Evaluation of correlated studies using liquid cell and cryo‐transmission electron microscopy: Hydration of calcium sulphate and the phase transformation pathways of bassanite to gypsum

Συγγραφείς: Ilett, M, Freeman, HM, Aslam, Z, Galloway, JM, Klebl, DP, Muench, SP, McPherson, IJ, Cespedes, O, Kim, Y-Y, Meldrum, FC, Yeandel, SR, Freeman, CL, Harding, JH, Brydson, RMD

Πηγή: J Microsc
Journal of Microscopy

Θεματικοί όροι: QH, TN, Themed Issue Articles, cryogenic TEM, 02 engineering and technology, Calcium Sulfate, 01 natural sciences, 0104 chemical sciences, Microscopy, Electron, Transmission, calcium sulphate, liquid phase TEM, crystallisation, QD, Crystallization, 0210 nano-technology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35348205
https://eprints.whiterose.ac.uk/185528/1/CaSO4LCTEM_FINAL.pdf
https://eprints.whiterose.ac.uk/id/eprint/185528/
https://eprints.whiterose.ac.uk/id/eprint/185305/

Towards sub-millisecond cryo-EM grid preparation

Συγγραφείς: Klebl, DP, Kay, RW, Sobott, F, Kapur, N, Muench, SP

Πηγή: Faraday Discuss

Θεματικοί όροι: 0301 basic medicine, Chemistry, 0303 health sciences, 03 medical and health sciences, Cryoelectron Microscopy, Water, Specimen Handling

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35920384
https://eprints.whiterose.ac.uk/189949/1/d2fd00079b.pdf
https://eprints.whiterose.ac.uk/id/eprint/189949/

Structural basis for the functional properties of the P2X7 receptor for extracellular ATP

Συγγραφείς: Jiang, L-H, Caseley, EA, Muench, SP, Roger, S

Πηγή: Purinergic Signal

Θεματικοί όροι: Antagonism, 0301 basic medicine, Ion permeation, 0303 health sciences, Binding Sites, Agonist binding, Large pore formation, Extracellular Fluid, Review Article, Protein Structure, Secondary, 03 medical and health sciences, Adenosine Triphosphate, Animals, Humans, Receptor activation, Amino Acid Sequence, Receptors, Purinergic P2X7

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://link.springer.com/content/pdf/10.1007/s11302-021-09790-x.pdf
https://pubmed.ncbi.nlm.nih.gov/33987781
https://eprints.whiterose.ac.uk/173622/6/Jiang2021_Article_StructuralBasisForTheFunctiona.pdf
https://eprints.whiterose.ac.uk/id/eprint/173622/

Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site‐directed mutagenesis

Συγγραφείς: Caseley, EA, Muench, SP, Jiang, L-H

Πηγή: Proteins: Structure, Function, and Bioinformatics. 90:619-624

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Patch-Clamp Techniques, P2X7R, structural modeling, structure–function relationships, molecular docking, patch-clamp recording, 3. Good health, Rats, Molecular Docking Simulation, 03 medical and health sciences, Adenosine Triphosphate, Mutation, Mutagenesis, Site-Directed, Animals, Humans, Tyrosine, Amino Acid Sequence, Receptors, Purinergic P2X7, site-directed mutagenesis, Protein Binding

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/34622987
https://eprints.whiterose.ac.uk/id/eprint/178808/

Detergent-Free Functionalization of Hybrid Vesicles with Membrane Proteins Using SMALPs

Συγγραφείς: Catania, R, Machin, J, Rappolt, M, Muench, SP, Beales, PA, Jeuken, LJC

Πηγή: Macromolecules

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6124b75e1d1cc2c6b2cb1eb1/original/detergent-free-functionalisation-of-hybrid-vesicles-with-membrane-proteins-using-smal-ps.pdf
https://pubmed.ncbi.nlm.nih.gov/35571225
https://eprints.whiterose.ac.uk/186081/5/acs.macromol.2c00326.pdf
https://hdl.handle.net/1887/3443698
https://eprints.whiterose.ac.uk/id/eprint/186081/

Targeting KNa1.1 channels in KCNT1-associated epilepsy

Συγγραφείς: Cole, BA, Clapcote, SJ, Muench, SP, Lippiat, JD

Πηγή: Trends in Pharmacological Sciences. 42:700-713

Θεματικοί όροι: 0301 basic medicine, (AD)SHE, Epilepsy, KCNT1, Nerve Tissue Proteins, Potassium Channels, Sodium-Activated, Quinidine, 3. Good health, EIMFS, 03 medical and health sciences, KNa1.1, Mutation, epilepsy, Animals, Humans, potassium channel

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/34074526
https://eprints.whiterose.ac.uk/174791/1/Cole2021_TiPS.pdf
https://eprints.whiterose.ac.uk/id/eprint/174791/

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors

Συγγραφείς: Caseley, EA, Muench, SP, Jiang, L-H

Πηγή: Purinergic Signal

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Brief Communication, Rats, 03 medical and health sciences, HEK293 Cells, Agonist-induced currents, Whole-cell recording, P2X7 receptor, Mutation, Animals, Humans, Species difference, Receptors, Purinergic P2X7

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://link.springer.com/content/pdf/10.1007/s11302-020-09730-1.pdf
https://pubmed.ncbi.nlm.nih.gov/33029714
https://eprints.whiterose.ac.uk/id/eprint/165389/

Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels

Συγγραφείς: Bauer, CC, Minard, A, Pickles, IB, Simmons, KJ, Chuntharpursat-Bon, E, Burnham, MP, Kapur, N, Beech, DJ, Muench, SP, Wright, MH, Warriner, SL, Bon, RS

Πηγή: RSC Chem Biol

Θεματικοί όροι: 0301 basic medicine, Chemistry, 0303 health sciences, 03 medical and health sciences, 3. Good health

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubs.rsc.org/en/content/articlepdf/2020/cb/d0cb00126k
https://pubmed.ncbi.nlm.nih.gov/41324141
https://eprints.whiterose.ac.uk/165902/1/d0cb00126k.pdf
https://eprints.whiterose.ac.uk/id/eprint/165902/

A 2.2Å cryoEM structure of a quinol-dependent Nitric Oxide Reductase shows close similarity to the respiratory quinol oxidase family

Συγγραφείς: Flynn, AJ, Antonyuk, SV, Eady, RR, Muench, SP, Hasnain, SS

Σύνδεσμος πρόσβασης: https://eprints.whiterose.ac.uk/id/eprint/200060/

Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications

Συγγραφείς: Yin, Y, Wei, L, Caseley, EA, Lopez‐Charcas, O, Wei, Y, Li, D, Muench, SP, Roger, S, Wang, L, Jiang, L

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/197729/7/Medicinal%20Research%20Reviews%20-%202023%20-%20Yin%20-%20Leveraging%20the%20ATP%E2%80%90P2X7%20receptor%20signalling%20axis%20to%20alleviate%20traumatic%20CNS.pdf; Yin, Y, Wei, L, Caseley, EA et al. (7 more authors) (2023) Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications. Medicinal Research Reviews, 43 (5). pp. 1346-1373. ISSN: 0198-6325

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/197729/

PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing

Συγγραφείς: Chuntharpursat-Bon, E, Povstyan, OV, Ludlow, MJ, Carrier, DJ, Debant, M, Shi, J, Gaunt, HJ, Bauer, CC, Curd, A, Futers, TS, Baxter, PD, Peckham, M, Muench, SP, Adamson, A, Humphreys, N, Tumova, S, Bon, RS, Cubbon, R, Lichtenstein, L, Beech, DJ

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/197085/7/PIEZO1%20and%20PECAM1%20interact%20at%20cell-cell%20junctions%20and%20partner%20in%20endothelial%20force%20sensing.pdf; Chuntharpursat-Bon, E, Povstyan, OV, Ludlow, MJ et al. (17 more authors) (2023) PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing. Communications Biology, 6. 358. ISSN: 2399-3642

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/197085/

Spherical-supported membranes as platforms for screening against membrane protein targets

Συγγραφείς: Vasilca, V, Sadeghpour, A, Rawson, S, Hawke, LE, Baldwin, SA, Wilkinson, T, Bannister, D, Postis, VLG, Rappolt, M, Muench, SP, Jeuken, LJC

Συνεισφορές: Vasilca, V, Sadeghpour, A, Rawson, S, Hawke, LE, Baldwin, SA, Wilkinson, T, Bannister, D, Postis, VLG, Muench, SP

Πηγή: Anal Biochem
Analytical biochemistry.-2018

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Escherichia coli Proteins, Cryoelectron Microscopy, Lipid Bilayers, Membrane Transport Proteins, Article, Protein Structure, Secondary, 3. Good health, Epitopes, 03 medical and health sciences, X-Ray Diffraction, Scattering, Small Angle, Escherichia coli

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/29545094
https://eprints.whiterose.ac.uk/128471/10/1-s2.0-S0003269718302628-main.pdf
https://sonar.ch/global/documents/58475
https://eprints.whiterose.ac.uk/id/eprint/128471/

SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis

Συγγραφείς: Pollock, NL, Rai, M, Simon, KS, Hesketh, SJ, Teo, ACK, Parmar, M, Sridah, P, Collins, R, Lee, SC, Stroud, ZN, Bakker, SE, Muench, SP, Barton, H, Hurlbut, G, Roper, DI, Smith, CJI, Knowles, TJ, Spickett, CM, East, JM, Postis, V, Dafforn, TR

Πηγή: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1861:1437-1445

Θεματικοί όροι: 0301 basic medicine, SMALP, 0303 health sciences, Blotting, Western, Protein complex, Membrane Proteins, QP, Lipids, Mass Spectrometry, Native Polyacrylamide Gel Electrophoresis, Microscopy, Electron, 03 medical and health sciences, Nanoparticle, Membrane protein, Native PAGE, Nanotechnology, Protein Structure, Quaternary

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/31150633
https://eprints.leedsbeckett.ac.uk/id/eprint/5962/1/SMA-PAGE_ANewMethodToExamineComplexesOfMembraneProteinsAM_POSTIS.pdf
http://wrap.warwick.ac.uk/117844/1/WRAP-SMA-PAGE-new-method-examine-complexes-membrane-proteins-SMALP-nano-encapsulation-native-gel-electrophoresis-Roper-2019.pdf
https://publications.aston.ac.uk/id/eprint/39895/1/newmethodtoexaminecomplexesofmembrane.pdf
https://eprints.whiterose.ac.uk/id/eprint/146483/

Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A.

Συγγραφείς: Liu, Y, De Castro Ribeiro, O, Haapanen, O, Craven, GB, Sharma, V, Muench, SP, Goldman, A

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/190543/12/1-s2.0-S0021925822008237-main.pdf; Liu, Y, De Castro Ribeiro, O, Haapanen, O et al. (4 more authors) (2022) Unexpected structures formed by the kinase RET C634R mutant extracellular domain suggest potential oncogenic mechanisms in MEN2A. Journal of Biological Chemistry, 298 (10). 102380. 102380-. ISSN: 0021-9258

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/190543/

It started with a Cys: Spontaneous cysteine modification during cryo-EM grid preparation

Συγγραφείς: Klebl, DP, Wang, Y, Sobott, F, Thompson, RF, Muench, SP

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/188501/3/It%20started%20with%20a%20Cys%20Spontaneous%20cysteine%20modification%20during%20cryo-EM%20grid%20preparation.pdf; Klebl, DP, Wang, Y, Sobott, F orcid.org/0000-0001-9029-1865 et al. (2 more authors) (2022) It started with a Cys: Spontaneous cysteine modification during cryo-EM grid preparation. Frontiers in Molecular Biosciences, 9. 945772. ISSN: 2296-889X

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/188501/

Maintaining the momentum in cryoEM for biological discovery

Συγγραφείς: Halfon, Y, Aspinall, L, White, J, Jackson Hirst, I, Wang, Y, Darrow, MC, Muench, SP, Thompson, RF

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/193862/1/d2fd00129b.pdf; Halfon, Y, Aspinall, L, White, J et al. (5 more authors) (2022) Maintaining the momentum in cryoEM for biological discovery. Faraday Discussions, 240. pp. 18-32. ISSN: 1359-6640

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/193862/
https://eprints.whiterose.ac.uk/id/eprint/193862/1/d2fd00129b.pdf

Detergent-Free Functionalization of Hybrid Vesicles with Membrane Proteins Using SMALPs

Συγγραφείς: Catania, R, Machin, J, Rappolt, M, Muench, SP, Beales, PA, Jeuken, LJC

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/186081/10/acs.macromol.2c00326.pdf; Catania, R, Machin, J, Rappolt, M orcid.org/0000-0001-9942-3035 et al. (3 more authors) (2022) Detergent-Free Functionalization of Hybrid Vesicles with Membrane Proteins Using SMALPs. Macromolecules, 55 (9). pp. 3415-3422. ISSN: 0024-9297

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/186081/
https://eprints.whiterose.ac.uk/id/eprint/186081/10/acs.macromol.2c00326.pdf

Recent Developments in the Structural Characterisation of the IR and IGF1R: Implications for the Design of IR-IGF1R Hybrid Receptor Modulators

Συγγραφείς: Turvey, SJ, McPhillie, MJ, Kearney, MT, Muench, SP, Simmons, KJ, Fishwick, CWG

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/182507/74/d1md00300c.pdf; Turvey, SJ orcid.org/0000-0003-4298-8339 , McPhillie, MJ orcid.org/0000-0001-8264-8211 , Kearney, MT et al. (3 more authors) (2022) Recent Developments in the Structural Characterisation of the IR and IGF1R: Implications for the Design of IR-IGF1R Hybrid Receptor Modulators. RSC Medicinal Chemistry, 2022 (4). pp. 360-374. ISSN: 2632-8682

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/182507/
https://eprints.whiterose.ac.uk/id/eprint/182507/74/d1md00300c.pdf

Moving in the mesoscale: Understanding the mechanics of cytoskeletal molecular motors by combining mesoscale simulations with imaging

Συγγραφείς: Gravett, MSC, Cocking, RC, Curd, AP, Harlen, O, Leng, J, Muench, SP, Peckham, M, Read, DJ, Rogers, JF, Welch, RC, Harris, SA

Περιγραφή αρχείου: text

Relation: https://eprints.whiterose.ac.uk/id/eprint/177851/1/WIREs%20Comput%20Mol%20Sci%20-%202021%20-%20Gravett%20-%20Moving%20in%20the%20mesoscale%20%20Understanding%20the%20mechanics%20of%20cytoskeletal%20molecular.pdf; Gravett, MSC orcid.org/0000-0001-8351-7176 , Cocking, RC, Curd, AP orcid.org/0000-0002-3949-7523 et al. (8 more authors) (Cover date: May/June 2022) Moving in the mesoscale: Understanding the mechanics of cytoskeletal molecular motors by combining mesoscale simulations with imaging. Wiley Interdisciplinary Reviews: Computational Molecular Science, 12 (3). e1570. ISSN: 1759-0884

Διαθεσιμότητα: https://eprints.whiterose.ac.uk/id/eprint/177851/

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies

Συγγραφείς: Wright, J, Muench, SP, Goldman, A, Baker, A

Πηγή: Biochemical Society Transactions. 46:1475-1484

Θεματικοί όροι: 0301 basic medicine, 03 medical and health sciences, ABC transport proteins, protein conformation, Protein Conformation, structural biology, Animals, Humans, ATP-Binding Cassette Transporters, Protein Binding, Substrate Specificity

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: http://eprints.whiterose.ac.uk/139799/1/Wright%20et%20al_2018.pdf
https://pubmed.ncbi.nlm.nih.gov/30514765
https://eprints.whiterose.ac.uk/id/eprint/139799/