Decoupling T cell cytotoxicity: a CCL21+ICAM1-based synthetic immune niche enhances tumor elimination by accelerating lytic hit delivery.

Συγγραφείς: Gupta MK; Center for Interdisciplinary Digital Sciences, Department Information Services and High Performance Computing, TUD Dresden University of Technology, Dresden, Germany. manishsvm30@gmail.com., Zoabi R; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Yado S; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel., Starruß J; Center for Interdisciplinary Digital Sciences, Department Information Services and High Performance Computing, TUD Dresden University of Technology, Dresden, Germany., Geiger B; Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel. benny.geiger@weizmann.ac.il., Hatzikirou H; Center for Interdisciplinary Digital Sciences, Department Information Services and High Performance Computing, TUD Dresden University of Technology, Dresden, Germany.; Department of Mathematics, Khalifa University, Abu Dhabi, UAE.; Health and Life Sciences, European University Cyprus at Frankfurt, Frankfurt, Germany.

Πηγή: BMC cancer [BMC Cancer] 2026 Oct 15; Vol. 26 (1). Date of Electronic Publication: 2026 Oct 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Chemokine CCL21*/immunology , Chemokine CCL21*/metabolism , Intercellular Adhesion Molecule-1*/immunology , Intercellular Adhesion Molecule-1*/metabolism , Melanoma, Experimental*/immunology , Melanoma, Experimental*/therapy , Melanoma, Experimental*/pathology , Immunotherapy, Adoptive*/methods , T-Lymphocytes, Cytotoxic*/immunology , CD8-Positive T-Lymphocytes*/immunology , Cytotoxicity, Immunologic*, Animals ; Mice ; Cell Line, Tumor ; Humans

Setmelanotide alleviates diabetes-associated cognitive impairment by interrupting the binding of ICAM-1 and JIP1 in endothelial cells of the blood-brain barrier.

Συγγραφείς: Wu SD; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Wang X; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China; National Demonstration Center for Experimental Basic Medical Science Education (Xuzhou Medical University)., Zhou YM; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Hu B; Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Wang KY; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Yan CJ; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Zhu HY; The Graduate School, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Li H; Jiangsu Key Laboratory of Brain Disease and Bioinformation, Research Center for Biochemistry and Molecular Biology, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China., Wang XC; Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China., Wang HP; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China., Cheng AF; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Taipa, Macao, SAR, 999078, China., Zhu ZS; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address: victorzhu2013@xzhmu.edu.cn., Ying CJ; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China; Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221002, China.. Electronic address: ycj321651@163.com., Zhou XY; Jiangsu Engineering Center for Precision Diagnosis and Treatment Research of Polygenic Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, 221004, China. Electronic address: zhouxiaoyan0201@xzhmu.edu.cn.

Πηγή: Metabolism: clinical and experimental [Metabolism] 2026 Oct; Vol. 183, pp. 156712. Date of Electronic Publication: 2026 Jul 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Blood-Brain Barrier*/drug effects , Blood-Brain Barrier*/metabolism , Intercellular Adhesion Molecule-1*/metabolism , Endothelial Cells*/metabolism , Endothelial Cells*/drug effects , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/metabolism , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/pharmacology, Protein Binding/drug effects ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL

Tocotrienol as a multi-target inhibitor of ICAM-1, VCAM-1, and E-selectin: Comparison using AutoDock and GNINA docking with molecular dynamics simulation.

Συγγραφείς: Abdah HW; Cardiovascular Advancement and Research Excellence Institute (CARE Institute), Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus, Sungai Buloh, Selangor 47000, Malaysia., Jusoh SA; Department of Life Science, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Puncak Alam Selangor Campus, Puncak Alam, Selangor 42300, Malaysia., Dzulkharnien NSF; Cardiovascular Advancement and Research Excellence Institute (CARE Institute), Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus, Sungai Buloh, Selangor 47000, Malaysia., Hanafi NI; Cardiovascular Advancement and Research Excellence Institute (CARE Institute), Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus, Sungai Buloh, Selangor 47000, Malaysia., Mohd Nasir AM; Department of Life Science, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Puncak Alam Selangor Campus, Puncak Alam, Selangor 42300, Malaysia., Abd Muid S; Cardiovascular Advancement and Research Excellence Institute (CARE Institute), Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus, Sungai Buloh, Selangor 47000, Malaysia; Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus, Sungai Buloh, Selangor 47000, Malaysia., Mohd Kasim NA; Cardiovascular Advancement and Research Excellence Institute (CARE Institute), Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus, Sungai Buloh, Selangor 47000, Malaysia; Department of Pathology, Faculty of Medicine, Universiti Teknologi MARA (UiTM) Sungai Buloh Selangor Campus, Sungai Buloh, Selangor 47000, Malaysia. Electronic address: noor202@uitm.edu.my.

Πηγή: Computational biology and chemistry [Comput Biol Chem] 2026 Oct; Vol. 124 (Pt 1), pp. 109136. Date of Electronic Publication: 2026 May 27.

Τύπος έκδοσης: Journal Article; Comparative Study

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-928X (Electronic) Linking ISSN: 14769271 NLM ISO Abbreviation: Comput Biol Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/chemistry , Tocotrienols*/chemistry , Tocotrienols*/pharmacology , E-Selectin*/antagonists & inhibitors , E-Selectin*/metabolism , E-Selectin*/chemistry , Vascular Cell Adhesion Molecule-1*/antagonists & inhibitors , Vascular Cell Adhesion Molecule-1*/metabolism , Vascular Cell Adhesion Molecule-1*/chemistry , Molecular Dynamics Simulation* , Molecular Docking Simulation*, Humans

ICAM-1 Hypomethylation Predicts Poor Prognosis in Patients With Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

Συγγραφείς: Xu MM; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China., Yao YX; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China., Lyu H; Department of Serve Liver Disease, Shandong Public Health Clinical Center of Shandong University, Jinan, Shandong, China., Qian Y; Department of Infectious Diseases, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China., Tian ZZ; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China., Fan YC; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China.; Hepatology Institute of Shandong University, Jinan, Shandong, China., Wang K; Department of Hepatology, Qilu Hospital of Shandong University, Jinan, Shandong, China.; Hepatology Institute of Shandong University, Jinan, Shandong, China.

Πηγή: Journal of medical virology [J Med Virol] 2026 Sep; Vol. 98 (9), pp. e71118.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Acute-On-Chronic Liver Failure*/mortality , Acute-On-Chronic Liver Failure*/diagnosis , Acute-On-Chronic Liver Failure*/virology , Intercellular Adhesion Molecule-1*/genetics , Intercellular Adhesion Molecule-1*/blood , Hepatitis B, Chronic*/complications , DNA Methylation*, Humans ; Prognosis ; Female ; Male ; Adult ; Promoter Regions, Genetic ; Middle Aged ; Leukocytes, Mononuclear ; Hepatitis B virus ; RNA, Messenger

Aspirin mitigates sepsis-associated encephalopathy by modulating ICAM-1 and MMP-9 signaling: Evidence from clinical cohorts and mechanistic experiments.

Συγγραφείς: Cui Y; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China; School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China; Innovation Research Center for Sepsis and Multiple Organ Injury, Shandong University, Jinan, Shandong, China., Lu S; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China; Interdisciplinary Center, Shandong University, Jinan, Shandong, China., Lv K; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China., Zhang H; Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; NHC Key Lab of Health Economics and Policy Research, Shandong University, Jinan, Shandong, China., Pang M; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China; School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China., Wang H; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China; School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China., Tian X; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China; School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China., Chen H; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China., Qiu J; Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address: qiujihua@sdu.edu.cn., Wang H; Department of Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China; School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China. Electronic address: wanghao34@126.com.

Πηγή: Experimental neurology [Exp Neurol] 2026 Sep; Vol. 403, pp. 115813. Date of Electronic Publication: 2026 May 10.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Matrix Metalloproteinase 9*/metabolism , Sepsis-Associated Encephalopathy*/metabolism , Sepsis-Associated Encephalopathy*/drug therapy , Sepsis-Associated Encephalopathy*/prevention & control , Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/drug effects , Aspirin*/therapeutic use , Aspirin*/pharmacology , Signal Transduction*/drug effects , Anti-Inflammatory Agents, Non-Steroidal*/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal*/pharmacology, Hippocampus/metabolism ; Hippocampus/drug effects ; Animals ; Mice ; Humans ; Male ; Mice, Inbred C57BL

Bispecific nanobodies targeting Bet v 1 and ICAM-1 decrease respiratory epithelial penetration of Bet v 1.

Συγγραφείς: Zettl I; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Ellinger I; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Zghaebi M; Vienna Airway Lab, Department of Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Jance S; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Izewski V; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Drescher A; Cytiva Europe GmbH, Freiburg, Germany., Breiteneder H; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Röck M; Department of Organic Chemistry, University of Innsbruck, Innsbruck, Austria., Tollinger M; Department of Organic Chemistry, University of Innsbruck, Innsbruck, Austria., Eckl-Dorna J; Vienna Airway Lab, Department of Otolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria., Tillib SV; Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia., Flicker S; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Aug 17; Vol. 17, pp. 1864741. Date of Electronic Publication: 2026 Aug 17 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intercellular Adhesion Molecule-1*/immunology , Intercellular Adhesion Molecule-1*/metabolism , Antibodies, Bispecific*/immunology , Antibodies, Bispecific*/pharmacology , Antigens, Plant*/immunology , Antigens, Plant*/metabolism , Single-Domain Antibodies*/immunology , Single-Domain Antibodies*/pharmacology , Allergens*/immunology , Respiratory Mucosa*/immunology , Respiratory Mucosa*/metabolism, Epithelial Cells/immunology ; Epithelial Cells/metabolism ; Pollen/immunology ; Humans ; Cell Line

ICAM1high Neutrophils Sculpt Tumor Evolution and Metastasis Through Symbiotic Adhesion and Reverse Migration.

Συγγραφείς: Wu L; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Xu Z; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Wang J; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas., Liu F; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, Texas., Ding Y; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Gao Y; Department of Cancer Biology and Genetics, The Ohio State University College of Medicine, Columbus, Ohio.; The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Wang S; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, Texas., Liu J; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Chan HL; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, Texas.; Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas.; The Robert and Janice McNair Foundation MD/PhD Scholars, Baylor College of Medicine, Houston, Texas., Wu W; Advanced Technology Cores, Baylor College of Medicine, Houston, Texas., Wu YH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, Texas., Yu L; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Hao X; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Li X; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Edwards DG; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Sha C; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, Texas.; Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas., Lee TD; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Quantitative and Computational Biosciences Graduate Program, Baylor College of Medicine, Houston, Texas., Guan N; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, Texas., Aguirre S; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, Texas., Becerra-Dominguez L; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Immunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, Texas., Hoffman D; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, Texas., Chen X; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Rivas CH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Cancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, Texas., Yan XG; The Awty International School, Houston, Texas., Bado IL; Icahn School of Medicine at Mount Sinai , New York, New York.; Mount Sinai Tisch Cancer Center, New York, New York.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York., Zhang W; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas., Zhu Q; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas., Sreekumar A; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas., Satcher RL; Department of Orthopedic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zhang XH; Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas.

Πηγή: Cancer research [Cancer Res] 2026 Aug 14; Vol. 86 (16), pp. 4007-4027.

Τύπος έκδοσης: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Στοιχεία περιοδικού: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neutrophils*/metabolism , Neutrophils*/immunology , Neutrophils*/pathology , Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/metabolism , Triple Negative Breast Neoplasms*/genetics, Tumor Microenvironment/immunology ; Humans ; Animals ; Cell Adhesion ; Female ; Cell Movement ; Mice ; Neoplasm Metastasis ; Cell Line, Tumor

Wilms Tumor 1-associated Protein Promotes Sepsis-induced Disseminated Intravascular Coagulation by Stabilizing Intercellular Adhesion Molecule 1 Via N6-methyladenosine Modification.

Συγγραφείς: Jia X; Department of ICU, The Second Nanning People's Hospital, Guangxi Zhuang Autonomous Region, Nanning, 530000, China. Jiaxinju2025@126.com.; Department of ICU, The Second Nanning People's Hospital, No. 13, Tancun Road, Jiangnan District, Nanning, Guangxi Zhuang Autonomous Region, 530000, China. Jiaxinju2025@126.com., Su T; Department of ICU, The Second Nanning People's Hospital, Guangxi Zhuang Autonomous Region, Nanning, 530000, China., Liang H; Department of ICU, The Second Nanning People's Hospital, Guangxi Zhuang Autonomous Region, Nanning, 530000, China.

Πηγή: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2026 Aug; Vol. 40 (4), pp. 1271-1281. Date of Electronic Publication: 2025 Nov 25.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Sepsis*/complications , Sepsis*/metabolism , Sepsis*/genetics , Sepsis*/blood , Sepsis*/chemically induced , Disseminated Intravascular Coagulation*/genetics , Disseminated Intravascular Coagulation*/etiology , Disseminated Intravascular Coagulation*/metabolism , Disseminated Intravascular Coagulation*/blood , RNA Splicing Factors*/metabolism , RNA Splicing Factors*/genetics , Cell Cycle Proteins*/metabolism , Cell Cycle Proteins*/genetics , Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Adenosine*/analogs & derivatives , Adenosine*/metabolism , Blood Coagulation*, Human Umbilical Vein Endothelial Cells/metabolism ; Animals ; Humans ; Male ; Disease Models, Animal ; Rats, Sprague-Dawley ; Lipopolysaccharides ; RNA Methylation ; Rats

ICAM-1 targeting of nanocarriers in a human blood-brain-barrier-on-a-chip complements in vivo brain delivery observations.

Συγγραφείς: Vigo M; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Biomedicine Doctorate Program, University of Barcelona (UB), Barcelona, Spain., Palma-Florez S; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Biomedicine Doctorate Program, University of Barcelona (UB), Barcelona, Spain., Grimalt-Mirada R; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Placci M; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Biotechnology Doctorate Program, University of Barcelona (UB), Barcelona, Spain., Crespo A; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Giannotti MI; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER_BBN), Carlos III Health Institute, Madrid, Spain.; Department of Materials Science and Physical Chemistry and IQTC, University of Barcelona, Barcelona, Spain., Lagunas A; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER_BBN), Carlos III Health Institute, Madrid, Spain., Mir M; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER_BBN), Carlos III Health Institute, Madrid, Spain.; Department of Electronics and Biomedical Engineering, University of Barcelona, Barcelona, Spain., Samitier J; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Biomedical Research Networking Centre in Bioengineering, Biomaterials and Nanomedicine (CIBER_BBN), Carlos III Health Institute, Madrid, Spain.; Department of Electronics and Biomedical Engineering, University of Barcelona, Barcelona, Spain., Muro S; Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; Institute for Bioscience and Biotechnology Research (IBBR) & Department of Chemical and Biomolecular Engineering (ChemE), University of Marylan College Park, College Park, MD, USA.; Institution of Catalonia for Research and Advanced Studies (ICREA), Barcelona, Spain.

Πηγή: Journal of drug targeting [J Drug Target] 2026 Aug; Vol. 34 (7), pp. 1210-1223. Date of Electronic Publication: 2025 Dec 18.

Τύπος έκδοσης: Journal Article; Research Support, N.I.H., Extramural

Στοιχεία περιοδικού: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2330 (Electronic) Linking ISSN: 10267158 NLM ISO Abbreviation: J Drug Target Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Blood-Brain Barrier*/metabolism , Intercellular Adhesion Molecule-1*/metabolism , Brain*/metabolism , Drug Carriers* , Nanoparticles* , Drug Delivery Systems*, Astrocytes/metabolism ; Endothelial Cells/metabolism ; Pericytes/metabolism ; Humans ; Animals ; Lab-On-A-Chip Devices ; Microphysiological Systems ; Biological Transport

3D culture reveals dual role of ICAM-1 in mediating tissue-specific human MSC spheroid formation & enhanced immunomodulation.

Συγγραφείς: Wang LT; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan; Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, TMU, Taipei, Taiwan., Wang HH; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Doan DTT; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan., Lin YF; School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University (TMU), Taipei, Taiwan., Liao CY; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Hsu PJ; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Chang CC; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan., Yen ML; Department of Obstetrics & Gynecology, National Taiwan University (NTU) Hospital & College of Medicine, NTU, Taipei, Taiwan., Liu KJ; National Institute of Cancer Research, NHRI, Tainan, Taiwan., Sytwu HK; National Institute of Infectious Diseases & Vaccinology, NHRI, Zhunan, Taiwan; Graduate Institute of Microbiology & Immunology, National Defense Medical Center, Taipei, Taiwan., Yen BL; Regenerative Medicine Research Group, Institute of Cellular & System Medicine, National Health Research Institutes (NHRI), Zhunan, Taiwan. Electronic address: blyen@nhri.edu.tw.

Πηγή: Biomaterials [Biomaterials] 2026 Jul; Vol. 330, pp. 123998. Date of Electronic Publication: 2026 Jan 09.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Intercellular Adhesion Molecule-1*/immunology , Mesenchymal Stem Cells*/cytology , Mesenchymal Stem Cells*/immunology , Mesenchymal Stem Cells*/metabolism , Spheroids, Cellular*/cytology , Spheroids, Cellular*/immunology , Spheroids, Cellular*/metabolism , Cell Culture Techniques, Three Dimensional*/methods , Immunomodulation*, Placenta/cytology ; Bone Marrow Cells/cytology ; Humans ; Female ; Cell Proliferation ; Pregnancy ; Cells, Cultured ; Cell Adhesion ; Gene Expression Profiling

Deubiquitinase USP7 Regulates Neutrophil Extracellular Trap Formation and Inflammation in Lipopolysaccharide-Treated Mice Through ICAM-1 Expression.

Συγγραφείς: Xu H; Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China., Wang Q; Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China., Fan JX; Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China., Xu YF; Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China., Yu J; Department of Emergency, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Πηγή: The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2026 May; Vol. 42 (5), pp. e70133. Date of Electronic Publication: 2025 Oct 31.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Department of Public Health, Kaohsiung Medical University Country of Publication: China (Republic : 1949- ) NLM ID: 100960562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2410-8650 (Electronic) Linking ISSN: 1607551X NLM ISO Abbreviation: Kaohsiung J Med Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Extracellular Traps*/metabolism , Ubiquitin-Specific Peptidase 7*/metabolism , Ubiquitin-Specific Peptidase 7*/genetics , Sepsis*/metabolism , Sepsis*/chemically induced , Sepsis*/pathology , Sepsis*/genetics , Neutrophils*/metabolism , Inflammation*/metabolism , Inflammation*/pathology , Lipopolysaccharides*, Macrophages/metabolism ; Animals ; Mice ; Mice, Knockout ; Male ; Mice, Inbred C57BL ; Disease Models, Animal ; Ubiquitination

An ICAM1-Targeting Chimeric Costimulatory Receptor Mimics the Immune Synapse and Enhances Tumor-Specific T-cell Function.

Συγγραφείς: Min IM; Department of Radiology, Houston Methodist Research Institute, Houston, Texas.; Department of Radiology, Weill Cornell Medicine, New York, New York.; Department of Surgery, Weill Cornell Medicine, New York, New York., Yang Y; Department of Radiology, Houston Methodist Research Institute, Houston, Texas.; Department of Radiology, Weill Cornell Medicine, New York, New York., Stefanova D; Department of Surgery, Weill Cornell Medicine, New York, New York., Vedvyas Y; Department of Radiology, Houston Methodist Research Institute, Houston, Texas.; Department of Radiology, Weill Cornell Medicine, New York, New York., Babu DS; Department of Radiology, Houston Methodist Research Institute, Houston, Texas., Lee DH; Department of Radiology, Houston Methodist Research Institute, Houston, Texas., Alcaina Y; Department of Radiology, Weill Cornell Medicine, New York, New York., Riascos MC; Department of Surgery, Weill Cornell Medicine, New York, New York., Puc J; AffyImmune Therapeutics, Inc., Natick, Massachusetts., Chen KJ; Department of Surgery, Weill Cornell Medicine, New York, New York., Gonzalez-Valdivieso J; Department of Radiology, Weill Cornell Medicine, New York, New York., Thaiparambil J; Department of Radiology, Houston Methodist Research Institute, Houston, Texas., Bilal M; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., He B; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York., Burnett AC; Department of Radiology, Houston Methodist Research Institute, Houston, Texas., Zarnegar R; Department of Surgery, Weill Cornell Medicine, New York, New York., Fahey TJ 3rd; Department of Surgery, Weill Cornell Medicine, New York, New York., Jin MM; Department of Radiology, Houston Methodist Research Institute, Houston, Texas.; Department of Radiology, Weill Cornell Medicine, New York, New York.

Πηγή: Cancer immunology research [Cancer Immunol Res] 2026 Jul 02; Vol. 14 (7), pp. 1133-1149.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intercellular Adhesion Molecule-1*/immunology , Intercellular Adhesion Molecule-1*/metabolism , Immunological Synapses*/immunology , T-Lymphocytes*/immunology , T-Lymphocytes*/metabolism , Receptors, Chimeric Antigen*/immunology , Receptors, Chimeric Antigen*/metabolism , Immunotherapy, Adoptive*/methods, Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Lymphocyte Activation/immunology ; Humans ; Animals ; Mice ; Signal Transduction ; Cell Line, Tumor ; Xenograft Model Antitumor Assays

ICAM-1 promotes T cell glycolytic reprogramming and tumor infiltration to drive 18F-FDG PET flares following radiotherapy.

Συγγραφείς: Song R; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Zhao M; State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China., Zhang T; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Zhang Y; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Guo F; Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China., He H; Department of Pathology, Peking University Third Hospital, Beijing 100191, China., Zhou H; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Li K; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Wang J; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Du J; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Wang F; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital, Beijing 100142, China., Zhou S; Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Zhu H; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital, Beijing 100142, China., Wang J; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China., Zhang W; State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China., Yang Z; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital, Beijing 100142, China., Liu Z; Department of Nuclear Medicine, Peking University Cancer Hospital and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Nuclear Medicine, Peking University Third Hospital, Beijing 100191, China.; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Peking University Cancer Hospital, Beijing 100142, China.

Πηγή: Protein & cell [Protein Cell] 2026 Jul 01; Vol. 17 (7), pp. 631-643.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: Germany NLM ID: 101532368 Publication Model: Print Cited Medium: Internet ISSN: 1674-8018 (Electronic) Linking ISSN: 1674800X NLM ISO Abbreviation: Protein Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , T-Lymphocytes*/metabolism , T-Lymphocytes*/immunology , Lymphocytes, Tumor-Infiltrating*/metabolism , Lymphocytes, Tumor-Infiltrating*/immunology , Fluorodeoxyglucose F18* , Glycolysis* , Positron-Emission Tomography*, Lymphocyte Function-Associated Antigen-1/metabolism ; Animals ; Mice ; Humans ; Metabolic Reprogramming ; Mice, Inbred C57BL

ICAM-1 targeted extracellular vesicles loaded with HC-070 mitigate vascular oxidative stress and inflammation in obstructive sleep apnea hypopnea syndrome by inhibiting TRPC5.

Συγγραφείς: Zhang Y; Department of Respiratory and Critical Care Medicine, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China., Rong K; Department of Respiratory and Critical Care Medicine, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China., Zhang R; Department of Emergency, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China., Kuang J; Department of Neurology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China., Zhang M; Department of Neurology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China., Yu Y; Department of Emergency, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China. Electronic address: yuyichuan@hospital.cqmu.edu.cn., Yang Z; Department of Neurology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, 402160, China. Electronic address: yangzhao5140@sohu.com.

Πηγή: Free radical biology & medicine [Free Radic Biol Med] 2026 Jul; Vol. 250, pp. 30-48. Date of Electronic Publication: 2026 Mar 13.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Sleep Apnea, Obstructive*/pathology , Sleep Apnea, Obstructive*/metabolism , Sleep Apnea, Obstructive*/drug therapy , Sleep Apnea, Obstructive*/genetics , Inflammation*/pathology , Inflammation*/metabolism , Inflammation*/drug therapy , TRPC Cation Channels*/antagonists & inhibitors , TRPC Cation Channels*/genetics , TRPC Cation Channels*/metabolism , Extracellular Vesicles*/metabolism, Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Mesenchymal Stem Cells/metabolism ; Animals ; Humans ; Mice ; Human Umbilical Vein Endothelial Cells ; Male ; Disease Models, Animal

Evaluation of ICAM and VCAM as biomarkers in serum and bronchoscopic lavage samples of lung cancer patients.

Συγγραφείς: Gülbahar BN; Department of Pulmonary Medicine, Yakutiye Medical Research Center, School of Medicine, Ataturk University, Yakutiye, 25240, Erzurum, Turkey., Aksakal A; Department of Pulmonary Medicine, Yakutiye Medical Research Center, School of Medicine, Ataturk University, Yakutiye, 25240, Erzurum, Turkey. alperennaksakal@hotmail.com., Kerget B; Department of Pulmonary Medicine, Yakutiye Medical Research Center, School of Medicine, Ataturk University, Yakutiye, 25240, Erzurum, Turkey., Öztürk N; Department of Biochemistry, School of Medicine, Ataturk University, Yakutiye, Erzurum, Turkey., Araz Ö; Department of Pulmonary Medicine, Yakutiye Medical Research Center, School of Medicine, Ataturk University, Yakutiye, 25240, Erzurum, Turkey., Uçar EY; Department of Pulmonary Medicine, Yakutiye Medical Research Center, School of Medicine, Ataturk University, Yakutiye, 25240, Erzurum, Turkey., Sağlam L; Department of Pulmonary Medicine, Yakutiye Medical Research Center, School of Medicine, Ataturk University, Yakutiye, 25240, Erzurum, Turkey.

Πηγή: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2026 Jul; Vol. 28 (7), pp. 2690-2700. Date of Electronic Publication: 2026 Jan 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Country of Publication: Italy NLM ID: 101247119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1699-3055 (Electronic) Linking ISSN: 1699048X NLM ISO Abbreviation: Clin Transl Oncol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lung Neoplasms*/blood , Lung Neoplasms*/diagnosis , Lung Neoplasms*/mortality , Lung Neoplasms*/metabolism , Vascular Cell Adhesion Molecule-1*/blood , Vascular Cell Adhesion Molecule-1*/analysis , Vascular Cell Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/blood , Intercellular Adhesion Molecule-1*/analysis , Intercellular Adhesion Molecule-1*/metabolism , Biomarkers, Tumor*/blood , Biomarkers, Tumor*/analysis , Biomarkers, Tumor*/metabolism , Bronchoalveolar Lavage Fluid*/chemistry , Cell Adhesion Molecules*/blood , Cell Adhesion Molecules*/analysis , Cell Adhesion Molecules*/metabolism, Humans ; Male ; Female ; Middle Aged ; Cross-Sectional Studies ; Prospective Studies ; Prognosis ; Aged ; Bronchoscopy ; Adult ; Case-Control Studies ; ROC Curve ; Antigens, CD

ICAM signaling rewires the inflammatory communication network in pediatric gout.

Συγγραφείς: Yu S; Department of Pediatrics,Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China., Lu W; Department of Pediatrics,Guangzhou First People's Hospital, South China University of Technology, Guangzhou, Guangdong, China., Zhang D; Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China., Ren Q; Department of Rheumatology and Immunology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jun 29; Vol. 17, pp. 1871249. Date of Electronic Publication: 2026 Jun 29 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Gout*/immunology , Gout*/metabolism , Signal Transduction*/immunology , Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Intercellular Adhesion Molecule-1*/immunology , Inflammation*/immunology, Cell Communication/immunology ; Monocytes/immunology ; Monocytes/metabolism ; Humans ; Child ; Male ; Female ; Gene Expression Profiling ; Adolescent ; Single-Cell Analysis

CT-based radiogenomic prediction of ICAM1 and RAET1E as biomarkers of NK cytotoxicity in clear cell renal cell carcinoma.

Συγγραφείς: Ma X; Department of Radiology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.; Suzhou Key Laboratory for Integrated Stroke Prevention, Treatment, and Rehabilitation, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.; Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China., Yang J; Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China., Qian X; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China., Dou X; Department of Radiology, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Ji S; Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China., Dai Y; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China., Yang Y; Department of Nuclear Medicine, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Wang Y; Department of Radiology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China., Zhu J; Department of Radiology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jun 03; Vol. 17, pp. 1773251. Date of Electronic Publication: 2026 Jun 03 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Killer Cells, Natural*/immunology , Intercellular Adhesion Molecule-1*/genetics , Intercellular Adhesion Molecule-1*/metabolism , Kidney Neoplasms*/immunology , Kidney Neoplasms*/diagnostic imaging , Kidney Neoplasms*/genetics , Carcinoma, Renal Cell*/immunology , Carcinoma, Renal Cell*/diagnostic imaging , Carcinoma, Renal Cell*/genetics , Biomarkers, Tumor*/genetics , Tomography, X-Ray Computed*/methods, Humans ; Female ; Male ; Radiomics ; Middle Aged ; Aged ; Cytotoxicity, Immunologic ; Prognosis

Co-culture with fibroblasts in stiff 3D scaffolds increases CD54 and CD140a expression on macrophages.

Συγγραφείς: Ng JW; Department of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.; Centre for Cardiovascular Biology & Disease Research, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, VIC, Australia., Rao ST; Holsworth Biomedical Research Centre, Department of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia., Field EH; Department of Biology, School of Science, RMIT University, Melbourne, VIC, Australia.; Aikenhead Centre for Medical Discovery, Fitzroy, VIC, Australia., Ritchie K; Department of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.; Centre for Cardiovascular Biology & Disease Research, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, VIC, Australia., Wright MD; Department of Immunology & Pathology, Alfred Medical Research and Education Precinct, School of Translational Medicine, Monash University, Melbourne, VIC, Australia., Reynolds NP; Department of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.; Department of Biology, School of Science, RMIT University, Melbourne, VIC, Australia.; Aikenhead Centre for Medical Discovery, Fitzroy, VIC, Australia., Cutter SW; Department of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.; Centre for Cardiovascular Biology & Disease Research, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, VIC, Australia., Binger KJ; Department of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.; Centre for Cardiovascular Biology & Disease Research, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, VIC, Australia.; Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jun 03; Vol. 17, pp. 1771248. Date of Electronic Publication: 2026 Jun 03 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Macrophages*/metabolism , Macrophages*/immunology , Fibroblasts*/metabolism , Intercellular Adhesion Molecule-1*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Tissue Scaffolds*, Animals ; Coculture Techniques ; Mice ; Cells, Cultured ; Cell Communication ; Cell Culture Techniques, Three Dimensional

Integrated transcriptomic analysis reveals lymphatic Icam1-mediated immune dynamics after myocardial infarction.

Συγγραφείς: Chen XT; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; BGI Research, Shenzhen, Guangdong 518083, China., Hu BB; Pediatric Translational Medicine Institute and Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Zhang Z; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; BGI Research, Shenzhen, Guangdong 518083, China., Chen ZX; Pediatric Translational Medicine Institute and Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Chen SL; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; BGI Research, Shenzhen, Guangdong 518083, China., Su SX; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.; BGI Research, Shenzhen, Guangdong 518083, China., Zhang Z; Department of Cardiology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong 519000, China., Huang C; Department of Cardiology, Fuwai Yunnan Cardiovascular Hospital, Cardiovascular Hospital Affiliated to Kunming Medical University, Kunming, Yunnan 650000, China., Wang L; Department of Cardiovascular Medicine, Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China., Lai KS; Pediatric Translational Medicine Institute and Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Yang JJ; Pediatric Translational Medicine Institute and Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Wang Y; Pediatric Translational Medicine Institute and Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China., Fang XD; BGI Research, Sanya, Hainan 572025, China., Zhang Z; Pediatric Translational Medicine Institute and Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.; Shanghai Collaborative Innovative Center of Intelligent Medical Device and Active Health, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.; Core Research Laboratory, Fujian Children's Hospital, Fuzhou, Fujian 350012, China.; Department of Hainan Key Laboratory of Molecular Medicine for Women and Children's Health, Shanghai Children's Medical Center Hainan Branch, Shanghai Jiao Tong University School of Medicine, Sanya, Hainan 572000, China., Shen J; BGI Research, Shenzhen, Guangdong 518083, China. E-mail: juan.shen@genomics.cn., Zhang M; Pediatric Translational Medicine Institute and Pediatric Congenital Heart Disease Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. E-mail: minzhang5099@gmail.com.

Πηγή: Zoological research [Zool Res] 2026 May 18; Vol. 47 (3), pp. 691-705.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Science Press Country of Publication: China NLM ID: 101697192 Publication Model: Print Cited Medium: Internet ISSN: 2095-8137 (Print) Linking ISSN: 20958137 NLM ISO Abbreviation: Zool Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Myocardial Infarction*/immunology , Myocardial Infarction*/metabolism , Intercellular Adhesion Molecule-1*/genetics , Intercellular Adhesion Molecule-1*/metabolism , Lymphatic Vessels*/metabolism, Endothelial Cells/metabolism ; Animals ; Mice ; Gene Expression Profiling ; Gene Expression Regulation ; Mice, Knockout ; Male

Xuebijing alleviates septic myocardial injury by inhibiting ferroptosis mediated by the ICAM1/TLR signaling pathway.

Συγγραφείς: Meng X; Critical Care Medicine, Xuzhou Mining Group General Hospital, Xuzhou, PR China., Yan X; Emergency Department, Xuzhou Mining Group General Hospital, Xuzhou, PR China. yxm13593070445@163.com., Kan C; Occupational Disease Department, Xuzhou Mining Group General Hospital, Xuzhou, PR China., Li H; Critical Care Medicine, Xuzhou Mining Group General Hospital, Xuzhou, PR China., Han D; Critical Care Medicine, Xuzhou Mining Group General Hospital, Xuzhou, PR China., Guo Y; Critical Care Medicine, Xuzhou Mining Group General Hospital, Xuzhou, PR China., Xue P; Critical Care Medicine, Xuzhou Mining Group General Hospital, Xuzhou, PR China., Jiang Y; Critical Care Medicine, Xuzhou Mining Group General Hospital, Xuzhou, PR China.

Πηγή: Histology and histopathology [Histol Histopathol] 2026 Nov; Vol. 41 (11), pp. 1865-1876. Date of Electronic Publication: 2026 Apr 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Histology and Histopathology Country of Publication: Spain NLM ID: 8609357 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1699-5848 (Electronic) Linking ISSN: 02133911 NLM ISO Abbreviation: Histol Histopathol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Signal Transduction*/drug effects , Sepsis*/metabolism , Sepsis*/drug therapy , Sepsis*/complications , Sepsis*/pathology , Intercellular Adhesion Molecule-1*/metabolism , Drugs, Chinese Herbal*/pharmacology , Toll-Like Receptors*/metabolism , Ferroptosis*/drug effects, Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Animals ; Mice ; Male ; Disease Models, Animal ; Mice, Inbred C57BL