Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma

Authors: Zamani S. A., Wu L., Black E. L., Bartram A., Ng A. W. T., Secrier M., Perelman J. D., Ustaoglu A., Ococks E., Jacobson D., Devonshire G., Grehan N., Nutzinger B., Freeman A., Miremadi A., O'Donovan M., Frankell A. M., Killcoyne S., Bartlett F., Petty R. D., Coleman H., McManus D., Turkington R., Grabowska A., Moorthy K., Peters C. J., Hanna G. B., Lishman S., Sothi S., Scott M., Haidry R., Lovat L., Saunders J., Kaye P., Soomro I., Parsons S. L., Sreedharan L., Kumar B., Cheong E., Chan D., Berrisford R., Sanders G., Ciccarelli F. D., Goh V., Mahadeva U., Chang F., Davies A., Gossage J., Lagergren J., Grace B. L., Walker R. C., Underwood T. J., Contino G., Puig S., Taniere P., Beggs A., Tucker O., O'Neill J. R., Hupp T. R., Skipworth R. J. E., Save V., Bagwan I., Preston S. R., Sharrocks A., Ang Y., Hayes S. J., Sujendran V., Hindmarsh A., Safranek P., Hardwick R. H., Carroll N., Crichton C., Davies J., Jammula S., Eldridge M., Millington C., Coles H., Cheah C., Tripathi M., Malhotra S., Smyth E. C., Abbas S., Loreno C., Redmond A. M., Edwards P. A. W., Coleman H. G., Fitzgerald R. C.

Contributors: S.A. Zamani, L. Wu, E.L. Black, A. Bartram, A.W.T. Ng, M. Secrier, J.D. Perelman, A. Ustaoglu, E. Ocock, D. Jacobson, G. Devonshire, N. Grehan, B. Nutzinger, A. Freeman, A. Miremadi, M. O'Donovan, A.M. Frankell, S. Killcoyne, F. Bartlett, R.D. Petty, H. Coleman, D. Mcmanu, R. Turkington, A. Grabowska, K. Moorthy, C.J. Peter, G.B. Hanna, S. Lishman, S. Sothi, M. Scott, R. Haidry, L. Lovat, J. Saunder, P. Kaye, I. Soomro, S.L. Parson, L. Sreedharan, B. Kumar, E. Cheong, D. Chan, R. Berrisford, G. Sander, F.D. Ciccarelli, V. Goh, U. Mahadeva, F. Chang, A. Davie, J. Gossage, J. Lagergren, B.L. Grace, R.C. Walker, T.J. Underwood, G. Contino, S. Puig, P. Taniere, A. Begg, O. Tucker, J.R. O'Neill, T.R. Hupp, R.J.E. Skipworth, V. Save, I. Bagwan, S.R. Preston, A. Sharrock, Y. Ang, S.J. Haye, V. Sujendran, A. Hindmarsh, P. Safranek, R.H. Hardwick, N. Carroll, C. Crichton, J. Davie, S. Jammula, M. Eldridge, C. Millington, H. Cole, C. Cheah, M. Tripathi, S. Malhotra, E.C. Smyth, S. Abba, C. Loreno, A.M. Redmond, P.A.W. Edward, H.G. Coleman, R.C. Fitzgerald

Subject Terms: Settore BIOS-08/A - Biologia molecolare

Relation: info:eu-repo/semantics/altIdentifier/pmid/41991688; info:eu-repo/semantics/altIdentifier/wos/WOS:001741931300001; volume:32; issue:5; firstpage:1805; lastpage:1816; numberofpages:12; journal:NATURE MEDICINE; https://hdl.handle.net/2434/1249176

Availability: https://hdl.handle.net/2434/1249176
https://doi.org/10.1038/s41591-026-04331-8

Longitudinal tracking of 97 esophageal adenocarcinomas using liquid biopsy sampling

Authors: Ococks, E. ^{1, †}, Frankell, A.M. ^{1, †}, Masque Soler, N. ^{1, †}, Grehan, N. ¹, Northrop, A. ¹, Coles, H. ¹, Redmond, A.M. ¹, Devonshire, G. ², Weaver, J.M.J. ¹, Hughes, C. ¹, Lehovsky, K. ¹, Blasko, A. ¹, Nutzinger, B. ¹, Fitzgerald, R.C. ^{1, ∗∗, ‡}, Smyth, E. ^{3, ∗, ‡}

Source: In Annals of Oncology April 2021 32(4):522-532

Understanding the malignant potential of gastric metaplasia of the oesophagus and its relevance to Barrett's oesophagus surveillance: Individual-level data analysis

Authors: Black E. L., Ococks E., Devonshire G., Ng A. W. T., O'Donovan M., Malhotra S., Tripathi M., Ciccarelli FD, Miremadi A., Freeman A., Coles H., Fitzgerald R. C.

Contributors: E.L. Black, E. Ocock, G. Devonshire, A.W.T. Ng, M. O'Donovan, S. Malhotra, M. Tripathi, F. Ciccarelli, A. Miremadi, A. Freeman, H. Cole, R.C. Fitzgerald

Subject Terms: Barrett's metaplasia, Barrett's oesophagu, gastric metaplasia, oesophageal cancer, surveillance, Settore BIOS-08/A - Biologia molecolare

Relation: info:eu-repo/semantics/altIdentifier/pmid/37989565; info:eu-repo/semantics/altIdentifier/wos/WOS:001109636100001; volume:73; issue:5; firstpage:729; lastpage:740; numberofpages:12; journal:GUT; https://hdl.handle.net/2434/1249239

Availability: https://hdl.handle.net/2434/1249239
https://doi.org/10.1136/gutjnl-2023-330721

Serial ctDNA detection using a personalized, tumor-informed assay in esophageal adenocarcinoma patients following resection

Authors: Ococks, E, Sharma, S, Tian Ng, AW, Aleshin, A, Fitzgerald, RC, Smyth, E, OCCAMS Consortium, ., Edwards, PAW, Grehan, N, Nutzinger, B, Fidziukiewicz, E, Redmond, AM, Northrop, A, Abbas, S, Smyth, EC, O'Donovan, M, Miremadi, A, Malhotra, S, Tripathi, M, Grantham, A, Cheah, C, Coles, H, Flint, C, Eldridge, M, Secrier, M, Devonshire, G, Jammula, S, Davies, J, Crichton, C, Carroll, N, Hardwick, RH, Safranek, P, Hindmarsh, A, Sujendran, V, Hayes, SJ, Ang, Y, Sharrocks, A, Preston, SR, Bagwan, I, Save, V, Skipworth, RJE, Hupp, TR, O'Neill, JR, Tucker, O, Beggs, A, Taniere, P, Puig, S, Contino, G, Underwood, TJ, Walker, RC, Grace, BL, Lagergren, J, Gossage, J, Davies, A, Chang, F, Mahadeva, U, Goh, V, Ciccarelli, FD, Sanders, G, Berrisford, R, Chan, D, Cheong, E, Kumar, B, Sreedharan, L, Parsons, SL, Soomro, I, Kaye, P, Saunders, J, Lovat, L, Haidry, R, Scott, M, Sothi, S, Lishman, S, Hanna, GB, Peters, CJ, Moorthy, K, Grabowska, A, Turkington, R, McManus, D, Coleman, H, Petty, RD

Access URL: https://discovery-pp.ucl.ac.uk/id/eprint/10131919/

Serial Circulating tumor DNA detection using a personalized, tumor-informed assay in esophageal adenocarcinoma patients following resection

Authors: Ococks, E, Sharma, S, Ng, AWT, Aleshin, A, Fitzgerald, RC, Smyth, E

Source: 1708.e2 ; 1705

Subject Geographic: United States

Relation: Gastroenterology; http://hdl.handle.net/10044/1/102174

Availability: http://hdl.handle.net/10044/1/102174
https://doi.org/10.1053/j.gastro.2021.07.011

370P Bespoke circulating tumour DNA assay for the detection of minimal residual disease in esophageal adenocarcinoma patients

Authors: Ococks, E., Ng, A., Devonshire, G., Dashner, S., Chan, W-C., Sharma, S., Wu, H-T., Redmond, A., Northrop, A., Grehan, N., Sethi, H., Zimmermann, B., Smyth, E., Aleshin, A., Fitzgerald, R.

Source: Annals of Oncology ; volume 31, page S1317-S1318 ; ISSN 0923-7534

Availability: http://dx.doi.org/10.1016/j.annonc.2020.10.594
https://api.elsevier.com/content/article/PII:S0923753420431229?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0923753420431229?httpAccept=text/plain

The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic

Authors: Frankell, AM, Jammula, S, Li, X, Contino, G, Killcoyne, S, Abbas, S, Perner, J, Bower, L, Devonshire, G, Ococks, E, Grehan, N, Mok, J, O'Donovan, M, MacRae, S, Eldridge, MD, Tavaré, S, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS, ., Fitzgerald, RC

Source: Nature Genetics , 51 pp. 506-516. (2019)

Subject Terms: Bioinformatics, Gastrointestinal cancer, Genomics, Oesophageal diseases, Translational research

File Description: text

Relation: https://discovery.ucl.ac.uk/id/eprint/10069342/10/Lovat_The%20landscape%20of%20selection%20in%20551%20esophageal%20adenocarcinomas%20defines%20genomic%20biomarkers%20for%20the%20clinic_AAM2.pdf; https://discovery.ucl.ac.uk/id/eprint/10069342/

Availability: https://discovery.ucl.ac.uk/id/eprint/10069342/10/Lovat_The%20landscape%20of%20selection%20in%20551%20esophageal%20adenocarcinomas%20defines%20genomic%20biomarkers%20for%20the%20clinic_AAM2.pdf
https://discovery.ucl.ac.uk/id/eprint/10069342/

Assessing the clinical utility of circulating tumour DNA through longitudinal liquid biopsy sampling in oesophageal adenocarcinoma

Authors: Ococks, E., Frankell, A., Masque-Soler, N., Northrop, A., Devonshire, G., Hughes, C., Grehan, N., Smyth, E., Blasko, A., Fitzgerald, R.

Source: Annals of Oncology ; volume 30, page v315 ; ISSN 0923-7534

Availability: http://dx.doi.org/10.1093/annonc/mdz247.148
https://api.elsevier.com/content/article/PII:S0923753419590378?httpAccept=text/xml
https://api.elsevier.com/content/article/PII:S0923753419590378?httpAccept=text/plain
http://academic.oup.com/annonc/article-pdf/30/Supplement_5/mdz247.148/30084664/mdz247.148.pdf

121MO ctDNA and prognosis in resected esophageal adenocarcinoma (EAC)

Authors: Ococks, E. ¹, Frankell, A.M. ¹, Soler, N. Masque ¹, Northrop, A. ¹, Coles, H. ¹, Grehan, N. ², Redmond, A. ¹, Hughes, C. ², Devonshire, G. ³, Blasko, A. ¹, O. Oesophageal Cancer Clinical Molecular Stratification Consortium ¹, Fitzgerald, R. ¹, Smyth, E. ²

Source: In Annals of Oncology November 2020 31 Supplement 6:S1290-S1290

1491P Bespoke circulating tumor DNA assay for the detection of minimal residual disease in esophageal adenocarcinoma patients

Authors: Ococks, E. ¹, Ng, A. ², Devonshire, G. ², Dashner, S. ³, Chan, W-C. ³, Sharma, S. ³, Wu, H-T. ³, Redmond, A. ¹, Northrop, A. ¹, Grehan, N. ⁴, Sethi, H. ³, Zimmermann, B. ³, Smyth, E.C. ⁵, Aleshin, A. ⁶, Fitzgerald, R.C. ¹, Oesophageal Cancer Clinical Molecular Stratification (OCCAMS) Consortium, T. ¹

Source: In Annals of Oncology September 2020 31 Supplement 4:S926-S926

A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels.

Authors: McCoull D; LifeArc, Stevenage, UK., Ococks E; LifeArc, Stevenage, UK., Large JM; LifeArc, Stevenage, UK., Tickle DC; LifeArc, Stevenage, UK., Mathie A; Medway School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK., Jerman J; LifeArc, Stevenage, UK., Wright PD; LifeArc, Stevenage, UK.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Mar; Vol. 26 (3), pp. 428-438. Date of Electronic Publication: 2020 Dec 29.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

MeSH Terms: High-Throughput Screening Assays*, Potassium Channels, Tandem Pore Domain/*genetics , Small Molecule Libraries/*pharmacology, Baculoviridae/genetics ; Baculoviridae/metabolism ; Drug Discovery/methods ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Potassium/metabolism ; Potassium Channels, Tandem Pore Domain/agonists ; Potassium Channels, Tandem Pore Domain/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Thallium/metabolism ; Cell Line, Tumor ; Cloning, Molecular ; Gene Expression ; Humans ; Ion Transport

Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.

Authors: Wright PD; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK. Electronic address: Paul.wright@lifearc.org., Veale EL; Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK., McCoull D; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Tickle DC; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Large JM; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Ococks E; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Gothard G; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Kettleborough C; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK., Mathie A; Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, ME4 4TB, UK., Jerman J; LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX, UK.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Nov 04; Vol. 493 (1), pp. 444-450. Date of Electronic Publication: 2017 Sep 05.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

MeSH Terms: Drug Evaluation, Preclinical/*methods , Ion Channel Gating/*physiology , Naphthalenes/*administration & dosage , Naphthalenes/*chemistry , Potassium/*metabolism , Potassium Channels, Tandem Pore Domain/*agonists , Potassium Channels, Tandem Pore Domain/*metabolism, Ion Channel Gating/drug effects ; Potassium/chemistry ; Porosity ; Protein Domains ; Structure-Activity Relationship ; Terbinafine