Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension

Συγγραφείς: Leuillier, Matthieu, Chelgham, Mustapha, Messaoudi, Hind, Tu, Ly, Ménoret, Severine, Thuillet, Raphaël, Groussard, Déborah, Lillich, Felix, Ottaviani, Mina, Nicol, Lionel, Mulder, Paul, Humbert, Marc, Richard, Vincent, Anegon, Ignacio, Morisseau, Christophe, Proschak, Ewgenij, Guignabert, Christophe, Bellien, Jérémy

Συνεισφορές: KERANDEL-DION, Céline

Πηγή: Compr Physiol

Θεματικοί όροι: Epoxide Hydrolases, Male, phosphatase activity, Hypertension, Pulmonary, Myocytes, Smooth Muscle, soluble epoxide hydrolase, Pulmonary Artery, Rats, SIRT3, [SDV] Life Sciences [q-bio], Rats, Sprague-Dawley, Sirtuin 3, pulmonary hypertension, Animals, Humans, Sirtuins, Cells, Cultured, Research Article

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41652841
https://pmc.ncbi.nlm.nih.gov/articles/PMC12881838/
https://pubmed.ncbi.nlm.nih.gov/41652841/
https://doi.org/10.1002/cph4.70108
https://inserm.hal.science/inserm-05577851v1
https://inserm.hal.science/inserm-05577851v1/document
https://doi.org/10.1002/cph4.70108

Inhibition of Soluble Epoxide Hydrolase Does Not Promote or Aggravate Pulmonary Hypertension in Rats

Συγγραφείς: Leuillier, Matthieu, Platel, Valentin, Tu, Ly, Feugray, Guillaume, Thuillet, Raphaël, Groussard, Déborah, Messaoudi, Hind, Ottaviani, Mina, Chelgham, Mustapha, Nicol, Lionel, Mulder, Paul, Humbert, Marc, Richard, Vincent, Morisseau, Christophe, Brunel, Valéry, Duflot, Thomas, Guignabert, Christophe, Bellien, Jérémy

Πηγή: Cells. 12(4)

Θεματικοί όροι: Biomedical and Clinical Sciences, Clinical Sciences, Lung, Cardiovascular, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Rats, Humans, Animals, Hypertension, Pulmonary, Epoxide Hydrolases, Heart, Cells, Cultured, soluble epoxide hydrolase, epoxyeicosatrienoic acids, pulmonary arterial hypertension, right ventricular dysfunction, Biological sciences, Biomedical and clinical sciences

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/23d008kf
https://escholarship.org/content/qt23d008kf/qt23d008kf.pdf

CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury

Συγγραφείς: Leuillier, Matthieu, Duflot, Thomas, Ménoret, Séverine, Messaoudi, Hind, Djerada, Zoubir, Groussard, Déborah, Denis, Raphaël GP, Chevalier, Laurence, Karoui, Ahmed, Panthu, Baptiste, Thiébaut, Pierre-Alain, Schmitz-Afonso, Isabelle, Nobis, Séverine, Campart, Cynthia, Henry, Tiphaine, Sautreuil, Camille, Luquet, Serge H, Beseme, Olivia, Féliu, Catherine, Peyret, Hélène, Nicol, Lionel, Henry, Jean-Paul, Renet, Sylvanie, Mulder, Paul, Wan, Debin, Tesson, Laurent, Heslan, Jean-Marie, Duché, Angéline, Jacques, Sébastien, Ziegler, Frédéric, Brunel, Valéry, Rautureau, Gilles JP, Monteil, Christelle, do Rego, Jean-Luc, do Rego, Jean-Claude, Afonso, Carlos, Hammock, Bruce, Madec, Anne-Marie, Pinet, Florence, Richard, Vincent, Anegon, Ignacio, Guignabert, Christophe, Morisseau, Christophe, Bellien, Jérémy

Πηγή: Journal of Advanced Research. 43

Θεματικοί όροι: 3101 Biochemistry and Cell Biology (for-2020), 32 Biomedical and Clinical Sciences (for-2020), 31 Biological Sciences (for-2020), Nutrition (rcdc), Cardiovascular (rcdc), Genetics (rcdc), Obesity (rcdc), 2.1 Biological and endogenous factors (hrcs-rac), Cardiovascular (hrcs-hc), Metabolic and endocrine (hrcs-hc), Animals (mesh), Female (mesh), Male (mesh), Rats (mesh), CRISPR-Cas Systems (mesh), Epoxide Hydrolases (mesh), Heart Diseases (mesh), Heart Injuries (mesh), Insulin Resistance (mesh), Lysophospholipids (mesh), Obesity (mesh), Phosphoric Monoester Hydrolases (mesh), Reperfusion Injury (mesh), Soluble epoxide hydrolase, Lipid phosphatase, CRISPR-Cas9, Thermogenesis, Obesity, Cardiac ischemic injury, Animals (mesh), Rats (mesh), Heart Diseases (mesh), Reperfusion Injury (mesh), Insulin Resistance (mesh), Obesity (mesh), Heart Injuries (mesh), Epoxide Hydrolases (mesh), Phosphoric Monoester Hydrolases (mesh), Lysophospholipids (mesh), Female (mesh), Male (mesh), CRISPR-Cas Systems (mesh), CRISPR-Cas9, Cardiac ischemic injury, Lipid phosphatase, Obesity, Soluble epoxide hydrolase, Thermogenesis, Animals (mesh), Female (mesh), Male (mesh), Rats (mesh), CRISPR-Cas Systems (mesh), Epoxide Hydrolases (mesh), Heart Diseases (mesh), Heart Injuries (mesh), Insulin Resistance (mesh), Lysophospholipids (mesh), Obesity (mesh), Phosphoric Monoester Hydrolases (mesh), Reperfusion Injury (mesh)

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://escholarship.org/uc/item/1qj4r9ns
https://escholarship.org/content/qt1qj4r9ns/qt1qj4r9ns.pdf

Chronic endothelial dopamine receptor stimulation improves endothelial function and hemodynamics in autosomal dominant polycystic kidney disease

Συγγραφείς: Dumont, Audrey ^{1, 2, 3}, Hamzaoui, Mouad ⁴, Groussard, Déborah ¹, Iacob, Michèle ², Bertrand, Dominique ⁴, Remy-Jouet, Isabelle ¹, Hanoy, Mélanie ⁴, Le Roy, Frank ⁴, Chevalier, Laurence ⁵, Enzensperger, Christoph ⁶, Arndt, Hans-Dieter ⁶, Renet, Sylvanie ¹, Dumesnil, Anaïs ¹, Lévêque, Emilie ⁷, Duflot, Thomas ^{1, 2}, Brunel, Valéry ⁸, Michel-Després, Aurore ⁹, Audrézet, Marie-Pierre ⁹, Richard, Vincent ^{2, 3}, Joannidès, Robinson ^{1, 2}, Guerrot, Dominique ^{1, 3, 4}, Bellien, Jérémy ^{1, 2, 3, ∗}

Πηγή: In Kidney International December 2024 106(6):1158-1169

Clostridioides difficile binary toxin CDT induces biofilm-like persisting microcolonies

Συγγραφείς: Meza-Torres, Jazmin, Tinevez, Jean-Yves, Crouzols, Aline, Mary, Héloïse, Kim, Minhee, Hunault, Lise, Chamorro-Rodriguez, Susan, Lejal, Emilie, Altamirano-Silva, Pamela, Groussard, Déborah, Gobaa, Samy, Peltier, Johann, Chassaing, Benoit, Dupuy, Bruno

Συνεισφορές: peltier, johann

Πηγή: Gut Microbes
Gut Microbes, Vol 17, Iss 1 (2025)

Θεματικοί όροι: antibiotic resistance, Colon, Bacterial Toxins, mucin-associated microcolonies, RC799-869, Clostridioides difficile Infection (CDI), biofilm, Mice, gut persistence, Bacterial Proteins, Vancomycin, Animals, Humans, Cecum, CDT binary toxin, relapse, ADP Ribose Transferases, Clostridioides difficile, Diseases of the digestive system. Gastroenterology, Anti-Bacterial Agents, [SDV] Life Sciences [q-bio], Mice, Inbred C57BL, Disease Models, Animal, Biofilms, Clostridium Infections, Female, Research Paper

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39719371
https://pmc.ncbi.nlm.nih.gov/articles/PMC12931720/
https://pubmed.ncbi.nlm.nih.gov/39719371/
https://doi.org/10.1080/19490976.2024.2444411
https://doaj.org/article/8bc59a2535474896bdd08e505fa58218
https://hal.science/hal-04862908v1
https://doi.org/10.1080/19490976.2024.2444411
https://hal.science/hal-04862908v1/document

Enhanced perceptual task performance without deprivation in mice using medial forebrain bundle stimulation

Συγγραφείς: Verdier, Antonin ¹, Dominique, Noémi ², Groussard, Déborah ², Aldanondo, Anna ¹, Bathellier, Brice ^{1, 3}, Bagur, Sophie ^{1, 3, 4, ∗}

Πηγή: In Cell Reports Methods 19 December 2022 2(12)

Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI

Συγγραφείς: Rondeaux, Julie^Aff1, Groussard, Déborah^Aff1, Renet, Sylvanie^Aff1, Tardif, Virginie^Aff1, Dumesnil, Anaïs^Aff1, Chu, Alphonse^Aff2, Di Maria, Léa^Aff1, Lemarcis, Théo^Aff1, Valet, Manon^Aff1, Henry, Jean-Paul^Aff1, Badji, Zina^Aff3, Vézier, Claire^Aff3, Béziau-Gasnier, Delphine^Aff3, Neele, Annette E.^Aff4, de Winther, Menno P. J.^Aff4, Guerrot, Dominique^Aff5, Brand, Marjorie^Aff2, Richard, Vincent^Aff6, Durand, Eric^Aff7, Brakenhielm, Ebba^Aff1, Fraineau, Sylvain^{Aff1, IDs41467023401860_cor21}

Πηγή: Nature Communications. 14(1)

Endothelium-Specific Deficiency of Polycystin-1 Promotes Hypertension and Cardiovascular Disorders

Συγγραφείς: Hamzaoui, Mouad, Groussard, Deborah, Nezam, Dorian, Djerada, Zoubir, Lamy, Gaspard, Tardif, Virginie, Dumesnil, Anais, Renet, Sylvanie, Brunel, Valery, Peters, Dorien J.M., Chevalier, Laurence, Hanoy, Mélanie, Mulder, Paul, Richard, Vincent, Bellien, Jeremy, Guerrot, Dominique

Πηγή: Hypertension ; volume 79, issue 11, page 2542-2551 ; ISSN 0194-911X 1524-4563

Διαθεσιμότητα: https://doi.org/10.1161/hypertensionaha.122.19057
https://www.ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.122.19057

ENDOTHELIUM-SPECIFIC DEFICIENCY OF POLYCYSTIN-1 PROMOTES HYPERTENSION AND CARDIOVASCULAR DISORDERS

Συγγραφείς: Guerrot, Dominique, Hamzaoui, Mouad, Groussard, Deborah, Nezam, Dorian, Mulder, Paul, Richard, Vincent, Bellien, Jeremy

Πηγή: Journal of Hypertension ; volume 40, issue Suppl 1, page e38 ; ISSN 0263-6352 1473-5598

Διαθεσιμότητα: https://doi.org/10.1097/01.hjh.0000835596.33668.f9
https://journals.lww.com/10.1097/01.hjh.0000835596.33668.f9

Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?

Συγγραφείς: Duflot, Thomas, Tu, Ly, Leuillier, Matthieu, Messaoudi, Hind, Groussard, Déborah, Feugray, Guillaume, Azhar, Saïda, Thuillet, Raphaël, Bauer, Fabrice, Humbert, Marc, Richard, Vincent, Guignabert, Christophe, Bellien, Jérémy

Συνεισφορές: Endothélium, valvulopathies et insuffisance cardiaque (EnVI), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Rouen, Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Université Paris-Saclay, Hôpital Marie-Lannelongue, Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, TargEDys Rouen, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), ANR-16-CE17-0012,SAPHIR,Impact de la modulation des activités enzymatiques de l'époxyde hydrolase soluble sur l'hypertension pulmonaire et la dysfonction ventriculaire droite lors de l'insuffisance cardiaque expérimentale et humaine(2016)

Πηγή: ISSN: 2218-1989 ; Metabolites ; https://hal.science/hal-04532610 ; Metabolites, 2021, 11 (11), pp.784. ⟨10.3390/metabo11110784⟩.

Θεματικοί όροι: [SDV]Life Sciences [q-bio]

Διαθεσιμότητα: https://hal.science/hal-04532610
https://hal.science/hal-04532610v1/document
https://hal.science/hal-04532610v1/file/metabolites-11-00784.pdf
https://doi.org/10.3390/metabo11110784

Enhanced perceptual task performance without deprivation in mice using medial forebrain bundle stimulation

Συγγραφείς: Verdier, Antonin, primary, Dominique, Noémi, additional, Groussard, Déborah, additional, Aldanondo, Anna, additional, Bathellier, Brice, additional, Bagur, Sophie, additional

Πηγή: 2022/03/30

Σύνδεσμος πρόσβασης: https://hal.science/hal-04455170/document

Lysophospholipids, Lysophosphatidic Acids and Monoacylglycerols: New Therapeutic Targets in Cardiovascular Diseases?

Συγγραφείς: Duflot, Thomas, primary, Tu, Ly, additional, Leuillier, Matthieu, additional, Messaoudi, Hind, additional, Groussard, Déborah, additional, Azhar, Saïda, additional, Thuillet, Raphaël, additional, Humbert, Marc, additional, Richard, Vincent, additional, Guignabert, Christophe, additional, Bellien, Jérémy, additional

Πηγή: 2021/09/03

Σύνδεσμος πρόσβασης: https://www.preprints.org/manuscript/202109.0071/v1/download

Anomalies de l'adaptation cardiovasculaire de la polykystose rénale autosomique dominante : analyse du role de l'endothélium et impact thérapeutique d'un agoniste dopaminergique. ; Αnοmalies οn cardiοvascular adaptation οn autοsοmic renal pοlykystosis : analysis of the role οf thе endοthelium аnd thе therapeutic impact οf a dοpaminergic agοnist.

Συγγραφείς: Groussard, Deborah

Συνεισφορές: Normandie, Guerrot, Dominique

Θεματικοί όροι: Polykystose rénale autosomique dominante, Polycystine 1, Fistule artérioveineuse, Endothélium, Autosomal polycystic kidney disease, Polycystin 1, Arterio-venous fistula, Endothelium

Relation: http://www.theses.fr/2021NORMR074

Διαθεσιμότητα: http://www.theses.fr/2021NORMR074