Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

Συγγραφείς: Gonzalez-Cano, Rafael, Montilla-García, Ángeles, Perazzoli, Gloria, Torres, Jesús M., Cañizares, Francisco J., Fernández-Segura, Eduardo, Costigan, Michael, Baeyens, José M., Cobos, Enrique J.

Συνεισφορές: Gonzalez-Cano,R, Montilla-García,A, Baeyens,JM, Cobos,EJ Department of Pharmacology, Faculty of Medicine, University of Granada, Granada, Spain. Gonzalez-Cano,R, Torres,JM, Cañizares,FJ, Fernández-Segura,E, Cobos,EJ Institute of Neuroscience, Biomedical Research Center, University of Granada, Granada, Spain. Gonzalez-Cano,R, Cobos,EJ Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. Perazzoli,G Department of Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. Torres,JM Department of Biochemistry, Molecular Biology and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Cañizares,FJ, Fernández-Segura,E Department of Histology, Faculty of Medicine, University of Granada, Granada, Spain. Costigan,M Departments of Anesthesia and Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Cobos,EJ Teófilo Hernando Institute for Drug Discovery, Madrid, Spain., This study was partially supported by the Spanish State Research Agency (10.13039/501100011033) under the auspices of MINECO (grant number PID2019-108691RB-I00), and by the Junta de Andalucía (grant CTS-109).

Θεματικοί όροι: Mustard oil, Visceral pain, Resiniferatoxin, TRPA1, TRPV1, P2X, Dolor visceral, Hyperalgesia, Hiperalgesia, Nociceptors, Nociceptores, Abdominal wall, Pared abdominal, Spinal cord, Médula espinal, Medical Subject Headings::Diseases::Nervous System Diseases::Neurologic Manifestations::Sensation Disorders::Somatosensory Disorders::Hyperalgesia, Medical Subject Headings::Anatomy::Cells::Neurons::Neurons, Afferent::Sensory Receptor Cells::Nociceptors, Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Irritants, Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Nociceptive Pain::Visceral Pain, Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Perception::Pain Perception::Nociception, Medical Subject Headings::Anatomy::Body Regions::Torso::Abdomen::Abdominal Wall, Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purine Nucleotides::Adenine Nucleotides::Adenosine Triphosphate, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Spinal Cord, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Ligand-Gated Ion Channels::Receptors, Purinergic P2X

Περιγραφή αρχείου: application/pdf

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2020.613068/full; Gonzalez-Cano R, Montilla-García Á, Perazzoli G, Torres JM, Cañizares FJ, Fernández-Segura E, et al. Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors. Front Pharmacol. 2021 Jan 21;11:613068; http://hdl.handle.net/10668/4002; PMC7859884

Διαθεσιμότητα: http://hdl.handle.net/10668/4002
https://doi.org/10.3389/fphar.2020.613068

Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury

Συγγραφείς: Santos-Nogueira, Eva, López-Serrano, Clara, Hernández, Joaquim, Lago, Natalia, Astudillo, Alma M, Balsinde, Jesús, Estivill-Torrús, Guillermo, Rodríguez de Fonseca, Fernando, Chun, Jerold, López-Vales, Rubèn

Συνεισφορές: [Santos-Nogueira,E, López-Serrano,C, Hernández,J, López-Vales,R] Department of Cellular Biology, Physiology, and Immunology, Institute of Neurosciences, Center for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED), Universitat Autónoma de Barcelona, Spain. [Lago,N] Neuroinflammation and Gene Therapy Laboratory, Pasteur Institute of Montevideo, Montevideo, Uruguay. [Astudillo,AM, Balsinde,J] Institute of Biology and Molecular Genetics, Spanish National Research Council, Valladolid, Spain. [Estivill-Torrús,G, Rodríguez de Fonseca,F] Research Laboratories, Interdepartmental Neuroscience and Mental Health Clinical Management Units, Institute for Biomedical Research of Málaga, Regional University Hospital of Málaga and Virgen de la Victoria, Málaga, Spain. [Chun,J] Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, Scripps Research Institute, La Jolla, California., This work was supported by National Institutes of Health Grant NS084398 (J.C.), Wings for Life Foundation, Marie-Curie International Reintegration Program Grant MC IRG 249274, Spanish Ministry of Economy and Competitiveness Grant SAF2013-48431-R, and the Health Research Fund of Spain [Cell Therapy Network and Center for Biomedical Research in Neurodegenerative Diseases Network (CIBERNED)] (R.L-V.) E.S.-N. is a recipient from a FPU fellowship.. We thank Bristol-Myers Squibb for the gift of AM095, National Institutes of Health (US), Ministerio de Economía y Competitividad (España), MetLife Foundation, Instituto de Salud Carlos III, European Commission, Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]

Πηγή: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
instname
Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)

Θεματικοί όροι: 0301 basic medicine, Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Electrophysiological Phenomena::Evoked Potentials, Time Factors, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal, Medical Subject Headings::Diseases::Nervous System Diseases::Demyelinating Diseases, Mice, Transgenic, Spinal cord injury, Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Newborn, Motor Activity, Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Spinal Cord, Mice, 03 medical and health sciences, Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity, Medical Subject Headings::Chemicals and Drugs::Lipids::Membrane Lipids::Phospholipids, Animals, Receptors, Lysophosphatidic Acid, Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL, Medical Subject Headings::Anatomy::Cells::Neuroglia::Oligodendroglia, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex, Cells, Cultured, Spinal Cord Injuries, Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Genetically Modified::Mice, Transgenic, Cerebral Cortex, Cell Death, Oligodendrocytes, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice, Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factors, Medical Subject Headings::Check Tags::Female, Medical Subject Headings::Anatomy::Cells::Neuroglia::Microglia, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Lysophospholipid::Receptors, Lysophosphatidic Acid, Evoked Potentials, Motor, Neuroprotection, Medical Subject Headings::Anatomy::Cells::Cells, Cultured, Mice, Inbred C57BL, Medical Subject Headings::Organisms::Eukaryota::Animals, Disease Models, Animal, Oligodendroglia, Animals, Newborn, Spinal Cord, Medical Subject Headings::Diseases::Wounds and Injuries::Spinal Cord Injuries, Female, Microglia, Demyelination, Lysophospholipids, Lysophosphatidic acid, Demyelinating Diseases

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.jneurosci.org/content/jneuro/35/28/10224.full.pdf
https://pubmed.ncbi.nlm.nih.gov/26180199
http://hdl.handle.net/10668/2219
http://hdl.handle.net/10261/157654
https://www.repositoriosalud.es/bitstream/10668/2219/1/SantosNogueiraE_ActivationOfLysophosphatidic.pdf
https://digital.csic.es/handle/10261/157654
https://www.jneurosci.org/content/jneuro/35/28/10224.full.pdf
https://europepmc.org/articles/PMC4502263
http://www.jneurosci.org/content/35/28/10224.full.pdf
https://www.ncbi.nlm.nih.gov/pubmed/26180199
https://hdl.handle.net/10668/2219

Estudio de las subpoblaciones linfocitarias y secreción intratecal en pacientes con esclerosis múltiple defnida ; Study of lymphocyte subpopulations and intrathecal secretion in patients with defnite multiple sclerosis

Συγγραφείς: Arrobas Velilla, Teresa, García Sánchez, María Isabel, Sánchez Margalet, Víctor, Izquierdo Ayuso, Guillermo, Fabiani Romero, Fernando

Συνεισφορές: Arrobas Velilla,T Facultad de Medicina de la Universidad Autónoma de Chile, Sede Talca. Chile. Arrobas Velilla,T, Sánchez Margalet,V, Fabiani Romero,F Laboratorio de Riesgo Vascular, UGC de Bioquímica Clínica, Hospital Universitario Virgen Macarena, Sevilla, España. García Sánchez,MI, Izquierdo Ayuso,G Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, Sevilla, España.

Θεματικοί όροι: Multiple sclerosis, Lymphocyte subpopulations, Oligoclonal bands, Flow cytometry, Esclerosis múltiple, Subpoblaciones linfocitarias, Bandas oligoclonales, Citometría de flujo, Medical Subject Headings::Anatomy::Cells::Antibody-Producing Cells::B-Lymphocytes, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies, Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Brain Diseases, Metabolic::Brain Diseases, Metabolic, Inborn::Hereditary Central Nervous System Demyelinating Diseases, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin G, Medical Subject Headings::Diseases::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive, Relapsing-Remitting, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Spinal Cord, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Specimen Handling::Biopsy::Spinal Puncture, Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis

Περιγραφή αρχείου: application/pdf

Relation: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572014000100005&lng=es&nrm=iso; Arrobas Velilla T, García Sánchez MI, Sánchez Margalet V, Izquierdo Ayuso G, Fabiani Romero F. Estudio de las subpoblaciones linfocitarias y secreción intratecal en pacientes con esclerosis múltiple defnida. Acta Bioquím Clín Latinoam. 2014; 48 (1): 33-8; 1852-396X (CD-ROM); http://hdl.handle.net/10668/2150

Διαθεσιμότητα: http://hdl.handle.net/10668/2150

Estudio de las subpoblaciones linfocitarias y secreción intratecal en pacientes con esclerosis múltiple defnida

Συγγραφείς: Arrobas Velilla, Teresa, García Sánchez, María Isabel, Sánchez Margalet, Víctor, Izquierdo Ayuso, Guillermo, Fabiani Romero, Fernando

Συνεισφορές: [Arrobas Velilla,T] Facultad de Medicina de la Universidad Autónoma de Chile, Sede Talca. Chile. [Arrobas Velilla,T, Sánchez Margalet,V, Fabiani Romero,F] Laboratorio de Riesgo Vascular, UGC de Bioquímica Clínica, Hospital Universitario Virgen Macarena, Sevilla, España. [García Sánchez,MI, Izquierdo Ayuso,G] Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, Sevilla, España.

Πηγή: RISalud-ANDALUCIA. Repositorio Institucional de Salud de Andalucía
instname

Θεματικοί όροι: Medical Subject Headings::Diseases::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Relapsing-Remitting, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Spinal Cord, Medical Subject Headings::Anatomy::Cells::Antibody-Producing Cells::B-Lymphocytes, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies, Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis, Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Specimen Handling::Biopsy::Spinal Puncture, Medical Subject Headings::Diseases::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive, Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Brain Diseases, Metabolic::Brain Diseases, Metabolic, Inborn::Hereditary Central Nervous System Demyelinating Diseases, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin G, Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: http://hdl.handle.net/10668/2150
https://hdl.handle.net/10668/2150