Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions

Συγγραφείς: Isabel Fernandez-Carrasco, Javier Moral-Sanz, Sergey Kurdyukov, Èlia Obis, Lissy Maike Hartmann, Silvia Carina Magalhães Novais, Matthew A. Waller, Naomi McKinnon, Felicity Chung, Francisco Javier Salazar Castejón, Daniel P. Rainho, Zoltan Dekan, Thomas Kremsmayr, Bernhard Jandl, Kristina Eleršič Filipič, Reinald Pamplona, Mariona Jové, Manuel A. Fernandez-Rojo, Gregor Anderluh, Markus Muttenthaler, Paul F. A. Alewood, Jan Procházka, G. Gregory Neely, Evelyne Deplazes, Maria P. Ikonomopoulou

Πηγή: Cell Death Discovery, Vol 12, Iss 1 (2026)

Θεματικοί όροι: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2058-7716

Σύνδεσμος πρόσβασης: https://doaj.org/article/93df197ac65a44aba2c5120ce99399b9

The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions

Συγγραφείς: Isabel Fernandez-Carrasco, Javier Moral-Sanz, Sergey Kurdyukov, Èlia Obis, Lissy Maike Hartmann, Silvia Carina Magalhães Novais, Matthew A. Waller, Naomi McKinnon, Felicity Chung, Francisco Javier Salazar Castejón, Daniel P. Rainho, Zoltan Dekan, Thomas Kremsmayr, Bernhard Jandl, Kristina Eleršič Filipič, Reinald Pamplona, Mariona Jové, Manuel A. Fernandez-Rojo, Gregor Anderluh, Markus Muttenthaler, Paul F. A. Alewood, Jan Procházka, G. Gregory Neely, Evelyne Deplazes, Maria P. Ikonomopoulou

Πηγή: Cell Death Discovery, Vol 11, Iss 1, Pp 1-14 (2025)

Θεματικοί όροι: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2058-7716

Σύνδεσμος πρόσβασης: https://doaj.org/article/7af72380df51497d912d4ebcd5024d41

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension of the new-born and premature death

Συγγραφείς: Javier Moral-Sanz, Sophronia A. Lewis, Sandy MacMillan, Marco Meloni, Heather McClafferty, Benoit Viollet, Marc Foretz, Jorge del-Pozo, A. Mark Evans

Πηγή: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Θεματικοί όροι: Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2041-1723

Σύνδεσμος πρόσβασης: https://doaj.org/article/3376d21907c9443c9accb7061aa04379

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling

Συγγραφείς: Javier Moral-Sanz, Isabel Fernández-Carrasco, Valentina Ramponi, Amanda Garrido, Izhar Karbat, Pablo Cabezas-Sainz, Esperanza Rivera-de-Torre, Osama Elsallabi, Roberto Martín-Hernández, José L. López-Aceituno, Nathan L. Price, Laura Sanchez, Gonzalo Colmenarejo, Álvaro Martínez-del-Pozo, Irina Vetter, Angel Cogolludo, Francisco Perez-Vizcaino, Jorge Del-Pozo, Eitan Reuveny, Manuel A. Fernández-Rojo, Paul D. Robbins, Rafael de Cabo, Manuel Serrano, Maria P. Ikonomopoulou

Πηγή: Nat Aging
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernández-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling', Nature Aging, vol. 6, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernandez-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodelling', Nature Aging, vol. 6, no. 2, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-Del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernández-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling', Nature Aging, vol. 6, no. 2, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w

Θεματικοί όροι: Calcium/metabolism, Transport, 32 Biomedical and Clinical Sciences, Cellular Senescence/drug effects, Lipid Metabolism/drug effects, Article, Exposure, Mice, Software News, Cell Line, Tumor, 3211 Oncology and carcinogenesis, Animals, Humans, name=SDG 3 - Good Health and Well-being, Cellular Senescence, Immunotoxin, Volume, Apoptosis/drug effects, Monoclonal-Antibody, Channel, Neoplasms/drug therapy, 3204 Immunology, Senotherapeutics/pharmacology, Sticholysin I, Lipidomics, Mechanism, Antineoplastic Agents/pharmacology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41526742
https://espace.library.uq.edu.au/view/UQ:cda843f
https://api.library.uq.edu.au/view/UQ:cda843f

ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations

Συγγραφείς: Javier Moral-Sanz, Manuel A. Fernandez-Rojo, Jeremy Potriquet, Pamela Mukhopadhyay, Andreas Brust, Patrick Wilhelm, Taylor B. Smallwood, Richard J. Clark, Bryan G. Fry, Paul F. Alewood, Nicola Waddell, John J. Miles, Jason P. Mulvenna, Maria P. Ikonomopoulou

Πηγή: Toxins, Vol 13, Iss 2, p 146 (2021)

Θεματικοί όροι: melanoma BRAF mutation, cancer, combination-therapies, venom-peptide, octopus-peptide, Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://www.mdpi.com/2072-6651/13/2/146; https://doaj.org/toc/2072-6651

Σύνδεσμος πρόσβασης: https://doaj.org/article/d572031b4c944e80bb5752ab41c73b67

The flavonoid quercetin reverses pulmonary hypertension in rats.

Συγγραφείς: Daniel Morales-Cano, Carmen Menendez, Enrique Moreno, Javier Moral-Sanz, Bianca Barreira, Pilar Galindo, Rachele Pandolfi, Rosario Jimenez, Laura Moreno, Angel Cogolludo, Juan Duarte, Francisco Perez-Vizcaino

Πηγή: PLoS ONE, Vol 9, Iss 12, p e114492 (2014)

Θεματικοί όροι: Medicine, Science

Περιγραφή αρχείου: electronic resource

Relation: http://europepmc.org/articles/PMC4252144?pdf=render; https://doaj.org/toc/1932-6203

Σύνδεσμος πρόσβασης: https://doaj.org/article/0f7705e81ba24c4c8042019b8ee0b5fd

The structural conformation of the tachykinin domain drives the anti‐tumoural activity of an octopus peptide in melanoma BRAFV600E

Συγγραφείς: Javier Moral‐Sanz, Manuel A. Fernandez‐Rojo, Gonzalo Colmenarejo, Sergey Kurdyukov, Andreas Brust, Lotten Ragnarsson, Åsa Andersson, Sabela F. Vila, Pablo Cabezas‐Sainz, Patrick Wilhelm, Ana Vela‐Sebastián, Isabel Fernández‐Carrasco, Yanni K. Y. Chin, Yaiza López‐Mancheño, Taylor B. Smallwood, Richard J. Clark, Bryan G. Fry, Glenn F. King, Grant A. Ramm, Paul F. Alewood, Richard J. Lewis, Jason P. Mulvenna, Glen M. Boyle, Laura E. Sanchez, G. Gregory Neely, John J. Miles, Maria P. Ikonomopoulou

Πηγή: British Journal of Pharmacology. 179:4878-4896

Θεματικοί όροι: Pharmacology, Proto-Oncogene Proteins B-raf, 0301 basic medicine, 0303 health sciences, Octopodiformes, Antineoplastic Agents, 3. Good health, Mice, 03 medical and health sciences, 3004 Pharmacology, 0302 clinical medicine, Adenosine Triphosphate, Cell Line, Tumor, Tachykinins, Mutation, Animals, Humans, Calcium, RNA, Messenger, Peptides, Reactive Oxygen Species, Melanoma, Zebrafish

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35818835
https://api.library.uq.edu.au/view/UQ:b84c9d0/UQb84c9d0_OA.pdf
https://api.library.uq.edu.au/view/UQ:b84c9d0/thumbnail_UQb84c9d0_OA_t.jpg
https://api.library.uq.edu.au/view/UQ:b84c9d0
https://espace.library.uq.edu.au/view/UQ:b84c9d0
https://espace.library.uq.edu.au/view/UQ:b84c9d0/thumbnail_UQb84c9d0_OA_t.jpg
https://espace.library.uq.edu.au/view/UQ:b84c9d0/UQb84c9d0_OA.pdf

Activation of Kv7 channels as a novel mechanism for NO/cGMP‐induced pulmonary vasodilation

Συγγραφείς: Gema Mondéjar‐Parreño, Javier Moral‐Sanz, Bianca Barreira, Alicia De la Cruz, Teresa Gonzalez, Maria Callejo, Sergio Esquivel‐Ruiz, Daniel Morales‐Cano, Laura Moreno, Carmen Valenzuela, Francisco Perez‐Vizcaino, Angel Cogolludo

Συνεισφορές: Comunidad de Madrid, Universidad Complutense de Madrid, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), European Commission, Morales‐Cano, Daniel [0000-0002-1692-4633], Cogolludo, Angel [0000-0002-1382-1698], Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]

Πηγή: Digital.CSIC. Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
instname

Θεματικοί όροι: Male, Nitroprusside, 0301 basic medicine, 0303 health sciences, KCNQ Potassium Channels, Vasodilator Agents, Myocytes, Smooth Muscle, Pulmonary Artery, Nitric Oxide, 3. Good health, Vasodilation, Kv1.5 Potassium Channel, 03 medical and health sciences, Hydrazines, COS Cells, Chlorocebus aethiops, Animals, Nitric Oxide Donors, Rats, Wistar, Cyclic GMP

Σύνδεσμος πρόσβασης: https://bpspubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bph.14662
https://pubmed.ncbi.nlm.nih.gov/30883701
http://hdl.handle.net/10261/188671

AMPK deficiency in smooth muscles causes persistent pulmonary hypertension after birth and premature death

Συγγραφείς: Javier Moral-Sanz, Sophronia Lewis, Sandy MacMillan, Marco Meloni, Marc Foretz, Jorge del-Pozo, Heather McClaffterty, Benoit Viollet, A. Evans

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

Activation of PPARβ/δ prevents hyperglycaemia-induced impairment of Kv7 channels and cAMP-mediated relaxation in rat coronary arteries

Συγγραφείς: Daniel, Morales-Cano, Laura, Moreno, Bianca, Barreira, Ana M, Briones, Rachele, Pandolfi, Javier, Moral-Sanz, Maria, Callejo, Gema, Mondejar-Parreño, Julio, Cortijo, Mercedes, Salaices, Juan, Duarte, Francisco, Perez-Vizcaino, Angel, Cogolludo

Πηγή: Clinical Science. 130:1823-1836

Θεματικοί όροι: Male, 0301 basic medicine, 0303 health sciences, Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Protein Serine-Threonine Kinases, Coronary Vessels, Diabetes Mellitus, Experimental, Rats, Vasodilation, Thiazoles, 03 medical and health sciences, Phenols, Hyperglycemia, KCNQ1 Potassium Channel, Cyclic AMP, Animals, Humans, PPAR delta, Sulfhydryl Compounds, Rats, Wistar, Reactive Oxygen Species, PPAR-beta

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/27413020

Pulmonary Vascular Function in Insulin Resistance and Diabetes

Συγγραφείς: Javier, Moral-Sanz, Laura, Moreno, Angel, Cogolludo, Francisco, Perez-Vizcaino

Πηγή: Current Vascular Pharmacology. 12:473-482

Θεματικοί όροι: Potassium Channels, Hypertension, Pulmonary, Hemodynamics, 1. No poverty, Pulmonary Artery, Respiratory Function Tests, 3. Good health, 03 medical and health sciences, Diabetes Mellitus, Type 1, 0302 clinical medicine, Diabetes Mellitus, Type 2, Humans, Vascular Resistance, Insulin Resistance

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/24846236

Type 1 Diabetes-Induced Hyper-Responsiveness to 5-Hydroxytryptamine in Rat Pulmonary Arteries via Oxidative Stress and Induction of Cyclooxygenase-2

Συγγραφείς: Jose G, Lopez-Lopez, Javier, Moral-Sanz, Giovanna, Frazziano, Maria J, Gomez-Villalobos, Laura, Moreno, Carmen, Menendez, Jorge, Flores-Hernandez, Jose A, Lorente, Angel, Cogolludo, Francisco, Perez-Vizcaino

Πηγή: The Journal of Pharmacology and Experimental Therapeutics. 338:400-407

Θεματικοί όροι: Male, Serotonin, Pulmonary Artery, Bone Morphogenetic Protein Receptors, Type II, Rats, 3. Good health, Rats, Sprague-Dawley, Oxidative Stress, 03 medical and health sciences, Diabetes Mellitus, Type 1, 0302 clinical medicine, Cyclooxygenase 2, Vasoconstriction, Enzyme Induction, Animals, Endothelium, Vascular

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/21521772

Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries

Συγγραφείς: Javier, Moral-Sanz, Teresa, Gonzalez, Carmen, Menendez, Miren, David, Laura, Moreno, Alvaro, Macias, Julio, Cortijo, Carmen, Valenzuela, Francisco, Perez-Vizcaino, Angel, Cogolludo

Πηγή: American Journal of Physiology-Cell Physiology. 301:C186-C194

Θεματικοί όροι: Male, 0301 basic medicine, Aniline Compounds, Patch-Clamp Techniques, Phosphines, Myocytes, Smooth Muscle, Receptors, Thromboxane, Pulmonary Artery, Ceramides, Benzylidene Compounds, Muscle, Smooth, Vascular, Membrane Potentials, Rats, 3. Good health, 03 medical and health sciences, HEK293 Cells, Potassium Channels, Voltage-Gated, 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid, Animals, Humans, Rats, Wistar, Peptides, Protein Kinase C

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/21490312

Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels

Συγγραφείς: Álvaro Macías, Cristina Moreno, Javier Moral-Sanz, Ángel Cogolludo, Miren David, Matteo Alemanni, Francisco Pérez-Vizcaíno, Antonio Zaza, Carmen Valenzuela, Teresa González

Πηγή: Journal of Molecular and Cellular Cardiology. 49:984-992

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

Maturation of O2sensing and signaling in the chicken ductus arteriosus

Συγγραφείς: Angel L, Cogolludo, Javier, Moral-Sanz, Saskia, van der Sterren, Giovanna, Frazziano, Anne N H, van Cleef, Carmen, Menéndez, Bea, Zoer, Enrique, Moreno, Angela, Roman, Francisco, Pérez-Vizcaino, Eduardo, Villamor

Πηγή: American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L619-L630

Θεματικοί όροι: 0301 basic medicine, rho-Associated Kinases, 0303 health sciences, Calcium Channels, L-Type, Reverse Transcriptase Polymerase Chain Reaction, Blotting, Western, Chick Embryo, Ductus Arteriosus, Hydrogen Peroxide, Oxidants, Electrophysiology, Oxygen, Electron Transport Complex III, 03 medical and health sciences, Potassium Channels, Voltage-Gated, Animals, RNA, Messenger, Reactive Oxygen Species, Aorta

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/19617310

Diabetes induces pulmonary artery endothelial dysfunction by NADPH oxidase induction

Συγγραφείς: Jose G, Lopez-Lopez, Javier, Moral-Sanz, Giovanna, Frazziano, Maria J, Gomez-Villalobos, Jorge, Flores-Hernandez, Eduardo, Monjaraz, Angel, Cogolludo, Francisco, Perez-Vizcaino

Πηγή: American Journal of Physiology-Lung Cellular and Molecular Physiology. 295:L727-L732

Θεματικοί όροι: Male, 2. Zero hunger, 0301 basic medicine, NADPH Oxidases, In Vitro Techniques, Pulmonary Artery, Nitric Oxide, Acetylcholine, Rats, 3. Good health, Rats, Sprague-Dawley, Vasodilation, 03 medical and health sciences, NG-Nitroarginine Methyl Ester, 0302 clinical medicine, Superoxides, Enzyme Induction, Diabetes Mellitus, Animals, Endothelium

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/18723759

Modulation of the LKB1-AMPK Signalling Pathway Underpins Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension

Συγγραφείς: A Mark, Evans, Sophronia A, Lewis, Oluseye A, Ogunbayo, Javier, Moral-Sanz

Πηγή: Advances in Experimental Medicine and Biology ISBN: 9783319184395

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Hypertension, Pulmonary, AMP-Activated Protein Kinases, Protein Serine-Threonine Kinases, Pulmonary Artery, Cell Hypoxia, Mitochondria, 3. Good health, 03 medical and health sciences, AMP-Activated Protein Kinase Kinases, Vasoconstriction, Animals, Humans, Signal Transduction

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/26303471

AMP‐activated Protein Kinase is Necessary for Cardiorespiratory Adjustments during Hypoxia

Συγγραφείς: Sophronia Lewis, Javier Moral‐Sanz, A Evans

Πηγή: The FASEB Journal. 29

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 13. Climate action, 7. Clean energy, 3. Good health

Acid sphingomyelinase, a novel pathway for pulmonary vasoconstriction. Activation by apoptotic T cell microparticles and Fas ligand

Συγγραφείς: Javier Javier Moral-Sanz, Daniel Morales-Cano, Bianca Barreira, Raffaella Soleti, Laura Moreno, Angel Cogolludo, Ramaroson Andriantsitohaina, Carmen Martinez, Francisco Perez-Vizcaino

Πηγή: European Respiratory Journal. 44:P313

The flavonoid quercetin reverses monocrotaline-induced pulmonary hypertension

Συγγραφείς: Daniel Morales-Cano, Carmen Menendez, Javier Moral-Sanz, Bianca Barreira, Rosario Jimenez, Laura Moreno, Angel Cogolludo, Julio Cortijo, Juan Duarte, Franciso Perez-Vizcaino

Πηγή: European Respiratory Journal. 44:P2365