Association between the degree of immunosuppression measured by nuclear factor of activated T- cells regulated genes and cytomegalovirus infection in lung transplant recipients

Authors: Boada Pérez, Meritxell

Thesis Advisors: Monforte Torres, Victor, Gómez Olles, Susana, Cortés Hernández, Josefina

Source: TDX (Tesis Doctorals en Xarxa)

Subject Terms: Trasplantament pulmonar, Lung transplantation, Trasplante pulmonar, Farmacodinàmica, Pharmacodynamics, Farmacodinámica, Citomegalovirus, Cytomegalovirus, Ciències de la Salut

Time: 616.2

File Description: application/pdf

Access URL: http://hdl.handle.net/10803/694101

Resilience and Bifurcations in Viral Infection Models with Drug Resistance and Time-Varying Dynamics.

Authors: Guo, Wenlong¹ (AUTHOR) renjianxinghai@qq.com, Wang, Shaoli² (AUTHOR) wslheda@163.com, Rong, Libin³ (AUTHOR) libinrong@ufl.edu

Source: SIAM Journal on Applied Dynamical Systems. 2025, Vol. 24 Issue 4, p2916-2949. 34p.

Subject Terms: *MATHEMATICAL models, DRUG resistance, PHARMACODYNAMICS, VIRUS diseases, NONLINEAR mechanics, THERAPEUTICS, ECOLOGICAL resilience, BIFURCATION theory

Physics-Informed Neural Networks for Pharmacodynamic Compartment Models of Animal Cell Culture

Authors: Liu, Yang, Zhang, Yichen, Liu, Jiaqi, Ma, Zhiqiang

Source: 2025 19th International Conference on Complex Medical Engineering (CME) Complex Medical Engineering (CME), 2025 19th International Conference on. :135-138 Aug, 2025

Relation: 2025 19th International Conference on Complex Medical Engineering (CME)

Nonlinear dynamics in pulse-modulated feedback drug dosing*

Authors: Medvedev, Alexander, Proskurnikov, Anton V., Zhusubaliyev, Zhanybai T.

Source: 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) Engineering in Medicine and Biology Society (EMBC), 2025 47th Annual International Conference of the IEEE. :1-7 Jul, 2025

Relation: 2025 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Glutamine Potentiates Cefoperazone-Sulbactam Activity against Acinetobacter baumannii by Increasing Drug Uptake and ROS

Authors: Wang, Shi-wen^aff1, Shi, Zheng-qi^aff2, Zhu, Jia-xin^aff3, Xiang, Jiao^aff3, Chen, Yue-tao^aff1, Li, Shao-hua^aff1, Zhao, Xian-liang^aff4, Zeng, Ying-yue^aff1, Tao, Yuan^aff1, Fu, Huan-zhe^aff1, Lin, Hui-yin^aff1, Tang, Jin^aff5, Huang, Xiao-xia^aff5, Wang, Xin^aff5, Peng, Xuan-xian^aff1, Wu, Kui-hai^aff2, Zhang, Tian-tuo^aff3, Li, Hui^aff1

Source: ACS Infectious Diseases. 11(11):3222-3236

Availability: https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00616

Pharmacokinetics and pharmacodynamics of oral insulin (ORMD‐0801) in healthy subjects: A phase I study using hyperinsulinaemic‐euglycaemic clamp.

Authors: Chen, Yufei^1,2 (AUTHOR), Hu, Zhuomeng^1,2 (AUTHOR), Zhang, Yifei^1,2 (AUTHOR), Ma, Ming³ (AUTHOR), Lv, Qing^1,2 (AUTHOR), Zhou, Jie^1,2 (AUTHOR), Wang, Jiayi^1,2 (AUTHOR), Shao, Ting^1,2 (AUTHOR), Shi, Jia^1,2 (AUTHOR), Zhou, Yingxia^1,2 (AUTHOR), Lu, Jiangjie³ (AUTHOR), Sheng, Haiyuan³ (AUTHOR), Gao, Ya³ (AUTHOR), Ning, Guang^1,2 (AUTHOR) gning@sibs.ac.cn, Wang, Weiqing^1,2 (AUTHOR) wqingw@shsmu.edu.cn

Source: Diabetes, Obesity & Metabolism. Dec2025, Vol. 27 Issue 12, p6905-6913. 9p.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *CLINICAL trials, *INSULIN therapy, *HUMAN experimentation, *INSULIN, *GLUCOSE clamp technique

Safety and pharmacodynamics of the ferroportin inhibitor vamifeport in patients with non-transfusion-dependent β-thalassemia: results from a randomized phase 2a study.

Authors: Kattamis, Antonis¹ (AUTHOR) ankatt@med.uoa.gr, Taher, Ali² (AUTHOR) ataher@aub.edu.lb, Viprakasit, Vip³ (AUTHOR) vip.vip@mahidol.edu, Levin, Carina^4,5 (AUTHOR) levin_c@clalit.org.il, Hermosilla, Ricardo⁶ (AUTHOR) ricardo.hermosilla.external@viforpharma.com, Szecsödy, Peter⁷ (AUTHOR) peter.szecsoedy@viforpharma.com, Richard, Frank^7,8 (AUTHOR) frank.richard@hdpharma.com, Cappellini, M. Domenica⁹ (AUTHOR) maria.cappellini@unimi.it, Porter, John¹⁰ (AUTHOR) j.porter@ucl.ac.uk

Source: Orphanet Journal of Rare Diseases. 11/25/2025, Vol. 20 Issue 1, p1-16. 16p.

Subject Terms: *SAFETY, *PHARMACODYNAMICS, *IRON chelates, *IRON overload, *ERYTHROPOIESIS, *BETA-Thalassemia, *IRON metabolism, *CLINICAL trials

Evaluation of the PK/PD Changes on MASLD‐Related Population—An Example From Simultaneous Acetaminophen Parent‐Metabolite PBPK/PD Modeling.

Authors: Zhao, Shanshan¹ (AUTHOR) dorvs@163.com, Zhang, Lan¹ (AUTHOR) dorvs@163.com

Source: CPT: Pharmacometrics & Systems Pharmacology. Nov2025, p1. 16p. 5 Illustrations.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *ACETAMINOPHEN, *NON-alcoholic fatty liver disease, *INDIVIDUALIZED medicine, *METABOLITES, *DRUG development

Neural Controlled Differential Equation and Its Application in Pharmacokinetics and Pharmacodynamics.

Authors: Wu, Zhisong¹ (AUTHOR), Luo, Pingyao¹ (AUTHOR), Chen, Rong¹ (AUTHOR), Liu, Yaou^1,2 (AUTHOR), Jian, Weizhe¹ (AUTHOR), Zhou, Tianyan¹ (AUTHOR) tianyanzhou@bjmu.edu.cn

Source: CPT: Pharmacometrics & Systems Pharmacology. Nov2025, p1. 11p. 7 Illustrations.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *PREDICTION models, *REPLICATION (Experimental design), *MACHINE learning, *OPTIMIZERS (Computer software), *PARAMETERIZATION

Does the Injection Site Matter During CPR? A Systematic Review and Meta-Analysis of Drug Pharmacokinetics and Pharmacodynamics.

Authors: Zagalioti, Sofia-Chrysovalantou¹ (AUTHOR), Gkarmiri, Sofia^1,2 (AUTHOR), Karagiannidis, Efstratios^1,3 (AUTHOR), Stachteas, Panagiotis^2,4 (AUTHOR), Zgouridou, Aikaterini^1,5 (AUTHOR), Zagaliotis, Panagiotis^3,6 (AUTHOR), Kotzampassi, Katerina^4,7 (AUTHOR), Grosomanidis, Vasileios^1,5 (AUTHOR), Raikos, Nikolaos^2,6 (AUTHOR), Aggou, Maria^3,7 (AUTHOR), Fragakis, Nikolaos^2,4 (AUTHOR), Fyntanidou, Barbara^1,5 (AUTHOR)

Source: Journal of Clinical Medicine. Nov2025, Vol. 14 Issue 21, p7497. 17p.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *CARDIOPULMONARY resuscitation, *INTRAVENOUS therapy, *CARDIAC arrest, *DRUG delivery systems

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Efbemalenograstim Alfa (F-627), a Novel Long-Acting rhG-CSF, in Healthy Chinese Participants: An Open-Label, Single-Center Phase I Study.

Authors: Cao, Zhihai^1,2 (AUTHOR), Li, Yao^1,2 (AUTHOR), Hou, Denny³ (AUTHOR), Wang, Shufang³ (AUTHOR), Yao, Wei³ (AUTHOR), Zhang, Gaochong³ (AUTHOR), Chen, Jianmin³ (AUTHOR), Tang, Zhengwei³ (AUTHOR), Song, Linda³ (AUTHOR), Zhao, Xingna³ (AUTHOR), Chu, Xiaoxiang³ (AUTHOR), Wang, Xiaoyan³ (AUTHOR), Li, Renshu³ (AUTHOR), Hu, Wei^1,2 (AUTHOR) huwei@ahmu.edu.cn

Source: Clinical Drug Investigation. Nov2025, Vol. 45 Issue 11, p855-863. 9p.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *GRANULOCYTE-colony stimulating factor, *SAFETY, *HUMAN research subjects, *QUANTITATIVE research

A phase 2, proof-of-concept, placebo-controlled, randomized, multicenter, double-blind study to evaluate the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of Usnoflast (ZYIL1) in patients with amyotrophic lateral sclerosis.

Authors: Yeole, Amit¹ (AUTHOR), Khanna, Laxmi² (AUTHOR), Doshi, Maulik³ (AUTHOR) maulik.doshi@zyduslife.com, Sharma, Arvind⁴ (AUTHOR), Uttarwar, Pratik⁵ (AUTHOR), Doshi, Suyog⁶ (AUTHOR), Kaushik Kumar, Rana⁷ (AUTHOR), Venkataramana, N.⁸ (AUTHOR), Parmar, Deven⁹ (AUTHOR)

Source: Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Nov2025, Vol. 26 Issue 7/8, p794-801. 8p.

Subject Terms: *AMYOTROPHIC lateral sclerosis, *PHARMACODYNAMICS, *CLINICAL trials, *SPINAL muscular atrophy, *PHARMACOKINETICS, *SAFETY, *TREATMENT effectiveness, *THERAPEUTICS

Probability of pharmacokinetic/pharmacodynamic target attainment for different piperacillin/tazobactam dosing regimens in renally impaired patients in a non‐intensive care unit setting.

Authors: Dohmann, Emma¹ (AUTHOR), Hagel, Stefan² (AUTHOR), Kurlbaum, Max^3,4 (AUTHOR), Schellong, Paul² (AUTHOR), Scherf‐Clavel, Oliver⁵ (AUTHOR), Surat, Güzin⁶ (AUTHOR) surat_g@ukw.de

Source: British Journal of Clinical Pharmacology. Nov2025, Vol. 91 Issue 11, p3070-3081. 12p.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *HOSPITAL patients, *BETA-lactamase inhibitors, *PSEUDOMONAS aeruginosa, *DRUG therapy, *KIDNEY diseases

Pharmacokinetic and pharmacodynamic modelling of continuous erythropoiesis receptor activator in children: A comprehensive analysis and real‐world data validation.

Authors: Mouksassi, Samer¹ (AUTHOR), Schaefer, Franz² (AUTHOR), Warady, Bradley A.³ (AUTHOR), Schmitt, Claus P.² (AUTHOR), Reigner, Sylvie Meyer⁴ (AUTHOR), Studer, Milena⁴ (AUTHOR), Chanu, Pascal⁵ (AUTHOR), Frey, Nicolas⁶ (AUTHOR) nicolas.frey@roche.com

Source: British Journal of Clinical Pharmacology. Nov2025, Vol. 91 Issue 11, p3189-3200. 12p.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *MINORS, *RECOMBINANT erythropoietin, *HEMODIALYSIS, *EMPIRICAL research, *CLINICAL trials, *CHRONIC kidney failure

Comparative Pharmacodynamic Bioequivalence Study of Enoxaparin Sodium 100 mg/1 mL Solution for Injection in Prefilled Syringe in Healthy Volunteers Under Fasting Conditions.

Authors: Talukdar, Naba Kumar¹ (AUTHOR) naba.talukdar@accutestglobal.com, Sonar, Shailesh² (AUTHOR), Pal, Nisha¹ (AUTHOR), Silva, Uilberson³ (AUTHOR)

Source: Clinical Pharmacology in Drug Development. Nov2025, Vol. 14 Issue 11, p821-828. 8p.

Subject Terms: *ENOXAPARIN, *PHARMACODYNAMICS, *VOLUNTEERS, *CLINICAL trials, *DRUG interactions, *SYRINGES, *ANTITHROMBIN III, *BLOOD coagulation factor X

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects.

Authors: Lee, Sooyoun¹ (AUTHOR), Kim, Hyun Chul¹ (AUTHOR), Yoon, Young Ran^2,3 (AUTHOR), Jang, In‐Jin¹ (AUTHOR), Yoo, Sang‐Ku⁴ (AUTHOR), Yu, Kyung‐Sang¹ (AUTHOR) ksyu@snu.ac.kr

Source: British Journal of Clinical Pharmacology. Oct2025, p1. 9p. 3 Illustrations.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *ORAL drug administration, *ANTIOBESITY agents, *CONTROL groups, *SAFETY, *CLINICAL trials, *OBESITY

Pharmacodynamics of Vancomycin Against Coagulase‐Negative Staphylococci Bloodstream Infections.

Authors: Harwood, Kiera H.^1,2 (AUTHOR), Brusamarello, Courtney E.^1,3 (AUTHOR), Wilkins, Amanda L.^1,2,3 (AUTHOR), Zhu, Xiao⁴ (AUTHOR), Landersdorfer, Cornelia B.⁵ (AUTHOR), Gwee, Amanda^1,2,3 (AUTHOR) amanda.gwee@rch.org.au

Source: Pharmacology Research & Perspectives. Oct2025, Vol. 13 Issue 5, p1-6. 6p.

Subject Terms: *VANCOMYCIN, *PHARMACODYNAMICS, *ANTIBIOTICS, *STAPHYLOCOCCUS epidermidis, *BLOODBORNE infections, *TREATMENT effectiveness

Pharmacokinetics, pharmacodynamics and safety profile of SKB336, a selective inhibitor of coagulation factor XI/XIa in healthy subjects.

Authors: Xiang, Qian¹ (AUTHOR) xiangqz@pkufh.com, Liu, Zhiyan¹ (AUTHOR), Xie, Qiufen² (AUTHOR), Zhao, Nan² (AUTHOR), Zhou, Shuang³ (AUTHOR), Cao, Linyu¹ (AUTHOR), Zhao, Xia² (AUTHOR), Li, Yaling⁴ (AUTHOR), Si, Jing⁴ (AUTHOR), Wu, Qingmei⁴ (AUTHOR), Ge, Junyou^4,5 (AUTHOR), Cui, Yimin¹ (AUTHOR) cui.pharm@pkufh.com

Source: British Journal of Clinical Pharmacology. Oct2025, Vol. 91 Issue 10, p2817-2826. 10p.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *ANTICOAGULANTS, *HUMAN experimentation, *BLOOD coagulation factor X, *DOSE-effect relationship in pharmacology, *SAFETY

Deciphering the Pharmacodynamic Basis of Biyan Qingdu Granules: Integrated key Pharmacodynamic Components Identification, Multi‐Tissue Distribution, and Metabolic Profiling.

Authors: Zhang, Na¹ (AUTHOR), Fan, Xiang² (AUTHOR), Lv, Fengyi³ (AUTHOR), Li, Peng⁴ (AUTHOR), Xu, Guanghui⁵ (AUTHOR) 1312828965@qq.com, Zhao, Min¹ (AUTHOR) zm19871224@sina.com

Source: Journal of Mass Spectrometry. Oct2025, Vol. 60 Issue 10, p1-15. 15p.

Subject Terms: *PHARMACODYNAMICS, *CHINESE medicine, *PHARMACOKINETICS, *METABOLITES, *METABOLIC profile tests, *PHARMACOLOGY, *BIOACTIVE compounds

Pharmacokinetics and Penetration of a Novel Pharmacodynamically Optimized, Carbapenem-Sparing Antibiotic, WCK 4282 (Cefepime/Tazobactam), into Epithelial Lining Fluid of Healthy, Lung-, and Thigh-Infected Neutropenic Mice.

Authors: Chavan, Rajesh¹ (AUTHOR) rchavan@wockhardt.com, Zope, Vineet¹ (AUTHOR), Patil, Kiran¹ (AUTHOR), Takalkar, Swapna¹ (AUTHOR), Tayde, Pavan¹ (AUTHOR), Umarkar, Kushal¹ (AUTHOR), Yeole, Ravindra¹ (AUTHOR), Bhagwat, Sachin¹ (AUTHOR)

Source: Microbial Drug Resistance: Mechanism, Epidemiology, & Disease. Oct2025, Vol. 31 Issue 10, p338-344. 7p.

Subject Terms: *PHARMACOKINETICS, *PHARMACODYNAMICS, *CEFEPIME, *TAZOBACTAM, *ANIMAL models in research, *ANTIBIOTICS, *BODY fluids, *ANIMAL disease models