Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification

Συγγραφείς: Fallegger, Robin, Gomez-Ochoa, Sergio A., Boys, Charlotte, Ramirez Flores, Ricardo Omar, Tanevski, Jovan, Pashos, Evanthia, Feliers, Denis, Piper, Mary, Schaub, Jennifer A., Zhou, Zixiang, Mao, Weiguang, Chen, Xi, Sealfon, Rachel S. G., Menon, Rajasree, Nair, Viji, Eddy, Sean, Alakwaa, Fadhl M., Pyle, Laura, Choi, Ye Ji, Bjornstad, Petter, Alpers, Charles E., Bitzer, Markus, Bomback, Andrew S., Caramori, M. Luiza, Demeke, Dawit, Fogo, Agnes B., Herlitz, Leal C., Kiryluk, Krzysztof, Lash, James P., Murugan, Raghavan, O'Toole, John F., Palevsky, Paul M., Parikh, Chirag R., Rosas, Sylvia E., Rosenberg, Avi Z., Sedor, John R., Vazquez, Miguel A., Waikar, Sushrut S., Wilson, F. Perry, Hodgin, Jeffrey B., Barisoni, Laura, Himmelfarb, Jonathan, Jain, Sanjay, Ju, Wenjun, Troyanskaya, Olga G., Kretzler, Matthias, Eadon, Michael T., Saez-Rodriguez, Julio

Συνεισφορές: Medicine, School of Medicine

Πηγή: PMC

Θεματικοί όροι: Acute kidney injury, Chronic kidney disease, Single cell transcriptomics, Multi-cellular programs

Περιγραφή αρχείου: application/pdf

Relation: https://hdl.handle.net/1805/55148

Διαθεσιμότητα: https://hdl.handle.net/1805/55148

Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.

Συγγραφείς: Fallegger R; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Gomez-Ochoa SA; Heidelberg University Hospital, Department of General Internal Medicine and Psychosomatics, Heidelberg, Germany., Boys C; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Flores ROR; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, U.K., Tanevski J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Pashos E; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, United States., Feliers D; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, United States., Piper M; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, United States., Schaub JA; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Zhou Z; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA., Mao W; Princeton Precision Health, Princeton University, Princeton, NJ 08544, USA., Chen X; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA., Sealfon RSG; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA., Menon R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Nair V; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Eddy S; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Alakwaa FM; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Pyle L; University of Washington Medicine Diabetes Institute, Seattle, WA 98109, USA., Choi YJ; University of Washington Medicine Diabetes Institute, Seattle, WA 98109, USA., Bjornstad P; University of Washington Medicine Diabetes Institute and Seattle Children's Research Institute, Seattle, WA 98109, USA., Alpers CE; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195., Bitzer M; University of Michigan., Bomback AS; Division of Nephrology, Columbia University Irving Medical Center, New York, NY, USA., Caramori ML; Department of Endocrinology and Metabolism, Cleveland Clinic Foundation, Cleveland, OH, USA.; Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN, USA., Demeke D; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Fogo AB; Department. Of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Herlitz LC; Cleveland Clinic., Kiryluk K; Department of Medicine, Division of Nephrology, Vagelos College of Physicians & Surgeons, Columbia University., Lash JP; Department of Medicine, University of Illinois Chicago, Chicago, Illinois., Murugan R; University of Pittsburgh., O'Toole JF; Department of Kidney Medicine, Medical Specialties Institute, Cleveland Clinic & Department of Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH., Palevsky PM; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Parikh CR; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, US., Rosas SE; Kidney and Hypertension Unit, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA., Rosenberg AZ; Department of Pathology, Johns Hopkins University School of Medicine Baltimore, MD, USA., Sedor JR; Department of Kidney Medicine, Medical Specialties Institute, Cleveland Clinic & Department of Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH., Vazquez MA; Nephrology Division, University of Texas Southwestern Medical Center., Waikar SS; Section of Nephrology, Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine., Wilson FP; Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT., Hodgin JB; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Barisoni L; Department of Pathology, Division of AI & Computational Pathology, Department of Medicine, Division of Nephrology, Duke University, Durham, NC, USA., Himmelfarb J; Barbara T. Murphy Division of Nephrology, Samuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai., Jain S; Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Kidney Translational Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Ju W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Troyanskaya OG; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.; Princeton Precision Health, Princeton University, Princeton, NJ 08544, USA.; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA.; Department of Computer Science, Princeton University, Princeton, NJ 08544, USA., Kretzler M; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Co-senior authors: Matthias Kretzler, Michael T. Eadon, Julio Saez-Rodriguez., Eadon MT; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Co-senior authors: Matthias Kretzler, Michael T. Eadon, Julio Saez-Rodriguez., Saez-Rodriguez J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, U.K.; Co-senior authors: Matthias Kretzler, Michael T. Eadon, Julio Saez-Rodriguez.

Πηγή: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 06. Date of Electronic Publication: 2026 Mar 06.

Τύπος έκδοσης: Journal Article; Preprint

Στοιχεία περιοδικού: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE