Serum Cytokine Profiles of Melanoma Patients and Their Association with Tumor Progression and Metastasis

Συγγραφείς: Xu Wang, Yoel Genaro Montoyo-Pujol, Sandra Bermudez, Gonzalo Corpas, Aurelio Martin, Francisco Almazan, Teresa Cabrera, Miguel Angel López-Nevot

Συνεισφορές: [Wang,X, Montoyo-Pujol,YG, Bermudez,S, Corpas,G, López-Nevot,MA] Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de Las Nieves, Granada, Spain. [Wang,X] Programa de Doctorado en Biomedicina, Universidad de Granada, Granada, Spain. [Martin,A] Servicio de Anatomía Patológica, Hospital Universitario Virgen de Las Nieves, Granada, Spain. [Almazan,F] Servicio de Dermatología, Hospital Universitario Clínico San Cecilio (PTS), Granada, Spain. [Cabrera,T, López-Nevot,MA] Departamento Bioquímica, Biología Molecular e Inmunología III, Universidad de Granada, Granada, Spain. [López-Nevot,MA] Instituto de Investigación Biosanitaria I Ibs. GRANADA, Granada, Spain., This work was supported by Instituto de Salud Carlos II (FISS PI 13/02119).

Πηγή: J Oncol
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
instname
Digibug. Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug: Repositorio Institucional de la Universidad de Granada
Journal of Oncology
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)

Θεματικοί όροι: Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Epidermal Growth Factor, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Cytokinesis, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Nerve Growth Factors::Brain-Derived Neurotrophic Factor, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins::raf Kinases::Proto-Oncogene Proteins B-raf, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, 3. Good health, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Angiogenic Proteins::Vascular Endothelial Growth Factors::Vascular Endothelial Growth Factor A, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunoassay, 03 medical and health sciences, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-7, 0302 clinical medicine, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Control Groups, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Chemokines, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukin 1 Receptor Antagonist Protein, Research Article

Περιγραφή αρχείου: application/pdf; text/xhtml

Σύνδεσμος πρόσβασης: https://downloads.hindawi.com/journals/jo/2021/6610769.pdf
https://pubmed.ncbi.nlm.nih.gov/33574842
https://hdl.handle.net/10668/26137
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861916/
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8813
http://hdl.handle.net/10668/3987
http://downloads.hindawi.com/journals/jo/2021/6610769.pdf
https://www.ncbi.nlm.nih.gov/pubmed/33574842
https://downloads.hindawi.com/journals/jo/2021/6610769.pdf
https://pubmed.ncbi.nlm.nih.gov/33574842/
https://www.hindawi.com/journals/jo/2021/6610769/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861916
http://hdl.handle.net/10481/67057
https://hdl.handle.net/10668/3987

Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells

Συγγραφείς: Amancio Carnero, Daniel Otero-Albiol, Ana M. Rojas, Sandra Muñoz-Galván, Eva M. Verdugo-Sivianes

Συνεισφορές: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Centro de Investigación Biomédica en Red Cáncer (España), Junta de Andalucía, Fundación Científica Asociación Española Contra el Cáncer, Fundación Eugenio Rodríguez Pascual, [Verdugo-Sivianes,EM, Muñoz-Galván,S, Otero-Albiol,D, Carnero,AS] Instituto de Biomedicina de Sevilla, IBIS, Hospital Universitario Virgen del Rocio, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Spain. [Verdugo-Sivianes,EM, Carnero,AS] CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. [Rojas,AM] Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide, Sevilla, Spain., This work was supported by grants from the Ministerio de Ciencia, Innovación y Universidades (MCIU) Plan Estatal de I+D+I 2018, a la Agencia Estatal de Investigación (AEI) y al Fondo Europeo de Desarrollo Regional (MCIU/AEI/FEDER, UE): RTI2018-097455-B-I00 and RTI2018-096735-B-I00grant from AEI-MICIU/FEDER (RED2018-102723-T), from CIBER de Cáncer (CB16/12/00275), co-funded by FEDER from Regional Development European Funds (European Union), from Consejeria de Salud (PI-0397-2017) and Consejeria of Economía, Conocimiento, Empresas y Universidad of the Junta de Andalucia (P18-RT-2501). Special thanks are also due to the Fundacion AECC and Fundacion Eugenio Rodriguez Pascual for supporting this work.

Πηγή: Theranostics
Digital.CSIC. Repositorio Institucional del CSIC
instname
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía

Θεματικοί όροι: 0301 basic medicine, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Holoenzymes, Carcinogenesis, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic, Retinoblastoma Protein, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Mice, pRB, Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line, Protein Phosphatase 1, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Cycle Checkpoints::G1 Phase Cell Cycle Checkpoints, Phosphorylation, Cell Line, Transformed, Microfilament Proteins, Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Tumor Suppressor Proteins::Retinoblastoma Protein, PP1, Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins, 3. Good health, Gene Expression Regulation, Neoplastic, Medical Subject Headings::Organisms::Eukaryota::Animals, SPINOPHILIN, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylation, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins, Neoplastic Stem Cells, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction, Female, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Drug Evaluation, Preclinical::Drug Screening Assays, Antitumor::Xenograft Model Antitumor Assays, Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells, Research Paper, Signal Transduction, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Stem cell phenotype, Mice, Nude, Breast Neoplasms, Nerve Tissue Proteins, Resting Phase, Cell Cycle, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Nude, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Phosphoprotein Phosphatases::Protein Phosphatase 1, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Tumor Suppressor Proteins::Tumor Suppressor Protein p53, Cancer stem cell, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Eye Neoplasms::Retinal Neoplasms, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice, Medical Subject Headings::Check Tags::Female, G1 Phase Cell Cycle Checkpoints, Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor, Tumorigenesis, Mutation, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle, Pocket proteins, Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Transformed

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/33537097
http://hdl.handle.net/10261/237392
http://hdl.handle.net/10668/4366
https://www.ncbi.nlm.nih.gov/pubmed/33537097
https://pubmed.ncbi.nlm.nih.gov/33537097/
http://digital.csic.es/bitstream/10261/237385/4/SPINOPHILIN.pdf
https://www.thno.org/v11p3452.htm
https://europepmc.org/article/MED/33537097
https://digital.csic.es/handle/10261/237385

Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data

Συγγραφείς: Rian, K, Hidalgo, MR, Çubuk, C, Falco, MM, Loucera, C, Esteban-Medina, M, Alamo-Alvarez, I, Peña-Chilet, M, Dopazo, J

Συνεισφορές: [Rian,K, Çubuk,C, Falco,MM, Loucera,C, Esteban-Medina,M, Alamo-Alvarez,I, Peña-Chilet,M, Dopazo,J] Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), Hospital Virgen del Rocío, Sevilla, Spain. [Rian,K] Laboratory of Innovative Technologies (LTI), National School of Applied Sciences in Tangier, UAE, Morocco. [Hidalgo,MR] Bioinformatics and Biostatistics Unit, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain. [Falco,MM, Dopazo,J] Bioinformatics in RareDiseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Sevilla, Spain. [Loucera,C, Dopazo,J] Computational Systems Medicine. Institute of Biomedicine of Seville (IBiS), Sevilla, Spain. [Dopazo,J] Functional Genomics Node (INB-ELIXIR-es), Sevilla, Spain., This work is supported by grants SAF2017-88908-R from the Spanish Ministry of Economy and Competitiveness and PT17/0009/0006 and PI20/01305 from the ISCIII, both co-funded with European Regional Development Funds (ERDF) as well as H2020 Programme of the European Union grants Marie Curie Inno vative Training Network ‘‘Machine Learning Frontiers in Precision Medicine' (MLFPM) (GA 813533) and ‘‘ELIXIR-EXCELERATE fast track ELIXIR implementation and drive early user exploitation across the life sciences' (GA 676559) to JD. Funding for open access charge: from the Spanish Ministry of Economy and Competitive ness / SAF2017-88908-R, Ministerio de Economía y Competitividad (España), European Commission

Πηγή: Comput Struct Biotechnol J
Computational and Structural Biotechnology Journal
r-FISABIO. Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Universitat Rovira i virgili (URV)
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
instname
Centro de Investigación Principe Felipe (CIPF)
Digital.CSIC. Repositorio Institucional del CSIC
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2968-2978 (2021)

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction, Mathematical modelling, Signaling pathway, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic::Transcriptome, Method Article, 3. Good health, Causality, 03 medical and health sciences, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Transcriptomic, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, TP248.13-248.65, Biotechnology, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics

Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/34136096
https://fisabio.portalinvestigacion.com/publicaciones/13040
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3803
http://hdl.handle.net/10668/3908
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=13040
https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3803
http://hdl.handle.net/10261/265871
https://doaj.org/article/dd3db296c08548de912f2d64bded6ef4
https://pubmed.ncbi.nlm.nih.gov/34136096/
https://researchportal.helsinki.fi/en/publications/genome-scale-mechanistic-modeling-of-signaling-pathways-made-easy
http://www.ncbi.nlm.nih.gov/pubmed/34136096
https://www.sciencedirect.com/science/article/pii/S2001037021002038
https://www.clinbioinfosspa.es/content/genome-scale-mechanistic-modeling-signaling-pathways-made-easy-bioconductorcytoscapeweb
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170118
https://hdl.handle.net/10668/3908

A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors

Συγγραφείς: Jiménez-Sánchez, Juan, Martínez-Rubio, Álvaro, Popov, Anton, Pérez-Beteta, Julián, Azimzade, Youness, Molina-García, David, Belmonte-Beitia, Juan, Calvo, Gabriel F., Pérez-García, Víctor M.

Συνεισφορές: Jiménez-Sánchez,J, Martínez-Rubio,Á, Popov,A, Pérez-Beteta,J, Molina-García,D, Belmonte-Beitia,J, Calvo,GF, Pérez-García,VM Department of Mathematics, Mathematical Oncology Laboratory (MOLAB), Universidad de Castilla-La Mancha, Ciudad Real, Spain. Martínez-Rubio,Á Department of Mathematics, Universidad de Cádiz, Cádiz, Spain. Martínez-Rubio,Á Biomedical Research and Innovation Institute of Cádiz (INiBICA), Cádiz, Spain. Azimzade,Y Department of Physics, University of Tehran, Tehran, Iran., This research has been supported by grants awarded to VMPG by James S. Mc. Donnell Foundation, United States of America, 21st Century Science Initiative in Mathematical and Complex Systems Approaches for Brain Cancer (collaborative award 220020560) and Junta de Comunidades de Castilla-La Mancha, Spain (grant number SBPLY/17/180501/000154). VMPG and GFC thank the funding from Ministerio de Ciencia e Innovación, Spain (grant number PID2019-110895RB-I00). This research has also been supported by a grant awarded to GFC and JBB by the Junta de Comunidades de Castilla-La Mancha,Spain (grant number SBPLY/19/180501/000211). AMR received support from Asociación Pablo Ugarte http://www.asociacionpablougarte.es). JJS received support from Universidad de Castilla-La Mancha (grant number 2020-PREDUCLM-15634)

Θεματικοί όροι: Genetic heterogeneity, Neoplasms, Brain neoplasms, Computational biology, Computer simulation, Cell division, Heterogeneidad genética, Neoplasias, Neoplasias encefálicas, Biología computacional, Simulación por ordenador, División celular, Medical Subject Headings::Phenomena and Processes::Mathematical Concepts::Algorithms, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms::Brain Neoplasms, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Movement, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology, Medical Subject Headings::Information Science::Information Science::Computing Methodologies::Computer Simulation, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Diseases::Neoplasms, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Stochastic Processes

Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Relation: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008266; Jiménez-Sánchez J, Martínez-Rubio Á, Popov A, Pérez-Beteta J, Azimzade Y, Molina-García D, et al. A mesoscopic simulator to uncover heterogeneity and evolutionary dynamics in tumors. PLOS Comput Biol. 2021 Feb 10;17(2):e1008266; http://hdl.handle.net/10668/4454; PMC7901744

Διαθεσιμότητα: http://hdl.handle.net/10668/4454
https://doi.org/10.1371/journal.pcbi.1008266

Layer-Specific Global Longitudinal Strain Predicts Arrhythmic Risk in Arrhythmogenic Cardiomyopathy

Συγγραφείς: Segura-Rodríguez, Diego, Bermúdez-Jiménez, Francisco José, González-Camacho, Lorena, Moreno Escobar, Eduardo, García-Orta, Rocío, Alcalá-López, Juan Emilio, Bautista Pavés, Alicia, Oyonarte-Ramírez, José Manuel, López-Fernández, Silvia, Álvarez, Miguel, Tercedor, Luis, Jiménez-Jáimez, Juan

Συνεισφορές: Segura-Rodríguez,D Cardiology Department, Hospital Universitario San Cecilio, Granada, Spain. Segura-Rodríguez,D, Bermúdez-Jiménez,FJ, Moreno Escobar,E, García-Orta,R, Alcalá-López,JE, Bautista Pavés,A, Oyonarte-Ramírez,JM, López-Fernández,S, Álvarez,M, Tercedor,L, Jiménez-Jáimez,J Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. Bermúdez-Jiménez,FJ, González-Camacho,L, Jiménez-Jáimez,J Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain. Bermúdez-Jiménez,FJ Centro Nacional de Investigaciones Cardiovasculares, CNIC, Instituto de Salud Carlos III, Madrid, Spain.

Θεματικοί όροι: Sudden cardiac death (SCD), Late gadolinium enhanced, Non-sustained ventricular tachycardia, Arrhythmogenic cardiomyopathy (ACM), Global longitudinal strain, Muerte súbita cardíaca, Cardiopatías, Taquicardia ventricular, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Cardiovascular::Heart Function Tests::Cardiac Output::Stroke Volume, Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Rare Earth::Lanthanoid Series Elements::Gadolinium, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Diagnostic Uses of Chemicals::Contrast Media, Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac::Tachycardia::Tachycardia, Ventricular, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Cardiac Imaging Techniques::Echocardiography, Cardiac, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Spectrum Analysis::Magnetic Resonance Spectroscopy, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation

Περιγραφή αρχείου: application/pdf

Relation: https://www.frontiersin.org/articles/10.3389/fcvm.2021.748003/full; Segura-Rodríguez D, Bermúdez-Jiménez FJ, González-Camacho L, Moreno Escobar E, García-Orta R, Alcalá-López JE, et al. Layer-Specific Global Longitudinal Strain Predicts Arrhythmic Risk in Arrhythmogenic Cardiomyopathy. Front Cardiovasc Med. 2021 Nov 15;8:748003.; http://hdl.handle.net/10668/3488; PMC8634435

Διαθεσιμότητα: http://hdl.handle.net/10668/3488
https://doi.org/10.3389/fcvm.2021.748003

Combined Genome, Transcriptome and Metabolome Analysis in the Diagnosis of Childhood Cerebellar Ataxia

Συγγραφείς: Ching-López, Ana, Martinez-Gonzalez, Luis Javier, Arrabal, Luisa, Sáiz, Jorge, Gavilán, Ángela, Barbas, Coral, Lorente, Jose Antonio, Roldán, Susana, Sánchez, Maria José, Gutierrez-Ríos, Purificacion

Συνεισφορές: Ching-López,A, Sánchez,MJ CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. Ching-López,A, Sánchez,MJ Andalusian School of Public Health (EASP), Granada, Spain. Martinez-Gonzalez,LJ, Lorente,JA GENYO, Centre for Genomics and Oncological Research, Pfizer, University of Granada, Andalusian Regional Government, PTS Granada, Granada, Spain. Arrabal,L, Roldán,S Pediatric Neurology Department, Hospital Virgen de las Nieves, Granada, Spain. Sáiz,J, Barbas,C Centre for Metabolomics and Bioanalysis (CEMBIO), Chemistry and Biochemistry Department, Pharmacy Faculty, Universidad San Pablo-CEU, Madrid, Spain. Gavilán,Á Institute of Biomedicine of Seville (IBIS), Seville, Spain. Institute of Biomedicine of Seville (IBIS), Seville, Spain. Lorente,JA Laboratory of Genetic Identification, Legal Medicine and Toxicology Department, Faculty of Medicine-PTS, University of Granada, Granada, Spain. Sánchez,MJ, Gutierrez-Ríos,P Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain., This research was funded by Fundación Mutua Madrileña, Spain (XIII Call on Research Grants 2016, reference number AP163052016).

Θεματικοί όροι: Cerebellar ataxia, Diagnosis, Genomics, Transcriptomics, Metabolomics, Hypomyelination, Leukodystrophy, POLR1C, Ataxia cerebelosa, Diagnóstico, Genómica, Metabolómica, Leucoencefalopatías, ARN polimerasa I, Medical Subject Headings::Persons::Persons::Age Groups::Adolescent, Medical Subject Headings::Persons::Persons::Age Groups::Adult, Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebellar Diseases::Cerebellar Ataxia, Medical Subject Headings::Persons::Persons::Age Groups::Child, Medical Subject Headings::Persons::Persons::Age Groups::Child::Child, Preschool, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Nucleotidyltransferases::RNA Nucleotidyltransferases::DNA-Directed RNA Polymerases, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome, Medical Subject Headings::Check Tags::Male, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolome, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Pedigree, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription

Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Relation: https://www.mdpi.com/1422-0067/22/6/2990/htm; Ching-López A, Martinez-Gonzalez LJ, Arrabal L, Sáiz J, Gavilán Á, Barbas C, et al. Combined Genome, Transcriptome and Metabolome Analysis in the Diagnosis of Childhood Cerebellar Ataxia. Int J Mol Sci. 2021 Mar 15;22(6):2990; http://hdl.handle.net/10668/4074; PMC8002209

Διαθεσιμότητα: http://hdl.handle.net/10668/4074
https://doi.org/10.3390/ijms22062990

A versatile workflow to integrate RNA-seq genomic and transcriptomic data into mechanistic models of signaling pathways

Συγγραφείς: Garrido-Rodriguez, Martín, Lopez-Lopez, Daniel, Ortuno, Francisco M., Peña-Chilet, María, Muñoz, Eduardo, Calzado, Marco A., Dopazo, Joaquin

Συνεισφορές: Garrido-Rodriguez,M, Lopez-Lopez,D, Ortuno,FM, Peña-Chilet,M, Dopazo,J Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), Hospital Virgen del Rocío, Sevilla, Spain. Garrido-Rodriguez,M, Calzado,MA Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain. Garrido-Rodriguez,M, Muñoz,E, Calzado,MA Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. Garrido-Rodriguez,M, Calzado.MA Hospital Universitario Reina Sofía, Córdoba, Spain. Lopez-Lopez.D: Ortuno,FM, Dopazo,J Computational Systems Medicine, Institute of Biomedicine of Seville (IBIS), Sevilla, Spain. Peña-Chilet,M, Dopazo,J Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocío, Sevilla, Spain. Dopazo,J FPS/ELIXIR-es, Hospital Virgen del Rocío, Sevilla, Spain, JD has received these grants: SAF2017- 88908-R from the Ministerio de Economı´a y Competitividad and PT17/0009/0006 from the Instituto de Salud Carlos III, as well as an FP7 People Marie-Curie Actions 813533 and and Horizon 2020 Framework Programme 676559. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Θεματικοί όροι: Transcriptome, RNA massive sequencing, RNA-seq, Workflow, Signaling pathways, Transcriptoma, Flujo de trabajo, Secuenciación de escopeta completa del transcriptoma, Medical Subject Headings::Phenomena and Processes::Mathematical Concepts::Algorithms, Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology, Medical Subject Headings::Information Science::Information Science::Information Storage and Retrieval::Databases as Topic::Databases, Factual, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Information Science::Information Science::Computing Methodologies::Software, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Transcription, Genetic::Transcriptome, Medical Subject Headings::Information Science::Information Science::Systems Analysis::Workflow, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Signal Transduction

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Relation: https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008748; Garrido-Rodriguez M, Lopez-Lopez D, Ortuno FM, Peña-Chilet M, Muñoz E, Calzado MA, et al. A versatile workflow to integrate RNA-seq genomic and transcriptomic data into mechanistic models of signaling pathways. PLoS Comput Biol. 2021 Feb 11;17(2):e1008748; http://hdl.handle.net/10668/4220; PMC7904194

Διαθεσιμότητα: http://hdl.handle.net/10668/4220
https://doi.org/10.1371/journal.pcbi.1008748

The Combination of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Liquid Biopsy Biomarkers Improves Prognosis Prediction in Metastatic Pancreatic Cancer

Συγγραφείς: Toledano-Fonseca, Marta, Cano, M Teresa, Inga, Elizabeth, Gómez-España, Auxiliadora, Guil-Luna, Silvia, García-Ortiz, María Victoria, Mena-Osuna, Rafael, De la Haba-Rodriguez, Juan R., Rodríguez-Ariza, Antonio, Aranda, Enrique

Συνεισφορές: Toledano-Fonseca,M, Guil-Luna,S, García-Ortiz,MV, Mena-Osuna,R, De la Haba-Rodriguez,JR, Rodríguez-Ariza,A, Aranda,E Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain. Toledano-Fonseca,M, Aranda,E Cancer Network Biomedical Research Centre (CIBERONC), 28029 Madrid, Spain. Toledano-Fonseca,M, Cano,MT, Inga,E, Gómez-España,A, Aranda,E Andalusia-Roche Network Mixed Alliance in Precision Medical Oncology, Sevilla, Spain. Cano,MT, Aranda,E Medical Oncology Department, Reina Sofía University Hospital, Córdoba, Spain. De la Haba-Rodriguez,JR, Aranda,E Department of Medicine, Faculty of Medicine, University of Córdoba, Córdoba, Spain., This study was funded by Centro de Investigación Biomédica en Red de Cáncer (CB16/12/00349) and by the Alianza Mixta en Red Andalucía-Roche en Oncología Médica de Precisión. A.R-A. has a researcher contract funded by the program “Nicolás Monardes” from Junta de Andalucía.

Θεματικοί όροι: NLR, PLR, Circulating tumor DNA, Pancreatic ductal adenocarcinoma, RAS mutation, Neutrophil elastase, Neutrofilos, Linfocitos, Plaquetas, ADN tumoral circulante, Carcinoma ductal pancreático, Proteínas ras, Elastasa de leucocito, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Neoplasm::Antigens, Tumor-Associated, Carbohydrate::CA-19-9 Antigen, Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Neutrophil Activation, Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment

Περιγραφή αρχείου: application/pdf

Relation: https://www.mdpi.com/2072-6694/13/6/1210/htm; Toledano-Fonseca M, Cano MT, Inga E, Gómez-España A, Guil-Luna S, García-Ortiz MV, et al. The Combination of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with Liquid Biopsy Biomarkers Improves Prognosis Prediction in Metastatic Pancreatic Cancer. Cancers. 2021 Mar 10;13(6):1210; http://hdl.handle.net/10668/4427; PMC7998484

Διαθεσιμότητα: http://hdl.handle.net/10668/4427
https://doi.org/10.3390/cancers13061210

nab-Paclitaxel Plus Durvalumab in Patients With Previously Treated Advanced Stage Non-small Cell Lung Cancer (ABOUND.2L+)

Συγγραφείς: Morgensztern, Daniel, Dols, Manuel Cobo, Ponce Aix, Santiago, Postmus, Pieter E., Bennouna, Jaafar, Fischer, Jürgen R., Juan-Vidal, Oscar, Stewart, David J., Ardizzoni, Andrea, Bhore, Rafia, Wolfsteiner, Marianne, Reck, Martin, Talbot, Denis, Govindan, Ramaswamy, Ong, Teng Jin

Συνεισφορές: ABOUND.2L+, Morgensztern,D, Govindan,R Washington University School of Medicine, St Louis, MO, United States. Cobo Dols,Manuel Hospital Universitario Málaga Regional, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. Ponce Aix,S Unidad de Investigación Clínica de Cáncer Pulmón H12O-CNIO, Madrid, Spain. Postmus,PE Clatterbridge Cancer Center, Liverpool, United Kingdom. Bennouna,J Centre René Gauducheau Centre de Lutte Contre Le Cancer Nantes Atlantique, Nantes, France. Fischer,JR Lungenklinik Löwenstein gGmbH, Löwenstein, Germany. Juan-Vidal,O Universitari i Politécnic La Fe, Valencia, Spain. Stewart,DJ Ottawa Hospital, Ottawa, ON, Canada. Ardizzoni,A Azienda Ospedaliero Universitaria Di Bologna—Policlinico S. Orsola-Malpighi, Bologna, Italy. Bhore,R Bristol Myers Squibb, Princeton, NJ, United States. Wolfsteiner,M Pharmaceutical Research Associates Inc. (PRA) Health Sciences, Lenexa, KS, United States. Reck,M LungenClinic, Grosshansdorf, Germany. Talbot,D Churchill Hospital, Oxford, United Kingdom, This work was supported by Bristol Myers Squibb Company, Princeton, New Jersey. The sponsor was involved in the design of the study as well as in the collection, analysis, and interpretation of the data. The sponsor agreed to the decision to submit the article for publication.

Θεματικοί όροι: Advanced stage non-small cell lung cancer, Durvalumab, Immune checkpoint blocker plus chemotherapy, nab-paclitaxel, Second-line therapy, Carcinoma de pulmón de células no pequeñas, Puntos de control inmunológico, Quimioterapia, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell Lung, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Asthenia, Signs and Symptoms::Signs and Symptoms::Signs and Symptoms, Digestive::Diarrhea, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Receptor Protein-Tyrosine Kinases

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2020.569715/full; Morgensztern D, Dols MC, Ponce Aix S, Postmus PE, Bennouna J, Fischer JR, et al. nab-Paclitaxel Plus Durvalumab in Patients With Previously Treated Advanced Stage Non-small Cell Lung Cancer (ABOUND.2L+). Front Oncol. 2021 Feb 11;10:569715; http://hdl.handle.net/10668/4015; PMC7906015

Διαθεσιμότητα: http://hdl.handle.net/10668/4015
https://doi.org/10.3389/fonc.2020.569715

Improving Familial Hypercholesterolemia Index Case Detection: Sequential Active Screening from Centralized Analytical Data

Συγγραφείς: Sabatel-Pérez, Fernando, Sánchez-Prieto, Joaquín, Becerra-Muñoz, Víctor Manuel, Alonso-Briales, Juan Horacio, Mata, Pedro, Rodríguez-Padial, Luis

Συνεισφορές: Sabatel-Pérez,F, Sánchez-Prieto,J, Rodríguez-Padial,L Department of Cardiology, Complejo Hospitalario Universitario de Toledo, Toledo, Spain. Sabatel-Pérez,F, Becerra-Muñoz,VM, Alonso-Briales,JH Unidad de Gestión Clínica Área del Corazón, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria de Málaga, Universidad de Málaga (UMA), Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Málaga, Spain. Mata,P Fundación Hipercolesterolemia Familiar, Madrid, Spain., This research received funding support for genetic testing from Sanofi-Aventis España SA and Amgen España SA, as well as support for statistical analysis and translation from the Chair of Advanced Therapies in Cardiovascular Pathologies, University of Málaga.

Θεματικοί όροι: Familial hypercholesterolemia, Genetic screening, Atherosclerosis prevention, Early detection, Hiperlipoproteinemia tipo II, Pruebas genéticas, Aterosclerosis, Prevención primaria, Diagnóstico precoz, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals, Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::Hypercholesterolemia, Medical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Metabolism, Inborn Errors::Lipid Metabolism, Inborn Errors::Hyperlipoproteinemia Type II, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Genetic Testing, Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL, Medical Subject Headings::Chemicals and Drugs::Lipids, Medical Subject Headings::Chemicals and Drugs::Lipids::Sterols::Cholesterol

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Relation: https://www.mdpi.com/2077-0383/10/4/749/htm; Sabatel-Pérez F, Sánchez-Prieto J, Becerra-Muñoz VM, Alonso-Briales JH, Mata P, Rodríguez-Padial L. Improving Familial Hypercholesterolemia Index Case Detection: Sequential Active Screening from Centralized Analytical Data. J Clin Med. 2021 Feb 13;10(4):749; http://hdl.handle.net/10668/4254; PMC7918446

Διαθεσιμότητα: http://hdl.handle.net/10668/4254
https://doi.org/10.3390/jcm10040749

Identification of Exosomal MicroRNA Signature by Liquid Biopsy in Hereditary Hemorrhagic Telangiectasia Patients

Συγγραφείς: Pozo-Agundo, Ana, Villaescusa, Nerea, Martorell-Marugán, Jordi, Soriano, Olga, Leyva, Socorro, Jódar-Reyes, Ana Belén, Botella, Luisa María, Carmona-Sáez, Pedro, Blanco, Francisco Javier

Συνεισφορές: Pozo-Agundo,A, Villaescusa,N, Soriano,O, Blanco,FJ Department of Biochemistry and Molecular Biology (III) and Inmunology, School of Medicine, University of Granada, Granada, Spain. Pozo-Agundo,A, Blanco,FJ Centre for Biomedical Research, Biopathology and Regenerative Medicine Institute (IBIMER), University of Granada, Granada, Spain. Martorell-Marugán,J, Carmona-Sáez,P Bioinformatics Unit, Pfizer, Andalusian Government Centre of Genomics and Oncological Research (GENYO), University of Granada, Granada, Spain. Martorell-Marugán,J, Carmona-Sáez,P Department of Statistics and OR, University of Granada, Granada, Spain. Leyva,S San Cecilio Clinic Universitary Hospital, Granada, Spain. Jódar-Reyes,AB Biocolloid and Fluid Physics Group, Excellence Research Unit Modeling Nature (MNat), Department of Applied Physics, School of Sciences, University of Granada, Granada, Spain. Botella,LM Department of Molecular Biomedicine, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain. Botella,LM Centro de Investigación Biomédica en Red, CIBERER, Instituto de Salud Carlos III, Madrid, Spain., This work was funded by the Spanish Program for Young Investigators of the Ministerio de Economía y Competitividad and Fondo Europeo de Desarrollo Regional (grant number SAF2015-74313JIN, MINECO/FEDER, UE) to FJB, and “Programa Operativo FEDER 2014–2020 and Consejería de Economía y Conocimiento de la Junta de Andalucía” (grant number B1-FQM-112-UGR18) to ABJR

Θεματικοί όροι: Hereditary hemorrhagic telangiectasia, Liquid biopsy, Exosomes, MiRNAs, Arteriovenous malformations, Telangiectasia hemorrágica hereditaria, Biopsia líquida, Exosomas, MicroARNs, Malformaciones arteriovenosas, Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, CD, Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arteriovenous Malformations, Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies, Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Transport Vesicles::Exosomes, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation

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Relation: https://www.mdpi.com/1422-0067/22/17/9450/htm; Pozo-Agundo A, Villaescusa N, Martorell-Marugán J, Soriano O, Leyva S, Jódar-Reyes AB, et al. Identification of Exosomal MicroRNA Signature by Liquid Biopsy in Hereditary Hemorrhagic Telangiectasia Patients. Int J Mol Sci. 2021 Aug 31;22(17):9450; http://hdl.handle.net/10668/3979; PMC8431573

Διαθεσιμότητα: http://hdl.handle.net/10668/3979
https://doi.org/10.3390/ijms22179450

Harmful R-loops are prevented via different cell cycle-specific mechanisms

Συγγραφείς: San Martin-Alonso, Marta, Soler-Oliva, María E., García-Rubio, María, García-Muse, Tatiana, Aguilera, Andrés

Συνεισφορές: San Martin-Alonso,M, Soler-Oliva,ME, García-Rubio,M, García-Muse,T, Aguilera,A Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC-UPO, Seville, Spain.

Θεματικοί όροι: Cell Cycle, DNA Damage, DNA Helicases, Genomic Instability, Mutation, Nuclear Proteins, RNA, Fungal, Ciclo Celular, Daño del ADN, ADN Helicasas, Inestabilidad Genómica, Mutación, Proteínas Nucleares, ARN de Hongos, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Acid Anhydride Hydrolases::Adenosine Triphosphatases::DNA Helicases, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genomic Instability, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biological, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins

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Relation: https://www.nature.com/articles/s41467-021-24737-x; San Martin-Alonso M, Soler-Oliva ME, García-Rubio M, García-Muse T, Aguilera A. Harmful R-loops are prevented via different cell cycle-specific mechanisms. Nature Communications. 2021;12(1):4451.; http://hdl.handle.net/10668/3470; PMC8298424

Διαθεσιμότητα: http://hdl.handle.net/10668/3470
https://doi.org/10.1038/s41467-021-24737-x

Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre

Συγγραφείς: Castejón-Vega, Beatriz, Battino, Maurizio, Quiles, José L., Bullon, Beatriz, Cordero, Mario D., Bullón, Pedro

Συνεισφορές: Castejón-Vega,B Research Laboratory, Dental School, University of Sevilla, Sevilla, Spain. Battino,M Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche, Sez. Biochimica, Università Politecnica delle Marche, Ancona, Italy. Battino,M International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China. Quiles,JL Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center (CIBM), University of Granada, Armilla, Spain. Quiles,JL Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Santander, Spain. Bullon,B, Bullón,P Department of Periodontology, Dental School, University of Sevilla, Sevilla, Spain. Cordero,MD Instituto de Investigación e Innovación en Ciencias Biomédicas de Cádiz, INiBICA, Cadiz, Spain. Cordero,MD Cátedra de Reproducción y Genética Humana del Instituto para el Estudio de la Biología de la Reproducción Humana (INEBIR)-Universidad Europea del Atlántico (UNEATLANTICO)-Fundación Universitaria Iberoamericana (FUNIBER), Santander, Spain., This research was funded by by a grant from the Andalusian regional government (Grupo de Investigacion Junta de Andalucia CTS113).

Θεματικοί όροι: Papillon–Lefèvre syndrome, Mitochondria, Coenzyme Q10, Enfermedad de Papillon-Lefevre, Mitocondrias, Ubiquinona, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cathepsins::Cathepsin C, Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Species, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Fibroblasts, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress, Medical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::Periodontitis, Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Topical, Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Oxygen Consumption, Medical Subject Headings::Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Circular::DNA, Mitochondrial

Περιγραφή αρχείου: application/pdf

Relation: https://www.mdpi.com/2076-3921/10/1/95/htm; Castejón-Vega B, Battino M, Quiles JL, Bullon B, Cordero MD, Bullón P. Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre. Antioxidants (Basel). 2021 Jan 12;10(1):95; http://hdl.handle.net/10668/4019; PMC7827181

Διαθεσιμότητα: http://hdl.handle.net/10668/4019
https://doi.org/10.3390/antiox10010095

Generation of the human iPSC line ESi082-A from a patient with macular dystrophy associated to mutations in the CRB1 gene

Συγγραφείς: Cañibano-Hernández, Alberto, Valdes-Sanchez, Lourdes, Garcia-Delgado, Ana B., Ponte-Zúñiga, Beatriz, Diaz-Corrales, Francisco J., de la Cerda, Berta

Συνεισφορές: Cañibano-Hernández,A, Valdes-Sanchez,L, Garcia-Delgado,AB, Diaz-Corrales,FJ, de la Cerda,B Department of Regeneration and Cell Therapy, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Seville, Spain. Ponte-Zúñiga,B University Hospital Virgen Macarena, RETICS Oftared, Carlos III Institute of Health (Spain), Ministry of Health RD16/0008/0010, Seville, Spain., This work was supported by Andalusian Ministry of Health, Equality and Social Policies (PI-0099-2018).

Θεματικοί όροι: Retinal dystrophies, Mutations, Macular dystrophy, Cell line, CRB1 gene, Genotype, Distrofias retinianas, Mutación, Degeneración macular, Línea celular, Genotipo, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, and Proteins::Proteins::Nerve Tissue Proteins, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Pedigree, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Medical Subject Headings::Anatomy::Cells::Stem Cells::Pluripotent Stem Cells::Induced Pluripotent Stem Cells, Medical Subject Headings::Diseases::Eye Diseases::Retinal Diseases::Retinal Degeneration::Macular Degeneration, Medical Subject Headings::Diseases::Eye Diseases::Retinal Diseases::Retinal Degeneration::Retinal Dystrophies, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype, Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line, and Proteins::Proteins::Eye Proteins

Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: https://www.sciencedirect.com/science/article/pii/S1873506121001471; Cañibano-Hernández A, Valdes-Sanchez L, Garcia-Delgado AB, Ponte-Zúñiga B, Diaz-Corrales FJ, de la Cerda B. Generation of the human iPSC line ESi082-A from a patient with macular dystrophy associated to mutations in the CRB1 gene. Stem Cell Res. 2021 May;53:102301.; http://hdl.handle.net/10668/4158

Διαθεσιμότητα: http://hdl.handle.net/10668/4158
https://doi.org/10.1016/j.scr.2021.102301

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases

Συγγραφείς: Mercedes M. Pérez-Jiménez, Irene Suárez-Pereira, Sara Esteban-García, Ana María Brokate-Llanos, Marta Artal-Sanz, Amador Valladares, Angel M. Carrión, José M. Monje-Moreno, Paula Sansigre, Mónica Venegas-Calerón, Alicia Sánchez-García, Javier Vitorica, Manuel Muñoz, José Ríos

Συνεισφορές: Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, [Pérez-Jiménez,MM, Monje-Moreno,JM, Brokate-Llanos,AM, Sansigre,P, Valladares,A, Artal-Sanz,M, Muñoz,MJ] Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JA, Sevilla, Spain. [Venegas-Calerón,M, Sánchez-García,A, Ríos,JJ] Instituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide (UPO), Sevilla, Spain. [Esteban-García,S, Suárez-Pereira,I, Carrión,AM] Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide (UPO), Sevilla, Spain. [Vitorica,J] Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. [Vitorica,J] Instituto de Biomedicina de Sevilla (IBiS)-Hospital Universitario Virgen del Rocío/ CSIC/Universidad de Sevilla, Sevilla, Spain. [Vitorica,J] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Suárez-Pereira,I] Europsychopharmacology and psychobiology research group, Universidad de Cadiz, CIBERSAM, INiBICA, Cadiz, Spain., This work was supported by the Junta de Andalucía Project P07-CVI-02697, 'Fondo Europeo de Desarrollo Regional' (FEDER) and the 'Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía' Project UPO-1266266 and the European Research Council ERC-2011-StG-281691. We also acknowledge the support from the Centro Andaluz de Biología del Desarrollo (CABD)., Junta de Andalucía, European Coal and Steel Community, European Research Council

Πηγή: Nat Commun
idUS. Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
idUS: Depósito de Investigación de la Universidad de Sevilla
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
instname
RIO. Repositorio Institucional Olavide
Universidad Pablo de Olavide (UPO)
Digital.CSIC. Repositorio Institucional del CSIC
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Θεματικοί όροι: 0301 basic medicine, Aging, Medical Subject Headings::Anatomy::Cells::Neurons::Neurons, Afferent::Sensory Receptor Cells, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Sensory Receptor Cells, Science, Longevity, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Sulfatases, Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Longevity, STX64, Medical Subject Headings::Anatomy::Cells::Germ Cells, Neurodegenerative disease, Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Cues, Article, Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Helminths::Nematoda::Secernentea::Rhabditida::Rhabditoidea::Caenorhabditis::Caenorhabditis elegans, Mice, 03 medical and health sciences, Alzheimer Disease, Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Gonads, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epistasis, Genetic, 0303 health sciences, Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids, Proteostasis lost, Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal, Sul2, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice, Epistasis, Genetic, Medical Subject Headings::Anatomy::Urogenital System::Genitalia::Gonads, Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones::Testosterone Congeners::Testosterone, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals, Medical Subject Headings::Organisms::Eukaryota::Animals, Disease Models, Animal, Phenotype, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Steroids, Steryl-Sulfatase, Alzheimer disease, Sulfatases, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Helminth Proteins::Caenorhabditis elegans Proteins, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Sulfatases::Arylsulfatases::Steryl-Sulfatase, Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Fertility

Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41467-020-20269-y.pdf
https://pubmed.ncbi.nlm.nih.gov/33397961
https://hdl.handle.net/11441/104920
https://idus.us.es/handle//11441/104920
http://hdl.handle.net/10668/4311
https://hdl.handle.net/10433/22856
http://hdl.handle.net/10261/229268
https://doaj.org/article/873769f1ad43491084d967f67bef724d
https://www.nature.com/articles/s41467-020-20269-y.pdf
https://europepmc.org/article/PPR/PPR69110
https://digital.csic.es/handle/10261/229268
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7782729/
https://idus.us.es/handle/11441/104920
http://ui.adsabs.harvard.edu/abs/2021NatCo..12...49P/abstract

Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid

Συγγραφείς: Sanchez, Ricardo, Ayala, Rosa, Alonso, Rafael Alberto, Martínez, María Pilar, Ribera, Jordi, García, Olga, Sanchez-Pina, José, Mercadal, Santiago, Montesinos, Pau, Martino, Rodrigo, Barba, Pere, González-Campos, José, Barrios, Manuel, Lavilla, Esperanza, Gil, Cristina, Bernal, Teresa, Escoda, Lourdes, Abella, Eugenia, Amigo, Ma Luz, Moreno, Ma José, Bravo, Pilar, Guàrdia, Ramón, Hernández-Rivas, Jesús-María, García-Guiñón, Antoni, Piernas, Sonia, Ribera, José-María, Martínez-López, Joaquín

Συνεισφορές: Hospital Universitario de Fuenlabrada. Servicio de Hematología, Fundación CRIS contra el Cáncer, Instituto de Salud Carlos III, Red Temática de Investigación Cooperativa en Cáncer (España), [Sanchez,R, Ayala,R, Alonso,RA, Martínez,MP, Sanchez-Pina, Martínez-López,J] Instituto de Investigación Hospital 12 de Octubre (i+12), Servicio de Hematología, Hematología Traslacional, Hospital Universitario 12 de Octubre, Spain. [Ribera,J, García,O, Ribera,JM] Institut de Recerca contra la Leucèmia Josep Carreras, ICO-Hospital Germans Trias i Pujol, Badalona, Spain. [Mercadal,S] ICO-Hospital Duran i Reynals (Bellvitge), Barcelona, Spain. [Montesinos,P] Hospital Universitari i Politècnic La Fe, Valencia, Spain. [Martino,R] Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. [Barba,P] Hospital Universitari Vall d’Hebron, Barcelona, Spain. [González-Campos,J] Hospital Universitario Virgen del Rocío, Sevilla, Spain. [Barrios,M] Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Lavilla,E] Hospital Universitario Lucus Augusti, Lugo, Spain. [Gil,C] Hospital General Universitario de Alicante, Alicante, Spain. [Bernal,T] Hospital Universitario Central de Asturias, Oviedo, Spain. [Escoda,L] Hospital Universitari Joan XXIII, Tarragona, Spain. [Abella,E] Hospital del Mar, Barcelona, Spain. [Amigo,ML] Hospital General Universitario Morales Meseguer, Murcia, Spain. [Moreno,MJ] Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Bravo,P] Hospital de Fuenlabrada, Fuenlabrada, Madrid, Spain. [Guàrdia,R] ICO-Hospital Universitari Dr. Josep Trueta, Girona, Spain. [Hernández-Rivas,JM] Hospital Universitario de Salamanca, Salamanca, Spain. [García-Guiñón,A] Hospital Universitari Arnau de Vilanova, Lleida, Spain. [Piernas,S] Hospital Universitari Parc Taulí, Sabadell, Barcelona, Spain.

Πηγή: Ann Hematol
ANNALS OF HEMATOLOGY
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
Instituto de Investigación Sanitaria La Fe (IIS La Fe)
Annals of Hematology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Institut de Recerca Germans Trias i Pujol (IGTP)

Θεματικοί όροι: Adult, Central Nervous System, Male, Models, Molecular, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteins::Oncogene Proteins::Proto-Oncogene Proteins::Proto-Oncogene Proteins c-bcr, Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Single-Stranded::DNA, Complementary, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Fusion Proteins, bcr-abl, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoid::Precursor Cell Lymphoblastic Leukemia-Lymphoma, Kaplan-Meier Estimate, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow, Secuenciación de Nucleótidos de Alto Rendimiento, Outcome Assessment (Health Care), 03 medical and health sciences, 0302 clinical medicine, Recurrence, Estimación de Kaplan-Meier, Outcome Assessment, Health Care, Humans, Acute lymphoblastic leukemia relapse, Proto-Oncogene Proteins c-abl, Aged, Aged, 80 and over, Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamides::Imatinib Mesylate, Mutación, Sistema nerviós central, Neoplasia, Proteínas Proto-Oncogénicas c-abl, High-Throughput Nucleotide Sequencing, Estructura Terciaria de Proteína, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Clonal Evolution, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::High-Throughput Nucleotide Sequencing, Leucemia-Linfoma Linfoblástico de Células Precursoras, BCR-ABL1, Protein Structure, Tertiary, 3. Good health, Mutation analysis, Leucèmia limfoblàstica, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence, Central nervous system, Mutation, Feasibility Studies, Original Article, Female, Sistema Nervioso Central

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://link.springer.com/content/pdf/10.1007%2Fs00277-017-3002-1.pdf
https://pubmed.ncbi.nlm.nih.gov/28451802
https://fundanet.isabial.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6284
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=14233
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=6827
https://hdl.handle.net/20.500.12530/32015
http://hdl.handle.net/10261/182523
http://hdl.handle.net/10668/2672
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7522
https://europepmc.org/articles/PMC5486784
https://link.springer.com/content/pdf/10.1007%2Fs00277-017-3002-1.pdf
https://pubmed.ncbi.nlm.nih.gov/28451802/
https://www.ncbi.nlm.nih.gov/pubmed/28451802
https://www.repositoriosalud.es/handle/10668/2672
https://link.springer.com/article/10.1007/s00277-017-3002-1
https://hdl.handle.net/10668/2672

Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape

Συγγραφείς: Salguero-Aranda, Carmen, Amaral, Ana Teresa, Olmedo-Pelayo, Joaquín, Diaz-Martin, Juan, de Álava, Enrique

Συνεισφορές: Salguero-Aranda,C, Amaral,AT, Olmedo-Pelayo,J, Diaz-Martin,J, de Álava,E Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital/CSIC/University of Sevilla/CIBERONC, Seville, Spain. Olmedo-Pelayo,J, de Álava,E Department of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, Seville, Spain, This work was supported by grants from the Consejería de Salud (Junta de Andalucía, grants No PI-0036-2017 and PI-0040-2017) awarded to JDM and ATA, respectively, by grants from the Asociación Pablo Ugarte, Fundación María García Estrada and FARO niños con cáncer to JDM and EdA. EdA’s laboratory is supported by the AECC project (GCB13-1578), ISCIIIFEDER (PI14/01466, PI17/00464), CIBERONC (CB16/12/00361) and Fundación CRIS Contra el Cáncer. This work was also supported by a Juan de la Cierva Incorporación fellowship (IJC-2018-036767-I) to ATA, and a pre-doctoral fellowship from the VI Plan Propio from the Universidad de Sevilla to JOP.

Θεματικοί όροι: Sarcoma, Ewing sarcoma, GF, Extracellular vesicles, Circulating tumor DNA/RNA, DNA repair, Breakthrough technologies, Mutations, Sarcoma de Ewing, Fusión génica, Vesículas extracelulares, ADN tumoral circulante, Reparación del ADN, Mutación, Secuenciación de nucleótidos de alto rendimiento, Medical Subject Headings::Organisms::Eukaryota::Animals, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Molecular Targeted Therapy, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Connective Tissue::Neoplasms, Bone Tissue::Osteosarcoma::Sarcoma, Ewing, Connective and Soft Tissue::Sarcoma, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Persons::Persons::Age Groups::Adult::Young Adult, Medical Subject Headings::Persons::Persons::Age Groups::Child

Περιγραφή αρχείου: application/pdf

Relation: https://www.mdpi.com/2073-4409/9/4/804/htm; Salguero-Aranda C, Amaral AT, Olmedo-Pelayo J, Diaz-Martin J, de Álava E. Breakthrough Technologies Reshape the Ewing Sarcoma Molecular Landscape. Cells. 2020 Mar 26;9(4):804; http://hdl.handle.net/10668/3811; PMC7226764

Διαθεσιμότητα: http://hdl.handle.net/10668/3811
https://doi.org/10.3390/cells9040804

Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia

Συγγραφείς: Barad, Maya, Csukasi, Fabiana, Bosakova, Michaela, Martin, Jorge H., Zhang, Wenjuan, Paige Taylor, S., Lachman, Ralph S., Zieba, Jennifer, Bamshad, Michael, Nickerson, Deborah, Chong, Jessica X., Cohn, Daniel H., Krejci, Pavel, Krakow, Deborah, Duran, Ivan

Συνεισφορές: Barad,M, Csukasi,F, Martin,JH, Paige Taylor,S, Zieba,J, Cohn,DH, Krakow,D, Duran,I Department of Orthopaedic Surgery, University of California-Los Angeles, CA, United States. Csukasi,F, Duran,I Laboratory of Bioengineering and Tissue Regeneration-LABRET, Department of Cell Biology, Genetics and Physiology, University of Malaga, IBIMA, Málaga,Spain. Bosakova,M, Krejci,P Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Bosakova,M, Krejci,P International Clinical Research Center, St. Anne’s University Hospital, Brno, Czech Republic. Zhang,W, Cohn,DH Department of Molecular, Cell and Developmental Biology, University of California-Los Angeles, CA, United States. Lachman,RS, Krakow,D International Skeletal Dysplasia Registry, University of California, Los Angeles, United States. Bamshad,M, Nickerson,D, Chong,JX University of Washington Center for Mendelian Genomics, University of Washington, Seattle, WA, United States. Cohn,DH, Krakow,D Orthopaedic Institute for Children, University of California Los Angeles, Los Angeles, CA, United States. Krakow,D Department of Human Genetics, University of California-Los Angeles, CA, United States. Durán,I Networking Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Andalusian Centre for Nanomedicine and Biotechnology-BIONAND, Málaga, Spain., D.K. and D.H.C are supported by the NIH grants R01 AR066124, R01 DE019567, R01 HD070394. Sequencing was provided by the University of Washington Center for Mendelian Genomics (UWCMG) which is funded by the National Human Genome Research Institute (NHGRI) and the National Heart, Lung and Blood Institute (NHLBI) Award 1U54HG006493. P.K was supported by the Ministry of Education, Youth and Sports of the Czech Republic (Grant INTER-ACTION LTAUSA19030), the Agency for Healthcare Research of the Czech Republic (Grant NV18-08-00567), and the Czech Science Foundation (Grant GA19-20123S).

Θεματικοί όροι: Laminin α5, LAMA5, Skeletal dysplasia, Bent bone, β1 integrin, Fibrous dysplasia of bone, Integrina beta1, Displasia fibrosa ósea, Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Developmental, Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Adhesion, Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Chondrocytes, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA::DNA Mutational Analysis, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::Focal Adhesion Protein-Tyrosine Kinases::Focal Adhesion Kinase 2, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Laminin, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype, Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction::Wnt Signaling Pathway, Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Tyrosine Kinases::src-Family Kinases, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction

Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.presentationml.presentation; application/vnd.openxmlformats-officedocument.wordprocessingml.document

Relation: https://www.sciencedirect.com/science/article/pii/S2352396420304515?via%3Dihub; Barad M, Csukasi F, Bosakova M, Martin JH, Zhang W, Paige Taylor S, et al. Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia. EBioMedicine. 2020 Dec;62:103075; http://hdl.handle.net/10668/3923; PMC7695969

Διαθεσιμότητα: http://hdl.handle.net/10668/3923
https://doi.org/10.1016/j.ebiom.2020.103075

Dual functionality of the amyloid protein TasA in Bacillus physiology and fitness on the phylloplane

Συγγραφείς: Cámara-Almirón, Jesús, Navarro, Yurena, Díaz-Martínez, Luis, Magno-Pérez-Bryan, María Concepción, Molina-Santiago, Carlos, Pearson, John R., de Vicente, Antonio, Pérez-García, Alejandro, Romero, Diego

Συνεισφορές: Cámara-Almirón,J, Navarro,Y, Díaz-Martínez,L, Magno-Pérez-Bryan,MC, Molina-Santiago,C, de Vicente,A, Pérez-García,A, Romero,D Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” – Departamento de Microbiología, Universidad de Málaga, Málaga, Spain. Pearson,JR Nano-imaging Unit, Andalusian Centre for Nanomedicine and Biotechnology, BIONAND, Málaga, Spain., C.M.S is funded by the program Juan de la Cierva Formación (FJCI-2015-23810). This work was supported by grants from ERC Starting Grant (BacBio 637971) and Plan Nacional de I+D+I of Ministerio de Economía y Competitividad (AGL2016-78662-R).

Θεματικοί όροι: Bacillus subtilis, Bacterial proteins, Bacteria, Amyloidogenic proteins, Cell death, Cell membrane, Proteínas bacterianas, Bacterias, Proteínas amiloidogénicas, Muerte celular, Membrana celular, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Amyloid::Amyloidogenic Proteins, Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Bacillales::Bacillaceae::Bacillus, Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Bacillales::Bacillaceae::Bacillus::Bacillus subtilis, Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Bacterial Physiological Phenomena::Bacterial Processes::Bacterial Adhesion, and Proteins::Proteins::Bacterial Proteins, Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Biofilms, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death, Medical Subject Headings::Anatomy::Cells::Cellular Structures::Cell Membrane, Medical Subject Headings::Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Cucurbitaceae, Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Ecology, Medical Subject Headings::Chemicals and Drugs::Lipids::Lipopeptides, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic::Transcriptome

Περιγραφή αρχείου: application/pdf; application/vnd.openxmlformats-officedocument.spreadsheetml.sheet

Relation: https://www.nature.com/articles/s41467-020-15758-z; Cámara-Almirón J, Navarro Y, Díaz-Martínez L, Magno-Pérez-Bryan MC, Molina-Santiago C, Pearson JR, et al. Dual functionality of the amyloid protein TasA in Bacillus physiology and fitness on the phylloplane. Nat Commun. 2020 Apr 20;11(1):1859; http://hdl.handle.net/10668/3676; PMC7171179

Διαθεσιμότητα: http://hdl.handle.net/10668/3676
https://doi.org/10.1038/s41467-020-15758-z

Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage

Συγγραφείς: Ortega, Pedro, García-Pichardo, Desiré, San Martin-Alonso, Marta, Rondón, Ana G., Gómez-González, Belén, Aguilera, Andrés

Συνεισφορές: Ortega,P, García-Pichardo,D, San Martin-Alonso,M, Rondón, AG, Gómez-González,B, Aguilera,A Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain., Research was supported by the Euro-pean Research Council (ERC2014 AdG669898 TARLOOP), the Spanish Ministry of Economy and Competitiveness (BFU2016-75058-P), the Foundation Vencer el Cáncer and the European Union (FEDER). P. O. was supported by a predoctoral training grant from the Spanish Ministry of Economy and Competitiveness and B.G.-G. by the Span-ish Association Against Cancer (AECC).

Θεματικοί όροι: Chromatin, DNA replication, Recombination, Histone mutants, Cromatina, Replicación del ADN, Recombinación genética, Histonas, Mutación, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histones, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Replication, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Chromosome Structures::Chromatin

Περιγραφή αρχείου: application/pdf

Relation: http://microbialcell.com/researcharticles/2020a-ortega-microbial-cell/; Ortega P, García-Pichardo D, San Martin-Alonso M, Rondón AG, Gómez-González B, Aguilera A. Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. Microb Cell. 2020 Apr 24;7(7):190-198.; http://hdl.handle.net/10668/3568; PMC7328676

Διαθεσιμότητα: http://hdl.handle.net/10668/3568
https://doi.org/10.15698/mic2020.07.723