Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Συγγραφείς: Leuillier, Matthieu, Chelgham, Mustapha, Messaoudi, Hind, Tu, Ly, Ménoret, Severine, Thuillet, Raphaël, Groussard, Déborah, Lillich, Felix, Ottaviani, Mina, Nicol, Lionel, Mulder, Paul, Humbert, Marc, Richard, Vincent, Anegon, Ignacio, Morisseau, Christophe, Proschak, Ewgenij, Guignabert, Christophe, Bellien, Jérémy

Συνεισφορές: KERANDEL-DION, Céline

Πηγή: Compr Physiol

Θεματικοί όροι: Epoxide Hydrolases, Male, phosphatase activity, Hypertension, Pulmonary, Myocytes, Smooth Muscle, soluble epoxide hydrolase, Pulmonary Artery, Rats, SIRT3, [SDV] Life Sciences [q-bio], Rats, Sprague-Dawley, Sirtuin 3, pulmonary hypertension, Animals, Humans, Sirtuins, Cells, Cultured, Research Article

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41652841
https://pmc.ncbi.nlm.nih.gov/articles/PMC12881838/
https://pubmed.ncbi.nlm.nih.gov/41652841/
https://doi.org/10.1002/cph4.70108
https://inserm.hal.science/inserm-05577851v1
https://inserm.hal.science/inserm-05577851v1/document
https://doi.org/10.1002/cph4.70108

Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats

Συγγραφείς: Leuillier, Matthieu, Platel, Valentin, Tu, Ly, Feugray, Guillaume, Thuillet, Raphaël, Groussard, Déborah, Messaoudi, Hind, Ottaviani, Mina, Chelgham, Mustapha, Nicol, Lionel, Mulder, Paul, Humbert, Marc, Richard, Vincent, Morisseau, Christophe, Brunel, Valéry, Duflot, Thomas, Guignabert, Christophe, Bellien, Jérémy

Πηγή: Cells. 12(4)

Θεματικοί όροι: Biomedical and Clinical Sciences, Clinical Sciences, Lung, Cardiovascular, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Rats, Humans, Animals, Hypertension, Pulmonary, Epoxide Hydrolases, Heart, Cells, Cultured, soluble epoxide hydrolase, epoxyeicosatrienoic acids, pulmonary arterial hypertension, right ventricular dysfunction, Biological sciences, Biomedical and clinical sciences

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/23d008kf
https://escholarship.org/content/qt23d008kf/qt23d008kf.pdf

CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury

Συγγραφείς: Leuillier, Matthieu, Duflot, Thomas, Ménoret, Séverine, Messaoudi, Hind, Djerada, Zoubir, Groussard, Déborah, Denis, Raphaël GP, Chevalier, Laurence, Karoui, Ahmed, Panthu, Baptiste, Thiébaut, Pierre-Alain, Schmitz-Afonso, Isabelle, Nobis, Séverine, Campart, Cynthia, Henry, Tiphaine, Sautreuil, Camille, Luquet, Serge H, Beseme, Olivia, Féliu, Catherine, Peyret, Hélène, Nicol, Lionel, Henry, Jean-Paul, Renet, Sylvanie, Mulder, Paul, Wan, Debin, Tesson, Laurent, Heslan, Jean-Marie, Duché, Angéline, Jacques, Sébastien, Ziegler, Frédéric, Brunel, Valéry, Rautureau, Gilles JP, Monteil, Christelle, do Rego, Jean-Luc, do Rego, Jean-Claude, Afonso, Carlos, Hammock, Bruce, Madec, Anne-Marie, Pinet, Florence, Richard, Vincent, Anegon, Ignacio, Guignabert, Christophe, Morisseau, Christophe, Bellien, Jérémy

Πηγή: Journal of Advanced Research. 43

Θεματικοί όροι: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Nutrition (rcdc), Cardiovascular (rcdc), Genetics (rcdc), Obesity (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), Cardiovascular (hrcs-hc), Metabolic and endocrine (hrcs-hc), Animals (mesh), Female (mesh), Male (mesh), Rats (mesh), CRISPR-Cas Systems (mesh), Epoxide Hydrolases (mesh), Heart Diseases (mesh), Heart Injuries (mesh), Insulin Resistance (mesh), Lysophospholipids (mesh), Obesity (mesh), Phosphoric Monoester Hydrolases (mesh), Reperfusion Injury (mesh), Soluble epoxide hydrolase, Lipid phosphatase, CRISPR-Cas9, Thermogenesis, Obesity, Cardiac ischemic injury, Animals (mesh), Rats (mesh), Heart Diseases (mesh), Reperfusion Injury (mesh), Insulin Resistance (mesh), Obesity (mesh), Heart Injuries (mesh), Epoxide Hydrolases (mesh), Phosphoric Monoester Hydrolases (mesh), Lysophospholipids (mesh), Female (mesh), Male (mesh), CRISPR-Cas Systems (mesh), CRISPR-Cas9, Cardiac ischemic injury, Lipid phosphatase, Obesity, Soluble epoxide hydrolase, Thermogenesis, Animals (mesh), Female (mesh), Male (mesh), Rats (mesh), CRISPR-Cas Systems (mesh), Epoxide Hydrolases (mesh), Heart Diseases (mesh), Heart Injuries (mesh), Insulin Resistance (mesh), Lysophospholipids (mesh), Obesity (mesh), Phosphoric Monoester Hydrolases (mesh), Reperfusion Injury (mesh)

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/1qj4r9ns
https://escholarship.org/content/qt1qj4r9ns/qt1qj4r9ns.pdf

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain

Συγγραφείς: Kramer, Jan S.^aff1, Woltersdorf, Stefano^aff1, Duflot, Thomas^{aff2, aff6}, Hiesinger, Kerstin^aff1, Lillich, Felix F.^aff1, Knöll, Felix^aff1, Wittmann, Sandra K.^aff1, Klingler, Franca-M.^aff1, Brunst, Steffen^aff1, Chaikuad, Apirat^{aff1, aff3}, Morisseau, Christophe^aff4, Hammock, Bruce D.^aff4, Buccellati, Carola^aff5, Sala, Angelo^aff5, Rovati, G. Enrico^aff5, Leuillier, Matthieu^aff6, Fraineau, Sylvain^aff6, Rondeaux, Julie^aff6, Hernandez-Olmos, Victor^{aff1, aff7}, Heering, Jan^{aff1, aff7}, Merk, Daniel^aff1, Pogoryelov, Denys^aff8, Steinhilber, Dieter^aff1, Knapp, Stefan^{aff1, aff2}, Bellien, Jeremy^{aff6, aff9}, Proschak, Ewgenij^aff1

Πηγή: Journal of Medicinal Chemistry. 62(18):8443-8460

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00445

Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients

Συγγραφείς: Duflot, Thomas, Moreau-Grangé, Lucile, Roche, Clothilde, Iacob, Michèle, Wils, Julien, Rémy-Jouet, Isabelle, Cailleux, Anne-Françoise, Leuillier, Matthieu, Renet, Sylvanie, Li, Dongyang, Morisseau, Christophe, Lamoureux, Fabien, Richard, Vincent, Prévost, Gaëtan, Joannidès, Robinson, Bellien, Jérémy

Πηγή: Cardiovascular Diabetology. 18(1)

Θεματικοί όροι: 32 Biomedical and Clinical Sciences (for-2020), 3202 Clinical Sciences (for-2020), Cardiovascular (rcdc), Clinical Research (rcdc), Diabetes (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), Cardiovascular (hrcs-hc), Metabolic and endocrine (hrcs-hc), Aged (mesh), Biomarkers (mesh), Case-Control Studies (mesh), Diabetes Mellitus, Type 2 (mesh), Diabetic Angiopathies (mesh), Eicosanoids (mesh), Epoxide Hydrolases (mesh), Essential Hypertension (mesh), Female (mesh), Humans (mesh), Hyperthermia, Induced (mesh), Male (mesh), Middle Aged (mesh), Nitric Oxide (mesh), Nitrites (mesh), Nitroglycerin (mesh), Radial Artery (mesh), Vasodilation (mesh), Vasodilator Agents (mesh), Type 2 diabetes, Endothelial dysfunction, Soluble epoxide hydrolase, Epoxyeicosatrienoic acids, Radial Artery (mesh), Humans (mesh), Diabetic Angiopathies (mesh), Diabetes Mellitus, Type 2 (mesh), Nitrites (mesh), Nitric Oxide (mesh), Nitroglycerin (mesh), Epoxide Hydrolases (mesh), Eicosanoids (mesh), Vasodilator Agents (mesh), Hyperthermia, Induced (mesh), Case-Control Studies (mesh), Vasodilation (mesh), Aged (mesh), Middle Aged (mesh), Female (mesh), Male (mesh), Biomarkers (mesh), Essential Hypertension (mesh), Endothelial dysfunction, Epoxyeicosatrienoic acids, Soluble epoxide hydrolase, Type 2 diabetes, Aged (mesh), Biomarkers (mesh), Case-Control Studies (mesh), Diabetes Mellitus, Type 2 (mesh), Diabetic Angiopathies (mesh), Eicosanoids (mesh), Epoxide Hydrolases (mesh), Essential Hypertension (mesh), Female (mesh), Humans (mesh), Hyperthermia, Induced (mesh), Male (mesh), Middle Aged (mesh), Nitric Oxide (mesh), Nitrites (mesh), Nitroglycerin (mesh), Radial Artery (mesh), Vasodilation (mesh), Vasodilator Agents (mesh), 1102 Cardiorespiratory Medicine and Haematology (for), Cardiovascular System & Hematology (science-metrix), 3201 Cardiovascular medicine and haematology (for-2020)

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/7tq502bx
https://escholarship.org/content/qt7tq502bx/qt7tq502bx.pdf

Expression of placental CD146 is dysregulated by prenatal alcohol exposure and contributes in cortical vasculature development and positioning of vessel-associated oligodendrocytes

Συγγραφείς: Sautreuil, Camille, Lecointre, Maryline, Dalmasso, Jessica, Lebon, Alexis, Leuillier, Matthieu, Janin, François, Lecuyer, Matthieu, Bekri, Soumeya, Marret, Stéphane, Laquerrière, Annie, Brasse-Lagnel, Carole, Gil, Sophie, Gonzalez, Bruno J.

Πηγή: Frontiers in Cellular Neuroscience ; volume 17 ; ISSN 1662-5102

Διαθεσιμότητα: https://doi.org/10.3389/fncel.2023.1294746
https://www.frontiersin.org/articles/10.3389/fncel.2023.1294746/full

Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?

Συγγραφείς: Duflot, Thomas, Tu, Ly, Leuillier, Matthieu, Messaoudi, Hind, Groussard, Déborah, Feugray, Guillaume, Azhar, Saïda, Thuillet, Raphaël, Bauer, Fabrice, Humbert, Marc, Richard, Vincent, Guignabert, Christophe, Bellien, Jérémy

Συνεισφορές: Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Rouen, Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Université Paris-Saclay, Hôpital Marie-Lannelongue, Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, TargEDys Rouen, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), ANR-16-CE17-0012,SAPHIR,Impact de la modulation des activités enzymatiques de l'époxyde hydrolase soluble sur l'hypertension pulmonaire et la dysfonction ventriculaire droite lors de l'insuffisance cardiaque expérimentale et humaine(2016)

Πηγή: ISSN: 2218-1989 ; Metabolites ; https://hal.science/hal-04532610 ; Metabolites, 2021, 11 (11), pp.784. ⟨10.3390/metabo11110784⟩.

Θεματικοί όροι: [SDV]Life Sciences [q-bio]

Διαθεσιμότητα: https://hal.science/hal-04532610
https://hal.science/hal-04532610v1/document
https://hal.science/hal-04532610v1/file/metabolites-11-00784.pdf
https://doi.org/10.3390/metabo11110784

Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice

Συγγραφείς: Chollat, Clément, Lecointre, Maryline, Leuillier, Matthieu, Remy-Jouet, Isabelle, Do Rego, Jean-Claude, Abily-Donval, Lénaïg, Ramdani, Yasmina, Richard, Vincent, Compagnon, Patricia, Dureuil, Bertrand, Marret, Stéphane, Gonzalez, Bruno José, Jégou, Sylvie, Tourrel, Fabien

Συνεισφορές: Université de Rouen, Institut National de la Santé et de la Recherche Médicale, European Regional Development Fund, Conseil Régional de Haute Normandie

Πηγή: Frontiers in Neurology ; volume 10 ; ISSN 1664-2295

Διαθεσιμότητα: https://doi.org/10.3389/fneur.2019.00407
https://www.frontiersin.org/article/10.3389/fneur.2019.00407/full

MOESM1 of Altered bioavailability of epoxyeicosatrienoic acids is associated with conduit artery endothelial dysfunction in type 2 diabetic patients

Συγγραφείς: Duflot, Thomas, Moreau-Grangé, Lucile, Roche, Clothilde, Iacob, Michèle, Wils, Julien, Rémy-Jouet, Isabelle, Cailleux, Anne-Françoise, Leuillier, Matthieu, Renet, Sylvanie, Li, Dongyang, Morisseau, Christophe, Lamoureux, Fabien, Richard, Vincent, Prévost, Gaëtan, Joannidès, Robinson, Bellien, Jérémy

Θεματικοί όροι: 3. Good health

Multiple and Opposite Effects of Angiotensin II Receptor Blockers on the Bioavailability of Epoxyeicosatrienoic Acids

Συγγραφείς: Bellien, Jeremy, Leuillier, Matthieu, Louhichi, Safa, Duflot, Thomas, Joannides, Robinson

Πηγή: Basic & Clinical Pharmacology & Toxicology ; volume 121, issue 4, page 213-214 ; ISSN 1742-7835 1742-7843

Διαθεσιμότητα: http://dx.doi.org/10.1111/bcpt.12810
https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbcpt.12810
https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcpt.12810

Lysophospholipids, Lysophosphatidic Acids and Monoacylglycerols: New Therapeutic Targets in Cardiovascular Diseases?

Συγγραφείς: Duflot, Thomas, primary, Tu, Ly, additional, Leuillier, Matthieu, additional, Messaoudi, Hind, additional, Groussard, Déborah, additional, Azhar, Saïda, additional, Thuillet, Raphaël, additional, Humbert, Marc, additional, Richard, Vincent, additional, Guignabert, Christophe, additional, Bellien, Jérémy, additional

Πηγή: 2021/09/03

Σύνδεσμος πρόσβασης: https://www.preprints.org/manuscript/202109.0071/v1/download

Role of the phosphatase activity of soluble epoxide hydrolase in the regulation of metabolic and cardiovascular homeostasis ; Rôle de l'activité phosphatase de l'époxyde hydrolase soluble dans la régulation de l'homéostasie métabolique et cardiovasculaire.

Συγγραφείς: Leuillier, Matthieu

Συνεισφορές: Nouvelles Cibles Pharmacologiques de la Protection Endothéliale et de l'Insuffisance Cardiaque (EnVI), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université, Jérémy Bellien

Πηγή: https://theses.hal.science/tel-04841981 ; Cardiologie et système cardiovasculaire. Normandie Université, 2019. Français. ⟨NNT : 2019NORMR150⟩.

Θεματικοί όροι: Cardiometabolic homeostasis, Cardiovascular homeostasis, Metabolic homeostasis, Soluble epoxide hydrolase, Homéostasie cardiométabolique, Homéostasie cardiovasculaire, Homéostasie métabolique, Epoxyde hydrolase soluble, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system

Relation: NNT: 2019NORMR150

Διαθεσιμότητα: https://theses.hal.science/tel-04841981
https://theses.hal.science/tel-04841981v1/document
https://theses.hal.science/tel-04841981v1/file/matthieuleuillier.pdf
https://doi.org/10.70675/5b0c2a46zee6az4508z9e51zb46f12261b45

Rôle de l'activité phosphatase de l'époxyde hydrolase soluble dans la régulation de l'homéostasie métabolique et cardiovasculaire. ; Role of the phosphatase activity of soluble epoxide hydrolase in the regulation of metabolic and cardiovascular homeostasis

Συγγραφείς: Leuillier, Matthieu

Συνεισφορές: Normandie, Bellien, Jérémy

Θεματικοί όροι: Epoxyde hydrolase soluble, Homéostasie métabolique, Homéostasie cardiovasculaire, Homéostasie cardiométabolique, Soluble epoxide hydrolase, Metabolic homeostasis, Cardiovascular homeostasis, Cardiometabolic homeostasis, 616.1

Relation: http://www.theses.fr/2019NORMR150/document

Διαθεσιμότητα: http://www.theses.fr/2019NORMR150/document

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.

Συγγραφείς: Kramer, Jan S, Woltersdorf, Stefano, Duflot, Thomas, Hiesinger, Kerstin, Lillich, Felix F, Knöll, Felix, Wittmann, Sandra K, Klingler, Franca-M, Brunst, Steffen, Chaikuad, Apirat, Morisseau, Christophe, Hammock, Bruce D, Buccellati, Carola, Sala, Angelo, Rovati, G Enrico, Leuillier, Matthieu, Fraineau, Sylvain, Rondeaux, Julie, Hernandez-Olmos, Victor, Heering, Jan, Merk, Daniel, Pogoryelov, Denys, Steinhilber, Dieter, Knapp, Stefan, Bellien, Jeremy, Proschak, Ewgenij, Kramer, Jan S

Πηγή: Journal of medicinal chemistry; vol 62, iss 18, 8443-8460; 0022-2623

Όροι ευρετηρίου: Animals, Humans, Rats, Sprague-Dawley, Oxazoles, Epoxide Hydrolases, Phosphoric Monoester Hydrolases, Enzyme Inhibitors, Ligands, Temperature, Binding Sites, Catalytic Domain, Structure-Activity Relationship, Drug Design, Male, Medicinal and Biomolecular Chemistry, Organic Chemistry, Pharmacology and Pharmaceutical Sciences, Medicinal & Biomolecular Chemistry, article

Σύνδεσμος: https://escholarship.org/uc/item/6916568j
https://escholarship.org/

Opposite Roles of the Soluble Epoxide Hydrolase Domains in the Development of Vascular Calcification

Συγγραφείς: Varennes, Olivier, Mentaverri, Romuald, Duflot, Thomas, Objois, Thibaut, Lenglet, Gaëlle, Avondo, Carine, Morisseau, Christophe, Kauffenstein, Gilles, Hamzaoui, Mouad, Leuillier, Matthieu, Brazier, Michel, Kamel, Saïd, Six, Isabelle, Bellien, Jeremy

Συνεισφορές: Biologie des Plantes et Innovation - UR UPJV 3900 (BIOPI), Université de Picardie Jules Verne (UPJV), Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Entomology, School of Medicine-University of California (UC), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Rouen, Normandie Université (NU), Service de Pharmacologie CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN)

Πηγή: ISSN: 0009-7322.

Θεματικοί όροι: [SDV]Life Sciences [q-bio]

Διαθεσιμότητα: https://u-picardie.hal.science/hal-03564974
https://doi.org/10.1161/circ.136.suppl_1.18400