Intermediate Filament Protein BFSP1 Maintains Oocyte Asymmetric Division by Modulating Spindle Length.

Συγγραφείς: Li Y; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China., Zhang H; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China., Zeng W; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China., Miao Y; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China., Sun S; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China., Zhang Y; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China., Xiong B; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.; College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.

Πηγή: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2025 Jul; Vol. 12 (28), pp. e2504066. Date of Electronic Publication: 2025 May 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Oocytes*/metabolism , Oocytes*/cytology , Spindle Apparatus*/metabolism , Microtubule-Associated Proteins*/metabolism , Microtubule-Associated Proteins*/genetics , Intermediate Filament Proteins*/metabolism , Intermediate Filament Proteins*/genetics, Meiosis/physiology ; Intermediate Filaments/metabolism ; Microtubules/metabolism ; Animals ; Female ; Mice

Cardiomyopathy-Associated Mutations in a Hotspot Region at the C-Terminal Part of Desmin Coil-2 Domain Impair the Intermediate Filament Assembly.

Συγγραφείς: Reckmann J; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany.; Experimental Biophysics & Applied Nanoscience, Faculty of Physics (J.R., F.K., D.A., V.W.), Bielefeld University, Germany., Milting H; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany., Voß S; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany., Radukic MT; Cellular and Molecular Biotechnology, Faculty of Technology (M.T.R., K.M.M.), Bielefeld University, Germany., Klag F; Experimental Biophysics & Applied Nanoscience, Faculty of Physics (J.R., F.K., D.A., V.W.), Bielefeld University, Germany., Flottmann F; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany.; Department of Zoology and Developmental Biology, Osnabrück University, Germany (F.F.)., Lütkemeyer A; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany., Groß J; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany., Gärtner A; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany., Landwehr S; Biostatistics and Medical Biometry, Medical School OWL (S.L., A.H.), Bielefeld University, Germany., Anselmetti D; Experimental Biophysics & Applied Nanoscience, Faculty of Physics (J.R., F.K., D.A., V.W.), Bielefeld University, Germany., Hoyer A; Biostatistics and Medical Biometry, Medical School OWL (S.L., A.H.), Bielefeld University, Germany., Müller KM; Cellular and Molecular Biotechnology, Faculty of Technology (M.T.R., K.M.M.), Bielefeld University, Germany., Gummert J; Clinic of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum (J. Gummert), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany., Walhorn V; Experimental Biophysics & Applied Nanoscience, Faculty of Physics (J.R., F.K., D.A., V.W.), Bielefeld University, Germany., Brodehl A; Ruhr-University Bochum, Heart and Diabetes Center North Rhine Westphalia, Clinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute (J.R., H.M., S.V., F.F., A.L., J. Groß, A.G., A.B.), Medical School OWL (University of Bielefeld), Bad Oeynhausen, Germany.

Πηγή: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2026 Aug; Vol. 19 (4), pp. e005653. Date of Electronic Publication: 2026 Jul 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101714113 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-8300 (Electronic) Linking ISSN: 25748300 NLM ISO Abbreviation: Circ Genom Precis Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Desmin*/genetics , Desmin*/metabolism , Desmin*/chemistry , Cardiomyopathies*/genetics , Cardiomyopathies*/metabolism , Cardiomyopathies*/pathology , Intermediate Filaments*/metabolism , Intermediate Filaments*/genetics , Mutation*, Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Humans ; Protein Domains ; Mutagenesis, Site-Directed ; Animals

NADPH oxidase-dependent reactive oxygen species upregulate KCa3.1 to promote atrial fibroblast activation.

Συγγραφείς: Wu J; Department of Pathology and Pathophysiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China., Zhu Y; Department of Biopharmaceutical Sciences, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215123, China., Wu Y; Department of Pathology and Pathophysiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China., Liu X; Department of Pathology and Pathophysiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China., Jiang W; Department of Pathology and Pathophysiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China., Wang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, 76 West Yanta Road, Xi'an, Shaanxi, 710061, China., Wang Z; Department of Pathology and Pathophysiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China., Li M; Institute of Biology and Medical Sciences, Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China., Liu L; Department of Pathology and Pathophysiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China., Zhao J; Department of Pharmacy, Northern Jiangsu People's Hospital, Yangzhou, 225001, China. Electronic address: zhaojinghmu@163.com., Zhao L; Department of Pathology and Pathophysiology, School of Basic Medical Science, Suzhou Medical College of Soochow University, 199 Ren-ai Road, Suzhou, Jiangsu, 215123, China. Electronic address: lmzhao@suda.edu.cn.

Πηγή: Experimental cell research [Exp Cell Res] 2026 Aug 01; Vol. 461 (1), pp. 115105. Date of Electronic Publication: 2026 Jun 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Reactive Oxygen Species*/metabolism , Fibroblasts*/metabolism , Fibroblasts*/drug effects , Intermediate-Conductance Calcium-Activated Potassium Channels*/metabolism , Intermediate-Conductance Calcium-Activated Potassium Channels*/genetics , NADPH Oxidases*/metabolism , Heart Atria*/metabolism , Heart Atria*/pathology , Heart Atria*/cytology, Up-Regulation/drug effects ; Angiotensin II/pharmacology ; NADPH Oxidase 4/metabolism ; NADPH Oxidase 4/genetics ; Hydrogen Peroxide/pharmacology ; NADPH Oxidase 2/metabolism ; NADPH Oxidase 2/genetics ; Animals ; Rats ; Cells, Cultured ; Rats, Sprague-Dawley ; Male ; Cell Movement ; Cell Proliferation

K⁺ Channels in Membrane Potential Dynamics and Migration of Neutrophil Granulocytes.

Συγγραφείς: Ulu T; Institut für Physiologie II, University Münster, Münster, Germany., Siemer H; Institut für Physiologie II, University Münster, Münster, Germany., Heuer A; Institut für Physiologie II, University Münster, Münster, Germany., Schimmelpfennig S; Institut für Physiologie II, University Münster, Münster, Germany., Dieterich P; Institut für Physiologie, TU Dresden, Dresden, Germany., Borrego J; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Panyi G; Department of Biophysics and Cell Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Schwab A; Institut für Physiologie II, University Münster, Münster, Germany.

Πηγή: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2026 Oct; Vol. 359 (10), pp. e70365.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neutrophils*/metabolism , Neutrophils*/drug effects , Neutrophils*/physiology , Membrane Potentials*/drug effects , Potassium Channels, Inwardly Rectifying*/metabolism , Potassium Channels, Inwardly Rectifying*/antagonists & inhibitors , Intermediate-Conductance Calcium-Activated Potassium Channels*/metabolism , Intermediate-Conductance Calcium-Activated Potassium Channels*/antagonists & inhibitors , Kv1.3 Potassium Channel*/metabolism , Kv1.3 Potassium Channel*/antagonists & inhibitors, Leukotriene B4/metabolism ; Complement C5a/metabolism ; Complement C5a/pharmacology ; Potassium Channel Blockers/pharmacology ; Humans ; Chemotaxis ; Cell Movement

Kcnn4 Knockout Induces Salivary Gland Fibrosis, Immune Cell Infiltration, and B-Cell Dysfunction in Mice.

Συγγραφείς: Zhang Y; Department of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, and People's Hospital of Henan University, Zhengzhou, China., Zheng S; Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China., Jiang D; Academy of Medical Science, Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou, China., Cui C; Department of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, and People's Hospital of Henan University, Zhengzhou, China., Zhang X; Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China., Tao H; Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China., Fu G; Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China., Cheng L; Institute of Hematology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, Henan, China., Duan S; Henan Provincial People's Hospital, Henan Eye Hospital, Henan Eye Institute, Zhengzhou University People's Hospital, Henan University People's Hospital, Zhengzhou, China.

Πηγή: Chemical biology & drug design [Chem Biol Drug Des] 2026 Oct; Vol. 108 (4), pp. e70412.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101262549 Publication Model: Print Cited Medium: Internet ISSN: 1747-0285 (Electronic) Linking ISSN: 17470277 NLM ISO Abbreviation: Chem Biol Drug Des Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intermediate-Conductance Calcium-Activated Potassium Channels*/genetics , Intermediate-Conductance Calcium-Activated Potassium Channels*/deficiency , Intermediate-Conductance Calcium-Activated Potassium Channels*/metabolism , B-Lymphocytes*/immunology , B-Lymphocytes*/metabolism , B-Lymphocytes*/cytology , Salivary Glands*/pathology , Salivary Glands*/metabolism , Salivary Glands*/immunology, Animals ; Mice, Knockout ; Mice ; Fibrosis ; Mice, Inbred C57BL

Metabolic Stress Shifts the Function of KCa3.1 Channels in Pancreatic Beta Cells From a Regulator of Membrane Potential to a Proapoptotic Factor.

Συγγραφείς: Hense J; Institute of Pharmaceutical and Medicinal Chemistry, Department of Pharmacology, University of Münster, Münster, Germany., Beuke L; Institute of Pharmaceutical and Medicinal Chemistry, Department of Pharmacology, University of Münster, Münster, Germany., Kick C; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany., Wünsch B; Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany., Düfer M; Institute of Pharmaceutical and Medicinal Chemistry, Department of Pharmacology, University of Münster, Münster, Germany.

Πηγή: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2026 Oct; Vol. 359 (10), pp. e70344.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intermediate-Conductance Calcium-Activated Potassium Channels*/metabolism , Intermediate-Conductance Calcium-Activated Potassium Channels*/antagonists & inhibitors , Insulin-Secreting Cells*/metabolism , Insulin-Secreting Cells*/drug effects , Apoptosis*/drug effects , Stress, Physiological*, Membrane Potentials/drug effects ; Glucose/pharmacology ; Glucose/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Triphenylmethyl Compounds/pharmacology ; Calcium Channels, L-Type/metabolism ; Animals ; Mice ; Cells, Cultured ; Acetamides

Activation of KCa3.1 K⁺ Channel Suppresses COX2- and ARG1-Dependent Immunosuppressive Metabolic Programs in THP-1-Derived M2-like Macrophages.

Συγγραφείς: Kajikuri J; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan., Kitahara A; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan., Matsui M; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan., Maeda Y; Omics Analysis Laboratory, Open Facility Center, Fujita Health University, Toyoake 470-1192, Japan., Kito H; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan., Yamaguchi Y; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan., Otsuka R; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan., Ohya S; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.

Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Sep 23; Vol. 27 (19). Date of Electronic Publication: 2026 Sep 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Arginase*/metabolism , Arginase*/genetics , Intermediate-Conductance Calcium-Activated Potassium Channels*/metabolism , Intermediate-Conductance Calcium-Activated Potassium Channels*/genetics , Macrophages*/metabolism , Macrophages*/immunology , Cyclooxygenase 2*/metabolism , Cyclooxygenase 2*/genetics, Dinoprostone/metabolism ; Arginine/metabolism ; Humans ; THP-1 Cells ; Cell Differentiation ; Signal Transduction

Curcumin attenuates acrylamide-induced cerebellar neurofilament accumulation, BDNF decline and motor dysfunction.

Συγγραφείς: Duan L; Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong-Road, Wuhan 430030, PR China., Dang Z; The First Clinical College of Wuhan University, 238 Jiefang-Road, Wuchang District, Wuhan 430060, PR China., Li Z; The First Clinical College of Wuhan University, 238 Jiefang-Road, Wuchang District, Wuhan 430060, PR China., Zhang Y; Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong-Road, Wuhan 430030, PR China., Yan D; Department of Pathology, Renmin Hospital of Wuhan University, 238 Jiefang-Road, Wuchang District, Wuhan 430060, PR China. Electronic address: dandanyan@whu.edu.cn., Yan H; Department of Health Toxicology, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong-Road, Wuhan 430030, PR China. Electronic address: yanhong@mails.tjmu.edu.cn.

Πηγή: Neurotoxicology [Neurotoxicology] 2026 Sep; Vol. 116, pp. 103548. Date of Electronic Publication: 2026 Aug 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7905589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9711 (Electronic) Linking ISSN: 0161813X NLM ISO Abbreviation: Neurotoxicology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Brain-Derived Neurotrophic Factor*/metabolism , Curcumin*/pharmacology , Acrylamide*/toxicity , Cerebellum*/drug effects , Cerebellum*/metabolism , Cerebellum*/pathology , Neuroprotective Agents*/pharmacology , Neurofilament Proteins*/metabolism , Intermediate Filaments*/drug effects , Intermediate Filaments*/metabolism , Motor Activity*/drug effects, Oxidative Stress/drug effects ; Cyclic AMP Response Element-Binding Protein/metabolism ; Animals ; Male ; Rats ; Rats, Sprague-Dawley

Utility of Point-of-Care Ultrasound (PoCUS) in Intermediate and Long-Term Care Geriatric Settings.

Συγγραφείς: Sánchez-Rodríguez JL; Department of Geriatrics, Hospital de la Santa Creu, Tortosa, Tarragona, Spain. Electronic address: joseluis.sanchez@saluttortosa.cat., Gonzalez-Casanova AM; Department of Geriatrics, Hospital de la Santa Creu, Tortosa, Tarragona, Spain., Abramson L; Division of Geriatrics, Duke University School of Medicine, Durham, NC, USA., Martínez-Almazán E; Department of Geriatrics, Hospital de la Santa Creu, Tortosa, Tarragona, Spain.

Πηγή: Journal of the American Medical Directors Association [J Am Med Dir Assoc] 2026 Sep; Vol. 27 (9), pp. 106366. Date of Electronic Publication: 2026 Jul 17.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 100893243 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-9375 (Electronic) Linking ISSN: 15258610 NLM ISO Abbreviation: J Am Med Dir Assoc Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Geriatric Assessment*/methods , Point-of-Care Systems* , Long-Term Care* , Intermediate Care Facilities*, Ultrasonography/statistics & numerical data ; Humans ; Retrospective Studies ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Male ; Aged

CRISPR/Cpf1-mediated knockout of FLG in human induced pluripotent stem cells generates a model for studying epidermal barrier dysfunction.

Συγγραφείς: Ntzani ER; Environmental Adaptation and Cellular Resilience Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; AHR Signaling & Environmentally-induced Skin Damage Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany., Ramachandran H; Genome Engineering and Model Development Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany., Papadopoulou M; Environmental Adaptation and Cellular Resilience Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany., Binder S; Environmental Adaptation and Cellular Resilience Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany., Hildebrandt B; Institute of Human Genetics, Medical Faculty and University Hospital, Heinrich-Heine-University, Düsseldorf, Germany., Haarmann-Stemmann T; AHR Signaling & Environmentally-induced Skin Damage Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Electronic address: thomas.haarmann-stemmann@iuf-duesseldorf.de., Rossi A; Environmental Adaptation and Cellular Resilience Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; Genome Engineering and Model Development Laboratory, IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Electronic address: andrea.rossi@IUF-duesseldorf.de.

Πηγή: Stem cell research [Stem Cell Res] 2026 Sep; Vol. 95, pp. 104056. Date of Electronic Publication: 2026 Jul 06.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Induced Pluripotent Stem Cells*/metabolism , Induced Pluripotent Stem Cells*/cytology , CRISPR-Cas Systems*/genetics , Epidermis*/metabolism , Epidermis*/pathology , Intermediate Filament Proteins*/genetics , Intermediate Filament Proteins*/metabolism , Gene Knockout Techniques*, Humans ; Filaggrin Proteins ; Cell Differentiation ; Cell Line

Integrating Paediatric Intermediate Care Units Into Tiered Care Systems: A Narrative Review and Italian Perspective.

Συγγραφείς: Brisca G; Neonatal and Pediatric Intensive Care Unit, Intermediate Care Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Pirlo D; Neonatal and Pediatric Intensive Care Unit, Intermediate Care Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Romanengo M; Neonatal and Pediatric Intensive Care Unit, Intermediate Care Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Moscatelli A; Neonatal and Pediatric Intensive Care Unit, Intermediate Care Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Πηγή: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2026 Sep; Vol. 115 (9), pp. 1872-1877. Date of Electronic Publication: 2026 May 28.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Wiley-Blackwell Country of Publication: Norway NLM ID: 9205968 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-2227 (Electronic) Linking ISSN: 08035253 NLM ISO Abbreviation: Acta Paediatr Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intermediate Care Facilities*/organization & administration , Hospitals, Pediatric*/organization & administration, Humans ; Italy ; Child ; Pediatrics

Neuronal overexpression of Kcnn1 in A53T α-synuclein mice suppresses phospho-serine 129 α-synuclein formation and doubles survival time.

Συγγραφείς: Nagy M; Department of Genetics, Yale School of Medicine, New Haven, CT 06510., Fenton WA; Department of Genetics, Yale School of Medicine, New Haven, CT 06510., Horwich AL; Department of Genetics, Yale School of Medicine, New Haven, CT 06510.

Πηγή: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Aug 25; Vol. 123 (34), pp. e2622262123. Date of Electronic Publication: 2026 Aug 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Ιατρικοί όροι (MeSH): alpha-Synuclein*/metabolism , alpha-Synuclein*/genetics , Neurons*/metabolism , Intermediate-Conductance Calcium-Activated Potassium Channels*/genetics , Intermediate-Conductance Calcium-Activated Potassium Channels*/metabolism , Parkinson Disease*/metabolism , Parkinson Disease*/genetics, Serine/metabolism ; Animals ; Mice ; Mice, Transgenic ; Humans ; Phosphorylation ; Disease Models, Animal

MyD88 restricts dysbiosis-mediated inflammation in filaggrin deficient skin.

Συγγραφείς: Wu MJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Ravipati A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Wang Y; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Feller LE; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Chu A; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Damarla R; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Li Z; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Tsoi LC; Department of Dermatology, University of Michigan, Ann Arbor, Michigan, United States of America., Griffin R; Dermatology Branch, NIAMS, NIH, Bethesda, Maryland, United States of America., Hou P; Dermatology Branch, NIAMS, NIH, Bethesda, Maryland, United States of America., Liang H; Dermatology Branch, NIAMS, NIH, Bethesda, Maryland, United States of America., Geha R; Division of Immunology, Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America., Segre JA; Translational and Functional Genomics Branch, NHGRI, NIH, Bethesda, Maryland, United States of America., Kong HH; Dermatology Branch, NIAMS, NIH, Bethesda, Maryland, United States of America., Gudjonsson JE; Department of Dermatology, University of Michigan, Ann Arbor, Michigan, United States of America., Archer NK; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Πηγή: PloS one [PLoS One] 2026 Aug 14; Vol. 21 (8), pp. e0353968. Date of Electronic Publication: 2026 Aug 14 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Myeloid Differentiation Factor 88*/genetics , Myeloid Differentiation Factor 88*/metabolism , Dysbiosis*/genetics , Dysbiosis*/immunology , Skin*/pathology , Skin*/microbiology , Skin*/metabolism , Skin*/immunology , Intermediate Filament Proteins*/deficiency , Intermediate Filament Proteins*/genetics , Inflammation*/pathology , Inflammation*/genetics , Inflammation*/metabolism , Dermatitis, Atopic*/genetics , Dermatitis, Atopic*/pathology , Dermatitis, Atopic*/immunology , Dermatitis, Atopic*/microbiology , Dermatitis, Atopic*/metabolism, Interleukin-17/metabolism ; Animals ; Filaggrin Proteins ; Mice ; Mice, Knockout ; Skin Microbiome ; Signal Transduction

Patterns of medical intermediate care unit use in critically ill very old patients in France.

Συγγραφείς: Migeon A; Department of Geriatrics, Tours University Hospital, Tours, France.; Clinical Data Center, Department of Public Health, Epidemiology Unit EpiDcliC, Tours University Hospital, Tours, France., Demiselle J; University of Strasbourg (UNISTRA), Department of Medicine, FHUTARGET, Medical Intensive Care Unit, Strasbourg University Hospital, Hautepierre Hospital, Strasbourg, France.; UMR 1260, INSERM (French National Institute of Health and Medical Research), Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France., Godillon L; Clinical Data Center, Department of Public Health, Epidemiology Unit EpiDcliC, Tours University Hospital, Tours, France., Leroy V; Department of Geriatrics, Tours University Hospital, Tours, France.; INSERM (French National Institute of Health and Medical Research), UMR 1253, iBrain, University of Tours, Tours, France., Grammatico-Guillon L; Clinical Data Center, Department of Public Health, Epidemiology Unit EpiDcliC, Tours University Hospital, Tours, France.; Research Unit MAVIVH, INSERM U1259, Medical School, University of Tours, Tours, France., Guillon A; Intensive Care Unit, Tours University Hospital, University of Tours, 2 Bd Tonnellé, 37044 Tours Cedex 9, Tours, France. antoine.guillon@univ-tours.fr.; INSERM (French National Institute of Health and Medical Research), UMR 1100, Research Center for Respiratory Diseases (CEPR), University of Tours, Tours, France. antoine.guillon@univ-tours.fr.

Πηγή: European geriatric medicine [Eur Geriatr Med] 2026 Aug; Vol. 17 (4), pp. 1793-1802. Date of Electronic Publication: 2026 May 13.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101533694 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1878-7649 (Print) Linking ISSN: 18787649 NLM ISO Abbreviation: Eur Geriatr Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Critical Illness*/therapy , Critical Illness*/mortality , Intensive Care Units*/statistics & numerical data , Intermediate Care Facilities*/statistics & numerical data , Critical Care*/statistics & numerical data, France/epidemiology ; Length of Stay/statistics & numerical data ; Humans ; Female ; Aged, 80 and over ; Retrospective Studies ; Male ; Aged ; Middle Aged ; Adult ; Adolescent ; Young Adult ; Hospital Mortality

The unusual suspect: A novel role for intermediate filament proteins in mitochondrial morphology.

Συγγραφείς: Hemel IMGM; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Steen C; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Denil SLIJ; Flemish Institute for Technological Research (VITO) 2400 Mol, Belgium., Ertaylan G; Flemish Institute for Technological Research (VITO) 2400 Mol, Belgium., Kutmon M; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Adriaens M; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands., Gerards M; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht 6229 EN the Netherlands. Electronic address: mike.gerards@maastrichtuniversity.nl.

Πηγή: Mitochondrion [Mitochondrion] 2025 Mar; Vol. 81, pp. 102008. Date of Electronic Publication: 2025 Feb 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100968751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8278 (Electronic) Linking ISSN: 15677249 NLM ISO Abbreviation: Mitochondrion Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Mitochondria*/metabolism , Vimentin*/metabolism , Vimentin*/genetics , Intermediate Filament Proteins*/metabolism , Intermediate Filament Proteins*/genetics , Mitochondrial Proteins*/metabolism , Mitochondrial Proteins*/genetics , Mitochondrial Dynamics*, Intermediate Filaments/metabolism ; Humans ; Protein Interaction Mapping

Neurofilament transport kinetics can be explained by the activity of small numbers of independent kinesin and dynein motors.

Συγγραφείς: Nowier RM; Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, OH, USA., Johnson CM; Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, OH, USA., Fenn JD; Department of Neuroscience, Ohio State University, Columbus, OH, USA., Brown A; Department of Neuroscience, Ohio State University, Columbus, OH, USA. Electronic address: brown.2302@osu.edu., Jung P; Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, OH, USA. Electronic address: jungp@ohio.edu.

Πηγή: Biophysical journal [Biophys J] 2026 Oct 20; Vol. 125 (20), pp. 5937-5957. Date of Electronic Publication: 2026 Sep 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Dyneins*/metabolism , Kinesins*/metabolism , Intermediate Filaments*/metabolism, Kinetics ; Animals ; Models, Biological ; Stochastic Processes

Type III intermediate filaments as novel CoAlation targets.

Συγγραφείς: Goya-Iglesias N; Department of Molecular and Cellular Biosciences, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain., Yu BYK; Department of Structural and Molecular Biology, University College London, London, UK., Gout I; Department of Structural and Molecular Biology, University College London, London, UK.; Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv, Ukraine., Pérez-Sala D; Department of Molecular and Cellular Biosciences, Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

Πηγή: Redox report : communications in free radical research [Redox Rep] 2026 Dec 31; Vol. 31 (1), pp. 2692797. Date of Electronic Publication: 2026 Jun 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9511366 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1743-2928 (Electronic) Linking ISSN: 13510002 NLM ISO Abbreviation: Redox Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Vimentin*/metabolism , Intermediate Filaments*/metabolism , Desmin*/metabolism , Glial Fibrillary Acidic Protein*/metabolism, Cysteine/metabolism ; Humans ; Animals ; Protein Processing, Post-Translational ; Oxidative Stress ; Oxidation-Reduction

Municipal intermediate care services in Denmark and Norway: a cross-country comparative analysis.

Συγγραφείς: Udesen SEJ; Emergency Medicine Research Unit, University of Southern Denmark, Odense, Denmark.; Department of Public Health, University of Southern Denmark, Odense, Denmark., Sogstad MKR; Centre for Care Research, Norwegian University of Science and Technology-NTNU, Trondheim, Norway., Veenstra M; Centre for Care Research, Norwegian University of Science and Technology-NTNU, Trondheim, Norway.; Health Service Research Unit (HØKH), Akershus University Hospital, Lørenskog, Norway., Lassen AT; Emergency Medicine Research Unit, University of Southern Denmark, Odense, Denmark.; Department of Emergency Medicine, Odense University Hospital, Odense, Denmark., Skinner MS; Centre for Care Research, Norwegian University of Science and Technology-NTNU, Trondheim, Norway.

Πηγή: Scandinavian journal of primary health care [Scand J Prim Health Care] 2026 Dec; Vol. 44 (1), pp. 2644949. Date of Electronic Publication: 2026 May 11.

Τύπος έκδοσης: Journal Article; Comparative Study

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8510679 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1502-7724 (Electronic) Linking ISSN: 02813432 NLM ISO Abbreviation: Scand J Prim Health Care Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Intermediate Care Facilities*/organization & administration , Community Health Services*/organization & administration, Norway ; Denmark ; Humans ; Health Care Reform ; Patient Discharge

Choroidal thickness on optical coherence tomography as a longitudinal predictor of visual outcomes in intermediate uveitis.

Συγγραφείς: Biswal S; Department of Medical Retina and Uvea, Sankara Eye Hospital, Shivamogga, India., Sagar P; Department of Medical Retina and Uvea, Sankara Eye Hospital, Shivamogga, India., Just MD; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Merten NR; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Berger M; Core Facility Biostatistics, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany., Terheyden JH; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Schmid M; Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, University of Bonn, Bonn, Germany., Holz FG; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany., Finger RP; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany.; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Wintergerst MWM; Department of Ophthalmology, University Hospital Bonn, University of Bonn, Bonn, Germany. maximilian.wintergerst@ukbonn.de.; Augenzentrum Grischun, Chur, Switzerland. maximilian.wintergerst@ukbonn.de.; Department of Ophthalmology, University Hospital Bonn, Ernst-Abbe-Straße 2 |, 53127, Bonn, Germany. maximilian.wintergerst@ukbonn.de.

Πηγή: Scientific reports [Sci Rep] 2026 Jun 17; Vol. 16 (1). Date of Electronic Publication: 2026 Jun 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Tomography, Optical Coherence*/methods , Choroid*/pathology , Choroid*/diagnostic imaging , Uveitis, Intermediate*/diagnostic imaging , Uveitis, Intermediate*/pathology , Uveitis, Intermediate*/physiopathology , Visual Acuity*, Humans ; Female ; Male ; Prognosis ; Middle Aged ; Adult

Impaired postsynaptic function and disruption of intermediate filaments in GLAST-knockout-induced hidden hearing loss.

Συγγραφείς: Ma K; Military Medical Sciences Academy, Tianjin, China., Wang F; Military Medical Sciences Academy, Tianjin, China.; Tianjin University of Traditional Chinese Medicine, Tianjin, China., Song X; Military Medical Sciences Academy, Tianjin, China.; School of Public Health, Shandong Second Medical University, Weifang, China., Yang H; Military Medical Sciences Academy, Tianjin, China., Gao X; Military Medical Sciences Academy, Tianjin, China., Zhu Y; Military Medical Sciences Academy, Tianjin, China., Fu B; Military Medical Sciences Academy, Tianjin, China., She X; Military Medical Sciences Academy, Tianjin, China., Cui B; Military Medical Sciences Academy, Tianjin, China.

Πηγή: The FEBS journal [FEBS J] 2026 Jun; Vol. 293 (12), pp. 3470-3484. Date of Electronic Publication: 2025 Dec 26.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Hearing Loss, Hidden*/genetics , Hearing Loss, Hidden*/pathology , Hearing Loss, Hidden*/metabolism , Hearing Loss, Hidden*/physiopathology , Excitatory Amino Acid Transporter 1*/genetics , Excitatory Amino Acid Transporter 1*/deficiency , Intermediate Filaments*/metabolism , Intermediate Filaments*/pathology , Intermediate Filaments*/genetics , Synapses*/pathology , Synapses*/metabolism, Ear, Inner/metabolism ; Ear, Inner/pathology ; Animals ; Mice, Knockout ; Mice ; Aging ; Disease Models, Animal