MicroRNA-143 act as a tumor suppressor microRNA in human lung cancer cells by inhibiting cell proliferation, invasion, and migration

Συγγραφείς: Asghariazar, Vahid, Mansoori, Behzad, Kadkhodayi, Mahtab, Safarzadeh, Elham, Mohammadi, Ali, Baradaran, Behzad, Sakhinia, Ebrahim

Πηγή: Asghariazar, V, Mansoori, B, Kadkhodayi, M, Safarzadeh, E, Mohammadi, A, Baradaran, B & Sakhinia, E 2022, 'MicroRNA-143 act as a tumor suppressor microRNA in human lung cancer cells by inhibiting cell proliferation, invasion, and migration', Molecular Biology Reports, vol. 49, no. 8, pp. 7637-7647. https://doi.org/10.1007/s11033-022-07580-1

Θεματικοί όροι: 0301 basic medicine, Lung Neoplasms, Apoptosis, Replacement therapy, NSCLC, Metastasis, Cell Line, Cell Proliferation/genetics, 03 medical and health sciences, Invasion, Cell Movement, Carcinoma, Non-Small-Cell Lung/genetics, Apoptosis/genetics, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Cell Movement/genetics, MicroRNAs/metabolism, Humans, MicroRNA-143, Cell Proliferation, Metastasis, Invasion, Non-Small-Cell Lung/genetics, 0303 health sciences, Tumor, Signaling pathway, Carcinoma, MicroRNA, Neoplastic/genetics, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, MicroRNAs, Gene Expression Regulation, A549 Cells, Lung Neoplasms/metabolism

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/35717476
https://portal.findresearcher.sdu.dk/da/publications/b33f81f8-7600-43cd-9895-95a60ed4978b
https://doi.org/10.1007/s11033-022-07580-1

DNA methylation profile of inflammatory breast cancer and its impact on prognosis and outcome

Συγγραφείς: Faldoni, Flavia Lima Costa, Bizinelli, Daniela, Souza, Cristiano Pádua, Santana, Iara Viana Vidigal, Marques, Márcia Maria Chiquitelli, Rainho, Claudia Aparecida, Marchi, Fabio Albuquerque, Rogatto, Silvia Regina

Πηγή: Clin Epigenetics
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Faldoni, F L C, Bizinelli, D, Souza, C P, Santana, I V V, Marques, M M C, Rainho, C A, Marchi, F A & Rogatto, S R 2024, 'DNA methylation profile of inflammatory breast cancer and its impact on prognosis and outcome', Clinical Epigenetics, vol. 16, 89. https://doi.org/10.1186/s13148-024-01695-x

Θεματικοί όροι: Adult, 0301 basic medicine, Inflammatory Breast Neoplasms/genetics, Differentially methylated sites, QH426-470, epigenetic regulation, Epigenesis, Genetic, 03 medical and health sciences, Genetics, Biomarkers, Tumor, Humans, Genetic/genetics, Aged, 0303 health sciences, DNA methylation, Research, Driver mutations, Epigenesis, Genetic/genetics, Neoplastic/genetics, Biomarker, DNA Methylation, Middle Aged, Prognosis, CpG Islands/genetics, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, Gene Expression Regulation, DNA methylation, epigenetic regulation, Tumor/genetics, Medicine, Female, CpG Islands, Inflammatory Breast Neoplasms, Gene expression, Biomarkers, Tumor/genetics, Biomarkers, DNA Methylation/genetics, Epigenesis

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38971778
https://doaj.org/article/c57b38a139e04053a7a02ac9ce2ee32f
https://portal.findresearcher.sdu.dk/da/publications/168bca64-cb45-471a-a9a0-5e290bc8ccff
https://doi.org/10.1186/s13148-024-01695-x
https://portal.findresearcher.sdu.dk/da/publications/168bca64-cb45-471a-a9a0-5e290bc8ccff
https://doi.org/10.1186/s13148-024-01695-x
https://findresearcher.sdu.dk/ws/files/267713942/Open_Access_Version.pdf

The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis

Συγγραφείς: Di Grazia, Antonio, Marafini, Irene, Pedini, Giorgia, Di Fusco, Davide, Laudisi, Federica, Dinallo, Vincenzo, Rosina, Eleonora, Stolfi, Carmine, Franze, Eleonora, Sileri, Pierpaolo, Sica, Giuseppe, Monteleone, Giovanni, Bagni, Claudia, Monteleone, Ivan

Συνεισφορές: Di Grazia, A, Marafini, I, Pedini, G, Di Fusco, D, Laudisi, F, Dinallo, V, Rosina, E, Stolfi, C, Franzè, E, Sileri, P, Sica, G, Monteleone, G, Bagni, C, Monteleone, I

Πηγή: Cell Mol Gastroenterol Hepatol
Cellular and molecular gastroenterology and hepatology.-2020
Cellular and molecular gastroenterology and hepatology, vol. 11, no. 2, pp. 639-658

Θεματικοί όροι: Male, 0301 basic medicine, Carcinogenesis, Settore MED/18 - CHIRURGIA GENERALE, Cell Culture Techniques, Datasets as Topic, Settore MEDS-06/A - Chirurgia generale, Mice, ELEMENTS, IN-VIVO, Original Research, Mice, Knockout, 0303 health sciences, CREB, INDUCTION, NECROSIS, Prognosis, Healthy Volunteers, APOPTOSIS, 3. Good health, Organoids, Gene Expression Regulation, Neoplastic, Receptor-Interacting Protein Serine-Threonine Kinases, Gene Knockdown Techniques, Necroptosis, Animals, Azoxymethane/administration & dosage, Azoxymethane/toxicity, Carcinogenesis/genetics, Case-Control Studies, Cell Line, Tumor, Colon/pathology, Colon/surgery, Colorectal Neoplasms/chemically induced, Colorectal Neoplasms/genetics, Colorectal Neoplasms/mortality, Colorectal Neoplasms/surgery, Disease-Free Survival, Fragile X Mental Retardation Protein/antagonists & inhibitors, Fragile X Mental Retardation Protein/genetics, Fragile X Mental Retardation Protein/metabolism, Gene Expression Regulation, Neoplastic/drug effects, Gene Expression Regulation, Neoplastic/genetics, Humans, Necroptosis/genetics, Neoplasm Recurrence, Local/epidemiology, Neoplasm Recurrence, Local/genetics, Neoplasms, Experimental/chemically induced, Neoplasms, Experimental/genetics, Neoplasms, Experimental/pathology, Receptor-Interacting Protein Serine-Threonine Kinases/genetics, Colorectal Cancer, FMRP, RIPK, Colorectal Neoplasms, Life Sciences & Biomedicine, Necroptosi, 3101 Biochemistry and cell biology, RNA-BINDING PROTEINS, Colon, Azoxymethane, BIOLOGY, 03 medical and health sciences, Science & Technology, Fragile X Messenger Ribonucleoprotein 1, Gastroenterology & Hepatology, 3202 Clinical sciences, Neoplasms, Experimental, CELL-DEATH, Neoplasm Recurrence, Local

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: http://www.cmghjournal.org/article/S2352345X20301727/pdf
https://pubmed.ncbi.nlm.nih.gov/33091622
https://sonar.ch/global/documents/972
https://serval.unil.ch/resource/serval:BIB_33BB140AE8AC.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_33BB140AE8AC8
https://serval.unil.ch/notice/serval:BIB_33BB140AE8AC

Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse

Συγγραφείς: Francesca Chemi, Dominic G. Rothwell, Nicholas McGranahan, Sakshi Gulati, Chris Abbosh, Simon P. Pearce, Cong Zhou, Gareth A. Wilson, Mariam Jamal-Hanjani, Nicolai Birkbak, Jackie Pierce, Chang Sik Kim, Saba Ferdous, Deborah J. Burt, Daniel Slane-Tan, Fabio Gomes, David Moore, Rajesh Shah, Maise Al Bakir, Crispin Hiley, Selvaraju Veeriah, Yvonne Summers, Philip Crosbie, Sophia Ward, Barbara Mesquita, Marek Dynowski, Dhruva Biswas, Jonathan Tugwood, Fiona Blackhall, Crispin Miller, Allan Hackshaw, Ged Brady, Charles Swanton, Caroline Dive

Πηγή: TRACERx Consortium 2019, 'Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse', Nature Medicine, vol. 25, no. 10, pp. 1534-1539. https://doi.org/10.1038/s41591-019-0593-1

Θεματικοί όροι: Adult, Male, 0301 basic medicine, Carcinoma, Non-Small-Cell Lung/diagnosis, Neoplastic Cells, Local/diagnosis, Neoplasm Recurrence, Local/diagnosis, 03 medical and health sciences, Carcinoma, Non-Small-Cell Lung, 80 and over, Biomarkers, Tumor, Humans, Neoplasm Metastasis, Neoplastic Cells, Circulating/pathology, Aged, Neoplasm Staging, Aged, 80 and over, 0303 health sciences, Genome, Human/genetics, Non-Small-Cell Lung/diagnosis, Genome, Human, Carcinoma, Neoplastic/genetics, Middle Aged, Neoplastic Cells, Circulating, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, Neoplasm Recurrence, Gene Expression Regulation, Pulmonary Veins, Genome, Human/genetics, Tumor/genetics, Female, Pulmonary Veins/pathology, Biomarkers, Tumor/genetics, Neoplasm Recurrence, Local, Biomarkers, Circulating/pathology

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc6986897?pdf=render
https://pubmed.ncbi.nlm.nih.gov/31591595
https://research.manchester.ac.uk/en/publications/cce189d9-1bac-4d24-8889-3c9a577a7da6
https://doi.org/10.1038/s41591-019-0593-1
https://research.manchester.ac.uk/en/publications/cce189d9-1bac-4d24-8889-3c9a577a7da6
https://discovery.ucl.ac.uk/id/eprint/10083787/
https://doi.org/10.1038/s41591-019-0593-1

Molecular landmarks of tumor hypoxia across cancer types

Συγγραφείς: Vinayak Bhandari, Christianne Hoey, Lydia Y. Liu, Emilie Lalonde, Jessica Ray, Julie Livingstone, Robert Lesurf, Yu-Jia Shiah, Tina Vujcic, Xiaoyong Huang, Shadrielle M. G. Espiritu, Lawrence E. Heisler, Fouad Yousif, Vincent Huang, Takafumi N. Yamaguchi, Cindy Q. Yao, Veronica Y. Sabelnykova, Michael Fraser, Melvin L. K. Chua, Theodorus van der Kwast, Stanley K. Liu, Paul C. Boutros, Robert G. Bristow

Πηγή: Bhandari, V, Hoey, C, Liu, L Y, Lalonde, E, Ray, J, Livingstone, J, Lesurf, R, Shiah, Y-J, Vujcic, T, Huang, X, Espiritu, S M G, Heisler, L E, Yousif, F, Huang, V, Yamaguchi, T N, Yao, C Q, Sabelnykova, V Y, Fraser, M, Chua, M L K, van der Kwast, T, Liu, S K, Boutros, P C & Bristow, R G 2019, 'Molecular landmarks of tumor hypoxia across cancer types', Nature Genetics, vol. 51, no. 2, pp. 308-318. https://doi.org/10.1038/s41588-018-0318-2

Θεματικοί όροι: Male, 0301 basic medicine, Lydia Becker Institute, Tumor Hypoxia/genetics, Genomic Instability, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Hypoxia/genetics, Humans, Hypoxia, Alleles, Telomere/genetics, Chromothripsis, Tumor, Manchester Cancer Research Centre, Prostatic Neoplasms/genetics, Gene Expression Profiling, PTEN Phosphohydrolase, PTEN Phosphohydrolase/genetics, Prostatic Neoplasms, Neoplastic/genetics, Telomere, ResearchInstitutes_Networks_Beacons/mcrc, name=Manchester Cancer Research Centre, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, MicroRNAs/genetics, MicroRNAs, Gene Expression Regulation, PC-3 Cells, Tumor Hypoxia, Gene Expression Profiling/methods, Genomic Instability/genetics, ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation, name=Lydia Becker Institute

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/30643250

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Συγγραφείς: Annalisa Ferino, Giulia Miglietta, Raffaella Picco, Stefan Vogel, Jesper Wengel, Luigi E. Xodo

Πηγή: RNA Biol
Ferino, A, Miglietta, G, Picco, R, Vogel, S, Wengel, J & Xodo, L E 2018, 'MicroRNA therapeutics : design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells', RNA Biology, vol. 15, no. 10, pp. 1273-1285. https://doi.org/10.1080/15476286.2018.1526536

Θεματικοί όροι: 0301 basic medicine, AGO2, KRAS, miR-216b, PDAC cells, POPC liposome, Molecular Biology, Cell Biology, Pancreatic Ductal/genetics, Carcinoma, Pancreatic Ductal/genetics, Lipids/chemistry, Cell Line, Proto-Oncogene Proteins p21(ras), Cell Proliferation/genetics, 03 medical and health sciences, MicroRNAs/chemistry, Cell Line, Tumor, Argonaute Proteins/genetics, Humans, 3' Untranslated Regions, Pancreas, Cell Proliferation, Pancreas/metabolism, 0303 health sciences, Tumor, Carcinoma, Neoplastic/genetics, Nanoparticles/administration & dosage, Lipids, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, MicroRNAs, Gene Expression Regulation, 3' Untranslated Regions/genetics, Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors, Argonaute Proteins, Liposomes, Nanoparticles, Liposomes/chemistry, Research Paper, Carcinoma, Pancreatic Ductal

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.tandfonline.com/doi/pdf/10.1080/15476286.2018.1526536?needAccess=true
https://pubmed.ncbi.nlm.nih.gov/30306823
https://findresearcher.sdu.dk/ws/files/144402099/MicroRNA_therapeutics_design_of_single_stranded_miR_216b_mimics_to_target_KRAS_in_pancreatic_cancer_cells.pdf
https://portal.findresearcher.sdu.dk/da/publications/0511dac2-b292-4c3f-a7b2-c3433ca43470
https://doi.org/10.1080/15476286.2018.1526536
https://portal.findresearcher.sdu.dk/da/publications/0511dac2-b292-4c3f-a7b2-c3433ca43470
https://doi.org/10.1080/15476286.2018.1526536
https://hdl.handle.net/11390/1140280
https://doi.org/10.1080/15476286.2018.1526536
https://hdl.handle.net/11585/968927
https://doi.org/10.1080/15476286.2018.1526536

Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors

Συγγραφείς: Armento, Angela, ILINA, Elena, Kaoma, Tony, Muller, Arnaud, Vallar, Laurent, NICLOU, Simone P., Krüger, Marcel A, MITTELBRONN, Michel, Naumann, Ulrike

Πηγή: International Journal of Oncology, 51 (2), 702-714 (2017-08)

Θεματικοί όροι: RNA, Messenger/genetics, 0301 basic medicine, Oncologie, Carboxypeptidase H/genetics, Sciences de la santé humaine, Mice, 03 medical and health sciences, Neoplasm Proteins/genetics, Cell Movement, Cell Line, Tumor, Cell Movement/genetics, Animals, Humans, Neoplasm Invasiveness, RNA, Messenger, Human health sciences, 0303 health sciences, Gene Expression Profiling, Carboxypeptidase H, Neoplasm Invasiveness/genetics/pathology, Xenograft Model Antitumor Assays, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, Oncology, Signal Transduction/genetics, EC 3.4.17.10 (Carboxypeptidase H), Glioblastoma/genetics/pathology, Glioblastoma, Signal Transduction

Σύνδεσμος πρόσβασης: https://www.spandidos-publications.com/10.3892/ijo.2017.4051/download
https://pubmed.ncbi.nlm.nih.gov/28656234
https://orbilu.uni.lu/handle/10993/60418
https://orbilu.uni.lu/bitstream/10993/60418/1/ijo_51_2_702_PDF.pdf

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

Συγγραφείς: Cejas,Paloma, Xie,Yingtian, Font-Tello,Alba, Lim,Klothilda, Syamala,Sudeepa, Qiu,Xintao, Tewari,Alok K, Shah,Neel, Nguyen,Holly M, Patel,Radhika A, Brown,Lisha, Coleman,Ilsa, Hackeng, Wenzel M, Brosens, Lodewijk, Dreijerink, Koen M A, Ellis,Leigh, Alaiwi,Sarah Abou, Seo,Ji-Heui, Baca,Sylvan, Beltran,Himisha, Khani,Francesca, Pomerantz,Mark, Dall'Agnese,Alessandra, Crowdis,Jett, Van Allen,Eliezer M, Bellmunt,Joaquim, Morrisey,Colm, Nelson,Peter S, DeCaprio,James, Farago,Anna, Dyson,Nicholas, Drapkin,Benjamin, Liu,X Shirley, Freedman,Matthew, Haffner,Michael C, Corey,Eva, Brown,Myles, Long,Henry W, Pathologie Groep Brosens, Cancer, Pathologie Pathologen staf

Συνεισφορές: Pathologie Groep Brosens, Cancer, Pathologie Pathologen staf

Θεματικοί όροι: Male, Basic Helix-Loop-Helix Transcription Factors/genetics, Chromatin/genetics, Prostatic Neoplasms/genetics, Research Support, Non-U.S. Gov't, General Biochemistry,Genetics and Molecular Biology, Transcription Factors/genetics, General Physics and Astronomy, Epigenesis, Genetic/genetics, General Chemistry, Gene Expression Regulation, Neoplastic/genetics, Carcinoma, Neuroendocrine/genetics, Research Support, N.I.H., Extramural, Journal Article, Humans, Research Support, U.S. Gov't, Non-P.H.S

Περιγραφή αρχείου: application/pdf; text/plain

Σύνδεσμος πρόσβασης: https://dspace.library.uu.nl/handle/1874/443784

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

Συγγραφείς: Debackere, Koen, Marcelis, Lukas, Demeyer, Sofie, Vanden Bempt, Marlies, Mentens, Nicole, Gielen, Olga, Jacobs, Kris, Broux, Michael, Verhoef, Gregor, Michaux, Lucienne, Graux, Carlos, Wlodarska, Iwona, Gaulard, Philippe, de Leval, Laurence, Tousseyn, Thomas, Cools, Jan, Dierickx, Daan

Συνεισφορές: UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie

Πηγή: Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature communications, Vol. 12, no.1, p. 3705 (2021)
Nature communications, vol. 12, no. 1, pp. 3705

Θεματικοί όροι: EXPRESSION, 0301 basic medicine, Oncogene Proteins, Fusion, Science, NF-KAPPA-B, Receptors, Antigen, T-Cell, bcl-X Protein, Kaplan-Meier Estimate, Proto-Oncogene Proteins c-fyn, Article, ACTIVATION, Cohort Studies, Mice, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, RNA-Seq, Adaptor Proteins, Signal Transducing, DASATINIB, 0303 health sciences, Science & Technology, IDENTIFICATION, MUTATIONS, Forkhead Box Protein O1, Cell Membrane, Intracellular Signaling Peptides and Proteins, NF-kappa B, Lymphoma, T-Cell, Peripheral, RNA-Binding Proteins, DRIVEN, GENE, 3. Good health, Multidisciplinary Sciences, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Sin3 Histone Deacetylase and Corepressor Complex, TARGET, P56LCK, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Science & Technology - Other Topics, Adaptor Proteins, Signal Transducing/genetics, Adaptor Proteins, Signal Transducing/metabolism, Cell Membrane/metabolism, DNA-Binding Proteins/genetics, DNA-Binding Proteins/metabolism, Forkhead Box Protein O1/genetics, Forkhead Box Protein O1/metabolism, Gene Expression Regulation, Neoplastic/genetics, Intracellular Signaling Peptides and Proteins/metabolism, Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics, Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/metabolism, Lymphoma, T-Cell, Peripheral/pathology, NF-kappa B/metabolism, Oncogene Proteins, Fusion/genetics, Oncogene Proteins, Fusion/metabolism, Proto-Oncogene Proteins c-fyn/genetics, Proto-Oncogene Proteins c-fyn/metabolism, RNA-Binding Proteins/genetics, RNA-Binding Proteins/metabolism, Receptors, Antigen, T-Cell/metabolism, Signal Transduction/genetics, Sin3 Histone Deacetylase and Corepressor Complex/genetics, Sin3 Histone Deacetylase and Corepressor Complex/metabolism, bcl-X Protein/antagonists & inhibitors, bcl-X Protein/metabolism, Signal Transduction

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41467-021-24037-4.pdf
https://pubmed.ncbi.nlm.nih.gov/34140493
https://doaj.org/article/969eed6176e84cfbb86762c9aa0218ee
https://lirias.kuleuven.be/handle/123456789/676978
https://doi.org/10.1038/s41467-021-24037-4
https://hdl.handle.net/2078.1/270379
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F9F211DA31327
https://serval.unil.ch/resource/serval:BIB_F9F211DA3132.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_F9F211DA3132

TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features

Συγγραφείς: Castanheira, A, Vieira, MJ, Pinto, M, Dias, C, Prada, L, Macedo, S, Fernandes, MS, Vieira, F, Soares, P, Mota, AV, Lopes, JM, Boaventura, P

Συνεισφορές: Instituto de Investigação e Inovação em Saúde

Πηγή: Sci Rep
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)

Θεματικοί όροι: Male, Mutation / genetics, Skin Neoplasms, Science, Carcinoma, Basal Cell / pathology, Article, 03 medical and health sciences, 0302 clinical medicine, Humans, Telomerase / genetics, Promoter Regions, Genetic, Telomerase, Skin Neoplasms / genetics, Carcinoma, Basal Cell / genetics, Aged, Skin Neoplasms / pathology, Head and Neck Neoplasms / genetics, Head and Neck Neoplasms / pathology, Tumor Suppressor Protein p53 / genetics, 3. Good health, Carcinoma, Basal Cell / classification, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic / genetics, Head and Neck Neoplasms, Head and Neck Neoplasms / classification, Mutation, Medicine, Female, Tumor Suppressor Protein p53, Basal Cell Carcinoma

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41598-021-89906-w.pdf
https://pubmed.ncbi.nlm.nih.gov/34001963
https://doaj.org/article/11b0c3808fd0411c92da54a70d584677
https://hdl.handle.net/10216/152503

The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype

Συγγραφείς: Marta Montes, Michal Lubas, Frederic S. Arendrup, Bettina Mentz, Neha Rohatgi, Sarunas Tumas, Lea M. Harder, Anders J. Skanderup, Jens S. Andersen, Anders H. Lund

Συνεισφορές: Dadun. Depósito Académico Digital Universidad de Navarra

Πηγή: Nat Commun
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Montes, M, Lubas, M, Arendrup, F S, Mentz, B, Rohatgi, N, Tumas, S, Harder, L M, Skanderup, A J, Andersen, J S & Lund, A H 2021, ' The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype ', Nature Communications, vol. 12, no. 1, 2459, pp. 1-17 . https://doi.org/10.1038/s41467-021-22746-4
Montes, M, Lubas, M, Arendrup, F S, Mentz, B, Rohatgi, N, Tumas, S, Harder, L M, Skanderup, A J, Andersen, J S & Lund, A H 2021, 'The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype', Nature Communications, vol. 12, no. 1, 2459. https://doi.org/10.1038/s41467-021-22746-4

Θεματικοί όροι: Proto-Oncogene Proteins B-raf, 0301 basic medicine, Aging, Science, Cell Transformation, Ribosomal Protein S6 Kinases, 90-kDa, Article, Cell Line, Cell Proliferation/genetics, 03 medical and health sciences, Long Noncoding/genetics, 90-kDa/metabolism, MIR31HG, Neoplasms, Aging/genetics, Humans, RNA, Long Noncoding/genetics, Phosphorylation, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Ribosomal Protein S6 Kinases, Cell Transformation, Neoplastic/genetics, Cyclin-Dependent Kinase Inhibitor p16/biosynthesis, Neoplastic/genetics, Senescence associated secretory phenotype, Neoplasms/genetics, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, Proto-Oncogene Proteins B-raf/metabolism, Cell Transformation, Neoplastic, Gene Expression Regulation, Cellular Senescence/genetics, Ribosomal Protein S6 Kinases, 90-kDa/metabolism, RNA, RNA, Long Noncoding, Y-Box-Binding Protein 1, Y-Box-Binding Protein 1/metabolism

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/s41467-021-22746-4.pdf
https://pubmed.ncbi.nlm.nih.gov/33911076
https://doaj.org/article/8da6f54bfa9d4666b2534cafaba5a56a
https://hdl.handle.net/10171/122070
https://curis.ku.dk/ws/files/269512038/s41467_021_22746_4.pdf
https://researchprofiles.ku.dk/da/publications/0a1643e6-dc80-46ad-b1fb-416ec3e624a3
https://doi.org/10.1038/s41467-021-22746-4
https://findresearcher.sdu.dk/ws/files/182422364/s41467_021_22746_4.pdf
https://portal.findresearcher.sdu.dk/da/publications/d515a39c-f9b2-445a-b6d8-1805bb7b26bc
https://doi.org/10.1038/s41467-021-22746-4
https://portal.findresearcher.sdu.dk/da/publications/d515a39c-f9b2-445a-b6d8-1805bb7b26bc
https://doi.org/10.1038/s41467-021-22746-4

The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment.

Συγγραφείς: Renaude, Elodie, Kroemer, Marie, Loyon, Romain, Binda, Delphine, Borg, Christophe, Guittaut, Michaël, Hervouet, Eric, Peixoto, Paul

Πηγή: International Journal of Molecular Sciences, 21 (5), 1673 (2020-02-29)

Θεματικοί όροι: TIL, Th17 cells, epigenetic modifications, Cell Differentiation/immunology, Gene Expression Regulation, Neoplastic/genetics, Tumor Microenvironment/immunology, Cell Differentiation, Life sciences, Biochemistry, biophysics & molecular biology, Sciences du vivant, Biochimie, biophysique & biologie moléculaire

Relation: https://www.mdpi.com/1422-0067/21/5/1673/pdf; urn:issn:1661-6596; urn:issn:1422-0067

Σύνδεσμος πρόσβασης: https://orbi.uliege.be/handle/2268/330768

Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma

Συγγραφείς: Choi, CL, Fung, TK, Chim, CS, Liang, R, Pang, R

Πηγή: Leukemia. 21:2527-2536

Θεματικοί όροι: Adult, Male, 0301 basic medicine, Neoplasm - chemistry - genetics, Molecular Sequence Data, Neoplasm Proteins - genetics - physiology, Tumor - drug effects - metabolism, Intercellular Signaling Peptides and Proteins - genetics - metabolism, Decitabine, Cell Line, Multiple Myeloma - genetics - metabolism - pathology, 03 medical and health sciences, Adaptor Proteins, Signal Transducing - genetics - metabolism, Signal Transducing - genetics - metabolism, Cell Line, Tumor, DNA, Neoplasm - chemistry - genetics, 80 and over, Azacitidine - analogs & derivatives - pharmacology, Humans, Gene Silencing, Phosphorylation, Wnt Proteins - physiology, Protein Processing, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, 0303 health sciences, Base Sequence, Post-Translational, Adaptor Proteins, DNA, DNA, Neoplasm, DNA Methylation, Middle Aged, beta Catenin - chemistry, Neoplastic - genetics, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Cell Line, Tumor - drug effects - metabolism, Azacitidine, Gene Expression Regulation, Neoplastic - genetics, Intercellular Signaling Peptides and Proteins, Female, Recombinant Proteins - pharmacology, Multiple Myeloma, Protein Processing, Post-Translational, Signal Transduction - genetics

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/2404939.pdf
https://pubmed.ncbi.nlm.nih.gov/17882284
http://hdl.handle.net/10722/77408
http://hdl.handle.net/10722/102904

KLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment

Συγγραφείς: von Spreckelsen, Niklas, Waldt, Natalie, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, E. Antonio, Huettelmaier, Stefan, Poetschke, Rebecca, Acker, Till, Mawrin, Christian, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Schob, Stefan, Scherlach, Cordula, Sandalcioglu, Ibrahim Erol

Πηγή: Acta Neuropathol Commun
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-11 (2020)
Acta Neuropathologica Communications 8(1), 41 (2020). doi:10.1186/s40478-020-00912-x

Θεματικοί όροι: 0301 basic medicine, Kruppel-Like Transcription Factors: genetics, Sirolimus: analogs & derivatives, Mechanistic Target of Rapamycin Complex 1: antagonists & inhibitors, Mice, Meningeal Neoplasms, Edema, RNA-Seq, Hypoxia, 0303 health sciences, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Regulation, Neoplastic: genetics, Hypoxia: metabolism, Meningioma: metabolism, Up-Regulation, 3. Good health, Meningioma: genetics, Gene Expression Regulation, Neoplastic, K409Q, Hypoxia-Inducible Factor 1, alpha Subunit: genetics, Gene Expression Regulation, Neoplastic: drug effects, Meningioma, Signal Transduction, Kruppel-Like Transcription Factors, Mice, Nude, Mechanistic Target of Rapamycin Complex 1, Hypoxia: genetics, Skull Base Neoplasms, Prolyl Hydroxylases, Protein Kinase Inhibitors: pharmacology, Kruppel-Like Factor 4, 03 medical and health sciences, Cell Line, Tumor, HIF, Animals, Humans, Meningeal Neoplasms: genetics, Tumor Hypoxia: genetics, RC346-429, Protein Kinase Inhibitors, Cell Proliferation, Research, Hypoxia-Inducible Factor 1, alpha Subunit: metabolism, Kruppel-Like Transcription Factors: drug effects, Hypoxia-Inducible Factor 1, alpha Subunit, Mutation, Meningeal Neoplasms: metabolism, Sirolimus: pharmacology, Neurology. Diseases of the nervous system, Hypoxia-Inducible Factor 1, alpha Subunit: drug effects, Neoplasm Transplantation

Σύνδεσμος πρόσβασης: https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-020-00912-x
https://pubmed.ncbi.nlm.nih.gov/32245394
https://doaj.org/article/d4df8fe0044b413a9a939983769aa2cb
https://pub.dzne.de/record/151518

Putative cis-regulatory drivers in colorectal cancer

Συγγραφείς: Ongen Halit, Andersen Claus L, Bramsen Jesper B, Oster Bodil, Rasmussen Mads H, Ferreira Pedro G, Sandoval Juan, Vidal Enrique, Whiffin Nicola, Planchon Alexandra, Padioleau Ismael, Bielser Deborah, Romano Luciana, Tomlinson Ian, Houlston Richard S, Esteller Manel, Orntoft Torben F, Dermitzakis Emmanouil T

Πηγή: Nature.-2014
Ongen, H, Andersen, C L, Bramsen, J B, Oster, B, Rasmussen, M H, Ferreira, P G, Sandoval, J, Vidal, E, Whiffin, N, Planchon, A, Padioleau, I, Bielser, D, Romano, L, Tomlinson, I, Houlston, R S, Esteller, M, Orntoft, T F & Dermitzakis, E T 2014, 'Putative cis-regulatory drivers in colorectal cancer', Nature, vol. 512, no. 7512, pp. 87-90. https://doi.org/10.1038/nature13602
Nature

Θεματικοί όροι: 576.5, 0301 basic medicine, Genotype, Quantitative Trait Loci, Regulatory Sequences, Nucleic Acid, Germ-Line Mutation/genetics, 03 medical and health sciences, Humans, Transcription Factors/metabolism, Intestinal Mucosa, Intestinal Mucosa/cytology/metabolism/pathology, Alleles, Germ-Line Mutation, 0303 health sciences, Colorectal Neoplasms/genetics/pathology, Sequence Analysis, RNA, Gene Expression Profiling, Cell Transformation, Neoplastic/genetics/pathology, Regulatory Sequences, Nucleic Acid/genetics, Transcriptome/genetics, DNA Methylation, 3. Good health, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, Cell Transformation, Neoplastic, Quantitative Trait Loci/genetics, Colorectal Neoplasms, Transcriptome, Genes, Neoplasm, Genome-Wide Association Study, Transcription Factors

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/25079323
https://sonar.ch/global/documents/240557

The Parkinson’s gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes

Συγγραφείς: O’ Flanagan, Ciara, Morais, Vanessa, Wurst, Wolfgang, De Strooper, Bart, O’ Neill, Cora

Πηγή: Oncogene 34(11), 1363-1374 (2015). doi:10.1038/onc.2014.81

Θεματικοί όροι: 0301 basic medicine, Protein Kinases: biosynthesis, Cell Division: genetics, Mitochondria: pathology, M Phase Cell Cycle Checkpoints: genetics, DISEASE, Protein Kinases: genetics, GTP Phosphohydrolases, PROTECTS, Mice, Parkinson Disease: genetics, Cell Movement, Cyclin D1, OXIDATIVE STRESS, RNA, Small Interfering, PHOSPHORYLATION, Genetics & Heredity, Mice, Knockout, 2. Zero hunger, 0303 health sciences, Parkinson Disease, Gene Expression Regulation, Neoplastic: genetics, APOPTOSIS, Mitochondria, 3. Good health, Gene Expression Regulation, Neoplastic, Oncology, GTP Phosphohydrolases: metabolism, MCF-7 Cells, GROWTH, RNA Interference, PTEN-induced putative kinase, Life Sciences & Biomedicine, Microtubule-Associated Proteins, Cell Division, Dynamins, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology, MITOCHONDRIAL FISSION, Mitochondria: genetics, DRP1, Mitochondrial Proteins, 03 medical and health sciences, DNM1L protein, human, 3211 Oncology and carcinogenesis, Cell Line, Tumor, Animals, Humans, 1112 Oncology and Carcinogenesis, Mitochondrial Proteins: metabolism, Neoplasm Invasiveness, Oncology & Carcinogenesis, Cell Proliferation: genetics, Cell Proliferation, Cytokinesis, PTEN-Induced Putative Kinase, Microtubule-Associated Proteins: metabolism, Science & Technology, Protein Kinases: metabolism, Cytokinesis: genetics, MUTATIONS, Neoplasm Invasiveness: genetics, PINK1, CCND1 protein, human, 1103 Clinical Sciences, Cell Biology, DYSFUNCTION, Hela Cells, Cyclin D1: biosynthesis, M Phase Cell Cycle Checkpoints, Protein Kinases, HeLa Cells

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/onc201481.pdf
https://pubmed.ncbi.nlm.nih.gov/24681957
https://pub.dzne.de/record/137816
https://lirias.kuleuven.be/handle/123456789/444632
https://doi.org/10.1038/onc.2014.81

JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells

Συγγραφείς: Walters, Z S, Villarejo-Balcells, B, Olmos, D, Buist, T W S, Missiaglia, E, Allen, R, Al-Lazikani, B, Garrett, M D, Blagg, J, Shipley, J

Πηγή: Oncogene
Oncogene.-2014
Oncogene, vol. 33, no. 9, pp. 1148-1157

Θεματικοί όροι: 0301 basic medicine, Oncogene Proteins, Fusion, Transcription, Genetic, Promyelocytic Leukemia Protein, Q1, Muscle Development, Article, 03 medical and health sciences, Cell Line, Tumor, Rhabdomyosarcoma, Humans, Paired Box Transcription Factors, Enhancer of Zeste Homolog 2 Protein, Promoter Regions, Genetic, Cell Proliferation, Histone Demethylases, 0303 health sciences, Tumor Suppressor Proteins, Polycomb Repressive Complex 2, Nuclear Proteins, Cell Differentiation, Gene Expression Regulation, Neoplastic, Myogenin, Cell Differentiation/genetics, Gene Expression Regulation, Neoplastic/genetics, Histone Demethylases/genetics, Histone Demethylases/metabolism, Muscle Development/genetics, Myogenin/genetics, Myogenin/metabolism, Nuclear Proteins/genetics, Nuclear Proteins/metabolism, Oncogene Proteins, Fusion/genetics, Oncogene Proteins, Fusion/metabolism, Paired Box Transcription Factors/genetics, Paired Box Transcription Factors/metabolism, Polycomb Repressive Complex 2/genetics, Polycomb Repressive Complex 2/metabolism, Promoter Regions, Genetic/genetics, Rhabdomyosarcoma/genetics, Rhabdomyosarcoma/pathology, Transcription Factors/genetics, Transcription Factors/metabolism, Transcription, Genetic/genetics, Tumor Suppressor Proteins/genetics, Tumor Suppressor Proteins/metabolism, Transcription Factors

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://www.nature.com/articles/onc201346.pdf
https://pubmed.ncbi.nlm.nih.gov/23435416
https://sonar.ch/global/documents/266290
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_DA4FFBE68A201
https://serval.unil.ch/notice/serval:BIB_DA4FFBE68A20
https://serval.unil.ch/resource/serval:BIB_DA4FFBE68A20.P001/REF.pdf

Expression of ERCC1 and its clinicopathological correlations in non-small cell lung cancer

Συγγραφείς: Çetin, Gökhan Ozan, Büyükpınarbaşılı, N., Elmas, Levent, Tepeli, Emre, Caner, Vildan, Bağcı, Gülseren, Düzcan, Füsun

Πηγή: Molecular Biology Reports. 39:335-341

Θεματικοί όροι: Male, excision repair cross complementing group 1 gene, genetic association, 0302 clinical medicine, Non-small cell lung cancer, molecular pathology, oncogene, Carcinoma, Non-Small-Cell Lung, Aged, Carcinoma, Non-Small-Cell Lung/*genetics/pathology, DNA, Complementary/genetics, DNA-Binding Proteins/*genetics/*metabolism, Endonucleases/*genetics/*metabolism, Female, Gene Expression Regulation, Neoplastic/*genetics, Genetic Markers/*genetics, Humans, Immunohistochemistry, Middle Aged, Nucleic Acid Amplification Techniques, RNA, Messenger/*genetics, Real-Time Polymerase Chain Reaction, messenger RNA, lung non small cell cancer, article, gene expression regulation, 3. Good health, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, aged, female, real time polymerase chain reaction, immunohistochemistry, histopathology, genetic marker, down regulation, Genetic Markers, DNA, Complementary, DNA repair, Real-time quantitative PCR, 03 medical and health sciences, male, controlled study, human, RNA, Messenger, protein expression, gene identification, excision repair cross complementing protein 1, cancer staging, DNA, Endonucleases, major clinical study, human tissue, clinical feature, gene function, validation process, ERCC1, upregulation, IHC

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/21553054
https://hdl.handle.net/11499/8780
https://doi.org/10.1007/s11033-011-0743-0
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/8780
https://aperta.ulakbim.gov.tr/record/85197

Global Regulation on microRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma

Συγγραφείς: Luk, JM, Fan, ST, Poon, RT, Liu, AM, Zhang, C, Burchard, J, Wong, KF, Dai, H

Συνεισφορές: CANCER SCIENCE INSTITUTE OF SINGAPORE

Πηγή: OMICS: A Journal of Integrative Biology. 15:187-191

Θεματικοί όροι: 0301 basic medicine, Hepatitis B virus - physiology, Hepatitis B virus, 0303 health sciences, Carcinoma, Hepatocellular, Carcinoma, Liver Neoplasms, Gene Dosage, Neoplastic - genetics, Hepatocellular - genetics - virology, 3. Good health, Gene Expression Regulation, Neoplastic, MicroRNAs, 03 medical and health sciences, Gene Expression Regulation, Gene Expression Regulation, Neoplastic - genetics, Humans, MicroRNAs - genetics, Liver Neoplasms - genetics - virology, Carcinoma, Hepatocellular - genetics - virology

Σύνδεσμος πρόσβασης: http://hub.hku.hk/bitstream/10722/135543/1/Content.pdf
https://pubmed.ncbi.nlm.nih.gov/21319996
http://hdl.handle.net/10722/135543

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Συγγραφείς: Carver, B, Haveman, WJ, Pandolfi, PP, Poliseno, L, Salmena, L, Zhang, J

Πηγή: Nature

Θεματικοί όροι: 0301 basic medicine, Messenger - Genetics, Binding, Competitive, Article, Cell Line, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Competitive, Genetic, Models, Ras Proteins - Genetics, Neoplasms, Proto-Oncogene Proteins, Humans, Genes, Tumor Suppressor, RNA, Messenger, 3' Untranslated Regions, 0303 health sciences, Models, Genetic, Neoplasms - Genetics, Pten Phosphohydrolase - Genetics, PTEN Phosphohydrolase, Binding, 3. Good health, Gene Expression Regulation, Neoplastic, Neoplastic - Genetics, Proto-Oncogene Proteins - Genetics, MicroRNAs, Gene Expression Regulation, Neoplastic - Genetics, Gene Expression Regulation, Genes, 3' Untranslated Regions - Genetics, ras Proteins, Rna, Pseudogenes - Genetics, Micrornas - Genetics, Rna, Messenger - Genetics, Tumor Suppressor, Pseudogenes

Σύνδεσμος πρόσβασης: https://europepmc.org/articles/pmc3206313?pdf=render
https://pubmed.ncbi.nlm.nih.gov/20577206
http://hdl.handle.net/10722/180739