The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR.

Συγγραφείς: Callahan A; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA., Mojumdar A; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, 02903, USA., Hu M; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, 02903, USA., Wang A; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA., Griffith AA; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA., Huang N; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA., Chua XY; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, 02903, USA., Mroz N; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA., Puterbaugh RZ; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, 02903, USA., Reilly SP; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA., Salomon A; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI, 02903, USA. art@drsalomon.com.; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, 02903, USA. art@drsalomon.com.

Πηγή: Scientific reports [Sci Rep] 2025 Jul 30; Vol. 15 (1), pp. 27747. Date of Electronic Publication: 2025 Jul 30.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Receptors, Antigen, T-Cell*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/genetics , T-Lymphocytes*/metabolism , T-Lymphocytes*/immunology , Protein Tyrosine Phosphatase, Non-Receptor Type 22*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 22*/genetics , Phosphotyrosine*/metabolism, Humans ; Jurkat Cells ; Feedback, Physiological ; Signal Transduction ; CRISPR-Cas Systems ; Protein Tyrosine Phosphatase, Non-Receptor Type 1

Pro-inflammatory cytokines as regulators of protein tyrosine phosphatases and insulin signaling in murine skeletal muscle cells.

Συγγραφείς: Stein V; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, 13353 Berlin, Germany; German Center for Cardiovascular Research (DZHK), partner site Berlin, Germany., Geserick P; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, 13353 Berlin, Germany., Friedrich K; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, 13353 Berlin, Germany., Brinschwitz B; Department of Internal Medicine B, Cardiology, University Medicine Greifswald, 17475 Greifswald, Germany; German Center for Cardiovascular Research (DZHK), partner site Greifswald, Germany., Musal IM; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, 13353 Berlin, Germany., Ulke J; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, 13353 Berlin, Germany., Fielitz J; Department of Internal Medicine B, Cardiology, University Medicine Greifswald, 17475 Greifswald, Germany; German Center for Cardiovascular Research (DZHK), partner site Greifswald, Germany., Kappert K; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Diagnostic Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, 13353 Berlin, Germany; German Center for Cardiovascular Research (DZHK), partner site Berlin, Germany. Electronic address: kai.kappert@charite.de.

Πηγή: Cellular signalling [Cell Signal] 2025 Nov; Vol. 135, pp. 112037. Date of Electronic Publication: 2025 Jul 31.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Signal Transduction*/drug effects , Insulin*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Cytokines*/metabolism , Cytokines*/pharmacology , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/cytology , Protein Tyrosine Phosphatases*/metabolism, Animals ; Mice ; Cell Line ; Interleukin-1beta/pharmacology ; Interleukin-6/pharmacology ; Tumor Necrosis Factor-alpha/pharmacology ; Insulin Resistance

Impact of C18 Epimerization of Indole- and Pyrazole-Fused 18β-Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies.

Συγγραφείς: De-la-Cruz-Martínez L; Doctorado en Ciencias Farmacéuticas, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco, Ciudad de México, 04960, Mexico.; Laboratorio de Síntesis y Aislamiento de Sustancias Bioactivas, Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco, Ciudad de México, 04960, Mexico.; Laboratorio de Biosensores y Modelaje Molecular, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico., Martínez-Arellano R; Laboratorio de Síntesis y Aislamiento de Sustancias Bioactivas, Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco, Ciudad de México, 04960, Mexico.; Red de apoyo a la Investigación, Universidad Nacional Autónoma de México, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, 14080, Mexico., López-Sánchez M; Laboratorio de Síntesis y Aislamiento de Sustancias Bioactivas, Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco, Ciudad de México, 04960, Mexico.; Red de apoyo a la Investigación, Universidad Nacional Autónoma de México, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, 14080, Mexico., Alvarado-Rodríguez JG; Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Hidalgo, 42184, Mexico., Torres-Valencia JM; Área Académica de Química, Universidad Autónoma del Estado de Hidalgo, Hidalgo, 42184, Mexico., Equihua-González D; Laboratorio de Síntesis y Aislamiento de Sustancias Bioactivas, Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco, Ciudad de México, 04960, Mexico., Almanza-Pérez JC; Laboratorio de Farmacología, Departamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Iztapalapa, Ciudad de México, 09340, Mexico., Pérez-Villanueva J; Laboratorio de Síntesis y Aislamiento de Sustancias Bioactivas, Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco, Ciudad de México, 04960, Mexico., González-Andrade M; Laboratorio de Biosensores y Modelaje Molecular, Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico., Páez-Franco JC; Red de apoyo a la Investigación, Universidad Nacional Autónoma de México, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, 14080, Mexico., Cortés-Benítez F; Laboratorio de Síntesis y Aislamiento de Sustancias Bioactivas, Departamento de Sistemas Biológicos, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Unidad Xochimilco, Ciudad de México, 04960, Mexico.

Πηγή: ChemMedChem [ChemMedChem] 2025 Nov 18; Vol. 20 (22), pp. e202500350. Date of Electronic Publication: 2025 Sep 14.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Glycyrrhetinic Acid*/chemistry , Glycyrrhetinic Acid*/analogs & derivatives , Glycyrrhetinic Acid*/pharmacology , Glycyrrhetinic Acid*/chemical synthesis , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Indoles*/chemistry , Indoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Molecular Structure ; Dose-Response Relationship, Drug

Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites.

Συγγραφείς: Bester SM; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Linwood R; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Kataoka R; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Wu WI; Pfizer Boulder Research and Development, Boulder, CO 80301, USA., Mou TC; Pfizer Boulder Research and Development, Boulder, CO 80301, USA.

Πηγή: Acta crystallographica. Section F, Structural biology communications [Acta Crystallogr F Struct Biol Commun] 2024 Sep 01; Vol. 80 (Pt 9), pp. 210-219. Date of Electronic Publication: 2024 Aug 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: John Wiley & Sons Inc Country of Publication: United States NLM ID: 101620319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2053-230X (Electronic) Linking ISSN: 2053230X NLM ISO Abbreviation: Acta Crystallogr F Struct Biol Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Catalytic Domain*, Humans ; Crystallography, X-Ray ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Binding Sites ; Models, Molecular ; Protein Binding ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Crystallization ; Apoenzymes/chemistry ; Apoenzymes/metabolism ; Apoenzymes/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism

PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression.

Συγγραφείς: Ross MO; Department of Chemistry, University of Chicago, Chicago, IL, USA. matthewross@uchicago.edu., Xie Y; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Owyang RC; Department of Chemistry, University of Chicago, Chicago, IL, USA., Ye C; Department of Chemistry, University of Chicago, Chicago, IL, USA., Zbihley ONP; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., Lyu R; Department of Chemistry, University of Chicago, Chicago, IL, USA., Wu T; Department of Chemistry, University of Chicago, Chicago, IL, USA., Wang P; Department of Chemistry, University of Chicago, Chicago, IL, USA., Karginova O; Department of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL, USA., Olopade OI; Department of Medicine, Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, IL, USA., Zhao M; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA., He C; Department of Chemistry, University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.; Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA. chuanhe@uchicago.edu.

Πηγή: Nature communications [Nat Commun] 2024 Aug 13; Vol. 15 (1), pp. 6947. Date of Electronic Publication: 2024 Aug 13.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): ErbB Receptors*/metabolism , ErbB Receptors*/genetics , Copper*/metabolism , Cyclic AMP Response Element-Binding Protein*/metabolism , Signal Transduction* , Copper Transporter 1*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics, Humans ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics ; Transcription, Genetic/drug effects

Marine alkaloid rigidin analogues as potential selective inhibitors of SHP1, a new strategy for cancer immunotherapeutics.

Συγγραφείς: Bhasin S; Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, India.; Department of Biotechnology, Delhi Technological University, Shahbad Daulatpur, Delhi, India., Das A; Department of Biotechnology, Delhi Technological University, Shahbad Daulatpur, Delhi, India.

Πηγή: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Jul; Vol. 42 (11), pp. 5590-5606. Date of Electronic Publication: 2023 Jun 22.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 6*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/antagonists & inhibitors , Molecular Dynamics Simulation* , Alkaloids*/chemistry , Alkaloids*/pharmacology, Humans ; Neoplasms/drug therapy ; Molecular Docking Simulation ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism ; Immunotherapy/methods ; Protein Binding ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Structure-Activity Relationship

Oral PTP1B siRNA Delivery Using Milk-Derived Extracellular Vesicles for Alleviation of Acute Kidney Injury.

Συγγραφείς: Jang H; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea., Park D; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea., Park B; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea., Ryu Y; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea., Ko YS; Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea., Lee HY; Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea., Choi YE; Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea., Oh SW; Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea., Jo SK; Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea., Sim J; Department of Pathology, Korea University College of Medicine, Seoul 02841, Republic of Korea., Choi J; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea., Jung Y; ATG Lifetech Inc, Seoul 08507, Republic of Korea., Ryu T; ATG Lifetech Inc, Seoul 08507, Republic of Korea., Shim MK; Medicinal Materials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea., Kim MG; Division of Nephrology, Department of Internal Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea., Yang Y; Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Πηγή: ACS nano [ACS Nano] 2025 Nov 25; Vol. 19 (46), pp. 40085-40099. Date of Electronic Publication: 2025 Nov 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Acute Kidney Injury*/therapy , Acute Kidney Injury*/pathology , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/genetics , Acute Kidney Injury*/drug therapy , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Extracellular Vesicles*/chemistry , Extracellular Vesicles*/metabolism , RNA, Small Interfering*/administration & dosage , RNA, Small Interfering*/genetics , Milk*/chemistry, Animals ; Mice ; Administration, Oral ; Humans ; Mice, Inbred C57BL ; Male ; Endoplasmic Reticulum Stress/drug effects

Development of Novel PTPN2/1 Inhibitors for the Treatment of Melanoma.

Συγγραφείς: Wang D; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Song M; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Tong C; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Wang W; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Li Q; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Liu J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Chen A; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Chen Y; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China., Wang L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Hao H; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Wang X; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China., Han K; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China., Xiao Y; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Kuang W; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Yang P; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China.

Πηγή: Journal of medicinal chemistry [J Med Chem] 2025 Oct 23; Vol. 68 (20), pp. 21917-21938. Date of Electronic Publication: 2025 Oct 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Melanoma*/drug therapy , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use, Animals ; Mice ; Humans ; Mice, Inbred C57BL ; Cell Line, Tumor ; Structure-Activity Relationship ; Melanoma, Experimental/drug therapy ; Melanoma, Experimental/pathology

PTPN2 acts as a tumor suppressor and therapeutic target in ovarian cancer.

Συγγραφείς: Sun X; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China; Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264003, China., Zhang W; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China., Wang H; Shaanxi University of Chinese Medicine, No.1, Middle Century Avenue, Chenyangzhai, Xianyang, Shaanxi, 712046, China., Hao J; Department of Pathology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264003, China., Shi W; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China., Lei P; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China; Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264003, China., Wei G; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China., Liu Y; Department of Pharmacology, School of Medicine, Southeast University, Dingjiaqiao 87, Nanjing, Jiangsu, 210009, China., Xu C; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China., Li L; Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, 264003, China. Electronic address: lilq2005@bzmc.edu.cn., Yu L; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China. Electronic address: Liting_Yu@bzmc.edu.cn., Zhang DL; Department of Protein and Antibody Engineering, School of Pharmacy, Binzhou Medical University, Yantai, Shandong, 264003, China. Electronic address: dlzhang@bzmc.edu.cn.

Πηγή: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2025 Oct 20; Vol. 785, pp. 152704. Date of Electronic Publication: 2025 Sep 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/drug therapy , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Genes, Tumor Suppressor* , Tumor Suppressor Proteins*/metabolism , Tumor Suppressor Proteins*/genetics, Humans ; Female ; Cell Line, Tumor ; Cell Proliferation ; Cell Movement ; Gene Expression Regulation, Neoplastic ; Biomarkers, Tumor/metabolism ; Biomarkers, Tumor/genetics

PTP1B deficiency in myeloid cells increases susceptibility to Candida albicans systemic infection by modulating antifungal immunity.

Συγγραφείς: Allen B; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Dambuza IM; MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom., Berry SH; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Reid DM; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., McVey SM; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Mesiarikova M; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., John L; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Davie M; Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom., Baker CP; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Arthur JSC; Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom., Delibegovic M; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.; Aberdeen Cardiovascular and Diabetes Centre, University of Aberdeen, Aberdeen, United Kingdom., Brown GD; MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom., Wilson HM; School of Medicine, Medical Sciences & Dentistry, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.

Πηγή: MBio [mBio] 2025 Oct 08; Vol. 16 (10), pp. e0151625. Date of Electronic Publication: 2025 Aug 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 1*/deficiency , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/immunology , Candida albicans*/immunology , Candidiasis*/immunology , Candidiasis*/microbiology , Myeloid Cells*/immunology , Myeloid Cells*/microbiology, Animals ; Mice ; Macrophages/immunology ; Macrophages/microbiology ; Humans ; Mice, Knockout ; Neutrophils/immunology ; Disease Susceptibility ; Mice, Inbred C57BL ; Phagocytosis ; Disease Models, Animal

SCR Disease Name: Systemic candidiasis

Insights into PTP1B inhibitors as antidiabetic agents: Current research and future perspectives.

Συγγραφείς: Haider AS; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, 226002, India., Ambatwar R; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, 226002, India., Khatik GL; Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, 226002, India. Electronic address: gopal.khatik@niperraebareli.edu.in.

Πηγή: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 05; Vol. 295, pp. 117791. Date of Electronic Publication: 2025 May 23.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Humans ; Structure-Activity Relationship ; Molecular Structure ; Animals ; Diabetes Mellitus, Type 2/drug therapy

Mechanism-Based Allosteric Inhibition of PTP1B by Prenylated Flavonoids from Glycyrrhiza echinata: In Vitro Experiments and in Silico Validation.

Συγγραφείς: Kamel EM; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt. emad.abdelhameed@science.bsu.edu.eg., Abdelrheem DA; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt., Ahmed NA; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt., Alshabrmi FM; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia., Aba Alkhayl FF; Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia., Alwaili MA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. BOX 84428, Riyadh, 11671, Saudi Arabia., Altoom NG; Department of Biology, King Khalid Military Academy, Riyadh, 11459, Saudi Arabia., Lamsabhi AM; Departamento de Química and Institute for Advanced Research in Chemical Science (IAdChem), Facultad de Ciencias, Universidad Autónoma de Madrid, Módulo 13, Madrid, 28049, Spain.

Πηγή: The protein journal [Protein J] 2025 Oct; Vol. 44 (5), pp. 526-549. Date of Electronic Publication: 2025 Jul 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: Netherlands NLM ID: 101212092 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8355 (Electronic) Linking ISSN: 15723887 NLM ISO Abbreviation: Protein J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Flavonoids*/chemistry , Flavonoids*/pharmacology , Glycyrrhiza*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology, Molecular Docking Simulation ; Humans ; Allosteric Regulation ; Prenylation ; Allosteric Site ; Kinetics

Novel azabicyclic series of potent SHP2 allosteric inhibitors.

Συγγραφείς: Sferrazza A; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy. Electronic address: a.sferrazza@irbm.com., Rossetti I; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Fabbrini D; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Torrente E; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Relitti N; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Ferrigno F; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Fezzardi P; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Iaccarino C; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Bisbocci M; Department of Translational Biology, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Cellucci A; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Ventre D; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Anzillotti L; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Palombo S; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Nibbio M; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Alli C; Department of Translational Biology, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Montalbetti C; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy., Toniatti C; CSO - IRBM S.p.A., 00071 Pomezia, Rome, Italy., Petrocchi A; Department of Drug Discovery, IRBM S.p.A., 00071 Pomezia, Rome, Italy.

Πηγή: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2025 Dec 15; Vol. 129, pp. 130383. Date of Electronic Publication: 2025 Aug 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 11*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/chemical synthesis , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Aza Compounds*/chemistry , Aza Compounds*/pharmacology , Aza Compounds*/chemical synthesis, Humans ; Structure-Activity Relationship ; Allosteric Regulation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Molecular Structure ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor

Phytochemical constituents of Hydrangea macrophylla var. acuminata leaves and their inhibitory activity against PTP1B and α-glucosidase.

Συγγραφείς: Pham TL; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea.; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea., Nguyen VP; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea., Nguyen TTA; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea., Min BS; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk, Republic of Korea., Kim JA; Vessel-Organ Interaction Research Center, VOICE (MRC), College of Pharmacy, Kyungpook National University, Daegu, Republic of Korea.; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea.

Πηγή: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2584940. Date of Electronic Publication: 2025 Nov 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , alpha-Glucosidases*/metabolism , Plant Leaves*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Phytochemicals*/isolation & purification , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/isolation & purification , Hydrangea*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/isolation & purification, Molecular Docking Simulation ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans

The pathogenic E139D mutation stabilizes a non-canonical active state of the multi-domain phosphatase SHP2.

Συγγραφείς: van Vlimmeren AE; Department of Chemistry, Columbia University, New York, New York, USA.; Department of Biological Sciences, Columbia University, New York, New York, USA., Jiang Z; Department of Chemistry, Columbia University, New York, New York, USA., Karandur D; Independent Researcher, San Francisco, California, USA., Applebaum Licht AT; Department of Chemistry, Columbia University, New York, New York, USA., Shah NH; Department of Chemistry, Columbia University, New York, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA.

Πηγή: Protein science : a publication of the Protein Society [Protein Sci] 2025 Dec; Vol. 34 (12), pp. e70373.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 11*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/chemistry , Protein Tyrosine Phosphatase, Non-Receptor Type 11*/metabolism, Humans ; Molecular Dynamics Simulation ; src Homology Domains ; Mutation ; Models, Molecular ; Catalytic Domain

Intestinal epithelial PTPN2 limits pathobiont colonization by immune-directed antimicrobial responses.

Συγγραφείς: Chatterjee P; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Spalinger MR; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Acevedo C; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Santos AN; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Gries CM; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Manz SM; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.; Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Canale V; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Shawki A; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Sayoc-Becerra A; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Lei H; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Crawford MS; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Eckmann L; Division of Gastroenterology, University of California, San Diego, La Jolla, CA, USA., Borneman J; Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, CA, USA., McCole DF; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.

Πηγή: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2559029. Date of Electronic Publication: 2025 Sep 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/immunology , Intestinal Mucosa*/microbiology , Intestinal Mucosa*/immunology , Epithelial Cells*/microbiology , Epithelial Cells*/immunology , Escherichia coli*/immunology , Escherichia coli*/growth & development , Escherichia coli Infections*/immunology , Escherichia coli Infections*/microbiology , Escherichia coli Infections*/genetics, Animals ; Mice, Knockout ; Mice ; Humans ; Cytokines/metabolism ; Mice, Inbred C57BL ; Gastrointestinal Microbiome ; Female ; Male

DARPP-32 is a novel regulator of M2-macrophage polarization: Sustains STAT6 phosphorylation by directly binding and inhibiting tyrosine phosphatase SHP-1.

Συγγραφείς: Chowdhury S; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India., Sethi A; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Srivastava S; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India., Upadhyay V; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Mishra S; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India., Shome A; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Singh AK; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Singh S; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India., Bhatt MLB; King George's Medical University, KGMU, Lucknow, 226003, India., Mishra A; King George's Medical University, KGMU, Lucknow, 226003, India., Trivedi AK; Division of Cancer Biology, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, UP, India. arun3vedi@cdri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. arun3vedi@cdri.res.in.

Πηγή: Oncogene [Oncogene] 2025 Dec; Vol. 44 (47), pp. 4639-4656. Date of Electronic Publication: 2025 Oct 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 6*/metabolism , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 6*/genetics , STAT6 Transcription Factor*/metabolism , STAT6 Transcription Factor*/genetics , Macrophages*/metabolism , Macrophages*/immunology , Dopamine and cAMP-Regulated Phosphoprotein 32*/metabolism , Dopamine and cAMP-Regulated Phosphoprotein 32*/genetics, Humans ; Animals ; Phosphorylation ; Mice ; Macrophage Activation ; Signal Transduction ; Janus Kinase 1/metabolism ; F-Box-WD Repeat-Containing Protein 7/genetics ; THP-1 Cells ; Cell Polarity

The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis.

Συγγραφείς: Chatterjee P; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Canale V; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., King SJ; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Shawki A; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Lei H; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Santos AN; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., Haddad M; Department of Biology, University of California, Riverside, Riverside, CA, USA., Gries C; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA., McGovern DPB; Department of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Borneman J; Department of Microbiology and Plant Pathology, University of California, Riverside, CA, USA., McCole DF; Division of Biomedical Sciences, University of California, Riverside, Riverside, CA, USA.

Πηγή: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2526136. Date of Electronic Publication: 2025 Jul 07.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 2*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Inflammatory Bowel Diseases*/genetics , Inflammatory Bowel Diseases*/microbiology , Cell Adhesion Molecules*/metabolism , Cell Adhesion Molecules*/genetics , Antigens, CD*/metabolism , Antigens, CD*/genetics, Humans ; Genetic Predisposition to Disease ; Polymorphism, Single Nucleotide ; Animals ; Mice ; Janus Kinases/metabolism ; Janus Kinases/genetics ; Alleles ; HT29 Cells ; Signal Transduction ; Mice, Knockout ; STAT Transcription Factors/metabolism ; STAT Transcription Factors/genetics ; Intestinal Mucosa/microbiology ; Epithelial Cells/microbiology ; GPI-Linked Proteins

Targeting Protein Tyrosine Phosphatase Nonreceptor Type 2 with a Novel Inhibitor for the Treatment of Melanoma.

Συγγραφείς: Kuang W; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Li Q; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Pharmacy, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Wang W; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Wang D; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Tong C; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Pharmacy, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Song M; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Han K; Tasly Academy, Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China., Liu J; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Chen A; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Chen Y; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China., Wang L; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Hao H; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China., Wang X; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China., Xiao Y; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China.; Department of Pharmacy, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China., Yang P; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.; Institute of Innovative Drug Discovery and Development, China Pharmaceutical University, Nanjing 211198, China.

Πηγή: Journal of medicinal chemistry [J Med Chem] 2025 Nov 27; Vol. 68 (22), pp. 24649-24671. Date of Electronic Publication: 2025 Nov 08.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 2*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 2*/metabolism , Melanoma*/drug therapy , Melanoma*/pathology , Melanoma*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/therapeutic use, Animals ; Humans ; Mice ; Cell Line, Tumor ; Structure-Activity Relationship ; Cell Proliferation/drug effects

Bioactivity-based molecular networking-guided identification of methyl rosmarinate from Orthosiphon aristatus as a PTP1B inhibitor that improves insulin sensitivity in diabetic mice.

Συγγραφείς: Xie B; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China., Zhu D; State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Li L; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China., Lou R; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China., Wang R; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China., Min J; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China., Ye Y; State Key Laboratory of Drug Research and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China., Ma X; The department of Endocrinology and Metabolism, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China. Electronic address: fccmaxj1@zzu.edu.cn., Lin L; State Key Laboratory of Mechanism and Quality of Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China; Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macau 999078, China. Electronic address: ligenl@um.edu.mo.

Πηγή: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2025 Nov 25; Vol. 148, pp. 157444. Date of Electronic Publication: 2025 Oct 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Urban & Fischer Verlag Country of Publication: Germany NLM ID: 9438794 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-095X (Electronic) Linking ISSN: 09447113 NLM ISO Abbreviation: Phytomedicine Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Insulin Resistance* , Diabetes Mellitus, Experimental*/drug therapy , Diabetes Mellitus, Type 2*/drug therapy , Hypoglycemic Agents*/pharmacology, Animals ; Mice ; Male ; Mice, Inbred C57BL ; Cell Line ; Diet, High-Fat ; Muscle Fibers, Skeletal/drug effects