Origin, pathogenicity, and transmissibility of a human isolated influenza A(H10N3) virus from China.

Authors: Zhu W; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China., Yang L; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China., Han X; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.; Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China., Tan M; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China., Zou S; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China., Li X; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China., Huang W; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China., Zeng X; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China., Wang D; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), NHC Key Laboratory of Medical Virology and Viral Diseases, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, Beijing, People's Republic of China.

Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2432364. Date of Electronic Publication: 2024 Dec 09.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH Terms: Influenza, Human*/virology , Influenza, Human*/transmission , Phylogeny* , Mice, Inbred BALB C* , Ferrets*/virology , Influenza in Birds*/virology , Influenza in Birds*/transmission , Influenza A virus*/pathogenicity , Influenza A virus*/genetics , Influenza A virus*/isolation & purification , Influenza A virus*/classification , Influenza A virus*/physiology, Animals ; Humans ; China/epidemiology ; Mice ; Mice, Inbred C57BL ; Orthomyxoviridae Infections/virology ; Orthomyxoviridae Infections/transmission ; Orthomyxoviridae Infections/veterinary ; Poultry/virology ; Female ; Virulence

Piezo1 aggravates ischemia/reperfusion-induced acute kidney injury by Ca ²⁺ -dependent calpain/HIF-1α/Notch signaling.

Authors: Chen X; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Jiang J; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., He B; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Luo S; Medical Research Center, Shandong University of Traditional Chinese Medicine, Jinan, China., Tan Q; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Yao Y; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Wan R; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Xu H; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Liu S; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Pan X; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Chen X; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China., Li J; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, China.; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.; Medical Research Center, Shandong University of Traditional Chinese Medicine, Jinan, China.; Faculty of Biological Sciences, University of Leeds, UK.

Source: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2447801. Date of Electronic Publication: 2025 Jan 08.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH Terms: Acute Kidney Injury*/metabolism , Acute Kidney Injury*/etiology , Reperfusion Injury*/metabolism , Calpain*/metabolism , Macrophages*/metabolism , Ion Channels*/metabolism , Ion Channels*/genetics , Signal Transduction* , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Mice, Knockout*, Animals ; Mice ; Male ; Calcium/metabolism ; Receptors, Notch/metabolism ; Mice, Inbred C57BL ; Kidney/pathology ; Kidney/metabolism ; Kidney/blood supply ; Disease Models, Animal

Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism.

Authors: Prince N; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Peralta Marzal LN; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Roussin L; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Monnoye M; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France., Philippe C; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France., Maximin E; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France., Ahmed S; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Salenius K; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere, Finland., Lin J; Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland., Autio R; Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland., Adolfs Y; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, Netherlands., Garssen J; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Danone Nutricia Research, Utrecht, Netherlands., Naudon L; Université Paris-Saclay, INRAE, AgroParisTech, CNRS, Micalis Institute, Jouy-en-Josas, France., Rabot S; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France., Kraneveld AD; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.; Department of Neuroscience, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Perez-Pardo P; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2447822. Date of Electronic Publication: 2025 Jan 07.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Fecal Microbiota Transplantation* , Gastrointestinal Microbiome* , Mice, Inbred C57BL* , Brain-Gut Axis*/physiology , Mice, Inbred BALB C*, Animals ; Humans ; Mice ; Male ; Child ; Autism Spectrum Disorder/microbiology ; Dysbiosis/microbiology ; Feces/microbiology ; Disease Models, Animal ; Autistic Disorder/microbiology ; Autistic Disorder/physiopathology ; Female ; Social Behavior ; Species Specificity ; Bacteria/classification ; Bacteria/isolation & purification ; Bacteria/genetics ; Bacteria/metabolism

Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation.

Authors: Wang P; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Wang R; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Zhao W; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Zhao Y; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Wang D; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Zhao S; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Ge Z; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Ma Y; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China., Zhao X; Institute of Agri-Food Processing and Nutrition, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China.; Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing, Key Laboratory of Vegetable Postharvest Processing, Ministry of Agriculture and Rural Affairs, Beijing, China.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2446391. Date of Electronic Publication: 2024 Dec 26.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Gastrointestinal Microbiome*/drug effects , Sirtuin 1*/metabolism , Obesity*/metabolism , Obesity*/prevention & control , Obesity*/microbiology , Resveratrol*/pharmacology , Resveratrol*/administration & dosage , Phenylacetates*/pharmacology , Phenylacetates*/metabolism , Signal Transduction*/drug effects , Diet, High-Fat*/adverse effects , Mice, Inbred C57BL*, Animals ; Mice ; Male ; Dysbiosis/microbiology ; Dysbiosis/prevention & control ; Adipose Tissue, White/metabolism ; Adipose Tissue, White/drug effects ; Anti-Obesity Agents/pharmacology ; Anti-Obesity Agents/administration & dosage ; Dietary Supplements ; Bacteria/classification ; Bacteria/metabolism ; Bacteria/drug effects ; Bacteria/genetics ; Fecal Microbiota Transplantation

T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota.

Authors: Marques de Souza PR; Department of Health Education, Federal University of Sergipe, Aracaju, SE, Brazil.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Keenan CM; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Wallace LE; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Habibyan YB; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Davoli-Ferreira M; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Ohland C; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Vicentini FA; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, ON, Canada., McCoy KD; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Sharkey KA; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2442528. Date of Electronic Publication: 2024 Dec 20.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Gastrointestinal Microbiome* , Enteric Nervous System*/physiology , Enteric Nervous System*/immunology , Enteric Nervous System*/microbiology , Gastrointestinal Motility*/physiology , Mice, Inbred C57BL* , Ileum*/microbiology , Ileum*/immunology, Animals ; Mice ; T-Lymphocytes/immunology ; Colon/microbiology ; Colon/immunology ; Neurogenesis ; Neurons/physiology ; Neurons/microbiology ; Specific Pathogen-Free Organisms ; Male ; Interleukin-17/metabolism ; Nestin/metabolism ; Nestin/genetics ; Germ-Free Life ; Th17 Cells/immunology ; Bacteria/classification

Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation.

Authors: Jiang L; Department of Endocrinology and Metabolism, People's Hospital of Yichun City, Yichun, Jiangxi, People's Republic of China., Yi R; Department of Endocrinology and Metabolism, People's Hospital of Yichun City, Yichun, Jiangxi, People's Republic of China., Chen H; Department of Endocrinology and Metabolism, People's Hospital of Yichun City, Yichun, Jiangxi, People's Republic of China., Wu S; Department of Endocrinology and Metabolism, People's Hospital of Yichun City, Yichun, Jiangxi, People's Republic of China.

Source: Animal biotechnology [Anim Biotechnol] 2025 Dec; Vol. 36 (1), pp. 2442351. Date of Electronic Publication: 2024 Dec 24.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9011409 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2378 (Electronic) Linking ISSN: 10495398 NLM ISO Abbreviation: Anim Biotechnol Subsets: MEDLINE

MeSH Terms: Quercetin*/pharmacology , Oxidative Stress*/drug effects , Lipid Metabolism*/drug effects , Mice, Inbred C57BL* , Liver*/drug effects , Liver*/metabolism , Diet, High-Fat*/adverse effects , Inflammation*/drug therapy , Inflammation*/metabolism, Animals ; Male ; Mice ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/metabolism ; Antioxidants/pharmacology ; Fatty Liver/drug therapy ; Fatty Liver/metabolism

Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production.

Authors: Tian Y; Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China., Zhou C; Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China., Yan Q; Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China., Li Z; Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China., Chen D; Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China., Feng B; Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China., Song J; Department of Endocrinology, East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.

Source: Renal failure [Ren Fail] 2025 Dec; Vol. 47 (1), pp. 2438857. Date of Electronic Publication: 2025 Jan 02.

Publication Type: Journal Article

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

MeSH Terms: Ferroptosis*/drug effects , Glucosides*/pharmacology , Glucosides*/therapeutic use , Diabetic Nephropathies*/drug therapy , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology , Benzhydryl Compounds*/pharmacology , Benzhydryl Compounds*/therapeutic use , Mice, Inbred C57BL* , Sodium-Glucose Transporter 2 Inhibitors*/pharmacology , Sodium-Glucose Transporter 2 Inhibitors*/therapeutic use , Lipid Peroxidation*/drug effects , 3-Hydroxybutyric Acid*/pharmacology, Animals ; Mice ; Humans ; Male ; Cell Line ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/drug effects ; Kidney Tubules, Proximal/pathology ; Blood Glucose/metabolism ; Blood Glucose/drug effects ; Amino Acid Transport System y+

Replication kinetics, pathogenicity and virus-induced cellular responses of cattle-origin influenza A(H5N1) isolates from Texas, United States.

Authors: Mostafa A; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA.; Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza, Egypt.; International Center for the Advancement of Research and Education (I•CARE), Texas Biomedical Research Institute, San Antonio, TX, USA., Barre RS; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Allué-Guardia A; Population Health Program, Tuberculosis Group, Texas Biomedical Research Institute, San Antonio, TX, USA., Escobedo RA; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Shivanna V; Southwest National Primate Research Center at the Texas Biomedical Research Institute, San Antonio, TX, USA., Rothan H; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Castro EM; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Ma Y; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Cupic A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jackson N; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA., Bayoumi M; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA.; Virology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Torrelles JB; International Center for the Advancement of Research and Education (I•CARE), Texas Biomedical Research Institute, San Antonio, TX, USA.; Population Health Program, Tuberculosis Group, Texas Biomedical Research Institute, San Antonio, TX, USA., Ye C; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Icahn Genomics Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Martinez-Sobrido L; Host-pathogen interactions (HPI) and Disease Intervention and Prevention (DIP) programs, Texas Biomedical Research Institute, San Antonio, TX, USA.

Source: Emerging microbes & infections [Emerg Microbes Infect] 2025 Dec; Vol. 14 (1), pp. 2447614. Date of Electronic Publication: 2025 Jan 08.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE

MeSH Terms: Virus Replication* , Influenza A Virus, H5N1 Subtype*/genetics , Influenza A Virus, H5N1 Subtype*/pathogenicity , Influenza A Virus, H5N1 Subtype*/isolation & purification , Influenza A Virus, H5N1 Subtype*/physiology , Influenza A Virus, H5N1 Subtype*/drug effects , Orthomyxoviridae Infections*/virology , Orthomyxoviridae Infections*/veterinary , Mice, Inbred C57BL*, Animals ; Cattle ; Texas ; Mice ; Humans ; Influenza, Human/virology ; Dogs ; Virulence ; Cattle Diseases/virology ; Cytokines/metabolism ; Female ; Madin Darby Canine Kidney Cells ; Kinetics ; Lung/virology ; Host Specificity

Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation.

Authors: Petersen C; Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA., Satheesh Babu AK; Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA., Della Lucia CM; Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA., Paz HA; Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Iglesias-Carres L; Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, USA., Zhong Y; Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Jalili T; Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA., Symons JD; Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA., Shankar K; Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Neilson AP; Plants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, USA., Wankhade UD; Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Anandh Babu PV; Department of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.

Source: Gut microbes [Gut Microbes] 2025 Dec; Vol. 17 (1), pp. 2446375. Date of Electronic Publication: 2025 Jan 06.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101495343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1949-0984 (Electronic) Linking ISSN: 19490976 NLM ISO Abbreviation: Gut Microbes Subsets: MEDLINE

MeSH Terms: Fragaria*/microbiology , Gastrointestinal Microbiome*/drug effects , Mice, Inbred C57BL* , Dysbiosis*/microbiology , Phytochemicals*/pharmacology , Phytochemicals*/metabolism , Diet, High-Fat*/adverse effects, Animals ; Mice ; Male ; Bacteria/classification ; Bacteria/metabolism ; Bacteria/drug effects ; Inflammation/metabolism ; Inflammation/drug therapy ; Propionates/metabolism ; Coumaric Acids/metabolism ; Coumaric Acids/pharmacology ; Anti-Bacterial Agents/pharmacology ; Humans

Mapping the sialic acid-binding sites of LuIII and H-1 parvovirus.

Authors: Busuttil K; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Pittman N; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Zachary J; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Halder S; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Geilen L; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Singh A; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Misseldine A; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Kaplonek P; Department of Biomolecular Systems, Max-Planck Institute of Colloids and Interfaces, Potsdam, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany., Chipman P; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Heimburg-Molinaro J; Department of Surgery, Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, Harvard Medical School, Center for Life Sciences, Boston, Massachusetts, USA., Seeberger PH; Department of Biomolecular Systems, Max-Planck Institute of Colloids and Interfaces, Potsdam, Germany.; Institute of Chemistry and Biochemistry, Free University of Berlin, Berlin, Germany., Mietzsch M; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., Bennett AD; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA., McKenna R; Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, USA.

Source: Journal of virology [J Virol] 2025 Aug 19; Vol. 99 (8), pp. e0029725. Date of Electronic Publication: 2025 Jul 24.

Publication Type: Journal Article

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

MeSH Terms: N-Acetylneuraminic Acid*/metabolism , N-Acetylneuraminic Acid*/chemistry , H-1 parvovirus*/metabolism , H-1 parvovirus*/chemistry , Receptors, Virus*/metabolism , Receptors, Virus*/chemistry , Minute Virus of Mice*/metabolism , Minute Virus of Mice*/chemistry, Binding Sites ; Humans ; Animals ; Polysaccharides/metabolism ; Mice ; Capsid Proteins/metabolism ; Capsid Proteins/chemistry ; Virus Attachment

The Collaborative Cross as a Model for Studying Viral Infections.

Authors: Sylvester PA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Heise MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; email: heisem@med.unc.edu.

Source: Annual review of virology [Annu Rev Virol] 2025 Sep; Vol. 12 (1), pp. 401-419. Date of Electronic Publication: 2025 May 06.

Publication Type: Journal Article; Review

Journal Info: Publisher: Annual Reviews Country of Publication: United States NLM ID: 101625721 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2327-0578 (Electronic) Linking ISSN: 2327056X NLM ISO Abbreviation: Annu Rev Virol Subsets: MEDLINE

MeSH Terms: Virus Diseases*/virology , Virus Diseases*/genetics , Disease Models, Animal* , Collaborative Cross Mice* , Host-Pathogen Interactions*/genetics , Viruses*/pathogenicity , Viruses*/genetics, Animals ; Mice ; Humans ; Genetic Variation ; Genetic Predisposition to Disease

Developing a Model for Virus Contamination in Perfusion Bioreactors to Establish Rational Control Strategies for Integrated Continuous Bioprocessing.

Authors: Ito T; Merck Ltd. (An Affiliate of Merck KGaA, Darmstadt, Germany), Koto-ku, Tokyo, Japan., Nihei T; Takeda Pharmaceutical Co. Ltd., Fujisawa, Kanagawa, Japan., Yamamoto K; Kyowa Kirin Co. Ltd., Takasaki, Gunma, Japan., Watanabe N; Toyo Kensa Center Co. Ltd., Nobeoka, Miyazaki, Japan., Tokieda Y; KM Biologics Co. Ltd., Kikuchi, Kumamoto, Japan., Masuda Y; Daiichi Sankyo Co. Ltd., Oura-gun, Gunma, Japan., Okada M; Life Scientia Ltd., Yokohama, Kanagawa, Japan.

Source: Biotechnology and bioengineering [Biotechnol Bioeng] 2025 Aug; Vol. 122 (8), pp. 2072-2081. Date of Electronic Publication: 2025 May 13.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7502021 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0290 (Electronic) Linking ISSN: 00063592 NLM ISO Abbreviation: Biotechnol Bioeng Subsets: MEDLINE

MeSH Terms: Bioreactors*/virology , Models, Biological* , Minute Virus of Mice*/isolation & purification , Virus Cultivation*/methods , Viruses*/isolation & purification, Animals ; Cell Culture Techniques/methods ; Mice

The mouse resource at National Resource Center for Mutant Mice of China.

Authors: Han B; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China., Chen D; National Resource Center for Mutant Mice, Model Animal Research Center of Nanjing University, Nanjing, China., Chen Z; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China., Wang T; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China., Zi K; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China., Feng R; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China., Yang X; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China., Li L; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China., Liang J; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China. liangjuan@gempharmatech.com., Gao X; National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China. gaoxiang@nju.edu.cn.; National Resource Center for Mutant Mice, Model Animal Research Center of Nanjing University, Nanjing, China. gaoxiang@nju.edu.cn.; GemPharmatech Co., Ltd., Guangdong, China. gaoxiang@nju.edu.cn.

Source: Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2025 Jun; Vol. 36 (2), pp. 512-522. Date of Electronic Publication: 2025 Mar 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer-Verlag Country of Publication: United States NLM ID: 9100916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1777 (Electronic) Linking ISSN: 09388990 NLM ISO Abbreviation: Mamm Genome Subsets: MEDLINE

MeSH Terms: Disease Models, Animal* , Mice, Mutant Strains*/genetics, Animals ; Mice ; China ; Gene Editing ; Mice, Knockout ; Mutation

Anti-HBV activity of (R)-gentiandiol, a metabolite of Swertiamarin, in transgenic mice: Insights from non-targeted serum metabolomics.

Authors: Sun Y; Department of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin 150040, China., Tang S; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan; Heilongjiang Hospital, Beijing Children's Hospital (Jiangnan Area, the Sixth Affiliated Hospital of Harbin Medical University), Youyi road 57, Harbin, China., Xu Y; Department of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin 150040, China., Li H; Department of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin 150040, China., Li P; Department of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin 150040, China., Hattori M; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan., Zhang H; School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Shaanxi 710061, China., Li X; Department of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin 150040, China., Wang Z; Department of Pharmaceutical Analysis, College of Pharmacy, Heilongjiang University of Chinese Medicine, Heping road 24, Harbin 150040, China; Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: wangzhigang0513@vip.163.com.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Apr 15; Vol. 121, pp. 118128. Date of Electronic Publication: 2025 Feb 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH Terms: Mice, Transgenic* , Mice, Inbred C57BL* , Hepatitis B virus*/drug effects , Metabolomics* , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry , Pyrones*/pharmacology , Pyrones*/chemistry , Iridoid Glucosides*/pharmacology , Iridoid Glucosides*/chemistry, Animals ; Mice ; Dose-Response Relationship, Drug ; Humans ; Hepatitis B Surface Antigens/metabolism ; DNA, Viral/drug effects ; DNA, Viral/blood ; Structure-Activity Relationship ; Molecular Structure ; Hepatitis B/drug therapy ; Male

Design, synthesis, biological evaluation, and mechanism of action of new pyrazines as anticancer agents in vitro and in vivo.

Authors: Lan JX; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China; School of Public Health and Health Management, Gannan Medical University, Ganzhou 341000 PR China., Huang LJ; School of Rehabilitation, Gannan Medical University, Ganzhou 341000 PR China., Kang SS; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China., Hao-Huang; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China., Liu SL; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China., Dai W; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China., Xu XL; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China., Wang JY; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China., Shu GZ; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China., Hou W; Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou 341000 PR China. Electronic address: twenhou@gmu.edu.cn.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2025 Apr 15; Vol. 121, pp. 118108. Date of Electronic Publication: 2025 Feb 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

MeSH Terms: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Drug Design* , Pyrazines*/chemistry , Pyrazines*/pharmacology , Pyrazines*/chemical synthesis , Apoptosis*/drug effects , Cell Proliferation*/drug effects , Mice, Nude* , Drug Screening Assays, Antitumor*, Humans ; Animals ; Mice ; Structure-Activity Relationship ; STAT3 Transcription Factor/metabolism ; STAT3 Transcription Factor/antagonists & inhibitors ; Cell Line, Tumor ; Molecular Structure ; Mice, Inbred BALB C ; Female ; Dose-Response Relationship, Drug

Vitexin alleviates lipid metabolism disorders and hepatic injury in obese mice through the PI3K/AKT/mTOR/SREBP-1c pathway.

Authors: Liu B; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Yao Z; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Song L; Department of Pharmacy, Children' S Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, 400014, China., Sun C; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Shen C; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Cheng F; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Cheng Z; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China., Zhang R; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address: zhangruoqi@cdutcm.edu.cn., Liu R; State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address: liurong1116@126.com.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Apr 05; Vol. 287, pp. 117379. Date of Electronic Publication: 2025 Feb 07.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Apigenin*/pharmacology , Apigenin*/chemistry , Mice, Inbred C57BL* , Proto-Oncogene Proteins c-akt*/metabolism , TOR Serine-Threonine Kinases*/metabolism , Phosphatidylinositol 3-Kinases*/metabolism , Obesity*/drug therapy , Sterol Regulatory Element Binding Protein 1*/metabolism, Animals ; Mice ; Male ; Signal Transduction/drug effects ; Mice, Obese ; Diet, High-Fat/adverse effects ; Lipid Metabolism Disorders/drug therapy ; Lipid Metabolism Disorders/metabolism ; Lipid Metabolism/drug effects ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Dose-Response Relationship, Drug ; Molecular Structure ; Structure-Activity Relationship

Design, synthesis and evaluation of diarylidenyl piperidone-ligated platinum (IV) complexes as chemoimmunotherapeutic agents.

Authors: Mao ZC; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China., Chen L; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China., Chen XM; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China., Lu XY; College of Pharmacy, Jinan University, 511436, Guangzhou, China., Mo ZY; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China., Gou Y; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China., Wei JH; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China. Electronic address: weijh1124@glmc.edu.cn., Huang RZ; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China. Electronic address: rzhuang1783@163.com., Zhang Y; Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China; Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, School of Pharmacy, Guilin Medical University, 541199, Guilin, Guangxi, China. Electronic address: zhangye81@126.com.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Apr 05; Vol. 287, pp. 117338. Date of Electronic Publication: 2025 Jan 30.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemical synthesis , Antineoplastic Agents*/chemistry , Piperidones*/pharmacology , Piperidones*/chemistry , Piperidones*/chemical synthesis , Mice, Nude* , Drug Design* , Cell Proliferation*/drug effects , Mice, Inbred BALB C*, Humans ; Animals ; Mice ; Molecular Structure ; Structure-Activity Relationship ; Drug Screening Assays, Antitumor ; Dose-Response Relationship, Drug ; Organoplatinum Compounds/pharmacology ; Organoplatinum Compounds/chemistry ; Organoplatinum Compounds/chemical synthesis ; Cell Line, Tumor ; Immunotherapy ; Apoptosis/drug effects ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Coordination Complexes/chemical synthesis ; STAT3 Transcription Factor/antagonists & inhibitors ; STAT3 Transcription Factor/metabolism ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology

A size-switchable nanocluster remodels the immunosuppressive microenvironment of tumor and tumor-draining lymph nodes for improved cancer immunotherapy.

Authors: Tong QS; Department of Pharmacy, the First Affiliated Hospital of Anhui Medical University, Hefei, 230031, China; School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, China., Huang H; School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, China., Yu HH; School of Medicine, South China University of Technology, Guangzhou, 510006, China., Liu R; School of Medicine, South China University of Technology, Guangzhou, 510006, China., Shen S; School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, 511442, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China. Electronic address: shensong@scut.edu.cn., Du JZ; School of Medicine, South China University of Technology, Guangzhou, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, China; Guangdong Provincial Key Laboratory of Biomedical Engineering, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510006, China. Electronic address: djzhi@scut.edu.cn.

Source: Biomaterials [Biomaterials] 2025 Apr; Vol. 315, pp. 122910. Date of Electronic Publication: 2024 Oct 22.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

MeSH Terms: Tumor Microenvironment*/drug effects , Tumor Microenvironment*/immunology , Lymph Nodes*/drug effects , Lymph Nodes*/immunology , Lymph Nodes*/pathology , Immunotherapy*/methods , Imidazoles*/chemistry , Imidazoles*/pharmacology , Mice, Inbred C57BL*, Animals ; Female ; Mice ; Cell Line, Tumor ; Nanoparticles/chemistry ; Dendritic Cells/immunology ; Dendritic Cells/drug effects ; Mice, Inbred BALB C ; Humans ; Macrophages/drug effects ; Macrophages/immunology ; Dendrimers/chemistry ; Particle Size

Discovery of novel oleanolic acid glycoside derivatives targeting PTP1B/PI3K/AKT signaling pathway for the treatment of breast cancer.

Authors: Song X; Department of Pharmaceutical Engineering, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, PR China., Wang L; Department of Pharmaceutical Engineering, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, PR China., Liu Y; Technological Institute of Materials & Energy Science (TIMES), Key Laboratory of Liquid Crystal Polymers based Flexible Display Technology in National Petroleum and Chemical Industry, Xi'an Key Laboratory of Advanced Photo-electronics Materials and Energy Conversion Device, School of Electronic Information, Xijing University, Xi'an 710123, PR China., Xu K; Department of Pharmaceutical Engineering, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, PR China., Cai P; Department of Pharmaceutical Engineering, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, PR China., Liu J; Department of Pharmaceutical Engineering, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, PR China., Liu Q; Department of Pharmaceutical Engineering, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, PR China; Biotech. & Biomed. Research Institute, Northwest University, 229 Taibai North Road, Xi'an, 710069, PR China. Electronic address: liuqc21@nwu.edu.cn., Fan D; Department of Pharmaceutical Engineering, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, PR China; Biotech. & Biomed. Research Institute, Northwest University, 229 Taibai North Road, Xi'an, 710069, PR China. Electronic address: fandaidi@nwu.edu.cn.

Source: Bioorganic chemistry [Bioorg Chem] 2025 Apr; Vol. 157, pp. 108296. Date of Electronic Publication: 2025 Feb 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Protein Tyrosine Phosphatase, Non-Receptor Type 1*/antagonists & inhibitors , Protein Tyrosine Phosphatase, Non-Receptor Type 1*/metabolism , Oleanolic Acid*/pharmacology , Oleanolic Acid*/chemistry , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/antagonists & inhibitors , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Phosphatidylinositol 3-Kinases*/metabolism , Signal Transduction*/drug effects , Cell Proliferation*/drug effects , Mice, Nude*, Humans ; Female ; Animals ; Mice ; Structure-Activity Relationship ; Molecular Structure ; Drug Screening Assays, Antitumor ; Glycosides/chemistry ; Glycosides/pharmacology ; Glycosides/chemical synthesis ; Dose-Response Relationship, Drug ; Drug Discovery ; Apoptosis/drug effects ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/chemical synthesis ; Mice, Inbred BALB C

SNX3 mediates heart failure by interacting with HMGB1 and subsequently facilitating its nuclear-cytoplasmic translocation.

Authors: Li H; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.; The Research Center of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China., Peng MX; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Yang RX; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.; The Research Center of Basic Integrative Medicine, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China., Chen JX; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Wang YM; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Wang PX; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Hu YH; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China., Pan DY; Department of Pharmacy, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510378, China., Liu PQ; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. liupq@mail.sysu.edu.cn., Lu J; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Guangdong Province Engineering Laboratory for Druggability and New Drug Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. lujing28@mail.sysu.edu.cn.

Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Apr; Vol. 46 (4), pp. 964-975. Date of Electronic Publication: 2025 Jan 03.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE

MeSH Terms: Heart Failure*/metabolism , HMGB1 Protein*/metabolism , Mice, Inbred C57BL* , Myocytes, Cardiac*/metabolism , Rats, Sprague-Dawley* , Sorting Nexins*/metabolism, Animals ; Male ; Mice ; Rats ; Cell Nucleus/metabolism ; Cells, Cultured ; Cytoplasm/metabolism ; Mice, Knockout ; Protein Transport