Εμφανίζονται 1 - 20 Αποτελέσματα από 414.907 για την αναζήτηση '"Computer Science - Machine Learning"', χρόνος αναζήτησης: 1,14δλ Περιορισμός αποτελεσμάτων
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    Academic Journal

    Συγγραφείς: Milenković, Aleksandar1 aleksandar.milenkovic@pmf.kg.ac.rs, Ostojić, Dragutin1 dragutin.ostojic@pmf.kg.ac.rs, Rajković, Dalibor1 d.rajkovicrs@gmail.com, Milikić, Milan2 milikic.milan@yahoo.com

    Πηγή: International Journal of Instruction. Jan2026, Vol. 19 Issue 1, p367-386. 20p.

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    Mixed Materials

    Additional Titles: From the invention of Sanger sequencing, to the birth of current highthroughput and long-read methodologies, sequencing technology has become an vital tool for scientific research. Biologists released the first version of the human genome in 2001, and continued to refine it over the following years until the complete and final genome sequence was published in 2022. In parallel, the 1000 Genome project has revealed the extent of human genetic variation and polymorphisms, filling a gap in our knowledge about the diversity of the human mutational landscape. Transcriptome sequencing provides a means to study the changes in gene expression patterns and related signaling pathways affected by diseases and other biological processes. With the advancement of computer science, machine learning has been introduced into the field of biological and medical research. Using ML approaches scientists hope to find the biological signals and patterns hidden within massive datasets. The first chapter of this thesis provides an overview of the human genome, transcriptome research and different machine learning algorithms, including their applications in biological and medical research. The last chapter centers around two projects I worked on during my Ph.D. In the first project, simply called DNA prediction, we employed a Central model, a Markov model and a bi-directional Markov model to estimate the probability of the occurrence of four nucleotide types at a site based on its context sequence - the input for these models were the human reference genome. The results show that the base prediction of the human genome was above 50% on average, which should be compared to random guessing (25%). We applied the predicted results to SNP databases, and found that the alternative alleles showed higher probabilities than reference bases for somatic SNPs. In addition, we developed a substitution model to calculate the base mutability. Here, we found that the α matrix relies on a much smaller conte

    Συγγραφείς: Liang, Yuhu

    Πηγή: Liang , Y 2023 , ' In pursuit of gene variation of consequence to human health and disease ' .

    Όροι ευρετηρίου: other

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    Mixed Materials

    Additional Titles: From the invention of Sanger sequencing, to the birth of current high-throughput and long-read methodologies, sequencing technology has becomean vital tool for scientific research. Biologists released the first version of thehuman genome in 2001, and continued to refine it over the following yearsuntil the complete and final genome sequence was published in 2022. Inparallel, the 1000 Genome project has revealed the extent of human geneticvariation and polymorphisms, filling a gap in our knowledge about the diver-sity of the human mutational landscape. Transcriptome sequencing providesa means to study the changes in gene expression patterns and related signal-ing pathways affected by diseases and other biological processes. With theadvancement of computer science, machine learning has been introduced intothe field of biological and medical research. Using ML approaches scientistshope to find the biological signals and patterns hidden within massive datasets.The first chapter of this thesis provides an overview of the human genome,transcriptome research and different machine learning algorithms, includingtheir applications in biological and medical research.The last chapter centers around two projects I worked on during my Ph.D.In the first project, simply called DNA prediction, we employed a Centralmodel, a Markov model and a bi-directional Markov model to estimate theprobability of the occurrence of four nucleotide types at a site based on its con-text sequence - the input for these models were the human reference genome.The results show that the base prediction of the human genome was above50% on average, which should be compared to random guessing (25%). Weapplied the predicted results to SNP databases, and found that the alternativealleles showed higher probabilities than reference bases for somatic SNPs. Inaddition, we developed a substitution model to calculate the base mutability.Here, we found that the α matrix relies on a much smaller context sequences,and i

    Συγγραφείς: Liang, Yuhu

    Πηγή: Liang , Y 2023 , ' In pursuit of gene variation of consequence to humanhealth and disease ' .

    Όροι ευρετηρίου: other

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    Academic Journal

    Πηγή: ICASSP 2026 - 2026 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). :6036-6040

    Σύνδεσμος πρόσβασης: http://arxiv.org/abs/2504.19740

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    Academic Journal
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    Academic Journal

    Πηγή: ICASSP 2026 - 2026 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). :6206-6210

    Σύνδεσμος πρόσβασης: http://arxiv.org/abs/2502.07414

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    Academic Journal

    Συγγραφείς: Zihao Wu, Juncheng Dong, Haoming Yang, Vahid Tarokh

    Πηγή: ICASSP 2026 - 2026 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). :1341-1345

    Σύνδεσμος πρόσβασης: http://arxiv.org/abs/2502.11340

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