Targeting innate immunity in cancer: mechanistic foundations, therapeutic vaccination, and clinical translation.

Authors: Li X; Department of Stomatology, General Hospital of Northern Theater Command, Shenyang, China., Meng Y; Department of Stomatology, General Hospital of Northern Theater Command, Shenyang, China., Dong J; Department of Stomatology, General Hospital of Northern Theater Command, Shenyang, China., Ma Y; Department of Stomatology, General Hospital of Northern Theater Command, Shenyang, China., Liu D; Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, China., Zhang X; Department of Stomatology, General Hospital of Northern Theater Command, Shenyang, China., Zhao L; Department of Stomatology, General Hospital of Northern Theater Command, Shenyang, China.

Source: Frontiers in immunology [Front Immunol] 2026 Sep 18; Vol. 17, pp. 1941235. Date of Electronic Publication: 2026 Sep 18 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Neoplasms*/immunology , Neoplasms*/therapy , Neoplasms*/metabolism , Cancer Vaccines*/immunology , Cancer Vaccines*/therapeutic use , Immunity, Innate*, Tumor Microenvironment/immunology ; Immunotherapy/methods ; Humans ; Animals ; Innate Immunity Recognition ; Vaccination ; Translational Research, Biomedical

Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.

Authors: Kenney KM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Burgener SS; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Source: Bioscience reports [Biosci Rep] 2026 Oct 21; Vol. 46 (10).

Publication Type: Journal Article; Review

Journal Info: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

MeSH Terms: Glucocorticoids*/immunology , Glucocorticoids*/metabolism , Inflammation*/immunology , Inflammation*/metabolism , Inflammation*/pathology , Stress, Physiological*/immunology , Immunity, Innate*, Signal Transduction/immunology ; Humans ; Animals ; Innate Immunity Recognition

The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death.

Authors: Xiao N; Department of Microbiology, University of Chicago, Chicago, IL, USA., Lu Z; Department of Microbiology, University of Chicago, Chicago, IL, USA., Cooper DK; Department of Microbiology, University of Chicago, Chicago, IL, USA., Chen J; Department of Microbiology, University of Chicago, Chicago, IL, USA. jueqi@uchicago.edu.; Howard Taylor Ricketts Laboratory, University of Chicago, Lemont, IL, USA. jueqi@uchicago.edu.

Source: Cellular & molecular immunology [Cell Mol Immunol] 2026 Oct; Vol. 23 (10), pp. 1194-1218. Date of Electronic Publication: 2026 Sep 02.

Publication Type: Journal Article; Review

Journal Info: Publisher: Chinese Society of Immunology Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-0226 (Electronic) Linking ISSN: 16727681 NLM ISO Abbreviation: Cell Mol Immunol Subsets: MEDLINE

MeSH Terms: Inflammasomes*/metabolism , Inflammasomes*/immunology , NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , NLR Family, Pyrin Domain-Containing 3 Protein*/immunology , Immunity, Innate* , Signal Transduction*, Inflammation/immunology ; Humans ; Animals ; Cell Death ; Innate Immunity Recognition ; cGAS-STING Signaling Pathway

Multiple regulatory roles of UNC93B1 in innate immunity.

Authors: Yi L; Department of Clinical Laboratory, Yiyang Central Hospital, Yiyang, Hunan, China., Li Y; International Department, Shanghai Private Weiyu Middle School, China., Xiao X; Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China., Li J; Department of Family and Community Medicine, University of Illinois College of Medicine, Rockford, IL, USA., Yang Z; Shanghai Omics Biotechnology Co., Ltd, Shanghai, China., Zhang Y; Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China. Electronic address: yanzhaozhang@cmu.edu.cn., Xue M; Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China. Electronic address: xuemengzhou@zzu.edu.cn., Zheng C; Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. Electronic address: zheng.alan@hotmail.com.

Source: Cellular signalling [Cell Signal] 2026 Oct; Vol. 146, pp. 112692. Date of Electronic Publication: 2026 Jun 23.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE

MeSH Terms: Membrane Transport Proteins*/immunology , Membrane Transport Proteins*/metabolism , Immunity, Innate*, Neutrophils/immunology ; Autoimmune Diseases/immunology ; Virus Diseases/immunology ; Humans ; Animals ; Signal Transduction ; cGAS-STING Signaling Pathway ; Innate Immunity Recognition ; Membrane Proteins ; Toll-Like Receptors

Mechanisms linking sleep, innate immunity, and neuroinflammation.

Authors: Opp MR; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA. Electronic address: Mark.Opp@Colorado.Edu., Rowe RK; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA., Krueger JM; Department of Integrative Physiology & Neuroscience, Washington State University, Pullman, WA, USA.

Source: Brain, behavior, and immunity [Brain Behav Immun] 2026 Oct; Vol. 137, pp. 106803. Date of Electronic Publication: 2026 May 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE

MeSH Terms: Immunity, Innate*/physiology , Immunity, Innate*/immunology , Sleep*/physiology , Sleep*/immunology , Neuroinflammatory Diseases*/immunology , Neuroinflammatory Diseases*/metabolism, Cytokines/metabolism ; Brain/immunology ; Brain/metabolism ; Inflammation/immunology ; Signal Transduction/immunology ; Humans ; Animals ; Innate Immunity Recognition

ZBP1 and IFI16: novel innate sensors and inflammation regulation under infection stress.

Authors: Lu C; The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Xu B; The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Xiong Y; The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Source: Frontiers in immunology [Front Immunol] 2026 Sep 22; Vol. 17, pp. 1869593. Date of Electronic Publication: 2026 Sep 22 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: Phosphoproteins*/immunology , Phosphoproteins*/metabolism , Phosphoproteins*/chemistry , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/immunology , RNA-Binding Proteins*/chemistry , Inflammation*/immunology , Inflammation*/metabolism , Nuclear Proteins*/immunology , Nuclear Proteins*/metabolism , Nuclear Proteins*/chemistry , Infections*/immunology , Infections*/metabolism , Immunity, Innate*, Humans ; Animals ; Innate Immunity Recognition ; Signal Transduction

Redox-driven mitochondrial DNA stress in hepatocellular carcinoma: innate immune remodelling, tumour immune escape, and immunotherapy implications.

Authors: Chang Z; Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, China., Liu G; Emergency Department, The Affiliated Hospital of Yanbian University, Yanji, China., Zhang J; Department of Metabolic and Bariatric Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China., Lei H; Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, China., Quan H; Central Laboratory, The Affiliated Hospital of Yanbian University, Yanji, China., Piao Y; Emergency Department, The Affiliated Hospital of Yanbian University, Yanji, China.

Source: Frontiers in immunology [Front Immunol] 2026 Sep 04; Vol. 17, pp. 1903643. Date of Electronic Publication: 2026 Sep 04 (Print Publication: 2026).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

MeSH Terms: DNA, Mitochondrial*/genetics , DNA, Mitochondrial*/immunology , DNA, Mitochondrial*/metabolism , Carcinoma, Hepatocellular*/immunology , Carcinoma, Hepatocellular*/therapy , Carcinoma, Hepatocellular*/metabolism , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/pathology , Liver Neoplasms*/immunology , Liver Neoplasms*/therapy , Liver Neoplasms*/metabolism , Liver Neoplasms*/genetics , Liver Neoplasms*/pathology , Tumor Escape*/immunology , Immunity, Innate*, Mitochondria/metabolism ; Mitochondria/immunology ; Mitochondria/genetics ; Reactive Oxygen Species/metabolism ; Humans ; Oxidation-Reduction ; Animals ; Immunotherapy ; Oxidative Stress ; cGAS-STING Signaling Pathway ; Toll-Like Receptor 9 ; DNA Damage ; Signal Transduction ; Innate Immunity Recognition

Innate immune surveillance and nucleic acid sensing: Gatekeepers of inflammatory cell death in respiratory infectious diseases.

Authors: Thapa N; Department of Biotechnology, Kathmandu University, Dhulikhel 6250, Nepal; Department of Biomedicine and Translational Research, Research Institute for Bioscience and Biotechnology, Kathmandu 44700, Nepal., Jin Y; College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea., Han JH; College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea. Electronic address: joohui.han@chungbuk.ac.kr.

Source: Pharmacological research [Pharmacol Res] 2026 Sep; Vol. 231, pp. 108340. Date of Electronic Publication: 2026 Jul 14.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

MeSH Terms: Nucleic Acids*/immunology , Respiratory Tract Infections*/immunology , Respiratory Tract Infections*/virology , Respiratory Tract Infections*/pathology , Immunity, Innate* , Immunologic Surveillance*, Cell Death/immunology ; Inflammation/immunology ; Receptors, Pattern Recognition/immunology ; Humans ; Animals ; Innate Immunity Recognition ; Signal Transduction

An update on the Tenebrio molitor immune system.

Authors: Ramírez-Sotelo U; Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, 36050, Guanajuato, Gto, Mexico., Mora-Montes HM; Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta s/n, 36050, Guanajuato, Gto, Mexico. Electronic address: hmora@ugto.mx.

Source: Journal of invertebrate pathology [J Invertebr Pathol] 2026 Sep; Vol. 218, pp. 108689. Date of Electronic Publication: 2026 Jun 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 0014067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0805 (Electronic) Linking ISSN: 00222011 NLM ISO Abbreviation: J Invertebr Pathol Subsets: MEDLINE

MeSH Terms: Tenebrio*/immunology , Tenebrio*/microbiology , Immunity, Innate*, Hemocytes/immunology ; Animals ; Innate Immunity Recognition

Bepirovirsen induces innate immune activation in the liver potentially through TLR8 signaling.

Authors: Ermler ME; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA. Electronic address: megan.x.ermler@gsk.com., Delahaye JL; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA., Jordan W; Computational biology GSK, Collegeville, PA, USA., Nivarthi U; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA., DeHart A; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA., Jones K; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA., Das A; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA., Galwey N; BioStatistics, GSK, Stevenage, UK., Hoang B; Non-Clinical Histology, GSK, Collegeville, PA, USA., Terry RL; Non-Clinical Safety Pathology, GSK, Stevenage, UK., Tarrant J; Non-Clinical Safety Pathology, GSK, Collegeville, PA, USA., Sherina V; BioStatistics, GSK, Collegeville, PA, USA., Ray A; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA., Austin D; Clinical Pharmacology, GSK, London, UK., Singh JM; Clinical Biomarkers, GSK, Collegeville, PA, USA., Theodore D; Clinical Development, GSK, Durham, NC, USA., Paff M; Medical Development, GSK, Collegeville, PA, USA., You S; Vaccines and Infectious Disease Research Unit, GSK, Collegeville, PA, USA. Electronic address: shihyun.k.you@gsk.com.

Source: JHEP reports : innovation in hepatology [JHEP Rep] 2026 Sep; Vol. 8 (9), pp. 101923. Date of Electronic Publication: 2026 Jun 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: MEDLINE

MeSH Terms: Immunity, Innate*/drug effects , Toll-Like Receptor 8*/metabolism , Liver*/immunology , Liver*/drug effects , Hepatitis B, Chronic*/drug therapy , Hepatitis B, Chronic*/immunology , Antiviral Agents*/pharmacology, Signal Transduction/drug effects ; Cytokines/metabolism ; Leukocytes, Mononuclear/drug effects ; Humans ; Animals ; Mice ; Mice, Transgenic ; Toll-Like Receptor Agonists ; Female ; Innate Immunity Recognition ; Hexanols ; Pyrimidines

DNA-triggered AIM2 condensation orchestrates immune activation and regulation.

Authors: Li Q; School of Life Science, Beijing Institute of Technology, Beijing 100081, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Geng X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Yan H; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li Z; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Shi M; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China., Zhu Z; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Niu T; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Zhao C; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Shu K; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Gao Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Feng H; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Liu S; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Jiang Q; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China., Bu P; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li D; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, IDG/McGovern Institute for Brain Research, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China., Gao P; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China.

Source: Protein & cell [Protein Cell] 2026 Sep 01; Vol. 17 (9), pp. 807-820.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: Germany NLM ID: 101532368 Publication Model: Print Cited Medium: Internet ISSN: 1674-8018 (Electronic) Linking ISSN: 1674800X NLM ISO Abbreviation: Protein Cell Subsets: MEDLINE

MeSH Terms: DNA-Binding Proteins*/immunology , DNA-Binding Proteins*/chemistry , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Inflammasomes*/immunology , Inflammasomes*/metabolism , DNA*/immunology , DNA*/chemistry , DNA*/metabolism , Immunity, Innate*, Animals ; Humans ; Innate Immunity Recognition ; Mice ; Phase Separation

Innate immunity: current understandings and future perspectives.

Authors: Zou C; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.; Department of Hematology and Hematology Research Laboratory, West China Hospital, Sichuan University, Chengdu, China., Ma T; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China., Li J; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China. lijing1984@scu.edu.cn., Zhou X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. xikunzhou@scu.edu.cn.; Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, China. xikunzhou@scu.edu.cn.; Laboratory of Pathogen Research, West China Hospital, Sichuan University, Chengdu, China. xikunzhou@scu.edu.cn.

Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Aug 12; Vol. 11 (1). Date of Electronic Publication: 2026 Aug 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE

MeSH Terms: Immunity, Innate*/immunology , Immunity, Innate*/genetics , Inflammasomes*/immunology , Inflammasomes*/genetics , Autoimmune Diseases*/immunology , Autoimmune Diseases*/genetics , Receptors, Pattern Recognition*/immunology , Receptors, Pattern Recognition*/genetics , Neoplasms*/immunology , Neoplasms*/genetics, Signal Transduction/immunology ; Signal Transduction/genetics ; Humans ; Innate Immunity Recognition ; Animals ; Trained Immunity

DNA Sensing Pathways in Innate Immunity: Implications for Alzheimer's Disease Progression and Therapy.

Authors: Shi C; Center for Rehabilitation Medicine, Department of Rehabilitation Medicine, Rehabilitation & Sports Medicine Research Institute of Zhejiang Province, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China., Liu Y; Neurology Department, The Medical Center of Chinese, Beijing, China. yli26957@gmail.com., Zhu Y; Cancer Center, Department of Medical Oncology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

Source: Molecular neurobiology [Mol Neurobiol] 2026 Aug 05; Vol. 63 (1). Date of Electronic Publication: 2026 Aug 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/immunology , Alzheimer Disease*/therapy , Alzheimer Disease*/pathology , Immunity, Innate*/immunology , DNA*/metabolism , DNA*/immunology , Disease Progression* , Signal Transduction*, Toll-Like Receptor 9/metabolism ; Humans ; Animals ; Innate Immunity Recognition ; cGAS-STING Signaling Pathway ; Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase

Innate immune sensors of inflammasomes and PANoptosomes: structural-mechanistic insights and therapeutic implications.

Authors: Upadhyay S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Nagampalli R; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Resende S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Kanneganti TD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. Thirumala-Devi.Kanneganti@StJude.org.

Source: Cell research [Cell Res] 2026 Oct; Vol. 36 (10), pp. 747-768. Date of Electronic Publication: 2026 Sep 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE

MeSH Terms: Inflammasomes*/immunology , Inflammasomes*/metabolism , Inflammasomes*/chemistry , Immunity, Innate*, Inflammation/immunology ; Humans ; Animals ; Innate Immunity Recognition ; Signal Transduction

Molecular characterization, microbial recognition and immunomodulatory functions of a novel ladderlectin-like lectin (HoLL-like) from Hexagrammos otakii.

Authors: Wen Y; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China., Wei X; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China., He T; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China., Wang S; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China., Zhang Y; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China., Zhang Z; College of Environmental Sciences and Engineering, Dalian Maritime University, Dalian, 116026, China., Li J; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China., Wang X; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China., Wang W; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China. Electronic address: wangwei@dlou.edu.cn., Li X; Key Laboratory of Applied Biology and Aquaculture of Northern Fishes in Liaoning Province, Dalian Ocean University, Dalian, 116023, China; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Dalian Xinghai Bay Laboratory, Dalian, 116034, China. Electronic address: lixuejie@dlou.edu.cn.

Source: Fish & shellfish immunology [Fish Shellfish Immunol] 2026 Oct; Vol. 177, pp. 111603. Date of Electronic Publication: 2026 Jul 22.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH Terms: Immunity, Innate*/genetics , Fish Diseases*/immunology , Perciformes*/immunology , Perciformes*/genetics , Lectins, C-Type*/genetics , Lectins, C-Type*/immunology , Lectins, C-Type*/chemistry , Gene Expression Regulation*/immunology, Sequence Alignment/veterinary ; Fish Proteins/genetics ; Fish Proteins/chemistry ; Fish Proteins/immunology ; Vibrio/physiology ; Gene Expression Profiling/veterinary ; Vibrio Infections/immunology ; Vibrio Infections/veterinary ; Lectins/genetics ; Lectins/immunology ; Lectins/chemistry ; Animals ; Amino Acid Sequence ; Phylogeny ; Base Sequence ; Innate Immunity Recognition

Toll-like receptor 2 (TLR2) functions as a key regulator of inflammatory responses to Vibrio parahaemolyticus infection in the Manila clam (Ruditapes philippinarum).

Authors: Liang J; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China., Yu T; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China., Feng H; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China., Zhu X; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China., Liu M; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China., Xu Z; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China., Fang L; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China; College of Marine Science and Environment, Dalian Ocean University, Dalian, 116023, China., Li D; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China. Electronic address: lidongdong@dlou.edu.cn., Huo Z; College of Fisheries and Life Science, Dalian Ocean University, Dalian, 116023, China; Engineering Research Center of Shellfish Culture and Breeding in Liaoning Province, Dalian, 116023, China. Electronic address: huozm@dlou.edu.cn.

Source: Fish & shellfish immunology [Fish Shellfish Immunol] 2026 Oct; Vol. 177, pp. 111587. Date of Electronic Publication: 2026 Jul 09.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9505220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9947 (Electronic) Linking ISSN: 10504648 NLM ISO Abbreviation: Fish Shellfish Immunol Subsets: MEDLINE

MeSH Terms: Vibrio parahaemolyticus*/physiology , Bivalvia*/immunology , Bivalvia*/genetics , Bivalvia*/microbiology , Immunity, Innate*/genetics , Toll-Like Receptor 2*/genetics , Toll-Like Receptor 2*/chemistry , Toll-Like Receptor 2*/immunology , Toll-Like Receptor 2*/metabolism , Gene Expression Regulation*/immunology, Inflammation/immunology ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Animals ; Phylogeny ; Amino Acid Sequence ; Sequence Alignment ; Base Sequence ; Innate Immunity Recognition

dsRNA-mediated interference with RcβGRPs significantly reduced the resistance of Reticulitermes chinensis Snyder (Blattodea: Termitidae) to pathogens.

Authors: Xiong Y; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.; College of Forestry and Grassland, Nanjing Forestry University, Nanjing, China., Jiang D; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.; College of Forestry and Grassland, Nanjing Forestry University, Nanjing, China., Tang F; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.; College of Forestry and Grassland, Nanjing Forestry University, Nanjing, China.

Source: Pest management science [Pest Manag Sci] 2026 Oct; Vol. 82 (10), pp. 10459-10470. Date of Electronic Publication: 2026 Jul 07.

Publication Type: Journal Article

Journal Info: Publisher: Published for SCI by Wiley Country of Publication: England NLM ID: 100898744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4998 (Electronic) Linking ISSN: 1526498X NLM ISO Abbreviation: Pest Manag Sci Subsets: MEDLINE

MeSH Terms: Insect Proteins*/genetics , Insect Proteins*/immunology , Insect Proteins*/metabolism , Isoptera*/immunology , Isoptera*/genetics , Isoptera*/microbiology , Receptors, Pattern Recognition*/genetics , RNA Interference* , RNA, Double-Stranded* , Immunity, Innate*, Beauveria/physiology ; Bacillus thuringiensis/physiology ; Animals ; Innate Immunity Recognition ; Carrier Proteins

Human Immunodeficiency Virus Type 2 Vpx-mediated Degradation of TASOR Activates Innate Immune Sensing of Nucleic Acids in Infected Cells.

Authors: Hanson HM; Molecular, Cellular, Developmental Biology & Genetics Graduate Program, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA., Damkot MR; Institute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA., Mansky LM; Molecular, Cellular, Developmental Biology & Genetics Graduate Program, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA; Department of Diagnostic & Biological Sciences, School of Dentistry, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota - Twin Cities, Minneapolis, MN 55455, USA. Electronic address: mansky@umn.edu.

Source: Journal of molecular biology [J Mol Biol] 2026 Oct 01; Vol. 438 (19), pp. 169879. Date of Electronic Publication: 2026 May 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

MeSH Terms: Viral Regulatory and Accessory Proteins*/metabolism , Viral Regulatory and Accessory Proteins*/genetics , HIV-2*/immunology , HIV-2*/genetics , HIV Infections*/virology , HIV Infections*/immunology , HIV Infections*/genetics , HIV Infections*/metabolism , Immunity, Innate*, SAM Domain and HD Domain-Containing Protein 1/metabolism ; Host-Pathogen Interactions/immunology ; Humans ; cGAS-STING Signaling Pathway ; Virus Replication ; Innate Immunity Recognition ; THP-1 Cells

Synthetic FLS2 receptor oligomer boosts plant innate immunity.

Authors: Ma Z; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Yazhouwan National Laboratory, Sanya 572024, Hainan, China., Xie Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Zhu X; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Chng CP; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Liang Q; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Huang C; School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore 639798, Singapore., Miao Y; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.; Institute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, Singapore.

Source: Science advances [Sci Adv] 2026 Sep 25; Vol. 12 (39), pp. eaeg6872. Date of Electronic Publication: 2026 Sep 25.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH Terms: Arabidopsis*/immunology , Arabidopsis*/genetics , Arabidopsis*/metabolism , Arabidopsis Proteins*/chemistry , Arabidopsis Proteins*/metabolism , Arabidopsis Proteins*/genetics , Protein Kinases*/metabolism , Protein Kinases*/chemistry , Protein Kinases*/genetics , Plant Immunity* , Immunity, Innate* , Protein Multimerization*, Signal Transduction ; Innate Immunity Recognition

Innate immune recognition of Debaryomyces hansenii requires Dectin-1-Card9 signaling.

Authors: Newhall KP; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, Ohio, USA.; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., McNeer SK; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, Ohio, USA.; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Espenschied ST; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, Ohio, USA., Dolan EG; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA., Zhou JY; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, Ohio, USA., Hogan DA; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA., Stappenbeck TS; Department of Inflammation and Immunity, Cleveland Clinic Research, Cleveland, Ohio, USA.; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.

Source: Infection and immunity [Infect Immun] 2026 Sep 08; Vol. 94 (9), pp. e0015726. Date of Electronic Publication: 2026 Aug 04.

Publication Type: Journal Article

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

MeSH Terms: Lectins, C-Type*/metabolism , Lectins, C-Type*/genetics , Lectins, C-Type*/immunology , CARD Signaling Adaptor Proteins*/metabolism , CARD Signaling Adaptor Proteins*/genetics , CARD Signaling Adaptor Proteins*/immunology , Debaryomyces*/immunology , Signal Transduction* , Immunity, Innate*, Macrophages/immunology ; Macrophages/microbiology ; Macrophages/metabolism ; Dectin-1 ; Innate Immunity Recognition ; Humans ; Animals ; Phagocytosis ; Mice