A systematic review of heterogeneity in clinical trial design for anal cancer radiotherapy-immunotherapy combinations

Συγγραφείς: Robert J. Samuel, Adel Samson, Duncan C. Gilbert, Richard Adams, Andrew Renehan, Natalie Cook, David Sebag-Montefiore, Sarah Brown

Πηγή: Clinical and Translational Radiation Oncology, Vol 61, Iss , Pp 101243- (2026)

Θεματικοί όροι: Anal Cancer, Radiotherapy, Clinical Trials, Immunotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405630826001382; https://doaj.org/toc/2405-6308

Σύνδεσμος πρόσβασης: https://doaj.org/article/9f3facd271754585a97eb866b367f802

An international multi-centre study to develop and validate federated learning-based prognostic models for anal cancer

Συγγραφείς: Stelios Theophanous, Per-Ivar Lønne, Ananya Choudhury, Maaike Berbee, Charlotte Deijen, Andre Dekker, Matthew Field, Maria Antonietta Gambacorta, Alexandra Gilbert, Marianne Grønlie Guren, Rashmi Jadon, Rohit Kochhar, Daniel Martin, Ahmed Allam Mohamed, Rebecca Muirhead, Oriol Parés, Łukasz Raszewski, Rajarshi Roy, Andrew Scarsbrook, David Sebag-Montefiore, Emiliano Spezi, Vassilios Vassiliou, Eirik Malinen, Leonard Wee, Ane Appelt, atomCAT Consortium

Πηγή: Nature Communications, Vol 17, Iss 1 (2026)

Θεματικοί όροι: Science

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2041-1723

Σύνδεσμος πρόσβασης: https://doaj.org/article/c480d6f159114d3f936387a1e0bb2f18

Personalising anal cancer radiotherapy dose (PLATO): protocol for a multicentre integrated platform trial

Συγγραφείς: Mark Harrison, Vicky Goh, Lindy Berkman, Sarah Brown, Alexandra Smith, Sheela Rao, Susan D Richman, Andrew G Renehan, David Sebag-Montefiore, Natalie L Abbott, Richard Adams, Sharon P Ruddock, Alexandra Gilbert, Maria Hawkins, Rebecca Muirhead, Joanne Webster, Russell Frood, Duncan Gilbert, Joanne Copeland

Πηγή: BMJ Open, Vol 15, Iss 11 (2025)

Θεματικοί όροι: Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://bmjopen.bmj.com/content/15/11/e109655.full; https://doaj.org/toc/2044-6055

Σύνδεσμος πρόσβασης: https://doaj.org/article/4b97cb6ac06e4562a7a3d183c91cab74

Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy

Συγγραφείς: Maxime W. Lafarge, Enric Domingo, Korsuk Sirinukunwattana, Ruby Wood, Leslie Samuel, Graeme Murray, Susan D. Richman, Andrew Blake, David Sebag-Montefiore, Simon Gollins, Eckhard Klieser, Daniel Neureiter, Florian Huemer, Richard Greil, Philip Dunne, Philip Quirke, Lukas Weiss, Jens Rittscher, Tim Maughan, Viktor H. Koelzer

Πηγή: npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)

Θεματικοί όροι: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2397-768X

Σύνδεσμος πρόσβασης: https://doaj.org/article/069ba3e2373e479787af9c5a62731f11

International consensus to define outcomes for trials of chemoradiotherapy for anal cancer (CORMAC-2): defining the outcomes from the CORMAC core outcome set

Συγγραφείς: Robert Samuel, Stephen R. Knight, Richard Adams, Prajnan Das, Jennifer Dorth, David Finch, Marianne G. Guren, Maria A. Hawkins, Susan Moug, Lakshmi Rajdev, David Sebag-Montefiore, Andrew G. Renehan, Rebecca Fish, Miguel A. Rodriguez-Bigas, Pratik Adusumilli, Ahmed Allam Mohamed, Mario Alvarez Gallego, Eva Angenete, Ane Appelt, Maaike Berbee, Danielle Brogden, Peter Brown, Lucy Buckley, Nathalie Casanova, Rachel Cooper, Nuno Couto, Peter Coyne, Tamzin Cuming, Charlotte Deijin, Kristopher Dennis, Cathy Eng, Alexandra Gilbert, Duncan Gilbert, Karyn Goodman, Rashmi Jadon, Anders Johnsson, Arunansu Kar, Ethan Ludmir, Marie-Louise Lydrup, Ivan Lyra-Gonzalez, Stefania Manfrida, Rebecca Muirhead, Sarah O'Dwyer, Thomas Rackley, Lukasz Raszewski, Leslie Samuel, Mark Saunders, Andrew Scarsbrook, Eva Segelov, Timothy Simmons, Paul Sutton, Nicholas Symons, Deborah Williamson

Πηγή: EClinicalMedicine, Vol 78, Iss , Pp 102939- (2024)

Θεματικοί όροι: Core outcome set, Outcomes, Anal cancer, Consensus, Delphi, Chemoradiotherapy, Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589537024005182; https://doaj.org/toc/2589-5370

Σύνδεσμος πρόσβασης: https://doaj.org/article/13141decd4db43eeae1e82431775d0e8

Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictorsResearch in context

Συγγραφείς: Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Francesca Buffa, Geoffrey Higgins, Christopher Holmes, Timothy Maughan, Gillies McKenna, James Robineau, Philip Quirke, Matthew Seymour, Richard Kennedy, Mark Lawler, Manuel Salto-Tellez, Peter Campbell, Claire Hardy, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Richard Wilson, Richard Adams, Richard Sullivan, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan

Πηγή: EBioMedicine, Vol 106, Iss , Pp 105228- (2024)

Θεματικοί όροι: Rectal neoplasms, Radiotherapy, Precision medicine, Prediction, TGFβ, Immune response, Medicine, Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396424002639; https://doaj.org/toc/2352-3964

Σύνδεσμος πρόσβασης: https://doaj.org/article/6732596b11c54a618ebd9beb8dd8725c

Brain Re-Irradiation Or Chemotherapy: a phase II randomised trial of re-irradiation and chemotherapy in patients with recurrent glioblastoma (BRIOChe) – protocol for a multi-centre open-label randomised trial

Συγγραφείς: Stuart Currie, Alexandra Smith, David Sebag-Montefiore, Helen Bulbeck, Jane Hughes, Susan Short, Eleanor M Hudson, Samantha Noutch, Catherine Parbutt, Louise Murray, Joanne Webster, Sarah R Brown, Florien W Boele, Omar Al-Salihi, Helen Baines, Sharon Fernandez, John Lilley, Finbar Slevin

Πηγή: BMJ Open, Vol 14, Iss 3 (2024)

Θεματικοί όροι: Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://bmjopen.bmj.com/content/14/3/e078926.full; https://doaj.org/toc/2044-6055

Σύνδεσμος πρόσβασης: https://doaj.org/article/8f776f291e5c495981ce04e1bab3b6f3

Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units

Συγγραφείς: Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes

Πηγή: Trials, Vol 23, Iss 1, Pp 1-14 (2022)

Θεματικοί όροι: Platform protocols, Trial conduct, Multi-arm multi-stage trials, Umbrella trials, Basket trials, Stratified medicine, Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1745-6215

Σύνδεσμος πρόσβασης: https://doaj.org/article/f16f51eff76c45b9b2545597e35df8a3

Development and validation of prognostic models for anal cancer outcomes using distributed learning: protocol for the international multi-centre atomCAT2 study

Συγγραφείς: Stelios Theophanous, Per-Ivar Lønne, Ananya Choudhury, Maaike Berbee, Andre Dekker, Kristopher Dennis, Alice Dewdney, Maria Antonietta Gambacorta, Alexandra Gilbert, Marianne Grønlie Guren, Lois Holloway, Rashmi Jadon, Rohit Kochhar, Ahmed Allam Mohamed, Rebecca Muirhead, Oriol Parés, Lukasz Raszewski, Rajarshi Roy, Andrew Scarsbrook, David Sebag-Montefiore, Emiliano Spezi, Karen-Lise Garm Spindler, Baukelien van Triest, Vassilios Vassiliou, Eirik Malinen, Leonard Wee, Ane L. Appelt, on behalf of the atomCAT consortium

Πηγή: Diagnostic and Prognostic Research, Vol 6, Iss 1, Pp 1-11 (2022)

Θεματικοί όροι: Anal cancer, Squamous cell carcinoma, Chemoradiotherapy, Distributed learning, Federated learning, outcome modelling, Medicine (General), R5-920

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/2397-7523

Σύνδεσμος πρόσβασης: https://doaj.org/article/127c2bcc438a47df81818d07dee02177

Prognostic factors for patients with anal cancer treated with conformal radiotherapy—a systematic review

Συγγραφείς: Stelios Theophanous, Robert Samuel, John Lilley, Ann Henry, David Sebag-Montefiore, Alexandra Gilbert, Ane L. Appelt

Πηγή: BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)

Θεματικοί όροι: Systematic review, Anal cancer, Squamous cell carcinoma, Conformal radiotherapy, IMRT, VMAT, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1471-2407

Σύνδεσμος πρόσβασης: https://doaj.org/article/e3774f9728094c7cb3457dd3f3e3abcb

Bayesian network structure for predicting local tumor recurrence in rectal cancer patients treated with neoadjuvant chemoradiation followed by surgery

Συγγραφείς: Biche Osong, Carlotta Masciocchi, Andrea Damiani, Inigo Bermejo, Elisa Meldolesi, Giuditta Chiloiro, Maaike Berbee, Seok Ho Lee, Andre Dekker, Vincenzo Valentini, Jean-Pierre Gerard, Claus Rödel, Krzysztof Bujko, Cornelis van de Velde, Joakim Folkesson, Aldo Sainato, Robert Glynne-Jones, Samuel Ngan, Morten Brændengen, David Sebag-Montefiore, Johan van Soest

Πηγή: Physics and Imaging in Radiation Oncology, Vol 22, Iss , Pp 1-7 (2022)

Θεματικοί όροι: Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405631622000264; https://doaj.org/toc/2405-6316

Σύνδεσμος πρόσβασης: https://doaj.org/article/3c2783db66b2494396a0347753924d73

Patient-reported outcomes in PROSPECT trial (Alliance N1048) – FOLFOX is not a panacea

Συγγραφείς: Sean M. O'Cathail, Richard Adams, Maria A. Hawkins, David Sebag-Montefiore, Corrie A.M. Marijnen, Emmanouil Fokas

Πηγή: Clinical and Translational Radiation Oncology, Vol 43, Iss , Pp 100672- (2023)

Θεματικοί όροι: Rectal cancer, Trials, PROSPECT, QoL, Radiotherapy, Chemotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405630823000976; https://doaj.org/toc/2405-6308

Σύνδεσμος πρόσβασης: https://doaj.org/article/bc8ff86a38d54de1bc04939d282434d6

Patient position verification in magnetic-resonance imaging only radiotherapy of anal and rectal cancers

Συγγραφείς: David Bird, Matthew Beasley, Michael G. Nix, Marcus Tyyger, Hazel McCallum, Mark Teo, Alexandra Gilbert, Nathalie Casanova, Rachel Cooper, David L. Buckley, David Sebag-Montefiore, Richard Speight, Ann M. Henry, Bashar Al-Qaisieh

Πηγή: Physics and Imaging in Radiation Oncology, Vol 19, Iss , Pp 72-77 (2021)

Θεματικοί όροι: MR-only, MRI-only, Anal cancer, Rectal cancer, CBCT patient positioning, CBCT, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405631621000403; https://doaj.org/toc/2405-6316

Σύνδεσμος πρόσβασης: https://doaj.org/article/4a9476eb08b64da9947c029482046880

Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study

Συγγραφείς: Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, Mark P. Saunders, Matthew Sperrin, David Sebag-Montefiore, Marcel van Herk, Andrew G. Renehan

Πηγή: BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)

Θεματικοί όροι: Anal cancer, Tumour volume, Loco-regional failure, Prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: https://doaj.org/toc/1471-2407

Σύνδεσμος πρόσβασης: https://doaj.org/article/260f5d62288a4aa180f57e86cafd2a5e

A Phase II trial of Higher RadiOtherapy Dose In The Eradication of early rectal cancer (APHRODITE): protocol for a multicentre, open-label randomised controlled trial

Συγγραφείς: Nicholas West, Sarah Brown, Alexandra Smith, Mark Saunders, Amanda Webster, David Sebag-Montefiore, Mark Teo, Simon Gollins, Jenny Seligmann, Simon P Bach, Monica Jefford, Alexandra Gilbert, Eleanor M Hudson, Samantha Noutch, Ravi Adapala, Carole Burnett, Alwyn Burrage, Maria Hawkins, Debra Howard, Rohit Kochhar, Edward JD Webb, Ane L Appelt

Πηγή: BMJ Open, Vol 12, Iss 4 (2022)

Θεματικοί όροι: Medicine

Περιγραφή αρχείου: electronic resource

Relation: https://bmjopen.bmj.com/content/12/4/e049119.full; https://doaj.org/toc/2044-6055

Σύνδεσμος πρόσβασης: https://doaj.org/article/5076921d830b40879b4eaba34fff4948

A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR)

Συγγραφείς: Séan M. O’Cathail, Steven Davis, Jane Holmes, Richard Brown, Kerry Fisher, Leonard Seymour, Richard Adams, James Good, David Sebag-Montefiore, Tim Maughan, Maria A. Hawkins

Πηγή: Radiation Oncology, Vol 15, Iss 1, Pp 1-8 (2020)

Θεματικοί όροι: Radiation, Phase I, Rectal, Cancer, Oncolytic virus, Immuno-oncology, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://link.springer.com/article/10.1186/s13014-020-01593-5; https://doaj.org/toc/1748-717X

Σύνδεσμος πρόσβασης: https://doaj.org/article/7ce2e9a046514028ab5f12e3e58832fd

Mesorectal radiotherapy for early stage rectal cancer: A novel target volume

Συγγραφείς: Femke P. Peters, Mark T.W. Teo, Ane L. Appelt, Simon Bach, Gunnar Baatrup, Johannes H.W. de Wilt, Camilla Jensenius Kronborg, Karen-Lise Garm Spindler, Corrie A.M. Marijnen, David Sebag-Montefiore

Πηγή: Clinical and Translational Radiation Oncology, Vol 21, Iss , Pp 104-111 (2020)

Θεματικοί όροι: Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405630820300070; https://doaj.org/toc/2405-6308

Σύνδεσμος πρόσβασης: https://doaj.org/article/8d8ec8bd19fa41fbb8f9f3107a48773d

Systematic review of methodology used in clinical studies evaluating the benefits of proton beam therapy

Συγγραφείς: Mercy Ofuya, Lucy McParland, Louise Murray, Sarah Brown, David Sebag-Montefiore, Emma Hall

Πηγή: Clinical and Translational Radiation Oncology, Vol 19, Iss , Pp 17-26 (2019)

Θεματικοί όροι: Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405630819300850; https://doaj.org/toc/2405-6308

Σύνδεσμος πρόσβασης: https://doaj.org/article/f0dacc66928349ecb1db2e8a963c4f3b

Robust dose planning objectives for mesorectal radiotherapy of early stage rectal cancer – A multicentre dose planning study

Συγγραφείς: Ane L. Appelt, Ellen M. Kerkhof, Lars Nyvang, Ernst C. Harderwijk, Natalie L. Abbott, Mark Teo, Femke P. Peters, Camilla J.S. Kronborg, Karen-Lise G. Spindler, David Sebag-Montefiore, Corrie A.M. Marijnen

Πηγή: Technical Innovations & Patient Support in Radiation Oncology, Vol 11, Iss , Pp 14-21 (2019)

Θεματικοί όροι: Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405632419300101; https://doaj.org/toc/2405-6324

Σύνδεσμος πρόσβασης: https://doaj.org/article/79548a38b7ac4ac98c50c208f3fa217e

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2)

Συγγραφείς: Victoria Y. Strauss, Rachel Shaw, Pradeep S. Virdee, Christopher N. Hurt, Elizabeth Ward, Bethan Tranter, Neel Patel, John Bridgewater, Philip Parsons, Ganesh Radhakrishna, Eric O’Neill, David Sebag-Montefiore, Maria Hawkins, Pippa G. Corrie, Timothy Maughan, Somnath Mukherjee

Πηγή: BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)

Θεματικοί όροι: Locally advanced pancreatic cancer (LAPC), Chemoradiation, Gemcitabine and nab-paclitaxel (GEMABX), Nelfinavir, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

Περιγραφή αρχείου: electronic resource

Relation: http://link.springer.com/article/10.1186/s12885-019-5307-z; https://doaj.org/toc/1471-2407

Σύνδεσμος πρόσβασης: https://doaj.org/article/e5a8e148f1a2441296f4f252ecbfeb35