Targeting of the PI3 K/AKT/GSK3β Pathway in Parkinson's Disease: A Therapeutic Blueprint.

Authors: AlRuwaili R; Department of Internal Medicine, College of Medicine, Northern Border University, Arar, Saudi Arabia., Al-Kuraishy HM; Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq., Al-Gareeb AI; Jabir Ibn Hayyan Medical University, Najaf, Iraq., Albuhadily AK; Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq., Alexiou A; Department of Research & Development, Funogen, Attiki, Athens, 11741, Greece.; University Centre for Research & Development, Chandigarh University, Chandigarh-Ludhiana Highway, Mohali, Punjab, India., Papadakis M; University Hospital Witten-Herdecke, University of Witten-Herdecke, Heusnerstrasse 40, Wuppertal, 42283, Germany. drmariospapadakis@gmail.com., Fetoh MEA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, 11829, Egypt. mohamed-ezzat@eru.edu.eg., Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, 22511, Egypt. gaberbatiha@gmail.com.

Source: Molecular neurobiology [Mol Neurobiol] 2025 Nov; Vol. 62 (11), pp. 15108-15131. Date of Electronic Publication: 2025 Jun 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

MeSH Terms: Parkinson Disease*/drug therapy , Parkinson Disease*/metabolism , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Proto-Oncogene Proteins c-akt*/metabolism , Signal Transduction*/drug effects , Signal Transduction*/physiology , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinase*/metabolism , Molecular Targeted Therapy*, Humans ; Animals ; Oxidative Stress ; Dopaminergic Neurons/metabolism

Screening Natural Phenolic Compounds for Blood-Brain Barrier Permeability, Alongside GSK-3β, CK-1δ, and AChE Inhibition, for the Treatment of Alzheimer's Disease.

Authors: Gürbüz P; Department of Pharmacognosy, Faculty of Pharmacy, Erciyes University, Kayseri, Türkiye., Doğan ŞD; Department of Basic Sciences, Faculty of Pharmacy, Erciyes University, Kayseri, Türkiye., Gündüz MG; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Türkiye., Martínez-González L; Centro de Investigaciones Biologicas, CSIC, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain., Pérez C; Medicinal Chemistry Institute-CSIC, Madrid, Spain., Martinez A; Centro de Investigaciones Biologicas, CSIC, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.

Source: Drug development research [Drug Dev Res] 2025 Dec; Vol. 86 (8), pp. e70193.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8204468 Publication Model: Print Cited Medium: Internet ISSN: 1098-2299 (Electronic) Linking ISSN: 02724391 NLM ISO Abbreviation: Drug Dev Res Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/drug therapy , Blood-Brain Barrier*/metabolism , Blood-Brain Barrier*/drug effects , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemistry , Cholinesterase Inhibitors*/pharmacokinetics , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/pharmacokinetics , Neuroprotective Agents*/chemistry , Phenols*/pharmacology , Phenols*/chemistry, Humans ; Molecular Docking Simulation ; Acetylcholinesterase/metabolism ; Permeability

Circ_GLS/miR-410-3p/GSK3beta/beta-catenin axis modulates malignant phenotypes of non-small cell lung cancer cells via regulation of cell cycle, apoptosis, ferroptosis, and EMT.

Authors: Wang K; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China., Wu Z; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China., Lu T; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China., Wang J; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China., Gao M; Department of Health Management, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China., Song Y; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China. Electronic address: songyongxiang@zmu.edu.cn., Chen C; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China. Electronic address: chencheng@zmu.edu.cn., Ke X; Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China; The Public Experimental Center of Medicine, Affiliated Hospital of Zunyi Medical University, 149 Dalian Road, Zunyi, 563000, Guizhou, China. Electronic address: kexixian@zmu.edu.cn.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2025 Dec; Vol. 334 (Pt 1), pp. 148830. Date of Electronic Publication: 2025 Nov 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

MeSH Terms: Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Glycogen Synthase Kinase 3 beta*/metabolism , Epithelial-Mesenchymal Transition*/genetics , RNA, Circular*/genetics , RNA, Circular*/metabolism , beta Catenin*/metabolism , beta Catenin*/genetics , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Lung Neoplasms*/metabolism , Ferroptosis*/genetics, Humans ; Apoptosis/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Cell Cycle/genetics ; Animals ; Cell Proliferation/genetics ; Mice ; Cell Movement/genetics ; Phenotype

Design, synthesis, and biological evaluation of kenpaullone derivatives as potential dual inhibitors of cholinesterases and glycogen synthase kinase-3β.

Authors: Raghuvanshi R; Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research, Ghaziabad 201002, India., Wakudkar SC; Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India., Manda S; Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research, Ghaziabad 201002, India., Bharate SB; Natural Products & Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research, Ghaziabad 201002, India; Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: sbharate.iict@csir.res.in.

Source: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109232. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Cholinesterase Inhibitors*/chemical synthesis , Cholinesterase Inhibitors*/pharmacology , Cholinesterase Inhibitors*/chemistry , Drug Design* , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Glycogen Synthase Kinase 3*/metabolism, Humans ; Structure-Activity Relationship ; Molecular Docking Simulation ; Acetylcholinesterase/metabolism ; Molecular Structure ; Dose-Response Relationship, Drug ; Butyrylcholinesterase/metabolism ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/drug therapy

Identification of glycogen synthase kinase 3alpha/beta as a host factor required for HBV transcription using high-throughput screening.

Authors: Nishitsuji H; Department of Virology, Fujita Health University School of Medicine, Toyoake, Japan.; Center for Infectious Disease Research, Research Promotion Headquarters, Fujita Health University, Toyoake, Japan., Naito Y; Department of Virology, Fujita Health University School of Medicine, Toyoake, Japan., Murakami Y; Department of Virology, Fujita Health University School of Medicine, Toyoake, Japan., Sugiyama M; Department of Viral Pathogenesis and Controls, National Center for Global Health and Medicine, Ichikawa, Japan., Mizokami M; Genome Medical Science Project, National Center for Global Health and Medicine, Ichikawa, Japan., Shoji I; Division of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan., Murata T; Department of Virology, Fujita Health University School of Medicine, Toyoake, Japan.; Center for Infectious Disease Research, Research Promotion Headquarters, Fujita Health University, Toyoake, Japan., Shimotohno K; Genome Medical Science Project, National Center for Global Health and Medicine, Ichikawa, Japan.; Laboratory of Microbial Carcinogenesis, Institute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan.

Source: Hepatology (Baltimore, Md.) [Hepatology] 2025 Dec 01; Vol. 82 (6), pp. 1551-1564. Date of Electronic Publication: 2025 Jan 23.

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

MeSH Terms: Hepatitis B virus*/physiology , Hepatitis B virus*/genetics , Hepatitis B virus*/drug effects , Glycogen Synthase Kinase 3*/antagonists & inhibitors , Glycogen Synthase Kinase 3*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Hepatitis B*/drug therapy , Hepatitis B*/virology, Humans ; Hepatocytes/virology ; High-Throughput Screening Assays ; Virus Replication/drug effects ; Antiviral Agents/pharmacology ; Hep G2 Cells ; Symporters/metabolism ; Transcription, Genetic

Suppression of tumor growth by GMI, an edible fungal immunomodulatory protein, is associated with targeting GSK3β‑mediated proteasomal degradation of PD‑L1.

Authors: Hua WJ; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Huang LC; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Lin ZH; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Ciou YR; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Lin KF; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Liao LL; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Hsu WH; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C., Lin TY; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan, R.O.C.

Source: International journal of molecular medicine [Int J Mol Med] 2025 Dec; Vol. 56 (6). Date of Electronic Publication: 2025 Oct 10.

Publication Type: Journal Article

Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE

MeSH Terms: B7-H1 Antigen*/metabolism , B7-H1 Antigen*/genetics , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Proteasome Endopeptidase Complex*/metabolism , Fungal Proteins*/pharmacology , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Ganoderma*/chemistry, Animals ; Humans ; Mice ; Cell Line, Tumor ; Proteolysis/drug effects ; Mice, Inbred BALB C ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Signal Transduction/drug effects

Identification of a novel pyrrolo[2,3- b ]pyridine compound as a potent glycogen synthase kinase 3β inhibitor for treating Alzheimer's disease.

Authors: Xun QQ; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.; School of Clinical Medicine, Jining Medical University, Jining, Shandong, China., Zhang J; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Feng L; Department of Gastrointestinal Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Ma YY; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Li Y; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Shi XL; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.

Source: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2025 Dec; Vol. 40 (1), pp. 2466846. Date of Electronic Publication: 2025 Feb 20.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Pyridines*/pharmacology , Pyridines*/chemistry , Pyridines*/chemical synthesis , Pyrroles*/pharmacology , Pyrroles*/chemistry , Pyrroles*/chemical synthesis , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis, Humans ; Animals ; Structure-Activity Relationship ; Dose-Response Relationship, Drug ; Molecular Structure ; Zebrafish

A novel covalent inhibitor alleviates type 2 diabetes mellitus by restraining GSK-3β.

Authors: Zhang S; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Zhao F; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Pan C; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Wang Y; College of Stomatolgy, Guizhou Medical University, Guiyang 550004, China., Yang Z; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Yang J; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Meng Y; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Lv S; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Huang J; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China., Dong L; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China. Electronic address: dongli@gmc.edu.cn., Li L; Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China. Electronic address: shadow-ne@126.com., Dong Y; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine & School of Pharmacy, Guizhou Medical University, Guian New District 561113, China. Electronic address: dongyongxi@gmc.edu.cn.

Source: Biochemical pharmacology [Biochem Pharmacol] 2025 Dec; Vol. 242 (Pt 2), pp. 117205. Date of Electronic Publication: 2025 Aug 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

MeSH Terms: Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Diabetes Mellitus, Type 2*/enzymology , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/chemistry , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/therapeutic use , Hypoglycemic Agents*/chemistry , Thiadiazoles*/pharmacology , Thiadiazoles*/therapeutic use , Thiadiazoles*/chemistry, Animals ; Humans ; Mice ; Male ; Mice, Inbred C57BL ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Gastrointestinal Microbiome/drug effects

Neuronal GSK3β Protects Against Amyloid Pathology by Regulating APP Degradation.

Authors: Zhang Y; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, China., Zhang Y; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, China., Ge C; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, China., Liu Y; Suqian Scientific Research Institute of Nanjing University Medical School, Nanjing University, Nanjing, China.; Department of Neurology, Meishan Hospital of Nanjing, Nanjing, China., Wang Z; Suqian Scientific Research Institute of Nanjing University Medical School, Nanjing University, Nanjing, China.; Department of Neurology, Meishan Hospital of Nanjing, Nanjing, China., Chen G; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, China.; Suqian Scientific Research Institute of Nanjing University Medical School, Nanjing University, Nanjing, China.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 30; Vol. 39 (22), pp. e71267.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Amyloid beta-Protein Precursor*/metabolism , Amyloid beta-Protein Precursor*/genetics , Neurons*/metabolism , Neurons*/pathology , Alzheimer Disease*/metabolism , Alzheimer Disease*/pathology , Alzheimer Disease*/genetics , Amyloid beta-Peptides*/metabolism, Animals ; Mice ; Mice, Transgenic ; Mice, Knockout ; Proteolysis

Fucoxanthin suppresses amyloid-β and pyroglutamate-3-Aβ accumulation by modulating the PI3K/Akt/GSK-3β signaling pathway.

Authors: Lee N; Department of Health Sciences, The Graduate School of Dong-A University, 37 Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea., Youn K; Department of Food Science and Nutrition, Dong-A University, 37 Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea. mjun@dau.ac.kr.; Center for Food & Bio Innovation, Dong-A University, 37 Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea., Kwon H; Department of Health Sciences, The Graduate School of Dong-A University, 37 Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea., Lee J; Department of Cosmetics, College of K-Bio Health, Daegu Haany University, 1 Hanuidae-ro, Gyeongsan-si, Gyeongsangbuk-do 38610, Republic of Korea., Lee E; Department of Chemical Engineering, College of Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongsangbuk-do 38541, Republic of Korea., Jung JW; Department of Cosmetics, College of K-Bio Health, Daegu Haany University, 1 Hanuidae-ro, Gyeongsan-si, Gyeongsangbuk-do 38610, Republic of Korea., Moon M; Department of Biochemistry, College of Medicine, Konyang University, 158 Gwanjeodong-Ro, Seo-Gu, Daejeon 35365, Republic of Korea., Lee DS; School of Life Sciences & Biotechnology, College of Natural Sciences, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea., Kim DH; Department of Pharmacology and Department of Advanced Translational Medicine, School of Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea., Ho CT; Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA., Jun M; Department of Health Sciences, The Graduate School of Dong-A University, 37 Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea.; Department of Food Science and Nutrition, Dong-A University, 37 Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea. mjun@dau.ac.kr.; Center for Food & Bio Innovation, Dong-A University, 37 Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea.

Source: Food & function [Food Funct] 2025 Nov 24; Vol. 16 (23), pp. 9102-9117. Date of Electronic Publication: 2025 Nov 24.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE

MeSH Terms: Amyloid beta-Peptides*/metabolism , Amyloid beta-Peptides*/chemistry , Xanthophylls*/pharmacology , Xanthophylls*/administration & dosage , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinases*/genetics , Proto-Oncogene Proteins c-akt*/metabolism , Proto-Oncogene Proteins c-akt*/genetics , Alzheimer Disease*/metabolism , Alzheimer Disease*/drug therapy , Alzheimer Disease*/genetics , Pyrrolidonecarboxylic Acid*/metabolism, Animals ; Mice ; Signal Transduction/drug effects ; Male ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid Precursor Protein Secretases/genetics ; Humans ; Mice, Inbred C57BL ; ADAM10 Protein/metabolism ; ADAM10 Protein/genetics ; Aspartic Acid Endopeptidases/metabolism ; Aspartic Acid Endopeptidases/genetics

GSK-3β Regulates Tumor Stemness and Immune-Related Pathways in Triple-Negative Breast Cancer: A Bioinformatics and Experimental Validation Study.

Authors: Zhou L; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Wang X; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Zhu H; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Chen Y; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Bai L; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Hu C; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Wang Y; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Qi M; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China., Yin L; Abdominal Surgery Difficult Diagnosis and Treatment Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China., Sun J; Department of Thyroid and Breast Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.

Source: The breast journal [Breast J] 2025 Nov 20; Vol. 2025, pp. 5943807. Date of Electronic Publication: 2025 Nov 20 (Print Publication: 2025).

Publication Type: Journal Article; Validation Study

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 9505539 Publication Model: eCollection Cited Medium: Internet ISSN: 1524-4741 (Electronic) Linking ISSN: 1075122X NLM ISO Abbreviation: Breast J Subsets: MEDLINE

MeSH Terms: Triple Negative Breast Neoplasms*/genetics , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/mortality , Triple Negative Breast Neoplasms*/metabolism , Neoplastic Stem Cells*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Glycogen Synthase Kinase 3 beta*/metabolism, Humans ; Female ; Computational Biology ; Gene Expression Regulation, Neoplastic ; Epithelial-Mesenchymal Transition/genetics ; Proteomics ; Prognosis ; Middle Aged ; Biomarkers, Tumor/genetics

GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1.

Authors: Allam HS; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Acklin-Wehnert S; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA., Sadhukhan R; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Patra M; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Xia F; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Source: The Journal of clinical investigation [J Clin Invest] 2025 Nov 17; Vol. 135 (22). Date of Electronic Publication: 2025 Nov 17 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

MeSH Terms: Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , BRCA1 Protein*/metabolism , BRCA1 Protein*/genetics , Poly (ADP-Ribose) Polymerase-1*/antagonists & inhibitors , Poly (ADP-Ribose) Polymerase-1*/metabolism , Poly (ADP-Ribose) Polymerase-1*/genetics , DNA End-Joining Repair* , Poly(ADP-ribose) Polymerase Inhibitors*/pharmacology , DNA Repair*, Humans ; Tumor Suppressor p53-Binding Protein 1/metabolism ; Tumor Suppressor p53-Binding Protein 1/genetics ; Animals ; Mice ; Phosphorylation ; Cell Line, Tumor ; DNA Breaks, Double-Stranded ; Female ; Carrier Proteins/metabolism ; Carrier Proteins/genetics ; Telomere-Binding Proteins/metabolism ; Telomere-Binding Proteins/genetics ; Rad51 Recombinase/metabolism ; Rad51 Recombinase/genetics ; Nuclear Proteins/metabolism ; Nuclear Proteins/genetics ; Endodeoxyribonucleases

ESCRT-III Subunit CHMP4C Regulates Angiogenesis by Targeting Endocytic Trafficking of GSK3β.

Authors: Liu W; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Ding S; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China., Zhang Z; Reproductive Medicine Centre, Zhongshan Hospital, Fudan University, Shanghai, China., Zhou N; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Weng H; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Xie H; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Tian F; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Liu A; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Wei X; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Xu N; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China., Yang X; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China., Shu X; Department of Echocardiography, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China.; Shanghai Institute of Medical Imaging, Fudan University, Shanghai, China.

Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2025 Nov 15; Vol. 39 (21), pp. e71174.

Publication Type: Journal Article

Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

MeSH Terms: Endosomal Sorting Complexes Required for Transport*/metabolism , Endosomal Sorting Complexes Required for Transport*/genetics , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , Ischemia*/metabolism , Ischemia*/pathology , Neovascularization, Physiologic*/physiology , Endocytosis*/physiology, Animals ; Mice ; Mice, Inbred C57BL ; Humans ; Cell Proliferation ; Mice, Knockout ; Male ; Wnt Signaling Pathway ; Endothelial Cells/metabolism ; Human Umbilical Vein Endothelial Cells/metabolism ; Hindlimb/blood supply ; Protein Transport ; Angiogenesis

Lithium restores inhibitory function and neuronal excitability through GSK-3β inhibition in a bipolar disorder-associated Ank3 variant mouse model.

Authors: Caballero-Florán RN; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109-5632, USA., Dean KP; Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI, 48109-5632, USA., Nelson AD; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, 94143, USA., Min L; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109-5632, USA., Jenkins PM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109-5632, USA; Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, 48109-5632, USA. Electronic address: pjenkins@umich.edu.

Source: Neuropharmacology [Neuropharmacology] 2025 Nov 15; Vol. 279, pp. 110649. Date of Electronic Publication: 2025 Aug 22.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

MeSH Terms: Bipolar Disorder*/genetics , Bipolar Disorder*/drug therapy , Bipolar Disorder*/physiopathology , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Ankyrins*/genetics , Neurons*/drug effects , Lithium*/pharmacology , Antimanic Agents*/pharmacology, Animals ; Disease Models, Animal ; Mice ; Male ; Mice, Inbred C57BL ; Neural Inhibition/drug effects

Harnessing GSK-3β inhibition for lung cancer therapy: emerging opportunities and challenges.

Authors: Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. emadhassanien@azhar.edu.eg., Althagafy HS; Division of Biochemistry, Department of Biological Sciences, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia., ElHafeez HHA; Department of Anatomy and Histology, Faculty of Veterinary Medicine, Assiut University, Asyut, Egypt., Ibrahim IM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt., Alghamdi BS; Neuroscience and Geroscience Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.; Department of Physiology, Faculty of Medicine, Neuroscience Unit, King Abdulaziz University, Jeddah, Saudi Arabia.

Source: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Nov 11; Vol. 42 (12), pp. 548. Date of Electronic Publication: 2025 Nov 11.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE

MeSH Terms: Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Lung Neoplasms*/drug therapy , Lung Neoplasms*/enzymology , Lung Neoplasms*/metabolism , Antineoplastic Agents*/therapeutic use , Antineoplastic Agents*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology, Humans ; Signal Transduction/drug effects ; Animals

Rational optimization of D3R/GSK-3β dual target-directed ligands as potential treatment for bipolar disorder: Design, synthesis, X-ray crystallography, molecular dynamics simulations, in vitro ADME, and in vivo pharmacokinetic studies.

Authors: Di Martino RMC; Computational and Chemical Biology, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy. Electronic address: rita.dimartino@uniupo.it., Russo D; D3 PharmaChemistry, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Penna I; D3 PharmaChemistry, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Demuro S; Computational and Chemical Biology, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy; Department of Pharmacy and Biotechnology, University of Bologna, via Belmeloro 6, 40126, Bologna (BO), Italy., Dalle Vedove A; Area Science Park, Padriciano 99, Trieste, Italy., Spagnuolo R; Department of Biomolecular Sciences, University of Urbino, Campus Scientifico Enrico Mattei, via Ca' Le Suore 2/4, 61029, Urbino (PU), Italy., Ottonello G; Analytical Chemistry Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Bertozzi SM; Analytical Chemistry Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Summa M; Translational Pharmacology Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Desantis J; Department of Chemistry, Biology and Biotechnology, University of Perugia, via dell'Elce di Sotto 8, 06123, Perugia (PG), Italy., Valeri A; Molecular Horizon srl, via Montelino 20, 06084, Bettona (PG), Italy., Pruccoli L; Department for Life Quality Studies, University of Bologna, Corso d'Augusto 237, 47921, Rimini (RN), Italy., Tripathi SK; Computational and Chemical Biology, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Tarozzi A; Department for Life Quality Studies, University of Bologna, Corso d'Augusto 237, 47921, Rimini (RN), Italy., Storici P; Protein Targets for Drug Discovery Lab, Structural Biology, Elettra Sincrotrone Trieste, SS 14 Km 163.5 in AREA Science Park, Basovizza, Trieste, Italy., Girotto S; Computational and Chemical Biology, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Bertorelli R; Translational Pharmacology Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Armirotti A; Analytical Chemistry Facility, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Cruciani G; Department of Chemistry, Biology and Biotechnology, University of Perugia, via dell'Elce di Sotto 8, 06123, Perugia (PG), Italy., Bandiera T; D3 PharmaChemistry, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy., Cavalli A; Computational and Chemical Biology, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova (GE), Italy; Department of Pharmacy and Biotechnology, University of Bologna, via Belmeloro 6, 40126, Bologna (BO), Italy., Bottegoni G; Department of Biomolecular Sciences, University of Urbino, Campus Scientifico Enrico Mattei, via Ca' Le Suore 2/4, 61029, Urbino (PU), Italy; School of Pharmacy, University of Birmingham, Edgbaston, B15 2TT, Birmingham, UK. Electronic address: giovanni.bottegoni@uniurb.it.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117899. Date of Electronic Publication: 2025 Jun 25.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

MeSH Terms: Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Drug Design* , Receptors, Dopamine D3*/metabolism , Receptors, Dopamine D3*/agonists , Bipolar Disorder*/drug therapy , Bipolar Disorder*/metabolism , Molecular Dynamics Simulation*, Humans ; Ligands ; Crystallography, X-Ray ; Animals ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug ; Male ; Rats

Targeting GSK-3β to Modulate the Wnt Pathway: A Promising Neuroprotective Strategy for Alzheimer's Disease.

Authors: Magham SV; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, TN, India., Shanavas S; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka575018, India., Pindiprolu SSSKS; Department of Pharmacology, School of Pharmacy, Aditya University, Surampalem 533437, India., Nagappan K; Department of Pharmaceutical Analysis, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, TN,India., More S; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka575018, India., Chaudhury D; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka575018, India., Ramakkamma AR; Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, TN, India., Singh MT; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, TN, India., Wadhwani A; Faculty of Health Sciences, School of Pharmacy, JSS Academy of Higher Education & Research, Vacoas-Phoenix 20201, Mauritius., Bose B; Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka575018, India., Thaggikuppe Krishnamurthy P; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty 643001, TN, India.; Department of Pharmacology, College of Pharmacy, JSS University, Noida 201301, U.P., India.

Source: Molecular pharmaceutics [Mol Pharm] 2025 Nov 03; Vol. 22 (11), pp. 6561-6574. Date of Electronic Publication: 2025 Oct 15.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

MeSH Terms: Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/pharmacokinetics , Neuroprotective Agents*/administration & dosage , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Indoles*/pharmacology , Indoles*/chemistry , Indoles*/pharmacokinetics , Indoles*/administration & dosage , Wnt Signaling Pathway*/drug effects , Oximes*/pharmacokinetics , Oximes*/chemistry , Oximes*/pharmacology , Oximes*/administration & dosage, Animals ; Rats ; Nanoparticles/chemistry ; Rats, Wistar ; Humans ; Male ; Tissue Distribution ; Brain/metabolism ; Brain/drug effects ; Stearic Acids/chemistry ; Cell Line, Tumor ; Drug Delivery Systems/methods ; Particle Size ; Liposomes

KDM1A Facilitates Oncogenic Potential in Colorectal Cancer Progression Through the Activation of AXIN/GSK3β/β-Catenin Signaling Pathways: Evidence From Integrated Transcriptomics and In Vitro Studies.

Authors: Natarajan SR; Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India., Krishnamoorthy R; Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia., Alshuniaber MA; Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia., Gatasheh MK; Department of Biochemistry, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia., Rajagopal P; Central Research Laboratory, Meenakshi Ammal Dental College and Hospital, Meenakshi, Academy of Higher Education and Research (Deemed to be University), Chennai, India., Veeraraghavan VP; Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India., Palanisamy CP; Phytochemistry and Pharmacotherapy Laboratory, Department of Dermatology, Saveetha Medical College & Hospital (SMCH), Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India., Jayaraman S; Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

Source: The journal of gene medicine [J Gene Med] 2025 Nov; Vol. 27 (11), pp. e70053.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 9815764 Publication Model: Print Cited Medium: Internet ISSN: 1521-2254 (Electronic) Linking ISSN: 1099498X NLM ISO Abbreviation: J Gene Med Subsets: MEDLINE

MeSH Terms: Colorectal Neoplasms*/genetics , Colorectal Neoplasms*/pathology , Colorectal Neoplasms*/metabolism , Histone Demethylases*/genetics , Histone Demethylases*/metabolism , beta Catenin*/metabolism , beta Catenin*/genetics , Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics, Humans ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Disease Progression ; Gene Expression Regulation, Neoplastic/drug effects ; Wnt Signaling Pathway ; Transcriptome ; Signal Transduction ; Epithelial-Mesenchymal Transition ; Glycolysis

GSK3β Regulates a Novel β-Catenin Degradation Pathway via the GID Complex in Wnt Signaling.

Authors: Shimizu M; Department of Molecular Cell Biology, Institute of Integrated Research, Medical Research Laboratory, Institute of Science Tokyo, Tokyo, Japan., Shibuya H; Department of Molecular Cell Biology, Institute of Integrated Research, Medical Research Laboratory, Institute of Science Tokyo, Tokyo, Japan.

Source: Genes to cells : devoted to molecular & cellular mechanisms [Genes Cells] 2025 Nov; Vol. 30 (6), pp. e70068.

Publication Type: Journal Article

Journal Info: Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 9607379 Publication Model: Print Cited Medium: Internet ISSN: 1365-2443 (Electronic) Linking ISSN: 13569597 NLM ISO Abbreviation: Genes Cells Subsets: MEDLINE

MeSH Terms: Glycogen Synthase Kinase 3 beta*/metabolism , Glycogen Synthase Kinase 3 beta*/genetics , beta Catenin*/metabolism , Wnt Signaling Pathway*, Humans ; Ubiquitination ; HEK293 Cells ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism

Advances in targeting glycogen synthase kinase 3β for diabetes therapy.

Authors: Wang F; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Li Y; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Bai L; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China., Xiao W; Department of Pharmacy, The General Hospital of Western Theater Command, Chengdu 610083, China. Electronic address: xwj-4321@163.com., Zhong L; Genetic Diseases Key Laboratory of Sichuan Province, Department of Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: zhonglingr@126.com., Shi J; Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China. Electronic address: shijianyoude@126.com.

Source: Bioorganic chemistry [Bioorg Chem] 2025 Nov; Vol. 166, pp. 109051. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

MeSH Terms: Glycogen Synthase Kinase 3 beta*/antagonists & inhibitors , Glycogen Synthase Kinase 3 beta*/metabolism , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/therapeutic use , Diabetes Mellitus, Type 2*/drug therapy , Diabetes Mellitus, Type 2*/metabolism , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/therapeutic use, Humans ; Animals ; Molecular Structure