Salvianic acid A alleviates hepatic fibrosis by inhibiting the AKT1/NF-κB axis.

Συγγραφείς: Hu J; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan, 430070, China; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China., Zhang J; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China., Ge X; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China., Li S; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China., Li X; Wuhan Guangxing Scientific Research Co., LTD, 388 Gaoxin 2 Road, Wuhan, 430206, China., Zhang T; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China., Li X; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China., He M; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China. Electronic address: menghe@whut.edu.cn., Gao G; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan, 430070, China; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China. Electronic address: gbgao@whut.edu.cn., Sun T; State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan, 430070, China; Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, School of Chemistry, Chemical Engineering and Life Science, Wuhan Univ ersity of Technology, 122 Luoshi Road, Wuhan, 430070, China. Electronic address: suntl@whut.edu.cn.

Πηγή: European journal of pharmacology [Eur J Pharmacol] 2026 Oct 28; Vol. 1034, pp. 179304. Date of Electronic Publication: 2026 Sep 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/antagonists & inhibitors , NF-kappa B*/metabolism , NF-kappa B*/antagonists & inhibitors , Lactates*/pharmacology , Lactates*/therapeutic use , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/pathology , Liver Cirrhosis*/chemically induced , Liver Cirrhosis*/metabolism , Antifibrotic Agents*/pharmacology , Antifibrotic Agents*/therapeutic use, Signal Transduction/drug effects ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/pathology ; Hepatic Stellate Cells/metabolism ; Liver/drug effects ; Liver/pathology ; Transforming Growth Factor beta1/pharmacology ; Animals ; Mice ; Male ; Carbon Tetrachloride ; Humans ; Mice, Inbred C57BL ; Cell Line ; Molecular Docking Simulation

Salvianolic acid a alleviates myocardial ischemia-reperfusion injury in rats via SIRT1-mediated inhibition of oxidative stress and inflammation.

Συγγραφείς: Chen Z; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China; Xuzhou Central Hospital, Southeast University, Xuzhou 221000, Jiangsu, China., Cao Y; School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Bo H; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China., Yang Y; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China., Liu D; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China., Mao C; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China., Wu Y; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China; Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215000, China., Guo X; School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Shen J; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. Electronic address: shenjp@jsatcm.com., Pei K; School of Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China. Electronic address: peike@njucm.edu.cn., Xu X; The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China. Electronic address: xuxiaojin@jsatcm.com.

Πηγή: International immunopharmacology [Int Immunopharmacol] 2026 Oct 15; Vol. 187, pp. 117236. Date of Electronic Publication: 2026 Aug 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Sirtuin 1*/metabolism , Sirtuin 1*/genetics , Lactates*/therapeutic use , Lactates*/pharmacology , Myocardial Reperfusion Injury*/drug therapy , Myocardial Reperfusion Injury*/metabolism , Caffeic Acids*/therapeutic use , Caffeic Acids*/pharmacology , Anti-Inflammatory Agents*/therapeutic use , Anti-Inflammatory Agents*/pharmacology, Oxidative Stress/drug effects ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Signal Transduction/drug effects ; Inflammation/drug therapy ; Myocytes, Cardiac/drug effects ; Animals ; Male ; Rats ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Cell Line ; Humans ; Disease Models, Animal

Exploring the molecular mechanism of danshensu targeting PANoptosis therapy for stroke based on multi omics and experimental verification.

Συγγραφείς: Su Y; Department of Neurology, Guangxi Intermational Zhuang Medicine Hospital Affliated to Guangxi University of Chinese Medicine, Nanning City, Guangxi Zhuang Autonomous Region, China. Electronic address: Suyh1999@163.com., Huang H; Department of Neurology, Guangxi Intermational Zhuang Medicine Hospital Affliated to Guangxi University of Chinese Medicine, Nanning City, Guangxi Zhuang Autonomous Region, China. Electronic address: huanghaifeng1590@163.com., Qin H; Department of Neurology, Guangxi Intermational Zhuang Medicine Hospital Affliated to Guangxi University of Chinese Medicine, Nanning City, Guangxi Zhuang Autonomous Region, China. Electronic address: qinh2022@gxtcmu.edu.cn.

Πηγή: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2026 Oct 01; Vol. 833, pp. 154441. Date of Electronic Publication: 2026 Aug 13.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lactates*/pharmacology , Lactates*/therapeutic use , Stroke*/drug therapy , Stroke*/genetics , Stroke*/pathology , Stroke*/metabolism , Necroptosis*/drug effects , Necroptosis*/genetics, Drugs, Chinese Herbal/pharmacology ; Apoptosis/drug effects ; Microglia/drug effects ; Microglia/metabolism ; Transcriptome/drug effects ; Animals ; Molecular Docking Simulation ; Humans ; Mice ; Cell Line ; Salvia miltiorrhiza

Activated Carbon Functionalization for Lipase Immobilization: Characterization, Hydrolytic Activity, and Ethyl Lactate Synthesis.

Συγγραφείς: Nascimento PA; Process Engineering Laboratory, State University of Southwestern Bahia, Itapetinga, 45700-000, Bahia, Brazil., Borges JF; Process Engineering Laboratory, State University of Southwestern Bahia, Itapetinga, 45700-000, Bahia, Brazil., Santos MPF; Process Engineering Laboratory, State University of Southwestern Bahia, Itapetinga, 45700-000, Bahia, Brazil.; Department of Agroindustry, Federal University of Sergipe, Nossa Senhora da Gloria, Sergipe, 49680-000, Brazil., Alves AN; Process Engineering Laboratory, State University of Southwestern Bahia, Itapetinga, 45700-000, Bahia, Brazil., Santos LS; Department of Animal and Rural Technology, State University of Southwestern Bahia, Itapetinga, 45700-000, Bahia, Brazil., Fontan RDCI; Process Engineering Laboratory, State University of Southwestern Bahia, Itapetinga, 45700-000, Bahia, Brazil., Bonomo RCF; Process Engineering Laboratory, State University of Southwestern Bahia, Itapetinga, 45700-000, Bahia, Brazil., Yang W; School of Life and Environmental Sciences, Deakin University, Geelong, VIC, 3216, Australia., Veloso CM; Department of Natural Science, State University of Southwestern Bahia, Vitoria da Conquista, 45083-900, Bahia, Brazil. crisvel@uesb.edu.br.

Πηγή: Applied biochemistry and biotechnology [Appl Biochem Biotechnol] 2026 Oct; Vol. 198 (10), pp. 7831-7856. Date of Electronic Publication: 2026 Jul 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Humana Press Country of Publication: United States NLM ID: 8208561 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0291 (Electronic) Linking ISSN: 02732289 NLM ISO Abbreviation: Appl Biochem Biotechnol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lipase*/chemistry , Lipase*/metabolism , Enzymes, Immobilized*/chemistry , Enzymes, Immobilized*/metabolism , Lactates*/chemical synthesis , Lactates*/chemistry , Charcoal*/chemistry , Fungal Proteins*/chemistry, Candida/enzymology ; Iridoids/chemistry ; Hydrolysis ; Animals ; Esterification ; Saccharomycetales

SCR Organism: Diutina rugosa

Temporally programmed dual-function scaffold with simultaneous cellulose and calcium lactate regeneration for enhanced osteogenesis via lactate-induced OR5AN1 activation.

Συγγραφείς: Nonjola SC; Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Gyeonggi-do, Republic of Korea., Kim JI; Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Gyeonggi-do, Republic of Korea. Electronic address: ji.cha3311@gmail.com., Lee S; Department of Orthopedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Gyeonggi-do, Republic of Korea; Department of Anatomy, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Gyeonggi-do, Republic of Korea; SL Bio, Inc., 43, Beolmal-ro 30beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea. Electronic address: lsceline78@gmail.com.

Πηγή: Carbohydrate polymers [Carbohydr Polym] 2026 Sep 15; Vol. 388, pp. 125590. Date of Electronic Publication: 2026 Jun 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cellulose*/chemistry , Cellulose*/analogs & derivatives , Cellulose*/pharmacology , Osteogenesis*/drug effects , Tissue Scaffolds*/chemistry , Lactates*/chemistry , Lactates*/pharmacology , Calcium Compounds*/chemistry , Calcium Compounds*/pharmacology, Bone Regeneration/drug effects ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/cytology ; Lactic Acid/chemistry ; Chemokine CXCL12/chemistry ; Animals ; Humans ; Rats ; Male ; Rats, Sprague-Dawley

Danshensu derivative mitigate cerebral ischemia-reperfusion injury via the PI3K-AKT-CREB signaling pathway.

Συγγραφείς: Bai F; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, China; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, 518118, China., Liu T; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China., Yang R; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, China., Qu Y; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China., Liu X; Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, China., Wang J; Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin, 150081, China. Electronic address: wangjinhui@hrbmu.edu.cn., Li C; School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen, 518118, China. Electronic address: lichunli_2014@126.com.

Πηγή: Journal of ethnopharmacology [J Ethnopharmacol] 2026 Sep 15; Vol. 368, pp. 121785. Date of Electronic Publication: 2026 Apr 30.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Reperfusion Injury*/drug therapy , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Lactates*/pharmacology , Lactates*/therapeutic use , Brain Ischemia*/drug therapy , Neuroprotective Agents*/pharmacology, Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Cell Survival/drug effects ; Brain/drug effects ; Brain/blood supply ; Cell Movement/drug effects ; Infarction, Middle Cerebral Artery/drug therapy ; Animals ; Rats, Sprague-Dawley ; Male ; Rats ; Cells, Cultured

Salvianolic acid A promotes angiogenesis after stroke by targeting AKT to alleviate oxidative stress.

Συγγραφείς: Wang L; Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Zhang S; Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China; Air Force Medical Center, PLA, Air Force Medical University, Beijing, 100142, China., Liu C; Department of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, 100032, China., Zhao Z; Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Sun W; Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Du G; Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China., Kong L; Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. Electronic address: konglinglei@imm.ac.cn.

Πηγή: Brain research bulletin [Brain Res Bull] 2026 Oct 15; Vol. 245, pp. 112112. Date of Electronic Publication: 2026 Sep 08.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605818 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2747 (Electronic) Linking ISSN: 03619230 NLM ISO Abbreviation: Brain Res Bull Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Oxidative Stress*/drug effects , Proto-Oncogene Proteins c-akt*/metabolism , Lactates*/pharmacology , Caffeic Acids*/pharmacology , Stroke*/drug therapy , Stroke*/metabolism , Angiogenesis*/drug effects , Neovascularization, Physiologic*/drug effects, Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Signal Transduction/drug effects ; Animals ; Male ; Humans ; Rats, Sprague-Dawley ; Rats ; Disease Models, Animal

Phenyllactic acid exposure suppresses Microcystis aeruginosa growth with concurrent PSII photochemical impairment and increased extracellular microcystin accumulation.

Συγγραφείς: Cheng J; Shandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, 252000, China., Zhu Z; Shandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, 252000, China., Wang S; Shandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, 252000, China., Guo S; Shandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, 252000, China., Li J; School of Marine Sciences (State Key Laboratory of Marine Resources Utilization in South China Sea), Hainan University, Haikou, 570100, China. Electronic address: jiashun.li@hainanu.edu.cn., Xu C; Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 101408, China., Wang Y; College of Artificial Intelligence, Pingdingshan University, Henan, 467000, China., Zhang C; Shandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng, 252000, China., Zhang K; School of Marine Sciences (State Key Laboratory of Marine Resources Utilization in South China Sea), Hainan University, Haikou, 570100, China. Electronic address: kzhang@hainanu.edu.cn.

Πηγή: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2026 Oct 01; Vol. 324, pp. 120863. Date of Electronic Publication: 2026 Oct 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Microcystis*/drug effects , Microcystis*/growth & development , Microcystis*/metabolism , Microcystins*/metabolism , Lactates*/toxicity , Photosystem II Protein Complex*/metabolism , Photosystem II Protein Complex*/drug effects, Photosynthesis/drug effects ; Chlorophyll/metabolism ; Superoxide Dismutase/metabolism ; Chlorophyll A

Salvianolic Acid A Inhibits Ferroptosis in Endothelial Cells and the Progression of Atherosclerosis by Augmenting the Mitochondrial Homeostasis Pathway Associated With Adiponectin Receptor 1.

Συγγραφείς: Zhu J; The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, China.; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China., Guo J; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China.; School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China., Liu J; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China.; School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China., Chen C; Academy of Chinese Medical Science, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Chen H; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China.; School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China., Wang C; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China.; School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China., Yuan A; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China.; School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China., Lu D; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China.; School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China., Le Y; Lipid Metabolism Institute (Molecular Medicine Institute), Zhejiang Chinese Medical University, Hangzhou, China.; School of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

Πηγή: Phytotherapy research : PTR [Phytother Res] 2026 Oct; Vol. 40 (10), pp. 5831-5852. Date of Electronic Publication: 2026 Jul 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ferroptosis*/drug effects , Atherosclerosis*/drug therapy , Atherosclerosis*/metabolism , Caffeic Acids*/pharmacology , Mitochondria*/drug effects , Mitochondria*/metabolism , Lactates*/pharmacology , Receptors, Adiponectin*/metabolism, Human Umbilical Vein Endothelial Cells/drug effects ; Reactive Oxygen Species/metabolism ; Homeostasis/drug effects ; Signal Transduction/drug effects ; Lipid Peroxidation/drug effects ; AMP-Activated Protein Kinases/metabolism ; Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE

Integrative multi-omics reveals that salvianolic acid a protects against septic liver injury by remodeling amino acid metabolism and redox homeostasis.

Συγγραφείς: Li P; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., He Y; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Fan Y; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Jia X; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Pei J; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China., Liu Y; Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China., Gu X; The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471000, China. Electronic address: hkdguxy@163.com., Li L; Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. Electronic address: lili0941@163.com.

Πηγή: Protein and peptide letters [Protein Pept Lett] 2026 Sep; Vol. 34 (2), pp. 73-85. Date of Electronic Publication: 2026 Sep 22.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 9441434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-5305 (Electronic) Linking ISSN: 09298665 NLM ISO Abbreviation: Protein Pept Lett Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Caffeic Acids*/pharmacology , Sepsis*/metabolism , Sepsis*/drug therapy , Sepsis*/complications , Lactates*/pharmacology , Liver*/metabolism , Liver*/pathology , Liver*/drug effects , Liver*/injuries , Amino Acids*/metabolism , Liver Diseases*/metabolism , Liver Diseases*/etiology , Liver Diseases*/prevention & control , Liver Diseases*/drug therapy , Liver Diseases*/pathology , Protective Agents*/pharmacology, Oxidation-Reduction/drug effects ; Homeostasis/drug effects ; Animals ; Mice ; Male ; Multiomics ; Mice, Inbred C57BL ; Proteomics

Sodium danshensu mitigates myocardial ischemia-reperfusion injury by attenuating ferroptosis through Nrf2/SLC7A11/GPX4 pathway.

Συγγραφείς: Liu P; School of Medicine Shanghai University, Shanghai 200444, China., Luo Y; School of Medicine Shanghai University, Shanghai 200444, China., Zhang Y; College of Pharmacology, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China., Dong Y; Department of Pharmacy, Shanghai Pudong New Area People's Hospital, Shanghai 201200, PR China., Qiu Z; Shenzhen Medicines and Health Products Imp, & Exf, Co, Ltd, Shenzhen 518001, China. Electronic address: boazhk@126.com., Chen T; School of Medicine Shanghai University, Shanghai 200444, China. Electronic address: cttc1990@126.com., Zhang C; School of Medicine Shanghai University, Shanghai 200444, China. Electronic address: zc843016@shu.edu.cn.

Πηγή: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2026 Aug; Vol. 513, pp. 117863. Date of Electronic Publication: 2026 May 12.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Ferroptosis*/drug effects , NF-E2-Related Factor 2*/metabolism , Myocardial Reperfusion Injury*/drug therapy , Myocardial Reperfusion Injury*/prevention & control , Myocardial Reperfusion Injury*/pathology , Myocardial Reperfusion Injury*/metabolism , Phospholipid Hydroperoxide Glutathione Peroxidase*/metabolism , Lactates*/pharmacology, Signal Transduction/drug effects ; Oxidative Stress/drug effects ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Animals ; Male ; Mice ; Mice, Inbred C57BL

Salvianolic acid A inhibits tumor cell proliferation and induces chromosomal abnormalities by blocking the citrullinating enzyme PADs.

Συγγραφείς: Chen J; Center for Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine, Shanghai, China., Wang T; Center for Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine, Shanghai, China., Gao B; Center for Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine, Shanghai, China., Ke X; Center for Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine, Shanghai, China., Zhou X; Center for Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine, Shanghai, China. Electronic address: zhouxianglian@shutcm.edu.cn., Qu Y; Center for Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China; State Key Laboratory of Integration and Innovation of Classical Formula and Modern Chinese Medicine, Shanghai, China. Electronic address: yiqu@shutcm.edu.cn.

Πηγή: Life sciences [Life Sci] 2026 Aug 01; Vol. 398, pp. 124444. Date of Electronic Publication: 2026 May 08.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cell Proliferation*/drug effects , Caffeic Acids*/pharmacology , Lactates*/pharmacology , Chromosome Aberrations*/chemically induced , Chromosome Aberrations*/drug effects, Citrulline/metabolism ; Histones/metabolism ; Humans ; Animals ; Mice ; Cell Line, Tumor ; Molecular Docking Simulation

Salvianolic Acid A Relieves Acute Lung Injury by Promoting the Expression of FOXO1 and Activating Autophagy Through the Inhibition of miR-217-5p.

Συγγραφείς: Liu X; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., Shi Y; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., Huang L; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., Chen H; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., Fan R; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., Zhang H; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., Li Q; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., Yan N; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China., He M; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China. hemaiding@kmmu.edu.cn., Yang Y; Department of Rehabilitation Medicine, Yunnan Qujing Central Hospital (Qujing No.1 Hospital), Qujing, 655000, Yunnan, China. yangyonghua@kmmu.edu.cn.

Πηγή: Biochemical genetics [Biochem Genet] 2026 Aug; Vol. 64 (4), pp. 5225-5244. Date of Electronic Publication: 2025 Nov 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Acute Lung Injury*/drug therapy , Acute Lung Injury*/metabolism , Acute Lung Injury*/pathology , Acute Lung Injury*/chemically induced , MicroRNAs*/genetics , MicroRNAs*/metabolism , Forkhead Box Protein O1*/genetics , Forkhead Box Protein O1*/metabolism , Autophagy*/drug effects , Lactates*/pharmacology , Caffeic Acids*/pharmacology, Gene Expression Regulation/drug effects ; Animals ; Mice ; Cell Line ; Lipopolysaccharides ; Male

A validated chiral LC-MS/MS method for enantioselective quantification of aromatic lactic acids in human faeces.

Συγγραφείς: Gaafar AM; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark., Stolberg-Mathieu G; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark., Roager HM; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark. Electronic address: hero@nexs.ku.dk., La Barbera G; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg C, Denmark. Electronic address: glb@nexs.ku.dk.

Πηγή: Journal of chromatography. A [J Chromatogr A] 2026 Jul 19; Vol. 1779, pp. 466997. Date of Electronic Publication: 2026 Apr 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9318488 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3778 (Electronic) Linking ISSN: 00219673 NLM ISO Abbreviation: J Chromatogr A Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Feces*/chemistry , Liquid Chromatography-Mass Spectrometry*/methods , Tandem Mass Spectrometry*/methods , Lactates*/analysis , Lactates*/chemistry, Lactic Acid/analysis ; Lactic Acid/chemistry ; Humans ; Stereoisomerism ; Reproducibility of Results ; Limit of Detection

Tanshinone IIA, salvianic acid A, salvianolic acid B, and hydroxysafflor yellow A reduce cerebral injury via TGF-β1/Smad3 pathway.

Συγγραφείς: Luo B; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China; Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China. Electronic address: 13008448104@163.com., Zhang W; Department of Pharmacy, Xi'an Children's Hospital, The Affiliated Children Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710002, China. Electronic address: zhangwen125383@163.com., Zhang Y; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China., Lei Y; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China., Xu Q; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China., Li W; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China., Yu J; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China., Zhu X; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China., Miao Q; Department of Neurology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xian, Shanxi 712000, China., Zhu H; School of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China. Electronic address: 13008448104@163.com.

Πηγή: Neuroscience letters [Neurosci Lett] 2026 Jun 30; Vol. 881, pp. 138622. Date of Electronic Publication: 2026 May 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7972 (Electronic) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Benzofurans*/pharmacology , Benzofurans*/therapeutic use , Benzofurans*/administration & dosage , Transforming Growth Factor beta1*/metabolism , Chalcone*/analogs & derivatives , Chalcone*/pharmacology , Chalcone*/therapeutic use , Chalcone*/administration & dosage , Abietanes*/pharmacology , Abietanes*/therapeutic use , Abietanes*/administration & dosage , Quinones*/pharmacology , Quinones*/administration & dosage , Quinones*/therapeutic use , Smad3 Protein*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Reperfusion Injury*/metabolism , Reperfusion Injury*/pathology , Reperfusion Injury*/drug therapy , Lactates*/pharmacology , Lactates*/administration & dosage, Signal Transduction/drug effects ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/pathology ; Infarction, Middle Cerebral Artery/drug therapy ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Animals ; Rats, Sprague-Dawley ; Depsides ; Male ; Rats ; Caffeic Acids

Elucidating the therapeutic targets and multi-target mechanisms of salvianolic acid A for diabetic nephropathy.

Συγγραφείς: Fu T; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixian'ge Street, Xicheng District, Beijing, 100053, People's Republic of China., Xiong Z; Hubei Provincial Hospital of Traditional Chinese Medicine, No. 4, Huaishu Gang Road, Wuchang District, Wuhan, 430065, Hubei Province, People's Republic of China., Tao H; The Second Affiliated Hospital of Liaoning, University of Traditional Chinese Medicine, No. 33, Beiling Street, Huanggu District, Shenyang, 110034, Liaoning Province, People's Republic of China. taohw@126.com., Zhan Y; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixian'ge Street, Xicheng District, Beijing, 100053, People's Republic of China. 18812519897@163.com.

Πηγή: Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2026 Jun 24; Vol. 37 (1). Date of Electronic Publication: 2026 Jun 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: United States NLM ID: 9100916 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1777 (Electronic) Linking ISSN: 09388990 NLM ISO Abbreviation: Mamm Genome Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Diabetic Nephropathies*/drug therapy , Diabetic Nephropathies*/genetics , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology , Lactates*/pharmacology , Lactates*/therapeutic use , Lactates*/chemistry , Caffeic Acids*/pharmacology , Caffeic Acids*/chemistry , Caffeic Acids*/therapeutic use, Podocytes/drug effects ; Podocytes/metabolism ; Podocytes/pathology ; Humans ; Molecular Docking Simulation ; Animals

Cyclization, amino acid coupling, docking-based virtual screening and SAR: showing a strategy of the structural modification for salvianic acid A.

Συγγραφείς: Wu J; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China.; Chinese Institutes for Medical Research, Beijing, China., Zhang X; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., An W; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., Yang Y; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., Zhang P; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., Wang Y; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., Zhao S; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., Feng Q; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., Zhao M; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China., Peng S; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Capital Medical University, Beijing, China.

Πηγή: Future medicinal chemistry [Future Med Chem] 2026 Jun; Vol. 18 (11), pp. 1391-1403. Date of Electronic Publication: 2026 Apr 24.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lactates*/chemistry , Lactates*/pharmacology , Lactates*/chemical synthesis , Lactates*/therapeutic use , Amino Acids*/chemistry , Platelet Aggregation Inhibitors*/chemistry , Platelet Aggregation Inhibitors*/pharmacology , Platelet Aggregation Inhibitors*/chemical synthesis , Molecular Docking Simulation*, Platelet Aggregation/drug effects ; Thrombosis/drug therapy ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism ; P-Selectin/blood ; Animals ; Male ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Humans

Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's disease pathology via the p38 MAPK/NF-κB pathway based on network pharmacology and experimental validation.

Συγγραφείς: Xiao S; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China., Han Y; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China., Yan J; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China., Wu L; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China., Lin H; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China., Yuan C; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China., Song C; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China., Ye J; Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China. Electronic address: yejinwang@szu.edu.cn.

Πηγή: International immunopharmacology [Int Immunopharmacol] 2026 Jun 01; Vol. 178, pp. 116594. Date of Electronic Publication: 2026 Apr 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Alzheimer Disease*/drug therapy , Alzheimer Disease*/pathology , Alzheimer Disease*/metabolism , p38 Mitogen-Activated Protein Kinases*/metabolism , NF-kappa B*/metabolism , Caffeic Acids*/therapeutic use , Caffeic Acids*/pharmacology , Lactates*/therapeutic use , Lactates*/pharmacology , Anti-Inflammatory Agents*/therapeutic use , Anti-Inflammatory Agents*/pharmacology , Neuroinflammatory Diseases*/drug therapy, Signal Transduction/drug effects ; Amyloid beta-Peptides/metabolism ; Cytokines/metabolism ; Animals ; Humans ; Mice ; Network Pharmacology ; Mice, Transgenic ; Disease Models, Animal ; Male ; Cell Line ; Molecular Docking Simulation

Parvimonas micra promotes carcinogenesis of colorectal cancer through phenyllactic acid-induced DNA damage.

Συγγραφείς: Guo S; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; School of Public Health, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Cao M; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Wu J; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Ma W; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Liang D; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Xie H; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China.; Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Xie Y; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Luo Z; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Lai P; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Liu D; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China., Zeng W; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Zheng J; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Xing M; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Yin X; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China., Xia M; School of Public Health, Sun Yat-Sen University, Guangzhou, China., He Z; Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-Sen University), Ministry of Education, Guangzhou, China.

Πηγή: Clinical and translational medicine [Clin Transl Med] 2026 May; Vol. 16 (5), pp. e70667.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 101597971 Publication Model: Print Cited Medium: Internet ISSN: 2001-1326 (Electronic) Linking ISSN: 20011326 NLM ISO Abbreviation: Clin Transl Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Colorectal Neoplasms*/microbiology , Colorectal Neoplasms*/genetics , DNA Damage*/drug effects , Lactates*/adverse effects , Lactates*/metabolism , Carcinogenesis*, Feces/microbiology ; Animals ; Humans ; Mice ; Male ; Female ; Gastrointestinal Microbiome ; Disease Models, Animal

Salvianolic acid C alleviates acute kidney injury by restoring fructose-1,6-bisphosphatase 1-mediated gluconeogenesis.

Συγγραφείς: Chen J; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China., Li Y; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China., Zhou P; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China., Zou S; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China., Zhao J; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China., Wu M; Key Laboratory of Liver and Kidney Diseases, Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, TCM Institute of Kidney Disease of Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China., Wang L; Department of Nephrology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.

Πηγή: Renal failure [Ren Fail] 2026 Dec; Vol. 48 (1), pp. 2629902. Date of Electronic Publication: 2026 Mar 08.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/pathology , Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/metabolism , Fructose-Bisphosphatase*/metabolism , Gluconeogenesis*/drug effects , Reperfusion Injury*/drug therapy , Reperfusion Injury*/complications , Polyphenols*/pharmacology , Alkenes*/pharmacology , Lactates*/pharmacology, Cisplatin/toxicity ; Forkhead Box Protein O1/metabolism ; Apoptosis/drug effects ; Kidney/pathology ; Kidney/drug effects ; Drugs, Chinese Herbal/pharmacology ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Salvia miltiorrhiza/chemistry ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Disease Models, Animal ; Molecular Docking Simulation ; Benzofurans