org/10.6084/m9.figshare.29897132.v1
https://figshare.com/articles/journal_contribution/Temporal_Summation_of_Subthreshold_Stimuli_in_Human_Motor_Axons_Implications_for_IONM_/29897132

Spike-spindle coupling during sleep and its mechanism explanation in childhood focal epilepsy

Authors: Pan, Min, Li, Qiang, Song, Jiangling, Li, Duo, Zhang, Rui^{Aff1, IDs11571023100522_cor5}

Source: Cognitive Neurodynamics. :1-16

Cerebellar Nuclei and Cerebellar Learning

Authors: Jaeger, Dieter^Aff6, Gruol, Donna L., Section editor^Aff7

Contributors: Manto, Mario U., editor^Aff1, Gruol, Donna L., editor^Aff2, Schmahmann, Jeremy D., editor^Aff3, Koibuchi, Noriyuki, editor^Aff4, Sillitoe, Roy V., editor^Aff5

Source: Handbook of the Cerebellum and Cerebellar Disorders. :1251-1274

The effect of lamotrigine and other antiepileptic drugs on respiratory rhythm generation in the pre‐Bötzinger complex

Authors: Janine Brandes, Nikolas Layer, Henner Koch, Philipp Justus Lührs, Thomas V. Wuttke

Contributors: DSpace at Cambridge pro (8.1)

Source: Epilepsia : the journal of the International League Against Epilepsy 62(11), 2790-2803 (2021). doi:10.1111/epi.17066

Subject Terms: SUDEP, Sodium, Lamotrigine, pacemaker, 3. Good health, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, pre-Bötzinger complex, Anticonvulsants, lamotrigine, persistent sodium current, Sudden Unexpected Death in Epilepsy, Hypoxia, Sodium Channel Blockers

File Description: text/xml; application/pdf

Access URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/epi.17066
https://pubmed.ncbi.nlm.nih.gov/34553376
https://onlinelibrary.wiley.com/doi/10.1111/epi.17066
https://www.repository.cam.ac.uk/handle/1810/328411
https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.17066
https://pubmed.ncbi.nlm.nih.gov/34553376/
https://www.repository.cam.ac.uk/handle/1810/328411
https://doi.org/10.1111/epi.17066
https://doi.org/10.17863/cam.75860
https://publications.rwth-aachen.de/record/834182

Propranolol modulation of tetrodotoxin-resistant Na+ channels in dural afferent neurons

Authors: Nakamura, Michiko ^{a, b}, Jang, Il-Sung ^{a, b, ∗}

Source: In European Journal of Pharmacology 5 November 2021 910

Post-stroke epileptogenesis is associated with altered intrinsic properties of hippocampal pyramidal neurons leading to increased theta resonance

Authors: Vera, Jorge ^{a, b, 1}, Lippmann, Kristina ^{a, c, ⁎, 1}

Source: In Neurobiology of Disease August 2021 156

Role of Late Sodium Current During Repolarization and Its Pathophysiology

Authors: Chahine, Mohamed^{Aff2, Aff3}

Contributors: El-Sherif, Nabil, editor^Aff1

Source: Cardiac Repolarization : Basic Science and Clinical Management. :109-117

Dynamics of ramping bursts in a respiratory neuron model

Authors: Abdulla, Muhammad U., Phillips, Ryan S.^{Aff2, Aff3}, Rubin, Jonathan E.^{Aff2, Aff3, IDs1082702100800w_cor3}

Source: Journal of Computational Neuroscience. :1-20

SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons

Authors: Oron Kotler, Yana Khrapunsky, Arik Shvartsman, Hui Dai, Leigh D Plant, Steven AN Goldstein, Ilya Fleidervish

Source: eLife
eLife, Vol 12 (2023)

Subject Terms: 0301 basic medicine, Biomedical and clinical sciences, Mouse, QH301-705.5, 1.1 Normal biological development and functioning, Science, Action Potentials, axon initial segment, neuroscience, Mice, 03 medical and health sciences, action potential, Underpinning research, pyramidal neuron, Animals, persistent sodium current, Biology (General), mouse, Axon Initial Segment, Neurons, 0303 health sciences, Biomedical and Clinical Sciences, Pyramidal Cells, Neurosciences, Health sciences, Sumoylation, Biological sciences, SUMO, Medicine, Biochemistry and Cell Biology, backpropagation, Neuroscience

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/36794908
https://doaj.org/article/77f8c9ae611943e0a75a929dc508cb04
https://escholarship.org/uc/item/6vr5s3qs

Endogenous Polyamines Regulate Cortical Neuronal Excitability by Blocking Voltage-Gated Na⁺ Channels

Authors: Fleidervish, Ilya A., Libman, Lior, Katz, Efrat, Gutnick, Michael J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2008 Dec 01. 105(48), 18994-18999.

Access URL: https://www.jstor.org/stable/25465580

Persistent Sodium Current Drives Excitability of Immature Renshaw Cells in Early Embryonic Spinal Networks

Authors: Pascal Branchereau, Monara Kaelle Servulo Cruz Angelim, Antonny Czarnecki, Pascal Legendre, François-Xavier Lejeune, Barbara Le Bras, Christine Mouffle, Jean-Marie Mangin, Juliette Boeri, Hervé Le Corronc

Contributors: Sorbonne Université, Gestionnaire HAL 3

Source: The Journal of Neuroscience. 38:7667-7682

Subject Terms: Male, Renshaw Cells, 0301 basic medicine, Patch-Clamp Techniques, Action Potentials, Mice, Transgenic, Sodium Channels, Mice, 03 medical and health sciences, excitability, Paracrine Communication, Animals, persistent sodium current, Gene Knock-In Techniques, GABAergic Neurons, development, Motor Neurons, mouse embryo, 0303 health sciences, Riluzole, Sodium, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BDD.EO] Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, spontaneous network activity, 6. Clean water, Mice, Inbred C57BL, Spinal Cord, Synapses, Female, Nerve Net, Renshaw cell, Excitatory Amino Acid Antagonists

File Description: application/pdf

Access URL: https://www.jneurosci.org/content/jneuro/38/35/7667.full.pdf
https://pubmed.ncbi.nlm.nih.gov/30012693
https://europepmc.org/article/PMC/PMC6705967
http://www.jneurosci.org/content/38/35/7667
https://www.jneurosci.org/content/38/35/7667
https://www.ncbi.nlm.nih.gov/pubmed/30012693
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705967
https://www.jneurosci.org/content/jneuro/38/35/7667.full.pdf
https://hal.sorbonne-universite.fr/hal-03220695v2/document
https://doi.org/10.1523/jneurosci.3203-17.2018
https://hal.sorbonne-universite.fr/hal-03220695v2

Modulation of tetrodotoxin-resistant Na+ channels by amitriptyline in dural afferent neurons

Authors: Kang, In-Sik ^a, Cho, Jin-Hwa ^a, Lee, Maan-Gee ^{b, c}, Jang, Il-Sung ^{a, c, ⁎}

Source: In European Journal of Pharmacology 5 November 2018 838:69-77

Persistent Sodium Current Mediates the Steep Voltage Dependence of Spatial Coding in Hippocampal Pyramidal Neurons

Authors: Hsu, Ching-Lung ¹, Zhao, Xinyu ¹, Milstein, Aaron D. ², Spruston, Nelson ^{1, 3, ∗}

Source: In Neuron 11 July 2018 99(1):147-162

Environmental Enrichment and Social Isolation Mediate Neuroplasticity of Medium Spiny Neurons through the GSK3 Pathway

Authors: Scala, Federico ^{1, 8, 12}, Nenov, Miroslav N. ^{1, 12}, Crofton, Elizabeth J. ^{1, 3}, Singh, Aditya K. ¹, Folorunso, Oluwarotimi ¹, Zhang, Yafang ^{1, 4}, Chesson, Brent C. ^{1, 4}, Wildburger, Norelle C. ¹, James, Thomas F. ^{1, 3}, Alshammari, Musaad A. ^{1, 4, 11}, Alshammari, Tahani K. ^{1, 4, 11}, Elfrink, Hannah ^{1, 5}, Grassi, Claudio ^{9, 10}, Kasper, James M. ^{1, 6}, Smith, Ashley E. ^{1, 6, 7}, Hommel, Jonathan D. ^{1, 6}, Lichti, Cheryl F. ^{1, 2}, Rudra, Jai S. ¹, D’Ascenzo, Marcello ⁹, Green, Thomas A. ^{1, 6}, Laezza, Fernanda ^{1, 2, 6, 13, ∗}

Source: In Cell Reports 10 April 2018 23(2):555-567

The mechanism underlying transient weakness in myotonia congenita

Authors: Jessica H Myers, Kirsten Denman, Chris DuPont, Ahmed A Hawash, Kevin R Novak, Andrew Koesters, Manfred Grabner, Anamika Dayal, Andrew A Voss, Mark M Rich

Source: eLife, Vol 10 (2021)

Subject Terms: muscle fiber, myotonia, sodium channel, calcium channel, persistent sodium current, excitability, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/65691; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/f201e13c4e5f4c20b08b45b730d90c95

Na+ -activated K+ channels protect against overexcitation and seizure-like behavior in Drosophila

Authors: Byers, Nathan S., author, Tsunoda, Susan, advisor, Garrity, Deborah, committee member, Hentges, Shane, committee member, Hoerndli, Frederic, committee member, Tamkun, Michael, committee member

Subject Terms: ion channels, sodium-activated potassium channels, persistent sodium current, epilepsy

File Description: born digital; doctoral dissertations; application/pdf

Relation: 2020-; Byers_colostate_0053A_16493.pdf; https://hdl.handle.net/10217/232596

Availability: https://hdl.handle.net/10217/232596

Enhancement of dendritic persistent Na+ currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision

Authors: Weonjin Yu, Jong-Woo Sohn, Jaehan Kwon, Suk-Ho Lee, Sooyun Kim, Won-Kyung Ho

Source: Molecular Brain, Vol 11, Iss 1, Pp 1-10 (2018)

Subject Terms: mGluR5-dependent plasticity, Persistent sodium current, CA1 pyramidal neurons, Intrinsic excitability, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13041-018-0410-7; https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/310b2dccc9384aaab3cc881b66f63fac

Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling study

Authors: Dougalis, AG, Matthews, GAC, Liss, B, Ungless, MA

Contributors: The Royal Society

Source: J Comput Neurosci

Subject Terms: Dorsal Raphe Nucleus, 0301 basic medicine, Patch-Clamp Techniques, Cognitive Neuroscience, Models, Neurological, Action Potentials, In Vitro Techniques, Persistent sodium current, 09 Engineering, Article, Membrane Potentials, 17 Psychology And Cognitive Sciences, Cellular and Molecular Neuroscience, 03 medical and health sciences, Autorhythmicity, Humans, Periaqueductal Gray, Depolarization block, Neurons, 0303 health sciences, Neurology & Neurosurgery, Dopaminergic Neurons, 11 Medical And Health Sciences, Delayed rectifier, Sensory Systems, Electrophysiology, Calcium

Access URL: https://link.springer.com/content/pdf/10.1007%2Fs10827-017-0641-0.pdf
https://pubmed.ncbi.nlm.nih.gov/28367595
http://hdl.handle.net/10044/1/45560