Over-excitation of tyrosine hydroxylase neurons in the paraventricular nucleus of the hypothalamus drives a neuroimmune positive feedback loop in rheumatoid arthritis.

Authors: Li H; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China., Yu H; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China. Electronic address: yhlzyn@hebut.edu.cn., Zhao X; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China., Xu J; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China; State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, China; Hebei Key Laboratory of Bioelectromagnetics and Neuroengineering, Hebei University of Technology, Tianjin 300130, China.

Source: Journal of neuroimmunology [J Neuroimmunol] 2025 Dec 15; Vol. 409, pp. 578773. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/immunology , Paraventricular Hypothalamic Nucleus*/enzymology , Paraventricular Hypothalamic Nucleus*/metabolism , Tyrosine 3-Monooxygenase*/metabolism , Neurons*/immunology , Neurons*/metabolism , Neurons*/enzymology , Arthritis, Rheumatoid*/immunology , Arthritis, Rheumatoid*/metabolism , Arthritis, Experimental*/immunology , Arthritis, Experimental*/metabolism , Feedback, Physiological*/physiology , Neuroimmunomodulation*/physiology, Animals ; Mice ; Male ; Mice, Inbred C57BL

Paraventricular nucleus neurons: important regulators of respiratory movement in mice with chronic intermittent hypoxia.

Authors: Liu L; Department of Geriatrics, The First Affiliated Hospital, Army Medical University, Chongqing, China., Zhang J; Department of Geriatrics, The First Affiliated Hospital, Army Medical University, Chongqing, China., Song S; Department of Geriatrics, The First Affiliated Hospital, Army Medical University, Chongqing, China., Li W; Department of Geriatrics, The First Affiliated Hospital, Army Medical University, Chongqing, China., Xiong W; Department of Geriatrics, The First Affiliated Hospital, Army Medical University, Chongqing, China.

Source: Annals of medicine [Ann Med] 2025 Dec; Vol. 57 (1), pp. 2588664. Date of Electronic Publication: 2025 Nov 18.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8906388 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2060 (Electronic) Linking ISSN: 07853890 NLM ISO Abbreviation: Ann Med Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/physiopathology , Paraventricular Hypothalamic Nucleus*/metabolism , Hypoxia*/physiopathology , Neurons*/metabolism , Neurons*/physiology , Sleep Apnea, Obstructive*/physiopathology, Animals ; Mice ; Disease Models, Animal ; Male ; Respiration ; Plethysmography, Whole Body ; Proto-Oncogene Proteins c-fos/metabolism ; Mice, Inbred C57BL ; Respiratory Center/physiopathology

Three-dimensional quantification of oxytocin neurons in the hypothalamic paraventricular nucleus reveals sex- and subregion-specific differences in two genetic mouse models of autism.

Authors: Patwardhan A; Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Canada., Li S; Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Canada., Chen J; Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Canada., Choe KY; Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, Canada.

Source: Journal of neuroendocrinology [J Neuroendocrinol] 2025 Dec; Vol. 37 (12), pp. e70092. Date of Electronic Publication: 2025 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: Wiley & Sons Country of Publication: United States NLM ID: 8913461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2826 (Electronic) Linking ISSN: 09538194 NLM ISO Abbreviation: J Neuroendocrinol Subsets: MEDLINE

MeSH Terms: Oxytocin*/metabolism , Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/pathology , Neurons*/metabolism , Neurons*/pathology , Sex Characteristics* , Autistic Disorder*/metabolism , Autistic Disorder*/genetics , Autism Spectrum Disorder*/metabolism , Autism Spectrum Disorder*/genetics, Animals ; Male ; Mice ; Female ; Disease Models, Animal ; Mice, Knockout ; Fragile X Mental Retardation Protein/genetics ; Nerve Tissue Proteins/genetics ; Membrane Proteins/genetics ; Imaging, Three-Dimensional ; Mice, Inbred C57BL

Chemogenetic inhibition of corticotropin releasing hormone neurons in the paraventricular nucleus attenuates traumatic stress-induced deficit of NREM sleep, but not REM sleep in mice.

Authors: Kostin A; Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, CA, USA., Suntsova N; Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, CA, USA.; Department of Medicine, University of California, Los Angeles, CA, USA., Kumar S; Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, CA, USA., Gvilia I; Research Service, Veterans Affairs Greater Los Angeles Healthcare System, North Hills, CA, USA.; Department of Medicine, University of California, Los Angeles, CA, USA.; Ilia State University, Tbilisi, Georgia.

Source: Stress (Amsterdam, Netherlands) [Stress] 2025 Dec; Vol. 28 (1), pp. 2465393. Date of Electronic Publication: 2025 Feb 16.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9617529 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1607-8888 (Electronic) Linking ISSN: 10253890 NLM ISO Abbreviation: Stress Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/physiopathology , Corticotropin-Releasing Hormone*/metabolism , Corticotropin-Releasing Hormone*/genetics , Neurons*/metabolism , Neurons*/physiology , Sleep, REM*/physiology , Sleep Initiation and Maintenance Disorders*/etiology , Sleep Initiation and Maintenance Disorders*/physiopathology, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Clozapine/analogs & derivatives ; Clozapine/pharmacology ; Odorants ; Chemogenetics

Apelin Regulates PVN Dopaminergic Activity and Limits Weight Gain in Mice: An Effect Attenuated by High-Fat Diet.

Authors: Cimen YA; Department of Physiology, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye.; Department of Physiology, Faculty of Medicine, Yalova University, Yalova, Türkiye.; Department of Physiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Türkiye., Yavuz Y; Department of Physiology, Faculty of Medicine, Yeditepe University, Istanbul, Türkiye.; Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Erdogan CS; Department of Physiology, Faculty of Medicine, Yeditepe University, Istanbul, Türkiye., Karakaya-Cimen FB; Department of Histology and Embryology, Faculty of Medicine, Yalova University, Yalova, Türkiye., Yilmaz B; Department of Physiology, Faculty of Medicine, Yeditepe University, Istanbul, Türkiye. bayram2353@yahoo.com.; Department of Physiology, Faculty of Medicine, Dokuz Eylül University, Izmir, Türkiye. bayram2353@yahoo.com.; Izmir Biomedicine and Genome Center, Izmir, Türkiye. bayram2353@yahoo.com., Kutlu S; Department of Physiology, Faculty of Medicine, Necmettin Erbakan University, Konya, Türkiye. skutlu@erbakan.edu.tr.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Nov 22; Vol. 63 (1), pp. 141. Date of Electronic Publication: 2025 Nov 22.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Diet, High-Fat*/adverse effects , Apelin*/pharmacology , Weight Gain*/drug effects , Weight Gain*/physiology , Dopamine*/metabolism , Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/drug effects , Dopaminergic Neurons*/metabolism , Dopaminergic Neurons*/drug effects, Animals ; Male ; Mice, Inbred C57BL ; Mice ; Apelin Receptors/metabolism ; Eating/drug effects ; Tyrosine 3-Monooxygenase/metabolism ; Body Weight/drug effects

Characterization of Perineuronal Nets in the Paraventricular Nucleus of the Hypothalamus and their Alteration in Neurogenic Hypertension.

Authors: Blanco I; Vanderbilt University Medical Center, 2220 Pierce Ave, RRB-536, Nashville, TN, 37232, USA. ismary.blanco@vumc.org., Chen S; Vanderbilt University, 2201 W End Ave, Nashville, TN, 37235, USA., Yeo E; Vanderbilt University, 2201 W End Ave, Nashville, TN, 37235, USA., Reasonover S; Vanderbilt University Medical Center, 2220 Pierce Ave, RRB-536, Nashville, TN, 37232, USA., Santisteban MM; Vanderbilt University Medical Center, 2220 Pierce Ave, RRB-536, Nashville, TN, 37232, USA. monica.santisteban@vumc.org.; Vanderbilt University, 2201 W End Ave, Nashville, TN, 37235, USA. monica.santisteban@vumc.org.

Source: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2025 Nov 17; Vol. 45 (1), pp. 105. Date of Electronic Publication: 2025 Nov 17.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8200709 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6830 (Electronic) Linking ISSN: 02724340 NLM ISO Abbreviation: Cell Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/pathology , Paraventricular Hypothalamic Nucleus*/metabolism , Hypertension*/pathology , Hypertension*/metabolism , Hypertension*/physiopathology , Nerve Net*/pathology , Nerve Net*/metabolism, Animals ; Male ; Female ; Neurons/metabolism ; Neurons/pathology ; Mice, Inbred C57BL ; Mice ; Oxytocin/metabolism ; Nitric Oxide Synthase Type I/metabolism ; Blood Pressure/physiology

Salt-inducible kinase 1 and CREB-regulated transcription co-activator 1 in the paraventricular nucleus participate in the antidepressant-like mechanism of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine in mice.

Authors: Qian JJ; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China., Zhang F; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China., Chen WJ; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China., Zhu BL; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China., Jin FY; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China; Office of Research and Innovation, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, Henan, China., Shen JY; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China; Office of Research and Innovation, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, Henan, China., Jiang B; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China. Electronic address: jiangbo78099@ntu.edu.cn., Fan H; Office of Research and Innovation, The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, Henan, China. Electronic address: fanhua19851229@126.com.

Source: Neuropharmacology [Neuropharmacology] 2025 Nov 15; Vol. 279, pp. 110632. Date of Electronic Publication: 2025 Aug 09.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/drug effects , Paraventricular Hypothalamic Nucleus*/metabolism , Antidepressive Agents*/pharmacology , Ketamine*/analogs & derivatives , Ketamine*/pharmacology , Transcription Factors*/metabolism , Transcription Factors*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics , Depression*/drug therapy , Depression*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Disease Models, Animal

Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve-neutrophil axis.

Authors: Li H; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China. lihui_1166@csu.edu.cn.; Anesthesiology Research Institute, Central South University, Changsha, China. lihui_1166@csu.edu.cn., Liu T; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Anesthesiology Research Institute, Central South University, Changsha, China., Wang Y; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Anesthesiology Research Institute, Central South University, Changsha, China., Miao XM; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Anesthesiology Research Institute, Central South University, Changsha, China., Xiong YY; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Anesthesiology Research Institute, Central South University, Changsha, China., Zhao Q; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Anesthesiology Research Institute, Central South University, Changsha, China., Shen WY; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China.; Anesthesiology Research Institute, Central South University, Changsha, China., Su FH; Department of Intensive Care, Erasmus Hospital, Brussels, Belgium., Chen K; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA., Dai RP; Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, China. xyeyyrupingdai@csu.edu.cn.; Anesthesiology Research Institute, Central South University, Changsha, China. xyeyyrupingdai@csu.edu.cn.

Source: Nature communications [Nat Commun] 2025 Oct 06; Vol. 16 (1), pp. 8870. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/cytology , Acute Lung Injury*/metabolism , Acute Lung Injury*/immunology , Acute Lung Injury*/pathology , Corticotropin-Releasing Hormone*/metabolism , Neurons*/metabolism , Sympathetic Nervous System*/metabolism , Neutrophils*/metabolism , Neutrophils*/immunology, Animals ; Male ; Mice ; Lung/innervation ; Lung/metabolism ; Lung/pathology ; Lung/immunology ; Mice, Inbred C57BL ; Signal Transduction ; NF-kappa B/metabolism ; Norepinephrine/metabolism ; Respiratory Distress Syndrome/immunology

Acute stress facilitates glutamatergic long-term potentiation of hypothalamic paraventricular nucleus magnocellular neurons via activation of β1-adrenergic receptors in rats in vivo.

Authors: Zhang YD; Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji City.; Department of Neural Circuit, Institute of Brain Science., Weng WC; Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji City.; Department of Neural Circuit, Institute of Brain Science., Liu Y; Department of Neural Circuit, Institute of Brain Science.; Department of Physiology, College of Basic Medicine, Jilin Medical University, Jilin City., Gao JT; Department of Neural Circuit, Institute of Brain Science.; Department of Physiology, College of Basic Medicine, Jilin Medical University, Jilin City., Li YZ; Department of Cardiology, Affiliated Hospital of Yanbian University, Yanji City, Jilin Province, China., Chu CP; Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji City.; Department of Neural Circuit, Institute of Brain Science.; Department of Physiology, College of Basic Medicine, Jilin Medical University, Jilin City., Qiu DL; Department of Physiology and Pathophysiology, College of Medicine, Yanbian University, Yanji City.; Department of Neural Circuit, Institute of Brain Science.; Department of Physiology, College of Basic Medicine, Jilin Medical University, Jilin City.

Source: Neuroreport [Neuroreport] 2025 Oct 01; Vol. 36 (14), pp. 847-855. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100935 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-558X (Electronic) Linking ISSN: 09594965 NLM ISO Abbreviation: Neuroreport Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/drug effects , Paraventricular Hypothalamic Nucleus*/physiopathology , Long-Term Potentiation*/physiology , Long-Term Potentiation*/drug effects , Neurons*/drug effects , Neurons*/metabolism , Neurons*/physiology , Receptors, Adrenergic, beta-1*/metabolism , Stress, Psychological*/physiopathology , Stress, Psychological*/metabolism , Glutamic Acid*/metabolism, Animals ; Male ; Rats ; Excitatory Postsynaptic Potentials/physiology ; Excitatory Postsynaptic Potentials/drug effects ; Rats, Sprague-Dawley ; Electric Stimulation

Leptin action on ARC-PVN neural circuit regulates ejaculation behavior by altering sympathetic neuroplasticity.

Authors: Zhang QJ; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.; Department of Urology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China., Luan JC; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Gu Q; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Song NH; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Xia JD; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Source: Andrology [Andrology] 2025 Oct; Vol. 13 (7), pp. 1866-1879. Date of Electronic Publication: 2025 Jan 03.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101585129 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-2927 (Electronic) Linking ISSN: 20472919 NLM ISO Abbreviation: Andrology Subsets: MEDLINE

MeSH Terms: Neuronal Plasticity*/drug effects , Neuronal Plasticity*/physiology , Ejaculation*/drug effects , Ejaculation*/physiology , Paraventricular Hypothalamic Nucleus*/drug effects , Paraventricular Hypothalamic Nucleus*/physiology , Leptin*/pharmacology , Leptin*/administration & dosage , Arcuate Nucleus of Hypothalamus*/drug effects , Arcuate Nucleus of Hypothalamus*/physiology , Sympathetic Nervous System*/drug effects , Sympathetic Nervous System*/physiology , Sexual Behavior, Animal*/drug effects, Animals ; Male ; Mice ; Mice, Inbred C57BL

Combined Study of Behavior and Spike Discharges Associated with Negative Emotions in Mice.

Authors: Xin J; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China., Wang X; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China.; Institute of Advanced Technology, University of Science and Technology of China, Hefei, 230026, China., Meng X; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China., Liu L; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China., Liu M; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China., Xiong H; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China., Liu A; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China. aipingl@ustc.edu.cn., Liu J; National Engineering Laboratory for Brain-inspired Intelligence Technology and Application, School of Information Science and Technology, University of Science and Technology of China, Hefei, 230026, China. lj1257@ustc.edu.cn.; CAS Key Laboratory of Brain Function and Diseases, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. lj1257@ustc.edu.cn.; MoE Key Laboratory of Brain-inspired Intelligent Perception and Cognition, University of Science and Technology of China, Hefei, 230026, China. lj1257@ustc.edu.cn.

Source: Neuroscience bulletin [Neurosci Bull] 2025 Oct; Vol. 41 (10), pp. 1843-1860. Date of Electronic Publication: 2025 Jul 15.

Publication Type: Journal Article

Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE

MeSH Terms: Emotions*/physiology , Stress, Psychological*/physiopathology , Action Potentials*/physiology , Behavior, Animal*/physiology , Amygdala*/physiology , Amygdala*/physiopathology , Paraventricular Hypothalamic Nucleus*/physiology , Paraventricular Hypothalamic Nucleus*/physiopathology , Brain*/physiology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Machine Learning ; Neurons/physiology

Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD.

Authors: Liu S; Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.; State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 210096, China., Yang Q; Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.; State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 210096, China., Zhu P; Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China.; State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 210096, China., Liu X; Department of Biochemistry and Molecular Biology, Medical School of Southeast University, Nanjing, 210009, China., Lu Q; Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210009, China., Yang J; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, 325000, China., Gao J; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, 325000, China., Han H; Department of Radiology, Beijing Key Laboratory of Magnetic Resonance Imaging Devices and Technology, Peking University Third Hospital, Beijing, 100191, China., Zhang Z; Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210009, China. janemengzhang@vip.163.com.; Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Department of Mental Health and Public Health, Faculty of Life and Health Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. janemengzhang@vip.163.com., Gu N; Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine, Institute of Clinical Medicine, Medical School, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, 210093, China. guning@nju.edu.cn., Tan T; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, 325000, China. sunzaghi@seu.edu.cn., Sun J; Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210009, China. sunzaghi@seu.edu.cn.; State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 210096, China. sunzaghi@seu.edu.cn.

Source: Neuroscience bulletin [Neurosci Bull] 2025 Oct; Vol. 41 (10), pp. 1711-1728. Date of Electronic Publication: 2025 Aug 04.

Publication Type: Journal Article

Journal Info: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 101256850 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1995-8218 (Electronic) Linking ISSN: 19958218 NLM ISO Abbreviation: Neurosci Bull Subsets: MEDLINE

MeSH Terms: Autism Spectrum Disorder*/therapy , Autism Spectrum Disorder*/physiopathology , Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/physiopathology , Paraventricular Hypothalamic Nucleus*/physiology , Transcranial Magnetic Stimulation*/methods , Social Behavior*, Animals ; Disease Models, Animal ; Male ; Mice ; Oxytocin/metabolism ; Mice, Inbred C57BL ; Neurons/metabolism ; Neurons/physiology

Sonogenetic neuromodulation prevents post-myocardial infarction malignant arrhythmia and cardiac remodeling through the brain-heart circuit.

Authors: Hu H; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China., Hu C; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China., Cheng X; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China., Wang J; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China., Guo W; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China., Cheng Y; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China., Jiang H; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China. hong-jiang@whu.edu.cn., Wang S; Cardiovascular Hospital, Renmin Hospital of Wuhan University; Cardiac Autonomic Nervous System Research Center of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, 430061, China. songyunwang@whu.edu.cn.

Source: Basic research in cardiology [Basic Res Cardiol] 2025 Oct; Vol. 120 (5), pp. 1037-1054. Date of Electronic Publication: 2025 Jul 09.

Publication Type: Journal Article

Journal Info: Publisher: Steinkopff Country of Publication: Germany NLM ID: 0360342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1803 (Electronic) Linking ISSN: 03008428 NLM ISO Abbreviation: Basic Res Cardiol Subsets: MEDLINE

MeSH Terms: Ventricular Remodeling* , Myocardial Infarction*/complications , Myocardial Infarction*/physiopathology , Myocardial Infarction*/metabolism , Arrhythmias, Cardiac*/prevention & control , Arrhythmias, Cardiac*/physiopathology , Arrhythmias, Cardiac*/metabolism , Arrhythmias, Cardiac*/etiology , Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/physiopathology , Potassium Channels*/genetics , Potassium Channels*/metabolism, Animals ; Male ; Disease Models, Animal ; Rats, Sprague-Dawley ; Heart Rate ; Ventricular Function, Left

Apelin‑13 in the paraventricular nucleus (PVN) attenuates myocardial ischemia through V1a receptors in PVN/nucleus tractus solitarii (NTS) and GARγ2 in NTS.

Authors: Yan W; Department of Anesthesia, The Second Hospital of Jilin University, Changchun, Jilin 130021, P.R. China., Wang D; Department of Anesthesia, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China., Zhang X; Department of Anesthesia, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China., Xuan C; Department of Anesthesia, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Source: International journal of molecular medicine [Int J Mol Med] 2025 Dec; Vol. 56 (6). Date of Electronic Publication: 2025 Oct 03.

Publication Type: Journal Article

Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/metabolism , Receptors, Vasopressin*/metabolism , Receptors, Vasopressin*/genetics , Solitary Nucleus*/metabolism , Intercellular Signaling Peptides and Proteins*/metabolism , Intercellular Signaling Peptides and Proteins*/genetics , Intercellular Signaling Peptides and Proteins*/pharmacology , Myocardial Ischemia*/metabolism , Myocardial Ischemia*/physiopathology , Myocardial Ischemia*/pathology , Receptors, GABA-A*/metabolism , Receptors, GABA-A*/genetics, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Myocardial Infarction/metabolism ; Signal Transduction

Microneedle biosensor for real-time monitoring of hydrogen sulfide release from paraventricular nucleus of hypertension rats stimulated by electroacupuncture.

Authors: Pei J; School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China., Tang L; School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China; Hubei Shizhen Laboratory, Wuhan, 430061, PR China., Kang C; Department of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China., Shi F; School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China., Liang F; Department of Acupuncture and Moxibustion, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China. Electronic address: fxliang5@hotmail.com., Li Y; School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China; Hubei Shizhen Laboratory, Wuhan, 430061, PR China. Electronic address: lyt2015@hbucm.edu.cn., Zhang GJ; School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan, 430065, PR China; Hubei Shizhen Laboratory, Wuhan, 430061, PR China. Electronic address: zhanggj@hbucm.edu.cn.

Source: Talanta [Talanta] 2025 Nov 01; Vol. 294, pp. 128215. Date of Electronic Publication: 2025 Apr 30.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

MeSH Terms: Hydrogen Sulfide*/metabolism , Hydrogen Sulfide*/analysis , Biosensing Techniques*/instrumentation , Biosensing Techniques*/methods , Needles* , Hypertension*/metabolism , Hypertension*/therapy , Paraventricular Hypothalamic Nucleus*/metabolism , Electroacupuncture*, Animals ; Rats ; Male ; Metal Nanoparticles/chemistry ; Gold/chemistry ; Rats, Sprague-Dawley ; Disulfides/chemistry ; Molybdenum/chemistry ; Silver Compounds/chemistry

Obesity dysregulates feeding-evoked response dynamics in hypothalamic satiety neurons.

Authors: Porniece M; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA., Baker J; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.; Center for Neural Science, New York University, NY, 10003, New York, USA., Ausfahl CD; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA., Zhang SX; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA. xz5184@nyu.edu.; Center for Neural Science, New York University, NY, 10003, New York, USA. xz5184@nyu.edu., Andermann ML; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA. manderma@bidmc.harvard.edu.; Department of Neurobiology, Harvard Medical School, MA, 02115, Boston, USA. manderma@bidmc.harvard.edu.

Source: Scientific reports [Sci Rep] 2025 Oct 14; Vol. 15 (1), pp. 35837. Date of Electronic Publication: 2025 Oct 14.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Obesity*/physiopathology , Obesity*/metabolism , Obesity*/etiology , Neurons*/metabolism , Neurons*/physiology , Hypothalamus*/metabolism , Satiety Response*/physiology , Feeding Behavior*/physiology , Paraventricular Hypothalamic Nucleus*/metabolism, Animals ; Diet, High-Fat/adverse effects ; Mice ; Male ; Receptor, Melanocortin, Type 4/metabolism ; Mice, Inbred C57BL ; Satiation ; Eating/physiology

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake.

Authors: Rea JJ; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA; Neuroscience Graduate Program, University of Southern California, USA., Liu CM; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA; Neuroscience Graduate Program, University of Southern California, USA., Hayes AMR; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA., Ohan R; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA., Schwartz GM; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA., Bashaw AG; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA; Neuroscience Graduate Program, University of Southern California, USA., Klug ME; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA., Decarie-Spain L; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA., Park Y; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA., Kao AE; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA., Grinevich V; Department of Neuropeptide Research for Psychiatry, Central Institute of Mental Health, German Center for Psychiatry (DZPG), University of Heidelberg, Mannheim, Germany., Kanoski SE; Human and Evolutionary Biology Section, Department of Biological Sciences, Dornsife College of Letters, Arts and Sciences, University of Southern California, USA; Neuroscience Graduate Program, University of Southern California, USA. Electronic address: kanoski@usc.edu.

Source: Molecular metabolism [Mol Metab] 2025 Oct; Vol. 100, pp. 102220. Date of Electronic Publication: 2025 Jul 23.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

MeSH Terms: Oxytocin*/metabolism , Paraventricular Hypothalamic Nucleus*/metabolism , Neurons*/metabolism , Eating*/physiology , Supraoptic Nucleus*/metabolism, Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Feeding Behavior/physiology

Neuromedin U in paraventricular nucleus enhances adipose afferent reflex and sympathoexcitation via the activation of receptor-ERK signaling pathway in rats with obesity-related hypertension.

Authors: Wang Q; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Zhu HX; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Gao Q; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Xia CX; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Cao WJ; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Chen AD; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Zhou YB; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China. Electronic address: zhouyebo666@njmu.edu.cn., Chen LL; Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 211166, China; Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210000, China. Electronic address: chenlei19762002@163.com.

Source: Neuropharmacology [Neuropharmacology] 2026 Feb 01; Vol. 283, pp. 110750. Date of Electronic Publication: 2025 Oct 26.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/drug effects , Paraventricular Hypothalamic Nucleus*/metabolism , Sympathetic Nervous System*/drug effects , Sympathetic Nervous System*/metabolism , Sympathetic Nervous System*/physiopathology , Obesity*/complications , Obesity*/metabolism , Obesity*/physiopathology , Hypertension*/metabolism , Hypertension*/etiology , Hypertension*/physiopathology , Neuropeptides*/pharmacology , Neuropeptides*/metabolism , Neuropeptides*/administration & dosage , MAP Kinase Signaling System*/drug effects , MAP Kinase Signaling System*/physiology , Reflex*/drug effects , Reflex*/physiology , Adipose Tissue*/drug effects, Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Heart Rate/drug effects ; Heart Rate/physiology ; Blood Pressure/drug effects ; Blood Pressure/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Diet, High-Fat/adverse effects ; Receptors, Neurotransmitter/metabolism

Glucoprivation-induced nutrient preference relies on distinct NPY neurons that project to the paraventricular nucleus of the hypothalamus.

Authors: Rattanajearakul N; Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences (NIPS), Okazaki, Aichi, 4448585, Japan; Laboratory of Alimentary Neuroscience, Department of Applied Life Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, 4648601, Japan., Kondoh K; Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences (NIPS), Okazaki, Aichi, 4448585, Japan; Division of Integrative Physiology, Department of Physiology, Faculty of Medicine, Tottori University, Yonago, 6838503, Japan., Fu O; Laboratory of Food Perception Science, Science Center for Future Foods, Jiangnan University, Wuxi, Jiangsu, 214122, China., Okamoto S; Laboratory of Veterinary Physiology and Biochemistry, Joint Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, 7538511, Japan., Kobayashi K; Section of Viral Vector Development, National Institute for Physiological Sciences (NIPS), Okazaki, Aichi, 4448585, Japan., Nakajima KI; Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences (NIPS), Okazaki, Aichi, 4448585, Japan; Laboratory of Alimentary Neuroscience, Department of Applied Life Sciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, 4648601, Japan. Electronic address: knakaj@agr.nagoya-u.ac.jp., Minokoshi Y; Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences (NIPS), Okazaki, Aichi, 4448585, Japan; Division of Nutritional Physiology, Sugiyama Jogakuen University School & Graduate School of Life Studies, Nagoya, Aichi, 4648662, Japan. Electronic address: minokosh@sugiyama-u.ac.jp.

Source: Metabolism: clinical and experimental [Metabolism] 2026 Jan; Vol. 174, pp. 156415. Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/metabolism , Paraventricular Hypothalamic Nucleus*/physiology , Paraventricular Hypothalamic Nucleus*/drug effects , Neurons*/metabolism , Neurons*/physiology , Neurons*/drug effects , Neuropeptide Y*/metabolism , Food Preferences*/physiology , Food Preferences*/drug effects, Animals ; Male ; Mice ; Diet, High-Fat ; Mice, Inbred C57BL ; Deoxyglucose/pharmacology ; Receptor, Melanocortin, Type 4/metabolism ; Corticotropin-Releasing Hormone/metabolism ; Neural Pathways/physiology

Identification and validation of Slit3 as a depression biomarker modulating dynorphinergic neurons in the hypothalamic paraventricular nucleus.

Authors: Jiang YH; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No.260 Baichuan Road, Fuyang District, Hangzhou, 311400, Zhejiang, China., Zhai CY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No.260 Baichuan Road, Fuyang District, Hangzhou, 311400, Zhejiang, China., Ying JN; Department of Neurobiology and Acupuncture Research, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China., Wu S; Department of Neurobiology and Acupuncture Research, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China., Liu JG; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No.260 Baichuan Road, Fuyang District, Hangzhou, 311400, Zhejiang, China; Department of Neurobiology and Acupuncture Research, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: jgliu@simm.ac.cn., Xu C; Department of Neurobiology and Acupuncture Research, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: xuchi@zcmu.edu.cn.

Source: Neuropharmacology [Neuropharmacology] 2026 Feb 01; Vol. 283, pp. 110765. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH Terms: Paraventricular Hypothalamic Nucleus*/metabolism , Neurons*/metabolism , Depression*/metabolism , Depression*/genetics , Nerve Tissue Proteins*/metabolism , Nerve Tissue Proteins*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/genetics, Animals ; Male ; Mice, Inbred C57BL ; Mice ; Biomarkers/metabolism ; Stress, Psychological/metabolism ; Proto-Oncogene Proteins c-fos/metabolism ; Social Defeat