Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab

Authors: Alberto Hernando-Calvo, S.Y. Cindy Yang, Maria Vila-Casadesús, Ming Han, Zhihui Amy Liu, A Hal K. Berman, Anna Spreafico, Albiruni Abdul Razak, Stephanie Lheureux, Aaron R. Hansen, Deborah Lo Giacco, Farnoosh Abbas-Aghababazadeh, Judith Matito, Benjamin Haibe-Kains, Trevor J. Pugh, Scott V. Bratman, Alexey Aleshin, Roger Berche, Omar Saavedra, Elena Garralda, Sawako Elston, Lillian L. Siu, Pamela S. Ohashi, Ana Vivancos, Philippe L. Bedard

Contributors: Institut Català de la Salut, [Hernando-Calvo A] Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. Departamento de Medicina, Universidad Autonoma de Barcelona (UAB), Bellaterra, Spain. [Yang SYC, Han M, Liu ZA, Berman AHK] Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. [Vila-Casadesús M, Lo Giacco D, Matito J, Berche R, Saavedra O, Garralda E, Vivancos A] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

Source: JCO Precis Oncol
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Subject Terms: Male, Adult, 0301 basic medicine, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal::Antibodies, Monoclonal, Humanized, Other subheadings::Other subheadings::/therapeutic use, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, Otros calificadores::Otros calificadores::/uso terapéutico, Medicaments antineoplàstics - Ús terapèutic, PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Phenomena::Genetic Structures::Transcriptome, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales::anticuerpos monoclonales humanizados, Antibodies, Monoclonal, Humanized, Transcriptomes, Circulating Tumor DNA, DISEASES::Neoplasms, 03 medical and health sciences, Antineoplastic Agents, Immunological, COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos::inmunoterapia antineoplásica, Neoplasms, CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Antineoplastic Agents, Immunological, Original Reports, Biomarkers, Tumor, COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ácidos nucleicos libres de células::ADN tumoral circulante, Humans, Aged, 0303 health sciences, Other subheadings::Other subheadings::Other subheadings::/drug therapy, Anticossos monoclonals - Ús terapèutic, Càncer - Tractament, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome, Middle Aged, CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::Cell-Free Nucleic Acids::Circulating Tumor DNA, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento, Treatment Outcome, ENFERMEDADES::neoplasias, FENÓMENOS Y PROCESOS::fenómenos genéticos::fenómenos genéticos::estructuras genéticas::transcriptoma, Avaluació de resultats (Assistència sanitària), Female, Transcriptome

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39178369
https://hdl.handle.net/11351/12597
https://ddd.uab.cat/record/303226

Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution

Authors: Casanova-Salas, Irene, Aguilar, Daniel, Cordoba, Sarai, Agundez, Laura, Brandariz, Julian, Herranz Martín, Nicolás, Mas Malavila, Alba, Soriano-Navarro, Mario, Mir, Gisela, Castellano-Sanz, Elena, Mast, Richard, Gonzalez Amaya, Lucila, del Mar Suanes, Maria, Nonell Malezon, Lara, de Albert de Delás-Vigo, Matias, Peinado, Hector, Santamaria Margalef, Anna, Hernandez-Losa, Javier, Mateo, Joaquin, Castro, Natalia, Celma, Ana, Simonetti, Sara, Cresta Morgado, Pablo, Morales-Barrera, Rafael, Macarena, Gonzalez, SIERRA, ALEXANDRE, Carles, Joan

Contributors: Institut Català de la Salut, Casanova-Salas I, Aguilar D, Cordoba-Terreros S, Agundez L, Brandariz J, Mas A, Cresta P, Mir G, Simonetti S, Delgado-Serrano L, Gonzalez L, Castro N, Nonell L Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Herranz N Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Gonzalez M, Morales-Barrera R, Sierra A, del Mar Suanes M, Carles J, Mateo J Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Mast R, de Albert M Vall d’Hebron Hospital Universitari, Barcelona, Spain. Celma A, Santamaria A, Hernández-Losa J Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus

Source: Scientia

Subject Terms: Pròstata - Càncer - Aspectes genètics, Transcriptomes, Pròstata - Biòpsia, DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms, PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Phenomena::Genetic Structures::Transcriptome, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Liquid Biopsy, ANATOMY::Cells::Cellular Structures::Extracellular Space::Extracellular Vesicles, ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata, FENÓMENOS Y PROCESOS::fenómenos genéticos::fenómenos genéticos::estructuras genéticas::transcriptoma, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia líquida, ANATOMÍA::células::estructuras celulares::espacio extracelular::vesículas extracelulares

File Description: application/pdf

Relation: Cancer Cell;42(7); https://doi.org/10.1016/j.ccell.2024.06.003; info:eu-repo/grantAgreement/EC/H2020/847648; https://hdl.handle.net/11351/11705

Availability: https://hdl.handle.net/11351/11705
https://doi.org/10.1016/j.ccell.2024.06.003

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Authors: Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeón-Aznar, José Luis Callejas, Shervin Assassi, P. Carreira, I. Castellvi, R. Ríos, R. García Portales, A. Fernández-Nebro, F. J. García-Hernández, M. A. Aguirre, B. Fernández-Gutiérrez, L. Rodríguez-Rodríguez, P. García de la Peña, E. Vicente, J. L. Andreu, M. Fernández de Castro, F. J. López-Longo, V. Fonollosa, A. Guillén, G. Espinosa, C. Tolosa, A. Pros, E. Beltrán, M. Rodríguez Carballeira, F. J. Narváez, M. Rubio Rivas, V. Ortiz-Santamaría, A. B. Madroñero, M. A. González-Gay, B. Díaz, L. Trapiella, M. V. Egurbide, P. Fanlo-Mateo, L. Saez-Comet, F. Díaz, J. A. Roman-Ivorra, J. J. Alegre Sancho, M. Freire, F. J. Blanco Garcia, N. Oreiro, T. Witte, A. Kreuter, G. Riemekasten, P. Airò, C. Magro, A. E. Voskuyl, M. C. Vonk, R. Hesselstrand, A. Nordin, C. Lunardi, A. Gabrielli, A. Hoffmann-Vold, J. H. W. Distler, L. Padyukov, B. P. C. Koeleman, Susanna M. Proudman, Mandana Nikpour, W. Stevens, J. Zochling, J. Sahhar, J. Roddy, P. Nash, K. Tymms, M. Rischmueller, S. Lester, Barbara Vigone, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux, Anne-Lise Maudoux, Carlos Vasconcelos, Ana Tavares, Esmeralda Neves, Raquel Faria, Mariana Brandão, Ana Campar, António Marinho, Fátima Farinha, Isabel Almeida, Miguel Angel Gonzalez-Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ricard Cervera, Ignasi Rodríguez-Pintó, Gerard Espinosa, Rik Lories, Ellen De Langhe, Doreen Belz, Torsten Witte, Niklas Baerlecken, Georg Stummvoll, Michael Zauner, Michaela Lehner, Eduardo Collantes, Rafaela Ortega-Castro, Ma Angeles Aguirre-Zamorano, Alejandro Escudero-Contreras, Ma Carmen Castro-Villegas, María Concepción Fernández Roldán, Norberto Ortego, Enrique Raya, Inmaculada Jiménez Moleón, Enrique de Ramon, Isabel Díaz Quintero, Pier Luigi Meroni, Maria Gerosa, Tommaso Schioppo, Carolina Artusi, Carlo Chizzolini, Aleksandra Zuber, Donatienne Wynar, Laszló Kovács, Attila Balog, Magdolna Deák, Márta Bocskai, Sonja Dulic, Gabriella Kádár, Falk Hiepe, Velia Gerl, Silvia Thiel, Manuel Rodriguez Maresca, Antonio López-Berrio, Rocío Aguilar-Quesada, Héctor Navarro-Linares, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcón-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin

Contributors: Institut Català de la Salut, [Kerick M] Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain. [Acosta-Herrera M] Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain. Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs. GRANADA, Granada, Spain. [Simeón-Aznar CP] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Callejas JL] Department of Internal Medicine, Hospital San Cecilio, Granada, Spain. [Assassi S] Department of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, USA, Vall d'Hebron Barcelona Hospital Campus, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie

Source: NPJ Genom Med
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Digibug. Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-12 (2022)
International SSc Group, Australian Scleroderma Interest Group (ASIG) & PRECISESADS Clinical Consortium 2022, 'Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis', NPJ GENOMIC MEDICINE, vol. 7, no. 1, 57. https://doi.org/10.1038/s41525-022-00327-8
NPJ Genomic Medicine, 7, 1
NPJ genomic medicine, Vol. 7, no.1, p. 57 [1-12] (2022)

Subject Terms: Genetic Processes, FENÓMENOS Y PROCESOS::fenómenos genéticos::expresión génica, 0301 basic medicine, RP-C4-CYP21-TNX RCCX MODULES, Medical Sciences, Other subheadings::Other subheadings::Other subheadings::/genetics, AUTOIMMUNITY, Immunology, Medical biotechnology, PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Phenomena::Genetic Structures::Transcriptome, COPY-NUMBER VARIATION, VARIANTS, SUSCEPTIBILITY, QH426-470, Quantitative trait, DISEASE, CLASSIFICATION, Article, Biomedical Informatics, 03 medical and health sciences, Otros calificadores::Otros calificadores::Otros calificadores::/genética, Medical Specialties, Medicine and Health Sciences, Genetics, DISEASES::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Scleroderma, Systemic, 03.02. Klinikai orvostan, Esclerosi sistemàtica progressiva - Aspectes genètics, Genetic association study, Genetics & Heredity, RISK, 0303 health sciences, Science & Technology, Expressió gènica, 3. Good health, RECEPTORS, Rheumatology - Radboud University Medical Center, Systemic sclerosis, Radboudumc 5: Inflammatory diseases RIHS: Radboud Institute for Health Sciences, Medicine, Structural variation, HEALTH, ENFERMEDADES::enfermedades de la piel y tejido conjuntivo::enfermedades del tejido conjuntivo::esclerodermia sistémica, Genetic Phenomena, Medical Genetics, Life Sciences & Biomedicine

File Description: application/pdf; text

Access URL: https://pubmed.ncbi.nlm.nih.gov/36198672
https://hdl.handle.net/11351/8494
https://hdl.handle.net/20.500.12530/96431
http://hdl.handle.net/10668/19554
https://doaj.org/article/bc1f849f269a49ad8114bddf64958fc9
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/287598
https://research.manchester.ac.uk/en/publications/51292197-2981-466a-98eb-11d2ae071ab2
https://research.vumc.nl/en/publications/607024cb-ceb7-46e9-9e44-376975965512
https://pure.amsterdamumc.nl/en/publications/ea5ed0e3-4942-4622-8b8a-4ded3b991fe0
https://doi.org/10.1038/s41525-022-00327-8
https://repository.ubn.ru.nl//bitstream/handle/2066/287598/287598.pdf
https://hdl.handle.net/2066/287598
https://hdl.handle.net/2078.1/277433
https://hdl.handle.net/10481/77756
https://hdl.handle.net/10668/19554
https://discovery-pp.ucl.ac.uk/id/eprint/10157681/