A clinically compatible in vitro drug-screening platform identifies therapeutic vulnerabilities in primary cultures of brain metastases

Authors: Jeising, Sebastian, Nickel, Ann-Christin, Trübel, Johanna, Felsberg, Jörg, Picard, Daniel, Leprivier, Gabriel, Wolter, Marietta, Huynh, My Ky, Olivera, Marlene B., Kaulich, Kerstin, Häberle, Lena, Esposito, Irene, Klau, Gunnar W., Steinmann, Julia, Beez, Thomas, Rapp, Marion, Sabel, Michael, Dietrich, Sascha, Remke, Marc, Cornelius, Jan F., Reifenberger, Guido, Qin, Nan

Source: J Neurooncol

Subject Terms: Female [MeSH], Brain Neoplasms/secondary [MeSH], Spheroid cultures, Brain Neoplasms/genetics [MeSH], Humans [MeSH], Antineoplastic Agents/pharmacology [MeSH], Middle Aged [MeSH], Tumor Cells, Cultured [MeSH], Personalized medicine, Drug Screening Assays, Antitumor/methods [MeSH], High-Throughput Screening Assays/methods [MeSH], Male [MeSH], High-throughput drug screening, Research, Brain metastasis, Antineoplastic Agents/therapeutic use [MeSH], Brain Neoplasms/drug therapy [MeSH], Brain Neoplasms/pathology [MeSH], High-Throughput Nucleotide Sequencing [MeSH], Male, 0301 basic medicine, Brain Neoplasms, High-Throughput Nucleotide Sequencing, Antineoplastic Agents, Middle Aged, High-Throughput Screening Assays, 03 medical and health sciences, 0302 clinical medicine, Tumor Cells, Cultured, Humans, Female, Drug Screening Assays, Antitumor

Access URL: https://pubmed.ncbi.nlm.nih.gov/38985431
https://repository.publisso.de/resource/frl:6498549

Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans

Authors: René Geci, Domenico Gadaleta, Marina García de Lomana, Rita Ortega-Vallbona, Erika Colombo, Eva Serrano-Candelas, Alicia Paini, Lars Kuepfer, Stephan Schaller

Source: Arch Toxicol
Archives of toxicology 98(8), 2659-2676 (2024). doi:10.1007/s00204-024-03764-9
Archives of Toxicology

Subject Terms: 0301 basic medicine, 0303 health sciences, Administration, Oral, In Silico, Models, Biological, Humans [MeSH], Pharmaceutical Preparations/metabolism [MeSH], Computer Simulation [MeSH], Physiologically based kinetic (PBK) modelling, Models, Biological [MeSH], Animals [MeSH], New approach methodologies (NAMs), Administration, Oral [MeSH], Administration, Intravenous [MeSH], High-Throughput Screening Assays/methods [MeSH], Pharmaceutical Preparations/administration, Next-generation risk assessment (NGRA), Pharmacokinetics, Pharmacokinetics [MeSH], High-throughput PBK modelling, High-Throughput Screening Assays, 03 medical and health sciences, Pharmaceutical Preparations, Humans, Animals, Computer Simulation, Administration, Intravenous

Access URL: https://pubmed.ncbi.nlm.nih.gov/38722347
https://repository.publisso.de/resource/frl:6493820
https://publications.rwth-aachen.de/record/988041

DNA-methylation patterns imply a common cellular origin of virus- and UV-associated Merkel cell carcinoma

Authors: Jürgen C. Becker, Anja Lange, Andrzej A. Dlugosz, Daniel Hoffmann, Monique Verhaegen, Ivelina Spassova, Jan Gravemeyer

Source: Oncogene

Subject Terms: Carcinoma, Merkel Cell, 0301 basic medicine, Tumor Virus Infections, 0303 health sciences, 03 medical and health sciences, Carcinoma, Merkel Cell/genetics [MeSH], DNA Methylation/genetics [MeSH], Cancer of unknown primary, Article, High-Throughput Screening Assays/methods [MeSH], Humans [MeSH], Tumor Virus Infections/genetics [MeSH], High-throughput screening, Cancer genomics, Medizin, Humans, DNA Methylation, Biologie, High-Throughput Screening Assays, 3. Good health

Access URL: https://www.nature.com/articles/s41388-021-02064-1.pdf
https://pubmed.ncbi.nlm.nih.gov/34667274
https://www.nature.com/articles/s41388-021-02064-1
https://www.nature.com/articles/s41388-021-02064-1.pdf
https://inrepo01.inet.dkfz-heidelberg.de/record/177113?ln=de
https://pubmed.ncbi.nlm.nih.gov/34667274/?fc=None&ff=20211021030118&v=2.15.0
https://pubmed.ncbi.nlm.nih.gov/34667274/
https://repository.publisso.de/resource/frl:6443672
https://www.ncbi.nlm.nih.gov/pubmed/34667274
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85117303152
https://doi.org/10.1038/s41388-021-02064-1