Substrate Specificity and Kinetic Mechanism of the NAD+‑Dependent Deacylase from Mycobacterium tuberculosis, Rv1151c (Mt-Sirt)

Συγγραφείς: Mellott, Drake M., Zhu, Jiyun, Fulcher, Hudson, Meek, Thomas D.

Πηγή: Biochemistry. 65(15):2400-2418

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acs.biochem.6c00374

Pseudomonas Virulence Factor Produces Autoinducer (S)‑Valdiazen

Συγγραφείς: Crawford, Drake M.^aff1, Roche, Jack C.^aff1, Guo, Qiang^{aff1, aff2}, Brache, Christopher^aff1, Li, Bo^aff1

Πηγή: ACS Chemical Biology. 20(5):1029-1037

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acschembio.4c00837

Record Low Loss 0.144 dB/km 2-Core Optical Fiber for Submarine Transmission

Συγγραφείς: Tandon, P., Bennett, K., Tuggle, M., Butler, D., de Pedro, H., Hebgen, P., Sutton, C., Matthews, H.B., Drake, M., Johnson, S., Makovejs, S., Downie, J., Galdino, L.

Πηγή: Journal of Lightwave Technology J. Lightwave Technol. Lightwave Technology, Journal of. 42(12):4213-4221 Jun, 2024

Challenges to overcome in a randomised trial for Proper Understanding of Recurrent Stress Urinary Incontinence Treatment in women: the PURSUIT RCT

Συγγραφείς: Pope, C., Cochrane, M., Clement, C., Liu, Y., Paramasivan, S., Noble, S., MacNeill, S.J., Lewis, A.L., Taylor, J., Fitzgerald, B., Cotterill, N., Greenwell, T., Hashim, H., Jha, S., Thiruchelvam, N., Toozs-Hobson, P., White, A., Agur, W., Lane, J.A., Drake, M.

Πηγή: Health Technol Assess
Health Technology Assessment (2025)

Θεματικοί όροι: Urologic Diseases, Comparative Effectiveness Research, Clinical Trials and Supportive Activities, Renal and urogenital, residual volume, Clinical Research, Health Services and Systems, Health Sciences, Behavioral and Social Science, middle aged, Medical technology, Minority Health, R855-855.5, humans, urinary incontinence, Prevention, adult, quality-adjusted life-years, Health Services, stress urinary incontinence, prolapse, Good Health and Well Being, female, Cost Effectiveness Research, surveys and questionnaires, Public Health, Patient Safety, randomised controlled trial, Research Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40613491
https://pubmed.ncbi.nlm.nih.gov/40613491/
https://doi.org/10.3310/AKAK8992
https://pmc.ncbi.nlm.nih.gov/articles/PMC12376003/
https://doaj.org/article/e033f382c70a4c93b401b9b8c7020b8e
https://eprints.whiterose.ac.uk/id/eprint/229565/

Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation

Συγγραφείς: Abdel-Fattah, M., Chapple, C., Breeman, S., Cooper, D., Bell-Gorrod, H., Kuppanda, P., Guerrero, K., Dixon, S., Cotterill, N., Ward, K., Hashim, H., Monga, A., Brown, K., Drake, M., Gammie, A., Mostafa, A., Bruce, R., Bell, V., Kennedy, C., Evans, S., MacLennan, G., Norrie, J.

Πηγή: Health Technology Assessment, Vol 29, Iss 27 (2025)

Θεματικοί όροι: Adult, Technology Assessment, Biomedical, Biomedical, Cost-Benefit Analysis, Urinary Bladder, URODYNAMICS, State Medicine, Technology Assessment, Medical technology, Humans, R855-855.5, Aged, Urinary Bladder, Overactive, WOMEN, Middle Aged, 2719 Health Policy, United Kingdom, Urodynamics, Quality of Life, Female, women, Quality-Adjusted Life Years, RANDOMISED CONTROLLED TRIAL, randomised controlled trial, Overactive, REFRACTORY OVERACTIVE BLADDER, refractory overactive bladder, urodynamics

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40620147
https://doaj.org/article/72797d2bf942418cb74e5dceff676e3d
https://api.library.uq.edu.au/view/UQ:1ce5507
https://espace.library.uq.edu.au/view/UQ:1ce5507
https://eprints.whiterose.ac.uk/id/eprint/230123/

Neurogenic lower urinary tract dysfunction in rare paediatric conditions, part II – a joint report by the Neurourology Promotion Committee and Children and Young Adults Committee of the International Continence Society

Συγγραφείς: Kotes, S., Zivkovic, D., Gomes, C., Drake, M., Mosiello, G., Onem, K., De Wachter, S., Sinha, S.

Πηγή: In Continence December 2026 20

Migraine-associated common genetic variants confer greater risk of posterior vs. anterior circulation ischemic stroke☆

Συγγραφείς: Frid, P., Author, Xu, H., Author, Mitchell, B. D., Author, Drake, M., Author, Wasselius, J., Author, Gaynor, B., Author, Ryan, K., Author, Giese, A. K., Author, Schirmer, M., Author, Donahue, K. L., Author, Irie, R., Author, Bouts, M. J.R.J., Author, McIntosh, E. C., Author, Mocking, S. J.T., Author, Dalca, A. V., Author, Giralt-Steinhauer, E., Author, Holmegaard, Lukas, Author, Jood, K., Author, Roquer, J., Author, Cole, J. W., Author, McArdle, P. F., Author, Broderick, J. P., Author, Jimenez-Conde, J., Author, Jern, C., Author, Kissela, B. M., Author, Kleindorfer, D. O., Author, Lemmens, R., Author, Meschia, J. F., Author, Rosand, J., Author, Rundek, T., Author, Sacco, R. L., Author, Schmidt, R., Author, Sharma, P., Author, Slowik, A., Author, Thijs, V., Author, Woo, D., Author, Worrall, B. B., Author, Kittner, S. J., Author, Petersson, J., Author, Golland, P., Author, Wu, O., Author, Rost, N. S., Author, Lindgren, A., Author, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Stroke Imaging Research group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Stroke Imaging Research group, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Neurology, Lund, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Neurologi, Lund, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Neuroradiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Neuroradiologi, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Neurology, Lund, Stroke policy and quality register research, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Neurologi, Lund, Stroke policy och kvalitetsregisterforskning, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Neurology, Lund, Clinical Stroke Research Group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Neurologi, Lund, Klinisk strokeforskning, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator

Συνεισφορές: Frid, P., Author, Xu, H., Author, Mitchell, B. D., Author, Drake, M., Author, Wasselius, J., Author, Gaynor, B., Author, Ryan, K., Author, Giese, A. K., Author, Schirmer, M., Author, Donahue, K. L., Author, Irie, R., Author, Bouts, M. J.R.J., Author, McIntosh, E. C., Author, Mocking, S. J.T., Author, Dalca, A. V., Author, Giralt-Steinhauer, E., Author, Holmegaard, Lukas, Author, Jood, K., Author, Roquer, J., Author, Cole, J. W., Author, McArdle, P. F., Author, Broderick, J. P., Author, Jimenez-Conde, J., Author, Jern, C., Author, Kissela, B. M., Author, Kleindorfer, D. O., Author, Lemmens, R., Author, Meschia, J. F., Author, Rosand, J., Author, Rundek, T., Author, Sacco, R. L., Author, Schmidt, R., Author, Sharma, P., Author, Slowik, A., Author, Thijs, V., Author, Woo, D., Author, Worrall, B. B., Author, Kittner, S. J., Author, Petersson, J., Author, Golland, P., Author, Wu, O., Author, Rost, N. S., Author, Lindgren, A., Author, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Stroke Imaging Research group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Stroke Imaging Research group, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Neurology, Lund, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Neurologi, Lund, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section V, Diagnostic Radiology, (Lund), Neuroradiology, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion V, Diagnostisk radiologi, Lund, Neuroradiologi, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Neurology, Lund, Stroke policy and quality register research, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Neurologi, Lund, Stroke policy och kvalitetsregisterforskning, Originator, Lund University, Faculty of Medicine, Department of Clinical Sciences, Lund, Section IV, Neurology, Lund, Clinical Stroke Research Group, Lunds universitet, Medicinska fakulteten, Institutionen för kliniska vetenskaper, Lund, Sektion IV, Neurologi, Lund, Klinisk strokeforskning, Originator, Lund University, Profile areas and other strong research environments, Strategic research areas (SRA), EpiHealth: Epidemiology for Health, Lunds universitet, Profilområden och andra starka forskningsmiljöer, Strategiska forskningsområden (SFO), EpiHealth: Epidemiology for Health, Originator

Πηγή: Journal of Stroke and Cerebrovascular Diseases. 31(8)

Θεματικοί όροι: Medical and Health Sciences, Clinical Medicine, Neurology, Medicin och hälsovetenskap, Klinisk medicin, Neurologi

Σύνδεσμος πρόσβασης: https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106546

A Diazeniumdiolate Signal in Pseudomonas syringae Upregulates Virulence Factors and Promotes Survival in Plants

Συγγραφείς: Qiang Guo, Caitlin N. Vitro, Drake M. Crawford, Bo Li

Πηγή: Molecular Plant-Microbe Interactions, Vol 37, Iss 11, Pp 776-783 (2024)

Θεματικοί όροι: 0301 basic medicine, 0303 health sciences, Virulence, Virulence Factors, structure-activity relationship, Botany, quorum sensing, Pseudomonas syringae, Gene Expression Regulation, Bacterial, Microbiology, QR1-502, Up-Regulation, extracellular chemical signaling, RNA sequencing analysis, 03 medical and health sciences, Solanum lycopersicum, Bacterial Proteins, QK1-989, Operon, bacteria-plant interaction, Plant Diseases, Signal Transduction

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/39146356
https://doaj.org/article/42c31cb51cfe45ef85fdd85917c3cd6c

Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase

Συγγραφείς: Morgan, Gina L.^aff1, Li, Kelin^aff2, Crawford, Drake M.^aff1, Aubé, Jeffrey^{aff1, aff2}, Li, Bo^{aff1, aff3}

Πηγή: ACS Chemical Biology. 16(12):2776-2786

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acschembio.1c00623

Post-glacial stratigraphy and late Holocene record of great Cascadia earthquakes in Ozette Lake, Washington, USA

Συγγραφείς: Daniel S. Brothers, Brian L. Sherrod, Drake M. Singleton, Jason S. Padgett, Jenna C. Hill, Andrew C. Ritchie, Jared W. Kluesner, Peter Dartnell

Πηγή: Geosphere. 20:1315-1346

Θεματικοί όροι: 01 natural sciences, 0105 earth and related environmental sciences

Toward a model of uORF-mediated translational control: An integrated bioinformatic and experimental approach

Συγγραφείς: Hanson, B, Author, Svrzikapa, N, Author, Feng, N, Author, Friedrichsen, HJ, Author, Lennaárd, AJ, Author, Abuhamdah, R, Author, Hemmer, N, Author, Chwalenia, K, Author, Drake, M, Author, Jad, Y, Author

Συνεισφορές: Hanson, B, Author, Svrzikapa, N, Author, Feng, N, Author, Friedrichsen, HJ, Author, Lennaárd, AJ, Author, Abuhamdah, R, Author, Hemmer, N, Author, Chwalenia, K, Author, Drake, M, Author, Jad, Y, Author

Πηγή: bioRxiv.

Σύνδεσμος πρόσβασης: https://ki.se/en/research/search-research-information?t=2&query=id%3A1045645

9. Reductions in Hippocampal Subfield Volumes are Associated With Increased Anxiety and Cognitive Deficits in Adults Who Regularly Use Cannabis

Συγγραφείς: Olivia Carusi, Megan C. Hall, Jason A. John, Kellen M. McDonald, Hua Bai, Lauren K. Webert, Grant M. Garrison, Lauren T. Morrow, Drake M. Reinke, Hannah J. Okelberry, Hallie J. Johnson, Lucy K. Horne, Ryan J. Glesinger, Danielle L. Rice, Anna T. Coutant, Pamela E. May-Weeks, Giorgia Picci, Tony W. Wilson

Πηγή: Biological Psychiatry. 99:S103

Slip Rate for the Rose Canyon Fault through San Diego, California, Based on Analysis of GPS Data: Evidence for a Potential Rose Canyon–San Miguel-Vallecitos Fault Connection?

Συγγραφείς: Drake M. Singleton, Jillian M. Maloney, Duncan C. Agnew, Thomas K. Rockwell

Πηγή: Bulletin of the Seismological Society of America. 114:2751-2766

Θεματικοί όροι: 0301 basic medicine, 03 medical and health sciences, 01 natural sciences, 0105 earth and related environmental sciences

Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)‑2-Hydroxy-3-(nitromethyl)succinic acid

Συγγραφείς: Mellott, Drake M.^aff1, Torres, Dan^aff2, Krieger, Inna V.^aff1, Cameron, Scott A.^{aff2, aff4}, Moghadamchargari, Zahra^aff3, Laganowsky, Arthur^aff3, Sacchettini, James C.^{aff1, aff3}, Meek, Thomas D.^aff1, Harris, Lawrence D.^{aff2, aff4}

Πηγή: Journal of the American Chemical Society. 143(42):17666-17676

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/jacs.1c07970

Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases

Συγγραφείς: Li, Linfeng^aff1, Chenna, Bala C.^aff1, Yang, Kai S.^aff2, Cole, Taylor R.^aff1, Goodall, Zachary T.^aff1, Giardini, Miriam^aff3, Moghadamchargari, Zahra^aff2, Hernandez, Elizabeth A.^aff1, Gomez, Jana^aff1, Calvet, Claudia M.^aff3, Bernatchez, Jean A.^aff3, Mellott, Drake M.^aff1, Zhu, Jiyun^aff1, Rademacher, Andrew^aff1, Thomas, Diane^aff3, Blankenship, Lauren R.^aff2, Drelich, Aleksandra^aff4, Laganowsky, Arthur^aff2, Tseng, Chien-Te K.^aff4, Liu, Wenshe R.^{aff1, aff2}, Wand, A. Joshua^aff1, Cruz-Reyes, Jorge^aff1, Siqueira-Neto, Jair L.^aff3, Meek, Thomas D.^aff1

Πηγή: Journal of Medicinal Chemistry. 64(15):11267-11287

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00628

A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV‑2 Infection of Human and Monkey Cells

Συγγραφείς: Mellott, Drake M.^aff1d1, Tseng, Chien-Te^aff2, Drelich, Aleksandra^aff2, Fajtová, Pavla^{aff3, aff4}, Chenna, Bala C.^aff1d1, Kostomiris, Demetrios H.^aff1d1, Hsu, Jason^aff2, Zhu, Jiyun^aff1d1, Taylor, Zane W.^aff1d1, Kocurek, Klaudia I.^aff1d2, Tat, Vivian^aff2, Katzfuss, Ardala^aff1d1, Li, Linfeng^aff1d1, Giardini, Miriam A.^aff3, Skinner, Danielle^aff3, Hirata, Ken^aff3, Yoon, Michael C.^aff3, Beck, Sungjun^aff3, Carlin, Aaron F.^aff6, Clark, Alex E.^aff3, Beretta, Laura^aff3, Maneval, Daniel^aff5d1, Hook, Vivian^aff3, Frueh, Felix^aff5d1, Hurst, Brett L.^aff5d2, Wang, Hong^aff5d2, Raushel, Frank M.^aff1d2, O’Donoghue, Anthony J.^aff3, de Siqueira-Neto, Jair Lage^aff3, Meek, Thomas D.^aff1d1, McKerrow, James H.^aff3

Πηγή: ACS Chemical Biology. 16(4):642-650

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acschembio.0c00875

Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis-2,3-Epoxy-Succinic Acid

Συγγραφείς: Pham, Truc Viet^aff1, Mellott, Drake M.^aff1, Moghadamchargari, Zahra^aff2, Chen, Kevin^aff1, Krieger, Inna^aff1, Laganowsky, Arthur^aff2, Sacchettini, James C.^{aff1, aff2}, Meek, Thomas D.^aff1

Πηγή: ACS Chemical Biology. 16(3):463-470

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acschembio.0c00740

Efficacy and Outcome of Allogeneic Transplantation in IgD and Nonsecretory Myeloma. A Report on Behalf of the Myeloma Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation

Συγγραφείς: Morris, C, Author, Iacobelli, S, Author, Gahrton, G, Author, van, Biezen A, Author, Drake, M, Author, Garderet, L, Author, Potter, M, Author, Schattenberg, AV, Author, Cornelissen, JJ, Author, Hamladji, R-M, Author

Συνεισφορές: Morris, C, Author, Iacobelli, S, Author, Gahrton, G, Author, van, Biezen A, Author, Drake, M, Author, Garderet, L, Author, Potter, M, Author, Schattenberg, AV, Author, Cornelissen, JJ, Author, Hamladji, R-M, Author

Πηγή: TRANSPLANTATION AND CELLULAR THERAPY. 21(6):1054-1058

Σύνδεσμος πρόσβασης: https://ki.se/en/research/search-research-information?t=2&query=id%3A515474

Management approach matters: meeting seagrass recovery and carbon mitigation goals: Meeting seagrass recovery and carbon mitigation goals

Συγγραφείς: Ward, M, Dibble, C, Millington-Drake, M, Lynch, J, McGlathery, K, Lilley, RJ, Strong, AL, Wedding, LM

Πηγή: NPJ Ocean Sustain
npj Ocean Sustainability, Vol 4, Iss 1, Pp 1-11 (2025)

Θεματικοί όροι: Environmental sciences, GE1-350, GC1-1581, Oceanography, Article

Σύνδεσμος πρόσβασης: https://pubmed.ncbi.nlm.nih.gov/40331062
https://doaj.org/article/1a04f386529a409b96c62f19191bea24
https://research.rug.nl/en/publications/99b11dc0-285a-4849-b676-b09901699f1a
https://hdl.handle.net/11370/99b11dc0-285a-4849-b676-b09901699f1a
https://doi.org/10.1038/s44183-025-00111-y
https://ora.ox.ac.uk/objects/uuid:98d6fce5-197a-4932-bb05-c2dca9b905f6
https://doi.org/10.1038/s44183-025-00111-y

Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity

Συγγραφείς: Chenna, Bala C.^aff1, Li, Linfeng^aff1, Mellott, Drake M.^aff1, Zhai, Xiang^aff1, Siqueira-Neto, Jair L.^aff2, Calvet Alvarez, Claudia^aff2, Bernatchez, Jean A.^aff2, Desormeaux, Emily^aff1, Alvarez Hernandez, Elizabeth^aff1, Gomez, Jana^aff1, McKerrow, James H.^aff2, Cruz-Reyes, Jorge^aff1, Meek, Thomas D.^aff1

Πηγή: Journal of Medicinal Chemistry. 63(6):3298-3316

Διαθεσιμότητα: https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b02078