CRISPR Screening Identifies SMARCAL1 and MRN as Modulators of WRN Dependency in MSI-H Colorectal Cancer.

Authors: Ma T; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Wu J; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Li S; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Chen J; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Source: Cancer research [Cancer Res] 2026 Oct 15; Vol. 86 (20), pp. 5271-5286.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH Terms: Werner Syndrome Helicase*/genetics , Werner Syndrome Helicase*/metabolism , Werner Syndrome Helicase*/antagonists & inhibitors , Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/pathology , DNA Helicases*/genetics , DNA Helicases*/metabolism , MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/genetics , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics , DNA Repair Enzymes*/metabolism , DNA Repair Enzymes*/genetics , Microsatellite Instability*, DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; Humans ; Cell Line, Tumor ; CRISPR-Cas Systems ; Acid Anhydride Hydrolases

The PKMYT1-ALDOA axis drives chemoresistance in cholangiocarcinoma by enhancing glycolysis and MRE11 lactylation.

Authors: Wu W; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Wang J; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Yang W; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066CX, The Netherlands., Sun Z; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Sun X; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Wang Y; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Lian S; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Zheng J; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Zhou Y; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Shen W; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Hu P; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Guo J; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Wu Q; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Wang S; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066CX, The Netherlands., Jia Q; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Yuan S; Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Naval Medical University), Shanghai 200438, China., Bernards R; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066CX, The Netherlands., Qin W; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China., Jin H; State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam 1066CX, The Netherlands.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Oct 06; Vol. 123 (40), pp. e2623500123. Date of Electronic Publication: 2026 Sep 29.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

MeSH Terms: Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/drug therapy , Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/genetics , Drug Resistance, Neoplasm*/drug effects , Glycolysis*/drug effects , Bile Duct Neoplasms*/metabolism , Bile Duct Neoplasms*/drug therapy , Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/genetics , MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/genetics , Membrane Proteins*/metabolism , Membrane Proteins*/genetics , Fructose-Bisphosphate Aldolase*/metabolism , Fructose-Bisphosphate Aldolase*/genetics , Protein Serine-Threonine Kinases*/metabolism , Protein Serine-Threonine Kinases*/genetics, Cisplatin/pharmacology ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/pharmacology ; Humans ; Animals ; Cell Line, Tumor ; Mice ; Gemcitabine ; Xenograft Model Antitumor Assays ; DNA Repair ; Protein-Tyrosine Kinases

L Antigen Family Member 3 stabilizes stalled replication forks by reducing MRE11 resection to maintain genome stability.

Authors: Lyu M; Dermatology Hospital of Shandong First Medical University, Jinan, Shandong 250022, P.R. China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong 250022, P.R. China.; School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China., Yang G; School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China., Jia S; School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China., Zhang X; School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China., Li Y; School of Clinical and Basic Medical Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China., Feng Y; School of Laboratory Animal and Shandong Laboratory Animal Center, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China., Lyu X; Dermatology Hospital of Shandong First Medical University, Jinan, Shandong 250022, P.R. China.; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong 250022, P.R. China.; Science and Technology Innovation Center, Shandong First Medical University, Jinan, Shandong 250117, P.R. China.

Source: Nucleic acids research [Nucleic Acids Res] 2026 Aug 24; Vol. 54 (16).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH Terms: DNA Replication*/genetics , MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/genetics , Genomic Instability*, Humans ; Mutation

Cellular Retinoic Acid-Binding Protein 2 Promotes Ischemia-Induced Cardiac Fibroblast Activation and Fibrosis Through Suppression of MRE11-RAD50-NBS1-Mediated DNA Repair.

Authors: Su Z; Department of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing China., Shen H; Department of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing China., Sun J; Department of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing China., Kong X; Department of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing China., Sun W; Department of Cardiology The First Affiliated Hospital with Nanjing Medical University Nanjing China.

Source: Journal of the American Heart Association [J Am Heart Assoc] 2026 Aug 04; Vol. 15 (15), pp. e049049. Date of Electronic Publication: 2026 Jul 31.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE

MeSH Terms: MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/genetics , Myocardial Ischemia*/pathology , Myocardial Ischemia*/genetics , Myocardial Ischemia*/metabolism , Receptors, Retinoic Acid*/genetics , Receptors, Retinoic Acid*/metabolism , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , Myocardium*/pathology , Myocardium*/metabolism , DNA Repair Enzymes*/metabolism , DNA Repair Enzymes*/genetics , DNA Repair*, Acid Anhydride Hydrolases/metabolism ; Acid Anhydride Hydrolases/genetics ; Animals ; Humans ; Fibrosis ; Mice ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Cells, Cultured ; Signal Transduction

MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability.

Authors: Huang K; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Brault ME; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Cong K; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Azazmeh N; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Collins S; MCD, Centre de Biologie Intégrative (CBI), CNRS, Université de Toulouse, UT3, Toulouse, France., Lee S; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Lantz GA; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Raskind G; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Legube G; MCD, Centre de Biologie Intégrative (CBI), CNRS, Université de Toulouse, UT3, Toulouse, France., Beroukhim R; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Chowdhury D; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dipanjan_chowdhury@dfci.harvard.edu.

Source: Molecular cell [Mol Cell] 2026 May 21; Vol. 86 (10), pp. 1931-1944.e9. Date of Electronic Publication: 2026 Apr 16.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH Terms: MRE11 Homologue Protein*/genetics , MRE11 Homologue Protein*/metabolism , Genomic Instability* , Transcription, Genetic* , Polyadenylation*, Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Acid Anhydride Hydrolases/genetics ; Acid Anhydride Hydrolases/metabolism ; DNA Repair Enzymes/genetics ; DNA Repair Enzymes/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Animals ; Promoter Regions, Genetic ; DNA Replication ; Mice ; DNA Damage

The bacterial MRE11-RAD50 and DNA2-WRN homologs process replication forks at distinct and separate loci on the chromosome.

Authors: Spolek RL; Department of Biology, Portland State University, OR, USA., Christian PYH; Department of Biology, Portland State University, OR, USA., Courcelle CT; Department of Biology, Portland State University, OR, USA., Courcelle J; Department of Biology, Portland State University, OR, USA.

Source: FEBS letters [FEBS Lett] 2026 Feb; Vol. 600 (4), pp. 451-466. Date of Electronic Publication: 2025 Oct 30.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

MeSH Terms: Chromosomes, Bacterial*/metabolism , Escherichia coli*/metabolism , Escherichia coli Proteins*/metabolism , MRE11 Homologue Protein*/metabolism , DNA Damage Tolerance*, Acid Anhydride Hydrolases ; Werner Syndrome Helicase ; DNA-Binding Proteins ; DNA Helicases ; Deoxyribonucleases ; Exonucleases

MRE11 deacetylation by SIRT2 promotes DNA binding to facilitate DNA end resection and ATM-dependent signaling.

Authors: Sesay F; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Biology, Clark Atlanta University, Atlanta, Georgia, USA., Zhang H; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Kapoor-Vazirani P; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Jung AT; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Essien ME; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Bastien AJ; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Luong NC; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Liu X; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA., Head PE; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Duong DM; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA., Yang X; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Buchwald ZS; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Deng X; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA., Yu DS; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

Source: The Journal of clinical investigation [J Clin Invest] 2026 Jan 08; Vol. 136 (5). Date of Electronic Publication: 2026 Jan 08 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH Terms: MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/genetics , Ataxia Telangiectasia Mutated Proteins*/metabolism , Ataxia Telangiectasia Mutated Proteins*/genetics , Sirtuin 2*/metabolism , Sirtuin 2*/genetics , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/genetics , DNA*/metabolism , DNA*/genetics , Signal Transduction* , DNA Breaks, Double-Stranded*, Humans ; Acetylation ; Animals ; DNA Repair ; Protein Binding

ZBP1 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in ovarian cancer.

Authors: Shi SN; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Xu Q; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Liao Z; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Gong W; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Cui Y; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China., Liu J; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Jiao X; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wu Y; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Luo M; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhang Y; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wang L; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Wen Y; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Pan W; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhao X; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States., Labrie M; Department of Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC, Canada., Ding Z; Mills institute for Personalized Cancer Care, Fynn Biotechnologies Ltd., Jinan 250101, China., Mills GB; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, United States., Ma D; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhao GN; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: zhaogn@tjh.tjmu.edu.cn., Gao Q; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: qlgao@tjh.tjmu.edu.cn., Fang Y; Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Cancer Invasion and Metastasis (Ministry of Education), Hubei Key Laboratory of Tumor Invasion and Metastasis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: tongjify@163.com.

Source: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2026 Jan; Vol. 84, pp. 101319. Date of Electronic Publication: 2025 Oct 28.

Publication Type: Journal Article

Journal Info: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9815369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2084 (Electronic) Linking ISSN: 13687646 NLM ISO Abbreviation: Drug Resist Updat Subsets: MEDLINE

MeSH Terms: Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , Poly(ADP-ribose) Polymerase Inhibitors*/therapeutic use , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/antagonists & inhibitors , MRE11 Homologue Protein*/genetics, DNA Breaks, Double-Stranded/drug effects ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Recombinational DNA Repair/drug effects ; Female ; Humans ; Animals ; Mice ; Cell Line, Tumor ; Synthetic Lethal Mutations ; Xenograft Model Antitumor Assays ; Indazoles

Distinct Association of MRE11 and ATM Co-Expression with Clinical Outcomes in Laryngeal Cancer.

Authors: Pechacova Z; Institute of Radiation Oncology, First Faculty of Medicine, Charles University and Bulovka University Hospital, Prague, Czechia, zdenka.pechacova@bulovka.cz., Lohynska R; Department of Oncology, First Faculty of Medicine, Charles University and Thomayer University Hospital, Prague, Czechia., Spurkova Z; Department of Pathology and Anatomy, Bulovka University Hospital, Prague, Czechia., Sedivec V; Bioptical Laboratory Ltd, Pilsen, Czechia., Svajdler M; Bioptical Laboratory Ltd, Pilsen, Czechia., Drbohlavova T; Institute of Radiation Oncology, First Faculty of Medicine, Charles University and Bulovka University Hospital, Prague, Czechia., Tesarova P; Institute of Radiation Oncology, First Faculty of Medicine, Charles University and Bulovka University Hospital, Prague, Czechia., Pala M; Institute of Radiation Oncology, First Faculty of Medicine, Charles University and Bulovka University Hospital, Prague, Czechia.

Source: Oncology [Oncology] 2026; Vol. 104 (9), pp. 1102-1114. Date of Electronic Publication: 2026 Mar 17.

Publication Type: Journal Article

Journal Info: Publisher: Karger Country of Publication: Switzerland NLM ID: 0135054 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0232 (Electronic) Linking ISSN: 00302414 NLM ISO Abbreviation: Oncology Subsets: MEDLINE

MeSH Terms: Ataxia Telangiectasia Mutated Proteins*/metabolism , MRE11 Homologue Protein*/metabolism , Laryngeal Neoplasms*/radiotherapy , Laryngeal Neoplasms*/pathology , Laryngeal Neoplasms*/metabolism , Laryngeal Neoplasms*/mortality, Biomarkers, Tumor/metabolism ; Humans ; Female ; Retrospective Studies ; Male ; Aged ; Middle Aged ; Treatment Outcome ; Immunohistochemistry ; Aged, 80 and over ; Adult ; Prognosis ; Neoplasm Staging

Molecular characterisation of Toxoplasma gondii Mre11 reveals unique structural features and potential as a therapeutic target.

Authors: Ruiz DM; Instituto de Ciencia y Tecnología de Alimentos y Ambiente (INCITAA), Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC) - Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Argentina. dmruiz@mdp.edu.ar., Turowski VR; Instituto de Investigaciones Biológicas (IIB), Consejo Nacional de Investigaciones Científicas (CONICET) - Universidad Nacional de Mar del Plata (UNMdP), Mar del Plata, Argentina. vturowski@mdp.edu.ar., Sullivan WJ Jr; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA., Angel SO; Instituto Tecnológico de Chascomús (CONICET-UNSAM), Chascomús, Provincia de Buenos Aires, Argentina.; Escuela de Bio y Nanotecnologías (UNSAM), San Martín, Argentina.

Source: Scientific reports [Sci Rep] 2025 Dec 17; Vol. 15 (1), pp. 43994. Date of Electronic Publication: 2025 Dec 17.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

MeSH Terms: Toxoplasma*/enzymology , Toxoplasma*/genetics , Protozoan Proteins*/chemistry , Protozoan Proteins*/metabolism , Protozoan Proteins*/genetics , MRE11 Homologue Protein*/chemistry , MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/genetics, Humans ; DNA Repair ; Models, Molecular ; Amino Acid Sequence

Differential expression of a disease-associated MRE11 variant reveals distinct phenotypic outcomes.

Authors: DeFoer MB; Department of Human Genetics, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2063, Ann Arbor, MI 48109-2200, United States., Mostafa AM; Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2067, Ann Arbor, MI 48109-2200, United States.; Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, African Union Authority St., Abbassia, Cairo 11566, Egypt., Hartlerode AJ; Department of Human Genetics, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2063, Ann Arbor, MI 48109-2200, United States.; Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2067, Ann Arbor, MI 48109-2200, United States., Orban SK; Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2067, Ann Arbor, MI 48109-2200, United States., McDonough K; Department of Human Genetics, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2063, Ann Arbor, MI 48109-2200, United States., Quirk S; Department of Human Genetics, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2063, Ann Arbor, MI 48109-2200, United States., Ferguson BKL; Department of Human Genetics, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2063, Ann Arbor, MI 48109-2200, United States.; Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2067, Ann Arbor, MI 48109-2200, United States., Ferguson DO; Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2067, Ann Arbor, MI 48109-2200, United States., Sekiguchi JM; Department of Human Genetics, University of Michigan Medical School, 109 Zina Pitcher Place, Rm 2063, Ann Arbor, MI 48109-2200, United States.

Source: Human molecular genetics [Hum Mol Genet] 2025 Nov 18; Vol. 34 (23), pp. 1964-1978.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

MeSH Terms: MRE11 Homologue Protein*/genetics , MRE11 Homologue Protein*/metabolism , Ataxia Telangiectasia*/genetics , Ataxia Telangiectasia*/pathology, DNA Repair/genetics ; DNA-Binding Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Cycle Proteins/genetics ; DNA Repair Enzymes/genetics ; Humans ; Animals ; Mice ; DNA Breaks, Double-Stranded ; Phenotype ; Mice, Transgenic ; Acid Anhydride Hydrolases

An IRAK1-snRNA axis activates ATM to promote accurate repair within transcriptionally active chromatin.

Authors: Nie C; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Frontiers Science Center for Cancer Integrative Omics, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China., Liu W; Department of Laboratory Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China. Electronic address: lwc191@163.com., Zhang L; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Frontiers Science Center for Cancer Integrative Omics, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China., Ge S; Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China; Department of Rare Tumors and Early-Phase Clinical Research, Peking University Cancer Hospital (Inner Mongolia Campus), Affiliated Cancer Hospital of Inner Mongolia Medical University, Hohhot, China., Ma M; Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Key Laboratory of Digital Intelligence Hepatology (Ministry of Education/Beijing), School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China., Wang J; Department of Oncology, Peking University First Hospital, Beijing, China., Xu Z; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Frontiers Science Center for Cancer Integrative Omics, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China., Qin Y; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Frontiers Science Center for Cancer Integrative Omics, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China., Zhou XA; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Frontiers Science Center for Cancer Integrative Omics, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China., Liu Y; Department of Medical Genetics, Center for Medical Genetics, School of Basic Medical Sciences, Peking University, Beijing, China., Wang W; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Frontiers Science Center for Cancer Integrative Omics, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China., Wang J; Department of Radiation Medicine, School of Basic Medical Sciences, Peking University International Cancer Institute, Frontiers Science Center for Cancer Integrative Omics, Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, Peking University Health Science Center, Beijing, China; Department of Gastrointestinal Translational Research, Peking University Cancer Hospital, Beijing, China; Department of Urology, Peking University First Hospital, Beijing, China. Electronic address: wangjd@bjmu.edu.cn.

Source: Molecular cell [Mol Cell] 2026 Sep 17; Vol. 86 (18), pp. 3655-3672.e17. Date of Electronic Publication: 2026 Aug 31.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

MeSH Terms: Interleukin-1 Receptor-Associated Kinases*/metabolism , Interleukin-1 Receptor-Associated Kinases*/genetics , Ataxia Telangiectasia Mutated Proteins*/metabolism , Ataxia Telangiectasia Mutated Proteins*/genetics , Chromatin*/genetics , Chromatin*/metabolism , RNA, Small Nuclear*/genetics , RNA, Small Nuclear*/metabolism , Transcription, Genetic* , Recombinational DNA Repair*, Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Nuclear Proteins/metabolism ; Nuclear Proteins/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; DNA Repair Enzymes/metabolism ; DNA Repair Enzymes/genetics ; MRE11 Homologue Protein/metabolism ; MRE11 Homologue Protein/genetics ; Spliceosomes/genetics ; Spliceosomes/metabolism ; Humans ; DNA Breaks, Double-Stranded ; Phosphorylation ; Cell Line, Tumor ; Acid Anhydride Hydrolases

MRE11 suppresses germline mutagenesis at meiotic double-strand breaks in mice.

Authors: Lukaszewicz A; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA; lukaszea@med.umich.edu s-keeney@ski.mskcc.org jasinm@mskcc.org., Wilson TE; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA., Kim S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Keeney S; Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; lukaszea@med.umich.edu s-keeney@ski.mskcc.org jasinm@mskcc.org.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center New York, New York 10065, USA., Jasin M; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA lukaszea@med.umich.edu s-keeney@ski.mskcc.org jasinm@mskcc.org.

Source: Genes & development [Genes Dev] 2026 Aug 26; Vol. 40 (17-18), pp. 1466-1483. Date of Electronic Publication: 2026 Aug 26.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Electronic Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

MeSH Terms: Meiosis*/genetics , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Mutagenesis*/genetics , Germ-Line Mutation*/genetics , DNA Breaks, Double-Stranded*, Spermatocytes/metabolism ; Endodeoxyribonucleases/metabolism ; Endodeoxyribonucleases/genetics ; DNA End-Joining Repair/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Animals ; Mice ; Meiotic Recombination Protein SPO11 ; Male ; MRE11 Homologue Protein

Nucleostemin promotes RAD51 filament assembly on double-stranded DNA to protect stalled replication forks.

Authors: Chang CC; Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan., Tsai SS; Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan., Chou CL; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.; Department of Pharmacy, National Taiwan University, Taipei 106, Taiwan., Chang YH; Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan., Hung CT; Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan., Tsai RYL; Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX 77030, United States.; Department of Translational Medical Sciences, College of Medicine, Texas A&M University Health Science Center, Houston, TX 77030, United States., Li HW; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan., Liaw H; Department of Life Sciences, National Cheng Kung University, Tainan 701, Taiwan., Chi P; Institute of Biochemical Sciences, National Taiwan University, Taipei 106, Taiwan.; Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.

Source: Nucleic acids research [Nucleic Acids Res] 2026 Aug 10; Vol. 54 (15).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

MeSH Terms: Rad51 Recombinase*/metabolism , Rad51 Recombinase*/genetics , DNA Replication*/genetics , DNA*/metabolism , DNA*/genetics , GTP-Binding Proteins*/metabolism , GTP-Binding Proteins*/genetics , Nuclear Proteins*/metabolism , Nuclear Proteins*/genetics, MRE11 Homologue Protein/metabolism ; MRE11 Homologue Protein/genetics ; DNA-Binding Proteins/metabolism ; Hydroxyurea/pharmacology ; DNA, Single-Stranded/metabolism ; DNA, Single-Stranded/genetics ; Humans

Structural basis for DNA break sensing by human MRE11-RAD50-NBS1 and its regulation by telomeric factor TRF2.

Authors: Fan Y; Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377, Munich, Germany., Kuybu F; Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377, Munich, Germany., Cui H; Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377, Munich, Germany., Lammens K; Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377, Munich, Germany., Chen JX; Proteomics Core Facility, Institute of Molecular Biology, Mainz, Germany., Kugler M; Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377, Munich, Germany., Jung C; Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377, Munich, Germany., Hopfner KP; Gene Center, Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor Lynen Straße 25, 81377, Munich, Germany. karlpeter.hopfner@lmu.de.

Source: Nature communications [Nat Commun] 2025 Sep 18; Vol. 16 (1), pp. 8320. Date of Electronic Publication: 2025 Sep 18.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/chemistry , MRE11 Homologue Protein*/genetics , MRE11 Homologue Protein*/ultrastructure , Telomeric Repeat Binding Protein 2*/metabolism , Telomeric Repeat Binding Protein 2*/chemistry , Telomeric Repeat Binding Protein 2*/genetics , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/chemistry , Cell Cycle Proteins*/genetics , Cell Cycle Proteins*/ultrastructure , DNA-Binding Proteins*/metabolism , DNA-Binding Proteins*/chemistry , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/ultrastructure , Nuclear Proteins*/metabolism , Nuclear Proteins*/chemistry , Nuclear Proteins*/genetics , Nuclear Proteins*/ultrastructure , DNA Repair Enzymes*/metabolism , DNA Repair Enzymes*/chemistry , DNA Repair Enzymes*/genetics , DNA Repair Enzymes*/ultrastructure , DNA Breaks, Double-Stranded*, DNA/metabolism ; Acid Anhydride Hydrolases/metabolism ; Telomere/metabolism ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Humans ; Cryoelectron Microscopy ; Protein Binding

Saikosaponin D Mitigates Radioresistance in Triple-Negative Breast Cancer by Inducing MRE11 De-Lactylation via HIF1α/HDAC5 Pathway.

Authors: Li J; Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China.; Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China., Feng L; School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China., Zhang L; Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China., Zhang W; Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China., Zhang Y; School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China., Liu X; School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China., Cai Q; Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China., Zhao W; Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China., Huang G; Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China., Lu C; Shanghai Key Laboratory of Molecular Imaging, Jiading District Central Hospital Affiliated Shanghai University of Medicine and Health Sciences, Shanghai, China.; School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, China.

Source: Theranostics [Theranostics] 2025 Aug 11; Vol. 15 (17), pp. 8935-8951. Date of Electronic Publication: 2025 Aug 11 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101552395 Publication Model: eCollection Cited Medium: Internet ISSN: 1838-7640 (Electronic) Linking ISSN: 18387640 NLM ISO Abbreviation: Theranostics Subsets: MEDLINE

MeSH Terms: Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/drug therapy , Triple Negative Breast Neoplasms*/radiotherapy , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/genetics , Saponins*/pharmacology , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Radiation Tolerance*/drug effects , Histone Deacetylases*/metabolism , Histone Deacetylases*/genetics , Oleanolic Acid*/analogs & derivatives , Oleanolic Acid*/pharmacology , MRE11 Homologue Protein*/metabolism , MRE11 Homologue Protein*/genetics , Radiation-Sensitizing Agents*/pharmacology, Signal Transduction/drug effects ; DNA Repair/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Cell Line, Tumor ; Female ; Animals ; Mice

Mechanosensors Collaborate to Regulate DNA Damage Repair in Hepatocellular Carcinoma.

Authors: Li J; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China.; Department of Gastroenterology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, PR China., Ren Z; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Yao J; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Zhao Y; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Xu Y; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Yu H; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Huang C; Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai, PR China., Wang M; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Yao F; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Li M; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Wang Y; Department of Radiology, Shanghai Cancer Center, Fudan University, Shanghai, PR China., Gao D; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Zhao Y; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Liu B; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Wang Z; Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, PR China., Dong Y; Department of Radiation Oncology, The Affiliated Hospital of Qingdao University, Qingdao, PR China., Chen R; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China., Cui J; Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, PR China.

Source: Cancer research [Cancer Res] 2026 Oct 15; Vol. 86 (20), pp. 5043-5062.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

MeSH Terms: Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Liver Neoplasms*/pathology , DNA Repair* , DNA Damage* , Mechanotransduction, Cellular*, Nuclear Proteins/metabolism ; DNA-Binding Proteins/metabolism ; Protein Phosphatase 2/metabolism ; Cell Cycle Proteins/metabolism ; Humans ; Cell Line, Tumor ; Phosphorylation ; MRE11 Homologue Protein

BTAF1: a key regulator of DNA end resection and predictor of chemotherapy sensitivity in gastric cancer.

Authors: Xie JJ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.; Department of Gastroenterology and Hepatology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China., Lin JL; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China., Xiang ZC; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China., Qu CH; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China., Cai XX; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China., Nie RC; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.; Department of Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China., Lin P; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China.; Department of Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China., Yin YX; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China., Duan JL; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. duanjl@sysucc.org.cn.; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China. duanjl@sysucc.org.cn., Xie D; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. xiedan@sysucc.org.cn.; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China. xiedan@sysucc.org.cn., Cai MY; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, PR China. caimy@sysucc.org.cn.; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China. caimy@sysucc.org.cn.

Source: Cell death and differentiation [Cell Death Differ] 2026 Oct; Vol. 33 (10), pp. 1994-2006. Date of Electronic Publication: 2026 Mar 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE

MeSH Terms: Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/genetics , Stomach Neoplasms*/pathology , Stomach Neoplasms*/metabolism, MRE11 Homologue Protein/metabolism ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Humans ; Animals ; Cell Line, Tumor ; DNA Breaks, Double-Stranded ; Mice ; Drug Resistance, Neoplasm

Nuclear localization of the glutaminyl-tRNA synthetase QARS reveals its role in DNA damage response in ovarian cancer.

Authors: Serafini M; Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France., Di Fazio F; Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France.; Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy., Kieffer Y; Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France., Djerroudi L; Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France.; Institut Curie, Department of Diagnostic and Theranostic Medicine, PSL Research University, 26, rue d'Ulm, Paris, France., Dec L; Institut Curie, PSL Research University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France., Richard M; Institut Curie, PSL Research University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France., Aubert Y; University of Toulouse, Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, CHU Purpan, Toulouse, France., Marchesoni-Acland F; Université Paris-Saclay, ENS Paris-Saclay, CNRS UMR9010, Centre Borelli, Gif-sur-Yvette, France., Diaz-Munoz MD; University of Toulouse, Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, CHU Purpan, Toulouse, France., Vincent-Salomon A; Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France.; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France.; Institut Curie, Department of Diagnostic and Theranostic Medicine, PSL Research University, 26, rue d'Ulm, Paris, France., Vagner S; Institut Curie, PSL Research University, CNRS UMR3348, Inserm, Orsay, France., Loew D; Institut Curie, PSL Research University, CurieCoreTech Mass Spectrometry Proteomics, Paris, France., Ceccaldi R; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France.; Alternative DNA repair mechanisms in human cancers, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France., Mechta-Grigoriou F; Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France. fatima.mechta-grigoriou@curie.fr.; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France. fatima.mechta-grigoriou@curie.fr., Mieulet V; Stress and Cancer Laboratory, Equipe labélisée par la Ligue Nationale contre le Cancer, Institut Curie, PSL Research University, 26, rue d'Ulm, Paris, France. virginie.mieulet@inserm.fr.; Inserm U1339, CNRS UMR3666, 26 rue d'Ulm, Paris, France. virginie.mieulet@inserm.fr.; University of Toulouse, Toulouse Institute for Infectious and Inflammatory Diseases (INFINITy), Inserm UMR1291, CNRS UMR5051, CHU Purpan, Toulouse, France. virginie.mieulet@inserm.fr.

Source: Nature communications [Nat Commun] 2026 Aug 07; Vol. 17 (1). Date of Electronic Publication: 2026 Aug 07.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

MeSH Terms: Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/enzymology , Cell Nucleus*/metabolism , Amino Acyl-tRNA Synthetases*/metabolism , Amino Acyl-tRNA Synthetases*/genetics , DNA Damage*, Autoantigens/metabolism ; Antigens, Nuclear/metabolism ; Chromatin/metabolism ; Humans ; Female ; DNA Repair ; Cell Line, Tumor ; Homologous Recombination ; MRE11 Homologue Protein

ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma.

Authors: Ye S; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China.; Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China., Xu W; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Chen Z; State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan University, 200433, Shanghai, China., Zhu C; Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China., Ge Q; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Lu J; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Chang K; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Tian X; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Anwaier A; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Zhu S; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Zhou S; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Zhang W; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Wang Y; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Zhao J; Institute for Developmental and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China., Li L; State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan University, 200433, Shanghai, China., Shi Y; Institute for Developmental and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 200092, Shanghai, China., Cai T; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China., Xu D; Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. xdf12036@rjh.com.cn., Zhou X; Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, 200433, Shanghai, China. husq04@163.com., Ye D; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China. dingwei_ye@fudan.edu.cn., Zhang H; Department of Urology, Huadong Hospital, Fudan University; Department of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Genitourinary Cancer Institute, Fudan University, 200040, Shanghai, China. zhanghl918@163.com.

Source: Molecular cancer [Mol Cancer] 2025 Oct 21; Vol. 24 (1), pp. 263. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

MeSH Terms: Carcinoma, Renal Cell*/metabolism , Carcinoma, Renal Cell*/pathology , Carcinoma, Renal Cell*/immunology , Carcinoma, Renal Cell*/drug therapy , Carcinoma, Renal Cell*/genetics , MRE11 Homologue Protein*/metabolism , Nucleotidyltransferases*/metabolism , DNA-Binding Proteins*/metabolism , Kidney Neoplasms*/metabolism , Kidney Neoplasms*/pathology , Kidney Neoplasms*/immunology , Kidney Neoplasms*/drug therapy , Kidney Neoplasms*/genetics , Acid Anhydride Hydrolases*/metabolism , DNA Repair Enzymes*/metabolism , Membrane Proteins*/metabolism , Cell Cycle Proteins*/metabolism , Nuclear Proteins*/metabolism, Humans ; cGAS-STING Signaling Pathway ; Animals ; Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase ; STING Protein ; Mice ; Cell Line, Tumor ; Signal Transduction ; Gene Expression Regulation, Neoplastic ; Xenograft Model Antitumor Assays