Incorporating genetic data improves target trial emulations and informs the use of polygenic scores in randomized controlled trial design

Συγγραφείς: Jakob German, Zhiyu Yang, Sarah Urbut, Pekka Vartiainen, Andrea Gana, Pradeep Natarajan, Elisabetta Patorno, Zoltan Kutalik, Anthony Philippakis, Andrea Ganna

Συνεισφορές: Institute for Molecular Medicine Finland, University of Helsinki, Children's Hospital, HUS Children and Adolescents, Data Science Genetic Epidemiology Lab, FinnGen, Gana, A.

Πηγή: Nat Genet
Nature genetics, vol. 57, no. 7, pp. 1620-1627

Θεματικοί όροι: Cardiovascular outcomes, Biomedicine, Propensity score, Genetics, developmental biology, physiology, Humans, Multifactorial Inheritance/genetics, Randomized Controlled Trials as Topic/methods, Mendelian Randomization Analysis/methods, Research Design, Computer Simulation, Empagliflozin, Warfarin, Mortality, Article, Causal inference

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: http://hdl.handle.net/10138/599558
https://serval.unil.ch/resource/serval:BIB_4F42A4058C06.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4F42A4058C061
https://serval.unil.ch/notice/serval:BIB_4F42A4058C06

Non-linear Mendelian randomization: evaluation of effect modification in the residual and doubly-ranked methods with simulated and empirical examples

Συγγραφείς: Fergus W. Hamilton, David A. Hughes, Tianyuan Lu, Zoltán Kutalik, Apostolos Gkatzionis, Kate Tilling, Fernando P. Hartwig, George Davey Smith

Πηγή: Eur J Epidemiol
European journal of epidemiology, vol. 40, no. 6, pp. 631-647

Θεματικοί όροι: Mendelian Randomization, name=Bristol Population Health Science Institute, Mendelian Randomization Analysis/methods, Humans, Bias, Computer Simulation, Causality, Nonlinear Dynamics, Genotype, Biostatistics, Mendelian randomisation, Methods, NLMR

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://serval.unil.ch/resource/serval:BIB_421BB036B896.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_421BB036B8960
https://serval.unil.ch/notice/serval:BIB_421BB036B896

MR-link-2: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality: pleiotropy robust cis Mendelian randomization validated in three independent reference datasets of causality

Συγγραφείς: Adriaan van der Graaf, Robert Warmerdam, Chiara Auwerx, Toni Boltz, Dorret I. Boomsma, Andrew Brown, Evans Cheruiyot, Emma E. Davenport, Théo Dupuis, Tõnu Esko, Aiman Farzeen, Luigi Ferrucci, Timothy M. Frayling, Greg Gibson, Christian Gieger, Marleen van Greevenbroek, Binisha Hamal Mishra, M. Arfan Ikram, Michael Inouye, Rick Jansen, Mika Kähönen, Viktorija Kukushkina, Sandra Lapinska, Terho Lehtimäki, Reedik Mägi, Angel Martinez-Perez, Allan F. McRae, Joyce van Meurs, Lili Milani, Grant W. Montgomery, Sini Nagpal, Matthias Nauck, Roel Ophoff, Bogdan Pasaniuc, Dirk S. Paul, Elodie Persyn, Annette Peters, Holger Prokisch, Olli T. Raitakari, Emma Raitoharju, Andrew Singleton, Eline Slagboom, José Manuel Soria, Juan Carlos Souto, Alexander Teumer, Alex Tokolyi, Jan Veldink, Joost Verlouw, Ana Viñuela, Peter M. Visscher, Uwe Völker, Stefan Weiss, Harm-Jan Westra, Andrew R. Wood, Manke Xie, Urmo Võsa, Maria Carolina Borges, Lude Franke, Zoltán Kutalik

Συνεισφορές: eQTLGen Consortium, Boltz, T., Boomsma, D.I., Brown, A., Cheruiyot, E., Davenport, E.E., Dupuis, T., Esko, T., Farzeen, A., Ferrucci, L., Frayling, T.M., Gibson, G., Gieger, C., van Greevenbroek, M., Mishra, B.H., Ikram, M.A., Inouye, M., Jansen, R., Kähönen, M., Kukushkina, V., Lapinska, S., Lehtimäki, T., Mägi, R., Martinez-Perez, A., McRae, A.F., van Meurs, J., Milani, L., Montgomery, G.W., Nagpal, S., Nauck, M., Ophoff, R., Pasaniuc, B., Paul, D.S., Persyn, E., Peters, A., Prokisch, H., Raitakari, O.T., Raitoharju, E., Singleton, A., Slagboom, E., Soria, J.M., Souto, J.C., Teumer, A., Tokolyi, A., Veldink, J., Verlouw, J., Viñuela, A., Visscher, P.M., Völker, U., Weiss, S., Westra, H.J., Wood, A.R., Xie, M.

Πηγή: Nat Commun
Nature communications, vol. 16, no. 1, pp. 6112

Θεματικοί όροι: Mendelian Randomization Analysis/methods, Genetic Pleiotropy, Humans, Quantitative Trait Loci, Linkage Disequilibrium, Causality, Computer Simulation, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Metabolic Networks and Pathways/genetics, Article, ddc

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pure.eur.nl/en/publications/a64df5d4-8d0d-4245-bd8e-273e9b05f2c2
https://doi.org/10.1038/s41467-025-60868-1
https://serval.unil.ch/notice/serval:BIB_B36431D3CE3B
https://serval.unil.ch/resource/serval:BIB_B36431D3CE3B.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_B36431D3CE3B0
https://mediatum.ub.tum.de/1791958

Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study

Συγγραφείς: Konzok, Julian, Gorski, Mathias, Winkler, Thomas W., Baumeister, Sebastian E., Warrier, Varun, Leitzmann, Michael F., Baurecht, Hansjörg

Συνεισφορές: Apollo - University of Cambridge Repository

Πηγή: Mol Psychiatry

Θεματικοί όροι: Male, Conduct Disorder, 0301 basic medicine, ddc:610, Substance-Related Disorders, Antisocial Personality Disorder/epidemiology [MeSH], Antisocial Personality Disorder/genetics [MeSH], Risk Factors [MeSH], 692/699/476, Attention Deficit Disorder with Hyperactivity/genetics [MeSH], Polymorphism, Single Nucleotide/genetics [MeSH], Genome-Wide Association Study/methods [MeSH], Male [MeSH], Conduct Disorder/epidemiology [MeSH], 45/43, Child Abuse/psychology [MeSH], Phenotype [MeSH], Child [MeSH], Genetic Predisposition to Disease/genetics [MeSH], Substance-Related Disorders/psychology [MeSH], Gene-Environment Interaction [MeSH], Female [MeSH], Conduct Disorder/genetics [MeSH], 631/208, Humans [MeSH], 631/477, Article, Substance-Related Disorders/genetics [MeSH], Mendelian Randomization Analysis/methods [MeSH], article, 610 Medizin, Antisocial Personality Disorder, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, 3. Good health, 03 medical and health sciences, Phenotype, 0302 clinical medicine, Risk Factors, Attention Deficit Disorder with Hyperactivity, Humans, Female, Genetic Predisposition to Disease, Gene-Environment Interaction, Child Abuse, Child, Genome-Wide Association Study

Περιγραφή αρχείου: text/xml; application/zip; application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39174650
https://repository.publisso.de/resource/frl:6492158
https://epub.uni-regensburg.de/59015/

Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study: a mendelian randomization study

Συγγραφείς: Ortega N., Mueller N. J., Dehghan A., de Crom T. O. E., von Gunten A., Preisig M., Marques-Vidal P., Vinceti M., Voortman T., Rodondi N., Chocano-Bedoya P. O.

Πηγή: Nutr J
Nutrition Journal, Vol 24, Iss 1, Pp 1-10 (2025)
Nutrition journal, vol. 24, no. 1, pp. 20

Θεματικοί όροι: Male, Humans, Mendelian Randomization Analysis/methods, Cognition/physiology, Aged, Female, Dairy Products/statistics & numerical data, Middle Aged, Lactase/genetics, Cohort Studies, Netherlands, Diet/methods, Diet/statistics & numerical data, Longitudinal Studies, Canada, Genotype, CLSA, Cognitive function, Dairy, Lactase persistence, Mendelian randomization, RC620-627, Cognition, TX341-641, Nutritional diseases. Deficiency diseases, Lactase, Nutrition. Foods and food supply, Research, Mendelian Randomization Analysis, Diet, Dairy Products

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39891239
https://doaj.org/article/aa11d18a26904ce58d02f86d10d105a4
https://serval.unil.ch/resource/serval:BIB_4822D2C59E2D.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_4822D2C59E2D
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4822D2C59E2D9
https://hdl.handle.net/11380/1373048
https://doi.org/10.1186/s12937-025-01083-y

Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis

Συγγραφείς: Marina O. Rontogianni, Emmanouil Bouras, Elom Kouassivi Aglago, Heinz Freisling, Neil Murphy, Michelle Cotterchio, Jochen Hampe, Annika Lindblom, Rish K. Pai, Paul D. P. Pharoah, Amanda I. Phipps, Franzel J. B. van Duijnhoven, Kala Visvanathan, Bethany van Guelpen, Christopher I. Li, Hermann Brenner, Andrew J. Pellatt, Shuji Ogino, Marc J. Gunter, Ulrike Peters, Sofia Christakoudi, Konstantinos K. Tsilidis

Συνεισφορές: DSpace at Cambridge pro (8.1)

Πηγή: Int J Obes (Lond)

Θεματικοί όροι: Male, 2. Zero hunger, Cancer och onkologi, Waist-Hip Ratio, Female [MeSH], Waist-Hip Ratio [MeSH], Humans [MeSH], Waist Circumference [MeSH], Risk Factors [MeSH], Colorectal Neoplasms/epidemiology [MeSH], Body Mass Index [MeSH], Article, Male [MeSH], 692/499, Mendelian Randomization Analysis/methods [MeSH], 692/699/67, Colorectal Neoplasms/genetics [MeSH], article, Folkhälsovetenskap, global hälsa och socialmedicin, Mendelian Randomization Analysis, Public Health, Global Health and Social Medicine, Body Mass Index, 3. Good health, Risk Factors, Cancer and Oncology, Life Science, Humans, Female, Waist Circumference, Colorectal Neoplasms, 10. No inequality

Περιγραφή αρχείου: application/pdf; application/zip; text/xml

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38297030
https://repository.publisso.de/resource/frl:6500369
https://research.wur.nl/en/publications/allometric-versus-traditional-body-shape-indices-and-risk-of-colo
https://doi.org/10.1038/s41366-024-01479-6
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-220884

Managing the exponential growth of Mendelian randomization studies

Συγγραφείς: Marcus R Munafo, Jamie Brown, Marita Hefler, George Davey Smith

Πηγή: Nicotine Tob Res

Θεματικοί όροι: Editorial, Research Design, Humans, Mendelian Randomization Analysis/methods, Mendelian Randomization Analysis

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39313311
https://pubmed.ncbi.nlm.nih.gov/39308072
https://pubmed.ncbi.nlm.nih.gov/39311417

Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence

Συγγραφείς: Nielsen, Maria Booth, Çolak, Yunus, Benn, Marianne, Mason, Amy, Burgess, Stephen, Nordestgaard, Børge Grønne

Συνεισφορές: DSpace at Cambridge pro (8.1)

Πηγή: Cardiovascular Research. 120:95-107

Θεματικοί όροι: Heart Failure, Myocardial Infarction, Mendelian Randomization Analysis/methods, Heart failure, Single Nucleotide, Aortic Valve Stenosis, Aortic valve stenosis, Mendelian Randomization Analysis, Genetic polymorphisms, Atrial fibrillation, Polymorphism, Single Nucleotide, 3. Good health, Adiponectin/genetics, Heart Failure/diagnosis, Myocardial infarction, Risk Factors, Atrial Fibrillation, Atrial Fibrillation/diagnosis, Humans, Adiponectin, Myocardial Infarction/diagnosis, Polymorphism, Aortic Valve Stenosis/epidemiology, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37897683

Reclaiming mendelian randomization from the deluge of papers and misleading findings

Συγγραφείς: Stender, Stefan, Gellert-Kristensen, Helene, Smith, George Davey

Πηγή: Lipids Health Dis
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-4 (2024)
Stender, S, Gellert-Kristensen, H & Smith, G D 2024, ' Reclaiming mendelian randomization from the deluge of papers and misleading findings ', Lipids in Health and Disease, vol. 23, no. 1, 286 . https://doi.org/10.1186/s12944-024-02284-w

Θεματικοί όροι: UK Biobank, RC620-627, Epidemiology, 2SMR, Comment, Mendelian Randomization Analysis/methods, Nonlinear MR, Mendelian Randomization Analysis, Genome-Wide Association Study/methods, Mendelian randomization, Humans, Vitamin D, name=Bristol Population Health Science Institute, Nutritional diseases. Deficiency diseases, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39244551
https://doaj.org/article/9cb1e380191845a392b58f0aeef4866a
https://curis.ku.dk/ws/files/437841701/s12944-024-02284-w.pdf

pyTWMR: transcriptome-wide Mendelian randomization in python

Συγγραφείς: Sergey Oreshkov, Kaido Lepik, Federico Santoni

Πηγή: Bioinformatics
Bioinformatics, vol. 40, no. 8

Θεματικοί όροι: 0301 basic medicine, Mendelian Randomization Analysis/methods, Transcriptome/genetics, Polymorphism, Single Nucleotide, Software, Algorithms, Humans, Applications Note, 0303 health sciences, 03 medical and health sciences, Mendelian Randomization Analysis, Transcriptome

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39128017
https://serval.unil.ch/notice/serval:BIB_975C14D52EEC
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_975C14D52EEC7
https://serval.unil.ch/resource/serval:BIB_975C14D52EEC.P001/REF.pdf

Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure

Συγγραφείς: Mateusz Siedlinski, Lorenzo Carnevale, Xiaoguang Xu, Daniela Carnevale, Evangelos Evangelou, Mark J Caulfield, Pasquale Maffia, Joanna Wardlaw, Nilesh J Samani, Maciej Tomaszewski, Giuseppe Lembo, Michael V Holmes, Tomasz J Guzik

Πηγή: Eur Heart J
Siedlinski, M, Carnevale, L, Xu, X, Carnevale, D, Evangelou, E, Caulfield, M J, Maffia, P, Wardlaw, J, Samani, N J, Tomaszewski, M, Lembo, G, Holmes, M V & Guzik, T J 2023, ' Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure ', European Heart Journal . https://doi.org/10.1093/eurheartj/ehad101
Siedlinski, M, Carnevale, L, Xu, X, Carnevale, D, Evangelou, E, Caulfield, M J, Maffia, P, Wardlaw, J, Samani, N J, Tomaszewski, M, Lembo, G, Holmes, M V & Guzik, T J 2023, 'Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure', European Heart Journal, vol. 44, no. 23, pp. 2114-2125. https://doi.org/10.1093/eurheartj/ehad101
European Heart Journal

Θεματικοί όροι: Genome-wide association study, hypertension, brain, Mendelian Randomization Analysis/methods, Blood Pressure, Cognitive Dysfunction/genetics, Polymorphism, Single Nucleotide, blood pressure, cognitive function, genome-wide association study, mendelian randomisation, Hypertension/complications, Humans, Fast Track Translational Research, Cognitive Dysfunction, Polymorphism, Mendelian randomisation, Brain, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide/genetics, Blood pressure, Cognitive function, Hypertension, Single Nucleotide/genetics, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36972688
https://research.manchester.ac.uk/en/publications/c67a94e1-d53d-43c3-ac99-0efe8d03f6b0
https://doi.org/10.1093/eurheartj/ehad101
https://hdl.handle.net/11588/980703
https://academic.oup.com/eurheartj/article/44/23/2114/7081391?login=true
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehad101/7081391
https://doi.org/10.1093/eurheartj/ehad101
https://hdl.handle.net/20.500.11820/a3245853-db77-4ac4-9cad-1c31f4ffef19
https://www.pure.ed.ac.uk/ws/files/337653504/ehad101.pdf
https://ruj.uj.edu.pl/xmlui/handle/item/310461
https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehad101/7081391
https://hdl.handle.net/11588/980703
https://doi.org/10.1093/eurheartj/ehad101
https://academic.oup.com/eurheartj/article/44/23/2114/7081391?login=true
https://research.manchester.ac.uk/en/publications/c67a94e1-d53d-43c3-ac99-0efe8d03f6b0
http://www.scopus.com/inward/record.url?scp=85163892242&partnerID=8YFLogxK
https://www.mendeley.com/catalogue/3cfd4945-f251-3228-b88d-94efe3391660/
https://doi.org/10.1093/eurheartj/ehad101

Cardiovascular safety of genetically proxied interleukin-5 inhibition: A mendelian randomization study: A mendelian randomization study

Συγγραφείς: Philip Alton, David M. Hughes, Sizheng Steven Zhao

Πηγή: Alton, P, Hughes, D M & Zhao, S S 2023, 'Cardiovascular safety of genetically proxied interleukin-5 inhibition : A mendelian randomization study', Respiratory Investigation, vol. 61, no. 2, pp. 149-152. https://doi.org/10.1016/j.resinv.2022.12.004

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Mendelian Randomization Analysis/methods, Single Nucleotide, Venous Thromboembolism, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, 3. Good health, Stroke, 03 medical and health sciences, Stroke/genetics, Cardiovascular Diseases, Humans, Polymorphism, Interleukin-5, Genome-Wide Association Study

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36682083

Applications of Mendelian randomization in psychiatry: a comprehensive systematic review

Συγγραφείς: Saccaro, Luigi, Gasparini, Simone, Rutigliano, Grazia

Πηγή: Psychiatr Genet

Θεματικοί όροι: Psychiatry, 0301 basic medicine, Depressive Disorder, Major, Reproducibility of Results, Review Article, Mendelian Randomization Analysis, 3. Good health, Causality, 03 medical and health sciences, 0302 clinical medicine, Mendelian Randomization Analysis / methods, 616.89, Humans

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/36354137
http://hdl.handle.net/10044/1/101084
https://archive-ouverte.unige.ch/unige:184652
https://doi.org/10.1097/ypg.0000000000000327

MRSamePopTest: introducing a simple falsification test for the two-sample mendelian randomisation ‘same population’ assumption

Συγγραφείς: Woolf, Benjamin, Mason, Amy, Zagkos, Loukas, Sallis, Hannah, Munafò, Marcus R, Gill, Dipender

Συνεισφορές: DSpace at Cambridge pro (8.1)

Πηγή: BMC Res Notes
BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)

Θεματικοί όροι: Science (General), QH301-705.5, Two-sample Mendelian randomisation, Mendelian Randomization Analysis/methods, Mendelian Randomization Analysis, Population homogeneity, 3. Good health, Causality, Q1-390, Research Note, Phenotype, Genome-Wide Association Study/methods, Medicine, Biology (General), Sensitivity analysis, Genetic Association Studies, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf; application/zip; text/xml

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38233927
https://doaj.org/article/af64a5f89a53494281ed143772a552ee

Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study

Συγγραφείς: Thompson, W D, Reynolds, R M, Beaumont, R N, Warrington, N M, Tyrrell, J, Wood, A R, Evans, D M, McDonald, T J, Hattersley, A H, Freathy, R M, Lawlor, D A, Borges, M C

Πηγή: BMC Pregnancy Childbirth
BMC Pregnancy and Childbirth, Vol 24, Iss 1, Pp 1-11 (2024)
Thompson, WD, Reynolds, RM, Beaumont, RN, Warrington, NM, Tyrrell, J, Wood, AR, Evans, DM, Mcdonald, TJ, Hattersley, AH, Freathy, RM, Lawlor, DA & Borges, MC 2024, ' Maternal plasma cortisol’s effect on offspring birth weight: a Mendelian Randomisation study ', BMC pregnancy and childbirth, vol. 24, no. 1 . https://doi.org/10.1186/s12884-024-06250-3
BMC Pregnancy and Childbirth

Θεματικοί όροι: 0301 basic medicine, UK Biobank, Genotype, Hydrocortisone, Birth Weight/genetics, Mendelian Randomization Analysis/methods, Polymorphism, Single Nucleotide, Cortisol, 03 medical and health sciences, 0302 clinical medicine, Birth weight, Mendelian Randomization, Pregnancy, Humans, Birth Weight, Polymorphism, Efsoch, Research, Infant, Newborn, Infant, Single Nucleotide, Gynecology and obstetrics, Mendelian Randomization Analysis, Newborn, 3. Good health, Causality, RG1-991, Female, name=Bristol Population Health Science Institute, EFSOCH, Genome-Wide Association Study

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Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38225564
https://doaj.org/article/184b224809554cf29e490e6fb1d795b3
https://www.pure.ed.ac.uk/ws/files/413971339/Effect_of_maternal_pregnancy_cortisol_on_offspring_birth_weight_BMC_accepted.docx
https://hdl.handle.net/20.500.11820/79342381-6c79-4be6-99fd-382b951cc939
https://hdl.handle.net/11250/3189160

Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis: Results from pooled cohort studies and Mendelian randomization analysis

Συγγραφείς: Xuan Zhou, Lijuan Wang, Jiarui Xiao, Jing Sun, Lili Yu, Han Zhang, Xiangrui Meng, Shuai Yuan, Maria Timofeeva, Philip J. Law, Richard S. Houlston, Kefeng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li

Συνεισφορές: Law, Philip, Houlston, Richard

Πηγή: Int J Cancer
Zhou, X, Wang, L, Xiao, J, Sun, J, Yu, L, Zhang, H, Meng, X, Yuan, S, Timofeeva, M, Law, P J, Houlston, R S, Ding, K, Dunlop, M G, Theodoratou, E & Li, X 2022, ' Alcohol consumption, DNA methylation and colorectal cancer risk : Results from pooled cohort studies and Mendelian randomization analysis ', International Journal of Cancer, vol. 151, no. 1, pp. 83-94 . https://doi.org/10.1002/ijc.33945

Θεματικοί όροι: 0301 basic medicine, Alcohol Drinking, colorectal cancer, Mendelian Randomization Analysis/methods, Polymorphism, Single Nucleotide, Cancer Genetics and Epigenetics, Alcohol Drinking/epidemiology, Cohort Studies, 03 medical and health sciences, Neoplasm Proteins/genetics, Mendelian randomization, Humans, Polymorphism, Colorectal Neoplasms/epidemiology, 0303 health sciences, DNA methylation, alcohol, Single Nucleotide, DNA Methylation, Mendelian Randomization Analysis, Neoplasm Proteins, 3. Good health, Colorectal Neoplasms, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf; Print-Electronic

Σύνδεσμος πρόσβασης: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.33945
https://pubmed.ncbi.nlm.nih.gov/35102554
https://hdl.handle.net/20.500.11820/df01f2d1-dcc2-408e-9fa9-6bb5b0d8f4a2
https://www.pure.ed.ac.uk/ws/files/252720936/Alcohol_consumption_DNA_methylation_and_colorectal_cancer_risk_Results_from_pooled_cohort_studies_and_Mendelian_randomization_analysis.pdf

PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational attainment.

Συγγραφείς: Darrous, L., Hemani, G., Davey Smith, G., Kutalik, Z.

Πηγή: Nature communications, vol. 15, no. 1, pp. 1420

Θεματικοί όροι: Humans, Child, Genome-Wide Association Study/methods, Mendelian Randomization Analysis/methods, Obesity/epidemiology, Obesity/genetics, Risk Factors, Educational Status, Polymorphism, Single Nucleotide

Περιγραφή αρχείου: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/38360877; info:eu-repo/semantics/altIdentifier/eissn/2041-1723; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_606B3CD782342; https://serval.unil.ch/notice/serval:BIB_606B3CD78234; https://serval.unil.ch/resource/serval:BIB_606B3CD78234.P001/REF.pdf

Διαθεσιμότητα: https://serval.unil.ch/notice/serval:BIB_606B3CD78234
https://doi.org/10.1038/s41467-024-45655-8
https://serval.unil.ch/resource/serval:BIB_606B3CD78234.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_606B3CD782342

Managing the exponential growth of mendelian randomization studies

Συγγραφείς: Munafo, Marcus R, Brown, Jamie, Hefler, Marita, Davey Smith, George

Πηγή: Munafo, M R, Brown, J, Hefler, M & Davey Smith, G 2024, 'Managing the exponential growth of mendelian randomization studies', Tobacco Control, vol. 33, no. 5, pp. 559-560. https://doi.org/10.1136/tc-2024-058987

Θεματικοί όροι: /dk/atira/pure/core/keywords/targ, name=TARG, Humans, Mendelian Randomization Analysis/methods, Research Design

Διαθεσιμότητα: https://hdl.handle.net/1983/42e5f50b-23f1-49e5-9dec-5ad3d3d096b0
https://research-information.bris.ac.uk/en/publications/42e5f50b-23f1-49e5-9dec-5ad3d3d096b0
https://doi.org/10.1136/tc-2024-058987

Managing the Exponential Growth of Mendelian Randomization Studies

Συγγραφείς: Munafò, Marcus, Brown, Jamie, Hefler, Marita, Davey Smith, George

Πηγή: Munafò, M, Brown, J, Hefler, M & Davey Smith, G 2024, 'Managing the Exponential Growth of Mendelian Randomization Studies', Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, vol. 26, no. 10, pp. 1273-1275. https://doi.org/10.1093/ntr/ntae165

Θεματικοί όροι: /dk/atira/pure/core/keywords/targ, name=TARG, Mendelian Randomization Analysis/methods

Διαθεσιμότητα: https://hdl.handle.net/1983/525780f6-08d2-4b90-98dc-00afcae387a4
https://research-information.bris.ac.uk/en/publications/525780f6-08d2-4b90-98dc-00afcae387a4
https://doi.org/10.1093/ntr/ntae165

Bias correction for inverse variance weighting Mendelian randomization

Συγγραφείς: Ninon Mounier, Z. Kutalik

Πηγή: Genetic epidemiology, vol. 47, no. 4, pp. 314-331

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Phenotype, Bias, Humans, Genome-Wide Association Study, Mendelian Randomization Analysis/methods, Polymorphism, Single Nucleotide, Mendelian randomization, sample overlap, weak instrument bias, winner's curse, Mendelian Randomization Analysis

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.biorxiv.org/content/biorxiv/early/2021/03/28/2021.03.26.437168.full.pdf
https://pubmed.ncbi.nlm.nih.gov/37036286
https://europepmc.org/article/PPR/PPR304210
https://biorxiv.org/content/10.1101/2021.03.26.437168v1.full.pdf
https://www.biorxiv.org/content/10.1101/2021.03.26.437168v1
https://serval.unil.ch/resource/serval:BIB_F65931571130.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_F65931571130
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F659315711301