Variational autoencoder-based model improves polygenic prediction in blood cell traits

Συγγραφείς: Xiaoqi Li, Elena Kharitonova, Minxing Pang, Jia Wen, Laura Y. Zhou, Laura Raffield, Haibo Zhou, Huaxiu Yao, Can Chen, Yun Li, Quan Sun

Πηγή: HGG Advances, Vol 6, Iss 4, Pp 100490- (2025)

Θεματικοί όροι: polygenic risk scores, genetics, genetic interations, personalized medicine, deep learning, variational autoencoder, Genetics, QH426-470

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666247725000934; https://doaj.org/toc/2666-2477

Σύνδεσμος πρόσβασης: https://doaj.org/article/ac5555f7df01457a88aea517b81cd4a3

Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations

Συγγραφείς: Michael Elgart, Genevieve Lyons, Santiago Romero-Brufau, Nuzulul Kurniansyah, Jennifer A. Brody, Xiuqing Guo, Henry J. Lin, Laura Raffield, Yan Gao, Han Chen, Paul de Vries, Donald M. Lloyd-Jones, Leslie A. Lange, Gina M. Peloso, Myriam Fornage, Jerome I. Rotter, Stephen S. Rich, Alanna C. Morrison, Bruce M. Psaty, Daniel Levy, Susan Redline, the NHLBI’s Trans-Omics in Precision Medicine (TOPMed) Consortium, Tamar Sofer

Πηγή: Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)

Θεματικοί όροι: Biology (General), QH301-705.5

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2399-3642

Σύνδεσμος πρόσβασης: https://doaj.org/article/d5b943dc87ee467e87670ec528cf6ef7

Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthmaResearch in context

Συγγραφείς: Kathryn Recto, Priyadarshini Kachroo, Tianxiao Huan, David Van Den Berg, Gha Young Lee, Helena Bui, Dong Heon Lee, Jessica Gereige, Chen Yao, Shih-Jen Hwang, Roby Joehanes, Scott T. Weiss, George T. O’Connor, Daniel Levy, Dawn L. DeMeo, Namiko Abe, Gonçalo Abecasis, Francois Aguet, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Kristin Ardlie, Dan Arking, Donna K. Arnett, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, Najib Ayas, Adithya Balasubramanian, John Barnard, Kathleen Barnes, R. Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Rebecca Beer, Amber Beitelshees, Emelia Benjamin, Takis Benos, Marcos Bezerra, Larry Bielak, Joshua Bis, Thomas Blackwell, John Blangero, Nathan Blue, Eric Boerwinkle, Donald W. Bowden, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Jai Broome, Deborah Brown, Karen Bunting, Esteban Burchard, Carlos Bustamante, Erin Buth, Brian Cade, Jonathan Cardwell, Vincent Carey, Julie Carrier, April P. Carson, Cara Carty, Richard Casaburi, Juan P. Casas Romero, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Yii-Der Ida Chen, Michael Cho, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Adolfo Correa, Carolyn Crandall, James Crapo, L. Adrienne Cupples, Joanne Curran, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Sean David, Colleen Davis, Michelle Daya, Mariza de Andrade, Lisa de las Fuentes, Paul de Vries, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Huyen Dinh, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Ravi Duggirala, Jon Peter Durda, Susan K. Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Patrick Ellinor, Leslie Emery, Serpil Erzurum, Charles Farber, Jesse Farek, Tasha Fingerlin, Matthew Flickinger, Myriam Fornage, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Yan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Stephanie Gogarten, Da-Wei Gong, Harald Goring, Sharon Graw, Kathryn J. Gray, Daniel Grine, Colin Gross, C. Charles Gu, Yue Guan, Xiuqing Guo, Namrata Gupta, Jeff Haessler, Michael Hall, Yi Han, Patrick Hanly, Daniel Harris, Nicola L. Hawley, Jiang He, Ben Heavner, Susan Heckbert, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, John Hokanson, Elliott Hong, Karin Hoth, Chao (Agnes) Hsiung, Jianhong Hu, Yi-Jen Hung, Haley Huston, Chii Min Hwu, Marguerite Ryan Irvin, Rebecca Jackson, Deepti Jain, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Robert Kaplan, Sharon Kardia, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Ziad Khan, Wonji Kim, John Kimoff, Greg Kinney, Barbara Konkle, Charles Kooperberg, Holly Kramer, Christoph Lange, Ethan Lange, Leslie Lange, Cathy Laurie, Cecelia Laurie, Meryl LeBoff, Jiwon Lee, Sandra Lee, Wen-Jane Lee, Jonathon LeFaive, David Levine, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Xihong Lin, Simin Liu, Yongmei Liu, Yu Liu, Ruth J.F. Loos, Steven Lubitz, Kathryn Lunetta, James Luo, Ulysses Magalang, Michael Mahaney, Barry Make, Ani Manichaikul, Alisa Manning, JoAnn Manson, Lisa Martin, Melissa Marton, Susan Mathai, Rasika Mathias, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Stephen McGarvey, Daniel McGoldrick, Caitlin McHugh, Becky McNeil, Hao Mei, James Meigs, Vipin Menon, Luisa Mestroni, Ginger Metcalf, Deborah A. Meyers, Emmanuel Mignot, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L. Minster, Braxton D. Mitchell, Matt Moll, Zeineen Momin, May E. Montasser, Courtney Montgomery, Donna Muzny, Josyf C. Mychaleckyj, Girish Nadkarni, Rakhi Naik, Take Naseri, Pradeep Natarajan, Sergei Nekhai, Sarah C. Nelson, Bonnie Neltner, Caitlin Nessner, Deborah Nickerson, Osuji Nkechinyere, Kari North, Jeff O'Connell, Tim O'Connor, Heather Ochs-Balcom, Geoffrey Okwuonu, Allan Pack, David T. Paik, Nicholette Palmer, James Pankow, George Papanicolaou, Cora Parker, Gina Peloso, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S. Phillips, Jacob Pleiness, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Bruce Psaty, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Laura Raffield, Mahitha Rajendran, Vasan S. Ramachandran, D.C. Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Susan Redline, Robert Reed, Catherine Reeves, Elizabeth Regan, Alex Reiner, Muagututi‘a Sefuiva Reupena, Ken Rice, Stephen Rich, Rebecca Robillard, Nicolas Robine, Dan Roden, Carolina Roselli, Jerome Rotter, Ingo Ruczinski, Alexi Runnels, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Sejal Salvi, Steven Salzberg, Kevin Sandow, Vijay G. Sankaran, Jireh Santibanez, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Frédéric Sériès, Vivien Sheehan, Stephanie L. Sherman, Amol Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, M. Benjamin Shoemaker, Brian Silver, Edwin Silverman, Robert Skomro, Albert Vernon Smith, Jennifer Smith, Josh Smith, Nicholas Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Nona Sotoodehnia, Adrienne M. Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Daniel Taliun, Hua Tang, Margaret Taub, Kent Taylor, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A. Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Russell Tracy, Michael Tsai, Dhananjay Vaidya, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Fei Fei Wang, Heming Wang, Jiongming Wang, Karol Watson, Jennifer Watt, Daniel E. Weeks, Joshua Weinstock, Bruce Weir, Lu-Chen Weng, Jennifer Wessel, Cristen Willer, Kayleen Williams, L. Keoki Williams, Scott Williams, Carla Wilson, James Wilson, Lara Winterkorn, Quenna Wong, Baojun Wu, Joseph Wu, Huichun Xu, Lisa Yanek, Ivana Yang, Ketian Yu, Seyedeh Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Xiaofeng Zhu, Elad Ziv, Michael Zody, Sebastian Zoellner

Πηγή: EBioMedicine, Vol 95, Iss , Pp 104758- (2023)

Θεματικοί όροι: EWAS, DNA methylation, IgE, Asthma, RNA-Sequencing, Mendelian randomization, Medicine, Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423003237; https://doaj.org/toc/2352-3964

Σύνδεσμος πρόσβασης: https://doaj.org/article/27216a63c1a4464a8d8e43ae3d837982

CUE: CpG impUtation ensemble for DNA methylation levels across the human methylation450 (HM450) and EPIC (HM850) BeadChip platforms

Συγγραφείς: Gang Li, Laura Raffield, Mark Logue, Mark W. Miller, Hudson P. Santos, T. Michael O’Shea, Rebecca C. Fry, Yun Li

Πηγή: Epigenetics, Vol 16, Iss 8, Pp 851-861 (2021)

Θεματικοί όροι: dna methylation, imputation, ensemble learning, hm450, hm850, placenta, whole blood, Genetics, QH426-470

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Σύνδεσμος πρόσβασης: https://doaj.org/article/39ba754f5ec74554a1e661da4f0001ba

Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

Συγγραφείς: Charles E. Breeze, Anna Batorsky, Mi Kyeong Lee, Mindy D. Szeto, Xiaoguang Xu, Daniel L. McCartney, Rong Jiang, Amit Patki, Holly J. Kramer, James M. Eales, Laura Raffield, Leslie Lange, Ethan Lange, Peter Durda, Yongmei Liu, Russ P. Tracy, David Van Den Berg, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed MESA Multi-Omics Working Group, Kathryn L. Evans, William E. Kraus, Svati Shah, Hermant K. Tiwari, Lifang Hou, Eric A. Whitsel, Xiao Jiang, Fadi J. Charchar, Andrea A. Baccarelli, Stephen S. Rich, Andrew P. Morris, Marguerite R. Irvin, Donna K. Arnett, Elizabeth R. Hauser, Jerome I. Rotter, Adolfo Correa, Caroline Hayward, Steve Horvath, Riccardo E. Marioni, Maciej Tomaszewski, Stephan Beck, Sonja I. Berndt, Stephanie J. London, Josyf C. Mychaleckyj, Nora Franceschini

Πηγή: Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)

Θεματικοί όροι: Epigenetic, Kidney function, Gene regulation, Kidney development, DNA methylation, Medicine, Genetics, QH426-470

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1756-994X

Σύνδεσμος πρόσβασης: https://doaj.org/article/357ae5d7998e4adaaf16337fd7e2f26e

Incorporating polygenic risk scores and social determinants of health across populations: Considerations and best practices in research

Συγγραφείς: Sara J. Cromer, Ewan K. Cobran, Hari S. Iyer, Micah R. Hysong, Luciana B. Vargas, Johanna L. Smith, Iain R. Konigsberg, David Bogumil, LáShauntá Glover, Gillian King, Leslie A. Lange, Aniruddh Patel, Genevieve Wojcik, Laura Raffield, David V. Conti

Πηγή: Am J Hum Genet

Θεματικοί όροι: Article

Σύνδεσμος πρόσβασης: https://pmc.ncbi.nlm.nih.gov/articles/PMC12981347/
https://doi.org/10.1016/j.ajhg.2026.02.007
https://pubmed.ncbi.nlm.nih.gov/41785862/

Genetic discovery and risk characterization in type 2 diabetes across diverse populations

Συγγραφείς: Linda M. Polfus, Burcu F. Darst, Heather Highland, Xin Sheng, Maggie C.Y. Ng, Jennifer E. Below, Lauren Petty, Stephanie Bien, Xueling Sim, Wei Wang, Pierre Fontanillas, Yesha Patel, Michael Preuss, Claudia Schurmann, Zhaohui Du, Yingchang Lu, Suhn K. Rhie, Joseph M. Mercader, Teresa Tusie-Luna, Clicerio González-Villalpando, Lorena Orozco, Cassandra N. Spracklen, Brian E. Cade, Richard A. Jensen, Meng Sun, Yoonjung Yoonie Joo, Ping An, Lisa R. Yanek, Lawrence F. Bielak, Salman Tajuddin, Aude Nicolas, Guanjie Chen, Laura Raffield, Xiuqing Guo, Wei-Min Chen, Girish N. Nadkarni, Mariaelisa Graff, Ran Tao, James S. Pankow, Martha Daviglus, Qibin Qi, Eric A. Boerwinkle, Simin Liu, Lawrence S. Phillips, Ulrike Peters, Chris Carlson, Lynne R. Wikens, Loic Le Marchand, Kari E. North, Steven Buyske, Charles Kooperberg, Ruth J.F. Loos, Daniel O. Stram, Christopher A. Haiman

Πηγή: HGG Advances, Vol 2, Iss 2, Pp 100029- (2021)

Θεματικοί όροι: Type 2 Diabetes, Genetic Risk Score, Genetics, QH426-470

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666247721000105; https://doaj.org/toc/2666-2477

Σύνδεσμος πρόσβασης: https://doaj.org/article/dbef0a520b5d4bda84a828de1df9808d

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Συγγραφείς: Peter K. Joshi, Nicola Pirastu, Katherine A. Kentistou, Krista Fischer, Edith Hofer, Katharina E. Schraut, David W. Clark, Teresa Nutile, Catriona L. K. Barnes, Paul R. H. J. Timmers, Xia Shen, Ilaria Gandin, Aaron F. McDaid, Thomas Folkmann Hansen, Scott D. Gordon, Franco Giulianini, Thibaud S. Boutin, Abdel Abdellaoui, Wei Zhao, Carolina Medina-Gomez, Traci M. Bartz, Stella Trompet, Leslie A. Lange, Laura Raffield, Ashley van der Spek, Tessel E. Galesloot, Petroula Proitsi, Lisa R. Yanek, Lawrence F. Bielak, Antony Payton, Federico Murgia, Maria Pina Concas, Ginevra Biino, Salman M. Tajuddin, Ilkka Seppälä, Najaf Amin, Eric Boerwinkle, Anders D. Børglum, Archie Campbell, Ellen W. Demerath, Ilja Demuth, Jessica D. Faul, Ian Ford, Alessandro Gialluisi, Martin Gögele, MariaElisa Graff, Aroon Hingorani, Jouke-Jan Hottenga, David M. Hougaard, Mikko A. Hurme, M. Arfan Ikram, Marja Jylhä, Diana Kuh, Lannie Ligthart, Christina M. Lill, Ulman Lindenberger, Thomas Lumley, Reedik Mägi, Pedro Marques-Vidal, Sarah E. Medland, Lili Milani, Reka Nagy, William E. R. Ollier, Patricia A. Peyser, Peter P. Pramstaller, Paul M. Ridker, Fernando Rivadeneira, Daniela Ruggiero, Yasaman Saba, Reinhold Schmidt, Helena Schmidt, P. Eline Slagboom, Blair H. Smith, Jennifer A. Smith, Nona Sotoodehnia, Elisabeth Steinhagen-Thiessen, Frank J. A. van Rooij, André L. Verbeek, Sita H. Vermeulen, Peter Vollenweider, Yunpeng Wang, Thomas Werge, John B. Whitfield, Alan B. Zonderman, Terho Lehtimäki, Michele K. Evans, Mario Pirastu, Christian Fuchsberger, Lars Bertram, Neil Pendleton, Sharon L. R. Kardia, Marina Ciullo, Diane M. Becker, Andrew Wong, Bruce M. Psaty, Cornelia M. van Duijn, James G. Wilson, J. Wouter Jukema, Lambertus Kiemeney, André G. Uitterlinden, Nora Franceschini, Kari E. North, David R. Weir, Andres Metspalu, Dorret I. Boomsma, Caroline Hayward, Daniel Chasman, Nicholas G. Martin, Naveed Sattar, Harry Campbell, Tōnu Esko, Zoltán Kutalik, James F. Wilson

Πηγή: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Θεματικοί όροι: Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2041-1723

Σύνδεσμος πρόσβασης: https://doaj.org/article/71f6e3ed3cbf4216a67afc3e8eda8b11

Data sharing in the PRIMED Consortium: Design, implementation, and recommendations for future policymaking

Συγγραφείς: Johanna L. Smith, Quenna Wong, Whitney Hornsby, Matthew P. Conomos, Benjamin D. Heavner, Iftikhar J. Kullo, Bruce M. Psaty, Stephen S. Rich, Adrienne M. Stilp, Bamidele Tayo, Yuji Zhang, Pradeep Natarajan, Sarah C. Nelson, Sally Adebamowo, Meliksah Arslan, Ben Heavner, Charles Kooperberg, Matt Kosel, Iftikhar Kullo, Leslie Lange, Yingchang Lu, Alisa Manning, Karlijn Meeks, Tyne Miller-Fleming, Aniruddh Patel, Laura Raffield, Stephen Rich, Xueling Sim, Johanna Smith, Buu Truong, Lisa Wang, Lisa Yanek

Πηγή: Am J Hum Genet

Θεματικοί όροι: Multifactorial Inheritance, Information Dissemination, FOS: Biological sciences, Perspective, Databases, Genetic, Humans, Genomics, Policy Making, Other Quantitative Biology (q-bio.OT), Quantitative Biology - Other Quantitative Biology, United States, Genome-Wide Association Study

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40628271
https://pmc.ncbi.nlm.nih.gov/articles/PMC12414661/
https://pubmed.ncbi.nlm.nih.gov/40628271/
https://doi.org/10.1016/j.ajhg.2025.06.004
http://arxiv.org/abs/2502.09351

Abstract 01: An Atlas of Circulating Metabolites Associated with Incident Coronary Heart Disease in ~23,000 Racially and Ethnically Diverse Adults

Συγγραφείς: Kai Luo, Taryn Alkis, Eun Hye Moon, Huan Yun, Jie Hu, Yulu ZHENG, Christie Ballantyne, Eric Boerwinkle, Clary Clish, Robert Gerszten, Megan Grove, Lifang Hou, F Hu, Scott Hutton, ROBERT KAPLAN, Rozenn Lemaitre, Jun Li, Donald Lloyd-Jones, Matthew Nayor, Kari North, Bruce Psaty, Laura Raffield, Kathryn Rexrode, Stephen Rich, Usman Tahir, Kari Wong, Vanessa Xanthakis, Danxia Yu, Jerome Rotter, Qibin Qi, Bing Yu

Πηγή: Circulation. 153

Abstract MPWE44: A multi-ancestry blood metabolites atlas of incident stroke in ~39,000 adults

Συγγραφείς: Kai Luo, Taryn Alkis, Eun Hye Moon, Christie Ballantyne, Eric Boerwinkle, Clary Clish, Robert Gerszten, Megan Grove, Lifang Hou, Scott Hutton, Chengyong Jia, ROBERT KAPLAN, Rozenn Lemaitre, Donald Lloyd-Jones, Matthew Nayor, Kari North, Bruce Psaty, Laura Raffield, Stephen Rich, Jerome Rotter, Usman Tahir, Tao Wang, Kari Wong, Vanessa Xanthakis, Qibin Qi, Bing Yu

Πηγή: Circulation. 153

Abstract MPWE43: Multi-trait Polygenic Risk Scores Improve Prediction of Heart Failure

Συγγραφείς: Shinhye Chung, Brian Spitzer, Qin Hui, Ngoc Quynh Nguyen, Taryn Alkis, Chang Liu, Traci Bartz, Eric Boerwinkle, Jennifer Brody, Susan Cheng, Myriam Fornage, Michael Hall, Bertha Hidalgo, ROBERT KAPLAN, Donald Lloyd-Jones, Alanna Morrison, Lawrence Phillips, Bruce Psaty, Laura Raffield, Maryam Rahafrooz, Carlos Rodriguez, Jerome Rotter, Sanjiv Shah, Amil Shah, Kent Taylor, Peter Wilson, Vanessa Xanthakis, Jacob Joseph, Yan Sun, Tamar Sofer, Vasan Ramachandran, Bing Yu

Πηγή: Circulation. 153

Abstract 68: Metabolomic Profiles of Cardiac Structure and Function and Their Associations with Incident Heart Failure in Multi-Ethnic Populations

Συγγραφείς: Eun Hye Moon, Taryn Alkis, Kai Luo, Shinhye Chung, Eric Boerwinkle, Susan Cheng, Clary Clish, Robert Gerszten, Megan Grove, Michael Hall, Lifang Hou, Scott Hutton, ROBERT KAPLAN, JORGE KIZER, Donald Lloyd-Jones, Bruce Psaty, Laura Raffield, Carlos Rodriguez, Jerome Rotter, Amil Shah, Sanjiv Shah, Kent Taylor, Kari Wong, Vanessa Xanthakis, Vasan Ramachandran, Bing Yu

Πηγή: Circulation. 153

Abstract 18: Association of Serum Metabolic Profiles with Mortality and Longevity: The Trans-Omics for Precision Medicine (TOPMed) Study

Συγγραφείς: Peidi Zhou, Taryn Alkis, Shinhye Chung, Eun Hye Moon, Christie Ballantyne, Eric Boerwinkle, Clary Clish, Robert Gerszten, Megan Grove, Lifang Hou, Scott Hutton, ROBERT KAPLAN, Rozenn Lemaitre, Donald Lloyd-Jones, Kai Luo, Matthew Nayor, Kari North, Bruce Psaty, Laura Raffield, Stephen Rich, Jerome Rotter, Usman Tahir, Kari Wong, Vanessa Xanthakis, Qibin Qi, Bing Yu

Πηγή: Circulation. 153

Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging

Συγγραφείς: Woei-Yuh Saw, Kangjin Kim, Yichen Huang, Jeong H Yun, Xiaolong Ma, Jason Bacon, Yash Pershad, Daniel Levy, George T O’Connor, Eric Boerwinkle, R Graham Barr, Stephen S Rich, Jerome I Rotter, April P Carson, Laura M Raffield, Sina A Gharib, Traci M Bartz, Bruce M Psaty, Tamar Sofer, Kari E North, Robert Kaplan, Elizabeth C Oelsner, Ani Manichaikul, Alexander G Bick, Paul Scheet, Alexander P Reiner, Gonçalo Abecasis, Francois Aguet, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Kristin Ardlie, Dan Arking, Donna K Arnett, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, Najib Ayas, John Barnard, Kathleen Barnes, Emily Barron-Casella, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Amber Beitelshees, Marcos Bezerra, Larry Bielak, Joshua Bis, John Blangero, Nathan Blue, Donald W Bowden, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Deborah Brown, Esteban Burchard, Carlos Bustamante, Brian Cade, Jonathan Cardwell, Vincent Carey, Cara Carty, Richard Casaburi, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Wei-Min Chen, Yii-Der Ida Chen, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Carolyn Crandall, James Crapo, L Adrienne Cupples, Joanne Curran, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Colleen Davis, Michelle Daya, Mariza de Andrade, Lisa de las Fuentes, Paul de Vries, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Ravi Duggirala, Jon Peter Durda, Susan K Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Patrick Ellinor, Serpil Erzurum, Charles Farber, Tasha Fingerlin, Myriam Fornage, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Mark Gladwin, David Glahn, Stephanie Gogarten, Harald Goring, Sharon Graw, Kathryn J Gray, C Charles Gu, Xiuqing Guo, Namrata Gupta, Jeff Haessler, Michael Hall, Patrick Hanly, Daniel Harris, Nicola L Hawley, Jiang He, Ben Heavner, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, John Hokanson, Karin Hoth, Chao (Agnes) Hsiung, Chii Min Hwu, Marguerite Ryan Irvin, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Sharon Kardia, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Wonji Kim, Greg Kinney, Barbara Konkle, Charles Kooperberg, Holly Kramer, Christoph Lange, Ethan Lange, Cathy Laurie, Meryl LeBoff, Wen-Jane Lee, Jonathon LeFaive, Dan Levy, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Xihong Lin, Simin Liu, Yongmei Liu, Yu Liu, Ruth J F Loos, Steven Lubitz, Kathryn Lunetta, James Luo, Ulysses Magalang, Michael Mahaney, Barry Make, Alisa Manning, JoAnn Manson, Lisa Martin, Melissa Marton, Susan Mathai, Rasika Mathias, Patrick McArdle, Merry-Lynn McDonald, Becky McNeil, Hao Mei, James Meigs, Luisa Mestroni, Ginger Metcalf, Deborah A Meyers, Emmanuel Mignot, Julie Mikulla, Yuan-I Min, Ryan L Minster, Braxton D Mitchell, Matt Moll, May Montasser, Courtney Montgomery, Donna Muzny, Josyf C Mychaleckyj, Girish Nadkarni, Rakhi Naik, Pradeep Natarajan, Sergei Nekhai, Kari North, Jeff O'Connell, Tim O'Connor, Heather Ochs-Balcom, Allan Pack, Nicholette Palmer, James Pankow, Gina Peloso, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S Phillips, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Bruce Psaty, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Laura Raffield, D C Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Susan Redline, Robert Reed, Catherine Reeves, Elizabeth Regan, Alex Reiner, Rebecca Robillard, Nicolas Robine, Dan Roden, Carolina Roselli, Jerome Rotter, Ingo Ruczinski, Alexi Runnels, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Steven Salzberg, Kevin Sandow, Vijay G Sankaran, Richa Saxena, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Vivien Sheehan, Stephanie L Sherman, Amol Shetty, Wayne Hui-Heng Sheu, M Benjamin Shoemaker, Brian Silver, Albert Vernon Smith, Jennifer Smith, Josh Smith, Nicholas Smith, Sylvia Smoller, Michael Snyder, Nona Sotoodehnia, Adrienne M Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Adam Szpiro, Hua Tang, Margaret Taub, Kent D Taylor, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Russell Tracy, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Scott Vrieze, Tarik Walker, Robert Wallace, Heming Wang, Jiongming Wang, Karol Watson, Daniel E Weeks, Joshua Weinstock, Lu-Chen Weng, Jennifer Wessel, L Keoki Williams, Scott Williams, Carla Wilson, Lara Winterkorn, Baojun Wu, Joseph Wu, Huichun Xu, Lisa Yanek, Ivana Yang, Ronit Yarden, Seyedeh Maryam Zekavat, Yingze Zhang, Wei Zhao, Xiaofeng Zhu, Elad Ziv, Michael Zody, Yasminka A Jakubek, Paul L Auer, Michael H Cho, Dawn L DeMeo

Πηγή: American Journal of Respiratory and Critical Care Medicine.

Practical Considerations for using Social Determinants of Health for Disease Prediction in All of Us

Συγγραφείς: Sara Cromer, Micah Hysong, Alisa Manning, Michael Green, Iain Konigsberg, Luciana Vargas, Megan Shuey, Leslie Lange, Jayati Sharma, LaShaunta Glover, Genevieve Wojcik, Sandra Lee, Laura Raffield

Πηγή: Res Sq

Θεματικοί όροι: Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41646423

Additive value of polygenic risk score to family history for type 2 diabetes prediction: Results from the All of US Research Database

Συγγραφείς: Emily Drzymalla, Laura Raffield, Katherine Kolor, Alain Koyama, Ramal Moonesinghe, Meda E. Pavkov, Cassandra N. Spracklen, Muin J. Khoury

Πηγή: Diabetes Care

Θεματικοί όροι: Male, Adult, Multifactorial Inheritance, Middle Aged, United States, Diabetes Mellitus, Type 2, Risk Factors, Humans, Original Article, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Aged, Genetic Risk Score

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39841967

Abstract 4346455: The ICAM1 p.K56M HFpEF Risk Variant and Measures of Adiposity

Συγγραφείς: Anushree Aneja, Kasen Culler, Jingzhong Ding, Laura Raffield, Lynette Ekunwe, Kent Taylor, Sanjiv Shah, Laura Rasmussen-Torvik, Ravi Patel

Πηγή: Circulation. 152

Abstract 4363130: Multi-Omic Analyses Identifies Novel Candidate Molecular Drivers of Coronary Artery Calcification

Συγγραφείς: Yugene Guo, Sujin Lee, Maria Murach, Kuldeep Singh, Jose Verdezoto, Gaelle Auguste, Francois Aguet, Kristin Ardlie, Clary Clish, Xiuqing Guo, Craig Johnson, Lifang Hou, Yongmei Liu, Alex Reiner, Ryan Irvin, Usman Tahir, Eric Boerwinkle, Daniel Cruz, Myriam Fornage, Nora Franceschini, Nancy Heard-Costa, Yun Li, Laura Raffield, Edwin Silverman, Matthew Budoff, Robert Gerszten, Donald Lloyd-Jones, Patricia Peyser, Wendy Post, Ramachandran Vasan, Stephen Rich, Jerome Rotter, Kent Taylor, Paul De Vries, Clint Miller, Rajeev Malhotra

Πηγή: Circulation. 152

The PRIMED Consortium: Reducing disparities in polygenic risk assessment

Συγγραφείς: Iftikhar J. Kullo, Matthew P. Conomos, Sarah C. Nelson, Sally N. Adebamowo, Ananyo Choudhury, David Conti, Stephanie M. Fullerton, Stephanie M. Gogarten, Ben Heavner, Whitney E. Hornsby, Eimear E. Kenny, Alyna Khan, Amit V. Khera, Yun Li, Iman Martin, Josep M. Mercader, Maggie Ng, Laura M. Raffield, Alex Reiner, Robb Rowley, Daniel Schaid, Adrienne Stilp, Ken Wiley, Riley Wilson, John S. Witte, Pradeep Natarajan, Sally Adebamowo, Clement Adebamowo, Nicholette Allred, Paul Auer, Jennifer Below, Palwende Romuald Boua, Kristin Boulier, Michael Bowers, Joseph Breeyear, Nilanjan Chatterjee, Tinashe Chikowore, Jaewon Choi, Matthew Conomos, Nancy Cox, Sinead Cullina, Burcu Darst, Aaron Deutsch, Yi Ding, Todd Edwards, Eleazar Eskin, Segun Fatumo, Jose Florez, Nelson Freimer, Stephanie Fullerton, Tian Ge, Daniel Geschwind, Chris Gignoux, Stephanie Gogarten, Mark Goodarzi, Xiuqing Guo, Christopher Haiman, Neil Hanchard, Scott Hazelhurst, Susan Heckbert, Jibril Hirbo, Whitney Hornsby, Kangcheng Hou, Qinqin Huang, Alicia Huerta, Guoqian Jiang, Katherine Johnston, Linda Kachuri, Takashi Kadowaki, Abram Bunya Kamiza, Eimear Kenny, Sarah Kerns, Joohyun Kim, Iain Konigsberg, Charles Kooperberg, Matt Kosel, Peter Kraft, Iftikhar Kullo, Soo-Heon Kwak, Leslie Lange, Ethan Lange, Loic Le Marchand, Hyunsuk Lee, Aaron Leong, Meng Lin, Kirk Lohmueller, Ruth Loos, Kevin Lu, Ravi Mandia, Alisa Manning, Alicia Martin, Hilary Martin, Rasika Mathias, James Meigs, Josep Mercader, Rachel Mester, Mariah Meyer, Tyne Miller-Fleming, Braxton Mitchell, Nicola Mulder, Jie Na, Sarah Nelson, Kristjan Norland, Loes Olde Loohuis, Suna Onengut-Gumuscu, Ebuka Oneyobi, Roel Ophoff, Paivi Pajukanta, Bogdan Pasaniuc, Aniruddh Patel, Ulrike Peters, Jimmy Phuong, Michael Preuss, Bruce Psaty, Laura Raffield, Michele Ramsay, Alexander Reiner, Kenneth Rice, Stephen Rich, Jerome Rotter, Bryce Rowan, Yunfeng Ruan, Lori Sakoda, Siram Sankararaman, Dan Schaid, Dan Schrider, Philip Schroeder, Ruhoilah Shemirani, Jonathan Shortt, Megan Shuey, Xueling Sim, Roelof A.J. Smit, Johanna Smith, Lucia Sobrin, Lauren Stalbow, Daniel Stram, Ken Suzuki, Lukasz Szczerbinski, Ran Tao, Bamidele Tayo, Timothy Thornton, Buu Truong, Teresa Tusie, Miriam Udler, David van Heel, Luciana B. Vargas, Vidhya Venkateswaran, Ying Wang, Jennifer Wessel, Laura Wiley, Lynne Wilkens, John Witte, Genevieve Wojcik, Quenna Wong, Toshimasa Yamauchi, Lisa Yanek, Yue Yu, Haoyu Zhang, Yuji Zhang, Michael Zhong

Πηγή: Am J Hum Genet

Θεματικοί όροι: Multifactorial Inheritance, Phenotype, Genotype, Risk Factors, Neoplasms, Perspective, Humans, Genetic Predisposition to Disease, Risk Assessment, Genome-Wide Association Study

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39561770
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