Ebola virus nucleoprotein interaction with host protein phosphatase-1 regulates its dimerization and capsid formation

Authors: Ahmad, Asrar ^{1, ‡}, Tigabu, Bersabeh ^{2, ‡}, Ivanov, Andrey ^{1, ‡}, Jerebtsova, Marina ^{3, ‡}, Ammosova, Tatiana ^{1, 4}, Ramanathan, Palaniappan ^{2, 5}, Kumari, Namita ^{1, 3}, Brantner, Christine A. ⁶, Pietzsch, Colette A. ², Simhadri, Jyothirmai ¹, Abdullah, Ghadeer ⁷, Uversky, Vladmir N. ⁸, Paromov, Victor ⁹, Popratiloff, Anastas ⁶, Widen, Steve ¹⁰, Bukreyev, Alexander ^{2, 5, 11, ∗}, Nekhai, Sergei ^{1, 3, 4, ∗}

Source: In Journal of Biological Chemistry June 2025 301(6)

Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the PPP1R14B Gene Product in Multiple Cancers and Beyond

Authors: Masumi Eto

Source: Biomolecules ; Volume 15 ; Issue 3 ; Pages: 344

Subject Terms: cancer diagnosis, prognostic assessment, protein phosphatase-1, cell signaling, proteostasis

Subject Geographic: agris

File Description: application/pdf

Relation: https://dx.doi.org/10.3390/biom15030344

Availability: https://doi.org/10.3390/biom15030344

Genkwanin Suppresses Mitochondrial Dysfunction to Alleviate IL-1β-elicited Inflammation, Apoptosis, and Degradation of Extracellular Matrix in Chondrocytes Through Upregulating DUSP1

Authors: Kanna Xu, Haoran Wang, Zhongqing Wu

Source: Chinese Journal of Physiology, Vol 66, Iss 4, Pp 284-293 (2023)

Subject Terms: Inflammation, Physiology, Interleukin-1beta, Apoptosis, Dual Specificity Phosphatase 1, extracellular matrix degradation, inflammatory response, 3. Good health, Extracellular Matrix, Mitochondria, osteoarthritis, MicroRNAs, Chondrocytes, Adenosine Triphosphate, genkwanin, dual-specificity protein phosphatase-1, Osteoarthritis, QP1-981, Humans, Aged

Access URL: https://pubmed.ncbi.nlm.nih.gov/37635488
https://doaj.org/article/4067dd12e8a0449782893ddcd7585acc

Structural Optimization of 2,3-Dihydro-1H-cyclopenta[b]quinolines Targeting the Noncatalytic RVxF Site of Protein Phosphatase 1 for HIV‑1 Inhibition

Authors: Lin, Xionghao^{aff1, aff4}, Sajith, Ayyiliath M^aff2, Wang, Songping^aff1, Kumari, Namita^{aff1, aff5}, Choy, Meng S^aff6, Ahmad, Asrar^aff1, Cadet, Dana R.^aff3, Gu, Xinbin^aff4, Ivanov, Andrey I.^aff1, Peti, Wolfgang^aff6, Kulkarni, Amol^aff2, Nekhai, Sergei^{aff1, aff5}

Source: ACS Infectious Diseases. 6(12):3190-3211

Availability: https://pubs.acs.org/doi/10.1021/acsinfecdis.0c00511

Cell-Penetrating Peptide Based on Myosin Phosphatase Target Subunit Sequence Mediates Myosin Phosphatase Activity

Authors: Andrea Kiss, Mohamad Mahfood, Zsófia Bodogán, Zoltán Kónya, Bálint Bécsi, Ferenc Erdődi

Source: Biomolecules, Vol 15, Iss 5, p 705 (2025)

Subject Terms: myosin phosphatase, protein phosphatase-1 (PP1) catalytic subunit (PP1c), myosin phosphatase target subunit-1 (MYPT1), cell-penetrating MYPT1 peptide, transactivating transcriptional activator (TAT)-peptide, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-273X/15/5/705; https://doaj.org/toc/2218-273X

Access URL: https://doaj.org/article/d42ce47932024e988b951920b3dec1c5

Evaluation of In Vivo Biological Activity Profiles of Isoindole-1,3-dione Derivatives: Cytotoxicity, Toxicology, and Histopathology Studies

Authors: Aytekin Köse, Meltem Kaya, Canberk Tomruk, Yiǧit Uyanıkgil, Nurhan Kishalı, Yunus Kara, Gülşah Şanlı-Mohamed

Contributors: Sabire Yazıcı Fen Edebiyat Fakültesi

Source: ACS Omega

Subject Terms: Anticancer Activity, Cantharidin Analogs, Protein Phosphatase-1, 2,4-Dichlorophenoxyacetic Acid, Evaluation of In Vivo Biological Activity Profiles, 3. Good health, Inhibition

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/37033818
https://hdl.handle.net/20.500.12451/11068
https://hdl.handle.net/11454/102606
https://doi.org/10.1021/acsomega.3c00560
https://avesis.atauni.edu.tr/publication/details/9ccc446a-2679-434a-9a5e-8007c89a2064/oai

SKP2 Contributes to AKT Activation by Ubiquitination Degradation of PHLPP1, Impedes Autophagy, and Facilitates the Survival of Thyroid Carcinoma

Authors: Shao, Yuan ^{1, 4}, Ren, Wanli ^{1, 4}, Dai, Hao ¹, Yang, Fangli ¹, Li, Xiang ¹, Zhang, Shaoqiang ¹, Liu, Junsong ¹, Yao, Xiaobao ¹, Zhao, Qian ¹, Sun, Xin ², Zheng, Zhiwei ³, Xu, Chongwen ^{1, *}

Source: In Molecules and Cells June 2023 46(6):360-373

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Authors: Daniel A. Bonsor, Patrick Alexander, Kelly Snead, Nicole Hartig, Matthew Drew, Simon Messing, Lorenzo I. Finci, Dwight V. Nissley, Frank McCormick, Dominic Esposito, Pablo Rodriguez-Viciana, Andrew G. Stephen, Dhirendra K. Simanshu

Source: Nature Structural & Molecular Biology, vol 29, iss 10

Subject Terms: 0301 basic medicine, Biochemistry & Molecular Biology, MIGRATION, MAP Kinase Signaling System, Biophysics, PATHWAY, Proto-Oncogene Proteins p21(ras), Phosphoserine, 03 medical and health sciences, PROTEIN PHOSPHATASE-1, Protein Phosphatase 1, BINDING, REVEALS, Humans, CATALYTIC SUBUNIT, SPECIFICITY, MUTATION, Mitogen-Activated Protein Kinase Kinases, SHOC2, 0303 health sciences, Science & Technology, Noonan Syndrome, Intracellular Signaling Peptides and Proteins, Cell Biology, 3. Good health, MOTIF, ras Proteins, raf Kinases, Life Sciences & Biomedicine

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/36175670
https://discovery-pp.ucl.ac.uk/id/eprint/10160416/
https://escholarship.org/uc/item/4j17m0kc

Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs)

Authors: Fontanillo, Miriam ^a, Trebacz, Malgorzata ^{b, c}, Reinkemeier, Christopher D. ^a, Avilés Huerta, Daniela ^a, Uhrig, Ulrike ^d, Sehr, Peter ^d, Köhn, Maja ^{a, b, c, ⁎}

Source: In Bioorganic & Medicinal Chemistry 1 July 2022 65

Towards Dissecting the Mechanism of Protein Phosphatase‐1 Inhibition by Its C‐Terminal Phosphorylation

Authors: Salvi, Francesca, Hoermann, Bernhard, del Pino Garcia, Javier, Fontanillo, Miriam, Derua, Rita, Beullens, Monique, Bollen, Mathieu, Barabas, Orsolya, Koehn, Maja

Source: Chembiochem
'ChemBioChem ', vol: 22, pages: 834-838 (2021)
ChemBioChem

Subject Terms: Threonine, 0301 basic medicine, Biochemistry & Molecular Biology, MITOTIC EXIT, 3101 Biochemistry and cell biology, Protein Conformation, Chemistry, Medicinal, 0601 Biochemistry and Cell Biology, 03 medical and health sciences, Protein Domains, Protein Phosphatase 1, Serine, biomimetic synthesis, Humans, Pharmacology & Pharmacy, Phosphorylation, 3404 Medicinal and biomolecular chemistry, protein phosphatase-1 (PP1) regulation, 0303 health sciences, Science & Technology, ARREST, 0304 Medicinal and Biomolecular Chemistry, phosphorylation, Organic Chemistry, Intracellular Signaling Peptides and Proteins, PP1, DEPHOSPHORYLATION, Protein phosphatase-1 (PP1) regulation, Communications, 3. Good health, ALPHA, Biomimetic synthesis, peptides, Peptides, Life Sciences & Biomedicine, protein semisynthesis, Protein semisynthesis, Protein Binding

File Description: application/pdf; pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/33085143
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57837
https://www.ncbi.nlm.nih.gov/pubmed/33085143
https://europepmc.org/article/MED/33085143
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202000669
https://pubmed.ncbi.nlm.nih.gov/33085143/
https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.202000669

Phosphatase Regulator NIPP1 Restrains Chemokine-Driven Skin Inflammation

Authors: Iris Verbinnen, Marloes Jonkhout, Kifayathullah Liakath-Ali, Kathelijne Szekér, Mónica Ferreira, Shannah Boens, Raphael Rouget, Margareta Nikolic, Susan Schlenner, Aleyde Van Eynde, Mathieu Bollen

Source: Journal of Investigative Dermatology. 140:1576-1588

Subject Terms: Keratinocytes, 0301 basic medicine, NF-KAPPA-B, chemokines, Dermatitis, Dermatology, IMMUNITY, Mice, 03 medical and health sciences, PROTEIN PHOSPHATASE-1, Cell Adhesion, hair-follicle stem cells, Animals, Humans, 1112 Oncology and Carcinogenesis, PHOSPHORYLATION, Cell Proliferation, Mice, Knockout, 0303 health sciences, Science & Technology, Dermatology & Venereal Diseases, 3202 Clinical sciences, Intracellular Signaling Peptides and Proteins, protein phosphatase-1, 1103 Clinical Sciences, Alopecia, cytokines, Disease Models, Animal, inflammation, CELLS, NIPP1, Chemokines, Epidermis, Life Sciences & Biomedicine, Hair Follicle

Access URL: http://www.jidonline.org/article/S0022202X2030035X/pdf
https://pubmed.ncbi.nlm.nih.gov/31972250
https://www.jidonline.org/article/S0022-202X(20)30035-X/fulltext
https://pubmed.ncbi.nlm.nih.gov/31972250/
https://europepmc.org/article/MED/31972250
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371497
https://www.sciencedirect.com/science/article/abs/pii/S0022202X2030035X
https://www.jidonline.org/article/S0022-202X(20)30035-X/addons
https://lirias.kuleuven.be/handle/123456789/649048
https://doi.org/10.1016/j.jid.2020.01.008

Structural basis of ubiquitin‐independent PP1 complex disassembly by p97

Authors: van den Boom, Johannes, Marini, Guendalina, Meyer, Hemmo^{Aff1, IDEMBJ2022113110_cor3}, Saibil, Helen R^{Aff3, IDEMBJ2022113110_cor4}

Source: The EMBO Journal. 42(14)

LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction

Authors: Ma, Yawen ^{a, b, 1, 2}, Wang, Lihua ^{a, b, 1, 2}, He, Fanglin ^{a, b, 1, 2}, Yang, Jie ^{a, b}, Ding, Yi ^{a, b}, Ge, Shengfang ^{a, b}, Fan, Xianqun ^{a, b}, Zhou, Yixiong ^{a, b}, Xu, Xiaofang ^{a, b}, Jia, Renbing ^{a, b, ∗}

Source: In Cancer Letters 28 May 2021 506:67-82

Neuroproteomics

Authors: Williams, Kenneth R., Nairn, Angus C.

Subject Terms: R5-920, RC346-429, analgesia, quantitative phosphoproteomics, neurodegeneration, neuron, neuronal circuits, mating, sex-specific differences, AMPA receptor complex, parallel reaction monitoring, splicing, phosphorylation, peptidylglycine ?-amidating monooxygenase, pherophorin, Alzheimer’s disease, neuroscience, yohimbine, synapses, adolescence, conformational antibody, opioid receptors, protein interaction networks, Alzheimer’s Disease, transmembrane AMPA receptor regulatory protein, neuroproteome, ethanol, U1 snRNP, mass spectroscopy, morphine, protein phosphatase-1, neuroproteomics, axons, reinstatement, DIA, voltage gated channels, prohormone convertase, postsynaptic density, neuroimmune, dendrites, carboxypeptidase, GPCR signaling, CaMKII, FGF14, SynCAM, nicotinic receptor, synaptic plasticity, plasma, serum, corticosterone, dopamine, Receptor-type tyrosine-protein phosphatase zeta, Ptprz1, PRM, cell type, schizophrenia, laser capture microdissection, synapse specificity, LC-MS/MS, mouse, drug abuse, synaptic cleft, striatum, Cadm, cytokine, spinophilin, PSD, trans-synaptic adhesion, nicotine, proximity labeling, biomarkers, addiction, PKA, synapse, proteome, signal peptide, ventral tegmental area, protein aggregation, cerebrospinal fluid, bioinformatics, progressive ratio, interactome, subtilisin, affinity chromatography, basal ganglia, cocaine, targeted proteomics, postsynaptic, mass spectrometry, connectome, quantitative mass spectrometry, biotinylation, proteomics, amphetamine, autism, data-independent acquisition, excitatory/inhibitory tone, neuropeptidomics, matrix metalloproteinase, cilia, R-PTP-zeta, cognitive impairment, Medicine and Nursing

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/54529
https://mdpi.com/books/pdfview/book/2022

Inhibition of protein phosphatase-1 and -2A by ellagitannins: structure-inhibitory potency relationships and influences on cellular systems

Authors: Kónya, Zoltán, Bécsi, Bálint, Kiss, Andrea, Horváth, Dániel, Hadháziné Raics, Mária, Kövér, Katalin, E., Lontay, Beáta, Erdődi, Ferenc

Source: J Enzyme Inhib Med Chem
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 500-509 (2019)

Subject Terms: 0301 basic medicine, Magnetic Resonance Spectroscopy, Synaptosomal-Associated Protein 25, Cell Survival, RM1-950, Calorimetry, tellimagrandin i, Exocytosis, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, Protein Phosphatase 1, synaptosomal exocytosis, Animals, Humans, Elméleti orvostudományok, protein phosphatase-2a, Protein Phosphatase 2, Enzyme Inhibitors, Phosphorylation, Muscle, Skeletal, Cerebral Cortex, 0303 health sciences, mahtabin a, protein phosphatase-1, Orvostudományok, Surface Plasmon Resonance, Hydrolyzable Tannins, 3. Good health, Therapeutics. Pharmacology, Research Paper, HeLa Cells, Synaptosomes

File Description: application/pdf

Access URL: https://www.tandfonline.com/doi/pdf/10.1080/14756366.2018.1557653?needAccess=true
https://pubmed.ncbi.nlm.nih.gov/30696301
https://doaj.org/article/1ebea239b38c40f89067b205d3226b25
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352937/
https://pubmed.ncbi.nlm.nih.gov/30696301/
https://www.tandfonline.com/doi/full/10.1080/14756366.2018.1557653

Phosphorylated Peptide Derived from the Myosin Phosphatase Target Subunit Is a Novel Inhibitor of Protein Phosphatase-1

Authors: Zoltán Kónya, István Tamás, Bálint Bécsi, Beáta Lontay, Mária Raics, István Timári, Katalin E. Kövér, Ferenc Erdődi

Source: International Journal of Molecular Sciences, Vol 24, Iss 5, p 4789 (2023)

Subject Terms: protein phosphatase-1 (PP1), myosin phosphatase (MP), myosin phosphatase target subunit-1 (MYPT1), MYPT1 inhibitory peptide (P-Thr696-MYPT1 690−701 ), molecular docking, saturation transfer difference NMR, Biology (General), QH301-705.5, Chemistry, QD1-999

Relation: https://www.mdpi.com/1422-0067/24/5/4789; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/390707bae2ac45368e599b4fb0844f02

Availability: https://doi.org/10.3390/ijms24054789
https://doaj.org/article/390707bae2ac45368e599b4fb0844f02

Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters

Authors: Kracht, Matthias ¹, van den Boom, Johannes ¹, Seiler, Jonas ^{1, †}, Kröning, Alexander ¹, Kaschani, Farnusch ², Kaiser, Markus ², Meyer, Hemmo ^{1, ⁎}

Source: In Journal of Molecular Biology 20 November 2020 432(23):6061-6074

Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission

Authors: Karl Foley, Haider Altimimi, Hailong Hou, Yu Zhang, Cody McKee, Makaía M. Papasergi-Scott, Hongtian Yang, Abigail Mayer, Nancy Ward, David M. MacLean, Angus C. Nairn, David Stellwagen, Houhui Xia

Source: Frontiers in Synaptic Neuroscience, Vol 14 (2022)

Subject Terms: protein phosphatase-1, scaffolding protein, regulatory subunit, synaptic transmission, FRET-Förster resonance energy transfer, hippocampus, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnsyn.2022.1021832/full; https://doaj.org/toc/1663-3563

Access URL: https://doaj.org/article/c086457f6f344661aadfe21d54e67f5d

Spinophilin negatively controlled the function of transient receptor potential vanilloid 1 in dorsal root ganglia neurons of mice

Authors: Guo, Zhen ¹, Li, Hu-Ling ¹, Cao, Zheng, Suo, Zhan-Wei, Yang, Xian, Hu, Xiao-Dong ^∗

Source: In European Journal of Pharmacology 15 November 2019 863

Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1

Authors: Heroes, Ewald ^{1, 5}, Van der Hoeven, Gerd ¹, Choy, Meng S. ², Garcia, Javier del Pino ¹, Ferreira, Mónica ¹, Nys, Mieke ³, Derua, Rita ⁴, Beullens, Monique ¹, Ulens, Chris ³, Peti, Wolfgang ², Van Meervelt, Luc ⁵, Page, Rebecca ^{2, ∗}, Bollen, Mathieu ^{1, 6, ∗∗}

Source: In Structure 5 March 2019 27(3):507-518