Dynamic biomarkers in hormone receptor-positive/HER2-negative breast cancer trials: a new hope for precision oncology

Authors: Giuseppe Di Grazia, Rodrigo Sánchez-Bayona, Climent Casals-Pascual, Tomás Pascual, Daniele Generali, Alessandra Gennari, Paolo Vigneri, Nadia Harbeck, Javier Cortés, Aleix Prat, Francesco Schettini

Source: npj Breast Cancer, Vol 12, Iss 1 (2026)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/04f1ffeb2e60433285aa61fdde8a7215

Brain imaging screening in metastatic breast cancer: patients’ and physicians’ perspectives

Authors: Leonor Matos, Mette van Ramshorst, Volkmar Müller, Elisa Agostinetto, Sabine Linn, Matteo Lambertini, Veronique Dieras, Fanny le Du, Sofia Braga, Carmen Criscitiello, Katarzyna J. Jerzak, Gil Morgan, Sara Brucker, Patricia von Kroge, Renate Haidinger, Gema Rodríguez Recio, Eva Schumacher-Wulf, Mario Fontes Sousa, Francesco Schettini, Elena Laakmann

Source: Breast, Vol 84, Iss , Pp 104558- (2025)

Subject Terms: Brain metastasis, Metastatic breast cancer, Survey, Brain imaging, Screening, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977625005752; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/f6a22b2db44b426d92c5670b9b93d76c

Blood-based prognostic scores and early dynamics under immunotherapy to select patients with metastatic solid tumors for continuing immune check-point inhibition: a prospective longitudinal study

Authors: Javier García-Corbacho, Alberto Indacochea, Iván Victoria, Débora Moreno, Laura Angelats, Azucena E. González Navarro, Laura Mezquita, Fara Brasó-Maristany, Patricia Galván, Begoña Mellado, Nuria Viñolas, Tamara Sauri, Miquel Nogué, Barbara Adamo, Joan Maurel, Estela Pineda, Lydia Gaba, Oscar Reig, Neus Basté, Esther Sanfeliu, Manel Juan, Aleix Prat, Francesco Schettini

Source: Cancer Immunology, Immunotherapy, Vol 74, Iss 3, Pp 1-15 (2025)

Subject Terms: LIPI score, Immune check-point inhibitors, Immunotherapy, Metastatic, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-0851

Access URL: https://doaj.org/article/5afd366c60284440bebb0ea740ce5816

A population-based estimation of breast cancer recurrence in northeast Italy with administrative healthcare databases

Authors: Fabiola Giudici, Federica Toffolutti, Stefano Guzzinati, Francesco Schettini, Marina Bortul, Silvia Francisci, Manuel Zorzi, Sara De Vidi, Daniela Pierannunzio, Luigino Dal Maso

Source: Breast, Vol 82, Iss , Pp 104487- (2025)

Subject Terms: Breast cancer, Stage at diagnosis, Recurrence, Competing risk, Survival, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977625005041; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/ee406f4e1912435db46c9167a11d6335

A translational journey into resistance: decoding the role of NF1 in CDK4/6-inhibitor failure

Authors: Francesco Schettini, Milana Bergamino

Source: EBioMedicine, Vol 118, Iss , Pp 105860- (2025)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396425003044; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/58faf182ee844995968c918580af48ae

Clinical characteristics and prognostic factors in patients with breast cancer and leptomeningeal metastases from a large registry of BMBC

Authors: Elena Laakmann, Marcus Schmidt, Kristina Lübbe, Elisa Agostinetto, Mette van Ramshorst, Thomas Decker, Wolfram Malter, Francesco Schettini, Mario Fontes Sousa, Carsten Denkert, Tanja Neunhöffer, Leonor Matos, Sabine Linn, Marc Thill, Rudolf Weide, Amanda Fitzpatrick, Marta Vaz Batista, Christoph Mundhenke, Tjoung-Won Park-Simon, Fanny Le Du, Kerstin Riecke, Tanja Fehm, Isabel Witzel, Julia Rey, Valentina Nekljudova, Sibylle Loibl, Volkmar Müller

Source: Breast, Vol 81, Iss , Pp 104433- (2025)

Subject Terms: Leptomeningeal metastasis, Breast cancer, Registry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977625000529; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/5e15ea8872d844c48f9fc07dd70acb4e

Paclitaxel-related type I Kounis Syndrome in a very young patient with HER2-positive breast cancer and the role of genomics to disentangle a complex therapeutic scenario: a case report and narrative review

Authors: Javier Muñoz, Sabrina Nucera, Nuria Rubira Garcia, Isaac Cebrecos, Gabriela Oses, Sergi Ganau, Esther Sanfeliu, Pedro Jares, Mercedes Marín-Aguilera, Patricia Galván, Fara Brasó-Maristany, Olga Martínez-Sáez, Enric Cascos, Carme Font, Francesco Schettini

Source: Breast, Vol 81, Iss , Pp 104465- (2025)

Subject Terms: Kounis syndrome, HER2-Positive, Breast cancer, HER2DX, Genomics, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977625004825; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/62f067031f944c19a9f385cc5b8080d2

Comparative biological activity of palbociclib and ribociclib in hormone receptor-positive breast cancer

Authors: Natàlia Lorman-Carbó, Olga Martínez-Sáez, Aranzazu Fernandez-Martinez, Patricia Galván, Nuria Chic, Isabel Garcia-Fructuoso, Adela Rodríguez, Raquel Gómez-Bravo, Francesco Schettini, Paula Blasco, Oleguer Castillo, Blanca González-Farré, Barbara Adamo, Maria Vidal, Montserrat Muñoz, Charles M. Perou, Marcos Malumbres, Joaquín Gavilá, Tomás Pascual, Aleix Prat, Fara Brasó-Maristany

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ea86ec3e16194f1f8bdd3ad02a335dd9

Virtual Biomarkers and Simplified Metrics in the Modeling of Breast Cancer Neoadjuvant Therapy: A Proof-of-Concept Case Study Based on Diagnostic Imaging

Authors: Graziella Marino, Maria Valeria De Bonis, Marisabel Mecca, Marzia Sichetti, Aldo Cammarota, Manuela Botte, Giuseppina Dinardo, Maria Imma Lancellotti, Antonio Villonio, Antonella Prudente, Alexios Thodas, Emanuela Zifarone, Francesca Sanseverino, Pasqualina Modano, Francesco Schettini, Andrea Rocca, Daniele Generali, Gianpaolo Ruocco

Source: Medical Sciences, Vol 13, Iss 4, p 242 (2025)

Subject Terms: breast cancer, neoadjuvant therapy, biomarker, reactive–diffusive modeling, multidimensional modeling, diagnostic imaging, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3271/13/4/242; https://doaj.org/toc/2076-3271

Access URL: https://doaj.org/article/d02ba2f1b95d4bb8a852ed46a318f288

Central obesity, body mass index, metabolic syndrome and mortality in Mediterranean breast cancer patients

Authors: Anna Crispo, Livia S. A. Augustin, Assunta Luongo, Claudia Calderaio, Joao Breda, Sergio Coluccia, Alessandra Calabrese, Vittorio Marrazzo, Rosa Giannatiempo, Paola Trasacco, Elvira Palumbo, Sara Vitale, Giuseppe Porciello, Piergiacomo Di Gennaro, Roberta Caputo, Giuseppe Buono, Claudio Vernieri, Francesco Schettini, Maria Grimaldi, Flavia Nocerino, Egidio Celentano, Alfonso Amore, Mario Giuliano, Pietro De Placido, Carmine De Angelis, Roberto Bianco, Michelino De Laurentiis, Carlo La Vecchia, Grazia Arpino

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f3a2ca9b48954ebe9d773daeec362742

Prediction of response to neoadjuvant chemotherapy by MammaTyper® across breast cancer subtypes: A retrospective cross-sectional study

Authors: Francesco Schettini, Silvana Saracchini, Anna Bassini, Wally Marus, Serena Corsetti, Ilaria Specogna, Manuela Bertola, Elvia Micheli, Ralph M. Wirtz, Mark Laible, Uğur Şahin, Carla Strina, Manuela Milani, Sergio Aguggini, Richard Tancredi, Elena Fiorio, Sandro Sulfaro, Daniele Generali

Source: Breast, Vol 76, Iss , Pp 103753- (2024)

Subject Terms: MammaTyper, Hormone receptor, Breast cancer, Subtypes, pCR, Neoadjuvant, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977624000845; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/685e98291b35410783bf6f6dcacb65bd

Computational reactive–diffusive modeling for stratification and prognosis determination of patients with breast cancer receiving Olaparib

Authors: Francesco Schettini, Maria Valeria De Bonis, Carla Strina, Manuela Milani, Nicoletta Ziglioli, Sergio Aguggini, Ignazio Ciliberto, Carlo Azzini, Giuseppina Barbieri, Valeria Cervoni, Maria Rosa Cappelletti, Giuseppina Ferrero, Marco Ungari, Mariavittoria Locci, Ida Paris, Giovanni Scambia, Gianpaolo Ruocco, Daniele Generali

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/8ab5d27f2a0c432f915f67cda4c6e7d3

A 14-gene B-cell immune signature in early-stage triple-negative breast cancer (TNBC): a pooled analysis of seven studiesResearch in context

Authors: Benedetta Conte, Fara Brasó-Maristany, Adela Rodríguez Hernández, Tomás Pascual, Guillermo Villacampa, Francesco Schettini, Maria J. Vidal Losada, Elia Seguí, Laura Angelats, Isabel Garcia-Fructuoso, Raquel Gómez-Bravo, Natàlia Lorman-Carbó, Laia Paré, Mercedes Marín-Aguilera, Olga Martínez-Sáez, Barbara Adamo, Esther Sanfeliu, Beatrice Fratini, Claudette Falato, Núria Chic, Ana Vivancos, Patricia Villagrasa, Johan Staaf, Joel S. Parker, Charles M. Perou, Aleix Prat

Source: EBioMedicine, Vol 102, Iss , Pp 105043- (2024)

Subject Terms: Triple-negative breast cancer (TNBC), Pathological complete response (pCR), Event-free survival (EFS), Overall survival (OS), B-cell/immunoglobulin signature (IGG), Prognostic biomarkers, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424000781; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/e280cec22ed2498189d321ebd159a946

A perspective on the development and lack of interchangeability of the breast cancer intrinsic subtypes

Authors: Francesco Schettini, Fara Brasó-Maristany, Nicole M. Kuderer, Aleix Prat

Source: npj Breast Cancer, Vol 8, Iss 1, Pp 1-4 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/fc3a7992752645b0a4219b489965a012

Gene expression profiles of breast cancer metastasis according to organ site

Authors: Fara Brasó‐Maristany, Laia Paré, Nuria Chic, Olga Martínez‐Sáez, Tomás Pascual, Meritxell Mallafré‐Larrosa, Francesco Schettini, Blanca González‐Farré, Esther Sanfeliu, Débora Martínez, Patricia Galván, Esther Barnadas, Belinda Salinas, Pablo Tolosa, Eva Ciruelos, Esther Carcelero, Cecilia Guillén, Barbara Adamo, Reinaldo Moreno, Maria Vidal, Montserrat Muñoz, Aleix Prat

Source: Molecular Oncology, Vol 16, Iss 1, Pp 69-87 (2022)

Subject Terms: breast cancer, gene expression profiling, HER2‐low, metastatic sites, PAM50, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/ba667a7f8a964a6a8d8410bb45690ce0

Therapeutic resistance and optimal drug sequencing in HER2-positive metastatic breast cancer: unmet needs and future perspectives

Authors: Francesco Schettini, Fabiola Giudici, Daniele Generali

Source: Heliyon, Vol 10, Iss 1, Pp e23367- (2024)

Subject Terms: Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844023105755; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/85912a339b0a4254bffe9d44c44830ba

Evolving treatments and outcomes in HER2-Positive metastatic breast cancer: Data from the GIM14/BIOMETA study

Authors: Massimo Di Maio, Claudia Bighin, Francesco Schettini, Tommaso Ruelle, Laura Marandino, Alessandra Fabi, Carmine De Angelis, Mario Giuliano, Pietro De Placido, Michelino De Laurentiis, Ferdinando Riccardi, Caterina Picotto, Fabio Puglisi, Lucia Del Mastro, Grazia Arpino

Source: Breast, Vol 72, Iss , Pp 103583- (2023)

Subject Terms: Breast cancer, HER2-Positive, Metastasis, First line of therapy, Trastuzumab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977623005593; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/4d2b4ec77a90481d9884d1101fc4625e

Editorial: Diagnostic, prognostic and predictive factors of response in the era of precision oncology in breast cancer

Authors: Diletta Favero, Daniele Generali, Francesco Schettini

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: breast cancer, prognosis, prediction, biomarker, precision oncology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1337315/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/ae5d8a44a8a848f6b108ffcae617c8d9

Dissecting the biological heterogeneity of HER2-positive breast cancer

Authors: Francesco Schettini, Aleix Prat

Source: Breast, Vol 59, Iss , Pp 339-350 (2021)

Subject Terms: HER2, Breast cancer, Intrinsic subtypes, HER2-enriched, PAM50, TILs, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0960977621004276; https://doaj.org/toc/1532-3080

Access URL: https://doaj.org/article/9f67b1702c6e468196c6957b1e33737f

Circulating tumor DNA dynamics in advanced breast cancer treated with CDK4/6 inhibition and endocrine therapy

Authors: Olga Martínez-Sáez, Tomás Pascual, Fara Brasó-Maristany, Nuria Chic, Blanca González-Farré, Esther Sanfeliu, Adela Rodríguez, Débora Martínez, Patricia Galván, Anna Belén Rodríguez, Francesco Schettini, Benedetta Conte, Maria Vidal, Barbara Adamo, Antoni Martínez, Montserrat Muñoz, Reinaldo Moreno, Patricia Villagrasa, Fernando Salvador, Eva M. Ciruelos, Iris Faull, Justin I. Odegaard, Aleix Prat

Source: npj Breast Cancer, Vol 7, Iss 1, Pp 1-6 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2374-4677

Access URL: https://doaj.org/article/9539a7ac44b6431f941c92563bf19fa9