Plant-based neuroprotection against memory impairment: Insights from Drosophila melanogaster models of neurodegenerative diseases.

Συγγραφείς: Cynthia Irene Kasi; Department of Biotechnology, Vel Tech Rangarajan & Dr. Sagunthala R&D Institute of Science and Technology, Avadi, Chennai 600062, India., Azhagu Saravana Babu Packirisamy; Department of Biotechnology, Vel Tech Rangarajan & Dr. Sagunthala R&D Institute of Science and Technology, Avadi, Chennai 600062, India., Meivelu Moovendhan; Natural Products Research Laboratory, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 602105, Tamil Nadu, India. Electronic address: moovendhan85@gmail.com.

Πηγή: Neuroscience [Neuroscience] 2026 Aug 28; Vol. 610, pp. 255-272. Date of Electronic Publication: 2026 Jun 17.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neurodegenerative Diseases*/drug therapy , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Memory Disorders*/drug therapy , Neuroprotection*/drug effects , Phytochemicals*/therapeutic use , Phytochemicals*/pharmacology, Animals ; Drosophila melanogaster ; Disease Models, Animal ; Humans

Oligosaccharide esters with neuroprotective activities isolated from the roots of Polygala tenuifolia Willd.

Συγγραφείς: Guo Y; School of Graduate, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Liu X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Ding M; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Wang Q; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Xie P; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China., Zhang H; School of Graduate, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Tianjin University of Technology, Tianjin, 300384, China. Electronic address: zhanghb626@163.com., Jiang Y; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 10019, China. Electronic address: yongjiang@bjmu.edu.cn.

Πηγή: Phytochemistry [Phytochemistry] 2026 Aug; Vol. 248, pp. 114905. Date of Electronic Publication: 2026 Mar 31.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Polygala*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/isolation & purification , Plant Roots*/chemistry , Oligosaccharides*/chemistry , Oligosaccharides*/isolation & purification , Oligosaccharides*/pharmacology , Esters*/chemistry , Esters*/isolation & purification , Esters*/pharmacology, Hydrogen Peroxide/pharmacology ; Oxidative Stress/drug effects ; Humans ; Molecular Structure ; Structure-Activity Relationship

The Synergistic Neuroprotective Effect of Honokiol and Magnolol Against Amyloid-β and MPP⁺-Induced Neurotoxicity in SH-SY5Y Cells: An Antioxidant, Molecular Orbital, and ADMET Study.

Συγγραφείς: Suwansukho B; Department of Pharmacognosy, Faculty of Pharmacy, Srinakharinwirot University, Ongkharak, Nakhon Nayok 26120, Thailand., Poempul K; Department of Pharmacognosy, Faculty of Pharmacy, Srinakharinwirot University, Ongkharak, Nakhon Nayok 26120, Thailand., Samee W; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Srinakharinwirot University, Ongkharak, Nakhon Nayok 26120, Thailand., Tadtong S; Department of Pharmacognosy, Faculty of Pharmacy, Srinakharinwirot University, Ongkharak, Nakhon Nayok 26120, Thailand.

Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Jul 08; Vol. 27 (14). Date of Electronic Publication: 2026 Jul 08.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lignans*/pharmacology , Lignans*/chemistry , Biphenyl Compounds*/pharmacology , Biphenyl Compounds*/chemistry , Biphenyl Compounds*/pharmacokinetics , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Amyloid beta-Peptides*/toxicity , Antioxidants*/pharmacology , Antioxidants*/chemistry , 1-Methyl-4-phenylpyridinium*/toxicity, Reactive Oxygen Species/metabolism ; Allyl Compounds ; Phenols ; Humans ; Cell Line, Tumor ; Drug Synergism

Synthesis and neuroprotective activity evaluation of diosgenin derivatives based on a biocatalytic-chemosynthetic combinatorial strategy.

Συγγραφείς: Li C; The Affiliated People's Hospital, College of Integrative Medicine, Fujian-Hong Kong-Macau-Taiwan Collaborative Laboratory for the Inheritance and Innovation of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China., Sun J; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China., Han J; The Affiliated People's Hospital, College of Integrative Medicine, Fujian-Hong Kong-Macau-Taiwan Collaborative Laboratory for the Inheritance and Innovation of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China., Lin Y; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China., Fan R; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China., Yang J; Yichang Humanwell Pharmaceutical CO., LTD., Yichang, 443000, China., Feng Y; The Affiliated People's Hospital, College of Integrative Medicine, Fujian-Hong Kong-Macau-Taiwan Collaborative Laboratory for the Inheritance and Innovation of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China. Electronic address: 2022029@fjtcm.edu.cn., Xu W; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China; Fujian Health College, Fuzhou, Fujian, 350101, China. Electronic address: 2000017@fjtcm.edu.cn., Li H; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China. Electronic address: lihua@fjtcm.edu.cn., Xu S; Institute of Structural Pharmacology & TCM Chemical Biology, Fujian Key Laboratory of Chinese Materia Medica, College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, China. Electronic address: xushaohua@fjtcm.edu.cn.

Πηγή: European journal of medicinal chemistry [Eur J Med Chem] 2026 Jul 05; Vol. 311, pp. 118825. Date of Electronic Publication: 2026 Apr 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Diosgenin*/pharmacology , Diosgenin*/chemical synthesis , Diosgenin*/chemistry , Diosgenin*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemical synthesis , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/metabolism, Apoptosis/drug effects ; Neurons/drug effects ; Signal Transduction/drug effects ; Animals ; Biocatalysis ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Humans

Neuroprotective potential of resveratrol in Parkinson, Huntington, amyotrophic lateral sclerosis, and multiple sclerosis: a comprehensive review.

Συγγραφείς: Shahsavari K; School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Yazarlu O; Department of General Surgery, Mashhad University of Medical Sciences, Mashhad, Iran. yazarlouom@mums.ac.ir., Ahmadnia H; Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran., Ardakani MT; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Khanavi M; Department of Pharmacognosy, Faculty of Pharmacy, and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran. khanavim@tums.ac.ir., Esfahani HM; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Abdollahzadeh R; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Sajedi A; MS and Neurology study group, Regenerative biomedicine Department, Royan institute for stem cell biology and technology and Arya group for treatment and research in MS and Neurological disease Tehran, Tehran, Iran., Kazemizadeh H; Thoracic Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran., Hasanpour M; Department of Pharmacognosy, Faculty of Pharmacy, and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran. mhasanpour@farabi.tums.ac.ir.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. mhasanpour@farabi.tums.ac.ir.

Πηγή: Molecular biology reports [Mol Biol Rep] 2026 Jul 04; Vol. 53 (1). Date of Electronic Publication: 2026 Jul 04.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Resveratrol*/pharmacology , Resveratrol*/therapeutic use , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Amyotrophic Lateral Sclerosis*/drug therapy , Amyotrophic Lateral Sclerosis*/metabolism , Multiple Sclerosis*/drug therapy , Multiple Sclerosis*/metabolism , Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Huntington Disease*/drug therapy , Huntington Disease*/metabolism, Mitochondria/drug effects ; Mitochondria/metabolism ; Sirtuin 1/metabolism ; Humans ; Animals

Isoquinoline alkaloids from Stephania japonica var. discolor and their neuroprotective effects against OGD/R-induced oxidative injury.

Συγγραφείς: Du J; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Xiao J; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Zhou D; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Chen G; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, PR China., Wang Y; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: wyj666163@163.com., Li N; School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang 110016, PR China. Electronic address: liningsypharm@163.com.

Πηγή: Fitoterapia [Fitoterapia] 2026 Jul; Vol. 192, pp. 107338. Date of Electronic Publication: 2026 Jun 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Alkaloids*/pharmacology , Alkaloids*/isolation & purification , Isoquinolines*/pharmacology , Isoquinolines*/isolation & purification , Oxidative Stress*/drug effects , Stephania*/chemistry , Reperfusion Injury*/drug therapy, Reactive Oxygen Species/metabolism ; Antioxidants/pharmacology ; Antioxidants/isolation & purification ; Cell Survival/drug effects ; Glucose/metabolism ; Plant Extracts/pharmacology ; Oxygen/metabolism ; Plants, Medicinal/chemistry ; Animals ; Rats ; PC12 Cells

SCR Organism: Stephania japonica

Discovery of Q-Markers of Mudan Granules by Chemical Profile, Pharmacokinetics, Neuroprotective Effect Evaluation, and Network Pharmacology.

Συγγραφείς: Wang Z; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Center of Translational Pharmacy, Jinhua Institute of Zhejiang University, Jinhua, China., Zhang S; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Center of Translational Pharmacy, Jinhua Institute of Zhejiang University, Jinhua, China., Hu C; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Center of Translational Pharmacy, Jinhua Institute of Zhejiang University, Jinhua, China., Wang S; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Innovation Center of Translational Pharmacy, Jinhua Institute of Zhejiang University, Jinhua, China.

Πηγή: Biomedical chromatography : BMC [Biomed Chromatogr] 2026 Jul; Vol. 40 (7), pp. e70494.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Drugs, Chinese Herbal*/pharmacokinetics , Drugs, Chinese Herbal*/chemistry , Drugs, Chinese Herbal*/pharmacology , Drugs, Chinese Herbal*/analysis , Neuroprotective Agents*/pharmacokinetics , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/analysis, Chromatography, High Pressure Liquid/methods ; Liquid Chromatography-Mass Spectrometry/methods ; Biomarkers/analysis ; Schwann Cells/drug effects ; Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Network Pharmacology

A new seco-iridoid glycoside from fruits of Cornus officinalis Sieb. et Zucc and their neuroprotective activities.

Συγγραφείς: Yang M; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Hao ZY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Wang XL; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.; Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan, China., Zhou SQ; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Xiao CY; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Zheng XK; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China., Feng WS; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, Henan, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou, Henan, China.

Πηγή: Natural product research [Nat Prod Res] 2026 Jul; Vol. 40 (13), pp. 3772-3782. Date of Electronic Publication: 2025 Apr 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cornus*/chemistry , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Iridoid Glycosides*/chemistry , Iridoid Glycosides*/isolation & purification , Iridoid Glycosides*/pharmacology, Fruit/chemistry ; Apoptosis/drug effects ; Molecular Structure ; Animals

Design, synthesis and anti-Parkinson's disease bioactivity evaluation of isoquinoline derivatives as potent IDO1/TDO dual inhibitors.

Συγγραφείς: Yang Z; Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, PR China., Lin Z; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China., Yang C; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China., Lu R; Department of Pharmacy/Evidence-Based Pharmacy Center, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Children's Medicine Key Laboratory of Sichuan Province, NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address: lurunxin@scu.edu.cn., Wu Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, PR China. Electronic address: wyong@scu.edu.cn.

Πηγή: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2026 Jul; Vol. 136, pp. 130596. Date of Electronic Publication: 2026 Feb 22.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Indoleamine-Pyrrole 2,3,-Dioxygenase*/antagonists & inhibitors , Indoleamine-Pyrrole 2,3,-Dioxygenase*/metabolism , Isoquinolines*/pharmacology , Isoquinolines*/chemistry , Isoquinolines*/chemical synthesis , Isoquinolines*/therapeutic use , Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Tryptophan Oxygenase*/antagonists & inhibitors , Tryptophan Oxygenase*/metabolism , Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Neuroprotective Agents*/chemical synthesis , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Drug Design*, Animals ; Humans ; Structure-Activity Relationship ; Rats ; Molecular Structure ; Dose-Response Relationship, Drug ; Mice

Discovery of tetrahydroisoquinoline derivatives as selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting activities and neuroprotective activities.

Συγγραφείς: Liu S; Shaanxi Key Labotory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, PR China., Dang B; Shaanxi Key Labotory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, PR China., Kang Z; Shaanxi Key Labotory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, PR China., Wei R; Shaanxi Key Labotory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, PR China., Yang Z; College of Medicinal and Chemical Engineering, Shaanxi A&F Technology University, Yangling, Shannxi 712100, PR China., Guo X; College of Medicinal and Chemical Engineering, Shaanxi A&F Technology University, Yangling, Shannxi 712100, PR China., Shao F; College of Medicinal and Chemical Engineering, Shaanxi A&F Technology University, Yangling, Shannxi 712100, PR China., Li Z; Department of Student Affairs, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, PR China., Xing L; Guangxi Key Laboratory of Urban Water Environment, College of Chemistry and Environmental Engineering, Baise University, Baise 533000, PR China. Electronic address: 1094895479@qq.com., Hu J; College of Medicinal and Chemical Engineering, Shaanxi A&F Technology University, Yangling, Shannxi 712100, PR China. Electronic address: hujiadong@aliyun.com., Chen X; Shaanxi Key Labotory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, PR China. Electronic address: chenxin1888@nwsuaf.edu.cn.

Πηγή: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2026 Jul; Vol. 136, pp. 130593. Date of Electronic Publication: 2026 Feb 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Histone Deacetylase Inhibitors*/pharmacology , Histone Deacetylase Inhibitors*/chemistry , Histone Deacetylase Inhibitors*/chemical synthesis , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/chemical synthesis , Histone Deacetylase 6*/antagonists & inhibitors , Histone Deacetylase 6*/metabolism , Tetrahydroisoquinolines*/pharmacology , Tetrahydroisoquinolines*/chemistry , Tetrahydroisoquinolines*/chemical synthesis , Neuronal Outgrowth*/drug effects , Neurites*/drug effects , Drug Discovery*, Histone Deacetylases/metabolism ; Animals ; Rats ; Structure-Activity Relationship ; PC12 Cells ; Molecular Structure ; Humans ; Dose-Response Relationship, Drug

Tolypaxillines A-J: indole diterpenoids with neuroprotective activities from a soil-derived fungus Tolypocladium album DWS131.

Συγγραφείς: Tan YF; Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; The Hunan Institute of Pharmacy Practice and Clinical Research, Changsha, 410008, PR China., Chen XY; Eye Center of Xiangya Hospital, Central South University, Changsha, 410008, PR China; Hunan Key Laboratory of Ophthalmology, Changsha, 410008, PR China., Wang C; Eye Center of Xiangya Hospital, Central South University, Changsha, 410008, PR China; Hunan Key Laboratory of Ophthalmology, Changsha, 410008, PR China., Liang AL; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China., Lu WY; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China., Feng LM; Eye Center of Xiangya Hospital, Central South University, Changsha, 410008, PR China; Hunan Key Laboratory of Ophthalmology, Changsha, 410008, PR China., Huang Q; Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; The Hunan Institute of Pharmacy Practice and Clinical Research, Changsha, 410008, PR China., Jiang YP; Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; The Hunan Institute of Pharmacy Practice and Clinical Research, Changsha, 410008, PR China., Liu S; Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; The Hunan Institute of Pharmacy Practice and Clinical Research, Changsha, 410008, PR China., Xia XB; Eye Center of Xiangya Hospital, Central South University, Changsha, 410008, PR China; Hunan Key Laboratory of Ophthalmology, Changsha, 410008, PR China., Li J; Department of Pharmacy, National Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; The Hunan Institute of Pharmacy Practice and Clinical Research, Changsha, 410008, PR China. Electronic address: lijingliyun@csu.edu.cn., Wang WX; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China. Electronic address: wangwenxuan@csu.edu.cn.

Πηγή: Phytochemistry [Phytochemistry] 2026 Jul; Vol. 247, pp. 114855. Date of Electronic Publication: 2026 Mar 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Diterpenes*/chemistry , Diterpenes*/pharmacology , Diterpenes*/isolation & purification , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Indoles*/chemistry , Indoles*/pharmacology , Indoles*/isolation & purification , Hypocreales*/chemistry, Glutamic Acid/pharmacology ; Animals ; Molecular Structure ; Rats ; Soil Microbiology ; Structure-Activity Relationship ; Dose-Response Relationship, Drug

Structural elucidation, antioxidant and neuroprotective features of Physalis pubescens L. polysaccharide and its selenium-modified product.

Συγγραφείς: Tan Y; College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, PR China., Qiu L; College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, PR China., Li D; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, PR China.; Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang University of Chemical Technology, Shenyang, PR China., Liu X; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, PR China.; National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Shenyang University of Chemical Technology, Shenyang, PR China., Gao P; College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, PR China.; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, PR China.

Πηγή: Natural product research [Nat Prod Res] 2026 Jul; Vol. 40 (13), pp. 3958-3966. Date of Electronic Publication: 2025 Apr 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Antioxidants*/chemistry , Antioxidants*/pharmacology , Antioxidants*/isolation & purification , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Selenium*/chemistry , Polysaccharides*/chemistry , Polysaccharides*/pharmacology , Polysaccharides*/isolation & purification , Physalis*/chemistry, Fruit/chemistry ; Animals ; Molecular Structure ; Molecular Weight ; Spectroscopy, Fourier Transform Infrared ; Magnetic Resonance Spectroscopy

New Monoterpenoid Indole Alkaloids as Potential Neuroprotective Agents from Uncaria hirsuta Haviland.

Συγγραφείς: Huang XY; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Cui J; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Wang WL; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Zhou HZ; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Jiang YC; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., He X; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Chen HL; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Li LM; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China.

Πηγή: Molecules (Basel, Switzerland) [Molecules] 2026 Jun 11; Vol. 31 (12). Date of Electronic Publication: 2026 Jun 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/isolation & purification , Secologanin Tryptamine Alkaloids*/chemistry , Secologanin Tryptamine Alkaloids*/pharmacology , Secologanin Tryptamine Alkaloids*/isolation & purification , Uncaria*/chemistry , Indole Alkaloids*/chemistry , Indole Alkaloids*/pharmacology, Reactive Oxygen Species/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Neurons/drug effects ; Neurons/metabolism ; Plant Leaves/chemistry ; Animals ; Molecular Structure ; Mice ; Cell Line ; Magnetic Resonance Spectroscopy

Evaluation of Umbelliferone Neuroprotective Effects Against Acrylamide-Induced Oxidative Stress, In Vivo and In Silico Study.

Συγγραφείς: Mogadem A; Department of Chemistry, College of Science, Taibah University, Madinah, Saudi Arabia. amogadam@taibahu.edu.sa., Al-Refai HH; Department of Chemistry, College of Science in Yanbu, Taibah University, Yanbu Governorate, Saudi Arabia.

Πηγή: Journal of molecular neuroscience : MN [J Mol Neurosci] 2026 Jun 10; Vol. 76 (2). Date of Electronic Publication: 2026 Jun 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Humana Press Country of Publication: United States NLM ID: 9002991 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1166 (Electronic) Linking ISSN: 08958696 NLM ISO Abbreviation: J Mol Neurosci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Umbelliferones*/pharmacology , Umbelliferones*/therapeutic use , Acrylamide*/toxicity , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Antioxidants*/pharmacology , Antioxidants*/therapeutic use , Oxidative Stress*, Tumor Necrosis Factor-alpha/metabolism ; Tumor Necrosis Factor-alpha/genetics ; Liver/drug effects ; Liver/metabolism ; Heme Oxygenase-1/metabolism ; Heme Oxygenase-1/genetics ; Caspase 3/metabolism ; Caspase 3/genetics ; Brain/metabolism ; Brain/drug effects ; Alanine Transaminase/metabolism ; Animals ; Mice ; Male ; Molecular Docking Simulation ; Lipid Peroxidation

Neuroprotective effects of pepsin-hydrolyzed ovotransferrin on H2O2-induced oxidative damage in SH-SY5Y neuronal cells.

Συγγραφείς: Kim HJ; Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea., Yu SW; Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea., Kim KT; Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea; Research Institute, WithBio Inc., Seoul 05029, Republic of Korea., Ahn DU; Department of Animal Science, Iowa State University, Ames, IA, 50011, USA., Lee NK; Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea; Research Institute, WithBio Inc., Seoul 05029, Republic of Korea., Paik HD; Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea; Research Institute, WithBio Inc., Seoul 05029, Republic of Korea. Electronic address: hdpaik@konkuk.ac.kr.

Πηγή: Bioorganic chemistry [Bioorg Chem] 2026 Jun 05; Vol. 173, pp. 109613. Date of Electronic Publication: 2026 Feb 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Oxidative Stress*/drug effects , Conalbumin*/pharmacology , Conalbumin*/chemistry , Pepsin A*/metabolism , Pepsin A*/chemistry , Hydrogen Peroxide*/pharmacology , Hydrogen Peroxide*/antagonists & inhibitors , Neurons*/drug effects , Neurons*/metabolism , Antioxidants*/pharmacology , Antioxidants*/chemistry, Cell Survival/drug effects ; Apoptosis/drug effects ; Reactive Oxygen Species/metabolism ; Humans ; Hydrolysis ; Dose-Response Relationship, Drug ; Cell Line, Tumor ; Structure-Activity Relationship

Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke.

Συγγραφείς: Wang Q; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China., Li W; Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qian Fo Shan Hospital, Jinan, China., Wu D; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China., Xu S; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China., Ji X; Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.; Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.

Πηγή: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2026 Jun; Vol. 32 (6), pp. e70960.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neuroprotective Agents*/therapeutic use , Neuroprotective Agents*/pharmacology , Phenothiazines*/therapeutic use , Phenothiazines*/pharmacology , Ischemic Stroke*/drug therapy , Ischemic Stroke*/metabolism , Brain Ischemia*/drug therapy, Promethazine/therapeutic use ; Humans ; Animals

Novel (+)-usnic acid derivatives, computational studies and biological evaluation as neuroprotective agents.

Συγγραφείς: Kumar G; Department of Pharmacy, Vidya Vihar, Birla Institute of Technology and Science Pilani, Pilani, India., Kumar R; Department of Biological Sciences, National Institute of Pharmaceutical Education and Research-Hyderabad, Hyderabad, India., Tanish; Department of Pharmacy, Vidya Vihar, Birla Institute of Technology and Science Pilani, Pilani, India., Singh SB; Department of Biological Sciences, National Institute of Pharmaceutical Education and Research-Hyderabad, Hyderabad, India.; Dr. B.R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi, India.

Πηγή: Future medicinal chemistry [Future Med Chem] 2026 Jun; Vol. 18 (12), pp. 1495-1515. Date of Electronic Publication: 2026 May 26.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/chemical synthesis , Benzofurans*/pharmacology , Benzofurans*/chemistry , Benzofurans*/chemical synthesis, Reactive Oxygen Species/metabolism ; Nitric Oxide/metabolism ; Neuroglia/drug effects ; Neuroglia/metabolism ; Neuroglia/cytology ; Scopolamine/pharmacology ; Membrane Potential, Mitochondrial/drug effects ; Lipid Peroxidation/drug effects ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Antioxidants/chemical synthesis ; Cell Survival/drug effects ; Animals ; Rats ; Structure-Activity Relationship ; Molecular Docking Simulation ; Cell Line

Diarylheptanoid derivatives with α-synuclein aggregation inhibitory activities from the rhizome of Alpinia officinarum.

Συγγραφείς: Li XY; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., She JF; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Lv QM; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Min L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Zhang SQ; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Shi L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Huang XJ; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Wang Y; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Wang L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China., Song JG; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: songjianguof403@126.com., Che CT; Department of Pharmaceutical Science, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, IL 60612, United States., Ye WC; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: chywc@aliyun.com., Wu ZL; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Jinan University, Guangzhou 510632, PR China; Guangdong-Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: wuzhenlong@hotmail.com.

Πηγή: Fitoterapia [Fitoterapia] 2026 Jun; Vol. 191, pp. 107250. Date of Electronic Publication: 2026 Apr 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Alpinia*/chemistry , Diarylheptanoids*/pharmacology , Diarylheptanoids*/chemistry , Diarylheptanoids*/isolation & purification , alpha-Synuclein*/metabolism , alpha-Synuclein*/antagonists & inhibitors , Rhizome*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/isolation & purification , Plant Extracts*/pharmacology , Plant Extracts*/chemistry, Protein Aggregates/drug effects ; Humans ; Cell Line, Tumor ; Circular Dichroism

Phosphodiesterase 4 as a therapeutic target in Parkinson's disease recent advances.

Συγγραφείς: Zhong J; Department of Clinical Pharmacy, Meizhou People's Hospital (Huangtang Hospital), Meizhou 514031, China. Electronic address: zhongjiahong@mzrmyy.com., Xu J; Department of Pharmacy, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou 362000, China., Xue J; Department of Pharmacy, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515000, China., Qiu Z; Department of Clinical Pharmacy, Meizhou People's Hospital (Huangtang Hospital), Meizhou 514031, China., Chen B; Department of Clinical Pharmacy, Meizhou People's Hospital (Huangtang Hospital), Meizhou 514031, China., Yu X; Department of Pharmacy, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515000, China. Electronic address: xihuiyu2016@163.com., Lin Z; Department of Clinical Pharmacy, Meizhou People's Hospital (Huangtang Hospital), Meizhou 514031, China. Electronic address: linzhuomiao@mzrmyy.com.

Πηγή: Experimental neurology [Exp Neurol] 2026 Jun; Vol. 400, pp. 115680. Date of Electronic Publication: 2026 Feb 09.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Parkinson Disease*/enzymology , Cyclic Nucleotide Phosphodiesterases, Type 4*/metabolism , Phosphodiesterase 4 Inhibitors*/therapeutic use , Phosphodiesterase 4 Inhibitors*/pharmacology , Phosphodiesterase 4 Inhibitors*/administration & dosage , Neuroprotective Agents*/therapeutic use , Neuroprotective Agents*/pharmacology, Cyclic AMP/metabolism ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Humans ; Animals

Hirsutanines H-O, monoterpene indole alkaloids from Uncaria hirsuta with neuroprotective effects.

Συγγραφείς: An N; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Wu LM; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Wu SQ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Huang JL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Huang D; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Yuan FY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Liao YL; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Fan RZ; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Yang XY; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Tang GH; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China., Gan L; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: ganlu36@mail.sysu.edu.cn., Yin S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: yinsh2@mail.sysu.edu.cn.

Πηγή: Phytochemistry [Phytochemistry] 2026 Jun; Vol. 246, pp. 114834. Date of Electronic Publication: 2026 Feb 14.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3700 (Electronic) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neuroprotective Agents*/chemistry , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/isolation & purification , Uncaria*/chemistry , Secologanin Tryptamine Alkaloids*/chemistry , Secologanin Tryptamine Alkaloids*/pharmacology , Secologanin Tryptamine Alkaloids*/isolation & purification , Indole Alkaloids*/chemistry , Indole Alkaloids*/pharmacology , Indole Alkaloids*/isolation & purification , Monoterpenes*/chemistry , Monoterpenes*/pharmacology , Monoterpenes*/isolation & purification, Oxidative Stress/drug effects ; Plant Leaves/chemistry ; Plant Stems/chemistry ; Animals ; PC12 Cells ; Rats ; Molecular Structure ; Structure-Activity Relationship