First-in-Human Phase I Study of a CD16A Bispecific Innate Cell Engager, AFM24, Targeting EGFR-Expressing Solid Tumors

Authors: Anthony El-Khoueiry, Omar Saavedra, Jacob Thomas, Claire Livings, Elena Garralda, Gabriele Hintzen, Laura Kohlhas, Dessislava Vanosmael, Joachim Koch, Erich Rajkovic, Paulien Ravenstijn, Paolo Nuciforo, Todd A. Fehniger, Mark Foster, Melissa M. Berrien-Elliott, Susanne Wingert, Sina Stäble, Daniela Morales-Espinosa, Delcia Rivas, Michael Emig, Juanita Lopez

Contributors: Institut Català de la Salut, [El-Khoueiry A, Thomas J] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California. [Saavedra O] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Livings C] Drug Development Unit, Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, Sutton, United Kingdom. [Garralda E] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Hintzen G] Affimed GmbH, Mannheim, Germany, Vall d'Hebron Barcelona Hospital Campus

Source: Clin Cancer Res
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname

Subject Terms: Male, Adult, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Toxicity Tests::Maximum Tolerated Dose, Maximum Tolerated Dose, Other subheadings::Other subheadings::/therapeutic use, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::pruebas de toxicidad::dosis máxima tolerada, Otros calificadores::Otros calificadores::/uso terapéutico, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate, Clinical Trials: Immunotherapy, DISEASES::Neoplasms, Neoplasms, Antibodies, Bispecific, Humans, Aged, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos biespecíficos, Aged, 80 and over, Other subheadings::Other subheadings::Other subheadings::/drug therapy, Càncer - Tractament, Receptors, IgG, Middle Aged, Immunoglobulines - Ús terapèutic, Posologia, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata, Immunity, Innate, ErbB Receptors, Killer Cells, Natural, Immunitat, Treatment Outcome, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Bispecific, ENFERMEDADES::neoplasias, Female

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39846810
http://hdl.handle.net/11351/12972

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Authors: Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, Camille Stephan-Otto Attolini, Francisco D. M. Marques, Marta Kovatcheva, Evripidis Gavathiotis, Manuel Serrano

Contributors: Institut Català de la Salut, [López-Polo V, Stephan-Otto Attolini C] Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. [Maus M] Institute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Zacharioudakis E, Marques FDM] Department of Biochemistry, Department of Medicine, Department of Oncology, Montefiore Einstein Comprehensive Cancer Center, Institute for Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY, USA. [Lafarga M] Department of Anatomy and Cell Biology and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), University of CantabriaIDIVAL, Santander, Spain, Vall d'Hebron Barcelona Hospital Campus, Universidad de Cantabria

Source: Nat Commun
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Nature Communications, 2024, 15, 7378
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: ENFERMEDADES::afecciones patológicas, signos y síntomas::procesos patológicos::inflamación, 0301 basic medicine, Other subheadings::Other subheadings::Other subheadings::/genetics, Interferon-Induced Helicase, IFIH1, RNA, Mitochondrial, Science, Mitocondris, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate, Article, Mitochondrial Proteins, ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria, ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::citosol, Mice, 03 medical and health sciences, Cytosol, Otros calificadores::Otros calificadores::Otros calificadores::/genética, FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular, Humans, Animals, Receptors, Immunologic, ANATOMY::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytosol, Cellular Senescence, RNA, Double-Stranded, Adaptor Proteins, Signal Transducing, Inflammation, 0303 health sciences, RNA-Binding Proteins, Citoplasma, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata, Mitochondria, 3. Good health, Fenotip, PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence, Immunitat, Exoribonucleases, DEAD Box Protein 58, Inflamació - Aspectes genètics, Senescence-Associated Secretory Phenotype, ANATOMÍA::células::estructuras celulares::espacio intracelular::citoplasma::estructuras citoplasmáticas::orgánulos::mitocondrias, DISEASES::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation, Signal Transduction

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39191740
https://hdl.handle.net/11351/12613
https://hdl.handle.net/10902/33656
https://doaj.org/article/cc28ced0dc1b40c9bf6f25abf11bb830

Natural immunity to SARS-CoV-2 and breakthrough infections in vaccinated and unvaccinated patients with cancer

Authors: Alessio Cortellini, Juan Aguilar-Company, Ramon Salazar, Mark Bower, Ailsa Sita-Lumsden, Andrea Plaja, Alvin J. X. Lee, Alexia Bertuzzi, Carlo Tondini, Nikolaos Diamantis, Clara Martinez-Vila, Aleix Prat, Eleanor Apthorp, Alessandra Gennari, David J. Pinato

Contributors: Institut Català de la Salut, [Cortellini A] Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK. Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. [Aguilar-Company J] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Salazar R] Department of Medical Oncology, ICO L’Hospitalet, Oncobell Program (IDIBELL), CIBERONC, Hospitalet de Llobregat, Spain. [Bower M] Department of Oncology and National Centre for HIV Malignancy, Chelsea and Westminster Hospital, London, UK. [Sita-Lumsden A] Medical Oncology, Guy’s and St Thomas’ NHS Foundation Trust (GSTT), London, UK. [Plaja A] Medical Oncology Department, B-ARGO Group, IGTP, Catalan Institute of Oncology-Badalona, Badalona, Spain, Vall d'Hebron Barcelona Hospital Campus, Cortellini, A., Aguilar-Company, J., Salazar, R., Bower, M., Sita-Lumsden, A., Plaja, A., Lee, A. J. X., Bertuzzi, A., Tondini, C., Diamantis, N., Martinez-Vila, C., Prat, A., Apthorp, E., Gennari, A., Pinato, D. J.

Source: Br J Cancer
Articles publicats en revistes (Ciències Clíniques)
Dipòsit Digital de la UB
instname
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
British Journal of Cancer
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

Subject Terms: 0301 basic medicine, Càncer - Pacients, Coronavirus infections, Infeccions per coronavirus, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate, Article, DISEASES::Neoplasms, 03 medical and health sciences, COVID-19 Testing, 0302 clinical medicine, DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, Neoplasms, Immunitat natural, Humans, ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus, Vacunació, REINFECTION, Public health, SARS-CoV-2, Vaccination, Immunity, COVID-19, Cancer patients, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata, Immunity, Innate, 3. Good health, Malalts de càncer, Immunitat, Oncology, ENFERMEDADES::neoplasias, Hematologic Neoplasms, Reinfection, COVID-19 (Malaltia) - Vacunació

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/35995934
https://hdl.handle.net/2445/197335
https://hdl.handle.net/11351/8397
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11294
http://hdl.handle.net/10044/1/103451
https://discovery-pp.ucl.ac.uk/id/eprint/10155073/
http://hdl.handle.net/2445/197335

Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles

Authors: Giacomo Della Camera, Tinghao Liu, Wenjie Yang, Yang Li, Victor F. Puntes, Sabrina Gioria, Paola Italiani, Diana Boraschi

Contributors: Institut Català de la Salut, [Della Camera G] Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy. European Commission, Joint Research Centre (JRC), Ispra, Italy. [Liu T, Yang W, Li Y] Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, China. China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation (CNR, SIAT, SZN), SIAT, CAS, Shenzhen, China. [Puntes VF] Institut Català de Nanociència i Nanotecnologia (ICN2), Consejo Superior de Investigaciones Científicas (CSIC) and The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Spain. [Gioria S] European Commission, Joint Research Centre (JRC), Ispra, Italy. [Italiani P] Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy. Stazione Zoologica Anton Dohrn (SZN), Napoli, Italy. China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation (CNR, SIAT, SZN), IBBC, CNR, Napoli, Italy. [Boraschi D] Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy. Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, China. China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation (CNR, SIAT, SZN), SIAT, CAS, Shenzhen, China. Stazione Zoologica Anton Dohrn (SZN), Napoli, Italy. China-Italy Joint Laboratory of Pharmacobiotechnology for Medical Immunomodulation (CNR, SIAT, SZN), IBBC, CNR, Napoli, Italy, Vall d'Hebron Barcelona Hospital Campus, European Commission, Ministero dell'Istruzione, dell'Università e della Ricerca, Chinese Academy of Sciences, Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]

Source: Int J Mol Sci
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14655

Subject Terms: Lipopolysaccharides, 0301 basic medicine, innate memory, LPS, Innate memory, TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate, Article, Monocytes, 03 medical and health sciences, Immunitat natural, Immune Tolerance, innate immunity, nanoparticles, bacteria, monocytes, macrophages, Humans, Innate immunity, 0303 health sciences, Bacteria, Nanopartícules, Macrophages, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata, Immunity, Innate, 3. Good health, Cytokines, Nanoparticles, TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/36498992
https://hdl.handle.net/11351/8716
http://hdl.handle.net/10261/291096
https://hdl.handle.net/20.500.14243/452058
http://www.scopus.com/record/display.url?eid=2-s2.0-85143797171&origin=inward
https://doi.org/10.3390/ijms232314655
https://ddd.uab.cat/record/273649

Immunomodulatory Function of Polyvinylpyrrolidone (PVP)-Functionalized Gold Nanoparticles in Vibrio-Stimulated Sea Urchin Immune Cells

Authors: Andi Alijagic, Angela Bonura, Francesco Barbero, Victor F. Puntes, Francesco Gervasi, Annalisa Pinsino

Contributors: European Commission, Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Institut Català de la Salut, [Alijagic A, Bonura A, Pinsino A] Consiglio Nazionale delle Ricerche, Istituto per la Ricerca e l’Innovazione Biomedica (IRIB), 90146 Palermo, Italy. [Barbero F] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain. [Puntes VF] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Gervasi F] Specialistic Oncology Laboratory Unit, ARNAS Hospitals Civico Di Cristina e Benfratelli, 90127 Palermo, Italy, Vall d'Hebron Barcelona Hospital Campus

Source: Nanomaterials (Basel)
Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
instname
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
Nanomaterials (Basel) 11 (2021). doi:10.3390/nano11102646
info:cnr-pdr/source/autori:Alijagic A; Bonura A; Barbero F; Puntes VF; Gervasi F; Pinsino A/titolo:Immunomodulatory function of polyvinylpyrrolidone (PVP)-functionalized gold nanoparticles in vibrio-stimulated sea urchin immune cells/doi:10.3390%2Fnano11102646/rivista:Nanomaterials (Basel)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Nanomaterials, Vol 11, Iss 10, p 2646 (2021)
Nanomaterials
Volume 11
Issue 10

Subject Terms: Infected sea urchin immune cells, Nanointeraction, Proxy for human model, PVP–AuNPs antimicrobial function, Quiescence and immune activation, 0301 basic medicine, TECNOLOGÍA, INDUSTRIA Y AGRICULTURA::tecnología, industria y agricultura::productos manufacturados::nanoestructuras::nanopartículas::nanopartículas metálicas, nanointeraction, DISEASES::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Negative Bacterial Infections::Vibrio Infections, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate, Article, infected sea urchin immune cells, 03 medical and health sciences, TECHNOLOGY, INDUSTRY, AND AGRICULTURE::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles, PVP-AunNPs antimicrobial function, Immunitat natural, QD1-999, 0303 health sciences, Nanopartícules, sea urchin, immunity, nano safety, bacterial infection, quiescence and immune activation, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata, 3. Good health, Chemistry, Malalties bacterianes gramnegatives, ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias gramnegativas::vibriosis, proxy for human model, PVP-AuNPs antimicrobial function

File Description: application/pdf

Access URL: https://www.mdpi.com/2079-4991/11/10/2646/pdf
https://pubmed.ncbi.nlm.nih.gov/34685085
http://hdl.handle.net/10261/265001
https://hdl.handle.net/11351/7440
https://ddd.uab.cat/record/264926
https://doaj.org/article/99185e3fcc1541479dfed9fddfe11111
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539316
https://www.mdpi.com/2079-4991/11/10/2646/pdf
https://www.mdpi.com/2079-4991/11/10/2646

The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective

Authors: Lena Ernst, Eudald Casals, Paola Italiani, Diana Boraschi, Victor Puntes

Contributors: European Commission, Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72], Institut Català de la Salut, [Ernst LM] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Casals E] School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China. [Italiani P] Institute of Protein Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy. [Boraschi D] Institute of Protein Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Napoli, Italy. Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, China. Stazione Zoologica Anton Dohrn, Napoli, Italy. [Puntes V] Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, Barcelona, Spain. Institució Catalana de Recerca I Estudis Avançats (ICREA), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

Source: Nanomaterials (Basel)
Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Nanomaterials, Vol 11, Iss 11, p 2991 (2021)

Subject Terms: 0301 basic medicine, Review, 02 engineering and technology, Sistema immunològic, PHENOMENA AND PROCESSES::Immune System Phenomena::Immunity::Immunity, Innate, DISCIPLINAS Y OCUPACIONES::disciplinas de las ciencias naturales::nanotecnología::nanomedicina, 03 medical and health sciences, ANATOMÍA::sistemas sanguíneo e inmunológico::sistema inmunológico, ANATOMY::Hemic and Immune Systems::Immune System, innate immunity, QD1-999, Innate immunity, Inflammation, tolerance, FENÓMENOS Y PROCESOS::fenómenos del sistema inmunitario::inmunidad::inmunidad innata, 3. Good health, immune system, Chemistry, Immune system, inflammation, Nanomedicina, Nanoparticles, nanoparticles, DISCIPLINES AND OCCUPATIONS::Natural Science Disciplines::Nanotechnology::Nanomedicine, 0210 nano-technology, Tolerance

File Description: application/pdf

Access URL: https://www.mdpi.com/2079-4991/11/11/2991/pdf
https://pubmed.ncbi.nlm.nih.gov/34835755
http://hdl.handle.net/10261/266073
https://hdl.handle.net/11351/7215
https://doaj.org/article/874cf5a160a341b7a51e1de748c2940f
https://www.mdpi.com/2079-4991/11/11/2991/pdf
https://www.mdpi.com/2079-4991/11/11/2991
https://hdl.handle.net/20.500.14243/452064
http://www.scopus.com/record/display.url?eid=2-s2.0-85118479040&origin=inward
https://doi.org/10.3390/nano11112991
https://ddd.uab.cat/record/268419