Small molecules restore mutant mitochondrial DNA polymerase activity

Authors: Valenzuela, S, Author, Zhu, X, Author, Macao, B, Author, Stamgren, M, Author, Geukens, C, Author, Charifson, PS, Author, Kern, G, Author, Hoberg, E, Author, Jenninger, L, Author, Gruszczyk, AV, Author

Contributors: Valenzuela, S, Author, Zhu, X, Author, Macao, B, Author, Stamgren, M, Author, Geukens, C, Author, Charifson, PS, Author, Kern, G, Author, Hoberg, E, Author, Jenninger, L, Author, Gruszczyk, AV, Author

Source: NATURE. 642(8067):501-507

Access URL: https://ki.se/en/research/search-research-information?t=2&query=id%3A1022037

Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia–reperfusion injury in kidney transplantation models

Authors: Hamed, M, Logan, A, Gruszczyk, AV, Beach, TE, James, AM, Dare, AJ, Barlow, A, Martin, J, Georgakopoulos, N, Gane, AM, Crick, K, Fouto, D, Fear, C, Thiru, S, Dolezalova, N, Ferdinand, Clatworthy, MR, Hosgood, SA, Nicholson, ML, Murphy, MP, Saeb-Parsy, K

Contributors: DSpace at Cambridge pro (8.1)

Source: British Journal of Surgery. 108:1072-1081

Subject Terms: 2. Zero hunger, 0301 basic medicine, 0303 health sciences, Swine, Ubiquinone, Organ Preservation, Kidney, Kidney Transplantation, Antioxidants, 3. Good health, Disease Models, Animal, 03 medical and health sciences, Organophosphorus Compounds, Reperfusion Injury, Animals, Humans

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/33963377

Assessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease

Authors: Jones, RE, Gruszczyk, AV, Schmidt, C, Hammersley, DJ, Mach, L, Lee, M, Wong, J, Yang, M, Hatipoglu, S, Lota, AS, Barnett, SN, Toscano-Rivalta, R, Owen, R, Raja, S, De Robertis, F, Smail, H, De-Souza, A, Stock, U, Kellman, P, Griffin, J, Dumas, M-E, Martin, JL, Saeb-Parsy, K, Vazir, A, Cleland, JGF, Pennell, DJ, Bhudia, SK, Halliday, BP, Noseda, M, Frezza, C, Murphy, MP, Prasad, SK

Source: 745 ; 733

Relation: Nature Cardiovascular Research; http://hdl.handle.net/10044/1/106077

Availability: http://hdl.handle.net/10044/1/106077
https://doi.org/10.1038/s44161-023-00312-z

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury

Authors: Beach, TE, Prag, HA, Pala, L, Logan, A, Huang, MM, Gruszczyk, AV, Martin, JL, Mahbubani, K, Hamed, MO, Hosgood, SA, Nicholson, ML, James, AM, Hartley, RC, Murphy, MP, Saeb-Parsy, K

Subject Terms: Ischemia reperfusion injury, Kidney, Malonate, Mitochondria, Succinate, Succinate dehydrogenase, Animals, Esters, Humans, Malonates, Mice, Prodrugs, Reperfusion Injury, Swine

File Description: application/pdf

Relation: https://www.repository.cam.ac.uk/handle/1810/308586

Availability: https://www.repository.cam.ac.uk/handle/1810/308586
https://doi.org/10.17863/CAM.55673

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly

Authors: Hinchy, EC, Gruszczyk, AV, Willows, R, Navaratnam, N, Hall, AR, Bates, G, Bright, TP, Krieg, T, Carling, D, Murphy, MP

Source: 17217 ; 17208

Subject Terms: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, AMP-activated kinase (AMPK), reactive oxygen species (ROS), mitochondria, hydrogen peroxide, redox signaling, HYDROGEN-PEROXIDE, ENERGY SENSOR, REPERFUSION INJURY, MECHANISMS, PEROXIREDOXIN, CELLS, HOMEOSTASIS, STRESS, MUSCLE, ADP, 06 Biological Sciences, 11 Medical And Health Sciences, 03 Chemical Sciences

Relation: JOURNAL OF BIOLOGICAL CHEMISTRY; http://hdl.handle.net/10044/1/64538; https://dx.doi.org/10.1074/jbc.RA118.002579

Availability: http://hdl.handle.net/10044/1/64538
https://doi.org/10.1074/jbc.RA118.002579

Mechanism of succinate efflux upon reperfusion of the ischemic heart.

Authors: Prag, HA, Gruszczyk, AV, Huang, MM, Beach, TE, Young, T, Tronci, L, Nikitopoulou, E, Mulvey, JF, Ascione, R, Hadjihambi, A, Shattock, MJ, Pellerin, L, Saeb-Parsy, K, Frezza, C, James, AM, Krieg, T, Murphy, MP, Aksentijević, D

Subject Terms: Ischemia/reperfusion injury, MCT1 transporter, Mitochondria, SUCNR1, Succinate

Relation: Cardiovasc Res; https://qmro.qmul.ac.uk/xmlui/handle/123456789/66287

Availability: https://qmro.qmul.ac.uk/xmlui/handle/123456789/66287
https://doi.org/10.1093/cvr/cvaa148

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Authors: Taylor, JC, Martin, HC, Lise, S, Broxholme, J, Cazier, J-B, Rimmer, A, Kanapin, A, Lunter, G, Fiddy, S, Allan, C, Aricescu, AR, Attar, M, Babbs, C, Becq, J, Beeson, D, Bento, C, Bignell, P, Blair, E, Buckle, VJ, Bull, K, Cais, O, Cario, H, Chapel, H, Copley, RR, Cornall, R, Craft, J, Dahan, K, Davenport, EE, Dendrou, C, Devuyst, O, Fenwick, AL, Flint, J, Fugger, L, Gilbert, RD, Goriely, A, Green, A, Greger, IH, Grocock, R, Gruszczyk, AV, Hastings, R, Hatton, E, Higgs, D, Hill, A, Holmes, C, Howard, M, Hughes, L, Humburg, P, Johnson, D, Karpe, F, Kingsbury, Z, Kini, U, Knight, JC, Krohn, J, Lamble, S, Langman, C, Lonie, L, Luck, J, McCarthy, D, McGowan, SJ, McMullin, MF, Miller, KA, Murray, L, Nemeth, AH, Nesbit, MA, Nutt, D, Ormondroyd, E, Oturai, AB, Pagnamenta, A, Patel, SY, Percy, M, Petousi, N, Piazza, P, Piret, SE, Polanco-Echeverry, G, Popitsch, N, Powrie, F, Pugh, C, Quek, L, Robbins, PA, Robson, K, Russo, A, Sahgal, N, Van Schouwenburg, PA, Schuh, A, Silverman, E, Simmons, A, Sorensen, PS, Sweeney, E, Taylor, J, Thakker, RV, Tomlinson, I, Trebes, A, Twigg, SRF, Uhlig, HH, Vyas, P, Vyse, T, Wall, SA, Watkins, H, Whyte, MP, Witty, L, Wright, B, Yau, C, Buck, D, Humphray, S, Ratcliffe, PJ, Bell, JI, Wilkie, AOM, Bentley, D, Donnelly, P, McVean, G

Source: 726 ; 717

Subject Terms: Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, LONG-QT SYNDROME, JUVENILE MYELOMONOCYTIC LEUKEMIA, SEVERE INTELLECTUAL DISABILITY, DISEASE GENE-DISCOVERY, OVARIAN-CANCER, GERMLINE MUTATIONS, BREAST-CANCER, HEREDITARY BREAST, CANDIDATE GENES, EXOME, Base Sequence, DNA Mutational Analysis, Genetic Diseases, Inborn, Genome, Human, High-Throughput Nucleotide Sequencing, Humans, Molecular Diagnostic Techniques, Molecular Sequence Annotation, Polymorphism, Single Nucleotide, Sensitivity and Specificity, Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences

Relation: Nature Genetics; http://hdl.handle.net/10044/1/32124; http://dx.doi.org/10.1038/ng.3304

Availability: http://hdl.handle.net/10044/1/32124
https://doi.org/10.1038/ng.3304

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation.

Authors: Casey AM; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Ryan DG; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Prag HA; Department of Medicine, University of Cambridge, Cambridge, UK., Chowdhury SR; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Marques E; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Turner K; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Gruszczyk AV; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK.; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK., Yang M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.; University of Cologne, Faculty of Mathematics and Natural Sciences, Institute of Genetics, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Wolf DM; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Miljkovic JL; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Valadares J; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Chinnery PF; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Hartley RC; WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK., Frezza C; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Metabolomics in Ageing, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany.; University of Cologne, Faculty of Mathematics and Natural Sciences, Institute of Genetics, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany., Prudent J; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK., Murphy MP; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, UK. mpm@mrc-mbu.cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. mpm@mrc-mbu.cam.ac.uk.

Source: Nature metabolism [Nat Metab] 2025 Mar; Vol. 7 (3), pp. 493-507. Date of Electronic Publication: 2025 Feb 19.

Publication Type: Journal Article

Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE

MeSH Terms: NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism , Macrophages*/metabolism , Interleukin-1beta*/metabolism , Inflammasomes*/metabolism , Superoxides*/metabolism , Mitochondria*/metabolism , Electron Transport Complex I*/metabolism, Reactive Oxygen Species/metabolism ; Lipopolysaccharides/pharmacology ; Animals ; Mice ; Electron Transport ; Mice, Inbred C57BL

Low production of mitochondrial reactive oxygen species after anoxia and reoxygenation in turtle hearts.

Authors: Bundgaard A; CECAD, University of Cologne, 50931 Cologne, Germany.; Department of Biology, Aarhus University, DK-8000 Aarhus, Denmark., Gruszczyk AV; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Williams C; Department of Biology, Aarhus University, DK-8000 Aarhus, Denmark., McIntyre A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Ruhr IM; Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, UK., James AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Galli GLJ; Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Fago A; Department of Biology, Aarhus University, DK-8000 Aarhus, Denmark.

Source: The Journal of experimental biology [J Exp Biol] 2023 May 01; Vol. 226 (9). Date of Electronic Publication: 2023 May 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 0243705 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9145 (Electronic) Linking ISSN: 00220949 NLM ISO Abbreviation: J Exp Biol Subsets: MEDLINE

MeSH Terms: Turtles*/metabolism, Reactive Oxygen Species/metabolism ; Superoxides/metabolism ; Hydrogen Peroxide/metabolism ; Hypoxia/metabolism ; Mitochondria, Heart/metabolism ; Succinic Acid/metabolism ; Succinates/metabolism ; Mammals/metabolism ; Animals

Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation.

Authors: Allen FM; MRC Mitochondrial Biology Unit, University of Cambridge, UK., Costa ASH; MRC Cancer Unit, University of Cambridge, UK., Gruszczyk AV; MRC Mitochondrial Biology Unit, University of Cambridge, UK., Bates GR; MRC Mitochondrial Biology Unit, University of Cambridge, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, UK., Nikitopoulou E; MRC Cancer Unit, University of Cambridge, UK., Viscomi C; Department of Biomedical Sciences, University of Padova, Italy., Frezza C; MRC Cancer Unit, University of Cambridge, UK., James AM; MRC Mitochondrial Biology Unit, University of Cambridge, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, UK.; Department of Medicine, University of Cambridge, UK.

Source: FEBS letters [FEBS Lett] 2023 Jan; Vol. 597 (2), pp. 246-261. Date of Electronic Publication: 2022 Oct 27.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

MeSH Terms: Mitochondria* , Heart*, Cytosol/metabolism ; Liver/metabolism ; Mitochondria, Liver/metabolism ; Mitochondria, Heart/metabolism ; Cell Fractionation/methods ; Mice ; Animals

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.

Authors: Tilokani L; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Russell FM; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK., Hamilton S; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Virga DM; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Segawa M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Paupe V; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Gruszczyk AV; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Protasoni M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Tabara LC; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Johnson M; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Anand H; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK., Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Hardie DG; Division of Cell Signalling & Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK., Polleux F; Department of Neuroscience, Columbia University, New York, NY 10032, USA., Prudent J; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Hills Road, CB2 0XY Cambridge, UK.

Source: Science advances [Sci Adv] 2022 Nov 11; Vol. 8 (45), pp. eabo7956. Date of Electronic Publication: 2022 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

MeSH Terms: AMP-Activated Protein Kinases*/metabolism , Mitochondrial Dynamics*, Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Membrane Proteins/metabolism ; Mammals/metabolism ; Animals ; Mice ; Phosphorylation

Mitochondrial metabolism and bioenergetic function in an anoxic isolated adult mouse cardiomyocyte model of in vivo cardiac ischemia-reperfusion injury.

Authors: Gruszczyk AV; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK; NIHR Biomedical Research Centre and NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge Biomedical Campus, Cambridge, UK., Casey AM; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., James AM; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Prag HA; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Burger N; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Bates GR; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Hall AR; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Allen FM; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Krieg T; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK., Saeb-Parsy K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK; NIHR Biomedical Research Centre and NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge Biomedical Campus, Cambridge, UK., Murphy MP; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk.

Source: Redox biology [Redox Biol] 2022 Aug; Vol. 54, pp. 102368. Date of Electronic Publication: 2022 Jun 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

MeSH Terms: Myocytes, Cardiac*/metabolism , Reperfusion Injury*/metabolism, Hypoxia/metabolism ; Ischemia/metabolism ; Lactates/metabolism ; Reactive Oxygen Species/metabolism ; Succinic Acid/metabolism ; Animals ; Disease Models, Animal ; Energy Metabolism ; Mice

Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.

Authors: Mills EL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Harmon C; Department of Immunology, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, USA., Jedrychowski MP; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Xiao H; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Gruszczyk AV; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK., Bradshaw GA; Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA., Tran N; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Garrity R; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Laznik-Bogoslavski D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Szpyt J; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Prendeville H; School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland., Lynch L; Department of Immunology, Harvard Medical School, Boston, MA, USA; Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, USA; School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland., Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Spiegelman BM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Chouchani ET; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address: edwardt_chouchani@dfci.harvard.edu.

Source: Cell metabolism [Cell Metab] 2022 Jan 04; Vol. 34 (1), pp. 140-157.e8. Date of Electronic Publication: 2021 Dec 02.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE

MeSH Terms: Adipose Tissue, Brown*/metabolism , Cysteine*/metabolism, Adipose Tissue/metabolism ; Inflammation/metabolism ; Thermogenesis/physiology ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism ; Animals ; Energy Metabolism ; Female ; Male ; Mice

DJ-1: A promising therapeutic candidate for ischemia-reperfusion injury.

Authors: De Lazzari F; Physiology, Genetics and Behaviour Unit, Department of Biology, University of Padova, 35131, Padova, Italy., Prag HA; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Gruszczyk AV; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Whitworth AJ; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0XY, UK., Bisaglia M; Physiology, Genetics and Behaviour Unit, Department of Biology, University of Padova, 35131, Padova, Italy. Electronic address: marco.bisaglia@unipd.it.

Source: Redox biology [Redox Biol] 2021 May; Vol. 41, pp. 101884. Date of Electronic Publication: 2021 Jan 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

MeSH Terms: Reperfusion Injury*, Animals ; Disease Models, Animal ; Ischemia ; Protein Deglycase DJ-1 ; Reactive Oxygen Species

Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart.

Authors: Park M; Department of Medicine, University of Cambridge, Cambridge, UK., Nishimura T; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Takeda Pharmaceutical Ltd, Tokyo, Japan., Baeza-Garza CD; WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK., Caldwell ST; WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK., Pun PBL; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Young T; Department of Medicine, University of Cambridge, Cambridge, UK., Sauchanka O; Department of Medicine, University of Cambridge, Cambridge, UK., Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Forkink M; Department of Medicine, University of Cambridge, Cambridge, UK., Gruszczyk AV; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Prime TA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Arndt S; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Naudi A; Department Of Experimental Medicine, University of Lleida, Lleida Institute for Biomedical Research, Lleida, Spain., Pamplona R; Department Of Experimental Medicine, University of Lleida, Lleida Institute for Biomedical Research, Lleida, Spain., Coughlan MT; Department of Diabetes, Monash University, Melbourne, Australia., Tate M; Department of Diabetes, Monash University, Melbourne, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia., Ritchie RH; Department of Diabetes, Monash University, Melbourne, Australia.; Baker Heart and Diabetes Institute, Melbourne, Australia., Caicci F; Department of Biology, University of Padova, Padua, Italy., Kaludercic N; Neuroscience Institute, National Research Council of Italy (CNR), Pisa, Italy., Di Lisa F; Department of Biomedical Sciences, University of Padova, Padua, Italy., Smith RAJ; Department of Chemistry, University of Otago, Otago, New Zealand., Hartley RC; WestCHEM School of Chemistry, University of Glasgow, Glasgow, UK., Murphy MP; Department of Medicine, University of Cambridge, Cambridge, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Krieg T; Department of Medicine, University of Cambridge, Cambridge, UK. tk382@medschl.cam.ac.uk.

Source: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2020 Dec; Vol. 34 (6), pp. 823-834. Date of Electronic Publication: 2020 Sep 26.

Publication Type: Journal Article

Journal Info: Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE

MeSH Terms: Benzamides/*pharmacology , Cardiovascular Agents/*pharmacology , Diabetic Cardiomyopathies/*prevention & control , Heart Failure/*prevention & control , Stroke Volume/*drug effects , Ventricular Dysfunction, Left/*prevention & control , Ventricular Function, Left/*drug effects, Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/physiopathology ; Glycation End Products, Advanced/metabolism ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/metabolism ; Ventricular Dysfunction, Left/metabolism ; Ventricular Dysfunction, Left/physiopathology ; Animals ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Mice, Mutant Strains

Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury.

Authors: Beach TE; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Pala L; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK., Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Huang MM; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK., Gruszczyk AV; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Martin JL; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK., Mahbubani K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK., Hamed MO; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK., Hosgood SA; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK., Nicholson ML; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK., James AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK., Hartley RC; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk., Saeb-Parsy K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address: ks10014@cam.ac.uk.

Source: Redox biology [Redox Biol] 2020 Sep; Vol. 36, pp. 101640. Date of Electronic Publication: 2020 Jul 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

MeSH Terms: Prodrugs*/pharmacology , Reperfusion Injury*/drug therapy, Succinate Dehydrogenase/metabolism ; Animals ; Esters ; Humans ; Malonates ; Mice ; Swine

Microtubule-dependent and independent roles of spastin in lipid droplet dispersion and biogenesis.

Authors: Tadepalle N; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Robers L; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Veronese M; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Zentis P; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Babatz F; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Brodesser S; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Gruszczyk AV; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Schauss A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Höning S; Institute for Biochemistry I, University of Cologne, Cologne, Germany., Rugarli EI; Institute for Genetics, University of Cologne, Cologne, Germany elena.rugarli@uni-koeln.de.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.

Source: Life science alliance [Life Sci Alliance] 2020 Apr 22; Vol. 3 (6). Date of Electronic Publication: 2020 Apr 22 (Print Publication: 2020).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE

MeSH Terms: Endoplasmic Reticulum/*metabolism , Lipid Droplets/*metabolism , Microtubules/*metabolism , Signal Transduction/*genetics , Spastic Paraplegia, Hereditary/*metabolism , Spastin/*deficiency, Fibroblasts/metabolism ; Motor Neurons/metabolism ; Spastic Paraplegia, Hereditary/genetics ; Spastin/genetics ; Triglycerides/metabolism ; Animals ; Cell Line, Tumor ; Gene Knockout Techniques ; HEK293 Cells ; Humans ; Isoenzymes ; Mice ; Mutation ; Transfection

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.

Authors: Martin JL; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK., Costa ASH; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK., Gruszczyk AV; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Beach TE; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK., Allen FM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Hinchy EC; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Mahbubani K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK., Hamed M; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK., Tronci L; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK., Nikitopoulou E; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK., James AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Krieg T; Department of Medicine, University of Cambridge, Cambridge, UK., Robinson AJ; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Huang MM; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK.; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Caldwell ST; School of Chemistry, University of Glasgow, Glasgow, UK., Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Pala L; School of Chemistry, University of Glasgow, Glasgow, UK., Hartley RC; School of Chemistry, University of Glasgow, Glasgow, UK., Frezza C; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, UK., Saeb-Parsy K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. mpm@mrc-mbu.cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. mpm@mrc-mbu.cam.ac.uk.

Source: Nature metabolism [Nat Metab] 2019 Sep 30; Vol. 1, pp. 966-974.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab

MeSH Terms: Organ Transplantation*, Reperfusion Injury/*metabolism , Succinic Acid/*metabolism, Animals ; Humans ; Mice ; Swine

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.

Authors: Martin JL; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK.; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Gruszczyk AV; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK.; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Beach TE; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK., Murphy MP; MRC Mitochondrial Biology Unit, Biomedical Campus, University of Cambridge, Cambridge, CB2 0XY, UK., Saeb-Parsy K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 2QQ, UK. ks10014@cam.ac.uk.

Source: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2019 Jul; Vol. 34 (7), pp. 1167-1174. Date of Electronic Publication: 2018 Jun 02.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE

MeSH Terms: Acute Kidney Injury/*prevention & control , Mitochondria/*metabolism , Reactive Oxygen Species/*metabolism , Reperfusion Injury/*metabolism, Acute Kidney Injury/blood ; Acute Kidney Injury/etiology ; Antioxidants/therapeutic use ; Biomarkers/blood ; DNA, Mitochondrial/blood ; Kidney Tubules/pathology ; Reperfusion Injury/complications ; Reperfusion Injury/immunology ; Reperfusion Injury/therapy ; Apoptosis ; Humans ; Mitophagy ; Necrosis ; Oxidative Stress

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.

Authors: Antonucci S; Department of Biomedical Sciences, University of Padova, 35131, Padova, Italy., Mulvey JF; Department of Medicine, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Burger N; Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Di Sante M; Department of Biomedical Sciences, University of Padova, 35131, Padova, Italy., Hall AR; Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Hinchy EC; Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Caldwell ST; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK., Gruszczyk AV; Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Deshwal S; Department of Biomedical Sciences, University of Padova, 35131, Padova, Italy., Hartley RC; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK., Kaludercic N; Neuroscience Institute, National Research Council of Italy (CNR), 35131, Padova, Italy., Murphy MP; Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Di Lisa F; Department of Biomedical Sciences, University of Padova, 35131, Padova, Italy; Neuroscience Institute, National Research Council of Italy (CNR), 35131, Padova, Italy. Electronic address: dilisa@bio.unipd.it., Krieg T; Department of Medicine, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK. Electronic address: tk382@medschl.cam.ac.uk.

Source: Free radical biology & medicine [Free Radic Biol Med] 2019 Apr; Vol. 134, pp. 678-687. Date of Electronic Publication: 2019 Feb 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE

MeSH Terms: Disease Models, Animal* , Hormesis*, Mitochondria, Heart/*metabolism , Myocardial Reperfusion Injury/*prevention & control , Myocytes, Cardiac/*cytology , Paraquat/*pharmacology , Superoxides/*metabolism, Herbicides/pharmacology ; Mitochondria, Heart/drug effects ; Mitochondria, Heart/pathology ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Animals ; Animals, Newborn ; Apoptosis ; Male ; Mice ; Mice, Inbred C57BL ; Rats ; Rats, Wistar