Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development

Authors: Díaz del Moral, Sandra, Barrena, Silvia, Hernández-Torres, Francisco, Aránega, Amelia, Villaescusa, José Manuel, Gómez Doblas, Juan José, Franco, Diego, Jiménez-Navarro, Manuel, Muñoz-Chápuli, Ramón, Carmona, Rita

Contributors: Díaz del Moral,S, Barrena,S, Muñoz-Chápuli,R, Carmona,R Department of Animal Biology, University of Málaga, Málaga, Spain. Hernández-Torres,F Department of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Granada, Spain. Hernández-Torres,F, Aránega,A Medina Foundation, Technology Park of Health Sciences, Granada, Spain. Aránega,A, Franco,D Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaén, Jaén, Spain. Villaescusa,JM, Gómez Doblas,JJ, Jiménez-Navarro,M Heart Area Clinical Management Unit, University Hospìtal Virgen de la Victoria, CIBERCV Enfermedades Cardiovasculares Health Institute Carlos III, Biomedical Research Institute of Malaga (IBIMA), University of Málaga, Málaga, Spain., This work was supported by: Spanish Ministry of Economy, Industry and Competitivity (BFU2017-83907-P to RM-C and RC and PID2019-107492GB-I00 to AA and DF), Consejería de Salud, Junta de Andalucía (PC0066?2017/PC-0081-2017 to RC, JV, and JG), Instituto de Salud Carlos III-TERCEL network (RD16/0011/0030 to RM-C and RC), Instituto de Salud Carlos III-CIBERCV “Enfermedades Cardiovasculares” (CB16/11/00360 to MJ-N), and Consejería de Economía yConocimiento, Junta de Andalucía (UMA18-FEDERJA-146 to RM-C and RC and FEDER-UJA to AA and DF).

Subject Terms: Wilms’ tumor suppressor gene, Cardiomyocytes, Cardiac development, Calcium homeostasis, Potassium channels, Genes del tumor de Wilms, Genes supresores de tumores, Miocitos cardíacos, Crecimiento y desarrollo, Homeostasis, Calcio, Canales de potasio, Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice, Medical Subject Headings::Anatomy::Cardiovascular System::Heart::Myocardium::Myocytes, Cardiac, Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Elements::Metals, Alkaline Earth::Calcium, Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Troponin::Troponin T, Medical Subject Headings::Anatomy::Musculoskeletal System::Muscles::Myocardium, Medical Subject Headings::Anatomy::Cardiovascular System::Heart::Pericardium, Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors, Medical Subject Headings::Diseases::Neoplasms::Neoplastic Syndromes, Hereditary::Wilms Tumor, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins::Ion Channels::Potassium Channels, Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Recessive::Genes, Tumor Suppressor

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Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.683861/full; Díaz Del Moral S, Barrena S, Hernández-Torres F, Aránega A, Villaescusa JM, Gómez Doblas JJ, et al. Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development. Front Cell Dev Biol. 2021 Jul 22;9:683861; http://hdl.handle.net/10668/4505; PMC8339973

Availability: http://hdl.handle.net/10668/4505
https://doi.org/10.3389/fcell.2021.683861