Deciphering letermovir's mode of action and resistance mutation effects.

Συγγραφείς: Gourin C; Université de Limoges, INSERM, RESINFIT, U1092, 2 rue du Dr Marcland, 87025, Limoges, France. Electronic address: claire.gourin@unilim.fr., Flores T; Univ Toulouse, INSERM, CNRS, Infinity - Toulouse Institute for Infections and Inflammatory Diseases,Toulouse, Hôpital Purpan-BP 3028, 1 place du Dr Baylac, 31024, Toulouse, France. Electronic address: thelma-nicole.flores-aguilar@inserm.fr., Lefèvre C; Université de Limoges, INSERM, RESINFIT, U1092, 2 rue du Dr Marcland, 87025, Limoges, France. Electronic address: camille.lefevre@etu.unilim.fr., Alain S; Université de Limoges, INSERM, RESINFIT, U1092, 2 rue du Dr Marcland, 87025, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Centre National de Référence pour les Herpèsvirus, 2 avenue Martin Luther King, 87042, Limoges, France. Electronic address: sophie.alain@unilim.fr., Ligat G; Univ Toulouse, INSERM, CNRS, Infinity - Toulouse Institute for Infections and Inflammatory Diseases,Toulouse, Hôpital Purpan-BP 3028, 1 place du Dr Baylac, 31024, Toulouse, France. Electronic address: gaetan.ligat@inserm.fr., Hantz S; Université de Limoges, INSERM, RESINFIT, U1092, 2 rue du Dr Marcland, 87025, Limoges, France; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, Centre National de Référence pour les Herpèsvirus, 2 avenue Martin Luther King, 87042, Limoges, France. Electronic address: sebastien.hantz@unilim.fr.

Πηγή: Antiviral research [Antiviral Res] 2025 Dec; Vol. 244, pp. 106289. Date of Electronic Publication: 2025 Oct 09.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Drug Resistance, Viral*/genetics , Antiviral Agents*/pharmacology , Cytomegalovirus*/drug effects , Cytomegalovirus*/genetics , Acetates*/pharmacology , Quinazolines*/pharmacology , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/chemistry, Humans ; HEK293 Cells ; Mutation ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Protein Binding ; Viral Structural Proteins

Multiple CRISPR zones-driven ultrasensitive detection of DNA via CRISPR-Cas12a and ligation-rolling circle amplification.

Συγγραφείς: Lin G; National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/ National Center of Gerontology, PR China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, PR China. Electronic address: gglin@nccl.org.cn., Li J; National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/ National Center of Gerontology, PR China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China., Zhang K; National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/ National Center of Gerontology, PR China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, PR China; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, Beijing, PR China.

Πηγή: Talanta [Talanta] 2025 Dec 01; Vol. 295, pp. 128336. Date of Electronic Publication: 2025 May 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

Ιατρικοί όροι (MeSH): CRISPR-Cas Systems*/genetics , DNA*/analysis , DNA*/genetics , Nucleic Acid Amplification Techniques*/methods , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/genetics , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/metabolism, Limit of Detection ; Humans ; Polymorphism, Single Nucleotide ; Bacterial Proteins

AND logic gate-based alternating PER-Cas12a signal amplification system for ultrasensitive detection of sEVs.

Συγγραφείς: Wang M; School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China., Zhang X; School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China., Fan J; School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China., Zhang C; School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China. Electronic address: clzhang@chem.ecnu.edu.cn., Xian Y; School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China. Electronic address: yzxian@chem.ecnu.edu.cn.

Πηγή: Talanta [Talanta] 2025 Dec 01; Vol. 295, pp. 128411. Date of Electronic Publication: 2025 May 27.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Breast Neoplasms*/diagnosis , Breast Neoplasms*/pathology , Extracellular Vesicles*/metabolism , Extracellular Vesicles*/chemistry , Biomarkers, Tumor* , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/genetics , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics , Nucleic Acid Amplification Techniques*/methods , Logic*, Humans ; Female ; Mucin-1/metabolism ; Mucin-1/genetics ; Limit of Detection ; Epithelial Cell Adhesion Molecule/metabolism ; Biosensing Techniques/methods ; CRISPR-Cas Systems ; Bacterial Proteins

A novel fluorescent sensing platform for miRNA-210 detection based on signal amplification via SDA and self-assembly Cas12a system via RCT.

Συγγραφείς: Shen C; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Chen X; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Yu Y; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Qin L; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Xu G; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China; Northern Jiangsu Institute of Clinical Medicine, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu, 223300, China., Wei F; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Yang J; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China., Hu Q; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China. Electronic address: huqin@njmu.edu.cn., Cen Y; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China; Clinical Medical Laboratory Center, Department of Neurology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, Jiangsu, 225300, China. Electronic address: yaocen@njmu.edu.cn.

Πηγή: Talanta [Talanta] 2025 Dec 01; Vol. 295, pp. 128382. Date of Electronic Publication: 2025 May 24.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

Ιατρικοί όροι (MeSH): MicroRNAs*/analysis , MicroRNAs*/genetics , Biosensing Techniques*/methods , Nucleic Acid Amplification Techniques*/methods , CRISPR-Cas Systems* , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/genetics , CRISPR-Associated Proteins*/chemistry , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics , Fluorescent Dyes*/chemistry, Humans ; Limit of Detection ; Spectrometry, Fluorescence ; Fluorescence ; Bacterial Proteins

A buffer-tuning strategy to profile domain-specific activity of chimeric I-TevI/CRISPR gene editors in vitro.

Συγγραφείς: Loedige KW; Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada., White AL; Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada., McMurrough TA; Specific Biologics Inc., Toronto, ON, M5G 0B7, Canada., Stead BE; Specific Biologics Inc., Toronto, ON, M5G 0B7, Canada., Edgell DR; Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada. dedgell@uwo.ca.

Πηγή: Scientific reports [Sci Rep] 2025 Nov 28; Vol. 15 (1), pp. 42742. Date of Electronic Publication: 2025 Nov 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Gene Editing*/methods , CRISPR-Cas Systems* , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics, Buffers ; RNA, Guide, CRISPR-Cas Systems/genetics ; Protein Domains ; DNA Cleavage ; Humans ; DNA/metabolism

Programmable no-nonspecific genetic analytical system via dual-circle-based rolling circle amplification with an efficient CRISPR/Cas12a biosensing strategy.

Συγγραφείς: Feng C; Department of Clinical Laboratory, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, 400037, China.; Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People's Republic of China, Chongqing, 400037, China., Wang Y; Department of Clinical Laboratory, Southwest Hospital, Army Medical University, Chongqing, 400038, China., Liu C; Department of Clinical Laboratory, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, 400037, China.; Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People's Republic of China, Chongqing, 400037, China., Dong F; Department of Clinical Laboratory, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, 400037, China.; Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People's Republic of China, Chongqing, 400037, China., Guo M; Department of Clinical Laboratory, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, 400037, China.; Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People's Republic of China, Chongqing, 400037, China., Liu F; Department of Clinical Laboratory, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, 400037, China. susufei@tmmu.edu.cn.; Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People's Republic of China, Chongqing, 400037, China. susufei@tmmu.edu.cn., Li Y; Analytical & Testing Center, Southwest University, Chongqing, 400715, China. yanli2112@swu.edu.cn., Zhang L; Department of Clinical Laboratory, The Second Affiliated Hospital (Xinqiao Hospital), Army Medical University, Chongqing, 400037, China. liqunzhang@tmmu.edu.cn.; Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center, Ministry of Education of the People's Republic of China, Chongqing, 400037, China. liqunzhang@tmmu.edu.cn.

Πηγή: Scientific reports [Sci Rep] 2025 Nov 19; Vol. 15 (1), pp. 40723. Date of Electronic Publication: 2025 Nov 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): CRISPR-Cas Systems*/genetics , Nucleic Acid Amplification Techniques*/methods , Biosensing Techniques*/methods , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics, Humans ; DNA, Single-Stranded/genetics ; DNA, Circular/genetics ; Limit of Detection ; Bacterial Proteins ; CRISPR-Associated Proteins

TdT/Cas12a cascade amplification biosensor for sensitive ALP activity detection.

Συγγραφείς: Pei C; Institute of Medical Sciences, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China. d202081630@alumni.hust.edu.cn., Yan B; Institute of Medical Sciences, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China. d202081630@alumni.hust.edu.cn., Wang Y; Gynecology Department, General Hospital of Ningxia Medical University, Yinchuan, 750004, China., Chen T; Institute of Medical Sciences, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China. d202081630@alumni.hust.edu.cn.; The Second Clinical Medical College of Ningxia Medical University, Yinchuan 75001, China., Du K; Institute of Medicine Nursing, Hubei University of Medicine, Shiyan, 442002, China., Ma L; Institute of Medical Sciences, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China. d202081630@alumni.hust.edu.cn., Wang J; Institute of Medical Sciences, General Hospital of Ningxia Medical University, Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan, 750004, China. d202081630@alumni.hust.edu.cn.

Πηγή: The Analyst [Analyst] 2025 Nov 17; Vol. 150 (23), pp. 5330-5337. Date of Electronic Publication: 2025 Nov 17.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 0372652 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-5528 (Electronic) Linking ISSN: 00032654 NLM ISO Abbreviation: Analyst Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Biosensing Techniques*/methods , Alkaline Phosphatase*/metabolism , Alkaline Phosphatase*/analysis , DNA Nucleotidylexotransferase*/metabolism , DNA Nucleotidylexotransferase*/chemistry , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/genetics, Humans ; HeLa Cells ; CRISPR-Cas Systems ; Limit of Detection

CRISPR/Cas12a-SERS biosensor based on sea urchin-like AuNPs for the detection of β-thalassemia mutant gene CD31.

Συγγραφείς: Xu H; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Chen H; Department of Clinical Laboratory, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, 545001, Guangxi, China., Li Y; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Wang Y; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Zeng H; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Xu Z; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Chen T; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Kong D; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Huang W; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Cheng H; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China., Zhou H; College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Jiang X; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China. xudong@gxust.edu.cn., Feng J; Guangxi Key Laboratory of Green Processing of Sugar Resources, Department of Medicine/College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou, 545005, Guangxi, China. hxpfengjun@gxust.edu.cn.

Πηγή: Mikrochimica acta [Mikrochim Acta] 2025 Nov 14; Vol. 192 (12), pp. 810. Date of Electronic Publication: 2025 Nov 14.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7808782 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-5073 (Electronic) Linking ISSN: 00263672 NLM ISO Abbreviation: Mikrochim Acta Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Biosensing Techniques*/methods , beta-Thalassemia*/genetics , beta-Thalassemia*/diagnosis , CRISPR-Cas Systems* , Spectrum Analysis, Raman*/methods , Gold*/chemistry , Metal Nanoparticles*/chemistry , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/metabolism , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/genetics, Animals ; Mutation ; Sea Urchins/chemistry ; Limit of Detection ; Humans ; DNA, Single-Stranded/chemistry ; DNA, Single-Stranded/genetics ; Sulfhydryl Compounds/chemistry ; Bacterial Proteins ; Benzoates

Cas12a-assisted split crRNA complex for analysis and detection of diverse entities.

Συγγραφείς: Xiao Y; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.; State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, China., Zhao R; State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, China., Bao Y; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.; State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, China., Lu B; State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, China., Jiang Y; Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China., Tang Y; State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, China., Li B; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.; State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun 130022, China.

Πηγή: Nucleic acids research [Nucleic Acids Res] 2025 Nov 13; Vol. 53 (21).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/genetics , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics , CRISPR-Cas Systems* , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , Biosensing Techniques*/methods, MicroRNAs/genetics ; MicroRNAs/analysis ; DNA, Single-Stranded/genetics ; DNA/genetics

Stable Converter-Powered Cascade Amplification of DNAzyme and Cas12a for Electrochemiluminescent Detection of DNA Adenine Methyltransferase.

Συγγραφείς: Wang Z; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China., Zhao ML; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China., Yan L; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China., Lei YM; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China., Liu J; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China., Zhuo Y; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.

Πηγή: Analytical chemistry [Anal Chem] 2025 Nov 04; Vol. 97 (43), pp. 24209-24216. Date of Electronic Publication: 2025 Oct 21.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): DNA, Catalytic*/metabolism , DNA, Catalytic*/chemistry , Electrochemical Techniques*/methods , Site-Specific DNA-Methyltransferase (Adenine-Specific)*/analysis , Site-Specific DNA-Methyltransferase (Adenine-Specific)*/metabolism , Biosensing Techniques*/methods , Luminescent Measurements*/methods , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/chemistry

Allosteric Activation of Cas12a via PAM Topological Engineering for Direct and Rapid Detection of Nucleases.

Συγγραφείς: Tao XL; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, 400715, China., Lei YM; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, 400715, China., Zhou XM; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, 400715, China., Chen ZP; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, 400715, China., Ma Y; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, 400715, China., Ma PY; College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun, 130012, China., Song DQ; College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Changchun, 130012, China., Zhuo Y; MOE Key Laboratory of Luminescence Analysis and Molecular Sensing, College of Chemistry and Chemical Engineering, Institute of Developmental Biology and Regenerative Medicine, Southwest University, Chongqing, 400715, China.

Πηγή: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2025 Nov 03; Vol. 64 (45), pp. e202515521. Date of Electronic Publication: 2025 Sep 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Ιατρικοί όροι (MeSH): CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/chemistry , DNA*/chemistry , DNA*/metabolism , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/chemistry, Allosteric Regulation ; CRISPR-Cas Systems ; Bacterial Proteins

A temperature-sensitive CRISPR-Cas12a system for sterile insect technique.

Συγγραφείς: Nguyen C; University of Texas Health Science Center, School of Public Health, Department of Epidemiology, Human Genetics, and Environmental Sciences, Center for Infectious Diseases, Houston, TX, 77030, USA., Omotayo AI; University of Texas Health Science Center, School of Public Health, Department of Epidemiology, Human Genetics, and Environmental Sciences, Center for Infectious Diseases, Houston, TX, 77030, USA., Sanz Juste S; Department of Epigenetics & Molecular Carcinogenesis at MD Anderson, The University of Texas MD Anderson Cancer Center, Houston, TX, 77054, USA.; Center for Cancer Epigenetics, MD Anderson Cancer Center, Houston, TX, 77054, USA., Feng X; Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, 310058, China. xfeng24@zju.edu.cn., López Del Amo V; University of Texas Health Science Center, School of Public Health, Department of Epidemiology, Human Genetics, and Environmental Sciences, Center for Infectious Diseases, Houston, TX, 77030, USA. victor.lopezdelamo@uth.tmc.edu.

Πηγή: Nature communications [Nat Commun] 2025 Nov 03; Vol. 16 (1), pp. 9677. Date of Electronic Publication: 2025 Nov 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): CRISPR-Cas Systems*/genetics , Infertility, Male*/genetics , CRISPR-Associated Proteins*/genetics , CRISPR-Associated Proteins*/metabolism , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/metabolism , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism, Animals ; Male ; Female ; Temperature ; RNA, Guide, CRISPR-Cas Systems/genetics ; Animals, Genetically Modified ; Gene Editing/methods

A Cas12a Toolbox for Rapid and Flexible Group B Streptococcus Genomic Editing and CRISPRi.

Συγγραφείς: Hillebrand GH; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Carlin SC; Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Giacobe EJ; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Stephenson HA; Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Collins J; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, USA., Hooven TA; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Pediatrics, Division of Newborn Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; RK Mellon Institute for Pediatric Research, Pittsburgh, Pennsylvania, USA.

Πηγή: Molecular microbiology [Mol Microbiol] 2025 Nov; Vol. 124 (5), pp. 449-461. Date of Electronic Publication: 2025 Sep 13.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Streptococcus agalactiae*/genetics , Gene Editing*/methods , CRISPR-Cas Systems*/genetics , Bacterial Proteins*/genetics , Bacterial Proteins*/metabolism , CRISPR-Associated Proteins*/genetics , CRISPR-Associated Proteins*/metabolism , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/metabolism, Plasmids/genetics ; Genome, Bacterial ; Mutagenesis ; Enterococcus faecium/genetics

Phage-encoded TelN inhibits bacterial Mre11-Rad50 nuclease to protect hairpin telomeres.

Συγγραφείς: Houmel M; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne, 1015, Lausanne, Switzerland., Pellaton N; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne, 1015, Lausanne, Switzerland., Anchimiuk A; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne, 1015, Lausanne, Switzerland., Gruber S; Department of Fundamental Microbiology (DMF), Faculty of Biology and Medicine (FBM), University of Lausanne, 1015, Lausanne, Switzerland. stephan.gruber@unil.ch.

Πηγή: The EMBO journal [EMBO J] 2025 Nov; Vol. 44 (22), pp. 6649-6674. Date of Electronic Publication: 2025 Oct 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Escherichia coli*/genetics , Escherichia coli*/virology , Escherichia coli*/metabolism , Telomere*/metabolism , Telomere*/genetics , Escherichia coli Proteins*/metabolism , Escherichia coli Proteins*/genetics , Escherichia coli Proteins*/antagonists & inhibitors , Viral Proteins*/metabolism , Viral Proteins*/genetics , Bacteriophages*/genetics , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics , Exodeoxyribonucleases*/metabolism , Exodeoxyribonucleases*/genetics

Multiscale identification of DNASE1L3 as a key target in MASLD progression to hepatocellular carcinoma.

Συγγραφείς: Xia L; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Yan X; Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. Electronic address: yxl9999@126.com., Zhang H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: zhanghuiman@126.com.

Πηγή: Pathology, research and practice [Pathol Res Pract] 2025 Nov; Vol. 275, pp. 156192. Date of Electronic Publication: 2025 Aug 31.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Carcinoma, Hepatocellular*/pathology , Carcinoma, Hepatocellular*/genetics , Carcinoma, Hepatocellular*/metabolism , Liver Neoplasms*/pathology , Liver Neoplasms*/genetics , Liver Neoplasms*/metabolism , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/metabolism , Fatty Liver*/pathology , Fatty Liver*/genetics, Humans ; Disease Progression ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor

Photocontrolled dissociation and toehold-mediated strand displacement-based synergistic regulation of CRISPR-Cas12a.

Συγγραφείς: Wu JN; School of Pharmacy, and Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Li C; School of Pharmacy, and Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Liu Z; School of Pharmacy, and Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Li X; School of Pharmacy, and Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Wang J; School of Pharmacy, and Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Lou X; State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China., Xia F; State Key Laboratory of Biogeology and Environmental Geology, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China., Dai J; School of Pharmacy, and Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Wu T; School of Pharmacy, and Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Πηγή: Nucleic acids research [Nucleic Acids Res] 2025 Oct 28; Vol. 53 (20).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Ιατρικοί όροι (MeSH): CRISPR-Cas Systems*/radiation effects , CRISPR-Cas Systems*/genetics , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/genetics , Gene Editing*/methods , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/genetics, Ultraviolet Rays ; DNA/chemistry ; DNA/genetics ; DNA/metabolism

Mechanism of trinucleotide repeat expansion by MutSβ-MutLγ and contraction by FAN1.

Συγγραφείς: Senoussi I; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland.; Department of Biology, Institute of Biochemistry, Eidgenössische Technische Hochschule (ETH), Zürich, Switzerland., Mengoli V; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Cerana A; Faculty of Biomedical Sciences, Institute of Oncology Research, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Rinaldi A; Faculty of Biomedical Sciences, Institute of Oncology Research, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Marco A; Data Curators B.V, DH, Oegstgeest, The Netherlands., Reginato G; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Moro SG; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Acharya A; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Roy M; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Jayachandran A; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Cannavo E; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Ceppi I; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland., Cejka P; Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana (USI), Bellinzona, Switzerland. petr.cejka@irb.usi.ch.

Πηγή: Nature communications [Nat Commun] 2025 Oct 27; Vol. 16 (1), pp. 9445. Date of Electronic Publication: 2025 Oct 27.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Trinucleotide Repeat Expansion*/genetics , Exodeoxyribonucleases*/metabolism , Exodeoxyribonucleases*/genetics , Multifunctional Enzymes*/metabolism , Multifunctional Enzymes*/genetics , MutL Proteins*/metabolism , MutL Proteins*/genetics , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/genetics, Humans ; MutS Homolog 3 Protein/metabolism ; MutS Homolog 3 Protein/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Proliferating Cell Nuclear Antigen/genetics ; MutL Protein Homolog 1/metabolism ; MutL Protein Homolog 1/genetics ; DNA/metabolism ; DNA/genetics ; DNA/chemistry ; MutS Homolog 2 Protein/metabolism ; MutS Homolog 2 Protein/genetics ; DNA Polymerase III/metabolism ; Huntington Disease/genetics

Functional and structural insights into HCMV terminase accessory proteins pUL77 and pUL93.

Συγγραφείς: Gourin C; Inserm, CHU Limoges, University of Limoges, RESINFIT, U1092, Limoges, France., Di Meo F; Inserm U1248 Pharmacology & Transplantation, Univ. Limoges, Limoges, France.; Inserm US042/CNRS UAR 2015 Integrative Biology Health Chemistry & Environment, Univ. Limoges, Limoges, France., Delmon C; Inserm, CHU Limoges, University of Limoges, RESINFIT, U1092, Limoges, France., Alain S; Inserm, CHU Limoges, University of Limoges, RESINFIT, U1092, Limoges, France.; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, National Reference Center for Herpesviruses (NRCHV), Limoges, France., Hantz S; Inserm, CHU Limoges, University of Limoges, RESINFIT, U1092, Limoges, France.; CHU Limoges, Laboratoire de Bactériologie-Virologie-Hygiène, National Reference Center for Herpesviruses (NRCHV), Limoges, France.

Πηγή: Journal of virology [J Virol] 2025 Oct 23; Vol. 99 (10), pp. e0117325. Date of Electronic Publication: 2025 Sep 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cytomegalovirus*/genetics , Cytomegalovirus*/drug effects , Cytomegalovirus*/enzymology , Viral Proteins*/genetics , Viral Proteins*/metabolism , Viral Proteins*/chemistry , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/chemistry, Humans ; Virus Replication/drug effects ; Antiviral Agents/pharmacology ; Cytomegalovirus Infections/virology ; Cytomegalovirus Infections/drug therapy ; Drug Resistance, Viral/genetics ; Quinazolines/pharmacology ; Acetates/pharmacology ; Mutation ; Nuclear Localization Signals/genetics ; Amino Acid Sequence

Engineered Cas12a-based one-tube detection of DNMT3A R882 H/C mutation in acute myeloid leukemia.

Συγγραφείς: Liu Y; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China., Liu Y; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China., Wu S; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China., Cao R; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China., Pan Y; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China; Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, China., Zhou F; Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China. Electronic address: zhoufuling@whu.edu.cn.

Πηγή: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Oct 15; Vol. 286, pp. 117609. Date of Electronic Publication: 2025 May 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Leukemia, Myeloid, Acute*/genetics , Leukemia, Myeloid, Acute*/diagnosis , DNA (Cytosine-5-)-Methyltransferases*/genetics , CRISPR-Cas Systems*/genetics , Biosensing Techniques*/methods , Endodeoxyribonucleases*/genetics , Endodeoxyribonucleases*/chemistry, DNA Methyltransferase 3A ; Humans ; Mutation ; Bacterial Proteins ; CRISPR-Associated Proteins

CRISPR-Programmed CuO Nanocatalyst Release for Ultrasensitive Detection of Pathogens in Sterile Body Fluids.

Συγγραφείς: Xiao J; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Hu X; Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China., Chen H; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Diao B; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Huang X; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China., Liu L; NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening & Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

Πηγή: Analytical chemistry [Anal Chem] 2025 Oct 14; Vol. 97 (40), pp. 22427-22435. Date of Electronic Publication: 2025 Oct 03.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Copper*/chemistry , CRISPR-Associated Proteins*/metabolism , CRISPR-Associated Proteins*/chemistry , Endodeoxyribonucleases*/metabolism , Endodeoxyribonucleases*/chemistry , Body Fluids*/microbiology , Metal Nanoparticles*/chemistry , CRISPR-Cas Systems*, Humans ; Catalysis ; Benzidines/chemistry ; Limit of Detection ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/analysis ; Bacterial Proteins/metabolism ; Bacterial Proteins/chemistry ; Colorimetry