Anti-VGLUT2 autoantibodies in neurological diseases

Συγγραφείς: Merle Corty, Friederike A. Arlt, Kathrin Borowski, Stephanie Wernick, Madeleine Scharf, Fabian A. Piecha, Claudia Steen, Philipp Oehler, Maria Buthut, Moritz Krill, Johann-Philipp Zöllner, Tammo Krafft, Robert Markewitz, Christiane Radzimski, Yvonne Denno, Christian Probst, Bianca Teegen, Christian Grefkes, Susanne Knake, Karsten Witt, Carsten Finke, Georg Hagemann, Jana Becker, Markus Kraemer, Torsten Witte, Lars Komorowski, Klaus-Peter Wandinger, Harald Prüss, Nico Melzer, Ramona Miske

Πηγή: Brain, behavior and immunity 129, 470-484 (2025). doi:10.1016/j.bbi.2025.06.014

Θεματικοί όροι: Autoantibodies: immunology, Male, Adult, Adolescent, Autoimmune Diseases: immunology, VGLUT2, Autoimmune Diseases, Nervous System Diseases: blood, Young Adult, Autoantibody, Biomarkers: blood, Autoimmune dementia, Polyneuropathy, Vesicular Glutamate Transport Protein 2: immunology, Humans, Encephalitis: immunology, Autoimmune encephalitis, Child, Autoantibodies, Aged, Retrospective Studies, Aged, 80 and over, Immunoglobulin G: blood, Autoantibodies: blood, Infant, Middle Aged, Nervous System Diseases: immunology, HEK293 Cells, Excitatory Amino Acid Transporter 2, Child, Preschool, Immunoglobulin G, Vesicular Glutamate Transport Protein 2, Female, Immunotherapy, Nervous System Diseases, Biomarkers

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40494504
https://pub.dzne.de/record/279430

Patient-derived monoclonal LGI1 autoantibodies elicit seizures, behavioral changes and brain MRI abnormalities in rodent models

Συγγραφείς: Manoj Upadhya, Alexander Stumpf, Jack O’Brien-Cairney, César Cordero Gómez, Jan Döring, Julius Hoffmann, Susanne Mueller, Yuko Fukata, Scott van Hoof, Divya Dhangar, Max A. Wilson, Arunvir Atwal, Richard Rosch, Gavin Woodhall, Philipp Boehm-Sturm, Masaki Fukata, Jakob Kreye, Dietmar Schmitz, Sukhvir K. Wright, Hans-Christian Kornau, Harald Prüss

Πηγή: Brain Behav Immun
Brain, behavior and immunity 126, 342-355 (2025). doi:10.1016/j.bbi.2025.02.019

Θεματικοί όροι: Autoantibodies: immunology, Male, Seizures: physiopathology, Hippocampus, Article, Antibodies, Monoclonal: immunology, Proteins: immunology, Mice, Seizures, Limbic Encephalitis, Seizures: immunology, Animals, Humans, Brain: immunology, Animal model, Autoantibodies, Behavior, Animal, Intracellular Signaling Peptides and Proteins, Antibodies, Monoclonal, Brain, Proteins, Human monoclonal antibody, Seizure, Magnetic Resonance Imaging, Rats, Mice, Inbred C57BL, Limbic Encephalitis: immunology, Brain: pathology, Disease Models, Animal, Behavior, Animal: drug effects, Intracellular Signaling Peptides and Proteins: immunology, LGI1, Female, Limbic encephalitis

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39984135
https://pub.dzne.de/record/277509

Brain atrophy patterns in anti-IgLON5 disease

Συγγραφείς: Yogeshwar, Selina M, Bartels, Frederik, Kraft, Andrea, Kovac, Stjepana, Wandinger, Klaus-Peter, de Vries, Juna M, Boon, Agnita J W, Veenbergen, Sharon, Geis, Christian, Penner, Loana, Melzer, Nico, Leypoldt, Frank, Grüter, Thomas, Blaabjerg, Morten, Pittock, Sean J, Gaig, Carles, Sabater, Lidia, Santamaria, Joan, Graus, Francesc, Dalmau, Josep, Prüss, Harald, Höftberger, Romana, Schreiner, Bettina, Muñiz-Castrillo, Sergio, McKeon, Andrew, Lewerenz, Jan, Irani, Sarosh, Mignot, Emmanuel, Titulaer, Maarten J, Ayzenberg, Ilya, Honnorat, Jérôme, Finke, Carsten, Consortium, IgLON5 Imaging, Picard, Géraldine, Crijnen, Yvette S, Bernard, Emilien, Heidbreder, Anna, Zekeridou, Anastasia, Ringelstein, Marius

Συνεισφορές: Wildemann, Brigitte, Kothaj, Jan, Ordas, Carlos, Álvarez, Javier Villacieros, Angstwurm, Klemens, Macher, Stefan, Berger-Sieczkowski, Evelyn, Tomás, Ángela Milán, Bastida, Antonio Martin, Quintas, Sonia, Tambasco, Nicola, Nigro, Pasquale, Iorio, Raffaele, Ono, Yoya, Shimohata, Takayoshi, Akio, Kimura, Akira, Takekoshi, Scheller-Nissen, Mette, Hartmann, Christian, Bastiaansen, Danielle, van Steenhoven, Robin, Schwichtenberg, Katia, Francillard, Aurélie Méneret Isabelle, Renard, Dimitri, Desestret, Virginie, Capet, Nicolas, Davion, Jeanbaptiste, Boucher, Julie, Zephir, Helene, Damier, Philippe, Combres, Helene, Rafiq, Marie, Bonneville, Fabrice, Cumin, Marina, Soulages, Antoine, Compoint, Mathilde, Moulin, Maximilien, Berling, Edouard, Garrigues, Eve, Chanson, Marine, Bourg, Veronique, Giordana, Caroline, Benoit, Jeanne, Flabeau, Olivier, Derivoyre, Emmanuelle, Ryckewaert, Gilles, Alberto, Tifanie, Carriere, Nicolas, Mostoufizadehs, Sohrab, Barbay, Melanie, Benaiteau, Marie, Vogrig, Alberto, Sellal, Francois, Casez, Olivier, Bruel, Cedric, Kalifa, L., Rusu, Elena Camelia, Demortiere, Sarah, Maarouf, Adil, Wang, Adrien, Brasset, Adelaide, Dalliere, Clarisse Carra, Attal, Arthur, Demourant, Céline, Cluse, Florent, Houeto, Jean-Luc, Brueggemann, Norbert, Dargvainiene, Justina, Seifert, Thomas, Oy, Ulrich Hofstadt-van, Nagel, Michael, Urbanek, Christian, Schroeder, Ina, Schramm, Peter, Tonner, Silke, Seitz, Caspar, Tschernatsch, Marlene, Chung, Ha-Yeun, Wickel, Jonathan, Schoeberl, Florian, Simabukuro, Mateus M, Zittel-Dirks, Simone

Πηγή: Brain 149(3), 884-896 (2026). doi:10.1093/brain/awaf256

Θεματικοί όροι: Male, Adult, Autoantibodies: immunology, Cell Adhesion Molecules, Neuronal, IgLON5, Autoimmune Diseases of the Nervous System: immunology, Encephalitis: diagnostic imaging, Cell Adhesion Molecules, Neuronal: immunology, atrophy, Autoimmune Diseases of the Nervous System: diagnostic imaging, Humans, Encephalitis: immunology, Atrophy: pathology, Brain: diagnostic imaging, Encephalitis: pathology, Aged, Autoantibodies, IgLON5 protein, human, Middle Aged, Magnetic Resonance Imaging, Autoimmune Diseases of the Nervous System: pathology, autoimmune encephalitis, Brain: pathology, Disease Progression, Female, MRI

Σύνδεσμος πρόσβασης: https://pub.dzne.de/record/285470

Serum and cerebrospinal kappa free light chains in psychiatric syndromes with neuronal and paraneoplastic autoantibodies

Συγγραφείς: Groeger, Luise M, Brinke, Kristina Auf dem, Wiltfang, Jens, Malchow, Berend, Fitzner, Dirk, Hansen, Niels, CAP, Simou, Amina, Luedecke, Daniel, Maier, Hannah B, Neyazi, Alexandra, Gallinat, Jürgen, Bleich, Stefan, Skripuletz, Thomas, Konen, Franz F

Πηγή: Behavioural brain research 496, 115858 (2026). doi:10.1016/j.bbr.2025.115858

Θεματικοί όροι: Male, Adult, Kappa free light chains, Mental Disorders: blood, Hashimoto Disease: cerebrospinal fluid, Mental Disorders: cerebrospinal fluid, Mental Disorders: diagnosis, Immunoglobulin kappa-Chains: blood, Hashimoto Disease: diagnosis, Encephalitis: cerebrospinal fluid, Encephalitis: diagnosis, Mental Disorders: immunology, Young Adult, Immunoglobulin kappa-Chains, Biomarkers: blood, Immunoglobulin kappa-Chains: cerebrospinal fluid, Hashimoto Disease: immunology, Humans, Encephalitis: immunology, Aged, Autoantibodies, Psychiatry, Autoantibodies: blood, Autoantibodies: cerebrospinal fluid, Middle Aged, Hashimoto Disease: blood, Biomarkers: cerebrospinal fluid, Female, Encephalitis: blood, Biomarkers

Σύνδεσμος πρόσβασης: https://pub.dzne.de/record/281861

Reduced Hospital Incidence of Autoimmune Encephalitis During the COVID-19 Pandemic

Συγγραφείς: Wickel, Jonathan, Chung, Ha-Yeun, Räuber, Saskia, Klausewitz, Jaqueline, Pfeffer, Lena K, Scherag, André, Menge, Til, Finke, Alexander, Doppler, Kathrin, Urbanek, Christian, Bien, Christian G, Seifert-Held, Thomas, Konen, Franz Felix, Hoffmann, Frank, Wandinger, Klaus-Peter, Tauber, Simone C, Süße, Marie, Lewerenz, Jan, Madlener, Marie, Rostasy, Kevin, Prüss, Harald, Sühs, Kurt-Wolfram, Kümpfel, Tania, Rössling, Rosa, Thaler, Franziska S, Leypoldt, Frank, Geis, Christian, group, GENERATE study, Bertolini, Annikki, Kraft, Andrea, Siebenbrodt, Kai, Bittner, Stefan, Juranek, Aleksandra, Brokbals, Mosche

Πηγή: Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology 13(3), e200555 (2026). doi:10.1212/NXI.0000000000200555

Θεματικοί όροι: Male, Adult, Aged, 80 and over, Autoantibodies: blood, Incidence, Middle Aged, Hospitalization: statistics & numerical data, Severity of Illness Index, Hashimoto Disease: epidemiology, COVID-19: epidemiology, Young Adult, Encephalitis: epidemiology, Hashimoto Disease: immunology, Humans, Germany: epidemiology, Female, Encephalitis: immunology, Retrospective Studies, Aged, Autoantibodies

Σύνδεσμος πρόσβασης: https://pub.dzne.de/record/285252

Clinical Characterization and Long-Term Outcome in Children and Adults With Anti-AMPA Receptor Encephalitis

Συγγραφείς: Chiara Milano, Ezgi Saylam, Claudia Papi, Laura Marmolejo, Alexandra Sankovic, Raphael Reinecke, Jeroen Kerstens, Chiara Pizzanelli, Mateus Mistieri Simabukuro, Marie Benaiteau, Bastien Joubert, Matteo Gastaldi, Lívia Almeida Dutra, Frank Leypoldt, Mareike Jansen, Izumi Kawachi, Hisanao Akiyama, Nikolas Boy, Silvia Bozzetti, Peter Broegger Christensen, Pietro Businaro, Alessandro Dinoto, Tal Friedman-Korn, Urara Fujiwara, Tatsuya Fukumoto, Kenshiro Fuse, Sam Ishmael Hooshmand, Lauren Hurst, Raffaele Iorio, Isabelle Korn-Lubetzki, André Filipe Lucchi Rodrigues, Sara Mariotto, Johannes Michael, Yuko Morimoto, Rinze Frederik Neuteboom, Amanda L. Piquet, Andrea O. Rossetti, Sabine Rumpler-Kreiner, Jonathan D. Santoro, Florian Schwendinger, Brenda Shen, Steffen Syrbe, Johannes Troger, Ingrid Wagner, Christian G. Bien, Eugenia Martinez-Hernandez, Thais Armangue, Romana Höftberger, Takahiro Iizuka, Maarten J. Titulaer, Jerome Honnorat, Francesc Graus, Josep O. Dalmau, Setty Magaña, Marianna Spatola

Πηγή: Neurol Neuroimmunol Neuroinflamm
Milano, C, Saylam, E, Papi, C, Marmolejo, L, Sankovic, A, Reinecke, R, Kerstens, J, Pizzanelli, C, Simabukuro, M M, Benaiteau, M, Joubert, B, Gastaldi, M, Dutra, L A, Leypoldt, F, Jansen, M, Kawachi, I, Akiyama, H, Boy, N, Bozzetti, S, Christensen, P B, Businaro, P, Dinoto, A, Friedman-Korn, T, Fujiwara, U, Fukumoto, T, Fuse, K, Hooshmand, S I, Hurst, L, Iorio, R, Korn-Lubetzki, I, Rodrigues, A F L, Mariotto, S, Michael, J, Morimoto, Y, Neuteboom, R F, Piquet, A L, Rossetti, A O, Rumpler-Kreiner, S, Santoro, J D, Schwendinger, F, Shen, B, Syrbe, S, Troger, J, Wagner, I, Bien, C G, Martinez-Hernandez, E, Armangue, T, Höftberger, R, Iizuka, T, Titulaer, M J, Honnorat, J, Graus, F, Dalmau, J O, Magaña, S & Spatola, M 2025, 'Clinical Characterization and Long-Term Outcome in Children and Adults With Anti-AMPA Receptor Encephalitis', Neurology® Neuroimmunology & Neuroinflammation, vol. 12, no. 5, e200453. https://doi.org/10.1212/NXI.0000000000200453
Neurology, vol. 12, no. 5, pp. e200453

Θεματικοί όροι: Male, Adult, Adolescent, Limbic Encephalitis/immunology, long-term follow-up, Receptors, AMPA/immunology, Encephalitis/immunology, Young Adult, SDG 3 - Good Health and Well-being, Limbic Encephalitis, Outcome Assessment, Health Care, Humans, Receptors, AMPA, Child, Retrospective Studies, Autoantibodies, Aged, Anti-AMPA Receptor, Middle Aged, Prognosis, Female, Child, Preschool, Autoantibodies/blood, Autoantibodies/immunology, Limbic Encephalitis/diagnosis, Encephalitis/diagnosis, Follow-Up Studies, outcome, Encephalitis, Research Article

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40680249
https://vbn.aau.dk/ws/files/810102988/Milano_et_al_2025_Clinical_Characterization_and_Long-Term_Outcome_in_Children_and_Adults_With_Anti-AMPA_Receptor_Encephalitis.pdf
https://www.scopus.com/pages/publications/105011201746
https://vbn.aau.dk/da/publications/8ff06fbc-7ae7-469b-aaf1-2d9cec0b9546
https://doi.org/10.1212/NXI.0000000000200453
https://pure.eur.nl/en/publications/2f48472f-4526-43f0-8225-8839bd10e2f5
https://doi.org/10.1212/NXI.0000000000200453
https://pub.uni-bielefeld.de/record/3005732
https://doi.org/10.1212/nxi.0000000000200453
https://serval.unil.ch/resource/serval:BIB_BBD82B6D1691.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_BBD82B6D16918
https://serval.unil.ch/notice/serval:BIB_BBD82B6D1691
https://hdl.handle.net/11562/1167968
https://doi.org/https://doi.org/10.1212/nxi.0000000000200453
https://doi.org/10.1212/NXI.0000000000200453

Neuron-reactive KIR+CD8+ T cells display an encephalitogenic transcriptional program in autoimmune encephalitis

Συγγραφείς: Perriot, Sylvain, Jones, Samuel, Genolet, Raphaël, Mathias, Amandine, Lindsay, Helen, Bobisse, Sara, Di Liberto, Giovanni, Canales, Mathieu, Queiroz, Lise, Sauvage, Christophe, Wagner, Ingrid, Oberholster, Larise, Gimenez, Marie, Bégarie, Diane, Kovac, Stjepana, Desestret, Virginie, Théaudin, Marie, Pot, Caroline, Wiendl, Heinz, Honnorat, Jérôme, Merkler, Doron, Gottardo, Raphaël, Harari, Alexandre Max-Albert, Du Pasquier, Renaud Alfred Robert

Πηγή: Nat Commun

Θεματικοί όροι: Male, Adult, Transcription, Genetic, Encephalitis / immunology, Induced Pluripotent Stem Cells, Hashimoto Disease, 616.07, Interferon-gamma / genetics, CD8-Positive T-Lymphocytes, Article, Hashimoto Disease / immunology, Ikaros Transcription Factor, Interferon-gamma, Receptors, KIR, Receptors, KIR / immunology, Humans, Hashimoto Disease / genetics, Aged, Receptors, KIR / metabolism, Neurons, Induced Pluripotent Stem Cells / immunology, Neurons / metabolism, CD8-Positive T-Lymphocytes / metabolism, Middle Aged, Receptors, KIR / genetics, Ikaros Transcription Factor / genetics, Neurons / immunology, Encephalitis / pathology, Interferon-gamma / metabolism, CD8-Positive T-Lymphocytes / immunology, Hashimoto Disease / pathology, Ikaros Transcription Factor / metabolism, Encephalitis, Female, Single-Cell Analysis, Encephalitis / genetics

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41022795
https://pmc.ncbi.nlm.nih.gov/articles/PMC12479921/
https://doi.org/10.1038/s41467-025-63573-1
https://pubmed.ncbi.nlm.nih.gov/41022795/

Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models

Συγγραφείς: van Hoof, Scott, Kreye, Jakob, Woodhall, Gavin L, Küpper, Maraike, Oder, Andreas, Kuchling, Joseph, Koch, Stefan Paul, Mueller, Susanne, Boehm-Sturm, Philipp, von Kries, Jens Peter, Finke, Carsten, Kirschstein, Timo, Cordero-Gómez, César, Wright, Sukhvir K, Prüss, Harald, Hoffmann, Julius, Reincke, Momsen, Sánchez-Sendin, Elisa, Duong, Sophie L, Upadhya, Manoj, Dhangar, Divya, Michór, Paulina

Πηγή: Brain Behav Immun
Brain, behavior and immunity 122, 266-278 (2024). doi:10.1016/j.bbi.2024.08.027

Θεματικοί όροι: Autoantibodies: immunology, Behavior, Animal: physiology, Mouse MRI, Male, CASPR2, Membrane Proteins: immunology, Magnetic Resonance Imaging: methods, Nerve Tissue Proteins, Hippocampus, Membrane Proteins: metabolism, Article, CNTNAP2 protein, human, Mice, Nerve Tissue Proteins: metabolism, Animals, Humans, Encephalitis: immunology, Autoimmune encephalitis, Autoantibodies: metabolism, Autoantibodies, Behavior, Animal, Antibodies, Monoclonal, Membrane Proteins, Brain, Human monoclonal antibody, Magnetic Resonance Imaging, Nerve Tissue Proteins: immunology, Rats, 3. Good health, Disease Models, Animal, Encephalitis, Encephalitis: metabolism, Female, Brain: metabolism, Hippocampus: metabolism

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39142424
https://pmc.ncbi.nlm.nih.gov/articles/PMC7618075/
https://pubmed.ncbi.nlm.nih.gov/39142424/
https://doi.org/10.1016/j.bbi.2024.08.027
https://pub.dzne.de/record/272149

Evolution from viral encephalitis to autoimmune encephalitis to multiple sclerosis: a case report

Συγγραφείς: Katharina Wurdack, Harald Prüss, Carsten Finke

Πηγή: J Neurol
Journal of neurology 271(10), 7035-7038 (2024). doi:10.1007/s00415-024-12659-9

Θεματικοί όροι: Adult, 0301 basic medicine, Encephalitis: drug therapy, Limbic Encephalitis: diagnostic imaging, Multiple Sclerosis, Neuroimmunology, Hashimoto Disease, Hashimoto Disease: diagnosis, Letter to the Editors, Multiple Sclerosis: diagnosis, Encephalitis: diagnostic imaging, Encephalitis: diagnosis, Multiple sclerosis, Overlap syndrome, 03 medical and health sciences, Limbic Encephalitis, Case report, Humans, Autoimmune encephalitis, Multiple Sclerosis: complications, Encephalitis, Varicella Zoster, Encephalitis, Varicella Zoster: drug therapy, 0303 health sciences, Multiple Sclerosis: drug therapy, Viral encephalitis, Magnetic Resonance Imaging, Encephalitis, Varicella Zoster: complications, Limbic Encephalitis: immunology, Limbic Encephalitis: drug therapy, Disease Progression, Encephalitis, Female, Hashimoto Disease: drug therapy

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39217218
https://pub.dzne.de/record/272582

Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens

Συγγραφείς: Di Liberto, Giovanni, Egervari, Kristof Levente, Vogrig, Alberto, Spatola, Marianna, Piccinno, Margot, Vincenti, Ilena, Wagner, Ingrid, Kreutzfeldt, Mario, Endmayr, Verena, Ostertag, Karoline, Rahimi, Jasmin, Vicino, Alex, Pröbstel, Anne-Katrin, Meyronet, David, Frank, Stephan, Prinz, Marco, Hewer, Ekkehard, Brouland, Jean-Philippe, de Leval, Laurence, Parkkinen, Laura, Draganski, Bogdan, Desestret, Virginie, Dubey, Divyanshu, Pittock, Sean J, Roemer, Shanu F, Dickson, Dennis W, Höftberger, Romana, Irani, Sarosh R, Honnorat, Jérôme, Du Pasquier, Renaud, Merkler, Doron

Πηγή: Acta Neuropathol
Acta neuropathologica 149(1), 35 (2025). doi:10.1007/s00401-025-02882-7
Acta neuropathologica, vol. 149, no. 1, pp. 35

Θεματικοί όροι: Male, Synapses: immunology, CD8-Positive T-Lymphocytes, Autoantigens, Neurons: immunology, Neurons / pathology, Neuroinflammation, Hashimoto Disease: immunology, Brain: immunology, Encephalitis / metabolism, Humans, Encephalitis/pathology, Encephalitis/immunology, Encephalitis/metabolism, Female, Middle Aged, Neurons/pathology, Neurons/immunology, Neurons/metabolism, Hashimoto Disease/pathology, Hashimoto Disease/immunology, Adult, STAT1 Transcription Factor/metabolism, Synapses/pathology, Synapses/immunology, Synapses/metabolism, Aged, Autoantigens/immunology, Brain/pathology, Brain/immunology, CD8-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/pathology, Young Adult, Neurodegeneration, Phagocytes, Resident memory T cells, Synapses, Neurons, Neurons / metabolism, Brain / immunology, Brain / pathology, Autoantigens: immunology, Brain, CD8-Positive T-Lymphocytes: pathology, Synapses: pathology, CD8-Positive T-Lymphocytes / immunology, STAT1 Transcription Factor, Hashimoto Disease / pathology, STAT1 Transcription Factor / metabolism, Encephalitis, Encephalitis: metabolism, Neurons: metabolism, Encephalitis / immunology, Hashimoto Disease, 616.07, Autoantigens / immunology, Hashimoto Disease / immunology, Synapses: metabolism, STAT1 Transcription Factor: metabolism, Synapses / immunology, Encephalitis: immunology, Encephalitis: pathology, Hashimoto Disease: pathology, Original Paper, Synapses / pathology, CD8-Positive T-Lymphocytes: immunology, Neurons / immunology, Synapses / metabolism, Encephalitis / pathology, Brain: pathology, Neurons: pathology, CD8-Positive T-Lymphocytes / pathology

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40278930
https://pub.dzne.de/record/278073
https://serval.unil.ch/resource/serval:BIB_2BE75AE22CA6.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_2BE75AE22CA6
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_2BE75AE22CA66

Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes

Συγγραφείς: Stephan Krohn, Leonie Müller-Jensen, Joseph Kuchling, Amy Romanello, Katharina Wurdack, Sophia Rekers, Thorsten Bartsch, Frank Leypoldt, Friedemann Paul, Christoph J. Ploner, Harald Prüss, Carsten Finke

Πηγή: Neurol Neuroimmunol Neuroinflamm
Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology 12(2), e200360 (2025). doi:10.1212/NXI.0000000000200360

Θεματικοί όροι: Male, Immunotherapy: methods, Nerve Net: physiopathology, Neuropsychological Tests, LGI1 protein, human, Encephalitis: diagnostic imaging, Cognitive Dysfunction: physiopathology, White Matter: diagnostic imaging, Cognitive Dysfunction: etiology, Prospective Studies, Nerve Net: immunology, Nerve Net: pathology, Autoantibodies: blood, Cognitive Dysfunction: diagnosis, Intracellular Signaling Peptides and Proteins, Neuroimaging: methods, Cognitive Dysfunction: immunology, Cognitive Dysfunction: diagnostic imaging, Middle Aged, White Matter, Limbic Encephalitis: therapy, Diffusion Tensor Imaging, Nerve Net: diagnostic imaging, Autoimmune Diseases: diagnosis, Limbic Encephalitis: complications, anti-leucine-rich glioma-inactivated 1 autoantibody, Female, Immunotherapy, Function and Dysfunction of the Nervous System, Autoimmune Diseases: therapy, Research Article, Autoantibodies: immunology, Autoimmune Diseases: immunology, Neuroimaging, Autoimmune Diseases, Limbic Encephalitis, Cognitive Dysfunction: pathology, Connectome, Humans, Cognitive Dysfunction, Encephalitis: immunology, White Matter: immunology, Autoimmune Diseases: complications, Limbic Encephalitis: diagnosis, Autoantibodies, Aged, Topic 3: Integrative Biomedicine, Limbic Encephalitis: immunology, Cross-Sectional Studies, White Matter: pathology, Cognitive Dysfunction: prevention & control, Nerve Net, Follow-Up Studies

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39879565
https://edoc.mdc-berlin.de/id/eprint/25102/1/25102oa.pdf
https://doi.org/10.1212/nxi.0000000000200360
https://edoc.mdc-berlin.de/id/eprint/25102/2/25102suppl.pdf
https://pub.dzne.de/record/276321

Case Report: Acute polymorphic psychosis and NMDA-R IgG antibodies in serum: a follow-up case study

Συγγραφείς: von Zedtwitz, Katharina, Weiser, Judith, Tebartz van Elst, Ludger, Hannibal, Luciana, Prüss, Harald, Rau, Alexander, Endres, Dominique, Dressle, Raphael J, Maier, Simon J, Feige, Bernd, Nickel, Kathrin, Venhoff, Nils, Domschke, Katharina, Brumberg, Joachim, Rauer, Sebastian

Πηγή: Front Immunol
Frontiers in immunology 16, 1630357 (2025). doi:10.3389/fimmu.2025.1630357

Θεματικοί όροι: Autoantibodies: immunology, COVID-19: immunology, brain, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: immunology, Immunology, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: blood, Receptors, N-Methyl-D-Aspartate, Psychotic Disorders: immunology, Psychotic Disorders: diagnosis, Psychotic Disorders: blood, Humans, Autoantibodies, Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Immunoglobulin G: blood, Autoantibodies: blood, COVID-19: complications, COVID-19, Psychotic Disorders: etiology, autoimmune, Magnetic Resonance Imaging, autoimmune encephalitis, Immunoglobulin G: immunology, Psychotic Disorders, inflammation, Immunoglobulin G, Positron-Emission Tomography, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: diagnosis, Receptors, N-Methyl-D-Aspartate: immunology, immunotherapy, Follow-Up Studies

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40927716
https://pmc.ncbi.nlm.nih.gov/articles/PMC12414783/
https://pubmed.ncbi.nlm.nih.gov/40927716/
https://doi.org/10.3389/fimmu.2025.1630357
https://pub.dzne.de/record/281364

NMDA receptor autoantibodies primarily impair the extrasynaptic compartment

Συγγραφείς: Zoe Jamet, Camille Mergaux, Morgane Meras, Delphine Bouchet, Frédéric Villega, Jakob Kreye, Harald Prüss, Laurent Groc

Πηγή: Brain
Brain 147(8), 2745-2760 (2024). doi:10.1093/brain/awae163

Θεματικοί όροι: Autoantibodies: immunology, Neurons: metabolism, Receptor, EphB2: metabolism, Receptor, EphB2, encephalitis, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: immunology, Autoantibodies: pharmacology, interactome, membrane proteins, Receptors, N-Methyl-D-Aspartate, Hippocampus, Mice, Synapses: metabolism, Animals, Humans, Receptors, N-Methyl-D-Aspartate: metabolism, Cells, Cultured, Autoantibodies, Neurons, Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Rats, Synapses, Receptors, N-Methyl-D-Aspartate: immunology, Original Article, Hippocampus: metabolism, extrasynaptic NMDA receptor, autoantibody

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38758090
https://pub.dzne.de/record/271072

NORSE seasonality may vary geographically in adults

Συγγραφείς: Andrea Enerstad Bolle, Thomas Gaist, Anna Maria Eleonora Kuljis, Morten Blaabjerg, Christoph Patrick Beier

Πηγή: Epilepsia Open
Epilepsia Open, Vol 9, Iss 3, Pp 1088-1095 (2024)
Bolle, A E, Gaist, T, Kuljis, A M E, Blaabjerg, M & Beier, C P 2024, 'NORSE seasonality may vary geographically in adults', Epilepsia Open, vol. 9, no. 3, pp. 1088-1095. https://doi.org/10.1002/epi4.12944

Θεματικοί όροι: Adult, Male, Drug Resistant Epilepsy, Adolescent, NORSE, Denmark, Hashimoto Disease, Encephalitis/immunology, Cohort Studies, Young Adult, Status Epilepticus, Drug Resistant Epilepsy/immunology, Humans, RC346-429, Aged, Autoantibodies, Retrospective Studies, Aged, 80 and over, status epilepticus, seasonality, Middle Aged, Status Epilepticus/immunology, Denmark/epidemiology, autoimmune encephalitis, Short Research Articles, 3. Good health, inflammation, Hashimoto Disease/immunology, Encephalitis, Female, Neurology. Diseases of the nervous system, Seasons, Autoantibodies/blood

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/38635008
https://doaj.org/article/4b54f1fab70241d6a1903ffaa5e1318f
https://findresearcher.sdu.dk/ws/files/263881388/Epilepsia_Open_-_2024_-_Bolle_-_NORSE_seasonality_may_vary_geographically_in_adults.pdf
https://doi.org/10.1002/epi4.12944
https://portal.findresearcher.sdu.dk/da/publications/c0f3082a-3b82-4e75-b054-93625797f3d6

Intravenous immunoglobulin as first-line acute treatment in adults with autoimmune encephalitis caused by antibodies to NMDAR, LGI1 and CASPR2

Συγγραφείς: Rittel, Joyce Christin, Hudasch, Dominica, Friese, Manuel A, Malter, Michael, Madlener, Marie, Kraft, Andrea, Hoffmann, Frank, Lewerenz, Jan, Senel, Makbule, Wickel, Jonathan, Geis, Christian, Moser, Andreas, Doppler, Kathrin, Wandinger, Klaus-Peter, Bartsch, Thorsten, Leypoldt, Frank, Thaler, Franziska, Kümpfel, Tania, Meuth, Sven, Melzer, Nico, Finke, Carsten, Prüss, Harald, Stangel, Martin, Bergh, Florian Then, Sühs, Kurt-Wolfram, Encephalitis, German Network for Research on Autoimmune, Lesser, Martin, Aktas, Orhan, Nagel, Michael, Huttner, Hagen B, Rostasy, Kevin, Tauber, Simone

Πηγή: Journal of neurology 272(4), 287 (2025). doi:10.1007/s00415-025-13032-0

Θεματικοί όροι: Male, Immunologic Factors: therapeutic use, Encephalitis: drug therapy, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: immunology, LGI1 protein, human, Autoimmune Diseases of the Nervous System: immunology, CNTNAP2 protein, human, Hashimoto Disease: therapy, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: therapy, Hashimoto Disease: immunology, LGI-1, Autoimmune encephalitis, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: drug therapy, Immunoglobulins, Intravenous: therapeutic use, Receptors, N-Methyl-D-Aspartate: antagonists & inhibitors, Immunoglobulins, Intravenous: pharmacology, Autoantibodies: blood, Immunologic Factors: administration & dosage, Intracellular Signaling Peptides and Proteins, Immunoglobulins, Intravenous, Middle Aged, Autoimmune Diseases of the Nervous System: therapy, Nerve Tissue Proteins: immunology, Treatment Outcome, Intracellular Signaling Peptides and Proteins: immunology, Encephalitis: therapy, Female, Immunotherapy, Adult, Autoantibodies: immunology, CASPR2, Membrane Proteins: immunology, Nerve Tissue Proteins, Immunoglobulins, Intravenous: administration & dosage, Receptors, N-Methyl-D-Aspartate, Proteins: immunology, Young Adult, Humans, Immunologic Factors, Encephalitis: immunology, Autoimmune Diseases of the Nervous System: drug therapy, Aged, Retrospective Studies, Autoantibodies, IVIG, Membrane Proteins, NMDA, Receptors, N-Methyl-D-Aspartate: immunology, Hashimoto Disease: drug therapy

Σύνδεσμος πρόσβασης: https://pub.dzne.de/record/277746

Risk of Epilepsy and Factors Associated With Time to Seizure Remission in Anti-LGI1 Encephalitis: Long-Term Outcome in 236 Patients

Συγγραφείς: Baumgartner, Tobias, Freyberg, Moritz, Kovac, Stjepana, Strippel, Christine, Thaler, Franziska S, Eisenhut, Katharina, Lewerenz, Jan, Becker, Felicitas, Reinecke, Raphael, Malter, Michael Peter, Sühs, Kurt-Wolfram, Tauber, Simone C, Campetella, Lucia, Von Podewils, Felix, Melzer, Nico, Wandinger, Klaus-Peter, Fernandez Ceballos, Romina-Anna-Maria, Kuhle, Jens, Berger, Klaus, Bauer, Tobias, Rüber, Theodor, Racz, Attila, Becker, Albert J, Crijnen, Yvette, Pitsch, Julika, Kuhlenbäumer, Gregor, Muñiz-Castrillo, Sergio, Honnorat, Jerome, Titulaer, Maarten J, Leypoldt, Frank, Surges, Rainer, group, and the GENERATE study, Dargvainiene, Justina, Behning, Charlotte, Bien, Christian G, Rada, Anna, Prüss, Harald, Rössling, Rosa

Πηγή: Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology 12(6), e200469 (2025). doi:10.1212/NXI.0000000000200469

Θεματικοί όροι: Male, Adult, LGI1 protein, human, Autoimmune Diseases of the Nervous System: immunology, Autoimmune Diseases of the Nervous System: complications, Young Adult, Epilepsy: epidemiology, Humans, Encephalitis: immunology, Retrospective Studies, Aged, Autoantibodies, Autoantibodies: blood, Intracellular Signaling Peptides and Proteins, Seizures: etiology, Epilepsy: etiology, Middle Aged, Autoimmune Diseases of the Nervous System: therapy, Limbic Encephalitis: immunology, Limbic Encephalitis: complications, Intracellular Signaling Peptides and Proteins: immunology, anti-leucine-rich glioma-inactivated 1 autoantibody, Female, Encephalitis: complications, Follow-Up Studies

Σύνδεσμος πρόσβασης: https://pub.dzne.de/record/283118

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis

Συγγραφείς: Shammas, Ghazal, Piccinno, Margot, Egervari, Kristof Levente, Lemeille, Sylvain, Mariotte, Alexandre, Maltese, Federica, Panzeri, Alessandra, Wagner, Ingrid, Fonta, Nicolas, Furlan, Tiphaine, Kreutzfeldt, Mario, Vincenti, Ilena, Yermanos, Alexander, Page, Nicolas, Bellone, Camilla, Picon Munoz, Carmen, Di Liberto, Giovanni, Merkler, Doron

Πηγή: Neuron. 114:622-639.e11

Θεματικοί όροι: 616.8, Cytotoxic T cell, encephalitis, Encephalitis / immunology, Mice, Transgenic, 616.07, Epigenesis, Genetic, chromatin remodeling, Chromatin remodeling, Mice, Neurons / pathology, Non-cytolytic viral clearance, Animals, Humans, Encephalitis / metabolism, Multi-omics, Synapses / pathology, Neurons / metabolism, Neuron, multi-omics, Neurons / immunology, Synapses / metabolism, neuron, Interferon-gamma / metabolism, Encephalitis / pathology, T-Lymphocytes, Cytotoxic / immunology, Mice, Inbred C57BL, Disease Models, Animal, Synaptic loss, synaptic loss, transcriptional adaptation, Encephalitis, non-cytolytic viral clearance, Encephalitis / genetics, Transcriptional adaptation, cytotoxic T cell

Περιγραφή αρχείου: application/pdf

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/41448185
https://hdl.handle.net/20.500.14243/564352
https://doi.org/10.1016/j.neuron.2025.11.006

Anti-septin complex positive autoimmune encephalitis after severe falciparum malaria: a case report

Συγγραφείς: Kalbitz, Sven, Arlt, Friederike A, Wolf, Johannes, Corty, Merle, Prüss, Harald, Lübbert, Christoph

Πηγή: Malar J
Malaria Journal, Vol 23, Iss 1, Pp 1-7 (2024)
Malaria journal 23(1), 369 (2024). doi:10.1186/s12936-024-05207-3

Θεματικοί όροι: Male, 0301 basic medicine, Encephalitis: drug therapy, RC955-962, Autoimmunity, Case Report, Infectious and parasitic diseases, RC109-216, Hashimoto Disease, Hashimoto Disease: diagnosis, Malaria, Falciparum: immunology, Encephalitis: diagnosis, Hashimoto Disease: complications, 03 medical and health sciences, Arctic medicine. Tropical medicine, Case report, Humans, Malaria, Falciparum: drug therapy, Encephalitis: immunology, Autoimmune encephalitis, Falciparum malaria, Malaria, Falciparum, Cerebral malaria, Post malaria neurologic syndrome (PMNS), Autoantibodies, 0303 health sciences, Autoantibodies: blood, Malaria, Falciparum: complications, Malaria, Falciparum: diagnosis, Middle Aged, Septin complex, Encephalitis: parasitology, Encephalitis, Hashimoto Disease: drug therapy, Anti-septin antibodies

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39663534
https://doaj.org/article/f08d6cbc23354d3f9c1b1cb87a08ac5e
https://pub.dzne.de/record/273936

Neuron-reactive KIR + CD8 + T cells display an encephalitogenic transcriptional program in autoimmune encephalitis

Συγγραφείς: Perriot, Sylvain, Jones, Samuel, Genolet, Raphaël, Mathias, Amandine, Lindsay, Helen, Bobisse, Sara, Di Liberto, Giovanni, Canales, Mathieu, Queiroz, Lise, Sauvage, Christophe, Wagner, Ingrid, Oberholster, Larise, Gimenez, Marie, Bégarie, Diane, Kovac, Stjepana, Desestret, Virginie, Théaudin, Marie, Pot, Caroline, Wiendl, Heinz, Honnorat, Jérôme, Merkler, Doron, Gottardo, Raphaël, Harari, Alexandre Max-Albert, Du Pasquier, Renaud Alfred Robert

Πηγή: ISSN: 2041-1723 ; Nature communications, vol. 16, no. 1 (2025) 8568.

Θεματικοί όροι: info:eu-repo/classification/ddc/616.07, Humans, CD8-Positive T-Lymphocytes / immunology, CD8-Positive T-Lymphocytes / metabolism, Neurons / immunology, Neurons / metabolism, Encephalitis / immunology, Encephalitis / genetics, Encephalitis / pathology, Receptors, KIR / metabolism, KIR / immunology, KIR / genetics, Hashimoto Disease / immunology, Hashimoto Disease / genetics, Hashimoto Disease / pathology, Female, Male, Ikaros Transcription Factor / genetics, Ikaros Transcription Factor / metabolism, Middle Aged, Induced Pluripotent Stem Cells / immunology, Adult, Single-Cell Analysis, Interferon-gamma / genetics, Interferon-gamma / metabolism, Aged, Transcription, Genetic

Relation: info:eu-repo/semantics/altIdentifier/pmid/41022795; info:eu-repo/grantAgreement/EC/H2020/865026/EU/Molecular pathology of anti-viral T cell responses in the central nervous system/PATHOCODE; unige:190071

Διαθεσιμότητα: https://archive-ouverte.unige.ch/unige:190071

Specific viral antibodies associate with anti-NMDAR encephalitis after herpes simplex encephalitis

Συγγραφείς: Jakob Kreye, William R. Morgenlander, Manjusha Thakar, Poul M. Schulte-Frankenfeld, Sarah Schott, Isabel Bünger, Hans-Christian Kornau, Julia W. Angkeow, Sahana Jayaraman, Carolin Otto, Wiebke Hahn, Jan Lewerenz, Franziska S. Thaler, Mirjam Korporal-Kuhnke, Nico Melzer, Justina Dargvainiene, Christian G. Bien, Rose Kohlie, Erik Lattwein, Dietmar Schmitz, Peter A. Calabresi, Carlos A. Pardo, Harald Prüss, Klemens Ruprecht, H. Benjamin Larman

Πηγή: Brain, behavior and immunity 130, 106073 (2025). doi:10.1016/j.bbi.2025.106073

Θεματικοί όροι: Male, Adult, Antibodies, Viral: immunology, Herpesvirus 2, Human, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: immunology, Encephalitis, Herpes Simplex: immunology, Antibodies, Viral: blood, Herpesvirus 1, Human, Antibodies, Viral, Antibody reactome, Receptors, N-Methyl-D-Aspartate, Young Adult, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: virology, Herpesvirus 1, Human: immunology, Biomarkers: blood, HSE, Herpesvirus 2, Human: immunology, Humans, PhIP-Seq, Anti-N-Methyl-D-Aspartate Receptor Encephalitis: etiology, Autoantibodies, Encephalitis, Herpes Simplex: complications, Anti-N-Methyl-D-Aspartate Receptor Encephalitis, MICAR, HSV, Middle Aged, Intrathecal synthesis, NMDAR, Antibodies, Viral: cerebrospinal fluid, Encephalitis, Receptors, N-Methyl-D-Aspartate: immunology, Female, Encephalitis, Herpes Simplex, Biomarkers

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40803454
https://pub.dzne.de/record/280960