Acoustofluidic cryo-EM enables in situ particle manipulation for uniform, high-quality cryo-EM specimens.

Συγγραφείς: Yang K; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Peele W; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC 27709, USA., Liu P; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Xia J; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Dandey V; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC 27709, USA., Zhong R; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Jin K; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Sharma K; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC 27709, USA., Watson AJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC 27709, USA.; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Yang S; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Chen Y; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Agahtehrani A; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Lan SN; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Zhang P; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Tian Z; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Liu M; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Viverette E; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC 27709, USA., Xu X; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Wu Q; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA., Borgnia MJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC 27709, USA., Lee LP; Harvard Medical School, Harvard University; and Renal Division and Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA.; Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, Korea.; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, Korea., Huang TJ; Thomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.

Πηγή: Science advances [Sci Adv] 2026 Sep 25; Vol. 12 (39), pp. eaeh5900. Date of Electronic Publication: 2026 Sep 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Cryoelectron Microscopy*/instrumentation , Specimen Handling*/methods , Acoustics*, Apoferritins/chemistry ; Liposomes/chemistry ; Liposomes/ultrastructure

Meet the author: Stefan Raunser.

Συγγραφείς: Raunser S

Πηγή: Structure (London, England : 1993) [Structure] 2026 Sep 03; Vol. 34 (9), pp. 1210.

Τύπος έκδοσης: Interview; Historical Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Cryoelectron Microscopy*/history , Electron Microscope Tomography*/methods , Electron Microscope Tomography*/history, History, 21st Century ; History, 20th Century

Designing and Operating an In-House Cryogenic Electron Microscopy Facility with IT Infrastructure and On-the-Fly Data Processing Pipelines.

Συγγραφείς: Shell E; ITS-Technology Engineering, Information Technology Services, Physical & Biological Sciences Division, University of California-Santa Cruz.; Biomolecular Cryo-Electron Microscopy Facility, University of California-Santa Cruz., Balasco Serrão VH; Biomolecular Cryo-Electron Microscopy Facility, University of California-Santa Cruz.; Chemistry and Biochemistry Department, University of California-Santa Cruz; vbalasco@ucsc.edu.

Πηγή: Journal of visualized experiments : JoVE [J Vis Exp] 2026 Sep 01 (235). Date of Electronic Publication: 2026 Sep 01.

Τύπος έκδοσης: Journal Article; Video-Audio Media

Στοιχεία περιοδικού: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/instrumentation , Cryoelectron Microscopy*/methods

Direct deposition on pre-cooled grids: a new approach to sub-millisecond cryoEM grid preparation.

Συγγραφείς: Klebl DP; School of Biomedical Sciences, Faculty of Biomedical Sciences and Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom., Kay RW; School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom., McMillan S; School of Biomedical Sciences, Faculty of Biomedical Sciences and Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom., Sobott F; School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom., Kapur N; School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom., Muench SP; School of Biomedical Sciences, Faculty of Biomedical Sciences and Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.

Πηγή: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2026 Sep 01; Vol. 82 (Pt 9), pp. 1056-1061. Date of Electronic Publication: 2026 Aug 11.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101676043 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7983 (Electronic) Linking ISSN: 20597983 NLM ISO Abbreviation: Acta Crystallogr D Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Cryoelectron Microscopy*/instrumentation , Specimen Handling*/methods

Automated LN₂ refill device for uninterrupted cryoFIB-SEM operations.

Συγγραφείς: Gonda I; Center for Microscopy and Image Analysis, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Junker D; Additive Manufacturing Facility, Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Eggimann F; Additive Manufacturing Facility, Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Kaech A; Center for Microscopy and Image Analysis, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland., Szwedziak P; Center for Microscopy and Image Analysis, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: piotr.szwedziak@zmb.uzh.ch.

Πηγή: Journal of structural biology [J Struct Biol] 2026 Sep; Vol. 218 (3), pp. 108350. Date of Electronic Publication: 2026 Jul 20.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 9011206 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8657 (Electronic) Linking ISSN: 10478477 NLM ISO Abbreviation: J Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Cryoelectron Microscopy*/instrumentation , Microscopy, Electron, Scanning*/methods , Microscopy, Electron, Scanning*/instrumentation , Cryopreservation*/methods , Cryopreservation*/instrumentation, Automation

Detailed Preparation of Ni-NTA Lipid Monolayer Affinity Grids for Cryo-EM Structural Analysis of Soluble Polyhistidine-Tagged Protein Complexes.

Συγγραφείς: Lenger C; Department of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine., Yoon D; Department of Electrical and Computer Engineering, North Carolina State University., Franco IC; Department of Chemistry and Biochemistry, Division of Physical and Biological Sciences, University of California Santa Cruz., Skrajna A; Department of Chemistry and Biochemistry, Division of Physical and Biological Sciences, University of California Santa Cruz., Baker RW; Department of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; UNC Lineberger Comprehensive Cancer Center, UNC Chapel Hill School of Medicine; baker@med.unc.edu., Strauss JD; Department of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Joshua_Strauss@med.unc.edu.

Πηγή: Journal of visualized experiments : JoVE [J Vis Exp] 2026 Aug 04 (234). Date of Electronic Publication: 2026 Aug 04.

Τύπος έκδοσης: Journal Article; Video-Audio Media; Research Support, N.I.H., Extramural

Στοιχεία περιοδικού: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Histidine*/chemistry , Lipids*/chemistry , Cryoelectron Microscopy*/methods , Cryoelectron Microscopy*/instrumentation , Proteins*/chemistry , Nitrilotriacetic Acid*/analogs & derivatives , Nitrilotriacetic Acid*/chemistry , Organometallic Compounds*/chemistry, Nickel/chemistry

LowDoseWizard: rapid and standardized setup of low-dose cryo-TEM imaging in SerialEM.

Συγγραφείς: Fromm SA; EMBL Imaging Centre, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany., Mattei S; EMBL Imaging Centre, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Πηγή: Acta crystallographica. Section D, Structural biology [Acta Crystallogr D Struct Biol] 2026 Aug 01; Vol. 82 (Pt 8), pp. 990-997. Date of Electronic Publication: 2026 Jul 28.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101676043 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7983 (Electronic) Linking ISSN: 20597983 NLM ISO Abbreviation: Acta Crystallogr D Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Cryoelectron Microscopy*/standards , Microscopy, Electron, Transmission*/methods , Software*, Image Processing, Computer-Assisted/methods

High-resolution cryoEM of nucleosomes in nuclear extracts of mammalian cells.

Συγγραφείς: Ker DS; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K., Aboalnaga H; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K., Pellegrini L; Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, U.K.

Πηγή: Bioscience reports [Biosci Rep] 2026 Oct 21; Vol. 46 (10).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 8102797 Publication Model: Print Cited Medium: Internet ISSN: 1573-4935 (Electronic) Linking ISSN: 01448463 NLM ISO Abbreviation: Biosci Rep Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Nucleosomes*/ultrastructure , Nucleosomes*/chemistry , Cryoelectron Microscopy*/methods , Cell Nucleus*/ultrastructure, Humans

Reaction-based cryo-EM resolves the continuous conformational spectrum of CTP synthase catalysis.

Συγγραφείς: Guo CJ; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Wu YF; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Guo SY; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Fu Y; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Wang W; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China., Liu JL; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom.

Πηγή: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Oct 20; Vol. 123 (42), pp. e2620271123. Date of Electronic Publication: 2026 Oct 09.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Carbon-Nitrogen Ligases*/chemistry , Carbon-Nitrogen Ligases*/metabolism , Carbon-Nitrogen Ligases*/ultrastructure , Drosophila melanogaster*/enzymology, Adenosine Triphosphate/metabolism ; Adenosine Triphosphate/chemistry ; Uridine Triphosphate/metabolism ; Uridine Triphosphate/analogs & derivatives ; Uridine Triphosphate/chemistry ; Cytidine Triphosphate/metabolism ; Cytidine Triphosphate/chemistry ; Animals ; Protein Conformation ; Models, Molecular ; Phosphorylation ; Catalysis ; Biocatalysis

Single-particle cryoEM: Theory and practice.

Συγγραφείς: Patwardhan A; Cellular Structure & 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), UK., Rosenthal PB; Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute, London, UK., Russo CJ; MRC Laboratory of Molecular Biology, Cambridge, UK., Henderson R; MRC Laboratory of Molecular Biology, Cambridge, UK.

Πηγή: Quarterly reviews of biophysics [Q Rev Biophys] 2026 Oct 15; Vol. 59, pp. e16. Date of Electronic Publication: 2026 Oct 15.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0144032 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-8994 (Electronic) Linking ISSN: 00335835 NLM ISO Abbreviation: Q Rev Biophys Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Single Molecule Imaging*/methods

Blender as a Tool for Visualization and Animation of the Trypanosome Flagellar Base Using Cryogenic Electron Tomography.

Συγγραφείς: Hildebolt H; Department of Biophysics, University of Michigan, Ann Arbor., Staggers SR; Department of Structural Biology, University of Pittsburgh., Sun SY; Department of Structural Biology, University of Pittsburgh; stellasun@pitt.edu.

Πηγή: Journal of visualized experiments : JoVE [J Vis Exp] 2026 Oct 09 (236). Date of Electronic Publication: 2026 Oct 09.

Τύπος έκδοσης: Journal Article; Video-Audio Media

Στοιχεία περιοδικού: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Electron Microscope Tomography*/methods , Flagella*/ultrastructure , Cryoelectron Microscopy*/methods , Trypanosoma brucei brucei*/ultrastructure , Software*, Imaging, Three-Dimensional/methods

Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR.

Συγγραφείς: Xiao T; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Kovinko A; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Shi C; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, China., Sawczyc H; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Qoraj D; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Öster C; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Sprink T; Core Facility for Cryo-Electron Microscopy of the Charité-Universitätsmedizin Berlin at the Max Delbrück Center, Berlin, Germany.; Max Delbrück Center for Molecular Medicine, Technology Platform Cryo-EM, Berlin, Germany., Ketzel AF; Research Unit Structural Chemistry and Computational Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Chemistry, Technische Universität Berlin, Berlin, Germany., Lange S; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Kosteletos S; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Sun H; Research Unit Structural Chemistry and Computational Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Chemistry, Technische Universität Berlin, Berlin, Germany., Roderer D; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany., Chen S; Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Lange A; Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.; Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.

Πηγή: Science advances [Sci Adv] 2026 Oct 09; Vol. 12 (41), pp. eaei0096. Date of Electronic Publication: 2026 Oct 07.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Escherichia coli Proteins*/chemistry , Escherichia coli Proteins*/genetics , Escherichia coli Proteins*/metabolism , Ion Channels*/chemistry , Ion Channels*/genetics , Ion Channels*/metabolism , Ion Channels*/ultrastructure , Escherichia coli*/metabolism , Escherichia coli*/genetics , Cryoelectron Microscopy* , Mechanotransduction, Cellular*, Liposomes/chemistry ; Protein Conformation ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Mutation

A biased allosteric modulator is a molecular glue for β2AR dimerization.

Συγγραφείς: Shen J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Peddada TN; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Komolov KE; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., De Pascali F; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Garces AM; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA., Wang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Ehsan M; Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea., Chae PS; Department of Bionano Engineering, Center for Bionano Intelligence Education and Research, Hanyang University, Ansan, South Korea., Lerch MT; Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA., Benovic JL; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA., Xu J; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. xuj8@sustech.edu.cn.; Department of Medical Neuroscience, SUSTech Homeostatic Medicine Institute, School of Medicine, Institute for Biology Electron Microscopy, Southern University of Science and Technology, Shenzhen, China. xuj8@sustech.edu.cn., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kobilka@stanford.edu.

Πηγή: Nature [Nature] 2026 Oct; Vol. 658 (8135), pp. 556-564. Date of Electronic Publication: 2026 Aug 19.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Protein Multimerization*/drug effects , Receptors, Adrenergic, beta-2*/chemistry , Receptors, Adrenergic, beta-2*/metabolism , Receptors, Adrenergic, beta-2*/ultrastructure , Cryoelectron Microscopy*, Allosteric Regulation/drug effects ; beta-Arrestins/metabolism ; beta-Arrestins/chemistry ; Signal Transduction/drug effects ; Animals ; Humans ; HEK293 Cells ; Ligands ; Models, Molecular ; Dimerization

Structural mechanism governing the directionality of bridge recombination.

Συγγραφείς: Hiraizumi M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Athukoralage JS; Arc Institute, Palo Alto, CA, USA., Perry NT; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.; San Francisco Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Tsujimoto E; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Shiojiri N; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Nagahata N; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Lee L; Arc Institute, Palo Alto, CA, USA., Sun G; Arc Institute, Palo Alto, CA, USA., Durrant MG; Arc Institute, Palo Alto, CA, USA.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Chandrasekaran SS; Arc Institute, Palo Alto, CA, USA., Konermann S; Arc Institute, Palo Alto, CA, USA.; Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA, USA., Yamashita K; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Hsu PD; Arc Institute, Palo Alto, CA, USA. patrick@arcinstitute.org.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. patrick@arcinstitute.org.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. patrick@arcinstitute.org.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. patrick@arcinstitute.org., Nishimasu H; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. nisimasu@g.ecc.u-tokyo.ac.jp.; Structural Biology Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan. nisimasu@g.ecc.u-tokyo.ac.jp.; Inamori Research Institute for Science, Kyoto, Japan. nisimasu@g.ecc.u-tokyo.ac.jp.

Πηγή: Nature [Nature] 2026 Oct; Vol. 658 (8134), pp. 269-278. Date of Electronic Publication: 2026 Aug 12.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Escherichia coli*/genetics , Escherichia coli*/enzymology , DNA Transposable Elements*/genetics , Recombinases*/metabolism , Recombinases*/chemistry , Recombinases*/ultrastructure , Recombination, Genetic* , Cryoelectron Microscopy*, DNA, Circular/genetics ; DNA, Circular/chemistry ; DNA, Circular/metabolism ; DNA, Circular/ultrastructure ; DNA/chemistry ; DNA/metabolism ; DNA/ultrastructure ; DNA/genetics ; Models, Molecular ; Substrate Specificity

Current challenges in cryogenic super-resolution fluorescence microscopy in the context of cryogenic electron microscopy/tomography.

Συγγραφείς: Falckenhayn J; Centre for Structural Systems Biology, Notkestraße 85, C/o DESY, Geb. 15, 22607 Hamburg, Germany; Department of Physics, University of Hamburg, Notkestraße 9-11, 22607 Hamburg, Germany., Kaufmann R; Centre for Structural Systems Biology, Notkestraße 85, C/o DESY, Geb. 15, 22607 Hamburg, Germany; Department of Physics, University of Hamburg, Notkestraße 9-11, 22607 Hamburg, Germany. Electronic address: rainer.kaufmann@cssb-hamburg.de.

Πηγή: Current opinion in structural biology [Curr Opin Struct Biol] 2026 Oct; Vol. 100, pp. 103338. Date of Electronic Publication: 2026 Jul 17.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 9107784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-033X (Electronic) Linking ISSN: 0959440X NLM ISO Abbreviation: Curr Opin Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Electron Microscope Tomography*/methods, Microscopy, Fluorescence/methods ; Single Molecule Imaging/methods

Transforming cryo-lift-out one section at a time.

Συγγραφείς: Perone G; Human Technopole, Milan, Italy., Cottom CO; Human Technopole, Milan, Italy., Erdmann PS; Human Technopole, Milan, Italy. Electronic address: philipp.erdmann@fht.org.

Πηγή: Current opinion in structural biology [Curr Opin Struct Biol] 2026 Oct; Vol. 100, pp. 103327. Date of Electronic Publication: 2026 Jul 14.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 9107784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-033X (Electronic) Linking ISSN: 0959440X NLM ISO Abbreviation: Curr Opin Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Electron Microscope Tomography*/methods, Animals ; Humans

Cryo-EM Structures of Phage T4 Infection Intermediate.

Συγγραφείς: Shao Q; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China., Dong J; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China., Wang A; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China., Hu H; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China., Yue J; Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA; Microbial Sciences Institute, Yale University, West Haven, CT, USA., Li H; State Key Lab for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China., Li Y; State Key Lab for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China., Zhang Q; State Key Lab for Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China., Liu J; Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA; Microbial Sciences Institute, Yale University, West Haven, CT, USA., Sun L; Shanghai Fifth People's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China., Fokine A; Department of Biological Sciences, Purdue University, West Lafayette, IN, USA., Rao VB; Bacteriophage Medical Research Center, Department of Biology, The Catholic University of America, Washington, DC, USA. Electronic address: rao@cua.edu., Tao P; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China. Electronic address: taopan@mail.hzau.edu.cn., Fang Q; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong, China. Electronic address: fangqlin3@mail.sysu.edu.cn.

Πηγή: Journal of molecular biology [J Mol Biol] 2026 Oct 01; Vol. 438 (19), pp. 169938. Date of Electronic Publication: 2026 Jul 04.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods , Bacteriophage T4*/ultrastructure , Bacteriophage T4*/genetics , Bacteriophage T4*/physiology, DNA, Viral/genetics ; Virion/ultrastructure ; Viral Proteins/metabolism ; Genome, Viral

A comparative review of cryo-electron ptychography: Biological applications and future perspectives.

Συγγραφείς: Li S; Key Laboratory for Protein Sciences of Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China; State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Joint Center for Life Sciences, Beijing 100084, China; Beijing Frontier Research Center for Biological Structure, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China; Shenzhen Medical Academy of Research and Translation, Shenzhen 518100, China., Li X; Key Laboratory for Protein Sciences of Ministry of Education, School of Life Sciences, Tsinghua University, Beijing 100084, China; State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Joint Center for Life Sciences, Beijing 100084, China; Beijing Frontier Research Center for Biological Structure, Beijing 100084, China; School of Life Sciences, Tsinghua University, Beijing 100084, China; Shenzhen Medical Academy of Research and Translation, Shenzhen 518100, China. Electronic address: lixueming@tsinghua.edu.cn.

Πηγή: Current opinion in structural biology [Curr Opin Struct Biol] 2026 Oct; Vol. 100, pp. 103320. Date of Electronic Publication: 2026 Jul 01.

Τύπος έκδοσης: Journal Article; Review; Comparative Study

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 9107784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-033X (Electronic) Linking ISSN: 0959440X NLM ISO Abbreviation: Curr Opin Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Cryoelectron Microscopy*/methods, Humans ; Animals ; Algorithms

Tomogram exploration through template matching and deep learning.

Συγγραφείς: Coray R; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain. Electronic address: raffaele.coray@csic.es., Molina-Ribagorda A; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain., Castaño-Díez D; Instituto Biofisika (UPV/EHU, CSIC), University of the Basque Country, Leioa, Spain. Electronic address: daniel.castano@csic.es.

Πηγή: Current opinion in structural biology [Curr Opin Struct Biol] 2026 Oct; Vol. 100, pp. 103319. Date of Electronic Publication: 2026 Jul 01.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: England NLM ID: 9107784 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-033X (Electronic) Linking ISSN: 0959440X NLM ISO Abbreviation: Curr Opin Struct Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Electron Microscope Tomography*/methods , Image Processing, Computer-Assisted*/methods , Cryoelectron Microscopy*/methods , Deep Learning*

Cryo-EM Structure of the C. Elegans Septin Tetramer Reveals a Revised Architecture and Conserved Positional Orthology.

Συγγραφείς: Saladino GCDR; Sao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, Avenida Joao Dagnone, 1100, 13566-590 Sao Carlos, SP, Brazil., Ciol H; Sao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, Avenida Joao Dagnone, 1100, 13566-590 Sao Carlos, SP, Brazil., Mendonça DC; Sao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, Avenida Joao Dagnone, 1100, 13566-590 Sao Carlos, SP, Brazil., Furtado AA; Sao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, Avenida Joao Dagnone, 1100, 13566-590 Sao Carlos, SP, Brazil., Pereira HD; Sao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, Avenida Joao Dagnone, 1100, 13566-590 Sao Carlos, SP, Brazil., Klaholz BP; Centre for Integrative Biology (CBI), Institute of Genetics and Molecular and Cellular Biology, CNRS/Inserm/University of Strasbourg, 67404 Illkirch, France., Ulian Araujo AP; Sao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, Avenida Joao Dagnone, 1100, 13566-590 Sao Carlos, SP, Brazil. Electronic address: anapaula@ifsc.usp.br., Garratt RC; Sao Carlos Institute of Physics, University of Sao Paulo, IFSC - USP, Avenida Joao Dagnone, 1100, 13566-590 Sao Carlos, SP, Brazil. Electronic address: richard@ifsc.usp.br.

Πηγή: Journal of molecular biology [J Mol Biol] 2026 Oct 01; Vol. 438 (19), pp. 169915. Date of Electronic Publication: 2026 Jun 23.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Caenorhabditis elegans*/metabolism , Cryoelectron Microscopy*/methods , Caenorhabditis elegans Proteins*/chemistry , Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans Proteins*/ultrastructure , Septins*/chemistry , Septins*/metabolism , Septins*/genetics , Septins*/ultrastructure, Animals ; Models, Molecular ; Protein Multimerization ; Humans