Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity.

Authors: Andreia D Magalhães, Marc Emmenegger, Elena De Cecco, Manfredi Carta, Karl Frontzek, Andra Chincisan, Jingjing Guo, Simone Hornemann, Adriano Aguzzi

Source: PLoS Biology, Vol 23, Iss 11, p e3003488 (2025)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/a831d2d29b764370861d86527b4f18e2

Genome wide association study of clinical duration and age at onset of sporadic CJD

Authors: Holger Hummerich, Helen Speedy, Tracy Campbell, Lee Darwent, Elizabeth Hill, Steven Collins, Christiane Stehmann, Gabor G. Kovacs, Michael D. Geschwind, Karl Frontzek, Herbert Budka, Ellen Gelpi, Adriano Aguzzi, Sven J. van der Lee, Cornelia M. van Duijn, Pawel P. Liberski, Miguel Calero, Pascual Sanchez-Juan, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Stéphane Haïk, Jean-Phillipe Brandel, Angela Mammana, Sabina Capellari, Anna Poleggi, Anna Ladogana, Maurizio Pocchiari, Saima Zafar, Stephanie Booth, Gerard H. Jansen, Aušrinė Areškevičiūtė, Eva Løbner Lund, Katie Glisic, Piero Parchi, Peter Hermann, Inga Zerr, Brian S. Appleby, Jiri Safar, Pierluigi Gambetti, John Collinge, Simon Mead

Source: PLoS ONE, Vol 19, Iss 7 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11280162/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/86b1c5c60f604e1cacf2a7f5c8b453af

Loss of PIKfyve drives the spongiform degeneration in prion diseases

Authors: Asvin K K Lakkaraju, Karl Frontzek, Emina Lemes, Uli Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi

Source: EMBO Molecular Medicine, Vol 13, Iss 9, Pp 1-17 (2021)

Subject Terms: neurodegeneration, palmitoylation, prion, spongiosis, unfolded protein response, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/bf837fe83aa247b2b6e9fcd8e3b7e998

Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report

Authors: Christian Koch, Patrick Roth, Juliane Fleischer, Todor Popov, Karl Frontzek, Bettina Schreiner, Markus G. Manz, Simone Unseld, Antonia M. S. Müller, Norman F. Russkamp

Source: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/11/1/e006059.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/a2020bdc501145f7a8e17396c48a49e8

Long-Term Persisting SARS-CoV-2 RNA and Pathological Findings: Lessons Learnt From a Series of 35 COVID-19 Autopsies

Authors: Umberto Maccio, Annelies S. Zinkernagel, Reto Schuepbach, Elsbeth Probst-Mueller, Karl Frontzek, Silvio D. Brugger, Daniel Andrea Hofmaenner, Holger Moch, Zsuzsanna Varga

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: COVID-19, long-COVID, SARS-CoV-2 RNA PCR, postmortal swabs, pulmonary superinfections, histopathology, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.778489/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/032f9a675c544869948273fc48d4a428

Protective anti‐prion antibodies in human immunoglobulin repertoires

Authors: Assunta Senatore, Karl Frontzek, Marc Emmenegger, Andra Chincisan, Marco Losa, Regina Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi

Source: EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-19 (2020)

Subject Terms: anti‐PrP antibodies, human immunological repertoires, next‐generation sequencing, phage display, prion disease, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/c41b503363134ee683fd9afef525f6b5

Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish

Authors: Gianluca D'Agati, Elena María Cabello, Karl Frontzek, Elisabeth J. Rushing, Robin Klemm, Mark D. Robinson, Richard M. White, Christian Mosimann, Alexa Burger

Source: Disease Models & Mechanisms, Vol 12, Iss 7 (2019)

Subject Terms: Notochord, TBXT, RTK, Cancer, Danio rerio, In vivo models, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/12/7/dmm039545; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/7db878b95a154afab6a81dc53ffc19aa

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.

Authors: Marco Bardelli, Karl Frontzek, Luca Simonelli, Simone Hornemann, Mattia Pedotti, Federica Mazzola, Manfredi Carta, Valeria Eckhardt, Rocco D'Antuono, Tommaso Virgilio, Santiago F González, Adriano Aguzzi, Luca Varani

Source: PLoS Pathogens, Vol 14, Iss 10, p e1007335 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/b333e425dac04363bafbe5d00b152b89

Consensus statement on microglial and macrophage functions in gliomas

Authors: Yuqi Zheng, Islam Alzoubi, Manuel B. Graeber, Atul Anand, Lara Barazzuol, Mario Dorostkar, Karl Frontzek, Anna Golebiewska, Costas G. Hadjipanayis, Tibor Hortobagyi, Azzam Ismail, Gerard H. Jansen, Bozena Kaminska, Daniel Kirschenbaum, Yoshihiro Komohara, Bjarne Winther Kristensen, Kevin S. Lee, Emilie Le Rhun, Q. Richard Lu, Kaspar Matiasek, Christian Mawrin, Alessandro Michelucci, Nicola Montemurro, Marc-André Mouthon, Quan Liu, Regina Reimann, Roman Sankowski, Alejandro Schcolnik-Cabrera, Michael Schulz, Christian M. Schürch, Marius Schwabenland, Aurélie Tchoghandjian, Indrė Valiulytė-Simaitė, Mariano S. Viapiano, Tobias Weiss, Michael Weller, Max Wintermark

Source: Zheng, Y, Alzoubi, I, Graeber, M B, Anand, A, Barazzuol, L, Dorostkar, M, Frontzek, K, Golebiewska, A, Hadjipanayis, C G, Hortobagyi, T, Ismail, A, Jansen, G H, Kaminska, B, Kirschenbaum, D, Komohara, Y, Kristensen, B W, Lee, K S, Le Rhun, E, Lu, Q R, Matiasek, K, Mawrin, C, Michelucci, A, Montemurro, N, Mouthon, M A, Liu, Q, Reimann, R, Sankowski, R, Schcolnik-Cabrera, A, Schulz, M, Schürch, C M, Schwabenland, M, Tchoghandjian, A, Valiulytė-Simaitė, I, Viapiano, M S, Weiss, T, Weller, M & Wintermark, M 2026, ' Consensus statement on microglial and macrophage functions in gliomas ', Acta Neuropathologica, vol. 151, no. 1, 39 . https://doi.org/10.1007/s00401-026-02999-3

Subject Terms: Macrophages, Neurooncology, Glioma, Immunotherapy, Microglia

File Description: application/pdf

Chromosome X-wide association study in multiple system atrophy identifies sex-differential risk loci

Authors: Anindita Ray, Ruth Chia, Memoona Rasheed, Ece Bayram, Jinhui Ding, Ronald L Walton, Regina H Reynolds, Monica Diez-Fairen, Ignacio Alvarez, Alessandra Fanciulli, Nadia Stefanova, Klaus Seppi, Susanne Duerr, Fabian Leys, Florian Krismer, Victoria Sidoroff, Alexander Zimprich, Walter Pirker, Olivier Rascol, Alexandra Foubert-Samier, Wassilios G Meissner, François Tison, Anne Pavy-Le Traon, Maria Teresa Pellecchia, Paolo Barone, Maria Claudia Russillo, Juan Marín-Lahoz, Jaime Kulisevsky, Soraya Torres, Pablo Mir, Maria Teresa Periñán, Christos Proukakis, Viorica Chelban, Lesley Wu, Yee Y Goh, Laura Parkkinen, Michele T Hu, Christopher Kobylecki, Jennifer A Saxon, Sara Rollinson, Emily Garland, Italo Biaggioni, Irene Litvan, Ileana Rubio, Roy N Alcalay, Kimberly T Kwei, Steven J Lubbe, Qinwen Mao, Margaret E Flanagan, Rudolph J Castellani, Vikram Khurana, Alain Ndayisaba, Andrea Calvo, Gabriele Mora, Antonio Canosa, Gianluca Floris, Ryan C Bohannan, Anni Moore, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Horacio Kaufmann, Ted M Dawson, Liana S Rosenthal, Alexander Pantelyat, Marilyn S Albert, Olga Pletnikova, Juan C Troncoso, Jon Infante, Carmen Lage, Pascual Sánchez-Juan, Geidy E Serrano, Thomas G Beach, Pau Pastor, Huw R Morris, Diego Albani, Jordi Clarimon, Zane Jaunmuktane, Karl Frontzek, Tamás Révész, Tom Warner, John A Hardy, Mina Ryten, Luigi Ferrucci, Eric Topol, Ali Torkamani, Alex R DeCasien, Adriano Chiò, Philip A Low, Wolfgang Singer, William P Cheshire, Zbigniew K Wszolek, Dennis W Dickson, Bryan J Traynor, J Raphael Gibbs, Clifton L Dalgard, Owen A Ross, Henry Houlden, Sonja W Scholz

Source: Brain.

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication.

Authors: Karl Frontzek, Manuela Pfammatter, Silvia Sorce, Assunta Senatore, Petra Schwarz, Rita Moos, Katrin Frauenknecht, Simone Hornemann, Adriano Aguzzi

Source: PLoS ONE, Vol 11, Iss 9, p e0163601 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5042507?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/375f6c4ea4064a5e80ebc999936eb25c

Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting

Authors: Karl Frontzek, Mirjam I. Lutz, Adriano Aguzzi, Gabor G. Kovacs, Herbert Budka

Source: Swiss Medical Weekly, Vol 146, Iss 0304 (2016)

Subject Terms: Alzheimer pathology, amyloid-beta, beta, Creutzfeldt, dural grafting, grafting, Medicine

File Description: electronic resource

Relation: https://www.smw.ch/index.php/smw/article/view/2142; https://doaj.org/toc/1424-3997

Access URL: https://doaj.org/article/6cbdf91fc45c4eafbd5fe6f5aaefd198

Isolated insular strokes and plasma MR-proANP levels are associated with newly diagnosed atrial fibrillation: a pilot study.

Authors: Karl Frontzek, Felix Fluri, Jakob Siemerkus, Beat Müller, Achim Gass, Mirjam Christ-Crain, Mira Katan

Source: PLoS ONE, Vol 9, Iss 3, p e92421 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3960255?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/035999634c9948dea1582f2278431fe2

Multiomic Analyses Direct Hypotheses for Creutzfeldt-Jakob Disease Risk Genes

Authors: Fahri Küçükali, Elizabeth Hill, Tijs Watzeels, Holger Hummerich, Tracy Campbell, Lee Darwent, Steven Collins, Christiane Stehmann, Gabor G Kovacs, Michael D Geschwind, Karl Frontzek, Herbert Budka, Ellen Gelpi, Adriano Aguzzi, Sven J van der Lee, Cornelia M van Duijn, Pawel P Liberski, Miguel Calero, Pascual Sanchez-Juan, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Stéphane Haïk, Jean-Phillipe Brandel, Angela Mammana, Sabina Capellari, Anna Poleggi, Anna Ladogana, Dorina Tiple, Saima Zafar, Stephanie Booth, Gerard H Jansen, Aušrinė Areškevičiūtė, Eva Løbner Lund, Katie Glisic, Piero Parchi, Peter Hermann, Inga Zerr, Jiri Safar, Pierluigi Gambetti, Brian S Appleby, John Collinge, Kristel Sleegers, Simon Mead

Contributors: Küçükali, Fahri, Hill, Elizabeth, Watzeels, Tijs, Hummerich, Holger, Campbell, Tracy, Darwent, Lee, Collins, Steven, Stehmann, Christiane, Kovacs, Gabor G, Geschwind, Michael D, Mead, Simon

Source: Brain
Brain 148(9), 3350-3363 (2025). doi:10.1093/brain/awaf032
medRxiv
Küçükali, F, Hill, E, Watzeels, T, Hummerich, H, Campbell, T, Darwent, L, Collins, S, Stehmann, C, Kovacs, G G, Geschwind, M D, Frontzek, K, Budka, H, Gelpi, E, Aguzzi, A, van der Lee, S J, van Duijn, C M, Liberski, P P, Calero, M, Sanchez-Juan, P, Bouaziz-Amar, E, Laplanche, J-L, Haïk, S, Brandel, J-P, Mammana, A, Capellari, S, Poleggi, A, Ladogana, A, Tiple, D, Zafar, S, Booth, S, Jansen, G H, Areškevičiūtė, A, Lund, E L, Glisic, K, Parchi, P, Hermann, P, Zerr, I, Safar, J, Gambetti, P, Appleby, B S, Collinge, J, Sleegers, K & Mead, S 2025, ' Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes ', Brain : a journal of neurology, vol. 148, no. 9, pp. 3350-3363 . https://doi.org/10.1093/brain/awaf032

Subject Terms: multiomics, neurodegeneration, proteome-wide association studies (PWAS), sporadic Creutzfeldt-Jakob disease (sCJD), transcriptome-wide association studies (TWAS), Transcriptome: genetics, Brain, Genetic Predisposition to Disease: genetics, Creutzfeldt-Jakob Syndrome: genetics, Creutzfeldt-Jakob Syndrome, SDG 3 - Good Health and Well-being, Risk Factors, Creutzfeldt-Jakob Syndrome: metabolism, Humans, Original Article, Genetic Predisposition to Disease, Human medicine, Brain: metabolism, Transcriptome, Biology, Genome-Wide Association Study

File Description: application/pdf; application/zip

Access URL: https://pubmed.ncbi.nlm.nih.gov/39865733
https://pub.dzne.de/record/281103
https://ora.ox.ac.uk/objects/uuid:0ffef7a4-0ab7-4800-aa7e-54be50577a24
https://doi.org/10.1093/brain/awaf032
https://resolver.sub.uni-goettingen.de/purl?gro-2/147627
https://repository.uantwerpen.be/docstore/d:irua:30339
https://hdl.handle.net/10067/2161800151162165141
https://hdl.handle.net/10067/2090790151162165141
https://repository.uantwerpen.be/docstore/d:irua:25786

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Authors: Marian Hruska-Plochan, Vera I. Wiersma, Katharina M. Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D. Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann, Magdalini Polymenidou

Source: Nature

Subject Terms: DNA-Binding Proteins, Neurons, C-Reactive Protein, Neural Stem Cells, Pentraxins, Amyotrophic Lateral Sclerosis, Humans, Reproducibility of Results, Nerve Tissue Proteins, Frontotemporal Lobar Degeneration, Nerve Net, Neuroglia, Article

Access URL: https://pubmed.ncbi.nlm.nih.gov/38355792

Neurologic Involvement in Cystinosis: Focus on Brain Lesions and New Evidence of Four-repeat (4R−) Tauopathy (P6-4.004)

Authors: Tommaso Nicoletti, Andrea Bink, Birgit Helmchen, Nils Briel, Karl Frontzek, Benjamin Vlad, Ariana Gaspert, Elisabeth Boudriot, Hans Heinrich Jung, Anna Maria Reuss, Michael Weller, Tibor Hortobagyi

Source: Neurology. 102

Posttransplant Anti-GABA A Receptor Antibody-Associated Autoimmune Encephalitis

Authors: Claudio L. Togni, Karl Frontzek, Maximilian Schubring-Giese, Lukas L. Imbach, Ilijas Jelcic

Source: Neurology. 102

Subject Terms: Autoimmune Diseases of the Nervous System, Humans, Encephalitis, Hashimoto Disease, Receptors, GABA-A, Autoantibodies

Access URL: https://pubmed.ncbi.nlm.nih.gov/38452326

A conformational switch controlling the toxicity of the prion protein

Authors: Karl Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R. Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G. Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi

Contributors: Instituto de Investigação e Inovação em Saúde, DSpace at Cambridge pro (8.1), Apollo - University of Cambridge Repository, University of Zurich, Varani, Luca, Aguzzi, Adriano

Source: Nat Struct Mol Biol
Nature Structural & Molecular Biology

Subject Terms: PRP, Prion Proteins / metabolism, Prions / toxicity, Antibodies / metabolism, RESISTANT, Ligands, 14, Mice, 13/1, 1315 Structural Biology, Cerebellum / metabolism, Structural Biology, Cerebellum, 540 Chemistry, 14/19, 610 Medicine & health, 11 Medical and Health Sciences, article, Prion Proteins / chemistry, 34 Chemical sciences, 3. Good health, 631/45/460, 03 Chemical Sciences, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Prions, 101, 10208 Institute of Neuropathology, Biophysics, 101/6, Antibodies, Prion Proteins, Article, 38, 82/80, Prions / metabolism, 1312 Molecular Biology, Animals, PrPC Proteins, Molecular Biology, Science & Technology, 82, 31 Biological sciences, Cell Biology, 32 Biomedical and clinical sciences, PrPC Proteins / chemistry, 06 Biological Sciences, Prion Proteins / genetics, NMR, MICE, 631/535/1267, REPLICATION, ANTIBODIES, 13/51, 570 Life sciences, biology, PrPC Proteins / genetics, Developmental Biology

File Description: application/pdf; application/zip; text/xml; s41594_022_00814_7.pdf - application/pdf

Access URL: https://www.biorxiv.org/content/biorxiv/early/2021/09/20/2021.09.20.460912.full.pdf
https://pubmed.ncbi.nlm.nih.gov/35948768
https://hdl.handle.net/20.500.11768/132897
https://doi.org/10.1038/s41594-022-00814-7
https://www.nature.com/articles/s41594-022-00814-7
https://hdl.handle.net/10216/165533
https://www.repository.cam.ac.uk/handle/1810/340932
https://doi.org/10.1038/s41594-022-00814-7
https://doi.org/10.17863/cam.88367
https://www.zora.uzh.ch/id/eprint/221322/
https://doi.org/10.5167/uzh-221322

Prion diseases disrupt the glutamate/glutamine metabolism in skeletal muscle

Authors: Davide Caredio, Maruša Koderman, Karl Frontzek, Silvia Sorce, Mario Nuvolone, Juliane Bremer, Petra Schwarz, Stefano Sellitto, Nathalie Streichenberger, Claudia Scheckel, Adriano Aguzzi

Subject Terms: 3. Good health

Genome wide association study of clinical duration and age at onset of sporadic CJD

Authors: Holger Hummerich, Helen Speedy, Tracy Campbell, Lee Darwent, Elizabeth Hill, Steven Collins, Christiane Stehmann, Gabor G Kovacs, Michael D Geschwind, Karl Frontzek, Herbert Budka, Ellen Gelpi, Adriano Aguzzi, Sven J van der Lee, Cornelia M van Duijn, Pawel P Liberski, Miguel Calero, Pascual Sanchez-Juan, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Stéphane Haïk, Jean-Phillipe Brandel, Angela Mammana, Sabina Capellari, Anna Poleggi, Anna Ladogana, Maurizio Pocchiari, Saima Zafar, Stephanie Booth, Gerard H Jansen, Aušrinė Areškevičiūtė, Eva Løbner Lund, Katie Glisic, Piero Parchi, Peter Hermann, Inga Zerr, Brian S Appleby, John Collinge, Simon Mead

Subject Terms: 3. Good health