The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

Συγγραφείς: Joan Kyula-Currie, Victoria Roulstone, James Wright, Francesca Butera, Arnaud Legrand, Richard Elliott, Martin McLaughlin, Galabina Bozhanova, Dragomir Krastev, Stephen Pettitt, Tencho Tenev, Magnus Dillon, Shane Foo, Emmanuel C. Patin, Victoria Jennings, Charleen Chan Wah Hak, Elizabeth Appleton, Amarin Wongariyapak, Malin Pedersen, Antonio Rullan, Jyoti Choudhary, Chris Bakal, Pascal Meier, Christopher J. Lord, Alan Melcher, Kevin J. Harrington

Πηγή: Nat Commun

Θεματικοί όροι: Poly (ADP-Ribose) Polymerase-1/metabolism, Poly (ADP-Ribose) Polymerase-1, Apoptosis, Poly(ADP-ribose) Polymerase Inhibitors, Reoviridae, Article, Cell Line, Mice, DEAD Box Protein 58/metabolism, Cell Line, Tumor, Neoplasms, Neoplasms/therapy, Animals, Humans, Oncolytic Virotherapy, Tumor, Animal, Apoptosis/drug effects, NF-kappa B, Drug Synergism, Poly(ADP-ribose) Polymerase Inhibitors/pharmacology, Disease Models, Animal, Oncolytic Viruses, Oncolytic Virotherapy/methods, Disease Models, NF-kappa B/metabolism, Phthalazines, DEAD Box Protein 58, Female, Phthalazines/pharmacology

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40628717
https://eprints.whiterose.ac.uk/id/eprint/230921/

Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles

Συγγραφείς: Bhatt, Darshak K, Boerma, Annemarie, Bustos, Silvina Odete, Otake, Andréia Hanada, Murillo Carrasco, Alexis Germán, Reis, Patrícia Pintor, Chammas, Roger, Daemen, Toos, Andrade, Luciana Nogueira de Sousa

Πηγή: Sci Rep
Scientific Reports, Vol 15, Iss 1, Pp 1-15 (2025)

Θεματικοί όροι: Oncolytic virus, Immunomodulatory, Science, Alphavirus/physiology, Alphavirus, Article, Cell Line, Extracellular Vesicles, Mice, Cell Line, Tumor, Tumor Microenvironment, Tumor Microenvironment/immunology, Humans, Animals, Oncolytic Viruses/physiology, Melanoma, Cell Proliferation, Oncolytic Virotherapy, Tumor, Extracellular Vesicles/metabolism, Extracellular vesicles, Semliki forest virus, Melanoma/therapy, MicroRNAs/genetics, Oncolytic Viruses, MicroRNAs, Oncolytic Virotherapy/methods, Semliki forest virus/physiology, Medicine

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39755711
https://doaj.org/article/77b3aee7bd0043dc910d82b05e2f6d07

Oncolytic virus and tumor-associated macrophage interactions in cancer immunotherapy

Συγγραφείς: Lecoultre, Marc, Walker, Paul Richard, El Helali, Aya

Πηγή: Clin Exp Med

Θεματικοί όροι: Oncolytic Virotherapy, 0301 basic medicine, Neoplasms / therapy, Neoplasms / immunology, Tumor-Associated Macrophages / immunology, Review, Oncolytic Viruses, 03 medical and health sciences, 0302 clinical medicine, Immunotherapy / methods, Oncolytic Viruses / immunology, Oncolytic Viruses / genetics, Neoplasms, Tumor-Associated Macrophages, Humans, Animals, Immunotherapy, Oncolytic Virotherapy / methods

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39196415
https://archive-ouverte.unige.ch/unige:179951
https://doi.org/10.1007/s10238-024-01443-8

The OV-KillSwitch Expansion Pack: Nutrigenetic, Microbiome, Frequency, and Enzyme-Driven Precision Oncology

Συγγραφείς: Mohamed, Anwar

Θεματικοί όροι: Nutritional Sciences/trends, Nutritional Sciences, Psycho-Oncology, Immunology, Biophysics, Immune Recalibration, Quantum Biology, Medical Oncology, Metabolic Reprogramming/immunology, Nutritional Science, Neurobiology, Virology, Ferroptosis, Integrative Oncology, Oncolytic Virotherapy/trends, Computational Biology/classification, Oncolytic Virotherapy, Functional Medicine, Metabolic Reprogramming, AI-Driven Oncology, Metabolic Reprogramming/genetics, FOS: Clinical medicine, Systems Biology, Computational Biology, Systems Biology/trends, Immunologic Surveillance/immunology, PCD, Receptors, Immunologic/immunology, Neurobiology/trends, Biophysics/trends, OV Optimization, Oncolytic Virotherapy/methods, Oncology, Computational Biology/trends, Immunologic Memory/immunology, Biophysics/education, Computational Biology/ethics, Computational Biology/standards, Ferroptosis/immunology

Effects of virus-induced immunogenic cues on oncolytic virotherapy

Συγγραφείς: Bhatt, Darshak K., Janzen, Thijs, Daemen, Toos, Weissing, Franz J.

Πηγή: Sci Rep
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Θεματικοί όροι: Oncolytic Virotherapy, 0301 basic medicine, 0303 health sciences, Oncolytic Viruses/immunology, Science, Stochastic outcome, Article, Spatial model, Oncolytic Viruses, 03 medical and health sciences, Oncolytic Virotherapy/methods, Therapy failure, Neoplasms, Neoplasms/therapy, Medicine, Humans, Immunogenic molecules, Immune response

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39572761
https://doaj.org/article/90f25be7f56c4b8ba90a99bb68061cce
https://research.rug.nl/en/publications/b51d252f-0719-4538-b249-075d8d7a5781
https://hdl.handle.net/11370/b51d252f-0719-4538-b249-075d8d7a5781
https://doi.org/10.1038/s41598-024-80542-8

Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients

Συγγραφείς: Adel Samson, Emma J. West, Jonathan Carmichael, Karen J. Scott, Samantha Turnbull, Bethany Kuszlewicz, Rajiv V. Dave, Adam Peckham-Cooper, Emma Tidswell, Jennifer Kingston, Michelle Johnpulle, Barbara da Silva, Victoria A. Jennings, Kaidre Bendjama, Nicolas Stojkowitz, Monika Lusky, K.R. Prasad, Giles J. Toogood, Rebecca Auer, John Bell, Chris J. Twelves, Kevin J. Harrington, Richard G. Vile, Hardev Pandha, Fiona Errington-Mais, Christy Ralph, Darren J. Newton, Alan Anthoney, Alan A. Melcher, Fiona Collinson

Συνεισφορές: Harrington, Kevin, Melcher, Alan

Πηγή: Cancer Immunol Res

Θεματικοί όροι: Oncolytic Virotherapy, 0301 basic medicine, 0303 health sciences, Oncolytic Viruses - genetics, Liver Neoplasms, Vaccinia virus, Neoadjuvant Therapy, 3. Good health, Oncolytic Viruses, 03 medical and health sciences, Oncolytic Virotherapy - methods, Vaccinia virus - genetics, Leukocytes, Mononuclear, Humans, Liver Neoplasms - therapy, Research Articles

Περιγραφή αρχείου: Print-Electronic; application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35439304
https://openresearch.surrey.ac.uk/esploro/outputs/journalArticle/Neoadjuvant-Intravenous-Oncolytic-Vaccinia-Virus-Therapy/99828351302346
https://doi.org/10.1158/2326-6066.CIR-21-0171
https://eprints.whiterose.ac.uk/id/eprint/200646/

Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

Συγγραφείς: Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Rozanne Arulanandam, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier

Πηγή: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Kurmasheva, N, Said, A, Wong, B, Kinderman, P, Han, X, Rahimic, A H F, Kress, A, Carter-Timofte, M E, Holm, E, van der Horst, D, Kollmann, C F, Liu, Z, Wang, C, Hoang, H-D, Kovalenko, E, Chrysopoulou, M, Twayana, K S, Ottosen, R N, Svenningsen, E B, Begnini, F, Kiib, A E, Kromm, F E H, Weiss, H J, Di Carlo, D, Muscolini, M, Higgins, M, van der Heijden, M, Bardoul, A, Tong, T, Ozsvar, A, Hou, W-H, Schack, V R, Holm, C K, Zheng, Y, Ruzek, M, Kalucka, J, de la Vega, L, Elgaher, W A M, Korshoej, A R, Lin, R, Hiscott, J, Poulsen, T, O'Neill, L A, Roy, D G, Rinschen, M M, van Montfoort, N, Diallo, J-S, Farin, H F, Alain, T & Olagnier, D 2024, 'Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways', Nature Communications, vol. 15, no. 1, 4096. https://doi.org/10.1038/s41467-024-48422-x
Nature Communications

Θεματικοί όροι: 0301 basic medicine, NF-E2-Related Factor 2, Science, Antiviral Agents/pharmacology, Antiviral Agents, Article, Vesicular stomatitis Indiana virus, Cell Line, Mice, 03 medical and health sciences, NF-E2-Related Factor 2/metabolism, Inflammation/drug therapy, Signal Transduction/drug effects, Cell Line, Tumor, name=General Biochemistry,Genetics and Molecular Biology, Vesicular stomatitis Indiana virus/physiology, Animals, Humans, Succinates/pharmacology, Colonic Neoplasms/therapy, Oncolytic Virotherapy, Inflammation, 0303 health sciences, Tumor, Kelch-Like ECH-Associated Protein 1, I-kappa B Kinase/metabolism, NF-kappa B, Succinates, Kelch-Like ECH-Associated Protein 1/metabolism, I-kappa B Kinase, 3. Good health, Oncolytic Viruses, Oncolytic Virotherapy/methods, name=General Physics and Astronomy, Interferon Type I/metabolism, NF-kappa B/metabolism, Interferon Type I, Colonic Neoplasms, Female, name=General Chemistry, Signal Transduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38750019
https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99
https://hdl.handle.net/1887/4107583
https://www.scopus.com/pages/publications/85193395304
https://doi.org/10.1038/s41467-024-48422-x
https://pure.au.dk/portal/en/publications/be468023-099c-4309-a385-972e7c784cb7

Targeting Biophysical Cues: a Niche Approach to Study, Diagnose, and Treat Cancer.

Συγγραφείς: Zhang, Shirley X, Liu, Linan, Zhao, Weian

Πηγή: Trends in cancer. 4(4)

Θεματικοί όροι: Antineoplastic Agents: pharmacology, therapeutic use, Biomarkers, Tumor: analysis, Biophysics: methods, trends, Elasticity Imaging Techniques, Extracellular Matrix: drug effects, pathology, Humans, Medical Oncology: methods, trends, Neoplasms: diagnosis, etiology, pathology, therapy, Oncolytic Virotherapy: methods, trends, Treatment Outcome, Tumor Microenvironment: drug effects

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/9ph190fk
https://escholarship.org/content/qt9ph190fk/qt9ph190fk.pdf

Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy

Συγγραφείς: Timothy Kottke, Jason Tonne, Laura Evgin, Christopher B. Driscoll, Jacob van Vloten, Victoria A. Jennings, Amanda L. Huff, Brady Zell, Jill M. Thompson, Phonphimon Wongthida, Jose Pulido, Matthew R. Schuelke, Adel Samson, Peter Selby, Elizabeth Ilett, Mark McNiven, Lewis R. Roberts, Mitesh J. Borad, Hardev Pandha, Kevin Harrington, Alan Melcher, Richard G. Vile

Συνεισφορές: Harrington, Kevin, Melcher, Alan

Πηγή: Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Θεματικοί όροι: 0301 basic medicine, T-Lymphocytes - immunology, RNA-Binding Proteins - metabolism, T-Lymphocytes, DNA-Binding Proteins - immunology, Inbred C57BL, Virus Replication, Vesicular stomatitis Indiana virus/immunology, Mice, Interferon-beta/immunology, Oncolytic Virotherapy, 0303 health sciences, Tumor, Oncolytic Viruses - physiology, Cancer Vaccines/administration & dosage, Oncolytic Viruses/immunology, RNA-Binding Proteins, 3. Good health, DNA-Binding Proteins, Oncolytic Viruses, Oncolytic Virotherapy/methods, Immunotherapy/methods, Female, Immunotherapy, RNA-Binding Proteins - genetics, Oncolytic Viruses - metabolism, DNA-Binding Proteins - metabolism, Science, Virus Replication/immunology, RNA-Binding Proteins - immunology, Immunotherapy - methods, Cancer Vaccines, Interferon-beta - metabolism, Article, Vesicular stomatitis Indiana virus, Cell Line, Cancer Vaccines - administration & dosage, 03 medical and health sciences, Oncolytic Virotherapy - methods, Cell Line, Tumor, Oncolytic Viruses - immunology, Animals, Humans, Virus Replication - immunology, T-Lymphocytes - metabolism, Vesicular stomatitis Indiana virus - immunology, Vesicular stomatitis Indiana virus - physiology, Interferon-beta, T-Lymphocytes/immunology, Interferon-beta - immunology, RNA-Binding Proteins/genetics, Mice, Inbred C57BL, DNA-Binding Proteins - genetics, 13. Climate action, Cancer Vaccines - immunology, Mutation, DNA-Binding Proteins/genetics, Vesicular stomatitis Indiana virus - metabolism

Περιγραφή αρχείου: Electronic; ?; application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41467-021-22115-1.pdf
https://pubmed.ncbi.nlm.nih.gov/33772027
https://doaj.org/article/0057781c39ce43a79a6659f6e847a415
https://eprints.whiterose.ac.uk/id/eprint/180096/
https://eprints.whiterose.ac.uk/id/eprint/230919/

Phase Ib/II trial of talimogene laherparepvec alone and with pembrolizumab in advanced solid tumors with liver metastases and hepatocellular carcinoma.

Συγγραφείς: Hecht, J.R., Oberoi, A., Garralda Cabanas, E., Jae Chon, H., Digklia, A., Rottey, S., Martin Jimenez, M., Chaney, M., Hippenmeyer, J., Lawrence, T., Liu, K., Hamidi, A., Chesney, J.

Θεματικοί όροι: Humans, Liver Neoplasms/drug therapy, Liver Neoplasms/secondary, Carcinoma, Hepatocellular/drug therapy, Hepatocellular/pathology, Hepatocellular/therapy, Female, Antibodies, Monoclonal, Humanized/therapeutic use, Humanized/adverse effects, Male, Middle Aged, Aged, Adult, Biological Products/therapeutic use, Biological Products/administration & dosage, Antineoplastic Agents, Immunological/therapeutic use, Immunological/adverse effects, Immunological/pharmacology, 80 and over, Oncolytic Virotherapy/methods, Herpesvirus 1, Human, hepatocellular carcinoma, liver metastasis, pembrolizumab, solid tumor

Relation: The Oncologist; https://iris.unil.ch/handle/iris/38230; serval:BIB_14A3EF9C1C3C

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/38230
https://doi.org/10.1093/oncolo/oyae203

Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1

Συγγραφείς: Cervera-Carrascon, Victor, Quixabeira, Dafne C. A., Santos, Joao M., Havunen, Riikka, Milenova, Ioanna, Verhoeff, Jan, Heiniö, Camilla, Zafar, Sadia, Garcia-Vallejo, Juan J., van Beusechem, Victor W., de Gruijl, Tanja D., Kalervo, Aino, Sorsa, Suvi, Kanerva, Anna, Hemminki, Akseli

Πηγή: Frontiers in immunology, 12:706517

Θεματικοί όροι: Female [MeSH], Immunology, Mice, Inbred C57BL [MeSH], Adenoviridae [MeSH], Oncolytic Virotherapy/methods [MeSH], Animals [MeSH], checkpoint inhibitor resistance, Programmed Cell Death 1 Receptor/antagonists, Tumor Necrosis Factor-alpha/immunology [MeSH], cancer immunotherapy, Mice [MeSH], Interleukin-2/immunology [MeSH], Melanoma, Experimental/pathology [MeSH], oncolytic virus, tumor microenvironment, adenovirus, Drug Resistance, Neoplasm [MeSH], Immune Checkpoint Inhibitors/pharmacology [MeSH]

Relation: https://repository.publisso.de/resource/frl:6478503; https://doi.org/10.3389/fimmu.2021.706517; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343222/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6478503
https://doi.org/10.3389/fimmu.2021.706517
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8343222/

Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies

Συγγραφείς: Heidbuechel, Johannes P. W., Engeland, Christine E.

Πηγή: http://lobid.org/resources/99370676930806441#!, 14(1):63.

Θεματικοί όροι: Measles virus, Immune checkpoint blockade, T-Lymphocytes/immunology [MeSH], Humans [MeSH], Bispecific T cell engagers, Oncolytic Virotherapy/methods [MeSH], CAR T cells, Tumor microenvironment, BiTE and ADCs for cancer therapy, Oncolytic Viruses/pathogenicity [MeSH], Immunotherapy/methods [MeSH], Vaccinia virus, Adenovirus, Review, Cancer immunotherapy, Oncolytic viruses, Tumor Microenvironment [MeSH], Viral vectors

Relation: https://repository.publisso.de/resource/frl:6463843; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052795/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6463843
https://doi.org/10.1186/s13045-021-01075-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052795/

Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry.

Συγγραφείς: Kulkarni, Amit, Ferreira, Tiago, Bretscher, Clemens, Grewenig, Annabel, El-Andaloussi, Nazim, Bonifati, Serena, Marttila, Tiina, PALISSOT, Valerie, Hossain, Jubayer A, AZUAJE, Francisco, Miletic, Hrvoje, Ystaas, Lars A R, GOLEBIEWSKA, Anna, NICLOU, Simone P., Roeth, Ralf, Niesler, Beate, Weiss, Amélie, Brino, Laurent, MARCHINI, Antonio

Πηγή: Nature Communications, 12 (1), 3834 (2021-06-22)

Θεματικοί όροι: Laminin, laminin gamma 1, GZP2782OP0 (N-Acetylneuraminic Acid), Animals, Cell Line, Tumor, Glioblastoma/pathology/therapy/virology, H-1 parvovirus/metabolism, HCT116 Cells, HEK293 Cells, HeLa Cells, Humans, Laminin/genetics/metabolism, Mice, Inbred NOD, SCID, N-Acetylneuraminic Acid/metabolism, Oncolytic Virotherapy/methods, Oncolytic Viruses/metabolism, Protein Binding, RNA Interference, Virus Attachment, Virus Internalization, Xenograft Model Antitumor Assays/methods, Human health sciences, Oncology, Sciences de la santé humaine, Oncologie

Relation: urn:issn:2041-1723; https://orbilu.uni.lu/handle/10993/60438; info:hdl:10993/60438; info:pmid:34158478

Διαθεσιμότητα: https://orbilu.uni.lu/handle/10993/60438
https://orbilu.uni.lu/bitstream/10993/60438/1/s41467-021-24034-7.pdf
https://doi.org/10.1038/s41467-021-24034-7

Talimogene laherparepvec treatment to overcome loco-regional acquired resistance to immune checkpoint blockade in tumor stage IIIB–IV M1c melanoma patients

Συγγραφείς: Fröhlich, Anne, Niebel, Dennis, Fietz, Simon, Egger, Eva, Buchner, Andrea, Sirokay, Judith, Landsberg, Jennifer

Πηγή: http://lobid.org/resources/99370671253406441#!, 69(5):759-769.

Θεματικοί όροι: Melanoma/therapy [MeSH], Costimulatory and Inhibitory T-Cell Receptors/antagonists, Disease Progression [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Progression-Free Survival [MeSH], Antineoplastic Agents, Immunological/pharmacology [MeSH], Advanced melanoma, Oncolytic Virotherapy/methods [MeSH], Original Article, Neoplasm Staging [MeSH], Immunotherapy/methods [MeSH], Male [MeSH], Melanoma/pathology [MeSH], Targeted therapy, Skin Neoplasms/immunology [MeSH], Female [MeSH], Follow-Up Studies [MeSH], Drug Resistance, Neoplasm/drug effects [MeSH], Adult [MeSH], Humans [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Skin Neoplasms/pathology [MeSH], Neoplasm/immunology [MeSH], Melanoma/mortality [MeSH], Herpesvirus 1

Relation: https://repository.publisso.de/resource/frl:6470336; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183503/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6470336
https://doi.org/10.1007/s00262-020-02487-x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183503/

Oncolytic Viruses as a Platform for the Treatment of Malignant Brain Tumors

Συγγραφείς: De Sostoa, Jana, Dutoit Vallotton, Valérie, Migliorini, Denis

Πηγή: ISSN: 1661-6596 ; International Journal of Molecular Sciences, vol. 21, no. 20 (2020) 7449.

Θεματικοί όροι: info:eu-repo/classification/ddc/616, Animals, Biomarkers, Tumor, Brain Neoplasms/genetics/therapy, Clinical Trials as Topic, Combined Modality Therapy, Drug Evaluation, Preclinical, Gene Transfer Techniques, Genetic Therapy/methods, Genetic Vectors/administration & dosage/genetics, Humans, Oncolytic Virotherapy/methods, Oncolytic Viruses/genetics, Transduction, Genetic, Treatment Outcome

Relation: info:eu-repo/semantics/altIdentifier/pmid/33050329; unige:150572

Διαθεσιμότητα: https://archive-ouverte.unige.ch/unige:150572

Survivin silencing and TRAIL expression using oncolytic adenovirus increase anti-tumorigenic activity in gemcitabine-resistant pancreatic cancer cells

Συγγραφείς: Zhezhu, Han, Seungha, Lee, Suyeon, Je, Chi-Yong, Eom, Hye Jin, Choi, Jae J, Song, Joo-Hang, Kim

Συνεισφορές: College of Medicine, Dept. of Internal Medicine, Zhezhu Han, Seungha Lee, Suyeon Je, Chi-Yong Eom, Hye Jin Choi, Jae J. Song, Joo-Hang Kim, Kim, Joo Hang, Song, Jae Jin, Choi, Hye Jin

Πηγή: Apoptosis. 21:351-364

Θεματικοί όροι: 0301 basic medicine, Deoxycytidine/analogs & derivatives, Antimetabolites, Antineoplastic, Antimetabolites, Antineoplastic/therapeutic use, Survivin, Nude, Drug Resistance, Down-Regulation, Mice, Nude, TRAIL, Apoptosis, Oncolytic adenovirus, Deoxycytidine, Cell Line, Oncolytic Virotherapy/methods, Adenoviridae, Inhibitor of Apoptosis Proteins, Mice, 03 medical and health sciences, shRNA, Cell Line, Tumor, Animals, Humans, Oncolytic Viruses, RNA, Small Interfering, Oncolytic Virotherapy, Tumor, Pancreatic Neoplasms/therapy, TNF-Related Apoptosis-Inducing Ligand/genetics, Pancreatic cancer, Xenograft Model Antitumor Assays, Gemcitabine, Combined Modality Therapy, 3. Good health, Pancreatic Neoplasms, HEK293 Cells, Small Interfering/genetics, Drug Resistance, Neoplasm, Neoplasm/genetics, Inhibitor of Apoptosis Proteins/genetics, RNA, Female, RNA Interference, Deoxycytidine/therapeutic use

Περιγραφή αρχείου: 351~364

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/26677013

Efficacy of HER2 retargeted herpes simplex virus as therapy for high-grade glioma in immunocompetent mice

Συγγραφείς: Reisoli E., Gambini E., Appolloni I., GATTA, VALENTINA, Barilari M., MENOTTI, LAURA, Malatesta P.

Πηγή: Cancer Gene Therapy. 19:788-795

Θεματικοί όροι: Oncolytic Virotherapy, 0301 basic medicine, Mice, Inbred BALB C, 0303 health sciences, Genetic Vectors, Antineoplastic Agents, Genetic Therapy, Glioma, Herpesvirus 1, Human, Kaplan-Meier Estimate, Virus Replication, Erb-b2 Receptor Tyrosine Kinases, 3. Good health, Mice, Oncolytic Viruses, 03 medical and health sciences, HSV, MURINE MODEL, ONCOLYTIC VIRUS, VIROTHERAPY, ANIMALS, Antineoplastic Agents/administration & dosage, Antineoplastic Agents/metabolism, Genetic Therapy/methods, Genetic Vectors/genetics, Genetic Vectors/metabolism, Glioma/chemically induced, Glioma/pathology, Glioma/therapy, Herpesvirus 1, Human/genetics, Human/metabolism, Human/physiology, Humans, Immunocompetence, MICE, Inbred BALB C, Oncolytic Virotherapy/methods, Oncolytic Viruses/genetics, Oncolytic Viruses/metabolism, Receptor, erbB-2/genetics, erbB-2/metabolism, Tumor Cells, Cultured, Tumor Cells, Cultured, Animals

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/cgt201262.pdf
https://pubmed.ncbi.nlm.nih.gov/22996742
https://hdl.handle.net/11567/491318
https://doi.org/10.1038/cgt.2012.62
https://hdl.handle.net/11585/127318
https://doi.org/10.1038/cgt.2012.62

The Molecular Basis of Herpesviruses as Oncolytic Agents

Συγγραφείς: MENOTTI, LAURA, CAMPADELLI, MARIA GABRIELLA, NANNI, PATRIZIA, LOLLINI, PIER LUIGI, DE GIOVANNI, CARLA

Πηγή: Current Pharmaceutical Biotechnology. 13:1795-1803

Θεματικοί όροι: Oncolytic Virotherapy, 0301 basic medicine, Clinical Trials as Topic, Oncolytic Viruses, 0303 health sciences, 03 medical and health sciences, HSV, HERPES SIMPLEX VIRUS, RETARGETING, ONCOLYTIC VIRUS, MURINE MODEL, ANIMALS, Drug Evaluation, Preclinical, HUMANS, Neoplasms/genetics, Neoplasms/metabolism, Neoplasms/therapy, Neoplasms/virology, Oncolytic Virotherapy/methods, Oncolytic Viruses/genetics, Oncolytic Viruses/metabolism, Oncolytic Viruses/physiology, Simplexvirus/genetics, Simplexvirus/metabolism, SIMPLEXVIRUS/PHYSIOLOGY, GLIOMA, gamma1 34.5, HER-2, Neoplasms, Drug Evaluation, Preclinical, Animals, Humans, Simplexvirus, 3. Good health

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/21740356

A Hypoxia- and α-Fetoprotein–Dependent Oncolytic Adenovirus Exhibits Specific Killing of Hepatocellular Carcinomas

Συγγραφείς: Oh-Joon, Kwon, Pyung-Hwan, Kim, Steven, Huyn, Lily, Wu, Minjung, Kim, Chae-Ok, Yun

Συνεισφορές: Oh-Joon Kwon, Pyung-Hwan Kim, Steven Huyn, Lily Wu, Minjung Kim, Chae-Ok Yun, Kwon, Oh Joon, Kim, Pyung Hwan, Yun, Chae Ok

Πηγή: Clinical Cancer Research. 16:6071-6082

Θεματικοί όροι: Male, 0301 basic medicine, Carcinoma, Hepatocellular, alpha-Fetoproteins/genetics, Nude, Mice, Nude, Apoptosis, Cell Line, Oncolytic Virotherapy/methods, Adenoviridae, Substrate Specificity, Promoter Regions, Mice, 03 medical and health sciences, Hepatocellular/pathology, Genetic, Cell Line, Tumor, Animals, Humans, Apoptosis*/physiology, Promoter Regions, Genetic, Liver Neoplasms/genetics, Hepatocellular/therapy, Oncolytic Virotherapy, 0303 health sciences, Tumor, Adenoviridae/physiology, Carcinoma, Liver Neoplasms, Substrate Specificity/genetics, Liver Neoplasms/pathology, Xenograft Model Antitumor Assays, Cell Hypoxia, 3. Good health, Adenoviridae/genetics, Liver Neoplasms/therapy, Cell Hypoxia/physiology, alpha-Fetoproteins, Hepatocellular/genetics

Περιγραφή αρχείου: 6071~6082

Σύνδεσμος πρόσβασης: https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/102781/1/T201004898.pdf
https://pubmed.ncbi.nlm.nih.gov/21169258

Tumor suppression by apoptotic and anti‐angiogenic effects of mortalin‐targeting adeno‐oncolytic virus

Συγγραφείς: Ji Young, Yoo, Jihoon, Ryu, Ran, Gao, Tomoko, Yaguchi, Sunil C, Kaul, Renu, Wadhwa, Chae-Ok, Yun

Συνεισφορές: Ji Young Yoo, Jihoon Ryu, Ran Gao, Tomoko Yaguchi, Sunil C. Kaul, Renu Wadhwa, Chae-Ok Yun, Yun, Chae Ok

Πηγή: The Journal of Gene Medicine. 12:586-595

Θεματικοί όροι: mortalin, 0301 basic medicine, Small Interfering/metabolism, Angiogenesis Inhibitors, Apoptosis, Transfection, Neoplasms/pathology, Neoplasms/therapy, Cell Line, Oncolytic Virotherapy/methods, Adenoviridae, angiogenesis, Mice, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Animals, Humans, HSP70 Heat-Shock Proteins, RNA, Small Interfering, Adenoviridae/metabolism, Tumor Suppressor Protein p53/metabolism, Oncolytic Virotherapy, 0303 health sciences, Tumor, Neoplasms/blood supply, Oncolytic Viruses/metabolism, apoptosis, HSP70 Heat-Shock Proteins/metabolism, Angiogenesis Inhibitors/metabolism, Xenograft Model Antitumor Assays, 3. Good health, Oncolytic Viruses, Cytoprotection, siRNA, RNA, cancer therapy, Tumor Suppressor Protein p53, adeno-oncolytic viruses

Περιγραφή αρχείου: 586~595

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/20603860