Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine‐induced adverse effects in an acute lymphoblastic leukemia patient‐derived xenograft model

Συγγραφείς: Hana Starobova, Hannah McCalmont, Svetlana Shatunova, Nicolette Tay, Christopher M. Smith, Avril Robertson, Ingrid Winkler, Richard B. Lock, Irina Vetter

Πηγή: HemaSphere, Vol 9, Iss 3, Pp n/a-n/a (2025)

Θεματικοί όροι: Diseases of the blood and blood-forming organs, RC633-647.5

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2572-9241

Σύνδεσμος πρόσβασης: https://doaj.org/article/15008f4316c345538ea5842be89bb681

How to differentiate induced pluripotent stem cells into sensory neurons for disease modelling: a functional assessment

Συγγραφείς: Anil Kumar Kalia, Corinna Rösseler, Rafael Granja-Vazquez, Ayesha Ahmad, Joseph J. Pancrazio, Anika Neureiter, Mei Zhang, Daniel Sauter, Irina Vetter, Asa Andersson, Gregory Dussor, Theodore J. Price, Benedict J. Kolber, Vincent Truong, Patrick Walsh, Angelika Lampert

Πηγή: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-28 (2024)

Θεματικοί όροι: Sensory neurons, Disease modelling, Human induced pluripotent stem cells, Sodium channel, Pain, Medicine (General), R5-920, Biochemistry, QD415-436

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1757-6512

Σύνδεσμος πρόσβασης: https://doaj.org/article/64b0342489ca43859d062555e3986dc2

o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

Συγγραφείς: Md. Habibur Rahaman, Sara J. Thygesen, Michael J. Maxwell, Hyoyoung Kim, Prerna Mudai, Jeffrey D. Nanson, Xinying Jia, Parimala R. Vajjhala, Andrew Hedger, Irina Vetter, Thomas Haselhorst, Avril A. B. Robertson, Brian Dymock, Thomas Ve, Mehdi Mobli, Katryn J. Stacey, Bostjan Kobe

Πηγή: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

Θεματικοί όροι: Covalent modification, o-vanillin, MyD88 adaptor-like (MAL), nuclear magnetic resonance (NMR), Toll-like receptor (TLR), Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP), Therapeutics. Pharmacology, RM1-950

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374

Σύνδεσμος πρόσβασης: https://doaj.org/article/dcf8b7e19c924597be45dfa99851bf23

Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs

Συγγραφείς: Christina N. Zdenek, Fernanda C. Cardoso, Samuel D. Robinson, Raine S. Mercedes, Enriko R. Raidjõe, María José Hernandez-Vargas, Jiayi Jin, Gerardo Corzo, Irina Vetter, Glenn F. King, Bryan G. Fry, Andrew A. Walker

Πηγή: iScience, Vol 27, Iss 9, Pp 110723- (2024)

Θεματικοί όροι: Pharmacology, Entomology, Biochemistry, Evolutionary biology, Science

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004224019485; https://doaj.org/toc/2589-0042

Σύνδεσμος πρόσβασης: https://doaj.org/article/c7ebb8f5f71349499699a1a3ac14234a

Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom

Συγγραφείς: Priscilla Galante, Gabriel A. A. Campos, Jacqueline C. G. Moser, Danubia B. Martins, Marcia P. dos Santos Cabrera, Marisa Rangel, Luiza C. Coelho, Karina S. Simon, Veronica M. Amado, Jessica de A. I. Muller, Johannes Koehbach, Rink-Jan Lohman, Peter J. Cabot, Irina Vetter, David J. Craik, Monica C. Toffoli-Kadri, Victoria Monge-Fuentes, Jair T. Goulart, Elisabeth F. Schwartz, Luciano P. Silva, Anamelia L. Bocca, Márcia R. Mortari

Πηγή: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Θεματικοί όροι: Medicine, Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2045-2322

Σύνδεσμος πρόσβασης: https://doaj.org/article/b67d9db1535243309705120d264359b7

Ant venoms contain vertebrate-selective pain-causing sodium channel toxins

Συγγραφείς: Samuel D. Robinson, Jennifer R. Deuis, Axel Touchard, Angelo Keramidas, Alexander Mueller, Christina I. Schroeder, Valentine Barassé, Andrew A. Walker, Nina Brinkwirth, Sina Jami, Elsa Bonnafé, Michel Treilhou, Eivind A. B. Undheim, Justin O. Schmidt, Glenn F. King, Irina Vetter

Πηγή: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Θεματικοί όροι: Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2041-1723

Σύνδεσμος πρόσβασης: https://doaj.org/article/06020d0862264dda9a11dae6073fc211

Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

Συγγραφείς: Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter

Πηγή: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Θεματικοί όροι: Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2041-1723

Σύνδεσμος πρόσβασης: https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

Συγγραφείς: Michael J. Maxwell, Chris Thekkedam, Cedric Lamboley, Yanni K.-Y. Chin, Theo Crawford, Jennifer J. Smith, Junyu Liu, Xinying Jia, Irina Vetter, Derek R. Laver, Bradley S. Launikonis, Angela Dulhunty, Eivind A. B. Undheim, Mehdi Mobli

Πηγή: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Θεματικοί όροι: Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2041-1723

Σύνδεσμος πρόσβασης: https://doaj.org/article/ecfef30c1c5e4dc1ab651ec6f5d81576

Intra-colony venom diversity contributes to maintaining eusociality in a cooperatively breeding ant

Συγγραφείς: Samuel D. Robinson, Vanessa Schendel, Christina I. Schroeder, Sarah Moen, Alexander Mueller, Andrew A. Walker, Naomi McKinnon, G. Gregory Neely, Irina Vetter, Glenn F. King, Eivind A. B. Undheim

Πηγή: BMC Biology, Vol 21, Iss 1, Pp 1-19 (2023)

Θεματικοί όροι: Formicidae, Kin selection, Group selection, Eusocial, Peptide, Toxin, Biology (General), QH301-705.5

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1741-7007

Σύνδεσμος πρόσβασης: https://doaj.org/article/d7dcdb11b76c4cd2a50d33482f7f16f4

Venom composition and pain-causing toxins of the Australian great carpenter bee Xylocopa aruana

Συγγραφείς: Naiqi Shi, Tibor G. Szanto, Jia He, Christina I. Schroeder, Andrew A. Walker, Jennifer R. Deuis, Irina Vetter, György Panyi, Glenn F. King, Samuel D. Robinson

Πηγή: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Θεματικοί όροι: Medicine, Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2045-2322

Σύνδεσμος πρόσβασης: https://doaj.org/article/a7b944fd6ac7465eb9bd2a5495f1a26e

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Συγγραφείς: Yue Wu, Zhenling Cui, Yen-Hua Huang, Simon J. de Veer, Andrey V. Aralov, Zhong Guo, Shayli V. Moradi, Alexandra O. Hinton, Jennifer R. Deuis, Shaodong Guo, Kai-En Chen, Brett M. Collins, Irina Vetter, Volker Herzig, Alun Jones, Matthew A. Cooper, Glenn F. King, David J. Craik, Kirill Alexandrov, Sergey Mureev

Πηγή: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Θεματικοί όροι: Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2041-1723

Σύνδεσμος πρόσβασης: https://doaj.org/article/4f078ffc82bf47b0b496a47fa5dcdbdc

Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients

Συγγραφείς: Nicolette Tay, E-Liisa Laakso, Daniel Schweitzer, Raelene Endersby, Irina Vetter, Hana Starobova

Πηγή: Frontiers in Molecular Biosciences, Vol 9 (2022)

Θεματικοί όροι: chemotherapy-induced peripheral neuropathy, pediatric cancer patients and survivors, neuroinflammation, pharmacological and non-pharmacological treatment strategies, CIPN mechanisms, Biology (General), QH301-705.5

Περιγραφή αρχείου: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2022.1015746/full; https://doaj.org/toc/2296-889X

Σύνδεσμος πρόσβασης: https://doaj.org/article/dc6b2867ac5e4c5f947cd1b559934f44

Voltage-Gated Sodium Channel Inhibition by µ-Conotoxins

Συγγραφείς: Kirsten L. McMahon, Irina Vetter, Christina I. Schroeder

Πηγή: Toxins, Vol 16, Iss 1, p 55 (2024)

Θεματικοί όροι: µ-conotoxin, peptide, structure–activity relationships, venom peptide, disulfide-rich peptide, voltage-gated sodium channels, Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://www.mdpi.com/2072-6651/16/1/55; https://doaj.org/toc/2072-6651

Σύνδεσμος πρόσβασης: https://doaj.org/article/26cd559e85ab4274bb8dcdf46263cf5d

The Tarantula Venom Peptide Eo1a Binds to the Domain II S3-S4 Extracellular Loop of Voltage-Gated Sodium Channel NaV1.8 to Enhance Activation

Συγγραφείς: Jennifer R. Deuis, Lotten Ragnarsson, Samuel D. Robinson, Zoltan Dekan, Lerena Chan, Ai-Hua Jin, Poanna Tran, Kirsten L. McMahon, Shengnan Li, John N. Wood, James J. Cox, Glenn F. King, Volker Herzig, Irina Vetter

Πηγή: Frontiers in Pharmacology, Vol 12 (2022)

Θεματικοί όροι: voltage-gated sodium channel, Nav1.8, pain, peptide, spider, Therapeutics. Pharmacology, RM1-950

Περιγραφή αρχείου: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.789570/full; https://doaj.org/toc/1663-9812

Σύνδεσμος πρόσβασης: https://doaj.org/article/bd63805c3cda45b888b37022a4d2135f

A pain-causing and paralytic ant venom glycopeptide

Συγγραφείς: Samuel D. Robinson, Lucas Kambanis, Daniel Clayton, Hannes Hinneburg, Leo Corcilius, Alexander Mueller, Andrew A. Walker, Angelo Keramidas, Sameer S. Kulkarni, Alun Jones, Irina Vetter, Morten Thaysen-Andersen, Richard J. Payne, Glenn F. King, Eivind A.B. Undheim

Πηγή: iScience, Vol 24, Iss 10, Pp 103175- (2021)

Θεματικοί όροι: Natural product chemistry, Biomolecules, Neuroscience, Science

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221011433; https://doaj.org/toc/2589-0042

Σύνδεσμος πρόσβασης: https://doaj.org/article/78baef6776294d269907493bbcce2af2

Two Novel Mosquitocidal Peptides Isolated from the Venom of the Bahia Scarlet Tarantula (Lasiodora klugi)

Συγγραφείς: Jamila Ahmed, Andrew A. Walker, Hugo D. Perdomo, Shaodong Guo, Samantha A. Nixon, Irina Vetter, Hilary I. Okoh, Dalhatu M. Shehu, Mohammed N. Shuaibu, Iliya S. Ndams, Glenn F. King, Volker Herzig

Πηγή: Toxins, Vol 15, Iss 7, p 418 (2023)

Θεματικοί όροι: Lasiodora klugi, insecticidal toxin, Aedes aegypti, disulfide-directed β-hairpin, inhibitor cystine knot, Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://www.mdpi.com/2072-6651/15/7/418; https://doaj.org/toc/2072-6651

Σύνδεσμος πρόσβασης: https://doaj.org/article/edc65baed3574cc8b692912fa938c9ef

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling

Συγγραφείς: Javier Moral-Sanz, Isabel Fernández-Carrasco, Valentina Ramponi, Amanda Garrido, Izhar Karbat, Pablo Cabezas-Sainz, Esperanza Rivera-de-Torre, Osama Elsallabi, Roberto Martín-Hernández, José L. López-Aceituno, Nathan L. Price, Laura Sanchez, Gonzalo Colmenarejo, Álvaro Martínez-del-Pozo, Irina Vetter, Angel Cogolludo, Francisco Perez-Vizcaino, Jorge Del-Pozo, Eitan Reuveny, Manuel A. Fernández-Rojo, Paul D. Robbins, Rafael de Cabo, Manuel Serrano, Maria P. Ikonomopoulou

Πηγή: Nat Aging
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernández-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling', Nature Aging, vol. 6, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernandez-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodelling', Nature Aging, vol. 6, no. 2, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w
Moral-Sanz, J, Fernández-Carrasco, I, Ramponi, V, Garrido, A, Karbat, I, Cabezas-Sainz, P, Rivera-de-Torre, E, Elsallabi, O, Martín-Hernández, R, López-Aceituno, J L, Price, N L, Sanchez, L, Colmenarejo, G, Martínez-Del-Pozo, Á, Vetter, I, Cogolludo, A, Perez-Vizcaino, F, Del-Pozo, J, Reuveny, E, Fernández-Rojo, M A, Robbins, P D, de Cabo, R, Serrano, M & Ikonomopoulou, M P 2026, 'Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling', Nature Aging, vol. 6, no. 2, pp. 349-367. https://doi.org/10.1038/s43587-025-01030-w

Θεματικοί όροι: Calcium/metabolism, Transport, 32 Biomedical and Clinical Sciences, Cellular Senescence/drug effects, Lipid Metabolism/drug effects, Article, Exposure, Mice, Software News, Cell Line, Tumor, 3211 Oncology and carcinogenesis, Animals, Humans, name=SDG 3 - Good Health and Well-being, Cellular Senescence, Immunotoxin, Volume, Apoptosis/drug effects, Monoclonal-Antibody, Channel, Neoplasms/drug therapy, 3204 Immunology, Senotherapeutics/pharmacology, Sticholysin I, Lipidomics, Mechanism, Antineoplastic Agents/pharmacology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41526742
https://espace.library.uq.edu.au/view/UQ:cda843f
https://api.library.uq.edu.au/view/UQ:cda843f

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7

Συγγραφείς: Kirsten L. McMahon, Hue N. T. Tran, Jennifer R. Deuis, David J. Craik, Irina Vetter, Christina I. Schroeder

Πηγή: Toxins, Vol 14, Iss 9, p 600 (2022)

Θεματικοί όροι: µ-conotoxins, voltage-gated sodium channels, structure-activity relationships, disulfide-rich peptides, Cys frameworks, Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://www.mdpi.com/2072-6651/14/9/600; https://doaj.org/toc/2072-6651

Σύνδεσμος πρόσβασης: https://doaj.org/article/284b70228f8842f0997a55259521fe7b

The NLRP3 Inflammasome: Role and Therapeutic Potential in Pain Treatment

Συγγραφείς: Hana Starobova, Evelyn Israel Nadar, Irina Vetter

Πηγή: Frontiers in Physiology, Vol 11 (2020)

Θεματικοί όροι: NOD, LRR and PYD domains-containing protein 3, neuro-inflammation, MCC950, interleukin-1β, sensory neurons, Physiology, QP1-981

Περιγραφή αρχείου: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphys.2020.01016/full; https://doaj.org/toc/1664-042X

Σύνδεσμος πρόσβασης: https://doaj.org/article/a5641b4c21a84089b2815a1a92c5db3b

NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome.

Συγγραφείς: Wout J Weuring, Sakshi Singh, Linda Volkers, Martin B Rook, Ruben H van 't Slot, Marjolein Bosma, Marco Inserra, Irina Vetter, Nanda M Verhoeven-Duif, Kees P J Braun, Mirko Rivara, Bobby P C Koeleman

Πηγή: PLoS ONE, Vol 15, Iss 3, p e0219106 (2020)

Θεματικοί όροι: Medicine, Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1932-6203

Σύνδεσμος πρόσβασης: https://doaj.org/article/6bee8c3f2c6649e9a69da93d49666e56