Lysosomal Lipid Dysregulation in Parkinson's Disease: Genetic and Medication Effects in CSF Metabolomics

Συγγραφείς: Suh, Jung H., Maciuca, Romeo, Davis, Sonnet, Kluss, Jillian H., Yazd, Hoda Safari, Alkabsh, Jamal, Schwarzchild, Michael, Huntwork-Rodriguez, Sarah

Θεματικοί όροι: Metabolic Networks and Pathways/genetics, Lipidomics, Metabolomics, Parkinson Disease, Supervised Machine Learning, Parkinson Disease/genetics

MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality

Συγγραφείς: Adriaan van der Graaf, Robert Warmerdam, Chiara Auwerx, Toni Boltz, Dorret I. Boomsma, Andrew Brown, Evans Cheruiyot, Emma E. Davenport, Théo Dupuis, Tõnu Esko, Aiman Farzeen, Luigi Ferrucci, Timothy M. Frayling, Greg Gibson, Christian Gieger, Marleen van Greevenbroek, Binisha Hamal Mishra, M. Arfan Ikram, Michael Inouye, Rick Jansen, Mika Kähönen, Viktorija Kukushkina, Sandra Lapinska, Terho Lehtimäki, Reedik Mägi, Angel Martinez-Perez, Allan F. McRae, Joyce van Meurs, Lili Milani, Grant W. Montgomery, Sini Nagpal, Matthias Nauck, Roel Ophoff, Bogdan Pasaniuc, Dirk S. Paul, Elodie Persyn, Annette Peters, Holger Prokisch, Olli T. Raitakari, Emma Raitoharju, Andrew Singleton, Eline Slagboom, José Manuel Soria, Juan Carlos Souto, Alexander Teumer, Alex Tokolyi, Jan Veldink, Joost Verlouw, Ana Viñuela, Peter M. Visscher, Uwe Völker, Stefan Weiss, Harm-Jan Westra, Andrew R. Wood, Manke Xie, Urmo Võsa, Maria Carolina Borges, Lude Franke, Zoltán Kutalik

Συνεισφορές: eQTLGen Consortium, Boltz, T., Boomsma, D.I., Brown, A., Cheruiyot, E., Davenport, E.E., Dupuis, T., Esko, T., Farzeen, A., Ferrucci, L., Frayling, T.M., Gibson, G., Gieger, C., van Greevenbroek, M., Mishra, B.H., Ikram, M.A., Inouye, M., Jansen, R., Kähönen, M., Kukushkina, V., Lapinska, S., Lehtimäki, T., Mägi, R., Martinez-Perez, A., McRae, A.F., van Meurs, J., Milani, L., Montgomery, G.W., Nagpal, S., Nauck, M., Ophoff, R., Pasaniuc, B., Paul, D.S., Persyn, E., Peters, A., Prokisch, H., Raitakari, O.T., Raitoharju, E., Singleton, A., Slagboom, E., Soria, J.M., Souto, J.C., Teumer, A., Tokolyi, A., Veldink, J., Verlouw, J., Viñuela, A., Visscher, P.M., Völker, U., Weiss, S., Westra, H.J., Wood, A.R., Xie, M.

Πηγή: Nat Commun
Nature communications, vol. 16, no. 1, pp. 6112

Θεματικοί όροι: Mendelian Randomization Analysis/methods, Genetic Pleiotropy, Humans, Quantitative Trait Loci, Linkage Disequilibrium, Causality, Computer Simulation, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Metabolic Networks and Pathways/genetics, Article, ddc

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pure.eur.nl/en/publications/a64df5d4-8d0d-4245-bd8e-273e9b05f2c2
https://doi.org/10.1038/s41467-025-60868-1
https://serval.unil.ch/notice/serval:BIB_B36431D3CE3B
https://serval.unil.ch/resource/serval:BIB_B36431D3CE3B.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_B36431D3CE3B0
https://mediatum.ub.tum.de/1791958

Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle

Συγγραφείς: Chen, Min, Koszti, Szilamer, Bonavoglia, Alessandro, Maco, Bohumil, Von Rohr, Olivier, Peng, Hong-Juan, Soldati-Favre, Dominique, Kloehn, Joachim

Πηγή: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-21 (2025)

Θεματικοί όροι: Proteomics, Toxoplasma / metabolism, Science, Protozoan Proteins, Apicoplasts / metabolism, Apicoplasts, Toxoplasma / genetics, Article, Apicoplasts / genetics, Protozoan Proteins / metabolism, Metabolic Networks and Pathways / genetics, Toxoplasma / growth & development, Animals, Toxoplasma, Protozoan Proteins / genetics, Metabolic Networks and Pathways

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40025025
https://doaj.org/article/32c9c46383ef4f9b8d4ca010a0c0af5c

Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway

Συγγραφείς: Choe, Kyonghwan, Ali, Muhammad, Lardenoije, Roy, Riemens, Renzo J.M., Pishva, Ehsan, Bickel, Horst, Weyerer, Siegfried, Hoffmann, Per, Pentzek, Michael, Riedel-Heller, Steffi, Wiese, Birgitt, Scherer, Martin, Wagner, Michael, Mastroeni, Diego, Coleman, Paul D., Ramirez, Alfredo, Ramakers, Inez H.G.B., Verhey, Frans R.J., Rutten, Bart P.F., Kenis, Gunter, van den Hove, Daniel L.A.

Πηγή: Alzheimers Res Ther
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-16 (2024)
Alzheimer's research & therapy 16(1), 259 (2024). doi:10.1186/s13195-024-01623-4

Θεματικοί όροι: Male, Epigenomics, 0301 basic medicine, 3-dioxygenase (IDO), metabolism [Tryptophan], Alzheimer's disease (AD), genetics [Alzheimer Disease], Epigenesis, Genetic, Cohort Studies, Blood, DNA Methylation/genetics [MeSH], Indoleamine 2,3-dioxygenase (IDO), Female [MeSH], Tryptophan/metabolism [MeSH], Aged, 80 and over [MeSH], Brain, Aged [MeSH], Humans [MeSH], Tryptophan (TRP), NAD/metabolism [MeSH], Epigenomics/methods [MeSH], Cohort Studies [MeSH], Temporal Lobe/metabolism [MeSH], Male [MeSH], Epigenetics, Research, Alzheimer Disease/genetics [MeSH], Transcriptome [MeSH], Alzheimer Disease/metabolism [MeSH], Epigenesis, Genetic/genetics [MeSH], Metabolic Networks and Pathways/genetics [MeSH], methods [Epigenomics], BRAIN, MACROPHAGES, DNA METHYLATION, Aged, 80 and over, genetics [Epigenesis, Genetic], 0303 health sciences, DEMENTIA, Tryptophan, Temporal Lobe, ddc, PREVALENCE, genetics [Metabolic Networks and Pathways], QUINOLINIC ACID, metabolism [NAD], Female, HEALTH, metabolism [Alzheimer Disease], Metabolic Networks and Pathways, RC321-571, Neurosciences. Biological psychiatry. Neuropsychiatry, genetics [DNA Methylation], metabolism [Temporal Lobe], MECHANISMS, KYNURENINE PATHWAY, 03 medical and health sciences, Alzheimer Disease, Humans, ddc:610, NAD(+), RC346-429, Aged, DNA Methylation, NAD, Neurology. Diseases of the nervous system, Transcriptome, Indoleamine 2

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39616392
https://doaj.org/article/d7f42511bb034992821e597dec5d1cd1
https://cris.maastrichtuniversity.nl/en/publications/ef05c789-1237-495b-8b80-932fed1a4ec9
https://doi.org/10.1186/s13195-024-01623-4
https://pub.dzne.de/record/273910
https://repository.publisso.de/resource/frl:6524444
https://mediatum.ub.tum.de/doc/1770342/document.pdf

Minimisation of metabolic networks defines a new functional class of genes

Συγγραφείς: Jansen, Giorgio, Qi, Tanda, Latora, Vito, Amoutzias, Grigoris D, Delneri, Daniela, Oliver, Stephen G, Nicosia, Giuseppe

Συνεισφορές: DSpace at Cambridge pro (8.1)

Πηγή: Nat Commun
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Jansen, G, Qi, T, Latora, V, Amoutzias, G D, Delneri, D & Nicosia, G 2024, 'Minimisation of metabolic networks defines a new functional class of genes', Nature Communications, vol. 15, no. 1, pp. 9076. https://doi.org/10.1038/s41467-024-52816-2

Θεματικοί όροι: Synthetic Biology/methods, Metabolic Networks and Pathways/genetics, Science, Computational Biology, Synthetic Biology, Computer Simulation, Saccharomyces cerevisiae, Computational Biology/methods, Article, Metabolic Networks and Pathways, Saccharomyces cerevisiae/genetics

Περιγραφή αρχείου: application/pdf; application/zip; text/xml; application/vnd.ms-excel

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39482321
https://doaj.org/article/8ab333ea3ee945a3b246aaf74a5e8aa1
https://hdl.handle.net/20.500.11769/652369
https://doi.org/10.1038/s41467-024-52816-2
https://www.nature.com/articles/s41467-024-52816-2
https://www.repository.cam.ac.uk/handle/1810/375664
https://doi.org/10.1038/s41467-024-52816-2
https://www.repository.cam.ac.uk/handle/1810/373980
https://doi.org/10.1038/s41467-024-52816-2
https://doi.org/10.17863/cam.112201

The amino acid metabolism is essential for evading physical plasma-induced tumour cell death

Συγγραφείς: Klaus-Dieter Weltmann, Rajesh Kumar Gandhirajan, Thomas von Woedtke, Dorothee Meyer, Sanjeev Kumar Sagwal, Sander Bekeschus

Πηγή: Br J Cancer

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Cell Death, Plasma Gases, Article, 3. Good health, Gene Expression Regulation, Neoplastic, 03 medical and health sciences, Drug Resistance, Neoplasm, Neoplasms, Metabolome, Humans, Metabolome/drug effects [MeSH], Energy Metabolism/physiology [MeSH], Humans [MeSH], Reactive Oxygen Species/metabolism [MeSH], Neoplasms/genetics [MeSH], Metabolic Networks and Pathways/drug effects [MeSH], Neoplasms/metabolism [MeSH], Gene Expression Regulation, Neoplastic/drug effects [MeSH], Plasma Gases/pharmacology [MeSH], Cell Death/drug effects [MeSH], Drug Resistance, Neoplasm/physiology [MeSH], Neoplasms/pathology [MeSH], Neoplasms/therapy [MeSH], Cells, Cultured [MeSH], Physics, Plasma Gases/therapeutic use [MeSH], Argon/pharmacology [MeSH], HeLa Cells [MeSH], Cancer metabolism, Amino Acids/metabolism [MeSH], Argon/therapeutic use [MeSH], Metabolic Networks and Pathways/genetics [MeSH], Amino Acids, Argon, Energy Metabolism, Reactive Oxygen Species, Cells, Cultured, Metabolic Networks and Pathways, HeLa Cells

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41416-021-01335-8.pdf
https://pubmed.ncbi.nlm.nih.gov/33767419
https://www.ncbi.nlm.nih.gov/pubmed/33767419
https://www.nature.com/articles/s41416-021-01335-8.pdf
https://pubmed.ncbi.nlm.nih.gov/33767419/
https://europepmc.org/article/MED/33767419
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144554
https://www.nature.com/articles/s41416-021-01335-8
https://repository.publisso.de/resource/frl:6442874

Role of the Endocytosis of Caveolae in Intracellular Signaling and Metabolism.

Συγγραφείς: Muriel, O., Sánchez-Álvarez, M., Strippoli, R., Del Pozo, M.A.

Θεματικοί όροι: Animals, Caveolae/metabolism, Cell Membrane/genetics, Cell Membrane/metabolism, Endocytosis/genetics, Humans, Metabolic Networks and Pathways/genetics, Protein Transport/genetics, Signal Transduction/genetics

Relation: Progress in molecular and subcellular biology; https://iris.unil.ch/handle/iris/64513; serval:BIB_2226864B6107; 000454763400009

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/64513
https://doi.org/10.1007/978-3-319-96704-2_8

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms.

Συγγραφείς: Weger, B.D., Gobet, C., David, FPA, Atger, F., Martin, E., Phillips, N.E., Charpagne, A., Weger, M., Naef, F., Gachon, F.

Θεματικοί όροι: ARNTL Transcription Factors/deficiency, ARNTL Transcription Factors/genetics, Animals, Basic-Leucine Zipper Transcription Factors/genetics, Basic-Leucine Zipper Transcription Factors/metabolism, Circadian Clocks/genetics, Circadian Rhythm/genetics, Cryptochromes/deficiency, Cryptochromes/genetics, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Feeding Behavior/physiology, Gene Expression Regulation, Liver/metabolism, Male, Metabolic Networks and Pathways/genetics, Mice, Knockout, RNA, Messenger/genetics, Messenger/metabolism, Transcription Factors/genetics, Transcription Factors/metabolism, Transcriptome, circadian clock, differential rhythmicity analysis, feeding–fasting cycle, liver metabolism, transcriptomics

Περιγραφή αρχείου: application/pdf

Relation: Proceedings of the National Academy of Sciences; https://iris.unil.ch/handle/iris/241120; serval:BIB_E4689F566897; 000609633900036

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/241120
https://doi.org/10.1073/pnas.2015803118

THAP11F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation.

Συγγραφείς: Dehaene, H., Praz, V., Lhôte, P., Lopes, M., Herr, W.

Θεματικοί όροι: Cell Line, Cell Proliferation/genetics, Chromosomal Proteins, Non-Histone/genetics, DNA-Binding Proteins/genetics, Gene Expression Regulation/genetics, HEK293 Cells, Host Cell Factor C1/genetics, Humans, Metabolic Networks and Pathways/genetics, Mutation/genetics, Oxidoreductases/genetics, Promoter Regions, Genetic, Protein Binding/genetics, Repressor Proteins/genetics, Vitamin B 12/genetics, Vitamin B 12/metabolism, Vitamin B 12 Deficiency/genetics, Vitamin B 12 Deficiency/metabolism, Vitamin B 12 Deficiency/pathology

Περιγραφή αρχείου: application/pdf

Relation: PLoS ONE; https://iris.unil.ch/handle/iris/217582; serval:BIB_C37EB953998B

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/217582
https://doi.org/10.1371/journal.pone.0224646

Phenotypic switching in Pseudomonas brassicacearum involves GacS- and GacA-dependent Rsm small RNAs.

Συγγραφείς: Lalaouna, D., Fochesato, S., Sanchez, L., Schmitt-Kopplin, P., Haas, D., Heulin, T., Achouak, W.

Θεματικοί όροι: Antifungal Agents/metabolism, Bacterial Proteins/metabolism, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Metabolic Networks and Pathways/genetics, Microarray Analysis, Phenotype, Pseudomonas/genetics, Pseudomonas/physiology, RNA, Bacterial/metabolism, Small Interfering/metabolism, Transcription Factors/metabolism

Relation: Applied and Environmental Microbiology; https://iris.unil.ch/handle/iris/199865; serval:BIB_8429312A4244; 000300629800004

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/199865
https://doi.org/10.1128/AEM.06769-11

A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network.

Συγγραφείς: Amoutzias, G.D., Pichler, E.E., Mian, N., De Graaf, D., Imsiridou, A., Robinson-Rechavi, M., Bornberg-Bauer, E., Robertson, D.L., Oliver, S.G.

Θεματικοί όροι: Animals, DNA/metabolism, Databases, Protein, Evolution, Molecular, Gene Expression Regulation, Humans, Metabolic Networks and Pathways/genetics, Mice, Phylogeny, Protein Binding, Protein Interaction Mapping, Receptors, Cytoplasmic and Nuclear/classification, Cytoplasmic and Nuclear/genetics, Transcription Factors/classification, Transcription Factors/genetics

Περιγραφή αρχείου: application/pdf

Relation: BMC Systems Biology; https://iris.unil.ch/handle/iris/188829; serval:BIB_8C6B61D79078; 000250004000001

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/188829
https://doi.org/10.1186/1752-0509-1-34

In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function.

Συγγραφείς: di Iulio, J., Fayet, A., Arab-Alameddine, M., Rotger, M., Lubomirov, R., Cavassini, M., Furrer, H., Günthard, H.F., Colombo, S., Csajka, C., Eap, C.B., Decosterd, L.A., Telenti, A.

Συνεισφορές: Swiss HIV Cohort Study, Battegay, M., Bernasconi, E., Böni, J., Bucher, HC., Bürgisser, P., Calmy, A., Cattacin, S., Cavassini, M., Dubs, R., Egger, M., Elzi, L., Fischer, M., Flepp, M., Fontana, A., Francioli, P., Furrer, H., Fux, C., Gorgievski, M., Günthard, H., Hirsch, H., Hirschel, B., Hösli, I., Kahlert, Ch., Kaiser, L., Karrer, U., Kind, C., Klimkait, T., Ledergerber, B., Martinetti, G., Martinez, B., Müller, N., Nadal, D., Opravil, M., Paccaud, F., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schmid, P., Schultze, D., Schüpbach, J., Speck, R., Taffé, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S.

Θεματικοί όροι: African Continental Ancestry Group/genetics, Alleles, Anti-HIV Agents/blood, Anti-HIV Agents/chemistry, Aryl Hydrocarbon Hydroxylases/metabolism, Asian Continental Ancestry Group/genetics, Benzoxazines/blood, Benzoxazines/chemistry, European Continental Ancestry Group/genetics, Gene Frequency, Genetic Variation, Hispanic Americans/genetics, Humans, Metabolic Networks and Pathways/genetics, Molecular Structure, Pharmacogenetics, Polymorphism, Single Nucleotide

Relation: Pharmacogenetics and Genomics; https://iris.unil.ch/handle/iris/137607; serval:BIB_69748BF486BC; 000264943900006

Διαθεσιμότητα: https://iris.unil.ch/handle/iris/137607
https://doi.org/10.1097/FPC.0b013e328328d577

Identifying Cell‐Type‐Specific Metabolic Signatures Using Transcriptome and Proteome Analyses

Συγγραφείς: Gebert, Nadja, Rahman, Shahadat, Lewis, Caroline A., Ori, Alessandro, Cheng, Chia‐Wei

Πηγή: http://lobid.org/resources/99370710118806441#!, 1(9):e245.

Θεματικοί όροι: Transcriptome, Proteomics [MeSH], Proteome/genetics, Gene Expression Profiling, Transcriptome [MeSH], Gene Expression Profiling [MeSH], Metabolic Networks and Pathways/genetics [MeSH], Proteome/genetics [MeSH], Metabolic Networks and Pathways/genetics, Proteomics

Relation: https://repository.publisso.de/resource/frl:6475620; https://doi.org/10.1002/cpz1.245; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722675/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6475620
https://doi.org/10.1002/cpz1.245
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722675/

Expression of recombinant enhanced green fluorescent protein provides insight into foreign gene‐expression differences between Mut+ and MutS strains of Pichia pastoris

Συγγραφείς: Chrispian W. Theron, Julio Berrios, Sébastien Steels, Samuel Telek, Renaud Lecler, Christian Rodriguez, Patrick Fickers

Πηγή: Yeast. 36:285-296

Θεματικοί όροι: 0301 basic medicine, MutS, Green Fluorescent Proteins, EGFP, Biotechnologie, Green Fluorescent Proteins/genetics, Pichia, 03 medical and health sciences, Bioreactors, Methanol/metabolism, Pichia pastoris, PAOX1, Biomass, MutS DNA Mismatch-Binding Protein/genetics, Recombinant Proteins/biosynthesis/genetics, 0303 health sciences, Metabolic Networks and Pathways/genetics, Methanol, Life sciences, MutS DNA Mismatch-Binding Protein, Recombinant Proteins, Phenotype, Sciences du vivant, Pichia/genetics/metabolism, Metabolic Networks and Pathways, Biotechnology

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/30912856
https://onlinelibrary.wiley.com/doi/10.1002/yea.3388
https://www.ncbi.nlm.nih.gov/pubmed/30912856
https://orbi.uliege.be/handle/2268/257275
https://pubag.nal.usda.gov/catalog/6471534
https://hdl.handle.net/2268/257275
https://doi.org/10.1002/yea.3388

Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

Συγγραφείς: Elsemman, Ibrahim E, Rodriguez Prado, Angelica, Grigaitis, Pranas, Garcia Albornoz, Manuel, Harman, Victoria, Holman, Stephen W, van Heerden, Johan, Bruggeman, Frank J, Bisschops, Mark M M, Sonnenschein, Nikolaus, Hubbard, Simon, Beynon, Rob, Daran-Lapujade, Pascale, Nielsen, Jens, Teusink, Bas

Πηγή: Elsemman, I E, Rodriguez Prado, A, Grigaitis, P, Garcia Albornoz, M, Harman, V, Holman, S W, van Heerden, J, Bruggeman, F J, Bisschops, M M M, Sonnenschein, N, Hubbard, S, Beynon, R, Daran-Lapujade, P, Nielsen, J & Teusink, B 2022, 'Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies', Nature Communications, vol. 13, no. 1, pp. 801. https://doi.org/10.1038/s41467-022-28467-6

Θεματικοί όροι: Fermentation, Gene Expression Regulation, Fungal, Glucose/metabolism, Metabolic Networks and Pathways/genetics, Mitochondria/metabolism, Proteome/metabolism, Proteomics, Saccharomyces cerevisiae/genetics, Saccharomyces cerevisiae Proteins/genetics, Yeasts/genetics

Διαθεσιμότητα: https://research.manchester.ac.uk/en/publications/7bbda30e-215f-4ea5-ae1c-57e52c3301d8
https://doi.org/10.1038/s41467-022-28467-6

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Συγγραφείς: Ligthart S, Vaez A, Vosa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Mace A, Sidore C, Trompet S, Mangino M, SabaterLleal M, Kemp JP, Abbasi A, Kacprowski T, Verweij N, Smith AV, Huang T, Marzi C, Feitosa MF, Lohman KK, Kleber ME, Milaneschi Y, Mueller C, Huq M, Vlachopoulou E, Lyytikainen LP, Oldmeadow C, Deelen J, Perola M, Zhao JH, Feenstra B, Alizadeh BZ, Boezen HM, Franke L, van der Harst P, Navis G, Rots M, Snieder H, Swertz M, Wolffenbuttel BHR, Wijmenga C, Amini M, Benjamin E, Chasman DI, Dehghan A, Ahluwalia TS, Meigs J, Tracy R, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Wilson JG, Psaty BM, Dupuis J, Prins B, Vaso U, Stathopoulou M, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Uitterlinden AG, Abdollahi M, Schnabel R, Schick UM, Nolte IM, Kraja A, Hsu YH, Tylee DS, Zwicker A, Uher R, DaveySmith G, Morrison AC, Hicks A, van Duijn CM, WardCaviness C, Boerwinkle E, Rotter J, Rice K, Lange L, de Geus E, Morris AP, Makela KM, Stacey D, Eriksson J, Frayling TM, Slagboom EP, Lahti J, Schraut KE, Fornage M, Suktitipat B, Chen WM, Li X, Nutile T, Malerba G, Luan J, Bak T, Schork N, Del Greco M F, Thiering E, Mahajan A, Marioni RE, Mihailov E, Ozel AB, Zhang W, Nethander M, Cheng YC, Aslibekyan S, Ang W, Gandin I, Yengo L, Portas L, Kooperberg C, Hofer E, Rajan KB, Schurmann C, den Hollander W, Zhao J, Draisma HHM, Ford I, Timpson N, Teumer A, Huang H, Wahl S, Liu Y, Huang J, Uh HW, Geller F, Joshi PK, Yanek LR, Trabetti E, Lehne B, Vozzi D, Verbanck M, Biino G, Saba Y, Meulenbelt I, O'Connell JR, Laakso M, Giulianini F, Magnusson PKE, Ballantyne CM, Hottenga JJ, Montgomery GW, Rivadineira F, Rueedi R, Steri M, Herzig KH, Stott DJ, Menni C, Franberg M, St Pourcain B, Felix SB, Pers TH, Bakker SJL, Kraft P, Peters A, Vaidya D, Delgado G, Smit JH, Grossmann V, Sinisalo J, Seppala I, Williams SR, Holliday EG, Moed M, Langenberg C, Raikkonen K, Ding J, Campbell H, Sale MM, Chen YDI, James AL, Ruggiero D, Soranzo N, Hartman CA, Smith EN, Berenson GS, Fuchsberger C, Hernandez D, Tiesler CMT, Giedraitis V, Liewald D, Fischer K, Mellstrom D, Larsson A, Wang Y, Scott WR, Lorentzon M, Beilby J, Ryan KA, Pennell CE, Vuckovic D, Balkau B, Concas MP, Schmidt R, Mendes de Leon CF, Bottinger EP, Kloppenburg M, Paternoster L, Boehnke M, Musk AW, Willemsen G, Evans DM, Madden PAF, Kahonen M, Kutalik Z, Zoledziewska M, Karhunen V, Kritchevsky SB, Sattar N, Lachance G, Clarke R, Harris TB, Raitakari OT, Attia JR, van Heemst D, Kajantie E, Sorice R, Gambaro G, Scott RA, Hicks AA, Ferrucci L, Standl M, Lindgren CM, Starr JM, Karlsson M, Lind L, Li JZ, Chambers JC, Mori TA, de Geus EJCN, Heath AC, Martin NG, Auvinen J, Buckley BM, de Craen AJM, Waldenberger M, Strauch K, Meitinger T, Scott RJ, McEvoy M, Beekman M, Bombieri C, Ridker PM, Mohlke KL, Pedersen NL, Boomsma DI, Whitfield JB, Strachan DP, Hofman A, Vollenweider P, Cucca F, Jarvelin MR, Jukema JW, Spector TD, Hamsten A, Zeller T, Nauck M, Gudnason V, Qi L, Grallert H, Borecki IB, Rotter JI, Marz W, Wild PS, Lokki ML, Boyle M, Salomaa V, Melbye M, Eriksson JG, Wilson JF, Penninx BWJH, Becker DM, Worrall BB, Gibson G, Krauss RM, Ciullo M, Zaza G, Wareham NJ, Oldehinkel AJ, Palmer LJ, Murray SS, Pramstaller PP, Bandinelli S, Heinrich J, Ingelsson E, Deary IJ, Magi R, Vandenput L, Desch KC, Kooner JS, Ohlsson C, Hayward C, Shuldiner AR, Arnett DK, Beilin LJ, Robino A, Froguel P, Pirastu M, Jess T, Loos RJF, Evans DA, Schmidt H, Smith GD, Slagboom PE, Tracy RP, VisvikisSiest S, Reiner AP, Bis JC, Franco OH, Benjamin EJ

Συνεισφορές: Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Mace, A., Sidore, C., Trompet, S., Mangino, M., Sabater-Lleal, M., Kemp, J. P., Abbasi, A., Kacprowski, T., Verweij, N., Smith, A. V., Huang, T., Marzi, C., Feitosa, M. F., Lohman, K. K., Kleber, M. E., Milaneschi, Y., Mueller, C., Huq, M., Vlachopoulou, E., Lyytikainen, L. -P., Oldmeadow, C., Deelen, J., Perola, M., Zhao, J. H., Feenstra, B., Alizadeh, B. Z., Boezen, H. M., Franke, L., van der Harst, P., Navis, G., Rots, M., Snieder, H., Swertz, M., Wolffenbuttel, B. H. R., Wijmenga, C., Amini, M., Benjamin, E., Chasman, D. I., Dehghan, A., Ahluwalia, T. S., Meigs, J., Tracy, R., Bis, J., Eiriksdottir, G., Pankratz, N., Gross, M., Rainer, A., Wilson, J. G., Psaty, B. M., Dupuis, J., Prins, B., Vaso, U., Stathopoulou, M., Lehtimaki, T., Koenig, W., Jamshidi, Y., Siest, S., Uitterlinden, A. G., Abdollahi, M., Schnabel, R., Schick, U. M., Nolte, I. M., Kraja, A., Hsu, Y. -H., Tylee, D. S., Zwicker, A., Uher, R., Davey-Smith, G., Morrison, A. C., Hicks, A., van Duijn, C. M., Ward-Caviness, C., Boerwinkle, E., Rotter, J., Rice, K., Lange, L., de Geus, E., Morris, A. P., Makela, K. M., Stacey, D., Eriksson, J., Frayling, T. M., Slagboom, E. P., Lahti, J., Schraut, K. E., Fornage, M., Suktitipat, B., Chen, W. -M., Li, X., Nutile, T., Malerba, G., Luan, J., Bak, T., Schork, N., Del Greco, M. F., Thiering, E., Mahajan, A., Marioni, R. E., Mihailov, E., Ozel, A. B., Zhang, W., Nethander, M., Cheng, Y. -C., Aslibekyan, S., Ang, W., Gandin, I., Yengo, L., Portas, L., Kooperberg, C., Hofer, E., Rajan, K. B., Schurmann, C., den Hollander, W., Zhao, J., Draisma, H. H. M., Ford, I., Timpson, N., Teumer, A., Huang, H., Wahl, S., Liu, Y., Huang, J., Uh, H. -W., Geller, F., Joshi, P. K., Yanek, L. R., Trabetti, E., Lehne, B., Vozzi, D., Verbanck, M., Biino, G., Saba, Y., Meulenbelt, I., O'Connell, J. R., Laakso, M., Giulianini, F., Magnusson, P. K. E., Ballantyne, C. M., Hottenga, J. J., Montgomery, G. W., Rivadineira, F., Rueedi, R., Steri, M., Herzig, K. -H., Stott, D. J., Menni, C., Franberg, M., S, t. Pourcain B., Felix, S. B., Pers, T. H., Bakker, S. J. L., Kraft, P., Peters, A., Vaidya, D., Delgado, G., Smit, J. H., Grossmann, V., Sinisalo, J., Seppala, I., Williams, S. R., Holliday, E. G., Moed, M., Langenberg, C., Raikkonen, K., Ding, J., Campbell, H., Sale, M. M., Chen, Y. -D. I., James, A. L., Ruggiero, D., Soranzo, N., Hartman, C. A., Smith, E. N., Berenson, G. S., Fuchsberger, C., Hernandez, D., Tiesler, C. M. T., Giedraitis, V., Liewald, D., Fischer, K., Mellstrom, D., Larsson, A., Wang, Y., Scott, W. R., Lorentzon, M., Beilby, J., Ryan, K. A., Pennell, C. E., Vuckovic, D., Balkau, B., Concas, M. P., Schmidt, R., Mendes de Leon, C. F., Bottinger, E. P., Kloppenburg, M., Paternoster, L., Boehnke, M., Musk, A. W., Willemsen, G., Evans, D. M., Madden, P. A. F., Kahonen, M., Kutalik, Z., Zoledziewska, M., Karhunen, V., Kritchevsky, S. B., Sattar, N., Lachance, G., Clarke, R., Harris, T. B., Raitakari, O. T., Attia, J. R., van Heemst, D., Kajantie, E., Sorice, R., Gambaro, G., Scott, R. A., Hicks, A. A., Ferrucci, L., Standl, M., Lindgren, C. M., Starr, J. M., Karlsson, M., Lind, L., Li, J. Z., Chambers, J. C., Mori, T. A., de Geus, E. J. C. N., Heath, A. C., Martin, N. G., Auvinen, J., Buckley, B. M., de Craen, A. J. M., Waldenberger, M., Strauch, K., Meitinger, T., Scott, R. J., Mcevoy, M., Beekman, M., Bombieri, C., Ridker, P. M., Mohlke, K. L., Pedersen, N. L., Boomsma, D. I., Whitfield, J. B., Strachan, D. P., Hofman, A., Vollenweider, P., Cucca, F., Jarvelin, M. -R., Jukema, J. W., Spector, T. D., Hamsten, A., Zeller, T., Nauck, M., Gudnason, V., Qi, L., Grallert, H., Borecki, I. B., Rotter, J. I., Marz, W., Wild, P. S., Lokki, M. -L., Boyle, M., Salomaa, V., Melbye, M., Eriksson, J. G., Wilson, J. F., Penninx, B. W. J. H., Becker, D. M., Worrall, B. B., Gibson, G., Krauss, R. M., Ciullo, M., Zaza, G., Wareham, N. J., Oldehinkel, A. J., Palmer, L. J., Murray, S. S., Pramstaller, P. P., Bandinelli, S., Heinrich, J., Ingelsson, E., Deary, I. J., Magi, R., Vandenput, L., Desch, K. C., Kooner, J. S., Ohlsson, C., Hayward, C., Shuldiner, A. R., Arnett, D. K., Beilin, L. J., Robino, A., Froguel, P., Pirastu, M., Jess, T., Loos, R. J. F., Evans, D. A., Schmidt, H., Slagboom, P. E., Tracy, R. P., Visvikis-Siest, S., Reiner, A. P., Bis, J. C., Franco, O. H., Benjamin, E. J., Erasmus University Medical Center [Rotterdam] (Erasmus MC), University Medical Center Groningen [Groningen] (UMCG), University of Isfahan, University of Tartu, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), The University of Texas Health Science Center at Houston (UTHealth), National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda, MD, USA] (NIH), Brigham and Women's Hospital [Boston], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet [Stockholm], University of Split, Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Process & Energy Laboratory, Delft University of Technology (TU Delft), Grand Lyon : communauté urbaine de Lyon, Interuniversity Cardiology Institute Netherlands, King‘s College London, Huazhong University of Science and Technology [Wuhan] (HUST), Division of Statistical Genomics, Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL)-Washington University in Saint Louis (WUSTL), Department of Psychiatry, VU University Medical Center [Amsterdam], Institut fuer Theoretische Physik (Institut fuer Theoretische Physik), Universität Heidelberg [Heidelberg] = Heidelberg University, Molecular Epidemiology, MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Mahidol University [Bangkok], Northwest A and F University, Laboratoire d'Optimisation des Systèmes Industriels (LOSI), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Institute of Genetics and Biophysics, CNR, Naples, Università degli studi di Verona = University of Verona (UNIVR), Department of Molecular Medicine [Scripps Research Institute], The Scripps Research Institute [La Jolla, San Diego], Department of Physics, Indian Institute of Technology Kanpur (IIT Kanpur), Deptartment of Medical Biochemistry and Microbiology, Uppsala University, Department of Electrical and Computer Engineering [Waterloo] (ECE), University of Waterloo [Waterloo], University of Maryland School of Medicine, University of Maryland System, Institut National de l'Environnement Industriel et des Risques (INERIS), Institute of Pop. Genetics, CNR, Sassari, Interfaculty Institute for Genetics and Functional Genomics, Universität Greifswald - University of Greifswald, IT University of Copenhagen (ITU), Robertson Centre for Biostatistics, University of Glasgow, Centre for Causal Analyses in Translational Epidemiology, University of Bristol [Bristol]-Medical Research Council, Jinan University [Guangzhou], Institute of Oceanology [China], School Medicine, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), General Internal Medicine, Johns Hopkins School of Medicine, Johns Hopkins University School of Medicine [Baltimore], Shardna life science Pula Cagliari, Section Molecular Epidemiology, Leiden University Medical Center (LUMC), Department of Medicine, University of Eastern Finland-Kuopio University Hospital, Medstar Research Institute, Department of Cardiology, Ernst-Moritz-Arndt University, Center for Biological Sequence Analysis [Lyngby], Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Department of Internal Medicine, University of Groningen [Groningen], Department of Epidemiology, Harvard School of Public Health, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Metacohorts Consortium, INEOS Technologies (SWITZERLAND), MRC Epidemiology Unit, University of Cambridge [UK] (CAM)-Institute of Metabolic Science, University of Edinburgh (Edin.), School of Population Health [Crawley, Western Australia], The University of Western Australia (UWA), Institute of Genetics and Biophysics, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), The Scripps Translational Science Institute and Scripps Health, Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, Centre for Population Health Sciences, Genomic Research Laboratory, Service of Infectious Disease, Hôpitaux Universitaires de Genève (HUG), Infectious diseases division, Department of internal medicine, Washington University in Saint Louis (WUSTL), Luleå University of Technology (LUT), Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Austrian Institute of Technology [Vienna] (AIT), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department of Rheumatology and Clinical Epidemiology, Leiden University Medical Center (LUMC), Department of Rheumatology and Clinical Epidemiology [Leiden University Medical Center] (LUMC), Leiden University Medical Center (LUMC), Universiteit Leiden = Leiden University -Universiteit Leiden = Leiden University -Leiden University Medical Center (LUMC), Universiteit Leiden = Leiden University -Universiteit Leiden = Leiden University, Department of Biostatistics and Center for Statistical Genetics, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, University of Virginia, Tampere University Hospital, Department of Medical Genetics, Université de Lausanne = University of Lausanne (UNIL), Department of Pathological Biochemistry, Royal Infirmary, Oxford University, University of Oxford, University of Newcastle [Callaghan, Australia] (UoN), Department of neurology, Institute of Metabolic Science, MRC, The Wellcome Trust Centre for Human Genetics [Oxford], Uppsala Universitet [Uppsala], QIMR Berghofer Medical Research Institute, Institute of Genetic Epidemiology [Neuherberg, Germany], Institute of Human Genetics, Helmholtz Zentrum München = German Research Center for Environmental Health, Schizophrenia Research Institute [Sydney], Department of Genetics, University of North Carolina System (UNC)-University of North Carolina System (UNC), Vrije Universiteit Brussel (VUB), Population Health Sciences and Education, St George's University of London, Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] (CHUV), Institute of Health Sciences and Biocenter Oulu, University of Oulu, Medizinische Klinik und Poliklinik, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Institute of Clinical Chemistry and Laboratory Medicine, Icelandic Heart Association, Heart Preventive Clinic and Research Institute, Departments of Epidemiology and Nutrition, Institute of Epidemiology [Neuherberg] (EPI), Medical University Graz, Transplantation Laboratory [Helsinki], Haartman Institute [Helsinki], Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Department of Chronic Disease Prevention, National Institute for Health and Welfare [Helsinki], Dept. of Epidemiology Research, Statens Serum Institut [Copenhagen], CLinical Psychology, Genetics and Pathology, Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Center For Narcolepsy, Stanford University, Centre for Bone and Arthritis Research, Göteborgs Universitet = University of Gothenburg (GU)-Institute of Medicine, MRC Human Gentics Unit, Inst Genet and Mol Med, Western General Hospital, Edinburgh, University of Maryland School of Medicine [Baltimore, MD, USA], Génétique des maladies multifactorielles (GMM), Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Department of Physics [Stockholm], Stockholm University, University of Bristol [Bristol], Universiteit Leiden = Leiden University, Department of Epidemiology, University of Washington, University of Washington [Seattle], Department of Epidemiology [Rotterdam], Dutch Initiative on Crohn and Colitis (ICC), Icelandic Heart Association [Kopavogur, Iceland] (IHA), Department of Physiology and Biophysics [Jackson, MS, USA], University of Southern Mississippi (USM), Human Genetics Branch, National Institute of Mental Health (NIMH)-National Institutes of Health [Bethesda, MD, USA] (NIH), Faculty of Medicine and Life Sciences [Tampere], University of Tampere [Finland], German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), MRC Centre for Neuropsychiatric Genetics and Genomics, Medical Research Council-Cardiff University, Department of Social Medicine, School of Medicine [Los Angeles], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Department of Medicine [Aurora, CO, USA], University of Colorado [Denver], Institute for Molecular Medicine Finland [Helsinki] (FIMM), Helsinki Institute of Life Science (HiLIFE), Mathematical Institute [Oxford] (MI), Institute of Psychiatry, Psychology & Neuroscience, King's College London, DE CARVALHO, Philippe, LifeLines Cohort Study, CHARGE Inflammation Working Group, Bonnefond, Amelie, Ligthart, Symen, Vaez, Ahmad, Võsa, Urmo, Stathopoulou, Maria G, de Vries, Paul S, Prins, Bram P, Van der Most, Peter J, Tanaka, Toshiko, Naderi, Elnaz, Rose, Lynda M, Wu, Ying, Karlsson, Robert, Barbalic, Maja, Lin, Honghuang, Pool, René, Zhu, Gu, Macé, Aurélien, Sidore, Carlo, Trompet, Stella, Mangino, Massimo, Sabater-Lleal, Maria, Kemp, John P, Abbasi, Ali, Kacprowski, Tim, Verweij, Niek, Smith, Albert V, Huang, Tao, Marzi, Carola, Feitosa, Mary F, Lohman, Kurt K, Kleber, Marcus E, Milaneschi, Yuri, Mueller, Christian, Huq, Mahmudul, Vlachopoulou, Efthymia, Lyytikäinen, Leo-Pekka, Oldmeadow, Christopher, Deelen, Jori, Perola, Marku, Zhao, Jing Hua, Feenstra, Bjarke, Amini, Marzyeh, Lahti, Jari, Schraut, Katharina E, Fornage, Myriam, Suktitipat, Bhoom, Chen, Wei-Min, Li, Xiaohui, Nutile, Teresa, Malerba, Giovanni, Luan, Jian'An, Bak, Tom, Schork, Nichola, Del Greco M, Fabiola, Thiering, Elisabeth, Mahajan, Anubha, Marioni, Riccardo E, Mihailov, Evelin, Eriksson, Joel, Ozel, Ayse Bilge, Zhang, Weihua, Nethander, Maria, Cheng, Yu-Ching, Aslibekyan, Stella, Ang, Wei, Gandin, Ilaria, Yengo, Loïc, Portas, Laura, Kooperberg, Charle, Hofer, Edith, Rajan, Kumar B, Schurmann, Claudia, den Hollander, Wouter, Ahluwalia, Tarunveer S, Zhao, Jing, Draisma, Harmen H M, Ford, Ian, Timpson, Nichola, Teumer, Alexander, Huang, Hongyan, Wahl, Simone, Liu, Yongmei, Huang, Jie, Uh, Hae-Won, Geller, Frank, Joshi, Peter K, Yanek, Lisa R, Trabetti, Elisabetta, Lehne, Benjamin, Vozzi, Diego, Verbanck, Marie, Biino, Ginevra, Saba, Yasaman, Meulenbelt, Ingrid, O'Connell, Jeff R, Laakso, Markku, Giulianini, Franco, Magnusson, Patrik K E, Ballantyne, Christie M, Hottenga, Jouke Jan

Πηγή: AMERICAN JOURNAL OF HUMAN GENETICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
American journal of human genetics 103 (2018): 691–706. doi:10.1016/j.ajhg.2018.09.009
info:cnr-pdr/source/autori:Ligthart S.; Vaez A.; Vosa U.; Stathopoulou M.G.; de Vries P.S.; Prins B.P.; Van der Most P.J.; Tanaka T.; Naderi E.; Rose L.M.; Wu Y.; Karlsson R.; Barbalic M.; Lin H.; Pool R.; Zhu G.; Mace A.; Sidore C.; Trompet S.; Mangino M.; Sabater-Lleal M.; Kemp J.P.; Abbasi A.; Kacprowski T.; Verweij N.; Smith A.V.; Huang T.; Marzi C.; Feitosa M.F.; Lohman K.K.; Kleber M.E.; Milaneschi Y.; Mueller C.; Huq M.; Vlachopoulou E.; Lyytikainen L.-P.; Oldmeadow C.; Deelen J.; Perola M.; Zhao J.H.; Feenstra B.; Alizadeh B.Z.; Boezen H.M.; Franke L.; van der Harst P.; Navis G.; Rots M.; Snieder H.; Swertz M.; Wolffenbuttel B.H.R.; Wijmenga C.; Amini M.; Benjamin E.; Chasman D.I.; Dehghan A.; Ahluwalia T.S.; Meigs J.; Tracy R.; Alizadeh B.Z.; Ligthart S.; Bis J.; Eiriksdottir G.; Pankratz N.; Gross M.; Rainer A.; Snieder H.; Wilson J.G.; Psaty B.M.; Dupuis J.; Prins B.; Vaso U.; Stathopoulou M.; Franke L.; Lehtimaki T.; Koenig W.; Jamshidi Y.; Siest S.; Abbasi A.; Uitterlinden A.G.; Abdollahi M.; Schnabel R.; Schick U.M.; Nolte I.M.; Kraja A.; Hsu Y.-H.; Tylee D.S.; Zwicker A.; Uher R.; Davey-Smith G.; Morrison A.C.; Hicks A.; van Duijn C.M.; Ward-Caviness C.; Boerwinkle E.; Rotter J.; Rice K.; Lange L.; Perola M.; de Geus E.; Morris A.P.; Makela K.M.; Stacey D.; Eriksson J.; Frayling T.M.; Slagboom E.P.; Lahti J.; Schraut K.E.; Fornage M.; Suktitipat B.; Chen W.-M.; Li X.; Nutile T.; Malerba G.; Luan J.; Bak T.; Schork N.; Del Greco M. F.; Thiering E.; Mahajan A.; Marioni R.E.; Mihailov E.; Eriksson J.; Ozel A.B.; Zhang W.; Nethander M.; Cheng Y.-C.; Aslibekyan S.; Ang W.; Gandin I.; Yengo L.; Portas L.; Kooperberg C.; Hofer E.; Rajan K.B.; Schurmann C.; den Hollander W.; Ahluwalia T.S.; Zhao J.; Draisma H.H.M.; Ford I.; Timpson N.; Teumer A.; Huang H.; Wahl S.; Liu Y.; Huang J.; Uh H.-W.; Geller F.; Joshi P.K.; Yanek L.R.; Trabetti E.; Lehne B.; Vozzi D.; Verbanck M.; Biino G.; Saba Y.; Meulenbelt I.; O'Connell J.R.; Laakso M.; Giulianini F.; Magnusson P.K.E.; Ballantyne C.M.; Hottenga J.J.; Montgomery G.W.; Rivadineira F.; Rueedi R.; Steri M.; Herzig K.-H.; Stott D.J.; Menni C.; Franberg M.; St. Pourcain B.; Felix S.B.; Pers T.H.; Bakker S.J.L.; Kraft P.; Peters A.; Vaidya D.; Delgado G.; Smit J.H.; Grossmann V.; Sinisalo J.; Seppala I.; Williams S.R.; Holliday E.G.; Moed M.; Langenberg C.; Raikkonen K.; Ding J.; Campbell H.; Sale M.M.; Chen Y.-D.I.; James A.L.; Ruggiero D.; Soranzo N.; Hartman C.A.; Smith E.N.; Berenson G.S.; Fuchsberger C.; Hernandez D.; Tiesler C.M.T.; Giedraitis V.; Liewald D.; Fischer K.; Mellstrom D.; Larsson A.; Wang Y.; Scott W.R.; Lorentzon M.; Beilby J.; Ryan K.A.; Pennell C.E.; Vuckovic D.; Balkau B.; Concas M.P.; Schmidt R.; Mendes de Leon C.F.; Bottinger E.P.; Kloppenburg M.; Paternoster L.; Boehnke M.; Musk A.W.; Willemsen G.; Evans D.M.; Madden P.A.F.; Kahonen M.; Kutalik Z.; Zoledziewska M.; Karhunen V.; Kritchevsky S.B.; Sattar N.; Lachance G.; Clarke R.; Harris T.B.; Raitakari O.T.; Attia J.R.; van Heemst D.; Kajantie E.; Sorice R.; Gambaro G.; Scott R.A.; Hicks A.A.; Ferrucci L.; Standl M.; Lindgren C.M.; Starr J.M.; Karlsson M.; Lind L.; Li J.Z.; Chambers J.C.; Mori T.A.; de Geus E.J.C.N.; Heath A.C.; Martin N.G.; Auvinen J.; Buckley B.M.; de Craen A.J.M.; Waldenberger M.; Strauch K.; Meitinger T.; Scott R.J.; McEvoy M.; Beekman M.; Bombieri C.; Ridker P.M.; Mohlke K.L.; Pedersen N.L.; Morrison A.C.; Boomsma D.I.; Whitfield J.B.; Strachan D.P.; Hofman A.; Vollenweider P.; Cucca F.; Jarvelin M.-R.; Jukema J.W.; Spector T.D.; Hamsten A.; Zeller T.; Uitterlinden A.G.; Nauck M.; Gudnason V.; Qi L.; Grallert H.; Borecki I.B.; Rotter J.I.; Marz W.; Wild P.S.; Lokki M.-L.; Boyle M.; Salomaa V.; Melbye M.; Eriksson J.G.; Wilson J.F.; Penninx B.W.J.H.; Becker D.M.; Worrall B.B.; Gibson G.; Krauss R.M.; Ciullo M.; Zaza G.; Wareham N.J.; Oldehinkel A.J.; Palmer L.J.; Murray S.S.; Pramstaller P.P.; Bandinelli S.; Heinrich J.; Ingelsson E.; Deary I.J.; Magi R.; Vandenput L.; van der Harst P.; Desch K.C.; Kooner J.S.; Ohlsson C.; Hayward C.; Lehtimaki T.; Shuldiner A.R.; Arnett D.K.; Beilin L.J.; Robino A.; Froguel P.; Pirastu M.; Jess T.; Koenig W.; Loos R.J.F.; Evans D.A.; Schmidt H.; Smith G.D.; Slagboom P.E.; Eiriksdottir G.; Morris A.P.; Psaty B.M.; Tracy R.P.; Nolte I.M.; Boerwinkle E.; Visvikis-Siest S.; Reiner A.P.; Gross M.; Bis J.C.; Franke L.; Franco O.H.; Benjamin E.J.; Chasman D.I.; Dupuis J.; Snieder H.; Dehghan A.; Alizadeh B.Z./titolo:Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders/doi:10.1016%2Fj.ajhg.2018.09.009/rivista:American journal of human genetics/anno:2018/pagina_da:691/pagina_a:706/intervallo_pagine:691–706/volume:103
American Journal of Human Genetics
American Journal of Human Genetics, 2018, 103 (5), pp.691-706. ⟨10.1016/j.ajhg.2018.09.009⟩
Lifelines Cohort Study 2018, 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders', American journal of human genetics, vol. 103, no. 5, pp. 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009
The American Journal of Human Genetics
Ligthart, S, Vaez, A, Võsa, U, Stathopoulou, M G, de Vries, P S, Prins, B P, Van der Most, P J, Tanaka, T, Naderi, E, Rose, L M, Wu, Y, Karlsson, R, Barbalic, M, Lin, H, Pool, R, Zhu, G, Macé, A, Sidore, C, Trompet, S, Mangino, M, Sabater-Lleal, M, Kemp, J P, Abbasi, A, Kacprowski, T, Verweij, N, Smith, A V, Huang, T, Marzi, C, Feitosa, M F, Lohman, K K, Kleber, M E, Milaneschi, Y, Mueller, C, Huq, M, Vlachopoulou, E, Lyytikäinen, L P, Oldmeadow, C, Deelen, J, Perola, M, Zhao, J, Davey-Smith, G, Hicks, A, Timpson, N, St. Pourcain, B, Soranzo, N, Paternoster, L, Evans, D M & Hicks, A & Palmer, L J & Davey-Smith, G 2018, 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders', American Journal of Human Genetics, vol. 103, no. 5, pp. 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009
LifeLines Cohort Study 2018, 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders', American Journal of Human Genetics, vol. 103, no. 5, pp. 691-706. https://doi.org/10.1016/j.ajhg.2018.09.009
American Journal of Human Genetics, vol 103, iss 5

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Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response

Συγγραφείς: Susann Matthes, Valentina Mosienko, Robson A.S. Santos, Mihail Todiras, Michael Bader, Friederike Klempin, Daniel C. Villela, Natalia Alenina, Josef M. Penninger

Πηγή: Cell Mol Life Sci

Θεματικοί όροι: 0301 basic medicine, Serotonin, Knockout, Neurogenesis, Cell Differentiation/genetics, 5-HT, Down-Regulation, Peptidyl-Dipeptidase A/genetics, Peptidyl-Dipeptidase A, Inbred C57BL, Hippocampus, Serotonin/metabolism, Running, Cell Proliferation/genetics, Mice, 03 medical and health sciences, Animal/physiology, Neurobiology, Neural Stem Cells, Physical Conditioning, Animal, Brain/metabolism, Animals, Adult Stem Cells/physiology, BrdU, Cell Proliferation, Mice, Knockout, 0303 health sciences, Neural Stem Cells/physiology, Animal, Metabolic Networks and Pathways/genetics, Physical exercise, Brain, Cell Differentiation, Running/physiology, Down-Regulation/genetics, Physical Conditioning, 3. Good health, Mice, Inbred C57BL, Adult Stem Cells, Cardiovascular and Metabolic Diseases, Original Article, Female, Angiotensin-Converting Enzyme 2, Neurogenesis/genetics, Gene Deletion, Metabolic Networks and Pathways

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc7079801?pdf=render
https://pubmed.ncbi.nlm.nih.gov/29679094
https://link.springer.com/content/pdf/10.1007%2Fs00018-018-2815-y.pdf
https://pubmed.ncbi.nlm.nih.gov/29679094/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079801
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https://www.ncbi.nlm.nih.gov/pubmed/29679094
https://rd.springer.com/article/10.1007/s00018-018-2815-y
http://edoc.mdc-berlin.de/17371/1/17371oa.pdf

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Συγγραφείς: Mijnheer, Gerdien, Lutter, Lisanne, Mokry, Michal, van der Wal, Marlot, Scholman, Rianne, Fleskens, Veerle, Pandit, Aridaman, Tao, Weiyang, Wekking, Mark, Vervoort, Stephin, Roberts, Ceri, Petrelli, Alessandra, Peeters, Janneke G C, Knijff, Marthe, de Roock, Sytze, Vastert, Sebastiaan, Taams, Leonie S, van Loosdregt, Jorg, van Wijk, Femke

Συνεισφορές: Infection & Immunity, MMB-imm, CTI Van Wijk, Onderzoek Precision medicine, Child Health, Circulatory Health, CTI Van Loosdregt, CTI Pandit, Lab Reumatologie/Klinische Immunologie, CTI Research, CMM Groep Coffer, Immuno/reuma onderzoek 1 (Vastert), Immuno/reuma onderzoek 5 (Vastert2), Immuno/reuma onderzoek 3 (Loosdregt)

Θεματικοί όροι: Adolescent, Arthritis, Juvenile/genetics, Base Sequence, Basic-Leucine Zipper Transcription Factors/genetics, CTLA-4 Antigen/genetics, Case-Control Studies, Cell Differentiation, Child, Preschool, Epigenesis, Genetic, Female, Forkhead Transcription Factors/genetics, Gene Expression Profiling, Gene Regulatory Networks, Glucocorticoid-Induced TNFR-Related Protein/genetics, Histones/genetics, Humans, Joints/immunology, Male, Metabolic Networks and Pathways/genetics, Positive Regulatory Domain I-Binding Factor 1/genetics, Primary Cell Culture, Receptors, Calcitriol/genetics, Immunologic/genetics, T-Lymphocytes, Regulatory/immunology, Transcriptome

Περιγραφή αρχείου: application/pdf

Relation: https://dspace.library.uu.nl/handle/1874/443104

Διαθεσιμότητα: https://dspace.library.uu.nl/handle/1874/443104

COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms.

Συγγραφείς: Ostaszewski, Marek, Niarakis, Anna, Ruepp, Andreas, Soliman, Sylvain, Valdeolivas, Alberto, Esteban-Medina, Marina, Peña-Chilet, Maria, Rian, Kinza, Helikar, Tomáš, Puniya, Bhanwar Lal, Modos, Dezso, Treveil, Agatha, Olbei, Marton, Fobo, Gisela, De Meulder, Bertrand, Ballereau, Stephane, Dugourd, Aurélien, Naldi, Aurélien, Noël, Vincent, Calzone, Laurence, Sander, Chris, Demir, Emek, Korcsmaros, Tamas, Freeman, Tom C, Montrone, Corinna, Augé, Franck, Beckmann, Jacques S, Hasenauer, Jan, Wolkenhauer, Olaf, Wilighagen, Egon L, Pico, Alexander R, Evelo, Chris T, Gillespie, Marc E, Stein, Lincoln D, Hermjakob, Henning, Brauner, Barbara, D'Eustachio, Peter, Saez-Rodriguez, Julio, Dopazo, Joaquin, Valencia, Alfonso, Kitano, Hiroaki, Barillot, Emmanuel, Auffray, Charles, Balling, Rudi, Schneider, Reinhard, Community, COVID-19 Disease Map, Frishman, Goar, Monraz Gómez, Luis Cristóbal, Somers, Julia, Hoch, Matti, Kumar Gupta, Shailendra, Scheel, Julia, Mazein, Alexander, Borlinghaus, Hanna, Czauderna, Tobias, Schreiber, Falk, Montagud, Arnau, Ponce de Leon, Miguel, Funahashi, Akira, Hiki, Yusuke, Hiroi, Noriko, Yamada, Takahiro G, Dräger, Andreas, Kuperstein, Inna, Renz, Alina, Naveez, Muhammad, Bocskei, Zsolt, Messina, Francesco, Börnigen, Daniela, Fergusson, Liam, Conti, Marta, Rameil, Marius, Nakonecnij, Vanessa, Vanhoefer, Jakob, Phair, Robert, Schmiester, Leonard, Wang, Muying, Ackerman, Emily E, Shoemaker, Jason E, Zucker, Jeremy, Oxford, Kristie, Teuton, Jeremy, Kocakaya, Ebru, Summak, Gökçe Yağmur, Hanspers, Kristina, Orta-Resendiz, Aurelio, Kutmon, Martina, Coort, Susan, Eijssen, Lars, Ehrhart, Friederike, Rex, Devasahayam Arokia Balaya, Slenter, Denise, Martens, Marvin, Pham, Nhung, Haw, Robin, Jassal, Bijay, Singh, Vidisha, Matthews, Lisa, Orlic-Milacic, Marija, Senff Ribeiro, Andrea, Rothfels, Karen, Shamovsky, Veronica, Stephan, Ralf, Sevilla, Cristoffer, Varusai, Thawfeek, Ravel, Jean-Marie, Fraser, Rupsha, Aghamiri, Sara Sadat, Ortseifen, Vera, Marchesi, Silvia, Gawron, Piotr, Smula, Ewa, Heirendt, Laurent, Satagopam, Venkata, Wu, Guanming, Riutta, Anders, Golebiewski, Martin, Owen, Stuart, Acencio, Marcio Luis, Goble, Carole, Hu, Xiaoming, Overall, Rupert, Maier, Dieter, Bauch, Angela, Gyori, Benjamin M, Bachman, John A, Vega, Carlos, Grouès, Valentin, Vazquez, Miguel, Glaab, Enrico, Porras, Pablo, Licata, Luana, Iannuccelli, Marta, Sacco, Francesca, Nesterova, Anastasia, Yuryev, Anton, de Waard, Anita, Turei, Denes, Luna, Augustin, Babur, Ozgun

Πηγή: Molecular systems biology 17(10), e10387 (2021). doi:10.15252/msb.202110387

Θεματικοί όροι: info:eu-repo/classification/ddc/570, COVID-19 Drug Treatment, Antiviral Agents: therapeutic use, COVID-19: drug therapy, COVID-19: genetics, COVID-19: immunology, COVID-19: virology, Computational Biology: methods, Computer Graphics, Cytokines: genetics, Cytokines: immunology, Data Mining: statistics & numerical data, Databases, Factual, Gene Expression Regulation, Host Microbial Interactions: genetics, Host Microbial Interactions: immunology, Humans, Immunity, Cellular: drug effects, Humoral: drug effects, Innate: drug effects, Lymphocytes: drug effects, Lymphocytes: immunology, Lymphocytes: virology, Metabolic Networks and Pathways: genetics, Metabolic Networks and Pathways: immunology, Myeloid Cells: drug effects, Myeloid Cells: immunology, Myeloid Cells: virology

Θέμα γεωγραφικό: DE

Relation: info:eu-repo/semantics/altIdentifier/issn/1744-4292; info:eu-repo/semantics/altIdentifier/pmid/pmid:34664389; https://pub.dzne.de/record/162909

Διαθεσιμότητα: https://pub.dzne.de/record/162909
https://pub.dzne.de/search?p=id:%22DZNE-2021-01564%22

Conserved human effector Treg cell transcriptomic and epigenetic signature in arthritic joint inflammation

Συγγραφείς: Gerdien Mijnheer, Lisanne Lutter, Michal Mokry, Marlot van der Wal, Rianne Scholman, Veerle Fleskens, Aridaman Pandit, Weiyang Tao, Mark Wekking, Stephin Vervoort, Ceri Roberts, Alessandra Petrelli, Janneke G. C. Peeters, Marthe Knijff, Sytze de Roock, Sebastiaan Vastert, Leonie S. Taams, Jorg van Loosdregt, Femke van Wijk

Συνεισφορές: Infection & Immunity, MMB-imm, CTI Van Wijk, Onderzoek Precision medicine, Child Health, Circulatory Health, CTI Van Loosdregt, CTI Pandit, Lab Reumatologie/Klinische Immunologie, CTI Research, CMM Groep Coffer, Immuno/reuma onderzoek 1 (Vastert), Immuno/reuma onderzoek 5 (Vastert2), Immuno/reuma onderzoek 3 (Loosdregt)

Πηγή: Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Θεματικοί όροι: Male, Joints/immunology, Adolescent, Positive Regulatory Domain I-Binding Factor 1/genetics, Arthritis, Juvenile/genetics, Science, Primary Cell Culture, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy, T-Lymphocytes, Regulatory/immunology, Receptors, Calcitriol/genetics, Article, Epigenesis, Genetic, Histones, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Glucocorticoid-Induced TNFR-Related Protein, Journal Article, Humans, CTLA-4 Antigen, Gene Regulatory Networks, Forkhead Transcription Factors/genetics, Child, Glucocorticoid-Induced TNFR-Related Protein/genetics, Histones/genetics, Base Sequence, Receptors, Immunologic/genetics, Metabolic Networks and Pathways/genetics, Research Support, Non-U.S. Gov't, Gene Expression Profiling, Basic-Leucine Zipper Transcription Factors/genetics, Cell Differentiation, Forkhead Transcription Factors, General Chemistry, Arthritis, Juvenile, Basic-Leucine Zipper Transcription Factors, Case-Control Studies, Child, Preschool, CTLA-4 Antigen/genetics, Female, Joints, Transcriptome, Metabolic Networks and Pathways

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41467-021-22975-7.pdf
https://pubmed.ncbi.nlm.nih.gov/33976194
https://doaj.org/article/0a5628b633d646d0b5877f5920381df7
https://pubmed.ncbi.nlm.nih.gov/33976194/
https://www.nature.com/articles/s41467-021-22975-7
http://ui.adsabs.harvard.edu/abs/2021NatCo..12.2710M/abstract
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113485
https://www.nature.com/articles/s41467-021-22975-7.pdf
https://europepmc.org/article/MED/33976194
https://dspace.library.uu.nl/handle/1874/443104
https://hdl.handle.net/2434/1059969
https://doi.org/10.1038/s41467-021-22975-7