Genetic intratumour heterogeneity in digestive high-grade neuroendocrine neoplasms.

Συγγραφείς: Morken S; Cancer Clinic, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Sorbye H; Cancer Clinic, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Deng W; Cancer Clinic, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Dogramaci HT; Cancer Clinic, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway., Venizelos A; Department of Clinical Science, University of Bergen, Bergen, Norway., Vestermark LW; Department of Oncology, University Hospital of Southern Denmark, Esbjerg, Denmark., Pfeiffer P; Department of Oncology, Odense University Hospital, Odense, Denmark., Hjortland GO; Department of Oncology, Oslo University Hospital, Oslo, Norway., Kersten C; Department of Research, Hospital of Southern Norway, Kristiansand, Norway., Hofsli E; Department of Oncology, St. Olavs Hospital, Trondheim, Norway., Elvebakken H; Department of Oncology, Ålesund Hospital, Møre og Romsdal Hospital Trust, Ålesund, Norway., Couvelard A; Pathology Department, Bichat Hospital AP-HP and Université Paris Cité, Paris, France., Lothe IMB; Department of Pathology, Oslo University Hospital, Oslo, Norway., Perren A; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Knappskog S; Cancer Clinic, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, University of Bergen, Bergen, Norway.

Πηγή: Journal of neuroendocrinology [J Neuroendocrinol] 2026 Oct; Vol. 38 (10), pp. e70296.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley & Sons Country of Publication: United States NLM ID: 8913461 Publication Model: Print Cited Medium: Internet ISSN: 1365-2826 (Electronic) Linking ISSN: 09538194 NLM ISO Abbreviation: J Neuroendocrinol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neuroendocrine Tumors*/genetics , Neuroendocrine Tumors*/pathology , Digestive System Neoplasms*/genetics , Digestive System Neoplasms*/pathology , Genetic Heterogeneity*, Humans ; Mutation ; Female ; Male ; Neoplasm Grading

Intraclonal heterogeneity in mature B-cell malignancies: The perspective of immunogenetics.

Συγγραφείς: Iatrou A; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece., Roussos A; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece; Department of Public and One Health, University of Thessaly, Karditsa, Greece., Chatzikonstantinou T; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece., Chatzidimitriou A; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Stamatopoulos K; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Electronic address: Kostas.stamatopoulos@certh.gr., Agathangelidis A; Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece; Department of Biology, School of Science, National and Kapodistrian University of Athens, Athens, Greece.

Πηγή: Seminars in cancer biology [Semin Cancer Biol] 2026 Oct; Vol. 126, pp. 102616. Date of Electronic Publication: 2026 Aug 22.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: England NLM ID: 9010218 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3650 (Electronic) Linking ISSN: 1044579X NLM ISO Abbreviation: Semin Cancer Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Immunogenetics*/methods , B-Lymphocytes*/immunology , B-Lymphocytes*/pathology , B-Lymphocytes*/metabolism , Leukemia, B-Cell*/genetics , Leukemia, B-Cell*/immunology , Leukemia, B-Cell*/pathology , Genetic Heterogeneity*, Receptors, Antigen, B-Cell/genetics ; Humans ; Animals

Investigation of evolutionary dynamics and genetic heterogeneity of Salmonella in persistent bacteremia.

Συγγραφείς: Yeh TK; Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Genomic Center for Infectious Diseases, Taichung Veterans General Hospital, Taichung, Taiwan., Huang YT; Department of Computer Science and Information Engineering, National Chung Cheng University, Chiayi, Taiwan. Electronic address: ythuang@cs.ccu.edu.tw., Liu PY; Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Genomic Center for Infectious Diseases, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan; Doctoral Program in Translational Medicine, Rong Hsing Translational Medicine Research Center, National Chung Hsing University, Taichung, Taiwan. Electronic address: liupoyu@gmail.com.

Πηγή: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2026 Oct; Vol. 144, pp. 105994. Date of Electronic Publication: 2026 Jul 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101084138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1567-7257 (Electronic) Linking ISSN: 15671348 NLM ISO Abbreviation: Infect Genet Evol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Bacteremia*/microbiology , Salmonella Infections*/microbiology , Salmonella*/genetics , Salmonella*/classification , Genetic Heterogeneity*, Humans ; Phylogeny ; Evolution, Molecular ; Polymorphism, Single Nucleotide ; Whole Genome Sequencing ; Genome, Bacterial

Epigenetic heterogeneity and plasticity in therapy-induced tumor states through single-cell multi-omics.

Συγγραφείς: Kim HJ; Ajou Energy Science Research Center, Ajou University, Suwon, Korea., Lee H; Department of Molecular Science and Technology, Ajou University, Suwon, Korea., Hong J; Department of Molecular Science and Technology, Ajou University, Suwon, Korea., Park D; Department of Molecular Science and Technology, Ajou University, Suwon, Korea.; College of Advanced Bio-Convergence Engineering, Ajou University, Suwon, Korea.

Πηγή: Molecular oncology [Mol Oncol] 2026 Oct; Vol. 20 (10), pp. 2424-2448. Date of Electronic Publication: 2026 Jun 04.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/therapy , Neoplasms*/drug therapy , Single-Cell Analysis*/methods , Cell Plasticity*/genetics , Epigenesis, Genetic* , Genetic Heterogeneity*, Humans ; Multiomics ; Animals ; Epithelial-Mesenchymal Transition

Genetic dissection of clinical heterogeneity in hemoglobin H patients by targeted long-read sequencing.

Συγγραφείς: Ye Y; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Niu C; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Mao A; Department of long-read sequencing research and development, Berry Genomics Corporation, Beijing 102200, China., Chen L; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Qin L; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Chen W; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Liu Z; Department of long-read sequencing research and development, Berry Genomics Corporation, Beijing 102200, China., Xie T; Department of long-read sequencing research and development, Berry Genomics Corporation, Beijing 102200, China., Long Y; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Shang X; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Huang Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Zhang Q; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Chen L; Department of long-read sequencing research and development, Berry Genomics Corporation, Beijing 102200, China., Luo H; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Li Y; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China., Lu Y; Department of long-read sequencing research and development, Berry Genomics Corporation, Beijing 102200, China., Liu Y; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Liao L; Department of Gynecology and Obstetrics, Technology Center of Prenatal Diagnosis and Genetic Diseases Diagnosis, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Cai J; Department of Gynecology and Obstetrics, Technology Center of Prenatal Diagnosis and Genetic Diseases Diagnosis, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Liu R; Department of Gynecology and Obstetrics, Technology Center of Prenatal Diagnosis and Genetic Diseases Diagnosis, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Zhang X; Department of Pediatrics, Huizhou Central People's Hospital, Huizhou, Guangdong 516001, China., Zeng L; Department of Pediatrics, Huizhou Central People's Hospital, Huizhou, Guangdong 516001, China., Li Y; Department of Hematology, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021, China., Chen J; Department of Pediatrics, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021, China., Zhong Z; Department of Pediatrics, 923(rd) Hospital of the People's Liberation Army, Nanning, Guangxi 530021, China., Fang J; Department of medical genetics and prenatal diagnosis, Huizhou First Maternal and Child Health Care Hospital, Guangdong 516000, China., Li X; Department of medical genetics and prenatal diagnosis, Huizhou First Maternal and Child Health Care Hospital, Guangdong 516000, China., Yang X; Department of Pediatric Hematology/Oncology, Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China., Lin B; The Affiliated Foshan Women and Children Hospital, Guangdong Medical University, Foshan, Guangdong 528000, China., Li K; The Affiliated Foshan Women and Children Hospital, Guangdong Medical University, Foshan, Guangdong 528000, China., Hua X; The Affiliated Foshan Women and Children Hospital, Guangdong Medical University, Foshan, Guangdong 528000, China., Huang B; Guangzhou Huayinkang Healthcare Group Co., Ltd., Guangzhou, Guangdong 510663, China., Qin H; Department of Internal Medicine, Sixth People's Hospital of Nanning, Nanning, Guangxi 530022, China., Huang Y; Department of Pediatrics, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China., Huang Z; Department of Pediatrics, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China., Lao J; Department of Pediatrics, Liuzhou Worker's Hospital, Liuzhou, Guangxi 545005, China., Qu X; Department of Pediatrics, Liuzhou Worker's Hospital, Liuzhou, Guangxi 545005, China., Chen J; Department of Pediatrics, The Second People's Hospital of Shenzhen, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, China., Feng X; Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Liu Q; Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Lin W; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Zhou X; Central Laboratory, Dongguan Songshan Lake Central Hospital, Dongguan, Guangdong 523808, China., Liang Y; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China., Long X; Department of Pediatrics, Liuzhou People's Hospital, Liuzhou, Guangxi 545001, China., Qin J; Department of Pediatrics, Liuzhou People's Hospital, Liuzhou, Guangxi 545001, China., Yan L; Medical Genetics Laboratory, Heyuan Maternal and Child Health Care Hospital, Heyuan, Guangdong 517000, China., Zhu W; Department of Hematology and Oncology, Zhuhai People's Hospital, The Third Affiliated Hospital, Jinan University Medical College, Zhuhai, Guangdong 519000, China., Yu L; Department of Hematology and Rheumatology, Longyan First Hospital, Affiliated to Fujian Medical University, Longyan, Fujian 364000, China., Fan C; Department of Pediatrics, Second People's Hospital of Guilin, Guilin, Guangxi 541001, China., Tang D; Department of Genetics and Laboratory Medicine, Maternal and Child Health Hospital of Yongzhou City, Yongzhou, Hunan 425000, China., Zhong T; Department of Clinical Laboratory, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi 341000, China., Tan J; Prenatal Diagnosis Center, Chenzhou First People's Hospital, Chenzhou, Hunan 423000, China., Ren Z; Department of long-read sequencing research and development, Berry Genomics Corporation, Beijing 102200, China., Gao Y; Department of long-read sequencing research and development, Berry Genomics Corporation, Beijing 102200, China., Xu X; Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China; Innovation Center for Diagnostics and Treatment of Thalassemia, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address: gzxuxm@pub.guangzhou.gd.cn.

Πηγή: Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2026 Oct; Vol. 53 (10), pp. 1873-1883. Date of Electronic Publication: 2026 Apr 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Science press Country of Publication: China NLM ID: 101304616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1673-8527 (Print) Linking ISSN: 16738527 NLM ISO Abbreviation: J Genet Genomics Subsets: MEDLINE

Ιατρικοί όροι (MeSH): alpha-Thalassemia*/genetics , alpha-Thalassemia*/pathology , Hemoglobin H*/genetics , Genetic Heterogeneity*, Haplotypes/genetics ; alpha-Globins/genetics ; beta-Globins/genetics ; beta-Thalassemia/genetics ; Nuclear Proteins/genetics ; Carrier Proteins/genetics ; Peptide Elongation Factors/genetics ; Proto-Oncogene Proteins c-myb/genetics ; Humans ; Mutation ; Female ; Repressor Proteins ; Phenotype ; Male ; Sequence Analysis, DNA ; GTP-Binding Proteins

Unveiling tumor heterogeneity by single cell RNA-sequencing: From basic considerations to clinical applications.

Συγγραφείς: Fuchs T; Institute of Pathology, Heidelberg University Hospital, Center for Personalized Medicine (ZPM), German Cancer Consortium (DKTK), Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany. Electronic address: tina.fuchs@med.uni-heidelberg.de., Menzel M; Institute of Pathology, Heidelberg University Hospital, Center for Personalized Medicine (ZPM), German Cancer Consortium (DKTK), Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Mößinger K; NGS Core Facility, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Kazdal D; Institute of Pathology, Heidelberg University Hospital, Center for Personalized Medicine (ZPM), German Cancer Consortium (DKTK), Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Kahles A; Institute of Pathology, Heidelberg University Hospital, Center for Personalized Medicine (ZPM), German Cancer Consortium (DKTK), Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Budczies J; Institute of Pathology, Heidelberg University Hospital, Center for Personalized Medicine (ZPM), German Cancer Consortium (DKTK), Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Stenzinger A; Institute of Pathology, Heidelberg University Hospital, Center for Personalized Medicine (ZPM), German Cancer Consortium (DKTK), Translational Lung Research Center (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.

Πηγή: Seminars in cancer biology [Semin Cancer Biol] 2026 Sep; Vol. 125, pp. 20-33. Date of Electronic Publication: 2026 Jun 28.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: England NLM ID: 9010218 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3650 (Electronic) Linking ISSN: 1044579X NLM ISO Abbreviation: Semin Cancer Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Single-Cell Analysis*/methods , Neoplasms*/genetics , Neoplasms*/pathology , Biomarkers, Tumor*/genetics , Sequence Analysis, RNA*/methods , Genetic Heterogeneity*, Tumor Microenvironment/genetics ; Humans ; Single-Cell Gene Expression Analysis ; Animals ; Transcriptome

Fusion gene heterogeneity and kinase enrichment in high-grade serous carcinomas.

Συγγραφείς: Panagopoulos I; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: ioapan@ous-hf.no., Stranger A; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: ane.stranger@ous-research.no., Sveen A; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: anita.sveen@medisin.uio.no., Jareid M; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: mielinn@gmail.com., Kidd SG; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: s.g.kidd@ous-research.no., Bischof K; Department of Surgical Oncology, Section of Gynaecological Oncology, Oslo University Hospital-Radiumhospitalet, Oslo, Norway; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: katbis@ous-hf.no., Taskén K; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: kjetil.tasken@medisin.uio.no., Dørum A; Department of Surgical Oncology, Section of Gynaecological Oncology, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: dorumanne@gmail.com., Davidson B; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Pathology, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: ben.davidson@medisin.uio.no., Lothe RA; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: r.a.lothe@medisin.uio.no., Skotheim RI; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway; Department of Informatics, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway. Electronic address: rolfis@uio.no., Johannessen B; Department of Molecular Oncology, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway. Electronic address: bjarnej@uio.no.

Πηγή: Neoplasia (New York, N.Y.) [Neoplasia] 2026 Sep; Vol. 79, pp. 101332. Date of Electronic Publication: 2026 Jun 25.

Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 100886622 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5586 (Electronic) Linking ISSN: 14765586 NLM ISO Abbreviation: Neoplasia Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cystadenocarcinoma, Serous*/genetics , Cystadenocarcinoma, Serous*/pathology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Oncogene Proteins, Fusion*/genetics , Protein Kinases*/genetics , Genetic Heterogeneity*, Biomarkers, Tumor/genetics ; Humans ; Female ; Neoplasm Grading

Understanding tumor heterogeneity: Implications for precision oncology and therapeutic strategies.

Συγγραφείς: Lv Y; Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China., He C; Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China., Xie Q; Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China., Long F; Division of Gastrointestinal, Bariatric and Metabolic Surgery, Department of General Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Electronic address: longfw1978@sina.com., Fan C; Division of Gastrointestinal, Bariatric and Metabolic Surgery, Department of General Surgery, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China; Department of Oncology and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. Electronic address: chuanwen.fan@liu.se.

Πηγή: Biochimica et biophysica acta. Reviews on cancer [Biochim Biophys Acta Rev Cancer] 2026 Sep; Vol. 1881 (4), pp. 189617. Date of Electronic Publication: 2026 May 27.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9806362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2561 (Electronic) Linking ISSN: 0304419X NLM ISO Abbreviation: Biochim Biophys Acta Rev Cancer Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Precision Medicine*/methods , Neoplasms*/genetics , Neoplasms*/pathology , Neoplasms*/therapy , Neoplasms*/drug therapy , Genetic Heterogeneity*, Tumor Microenvironment/genetics ; Drug Resistance, Neoplasm/genetics ; Biomarkers, Tumor/genetics ; Medical Oncology/methods ; Humans ; Multiomics

Transcriptional Heterogeneity Underlying Cancer Cell Migration Converges on Shared Regulatory Programs.

Συγγραφείς: Ortiz I; Department of Bioengineering, Rice University, Houston, TX 77005, USA., Taufalele PV; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA., Dunagan VL; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA., Hodge SS; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA., Wang J; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Liu Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Reinhart-King CA; Department of Bioengineering, Rice University, Houston, TX 77005, USA.

Πηγή: Genes [Genes (Basel)] 2026 Aug 29; Vol. 17 (9). Date of Electronic Publication: 2026 Aug 29.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cell Movement*/genetics , Neoplasms*/genetics , Neoplasms*/pathology , Gene Expression Regulation, Neoplastic* , Genetic Heterogeneity*, Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Muscle Proteins/genetics ; Muscle Proteins/metabolism ; Melanoma/genetics ; Melanoma/pathology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Humans ; Cell Line, Tumor ; TEA Domain Transcription Factors ; Female

Exploring Intratumor Heterogeneity in Cancer: A Comparative Evaluation of Clustering Methods.

Συγγραφείς: Ribeiro PH; Federal Institute of São Paulo, Barretos, Brazil., Simao ADS; University of São Paulo, São Carlos, Brazil.

Πηγή: Journal of computational biology : a journal of computational molecular cell biology [J Comput Biol] 2026 Aug; Vol. 33 (8), pp. 787-803. Date of Electronic Publication: 2026 May 12.

Τύπος έκδοσης: Journal Article; Comparative Study

Στοιχεία περιοδικού: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 9433358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8666 (Electronic) Linking ISSN: 10665277 NLM ISO Abbreviation: J Comput Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/genetics , Computational Biology*/methods , Genetic Heterogeneity*, Clustering Algorithms ; Humans ; Algorithms ; Cluster Analysis ; Mutation ; Bayes Theorem ; Gene Frequency

Epigenetic heterogeneity in women with polycystic ovary syndrome.

Συγγραφείς: Wang A; Department of Reproductive Medicine, Linyi People's Hospital, Linyi, 276000, China; Key Laboratory for Assisted Reproduction and Offspring Health of Linyi City, Linyi, 276000, China. Electronic address: ancongw12@163.com., Liu M; Department of Reproductive Medicine, Linyi People's Hospital, Linyi, 276000, China; Key Laboratory for Assisted Reproduction and Offspring Health of Linyi City, Linyi, 276000, China. Electronic address: doctorliumin@163.com., Li W; School of AI, Jilin International Studies University, Changchun, 130117, China. Electronic address: weilonglicn@outlook.com., Zhu D; Department of Reproductive Medicine, Weihai Women and Children's Hospital, Weihai, 264299, China. Electronic address: zdongyi1962@126.com., Tan Q; Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, 5230, Odense, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, 5230, Odense, Denmark. Electronic address: qtan@health.sdu.dk.

Πηγή: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2026 Aug; Vol. 618, pp. 112807. Date of Electronic Publication: 2026 Apr 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: North Holland Publishing Country of Publication: Ireland NLM ID: 7500844 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8057 (Electronic) Linking ISSN: 03037207 NLM ISO Abbreviation: Mol Cell Endocrinol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Polycystic Ovary Syndrome*/genetics , Epigenesis, Genetic* , Genetic Heterogeneity*, DNA Methylation/genetics ; CpG Islands/genetics ; Humans ; Female ; Genome-Wide Association Study ; Case-Control Studies ; Cluster Analysis

The molecular heterogeneity and clinical impact of genomic driver alterations in prostate cancer.

Συγγραφείς: Pellegrina D; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Kiriy D; Biotech Research & Innovation Centre (BRIC)-University of Copenhagen, Copenhagen, Denmark.; Finsen Laboratory, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., C L Cheng K; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Favero F; Biotech Research & Innovation Centre (BRIC)-University of Copenhagen, Copenhagen, Denmark.; Finsen Laboratory, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Miletti E; Biotech Research & Innovation Centre (BRIC)-University of Copenhagen, Copenhagen, Denmark.; Finsen Laboratory, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Klein ZP; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Hernando B; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Olsen AV; Biotech Research & Innovation Centre (BRIC)-University of Copenhagen, Copenhagen, Denmark.; Finsen Laboratory, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Sahli A; Manchester Cancer Research Centre, The University of Manchester, Manchester, UK., Fu Y; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia., Lutsik P; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Oncology, KU Leuven, Leuven, Belgium., Jaratlerdsiri W; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia., Hutchison WJ; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia., Bova GS; Prostate Cancer Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Brewer DS; Department of Metabolic Health, Norwich Medical School, University of East Anglia, Norwich, UK.; The Earlham Institute, Norwich Research Park, Norwich, UK., Brook M; The Institute of Cancer Research, London, UK., Brors B; Division Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Core Center Heidelberg, and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Medical Faculty Heidelberg and Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Butler A; Wellcome Sanger Institute, Cambridge, UK., Cancel-Tassin G; CeRePP (Centre de Recherche sur les Pathologies Prostatiques et Urologiques), Paris, France.; GRC n°5 Predictive Onco-Urology, APHP, Tenon Hospital, Sorbonne Université, Paris, France., Corcoran NM; Department of Urology, Royal Melbourne Hospital, Parkville, VIC, Australia.; Department of Surgery, The University of Melbourne, Parkville, VIC, Australia.; Department of Urology, Western Health, Victoria, Australia., Cussenot O; CeRePP (Centre de Recherche sur les Pathologies Prostatiques et Urologiques), Paris, France., Gihawi A; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.; Norwich Medical School, University of East Anglia, Norwich, UK., Girma EG; Biotech Research & Innovation Centre (BRIC)-University of Copenhagen, Copenhagen, Denmark.; Finsen Laboratory, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Gnanapragasam VJ; Department of Surgery, Urology, University of Cambridge & Cambridge University Hospitals NHS Trust, Cambridge Urology Translational Research and Clinical Trials (Office), Cambridge Biomedical Campus, Addenbrooke's Hospital Site, Cambridge, UK., Hamid AA; Department of Surgery, The University of Melbourne, Parkville, VIC, Australia., He HH; Department of Medical Biophysics, Princess Margaret Cancer Centre, University Health Network; University of Toronto, Toronto, ON, Canada., Imada ELL; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Jakobsdottir GM; Division of Cancer Sciences, The University of Manchester, Manchester, UK.; Christie Hospital, The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Jung CH; Melbourne Bioinformatics, The University of Melbourne, Parkville, VIC, Australia., Khani F; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Kote-Jarai Z; The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK., Lamy P; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Leeman G; Wellcome Sanger Institute, Cambridge, UK., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Molania R; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia., Queiroz LR; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Rausch T; Genome Biology, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany., Robinson B; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Sørensen KD; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Uhrig S; Division Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Xu Y; Wellcome Sanger Institute, Cambridge, UK., Yamaguchi TN; Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA, USA., Zanettini C; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Mangiola S; Adelaide University, Adelaide, SA, Australia., Voith von Voithenberg L; German Cancer Research Center (DKFZ), Heidelberg, Germany., Marchionni L; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Papenfuss AT; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, The University of Melbourne, Melbourne, VIC, Australia., Pope B; Department of Surgery, The University of Melbourne, Parkville, VIC, Australia.; Melbourne Bioinformatics, The University of Melbourne, Bedford Street, North Melbourne, Victoria, Australia.; Australian BioCommons, The University of Melbourne, North Melbourne, VIC, Australia., Hayes VM; Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, Australia.; Norwich Medical School, University of East Anglia, Norwich, UK.; Manchester Cancer Research Centre, University of Manchester, Manchester, UK.; School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa., Schlomm T; Department of Urology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Bristow RG; Manchester Cancer Research Centre and Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK.; Christie NHS Foundation Trust, Manchester, UK.; Div Cancer Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK., Hovens CM; Department of Surgery, The Collaborative Centre for Genomic Cancer Medicine, The University of Melbourne, Parkville, VC, Australia., Eeles RA; The Institute of Cancer Research, London, UK.; The Royal Marsden NHS Foundation Trust, London, UK., Cooper CS; Norwich Medical School, University of East Anglia, Norwich, UK., Gerhauser C; German Cancer Research Center (DKFZ), Heidelberg, Germany., Macintyre G; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Gruber AJ; University of Konstanz, Konstanz, Germany., Wedge DC; Manchester Cancer Research Centre, The University of Manchester, Manchester, UK., Weischenfeldt J; Biotech Research & Innovation Centre (BRIC)-University of Copenhagen, Copenhagen, Denmark. joachim.weischenfeldt@bric.ku.dk.; Finsen Laboratory, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. joachim.weischenfeldt@bric.ku.dk.; Department of Urology, Charité-Universitätsmedizin Berlin, Berlin, Germany. joachim.weischenfeldt@bric.ku.dk., Reimand J; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada. juri.reimand@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. juri.reimand@utoronto.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. juri.reimand@utoronto.ca.

Συλλογικό Έργο: Pan Prostate Cancer Group

Πηγή: Nature communications [Nat Commun] 2026 Oct 16; Vol. 17 (1). Date of Electronic Publication: 2026 Oct 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/mortality , Genetic Heterogeneity*, Hepatocyte Nuclear Factor 3-alpha/genetics ; Oncogenes/genetics ; Humans ; Male ; DNA Copy Number Variations ; Gene Expression Regulation, Neoplastic ; Mutation ; Genomics ; Whole Genome Sequencing

CDState Resolves Malignant Cell Heterogeneity from Bulk Tumor RNA Sequencing Data.

Συγγραφείς: Kraft A; Department of Computer Science, Institute for Machine Learning, ETH Zurich, Zürich, Switzerland.; Department of Thoracic Surgery, University Hospital Zurich, Zürich, Switzerland.; SIB, Swiss Institute of Bioinformatics, Lausanne, Switzerland., Yates J; Department of Computer Science, Institute for Machine Learning, ETH Zurich, Zürich, Switzerland.; SIB, Swiss Institute of Bioinformatics, Lausanne, Switzerland.; ETH AI Center, ETH Zurich, Zürich, Switzerland., Barkmann F; Department of Computer Science, Institute for Machine Learning, ETH Zurich, Zürich, Switzerland.; SIB, Swiss Institute of Bioinformatics, Lausanne, Switzerland.; ETH AI Center, ETH Zurich, Zürich, Switzerland., Boeva V; Department of Computer Science, Institute for Machine Learning, ETH Zurich, Zürich, Switzerland.; SIB, Swiss Institute of Bioinformatics, Lausanne, Switzerland.; ETH AI Center, ETH Zurich, Zürich, Switzerland.

Πηγή: Cancer research [Cancer Res] 2026 Oct 15; Vol. 86 (20), pp. 5023-5042.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/genetics , Neoplasms*/pathology , Sequence Analysis, RNA*/methods , Computational Biology*/methods , Genetic Heterogeneity*, Gene Expression Profiling/methods ; Humans ; Single-Cell Gene Expression Analysis ; Gene Expression Regulation, Neoplastic ; Transcriptome

Clonal lineage tracing and parallel multiomics profiling reveal transcriptional heterogeneity induced by ARID1A deficiency.

Συγγραφείς: Miyata K; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.; Cancer Cell Communication Project, NEXT-Ganken Program, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan., Yang L; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan., Yang Y; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan., Kumegawa K; Cancer Cell Diversity Project, NEXT-Ganken Program, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan., Maruyama R; Division of Cancer Epigenomics, Cancer Institute, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.; Cancer Cell Diversity Project, NEXT-Ganken Program, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan.

Πηγή: Science advances [Sci Adv] 2026 Oct 09; Vol. 12 (41), pp. eaed7880. Date of Electronic Publication: 2026 Oct 07.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Transcription Factors*/deficiency , Transcription Factors*/genetics , DNA-Binding Proteins*/deficiency , DNA-Binding Proteins*/genetics , Cell Lineage*/genetics , Genetic Heterogeneity* , Transcription, Genetic*, Multiomics ; Animals ; Humans ; Gene Expression Profiling ; Single-Cell Gene Expression Analysis ; Gene Expression Regulation, Neoplastic ; Single-Cell Analysis

Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity.

Συγγραφείς: Fagniez I; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Tsumura M; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Guérin A; Garvan Institute of Medical Research , Sydney, Australia.; Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, Australia., Abolhassani H; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children´s Medical Center, Tehran University of Medical Sciences , Tehran, Iran., Sharafian S; Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mesdaghi M; Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Nishimura T; Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki City, Japan., Lashkari HP; Department of Pediatrics, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India., Rao S; Department of Surgery, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India., Richards S; Allergy & Immunology, Royal Children's Hospital, Melbourne, Australia., Han JE; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Delmonte OM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Kergaravat C; Institut de Recherche Saint Louis, INSERM UMR 1342, Université Paris Cité , Paris, France., Markle JG; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Ogishi M; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Han J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Peel J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Vellutini J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Feng Y; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA., Soudée C; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France., Migaud M; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France., Palterer B; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Jackson KJL; Garvan Institute of Medical Research , Sydney, Australia., Nishimura S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Sakata S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Kinoshita K; Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Yamamoto A; Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki City, Japan., Moritake H; Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki City, Japan., Alzahrani M; Department of Pediatrics, Security Forces Hospital, Riyadh, Saudi Arabia., Vallejos F; Division of Pediatric Immunology, Gustavo Fricke Hospital, Valparaiso, Chile., Cole T; Allergy & Immunology, Royal Children's Hospital, Melbourne, Australia., Smart JM; Allergy & Immunology, Royal Children's Hospital, Melbourne, Australia., Choo S; Allergy & Immunology, Royal Children's Hospital, Melbourne, Australia., Chavoshzadeh Z; Department of Allergy and Clinical Immunology, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Armin S; Pediatric Infections Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences , Tehran, Iran., Toubert A; Institut de Recherche Saint Louis, INSERM UMR 1342, Université Paris Cité , Paris, France., Zhang P; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France., Rosain J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Pan-Hammarström Q; Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden., Tangye SG; Garvan Institute of Medical Research , Sydney, Australia.; Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, Australia., Casanova JL; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France.; Department of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France.; Howard Hughes Medical Institute , New York, NY, USA., Ma CS; Garvan Institute of Medical Research , Sydney, Australia.; Faculty of Medicine and Health, School of Clinical Medicine, UNSW Sydney, Sydney, Australia., Puel A; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France., Bustamante J; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France.; Study Center for Primary Immunodeficiencies, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP) , Paris, France., Okada S; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan., Boisson-Dupuis S; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.; Imagine Institute, Université Paris Cité , Paris, France., Yang R; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.; Department of Pediatrics, Division of Immunology, Allergy, and Retrovirology, Baylor College of Medicine, Houston, TX, USA.; William T. Shearer Center for Human Immunobiology, Texas Children's Hospital , Houston, TX, USA.

Πηγή: The Journal of experimental medicine [J Exp Med] 2026 Oct 05; Vol. 223 (10). Date of Electronic Publication: 2026 Sep 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Nuclear Receptor Subfamily 1, Group F, Member 3*/deficiency , Nuclear Receptor Subfamily 1, Group F, Member 3*/genetics , Candidiasis, Chronic Mucocutaneous*/genetics , Candidiasis, Chronic Mucocutaneous*/immunology , T-Lymphocytes*/immunology , Genetic Heterogeneity*, Mycobacterium Infections/genetics ; Mycobacterium Infections/immunology ; Killer Cells, Natural/immunology ; Humans ; Male ; Female ; Child ; Child, Preschool ; Adolescent ; Young Adult

The impact of intratumor heterogeneity on outcome and resistance to therapy in primary breast cancer: a systematic review.

Συγγραφείς: Dianati A; Department of Radiation Oncology (Maastro), GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands. aria.dianati@maastrichtuniversity.nl.; Department of Epidemiology, NUTRIM School of Nutrition and Translational Research in Metabolism, , Maastricht University, Maastricht, The Netherlands. aria.dianati@maastrichtuniversity.nl., Dekker A; Department of Radiation Oncology (Maastro), GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands., Wesselius A; Department of Epidemiology, NUTRIM School of Nutrition and Translational Research in Metabolism, , Maastricht University, Maastricht, The Netherlands., Wee L; Department of Radiation Oncology (Maastro), GROW Research Institute for Oncology and Reproduction, Maastricht University Medical Centre, Maastricht, The Netherlands.

Πηγή: Medical oncology (Northwood, London, England) [Med Oncol] 2026 Oct 03; Vol. 43 (11). Date of Electronic Publication: 2026 Oct 03.

Τύπος έκδοσης: Journal Article; Systematic Review

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Drug Resistance, Neoplasm*/genetics , Genetic Heterogeneity*, Humans ; Female ; Radiomics

Transcriptional Heterogeneity in Dedifferentiated Liposarcoma Reveals Distinct Cell-Cycle Subtypes.

Συγγραφείς: Herremans KM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Haase S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bailey LE; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wolff SC; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Purvis JE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Spanheimer PM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Zikry TM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. tarek@unc.edu.; Computational Medicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. tarek@unc.edu.; School of Data and Information Sciences, University of North Carolina, Chapel Hill, NC, USA. tarek@unc.edu.

Πηγή: Annals of surgical oncology [Ann Surg Oncol] 2026 Oct; Vol. 33 (10), pp. 9442-9450. Date of Electronic Publication: 2026 Jul 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cyclin-Dependent Kinase 4*/genetics , Cyclin-Dependent Kinase 4*/metabolism , Cyclin-Dependent Kinase 4*/antagonists & inhibitors , Liposarcoma*/genetics , Liposarcoma*/pathology , Liposarcoma*/classification , Liposarcoma*/metabolism , Cell Cycle*/genetics , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism , Genetic Heterogeneity*, Cyclin-Dependent Kinase 6/genetics ; Cyclin-Dependent Kinase 6/antagonists & inhibitors ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; Humans ; Gene Expression Regulation, Neoplastic ; Gene Expression Profiling

Parsing heterogeneity in autism spectrum disorder.

Συγγραφείς: Martín JM; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Geschwind DH; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; Institute for Precision Health, University of California Los Angeles, Los Angeles, CA, USA.

Πηγή: Science (New York, N.Y.) [Science] 2026 Sep 17; Vol. 393 (6817), pp. 1188-1189. Date of Electronic Publication: 2026 Sep 17.

Τύπος έκδοσης: News; Comment

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Autism Spectrum Disorder*/genetics , Autism Spectrum Disorder*/physiopathology , Genetic Heterogeneity*, Humans ; Mutation

Donor-Type-Dependent Heterogeneity of Ischemia-Reperfusion Injury in Lung Transplantation: A Multi-Cohort Transcriptomic Interaction Analysis of DCD Versus DBD Lungs.

Συγγραφείς: Ji Z; Department of Pathology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China., Peng Y; Department of Integrative Chinese and Western Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China., Wang L; Department of Integrative Chinese and Western Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, China.

Πηγή: Genes [Genes (Basel)] 2026 Sep 16; Vol. 17 (9). Date of Electronic Publication: 2026 Sep 16.

Τύπος έκδοσης: Comparative Study; Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Lung Transplantation*/adverse effects , Lung Transplantation*/methods , Reperfusion Injury*/genetics , Reperfusion Injury*/immunology , Tissue Donors*/statistics & numerical data , Primary Graft Dysfunction*/genetics , Primary Graft Dysfunction*/immunology , Genetic Heterogeneity*, Transcriptome/genetics ; Transcriptome/immunology ; Regulated Cell Death/genetics ; Regulated Cell Death/immunology ; Metabolic Networks and Pathways/genetics ; Metabolic Networks and Pathways/immunology ; Lung/immunology ; Transplants/immunology ; Gene Expression Profiling ; Warm Ischemia ; Predictive Learning Models ; Humans ; Death

Genetic Heterogeneity of Inborn Errors of Immunity Revealed by Whole-Genome Sequencing: Insights from a Russian Patient Cohort.

Συγγραφείς: Petrusenko Y; Biotech Campus LLC., 117437 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia., Savin T; Saint Petersburg Pasteur Institute, 197101 St. Petersburg, Russia.; Department of Immunology, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, Russia., Sedykh A; Saint Petersburg Pasteur Institute, 197101 St. Petersburg, Russia., Chekanov N; Biotech Campus LLC., 117437 Moscow, Russia., Klimuk E; Biotech Campus LLC., 117437 Moscow, Russia., Ostankova Y; Saint Petersburg Pasteur Institute, 197101 St. Petersburg, Russia., Kuznetsova R; Saint Petersburg Pasteur Institute, 197101 St. Petersburg, Russia.; Department of Immunology, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, Russia., Chernyshova A; Saint Petersburg Pasteur Institute, 197101 St. Petersburg, Russia., Milichkina A; Saint Petersburg Pasteur Institute, 197101 St. Petersburg, Russia., Totolian A; Saint Petersburg Pasteur Institute, 197101 St. Petersburg, Russia.; Department of Immunology, Pavlov First Saint Petersburg State Medical University, 197022 St. Petersburg, Russia., Severinov K; Biotech Campus LLC., 117437 Moscow, Russia.

Πηγή: International journal of molecular sciences [Int J Mol Sci] 2026 Sep 05; Vol. 27 (17). Date of Electronic Publication: 2026 Sep 05.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Whole Genome Sequencing*/methods , Agammaglobulinemia*/genetics , Genetic Heterogeneity*, Common Variable Immunodeficiency/genetics ; Agammaglobulinaemia Tyrosine Kinase/genetics ; Genetic Diseases, X-Linked/genetics ; Humans ; Male ; Female ; Russia ; Phenotype ; Cross-Sectional Studies ; Child, Preschool ; Child ; Cohort Studies ; Mutation

SCR Disease Name: Bruton type agammaglobulinemia