Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice

Συγγραφείς: Zumerle, Sara, Sarill, Miles, Saponaro, Miriam, Colucci, Manuel, Contu, Liliana, Lazzarini, Edoardo, Sartori, Roberta, Pezzini, Camilla, Rinaldi, Anna, Scanu, Anna, Sgrignani, Jacopo, Locatelli, Patrizia, Sabbadin, Marianna, Valdata, Aurora, Brina, Daniela, Giacomini, Isabella, Rizzo, Beatrice, Pierantoni, Alessandra, Sharifi, Saman, Bressan, Silvia, Altomare, Claudia, Goshovska, Yulia, Giraudo, Chiara, Luisetto, Roberto, Iaccarino, Luca, Torcasio, Cristina, Mosole, Simone, Pasquini, Emiliano, Rinaldi, Andrea, Pellegrini, Laura, Peron, Gregorio, Fassan, Matteo, Masiero, Stefano, Giori, Andrea Maria, Dall'Acqua, Stefano, Auwerx, Johan, Cippà, Pietro, Cavalli, Andrea, Bolis, Marco, Sandri, Marco, Barile, Lucio, Montopoli, Monica, Alimonti, Andrea

Πηγή: Nat Aging
Nature aging, vol. 4, no. 9, pp. 1231-1248

Θεματικοί όροι: Male, 0301 basic medicine, Aging, 0303 health sciences, Plant Extracts, Longevity, Polyphenols, Article, 3. Good health, Aging, botanical extracts, healthspan, Mice, 03 medical and health sciences, Doxorubicin, Animals, Longevity/drug effects, Plant Extracts/pharmacology, Cellular Senescence/drug effects, Polyphenols/pharmacology, Salvia/chemistry, Aging/drug effects, Doxorubicin/pharmacology, Cyclin-Dependent Kinase Inhibitor p16/metabolism, Cyclin-Dependent Kinase Inhibitor p16/genetics, Luteolin/pharmacology, Salvia, Luteolin, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38951692
https://serval.unil.ch/notice/serval:BIB_F01027CE166C
https://serval.unil.ch/resource/serval:BIB_F01027CE166C.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F01027CE166C0

Mimetic AI & NAD⁺: A Polymorphic Injector for Longevity Science, Industry, and Society

Συγγραφείς: Tabary, Frédéric

Θεματικοί όροι: MTOR Inhibitors/administration & dosage, #EpigeneticClock, MTOR Inhibitors/standards, Sirtuins/pharmacokinetics, MTOR Inhibitors/isolation & purification, Sirtuins/genetics, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/analysis, (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride/administration & dosage, MTOR Inhibitors/history, MTOR Inhibitors/metabolism, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/metabolism, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/history, MTOR Inhibitors/therapeutic use, MTOR Inhibitors/urine, Sirtuins/deficiency, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/biosynthesis, MTOR Inhibitors/chemistry, MTOR Inhibitors/pharmacology, MTOR Inhibitors/blood, (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride, Longevity/genetics, Sirtuins/classification, #IA_Mimétique, Sirtuins/urine, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/ultrastructure, zoran, Longevity/ethics, MTOR Inhibitors/immunology, Longevity, #Geroprotectors, Longevity/physiology, longevity standards, Sirtuins/physiology, SilverEconomyAI, OpenSourceAI, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases, Sirtuins/blood, MTOR Inhibitors/analysis, LongevityDigitalTwins, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/pharmacology, MTOR Inhibitors/poisoning, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/standards, LongevityAI, Sirtuins/metabolism, MTOR Inhibitors/toxicity, (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride/adverse effects, NAD, Sirtuins/chemistry, Sirtuins/poisoning, Compliance/physiology, Resveratrol, #CellularReprogramming, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/pharmacokinetics, Sirtuins/history, Sirtuins/pharmacology, Sirtuins/biosynthesis, Sirtuins/economics, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/physiology, MTOR Inhibitors/pharmacokinetics, Sirtuins, MTOR Inhibitors/classification, Zoran IA mimetique, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/toxicity, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/economics, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/urine, MTOR Inhibitors, Sirtuins/ultrastructure, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/genetics, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/chemistry, mTOR, MTOR Inhibitors/chemical synthesis, BiomimeticPeptides, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/classification, Compliance, Longevity/drug effects, #MimeticAI, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/immunology, Sirtuins/standards, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/blood, #LongevityStandards, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/poisoning, NR, AICompliance, AIforHealthspan, Sirtuins/toxicity, NMN, Longevity/radiation effects, NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases/deficiency, Longevity/immunology, Sirtuins/immunology, MTOR Inhibitors/cerebrospinal fluid, Patient Compliance, MTOR Inhibitors/economics, #MultiOmicsAI, Sirtuins/analysis

Spermidine supplementation and protein restriction protect from organismal and brain aging independently

Συγγραφείς: Liang, YongTian, Krivograd, Anja, Hofer, Sebastian J, Kollipara, Laxmikanth, Züllig, Thomas, Sickmann, Albert, Eisenberg, Tobias, Sigrist, Stephan J

Πηγή: Aging (Albany NY)
Aging 17(6), 1429-1451 (2025). doi:10.18632/aging.206267

Θεματικοί όροι: Male, Aging, Spermidine, Longevity, Peptide Initiation Factors: metabolism, Peptide Initiation Factors, spermidine, Diet, Protein-Restricted, Aging: physiology, Animals, Drosophila Proteins, protein restriction, Aging: drug effects, Mitochondria: drug effects, Brain: drug effects, Spermidine: administration & dosage, Drosophila Proteins: metabolism, aging, Brain, Eukaryotic Translation Initiation Factor 5A, Longevity: drug effects, Mitochondria, mitochondria, Brain: physiology, Drosophila melanogaster, Cardiovascular and Metabolic Diseases, Dietary Supplements, Mitochondria: metabolism, brain aging, Drosophila, Spermidine: pharmacology, Brain: metabolism, Topic 2: Molecular Processes and Therapies, Research Paper

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40489973
https://pub.dzne.de/record/279519

Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice

Συγγραφείς: Ali Rezaei, Virág Kocsis-Jutka, Zeynep I. Gunes, Qing Zeng, Georg Kislinger, Franz Bauernschmitt, Huseyin Berkcan Isilgan, Laura R. Parisi, Tuğberk Kaya, Sören Franzenburg, Jonas Koppenbrink, Julia Knogler, Thomas Arzberger, Daniel Farny, Brigitte Nuscher, Eszter Katona, Ashutosh Dhingra, Chao Yang, Garyfallia Gouna, Katherine D. LaClair, Aleksandar Janjic, Wolfgang Enard, Qihui Zhou, Nellwyn Hagan, Dimitry Ofengeim, Eduardo Beltrán, Ozgun Gokce, Mikael Simons, Sabine Liebscher, Dieter Edbauer

Πηγή: Nat Commun
Nature Communications, Vol 16, Iss 1, Pp 1-17 (2025)
Nature Communications 16(1), 3442 (2025). doi:10.1038/s41467-025-58634-4

Θεματικοί όροι: C9orf72 Protein: genetics, Male, Amyotrophic Lateral Sclerosis: genetics, Myelin Sheath: metabolism, Science, Longevity, Mice, Transgenic, Article, Mice, Oligodendroglia: metabolism, Spinal Cord: metabolism, 2-Hydroxypropyl-beta-cyclodextrin: pharmacology, Animals, Humans, Myelin Sheath, Lipid Metabolism: drug effects, Lipid Metabolism: genetics, C9orf72 Protein, Amyotrophic Lateral Sclerosis, Longevity: genetics, Amyotrophic Lateral Sclerosis: pathology, Lipid Metabolism, Longevity: drug effects, 2-Hydroxypropyl-beta-cyclodextrin, Oligodendroglia, Disease Models, Animal, Cholesterol, Spinal Cord, Oligodendroglia: drug effects, Amyotrophic Lateral Sclerosis: drug therapy, Cholesterol: metabolism, Amyotrophic Lateral Sclerosis: metabolism, Female, C9orf72 Protein: metabolism, Spinal Cord: pathology

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40216746
https://doaj.org/article/8202e2275a264a0cb71fc18fc336eb86
https://pub.dzne.de/record/277990
https://epub.ub.uni-muenchen.de/126010/

Comprehensive evaluation of lifespan‐extending molecules in C. elegans

Συγγραφείς: Grace B. Phelps, Jonas Morin, Carla Pinto, Lucas Schoenfeldt, Sebastien Guilmot, Alejandro Ocampo, Kevin Perez

Πηγή: Aging Cell
Aging cell, vol. 24, no. 4, pp. e14424

Θεματικοί όροι: Aging, Longevity, Animals, Caenorhabditis elegans/drug effects, Caenorhabditis elegans/physiology, Longevity/drug effects, Caenorhabditis elegans Proteins/metabolism, Caenorhabditis elegans Proteins/genetics, Aging/drug effects, C. elegans, aging, diet, drugs, lifespan, screening, worms, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Research Article

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39853804
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4BE8BAA7C4CC8
https://serval.unil.ch/notice/serval:BIB_4BE8BAA7C4CC
https://serval.unil.ch/resource/serval:BIB_4BE8BAA7C4CC.P001/REF.pdf

Biophoton Communication Between Cells: Faster‑Than‑Chemical Inter‑Cell Signaling in the Energy‑Consciousness Observer Framework (ECOF)

Συγγραφείς: Blatt, Kate Lynn

Συνεισφορές: Blatt, Kate Lynn

Θεματικοί όροι: FOS: Computer and information sciences, Longevity/drug effects, Integrative Oncology/nursing, Regenerative Medicine/methods, Regenerative Medicine/standards, Longevity, biofield dynamics, inter-cellular communication, photonics, Biophysics, Longevity/physiology, Regenerative Medicine, coherence signaling, Biophotons, Health Information Systems, longevity, cancer, Biophysics/methods, Integrative Oncology/instrumentation, energy systems, Cancer, ECOF identity-field logic, Energy distribution system, Oncologists, cancer treatment, Cellular Communication, signal transmission, Systems Biology, Longevity/genetics, Longevity/radiation effects, quantum-informed biological models, Regenerative Medicine/instrumentation, systems biology, Longevity/immunology, ultra-weak photon emission (UPE), quantum biology, cellular biology, developmental morphogenesis, Longevity/ethics, biophysical signaling mechanisms, ECOF (Energy-Consciousness Observer Framework), Information Systems

Biological Foundations of Universal Sexual Transition ; There Is No Menopause/Andropause Later Life as Universal Sexual Transition

Συγγραφείς: Blatt, Kate Lynn

Συνεισφορές: Blatt, Kate Lynn

Θεματικοί όροι: Longevity, Longevity/genetics, Longevity/physiology, Longevity/ethics, Longevity/immunology, Longevity/drug effects, Longevity/radiation effects

Relation: https://zenodo.org/records/17211857; oai:zenodo.org:17211857; https://doi.org/10.5281/zenodo.17211857

Διαθεσιμότητα: https://doi.org/10.5281/zenodo.17211857
https://zenodo.org/records/17211857

Biological Foundations of Universal Sexual Transition

Συγγραφείς: Blatt, Kate Lynn

Συνεισφορές: Blatt, Kate Lynn

Θεματικοί όροι: Longevity, Longevity/genetics, Longevity/physiology, Longevity/ethics, Longevity/immunology, Longevity/drug effects, Longevity/radiation effects

Relation: https://zenodo.org/records/17203222; oai:zenodo.org:17203222; https://doi.org/10.5281/zenodo.17203222

Διαθεσιμότητα: https://doi.org/10.5281/zenodo.17203222
https://zenodo.org/records/17203222

How Women Become Men With Age: Post-Menopausal Hormonal Shift, Androgenic Drift, and Gendered Identity Change in Aging Females

Συγγραφείς: Blatt, Kate Lynn

Συνεισφορές: Blatt, Kate Lynn

Θεματικοί όροι: Longevity, Longevity/genetics, Longevity/physiology, Longevity/ethics, Longevity/immunology, Longevity/drug effects, Longevity/radiation effects, longivity

Relation: https://zenodo.org/records/17186220; oai:zenodo.org:17186220; https://doi.org/10.5281/zenodo.17186220

Διαθεσιμότητα: https://doi.org/10.5281/zenodo.17186220
https://zenodo.org/records/17186220

How Men Become Women With Age Hormonal Decline, Phenotypic Drift, and Gendered Identity Change in the Aging Male

Συγγραφείς: Blatt, Kate Lynn

Συνεισφορές: Blatt, Kate Lynn

Θεματικοί όροι: Longevity, Longevity/genetics, Longevity/physiology, Longevity/ethics, Longevity/immunology, Longevity/drug effects, Longevity/radiation effects

Relation: https://zenodo.org/records/17186121; oai:zenodo.org:17186121; https://doi.org/10.5281/zenodo.17186121

Διαθεσιμότητα: https://doi.org/10.5281/zenodo.17186121
https://zenodo.org/records/17186121

An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo

Συγγραφείς: Lujan, Celia, Tyler, Eleanor Jane, Ecker, Simone, Webster, Amy Philomena, Stead, Eleanor Rachel, Martinez-Miguel, Victoria Eugenia, Milligan, Deborah, Garbe, James Charles, Stampfer, Martha Ruskin, Beck, Stephan, Lowe, Robert, Bishop, Cleo Lucinda, Bjedov, Ivana

Πηγή: http://lobid.org/resources/99370670445306441#!, 16(1):85.

Θεματικοί όροι: Senescence, Rapamycin, Advances in healthy aging and age-related diseases, DNA Methylation/drug effects [MeSH], Humans [MeSH], CpG methylation, Longevity/drug effects [MeSH], Sirolimus/pharmacology [MeSH], Animals [MeSH], CellPopAge epigenetic Clock, Drosophila [MeSH], Drug Evaluation, Preclinical/methods [MeSH], Research, Cellular Senescence/drug effects [MeSH], Drug discovery, Drug Discovery/methods [MeSH], Cells, Cultured [MeSH], Ageing, Epigenesis, Genetic/drug effects [MeSH], Aging/drug effects [MeSH]

Relation: https://repository.publisso.de/resource/frl:6518979; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218148/

Διαθεσιμότητα: https://repository.publisso.de/resource/frl:6518979
https://doi.org/10.1186/s13073-024-01349-w
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11218148/

Taurine deficiency as a driver of aging

Συγγραφείς: Singh, Parminder, Gollapalli, Kishore, Mangiola, Stefano, Schranner, Daniela, Yusuf, Mohd Aslam, Chamoli, Manish, Shi, Sting, Lopes Bastos, Bruno, Nair, Tripti, Riermeier, Annett, Vayndorf, Elena, Wu, Judy, Nilakhe, Aishwarya, Nguyen, Christina, Muir, Michael, Kiflezghi, Michael, Foulger, Anna, Junker, Alex, Devine, Jack, Sharan, Kunal, Chinta, Shankar, Rajput, Swati, Rane, Anand, Baumert, Philipp, Schönfelder, Martin, Iavarone, Francescopaolo, Di Lorenzo, Giorgia, Kumari, Swati, Gupta, Alka, Sarkar, Rajesh, Khyriem, Costerwell, Chawla, Amanpreet, Sharma, Ankur, Sarper, Nazan, Chattopadhyay, Naibedya, Biswal, Bichitra, Settembre, Carmine, Nagarajan, Perumal, Targoff, Kimara, Picard, Martin, Gupta, Sarika, Velagapudi, Vidya, Papenfuss, Anthony, Kaya, Alaattin, Ferreira, Miguel Godinho, Kennedy, Brian, Andersen, Julie, Lithgow, Gordon, Ali, Abdullah Mahmood, Mukhopadhyay, Arnab, Palotie, Aarno, Kastenmüller, Gabi, Kaeberlein, Matt, Wackerhage, Henning, Pal, Bhupinder, Yadav, Vijay

Συνεισφορές: GODINHO FERREIRA, Miguel, Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Research Programs Unit, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, HUS Shared Group Services

Πηγή: Science 380:eabn9257 (2023)
Science, vol 380, iss 6649

Θεματικοί όροι: 2. Zero hunger, Aging, Longevity/drug effects, Taurine/blood, Taurine, Longevity, Neurosciences, Aging/blood, Haplorhini, 3. Good health, [SDV] Life Sciences [q-bio], Telomerase/metabolism, Biomedicine, Mice, name=General, DNA Damage/drug effects, Dietary Supplements, Animals, Humans, Telomerase, Cellular Senescence, DNA Damage

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/37289866
https://hal.science/hal-04134282v1
https://doi.org/10.1126/science.abn9257
https://hdl.handle.net/11588/926103
https://avesis.kocaeli.edu.tr/publication/details/9363aae3-5b4d-4522-8d5b-4be99219c308/oai
http://hdl.handle.net/10138/592116
https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=67841
https://hdl.handle.net/11591/551865
https://doi.org/10.1126/science.abn9257
https://escholarship.org/uc/item/0520x1j5

A multi-tissue full lifespan epigenetic clock for mice

Συγγραφείς: Thompson, Michael J, ChwiaÅ‚kowska, Karolina, Rubbi, Liudmilla, Lusis, Aldons J, Davis, Richard C, Srivastava, Anuj, Korstanje, Ron, Churchill, Gary A, Horvath, Steve, Pellegrini, Matteo

Πηγή: Aging (Albany NY)
Aging, vol 10, iss 10

Θεματικοί όροι: Male, 0301 basic medicine, Aging, Biological clocks - drug effects, knockout, Clinical sciences, Longevity - drug effects, Inbred C57BL, Epigenesis, Genetic, CpG islands, Mice, Longevity - genetics, Databases, Genetic, Medicine and Health Sciences, animal, Inbred BALB C, Mice, Knockout, genetic - drug effects, Mice, Inbred BALB C, DNA methylation, Age Factors, Life Sciences, Biological Sciences, Dna methylation - drug effects, Mutant Strains, mutant strains, Female, Age factors, Research Paper, Genome-wide association study, Knockout, Caloric restriction, Longevity, Dwarfism, Disease models, Databases, 03 medical and health sciences, Genetic, Species Specificity, Biological Clocks, Genetics, inbred C57BL, Animals, Biological clocks - genetics, Dwarfism - metabolism, inbred BALB C, Species specificity, mouse, Caloric Restriction, Sirolimus - pharmacology, Sirolimus, Animal, DNA Methylation, Mice, Mutant Strains, biological age, Mice, Inbred C57BL, Disease Models, Animal, Biochemistry and cell biology, Disease Models, CpG Islands, Generic health relevance, genetic, epigenetic clock, Dwarfism - genetics, Epigenesis, Genome-Wide Association Study

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/30348905
https://s3-us-west-1.amazonaws.com/paperchase-aging/pdf/oDrBDndRinpCMEfbp.pdf
https://doi.org/10.18632/aging.101590
https://escholarship.org/content/qt14v1616q/qt14v1616q.pdf
https://escholarship.org/uc/item/14v1616q

Targeting the Electron Transport System for Enhanced Longevity

Συγγραφείς: Radovic, Marko, Gartzke, Lucas P, Wink, Simon E, van der Kleij, Joris A, Politiek, Frouwkje A, Krenning, Guido

Πηγή: Radovic, M, Gartzke, L P, Wink, S E, van der Kleij, J A, Politiek, F A & Krenning, G 2025, 'Targeting the Electron Transport System for Enhanced Longevity', Biomolecules, vol. 15, no. 5, 614. https://doi.org/10.3390/biom15050614

Θεματικοί όροι: Humans, Longevity/drug effects, Electron Transport/drug effects, Metformin/pharmacology, Animals, Mitochondria/metabolism, Sirolimus/pharmacology, Reactive Oxygen Species/metabolism, Oxidative Phosphorylation/drug effects

Περιγραφή αρχείου: application/pdf

Relation: info:eu-repo/semantics/altIdentifier/pmid/40427507; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/ba16c68f-7ad9-4011-90d6-dde37981aaf8; info:eu-repo/semantics/altIdentifier/pissn/2218-273X; info:eu-repo/semantics/altIdentifier/eissn/2218-273X

Διαθεσιμότητα: https://hdl.handle.net/11370/ba16c68f-7ad9-4011-90d6-dde37981aaf8
https://research.rug.nl/en/publications/ba16c68f-7ad9-4011-90d6-dde37981aaf8
https://doi.org/10.3390/biom15050614
https://pure.rug.nl/ws/files/1326108163/biomolecules-15-00614-v2.pdf

Longevity, aging and rapamycin

Συγγραφείς: Ehninger, Dan, Neff, Frauke, Xie, Kan

Πηγή: Cell Mol Life Sci
Cellular and molecular life sciences 71(22), 4325-4346 (2014). doi:10.1007/s00018-014-1677-1

Θεματικοί όροι: 0301 basic medicine, Aging, Neurons: metabolism, Longevity, Review, Signal Transduction: drug effects, Cellular and Molecular Neuroscience, 03 medical and health sciences, Animals, Humans, Molecular Biology, Neurons: drug effects, Pharmacology, Neurons, Sirolimus, 0303 health sciences, Antibiotics, Antineoplastic, TOR Serine-Threonine Kinases, Cell Biology, Longevity: drug effects, 3. Good health, TOR Serine-Threonine Kinases: metabolism, Gene Expression Regulation, Molecular Medicine, Sirolimus: pharmacology, Antibiotics, Antineoplastic: pharmacology, Gene Expression Regulation: drug effects, Signal Transduction

Σύνδεσμος πρόσβασης: https://link.springer.com/content/pdf/10.1007%2Fs00018-014-1677-1.pdf
https://pubmed.ncbi.nlm.nih.gov/25015322
https://pub.dzne.de/record/137629

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Συγγραφείς: Dongryeol Ryu, Laurent Mouchiroud, Pénélope A Andreux, Elena Katsyuba, Norman Moullan, Amandine A Nicolet-dit-Félix, Evan G Williams, Pooja Jha, Giuseppe Lo Sasso, Damien Huzard, Patrick Aebischer, Carmen Sandi, Chris Rinsch, Johan Auwerx

Πηγή: Nature medicine.-2016
Nature Medicine, 22 (8), 879-88 (2016)

Θεματικοί όροι: 0301 basic medicine, Longevity/drug effects, Fertility/drug effects, Longevity, Mitochondria/drug effects/metabolism, Mitophagy/drug effects, Genetics & genetic processes, DNA, Mitochondrial/drug effects/metabolism, Real-Time Polymerase Chain Reaction, DNA, Mitochondrial, Myoblasts, Génétique & processus génétiques, Mice, 03 medical and health sciences, Oxygen Consumption, Coumarins, Coumarins/pharmacology, Animals, RNA, Messenger, Pharynx/drug effects, Caenorhabditis elegans, Muscle, Skeletal, 2. Zero hunger, 0303 health sciences, Microscopy, Confocal, Myoblasts/drug effects/metabolism, Mitophagy, Life sciences, Mitochondria, Rats, 3. Good health, Fertility, Sciences du vivant, Pharynx, RNA, Messenger/drug effects/metabolism, Muscle, Skeletal/drug effects/metabolism

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/27400265
https://sonar.ch/global/documents/69532
https://orbilu.uni.lu/handle/10993/43153

NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

Συγγραφείς: Zhang, Hongbo, Ryu, Dongryeol, Wu, Yibo, Gariani, Karim, Wang, Xu, Luan, Peiling, D'Amico, Davide, Ropelle, Eduardo R, Lutolf, Matthias P, Aebersold, Ruedi, Schoonjans, Kristina, Menzies, Keir J, Auwerx, Johan

Πηγή: Science (New York, N.Y.).-2016

Θεματικοί όροι: Niacinamide, 0301 basic medicine, Melanocytes/cytology/drug effects/physiology, Myoblasts, Skeletal, Longevity, Niacinamide/analogs & derivatives/metabolism, Pyridinium Compounds, Inbred C57BL, NAD/metabolism/pharmacology, Repressor Proteins/biosynthesis, Muscular Dystrophies, Myoblasts, Mice, 03 medical and health sciences, Neural Stem Cells, Longevity/drug effects/physiology, Prohibitins, Unfolded Protein Response/drug effects, Animals, Mitochondria/drug effects/physiology, Cellular Senescence, 2. Zero hunger, 0303 health sciences, Animal, Inbred mdx, Cellular Reprogramming, NAD, Neural Stem Cells/cytology/drug effects/physiology, Mitochondria, 3. Good health, Mice, Inbred C57BL, Repressor Proteins, Disease Models, Animal, Oxidative Stress, Skeletal/cytology/drug effects/physiology, Cellular Senescence/drug effects/physiology, Disease Models, Mice, Inbred mdx, Unfolded Protein Response, Melanocytes, Muscular Dystrophies/therapy

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://science.sciencemag.org/content/sci/352/6292/1436.full.pdf
https://pubmed.ncbi.nlm.nih.gov/27127236
https://sonar.ch/global/documents/168071

Find drugs that delay many diseases of old age

Συγγραφείς: Bellantuono, I., DeCabo, R., Ehninger, D., Fernandes, A., Howlett, S.E., Müller, R., Potter, P., Tchkonia, T., Trendelenburg, A.-U., Trejo, J.L., Vandenbroucke, R., van Os, R., van Riel, N.A.W.

Πηγή: Nature. 554:293-295

Θεματικοί όροι: 0301 basic medicine, Aging, Longevity/drug effects, Time Factors, Frail Elderly/statistics & numerical data, Frail Elderly, Longevity, SDG 3 – Goede gezondheid en welzijn, Biomarkers, Pharmacological, Alzheimer Disease/epidemiology, Mice, 03 medical and health sciences, Age Distribution, SDG 3 - Good Health and Well-being, Alzheimer Disease, Neoplasms, 80 and over, Diabetes Mellitus, Animals, Humans, Rejuvenation, Aged, Aged, 80 and over, 2. Zero hunger, 0303 health sciences, Rejuvenation/physiology, Animal, Pharmacological, Multimorbidity, 3. Good health, Aging/drug effects, Disease Models, Animal, Chronic Disease/epidemiology, Disease Models, Chronic Disease, Diabetes Mellitus/epidemiology, Neoplasms/epidemiology, Biomarkers

Σύνδεσμος πρόσβασης: https://www.nature.com/magazine-assets/d41586-018-01668-0/d41586-018-01668-0.pdf
https://pubmed.ncbi.nlm.nih.gov/29446384

Rapamycin extends murine lifespan but has limited effects on aging

Συγγραφείς: Neff, F., Flores-Dominguez, D., Ryan, D., Horsch, M., Schroeder, S., Adler, T., Afonso, L., Aguilar-Pimentel, J., Becker, L., Garrett, L., Hans, W., Hettich, M., Holtmeier, R., Hoelter, S., Moreth, K., Prehn, C., Puk, O., Racz, I., Rathkolb, B., Rozman, J., Naton, B., Ordemann, R., Adamski, J., Beckers, J., Bekeredjian, R., Busch, D., Ehninger, G., Graw, J., Hoefler, H., Klingenspor, M., Klopstock, T., Ollert, M., Stypmann, J., Wolf, E., Wurst, W., Zimmer, A., Fuchs, H., Gailus-Durner, V., de Angelis, M., Ehninger, D.

Πηγή: The journal of clinical investigation 123(8), 3272-3291 (2013). doi:10.1172/JCI67674
JOURNAL OF CLINICAL INVESTIGATION

Θεματικοί όροι: Liver Cirrhosis, Male, Liver: drug effects, Aging, Longevity, Drug Evaluation, Preclinical, Immunoglobulins, mTOR protein, mouse, Muscle Strength: drug effects, Liver Cirrhosis: prevention & control, T-Lymphocytes: drug effects, Leukocyte Count, Mice, Oxygen Consumption: drug effects, Oxygen Consumption, Cell Transformation, Neoplastic: drug effects, Maze Learning: drug effects, Animals, Liver: pathology, Aging: drug effects, Muscle Strength, Maze Learning, TOR Serine-Threonine Kinases: antagonists & inhibitors, Sirolimus, Granuloma, T-Lymphocytes: immunology, Platelet Count, Granuloma: prevention & control, TOR Serine-Threonine Kinases, Immunoglobulins: blood, Survival Analysis, Longevity: drug effects, 3. Good health, Psychomotor Performance: drug effects, Mice, Inbred C57BL, Thyroid Gland: pathology, Cell Transformation, Neoplastic, Phenotype, Liver, Thyroid Gland: drug effects, Sirolimus: pharmacology, Psychomotor Performance

Σύνδεσμος πρόσβασης: http://www.jci.org/articles/view/67674/files/pdf
https://pubmed.ncbi.nlm.nih.gov/23863708
https://pub.dzne.de/record/137008
https://hdl.handle.net/11858/00-001M-0000-0015-13F1-9

Nectarine promotes longevity in Drosophila melanogaster

Συγγραφείς: BOYD, Olga, Weng, Peter, Sun, Xiaoping, Alberico, Thomas, Laslo, Mara, Obenland, David M., Kern, Bradley, Zou, Sige

Πηγή: Free Radical Biology and Medicine, 50 (11), 1669-78 (2011)

Θεματικοί όροι: Superoxide Dismutase/genetics/metabolism, 0301 basic medicine, Longevity/drug effects, Mutation/genetics, Motor Activity/drug effects, Longevity, Motor Activity, Biochimie, biophysique & biologie moléculaire, Antioxidants/administration & dosage, Antioxidants, Animals, Genetically Modified, 03 medical and health sciences, Superoxide Dismutase-1, Drosophila melanogaster/physiology, Animals, Oxidative Stress/drug effects/genetics, 2. Zero hunger, Peroxiredoxins/genetics/metabolism, 0303 health sciences, Phosphoenolpyruvate Carboxykinase (ATP)/genetics/metabolism, Plant Extracts, Superoxide Dismutase, Peroxiredoxins, Life sciences, Diet, Plant Extracts/administration & dosage, Oxidative Stress, Drosophila melanogaster, Fertility, Gene Expression Regulation, Fruit, Mutation, Sciences du vivant, Female, Phosphoenolpyruvate Carboxykinase (ATP), Fertility/drug effects/genetics, Biochemistry, biophysics & molecular biology

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc3090488?pdf=render
https://pubmed.ncbi.nlm.nih.gov/21406223
https://orbilu.uni.lu/handle/10993/41444
https://orbilu.uni.lu/bitstream/10993/41444/1/nihms282274.pdf