Innate immunity and the NF-κB pathway control prostate stem cell plasticity, reprogramming and tumor initiation

Authors: Chen Jiang, Yura Song, Sandrine Rorive, Justine Allard, Elisavet Tika, Zahra Zahedi, Christine Dubois, Isabelle Salmon, Alejandro Sifrim, Cédric Blanpain

Source: Nat Cancer
Nature Cancer, 6 (9

Subject Terms: Male, Prostate -- pathology -- immunology -- cytology -- metabolism, PTEN Phosphohydrolase -- genetics -- metabolism, Cell Transformation, Neoplastic -- immunology -- genetics, Stem Cells, Cell Plasticity, PTEN Phosphohydrolase, NF-kappa B, Prostate, Prostatic Neoplasms, Sciences bio-médicales et agricoles, Cellular Reprogramming, Cell Plasticity -- genetics -- immunology, Article, Immunity, Innate, Cellular Reprogramming -- genetics -- immunology, NF-kappa B -- metabolism -- genetics, Mice, Cell Transformation, Neoplastic, Animals, Humans, Prostatic Neoplasms -- pathology -- immunology -- genetics -- metabolism, Signal Transduction

File Description: 1 full-text file(s): application/vnd.openxmlformats-officedocument.wordprocessingml.document

Access URL: https://pubmed.ncbi.nlm.nih.gov/40550901
https://dipot.ulb.ac.be/dspace/bitstream/2013/395592/3/ManuscriptJiangFINAL.docx
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/395592

Identification and Characterization of a Leoligin-Inspired Synthetic Lignan as a TGR5 Agonist

Authors: Perhal, Alexander F., Schwarz, Patrik F., Linder, Thomas, Mihovilovic, Marko D., Schnürch, Michael, Dirsch, Verena M.

Source: J Nat Prod

Subject Terms: 301209 Pharmazie, Immunology, 104015 Organic chemistry, Anti-Inflammatory Agents, 301204 Pharmakognosie, Lignans/pharmacology, Lignans, Assays, Receptors, G-Protein-Coupled, Mice, 301209 Pharmacy, Macrophages/drug effects, SDG 3 - Good Health and Well-being, 104015 Organische Chemie, Receptors, Genetics, Cyclic AMP, Cyclic AMP/metabolism, Animals, Humans, Anti-Inflammatory Agents/pharmacology, 301204 Pharmacognosy, 106052 Cell biology, Molecular Structure, Macrophages, G-Protein-Coupled/agonists, NF-kappa B, RAW 264.7 Cells, HEK293 Cells, SDG 3 – Gesundheit und Wohlergehen, NF-kappa B/metabolism, 106052 Zellbiologie, Agonists

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40146132
https://ucrisportal.univie.ac.at/de/publications/83cac6e1-340b-4524-ae7d-b74039534d64
https://doi.org/10.1021/acs.jnatprod.5c00059
https://hdl.handle.net/11353/10.2157273
https://doi.org/10.1021/acs.jnatprod.5c00059
https://phaidra.univie.ac.at/o:2157273

Effector-host interactome map links type III secretion systems in healthy gut microbiomes to immune modulation

Authors: Young,Veronika, Dohai,Bushra, Halder,Hridi, Fernandez-Macgregor,Jaime, van Heusden, Niels S, Hitch,Thomas C A, Weller,Benjamin, Hyden,Patrick, Saha,Deeya, Pieren, Daan K J, Rittchen, Sonja, Lambourne,Luke, Maseko,Sibusiso B, Lin,Chung-Wen, Tun,Ye Min, Bibus,Jonas, Pletschacher,Luisa, Boujeant,Mégane, Choteau,Sébastien A, Bergogne,Lou, Perrin,Jérémie, Ober,Franziska, Schwehn,Patrick, Rothballer,Simin T, Altmann,Melina, Altmann,Stefan, Strobel,Alexandra, Rothballer,Michael, Tofaute,Marie, Kotlarz,Daniel, Heinig,Matthias, Clavel,Thomas, Calderwood,Michael A, Vidal,Marc, Twizere,Jean-Claude, Vincentelli,Renaud, Krappmann,Daniel, Boes, Marianne, Falter,Claudia, Rattei,Thomas, Brun,Christine, Zanzoni,Andreas, Falter-Braun,Pascal, CTI Boes, Infection & Immunity, Zorg en O&O, Child Health

Subject Terms: Host-Pathogen Interactions/immunology, Type III Secretion Systems/genetics, Bacterial Proteins/metabolism, Gastrointestinal Microbiome/immunology, NF-kappa B/metabolism, Cytokines/metabolism, Journal Article, Humans, Host Microbial Interactions/immunology, Metagenomics, Protein Interaction Maps

File Description: application/pdf

Access URL: https://dspace.library.uu.nl/handle/1874/469307

Sodium butyrate attenuates experimental neonatal necrotizing enterocolitis by suppressing TLR4-mediated NLRP3 inflammasome-dependent pyroptosis

Authors: Gao, Yanan, Yang, Liting, Wu, Hongya, Yao, Qianqian, Wang, Jiaqi, Zheng, Nan

Source: Food & Function. 16:3508-3524

Subject Terms: Pyroptosis/drug effects, Male, Inflammasomes, Intestinal inflammation, Network pharmacologies, Butyric Acid/administration & dosage, NLR Family, Pyrin Domain-Containing 3 Protein/genetics, Inflammasome, Cell Line, Food science, Rats, Sprague-Dawley, Signalling pathways, Tlr4 protein, rat, Enterocolitis, Necrotizing, Signal Transduction/drug effects, Sciences des denrées alimentaires, NLR Family, Pyrin Domain-Containing 3 Protein, Pyroptosis, Inflammasomes/metabolism, Animals, Humans, Enterocolitis, Necrotizing/genetics, Intestinal barriers, Premature infants, Inflammasomes/drug effects, Butyric Acid/pharmacology, NF-kappa B, Enterocolitis, Necrotizing/metabolism, Sodium butyrate, Enterocolitis, Necrotizing/drug therapy, Life sciences, Rats, Toll-Like Receptor 4, Molecular Docking Simulation, Disease Models, Animal, Toll-Like Receptor 4/metabolism, Animals, Newborn, NF-kappa B/metabolism, Rat model, Sciences du vivant, Neonatal rat, Butyric Acid, Nlrp3 protein, rat, NLR Family, Pyrin Domain-Containing 3 Protein/metabolism, Toll-Like Receptor 4/genetics, Protective effects, Food Science, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/40223745
https://hdl.handle.net/2268/332375
https://doi.org/10.1039/d4fo03517h

Human colon stem cells are the predominant epithelial responders to bacterial antigens

Authors: De Vries, Maaike H, Meddens, Claartje A, Hijma, Hemme J, Berrens, Anne-Claire, Jansen, Suze A, Kooiman, Berend A P, Snapper, Scott, Clevers, Hans, Mokry, Michal, Kuijk, Ewart W, Nieuwenhuis, Edward E S

Source: Front Immunol

Subject Terms: Wnt Signaling Pathway/immunology, Antigens, Bacterial, Colon/immunology, Colon, Stem Cells, Epithelial Cells/immunology, Immunology, NF-kappa B, Cell Differentiation, Epithelial Cells, Stem Cells/immunology, Organoids, Enterocytes, NF-kappa B/metabolism, Bacterial/immunology, Humans, Intestinal Mucosa/immunology, Enterocytes/immunology, Antigens, Intestinal Mucosa, Organoids/immunology, Wnt Signaling Pathway

Access URL: https://pubmed.ncbi.nlm.nih.gov/41169355
https://pure.knaw.nl/portal/en/publications/35a40ec8-9f3d-46c1-9258-cd74fcfedbc6
https://doi.org/10.3389/fimmu.2025.1677943
https://hdl.handle.net/20.500.11755/35a40ec8-9f3d-46c1-9258-cd74fcfedbc6

TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signaling

Authors: Matellan, Carlos, Raphael, Bella, Jones, Gareth R, Nwaeziegwe, Mary, Balfe, Sarah, Ohlendieck, Cian M, Bauset, Cristina, Ní Chathail, Méabh B, Kennedy, Ciarán, Doogan, Katie, Winter, Des, Aherne, Carol M, Roche, Helen M, Bain, Calum C, Thorpe, Stephen D, Doherty, Glen, Manresa, Mario C

Source: Matellan, C, Raphael, B, Jones, G R, Nwaeziegwe, M, Balfe, S, Ohlendieck, C M, Bauset, C, Ní Chathail, M B, Kennedy, C, Doogan, K, Winter, D, Aherne, C M, Roche, H M, Bain, C C, Thorpe, S D, Doherty, G & Manresa, M C 2026, 'TWEAK is increased in ulcerative colitis and contributes to fibroblast-mediated monocyte activation via heterologous non-canonical NF-kB/STAT3 signaling', Journal of Crohn's and Colitis, vol. 20, no. 2, jjag012. https://doi.org/10.1093/ecco-jcc/jjag012

Subject Terms: STAT3 Transcription Factor - metabolism, NF-kappa B - metabolism, Monocytes - metabolism, TNFSF12/TWEAK, Coculture Techniques, Fibroblasts - metabolism, Colitis, Ulcerative - metabolism - pathology - genetics, Cytokine TWEAK - metabolism, fibroblasts, Humans, name=SDG 3 - Good Health and Well-being, Phosphorylation, monocytes, Signal Transduction

File Description: application/pdf

Access URL: https://pure.qub.ac.uk/en/publications/4c0f6664-2cdb-4c7c-b687-ea12789e93bd
https://doi.org/10.1093/ecco-jcc/jjag012
https://pureadmin.qub.ac.uk/ws/files/678317434/tweak.pdf

HU308, A Selective Cannabinoid Type-2 Receptor Agonist, Mitigates SARS-COV-2 Spike Protein-Induced Acute Lung Injury in Mice

Authors: Lockett, Janette, Nicholson, Gregory, Richards, Nicholas, Washington, Ryan, Nagre, Nagaraja

Source: Department of Biomedical and Translational Sciences Faculty Publications

Subject Terms: Acute lung injury, Acute lung injury/drug therapy/metabolism/chemically induces, Animals, Bronchoalveolar lavage fluid, Cannabinoid-2 receptor, Cannabinoids, Cannabinoids/pharmacology, Cannabinoid receptor agonists/pharmacology, Covid-19, COVID-19 Drug treatment, Cytokines/metabolism, Disease models, animal, Lung/drug effects/pathology, metabolism, Male, Mice, inbred C57BL, NF-kappa B/Metabolism, Receptor, Cannabinoid, CB2/agonists, SARS-CoV-2, SARS-CoV-2 spike protein subunit 1, Spike glycoprotein, Coronavirus, Chemicals and Drugs, Influenza Humans, Influenza Virus Vaccines

File Description: application/pdf

Relation: https://digitalcommons.odu.edu/biomedical_pubs/28; https://digitalcommons.odu.edu/context/biomedical_pubs/article/1027/viewcontent/Lockett_2026_HU308ASelectiveCannabinoidType2OCRed.pdf; https://digitalcommons.odu.edu/context/biomedical_pubs/article/1027/filename/1/type/additional/viewcontent/408_2026_870_MOESM1_ESM.docx

Availability: https://digitalcommons.odu.edu/biomedical_pubs/28
https://doi.org/10.1007/s00408-026-00870-6
https://digitalcommons.odu.edu/context/biomedical_pubs/article/1027/viewcontent/Lockett_2026_HU308ASelectiveCannabinoidType2OCRed.pdf
https://digitalcommons.odu.edu/context/biomedical_pubs/article/1027/filename/1/type/additional/viewcontent/408_2026_870_MOESM1_ESM.docx

Inflammatory and epigenetic alterations associated with attention deficits in adolescents with cocaine base paste addiction.

Authors: Sonzogni, Silvina V, de la Fuente, Laura A, Mimura, Camila, Aragón Daud, Agustina, Vignaga, Sofía Schurmann, Vota, Daiana, Manes, Facundo, Cetkovich, Marcelo, Torralva, Teresa, Ibañez, Agustin, Cánepa, Eduardo T

Source: Journal of Psychiatric Research, 192, 227 - 236 (2026-01)

Subject Terms: Addiction, Attention, DNMT1, DNMT3A, Global methylation, DNA (Cytosine-5-)-Methyltransferase 1, DNMT1 protein, human, DNA Methyltransferase 3A, DNA (Cytosine-5-)-Methyltransferases, DNMT3A protein, Cocaine, NF-kappa B, Tumor Necrosis Factor-alpha, Humans, Adolescent, Male, Female, DNA (Cytosine-5-)-Methyltransferase 1/metabolism, DNA Methylation, DNA (Cytosine-5-)-Methyltransferases/metabolism, Pilot Projects, NF-kappa B/metabolism, Tumor Necrosis Factor-alpha/metabolism, Epigenesis, Genetic, Cocaine-Related Disorders/complications, Cocaine-Related Disorders/genetics, Cocaine-Related Disorders/metabolism, Inflammation/metabolism

Relation: https://api.elsevier.com/content/article/PII:S0022395625006545?httpAccept=text/xml; urn:issn:0022-3956; urn:issn:1879-1379; https://orbi.uliege.be/handle/2268/343746; info:hdl:2268/343746; info:pmid:41172928

Availability: https://orbi.uliege.be/handle/2268/343746
https://orbi.uliege.be/bitstream/2268/343746/1/1-s2.0-S0022395625006545-main.pdf
https://doi.org/10.1016/j.jpsychires.2025.10.046

Discovery of the Alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro

Authors: Crudo, Francesco, Partsch, Vanessa, Braga, Dennis, Blažević, Ruzica, Rollinger, Judith, Varga, Elisabeth, Marko, Doris

Source: Arch Toxicol

Subject Terms: Mycotoxins Toxicity, THP-1 Cells, Biologics, Monocytes, Estrogen Antagonists Toxicity, Lactones, SDG 3 - Good Health and Well-being, Immunosuppressive Agents Toxicity, Tandem Mass Spectrometry, Benz(a)Anthracenes, Benz(a) Anthracenes Toxicity, Humans, 301211 Toxicology, Food contaminants, Lactones Toxicity, NF-kappa B Metabolism, Estrogen Antagonists, NF-kappa B, Alternaria, Mycotoxins, In vitro toxicity, Alternaria mycotoxins, 301211 Toxikologie, SDG 3 – Gesundheit und Wohlergehen, Chemical mixture, chemical mixtures, food contaminants, Estrogen Antagonists Pharmacology, Immunosuppressive Agents

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/39358629
https://hdl.handle.net/11353/10.2137939
https://phaidra.univie.ac.at/o:2137939
https://doi.org/10.1007/s00204-024-03877-1

Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes

Authors: Alraies, Zahraa, Rivera, Claudia, Delgado, Maria-Graciela, Sanséau, Doriane, Maurin, Mathieu, Amadio, Roberto, Maria Piperno, Giulia, Dunsmore, Garett, Yatim, Aline, Lacerda Mariano, Livia, Kniazeva, Anna, Calmettes, Vincent, Sáez, Pablo, Williart, Alice, Popard, Henri, Gratia, Matthieu, Lamiable, Olivier, Moreau, Aurélie, Fusilier, Zoé, Crestey, Lou, Albaud, Benoit, Legoix, Patricia, Dejean, Anne, Le Dorze, Anne-Louise, Nakano, Hideki, Cook, Donald, Lawrence, Toby, Manel, Nicolas, Benvenuti, Federica, Ginhoux, Florent, Moreau, Hélène, P F Nader, Guilherme, Piel, Matthieu, Lennon-Duménil, Ana-Maria, P. F. Nader, Guilherme

Contributors: KERANDEL-DION, Céline, Immunité et cancer (U932), Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM), Instituto de Ciencias de la Atmósfera y Cambio Climático, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), International Centre for Genetic Engineering and Biotechnology Trieste, Italy (ICGEB), Immunologie anti-tumorale et immunothérapie des cancers (ITIC), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université Paris Dauphine-PSL, Université Paris Sciences et Lettres (PSL), Université Paris Cité (UPCité), Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Curie Paris, Institut Pierre-Gilles de Gennes pour la Microfluidique (IPGG), École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris Sciences et Lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris Sciences et Lettres (PSL)-Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche de l'Institut Curie Paris, Malaghan Institute of Medical Research Wellington, New Zealand, Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Team 1 : Mononuclear phagocytes, Immunopathology, Immunovirology (Team 1 - U1064 Inserm - CR2TI), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Plateforme ICGex NGS Curie, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Institute of Environmental Health Sciences Durham, NC, USA (NIEHS-NIH), National Institutes of Health Bethesda, MD, USA (NIH), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Shanghai Jiao Tong University School of Medicine, Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Biologie Cellulaire et Cancer, Institut Curie Paris -Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Children’s Hospital of Philadelphia (CHOP), Perelman School of Medicine, University of Pennsylvania, SMC202006012351/Fondation pour la Recherche Médicale (Foundation for Medical Research in France)RGP0032-2022/Human Frontier Science Program (HFSP), ANR-20-CE15-0023,InfEx,Propriétés physiques de la matrice extracellulaire et impact sur les réponses immunitaires contre les infections(2020), ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010), European Project: 9496249(1994)

Source: Nat Immunol
Nature Immunology

Subject Terms: 0301 basic medicine, Receptors, CCR7, Knockout, [SDV]Life Sciences [q-bio], MESH: Cell Movement / immunology, Inbred C57BL, Article, Actin-Related Protein 2-3 Complex, Mice, 03 medical and health sciences, Cell Movement, MESH: Receptors, MESH: Cell Shape, MESH: Lymph Nodes / immunology, Animals, Homeostasis, MESH: Animals, MESH: NF-kappa B / metabolism, MESH: Dendritic Cells / metabolism, MESH: Mice, Cell Shape, Mice, Knockout, 0303 health sciences, MESH: Actin-Related Protein 2-3 Complex / metabolism, MESH: Signal Transduction / immunology, NF-kappa B, Dendritic Cells, CCR7 / metabolism, MESH: I-kappa B Kinase / metabolism, I-kappa B Kinase, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, MESH: Homeostasis, MESH: Lymph Nodes / cytology, Lymph Nodes, MESH: Dendritic Cells / immunology, Signal Transduction

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38834865

The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

Authors: Joan Kyula-Currie, Victoria Roulstone, James Wright, Francesca Butera, Arnaud Legrand, Richard Elliott, Martin McLaughlin, Galabina Bozhanova, Dragomir Krastev, Stephen Pettitt, Tencho Tenev, Magnus Dillon, Shane Foo, Emmanuel C. Patin, Victoria Jennings, Charleen Chan Wah Hak, Elizabeth Appleton, Amarin Wongariyapak, Malin Pedersen, Antonio Rullan, Jyoti Choudhary, Chris Bakal, Pascal Meier, Christopher J. Lord, Alan Melcher, Kevin J. Harrington

Source: Nat Commun

Subject Terms: Poly (ADP-Ribose) Polymerase-1/metabolism, Poly (ADP-Ribose) Polymerase-1, Apoptosis, Poly(ADP-ribose) Polymerase Inhibitors, Reoviridae, Article, Cell Line, Mice, DEAD Box Protein 58/metabolism, Cell Line, Tumor, Neoplasms, Neoplasms/therapy, Animals, Humans, Oncolytic Virotherapy, Tumor, Animal, Apoptosis/drug effects, NF-kappa B, Drug Synergism, Poly(ADP-ribose) Polymerase Inhibitors/pharmacology, Disease Models, Animal, Oncolytic Viruses, Oncolytic Virotherapy/methods, Disease Models, NF-kappa B/metabolism, Phthalazines, DEAD Box Protein 58, Female, Phthalazines/pharmacology

Access URL: https://pubmed.ncbi.nlm.nih.gov/40628717
https://eprints.whiterose.ac.uk/id/eprint/230921/

Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

Authors: Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C. Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Dominik Schmidt, Viktor Fetsch, Alexander Zähringer, Henrike Salié, Dimitrios Athanassopoulos, Lukas M. Braun, Nora R. Javorniczky, Jenny N. H. G. Ho, Katrin Kierdorf, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian Capitini, Terry J. Fry, Thomas Blank, Bruce R. Blazar, Eva Wagner, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp T. Meyer, Joachim Brumberg, Simon Völkl, Andreas Mackensen, Roland Coras, Michael von Bergwelt-Baildon, Nathalie L. Albert, Laura M. Bartos, Matthias Brendel, Adrien Holzgreve, Matthias Mack, Melanie Boerries, Crystal L. Mackall, Justus Duyster, Philipp Henneke, Josef Priller, Natalie Köhler, Felix Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser

Source: Nature cancer 5(8), 1227-1249 (2024). doi:10.1038/s43018-024-00764-7
Nature Cancer

Subject Terms: Antigens, CD19: immunology, cell-associated neurotoxicity, Lymphoma, B-Cell, Cd19, Tak1, T-Lymphocytes, Antigens, CD19, Expression, Neurotoxicity Syndromes: etiology, Immunotherapy, Adoptive, p38 Mitogen-Activated Protein Kinases, MAP Kinase Kinase Kinase 7, Mice, Microglia: metabolism, p38 Mitogen-Activated Protein Kinases: metabolism, Animals, Humans, 1306 Cancer Research, Lymphoma, B-Cell: immunology, Alpha, Receptors, Chimeric Antigen, T-Lymphocytes: immunology, MAP Kinase Kinase Kinases: metabolism, Peripheral Benzodiazepine-Receptors, Translocator Protein, NF-kappa B, MAP Kinase Kinase Kinases, 3. Good health, MAP kinase kinase kinase 7, Human Brain, Receptors, Chimeric Antigen: immunology, NF-kappa B: metabolism, Versus-Host-Disease, 2730 Oncology, Neurotoxicity Syndromes, Female, Microglia, Neurotoxicity Syndromes: immunology, Cytokine Release Syndrome, MAP Kinase Kinase Kinases: genetics, Microglia: immunology, Immunotherapy, Adoptive: methods, Chimeric Antigen Receptor, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/38741011
https://espace.library.uq.edu.au/view/UQ:7fe0375
https://api.library.uq.edu.au/view/UQ:7fe0375
https://pub.dzne.de/record/271874

Noncanonical NF-κB signaling in dendritic cells is required for ATP-driven indoleamine 2,3-dioxygenase 1 induction through P2Y11 receptor

Authors: Ocadlikova D., Fiordi B., Trabanelli S., Salvestrini V., Ciciarello M., Forte D., Campazzi E., Vitali L., Cipollitta S. C., Pegoraro A., Jandus C., Di Virgilio F., Adinolfi E., Cavo M., Curti A.

Source: Journal of leukocyte biology, vol. 117, no. 4

Subject Terms: Adenosine Triphosphate / metabolism, T-Lymphocytes, Regulatory / immunology, 616.07, Indoleamine-2, 3-dioxygenase 1, ATP, dendritic cell, immune tolerance, indoleamine-2, tumor, T-Lymphocytes, Regulatory, NF-kappa B / metabolism, NF-kappa B / immunology, Dendritic Cells/metabolism, Dendritic Cells/immunology, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism, Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics, Adenosine Triphosphate/metabolism, Signal Transduction, NF-kappa B/metabolism, NF-kappa B/immunology, Receptors, Purinergic P2/metabolism, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/metabolism, Receptors, Purinergic P2 / metabolism, Adenosine Triphosphate, Indoleamine-Pyrrole 2,3,-Dioxygenase / genetics, Dendritic Cells / immunology, Indoleamine-Pyrrole 2,3,-Dioxygenase, Tumor, Receptors, Purinergic P2, Immune tolerance, NF-kappa B, T-Lymphocytes, Regulatory / metabolism, Dendritic Cells, Dendritic Cells / metabolism, Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism, Dendritic cell

File Description: application/pdf; application/msword

Access URL: https://pubmed.ncbi.nlm.nih.gov/39899472
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_491A6B46FE349
https://serval.unil.ch/notice/serval:BIB_491A6B46FE34
https://serval.unil.ch/resource/serval:BIB_491A6B46FE34.P001/REF.pdf

Bosutinib stimulates macrophage survival, phagocytosis and intracellular killing of bacteria

Authors: Ronni A. G. da Silva, Claudia J. Stocks, Guangan Hu, Kimberly A. Kline, Jianzhu Chen

Source: ACS Infect Dis

Subject Terms: Cell Survival / drug effects, antibiotic resistance, Antibiotic resistance, Cell Survival, Wound infection, Macrophages / drug effects, immunomodulation, NF-kappa B / metabolism, Immunomodulation, Aniline Compounds / pharmacology, Mice, Phagocytosis, Nitriles, Enterococcus faecalis, Animals, Humans, Enterococcus faecalis / drug effects, Gram-Positive Bacterial Infections, Aniline Compounds, Macrophages, NF-kappa B, Gram-Positive Bacterial Infections / drug therapy, Reactive Oxygen Species / metabolism, phagocytosis, 2725 Infectious Diseases, Anti-Bacterial Agents / pharmacology, macrophages, Src kinases targeting, Anti-Bacterial Agents, 3. Good health, Mice, Inbred C57BL, Quinolines, Nitriles / pharmacology, wound infection, Phagocytosis / drug effects, Reactive Oxygen Species, Quinolines / pharmacology

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/38602352
https://api.library.uq.edu.au/view/UQ:edd5faa
https://espace.library.uq.edu.au/view/UQ:edd5faa

Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1

Authors: Maximilian Nickenig, Matthew S J Mangan, Hye Eun Lee, Konstantinos Symeonidis, Antonia Henne, Romina Kaiser, Eike Geißmar, Hendrikus Garritsen, Zeinab Abdullah, Karsten Hiller, Eicke Latz, Mario A Lauterbach

Source: The journal of immunology 212(1), 7-11 (2024). doi:10.4049/jimmunol.2200835

Subject Terms: Macrophages: metabolism, Macrophages, NF-kappa B, Membrane Proteins, ATP Citrate (pro-S)-Lyase: metabolism, TBK1 protein, human, DNA, Protein Serine-Threonine Kinases: metabolism, Protein Serine-Threonine Kinases, Nucleotidyltransferases, Membrane Proteins: metabolism, Interferon Regulatory Factor-3: metabolism, STING Protein, Nucleotidyltransferases: metabolism, STING1 protein, human, NF-kappa B: metabolism, ATP Citrate (pro-S)-Lyase, Humans, Interferon Regulatory Factor-3

Access URL: https://pubmed.ncbi.nlm.nih.gov/38038390
https://pub.dzne.de/record/266754

Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype

Authors: Maximilian Reck, David P. Baird, Stefan Veizades, Callum Sutherland, Rachel M. B. Bell, Heeyoun Hur, Carolynn Cairns, Piotr P. Janas, Ross Campbell, Andy Nam, Wei Yang, Nathan Schurman, Claire Williams, Eoin O’Sullivan, Meryam Beniazza, Andrea Corsinotti, Christopher Bellamy, Jeremy Hughes, Alexander Laird, Laura Denby, Tamir Chandra, David A. Ferenbach, Bryan R. Conway

Source: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-23 (2025)
Reck, M, Baird, D P, Veizades, S, Sutherland, C, Bell, R M B, Hur, H, Cairns, C, Janas, P P, Campbell, R, Nam, A, Yang, W, Schurman, N, Williams, C, O'Sullivan, E, Beniazza, M, Corsinotti, A, Bellamy, C, Hughes, J, Laird, A, Denby, L, Chandra, T, Ferenbach, D A & Conway, B R 2025, 'Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype', Nature Communications, vol. 16, 4745. https://doi.org/10.1038/s41467-025-59997-4, https://doi.org/10.1038/s41467-025-59997-4

Subject Terms: Male, Vascular Cell Adhesion Molecule-1/metabolism, Science, Vascular Cell Adhesion Molecule-1, 32 Biomedical and Clinical Sciences, Injury, Ligand, Article, Kidney Tubules, Proximal, Mice, Inflammation/genetics, Humans, Animals, Hepatitis A Virus Cellular Receptor 1, Renal Insufficiency, Chronic, Inflammation, NF-kappa B, Epithelial Cells, Intercellular Adhesion Molecule-1/metabolism, Intercellular Adhesion Molecule-1, Fibrosis, Renal Insufficiency, Chronic/pathology, Epithelial Cells/metabolism, Transcription Factor AP-1, Mice, Inbred C57BL, 3208 Medical physiology, Disease Models, Animal, Phenotype, Kidney Tubules, Proximal/pathology, NF-kappa B/metabolism, Female, Atlas, Hepatitis A Virus Cellular Receptor 1/metabolism, Transcription Factor AP-1/metabolism

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40399382
https://doaj.org/article/b9a4b8406f164946a8482841d8dfc504
https://api.library.uq.edu.au/view/UQ:b1cc024
https://espace.library.uq.edu.au/view/UQ:b1cc024
https://hdl.handle.net/20.500.11820/c70a5632-eacb-4b99-8882-66a88e74fa3a
https://www.research.ed.ac.uk/en/publications/c70a5632-eacb-4b99-8882-66a88e74fa3a
https://doi.org/10.1038/s41467-025-59997-4
https://www.pure.ed.ac.uk/ws/files/528987978/Multiomic_analysis_of_human_kidney_disease_identifies_a_tractable_inflammatory_and_pro-fibrotic_tubular_cell_phenotype.pdf

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Authors: Liang,Xiuming, Gupta,Dhanu, Xie,Junhua, Van Wonterghem,Elien, Van Hoecke,Lien, Hean,Justin, Niu,Zheyu, Ghaeidamini,Marziyeh, Wiklander,Oscar P B, Zheng,Wenyi, Wiklander,Rim Jawad, He, Rui, Mamand,Doste R, Bost,Jeremy, Zhou,Guannan, Zhou,Houze, Roudi,Samantha, Estupiñán,H Yesid, Rädler,Julia, Zickler,Antje M, Görgens,André, Hou,Vicky W Q, Slovak,Radka, Hagey,Daniel W, de Jong, Olivier G, Uy,Aileen Geobee, Zong,Yuanyuan, Mäger,Imre, Perez,Carla Martin, Roberts,Thomas C, Carter,Dave, Vader, Pieter, Esbjörner,Elin K, de Fougerolles,Antonin, Wood,Matthew J A, Vandenbroucke,Roosmarijn E, Nordin,Joel Z, El Andaloussi,Samir, CDL Nanomedicine, CDL Cluster Onderzoek en Onderwijs, Circulatory Health

Subject Terms: Gene Editing/methods, Mice, HEK293 Cells, Inflammation/chemically induced, CRISPR-Associated Protein 9/metabolism, Integrases/genetics, NF-kappa B/metabolism, Drug Delivery Systems/methods, Journal Article, Animals, Humans, Extracellular Vesicles/metabolism, CRISPR-Cas Systems

File Description: text/plain

Access URL: https://dspace.library.uu.nl/handle/1874/465956

Small molecule inhibitors of hnRNPA2B1–RNA interactions reveal a predictable sorting of RNA subsets into extracellular vesicles

Authors: Corsi, Jessica, Semnani, Pouriya Sharbatian, Peroni, Daniele, Belli, Romina, Morelli, Alessia, Lassandro, Michelangelo, Sidarovich, Viktoryia, Adami, Valentina, Valentini, Chiara, Cavallerio, Paolo, Grosskreutz, Julian, Fabbiano, Fabrizio, Grossmann, Dajana, Hermann, Andreas, Tell, Gianluca, Basso, Manuela, D’Agostino, Vito Giuseppe

Source: Nucleic Acids Res
Nucleic acids research 53(5), gkaf176 (2025). doi:10.1093/nar/gkaf176

Subject Terms: Proteomics, Proteomics: methods, Extracellular Vesicles: genetics, Extracellular Vesicles: drug effects, Heterogeneous-Nuclear Ribonucleoprotein Group A-B: antagonists & inhibitors, Small Molecule Libraries, Extracellular Vesicles, Heterogeneous-Nuclear Ribonucleoprotein Group A-B: metabolism, RNA: metabolism, Heterogeneous-Nuclear Ribonucleoprotein Group A-B, RNA and RNA-protein complexes, Humans, hnRNP A2, Protein Binding: drug effects, Small Molecule Libraries: pharmacology, RNA-Binding Proteins: metabolism, NF-kappa B, RNA-Binding Proteins, Extracellular Vesicles: metabolism, Heterogeneous-Nuclear Ribonucleoprotein Group A-B: genetics, HEK293 Cells, NF-kappa B: metabolism, RNA, RNA: genetics, Protein Binding

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40103230
https://pub.dzne.de/record/277552

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans

Authors: Riller, Quentin, Sorin, Boris, Courteille, Charline, Ho-Nhat, Duong, Le Voyer, Tom, Debray, Jean-Christophe, Stolzenberg, Marie-Claude, Schmutz, Muriel, Pellé, Olivier, Becquard, Thomas, Rodrigo Riestra, María, Berteloot, Laureline, Migaud, Mélanie, Delage, Laure, Jeanpierre, Marie, Boussard, Charlotte, Brunaud, Camille, Magérus, Aude, Bretot, Charles, Michel, Victor, Roux, Camille, Picard, Capucine, Masson, Cécile, Bole-Feysot, Christine, Cagnard, Nicolas, Corneau, Aurélien, Meyts, Isabelle, Baud, Véronique, Casanova, Jean-Laurent, Fischer, Alain, Dejardin, Emmanuel, Puel, Anne, Boulanger, Cécile, Neven, Bénédicte, Rieux-Laucat, Frédéric

Contributors: LORENZO, Lazaro

Source: J Exp Med

Subject Terms: NFKB2, Immunology, NF-KAPPA-B, BETA, Genetics & genetic processes, Research & Experimental Medicine, Agammaglobulinemia/immunology, MICE LACKING, Article, ACTIVATION, PATHWAY, Génétique & processus génétiques, Protein Domains, Agammaglobulinemia, Immunologic Deficiency Syndromes/immunology, Humans, Agammaglobulinemia/genetics, 11 Medical and Health Sciences, GENE-EXPRESSION, Science & Technology, ERN-RITA, 42 Health sciences, I-kappa B Kinase/metabolism, NF-kappa B, Immunologic Deficiency Syndromes, NF-KAPPA-B2, I-kappa B Kinase/genetics, GERMLINE MUTATIONS, 32 Biomedical and clinical sciences, Life sciences, I-kappa B Kinase, [SDV] Life Sciences [q-bio], Jeffrey Modell Foundation, HEK293 Cells, CHUK protein, human, Medicine, Research & Experimental, NF-kappa B/metabolism, Mutation, Sciences du vivant, T-CELLS, Immunologic Deficiency Syndromes/genetics, Female, Life Sciences & Biomedicine, Signal Transduction

Access URL: https://pubmed.ncbi.nlm.nih.gov/39812688
https://pmc.ncbi.nlm.nih.gov/articles/PMC11734625/
https://doi.org/10.1084/jem.20240843
https://pubmed.ncbi.nlm.nih.gov/39812688/
https://hdl.handle.net/2268/327168
https://doi.org/10.1084/jem.20240843
https://hal.science/hal-05080410v1
https://doi.org/10.1084/jem.20240843

Pellino-1 promotes intrinsic activation of skin-resident IL-17A–producing T cells in psoriasis

Authors: Sung Hee Kim, Jongwook Oh, Won Seok Roh, Jeyun Park, Kyung Bae Chung, Gwang Hee Lee, Youn Sook Lee, Jong Hoon Kim, Heung Kyu Lee, Ho Lee, Chang-Ook Park, Do-Young Kim, Min-Geol Lee, Tae-Gyun Kim

Contributors: Sung Hee Kim, Jongwook Oh, Won Seok Roh, Jeyun Park, Kyung Bae Chung, Gwang Hee Lee, Youn Sook Lee, Jong Hoon Kim, Heung Kyu Lee, Ho Lee, Chang-Ook Park, Do-Young Kim, Min-Geol Lee, Tae-Gyun Kim, Kim, Do Young

Source: Journal of Allergy and Clinical Immunology. 151:1317-1328

Subject Terms: 0301 basic medicine, Ubiquitin-Protein Ligases, Dermatitis, Nuclear Proteins / genetics, NF-κB, single-cell RNA sequencing, NF-kappa B / metabolism, Mice, 03 medical and health sciences, Humans, Animals, Psoriasis, Ubiquitin-Protein Ligases / genetics, Interleukin-17A, Skin, 0303 health sciences, Animal, Pellino-1, Nuclear Proteins / metabolism, Interleukin-17, NF-kappa B, Nuclear Proteins, psoriasis, skin-resident T cells, 3. Good health, Disease Models, Animal, Disease Models

Access URL: https://pubmed.ncbi.nlm.nih.gov/36646143