Factor B as a therapeutic target for the treatment of complement-mediated diseases

Authors: Kavanagh D, Barratt J, Schubart A, Webb NJA, Meier M, Fakhouri F

Source: Front Immunol
Frontiers in Immunology, Vol 16 (2025)
Frontiers in immunology, vol. 16, pp. 1537974

Subject Terms: Immunology, Complement Pathway, Alternative, alternative pathway, therapeutic target, Complement System Proteins, RC581-607, Humans, Complement Factor B/metabolism, Complement Factor B/antagonists & inhibitors, Animals, Complement Activation/drug effects, Complement Inactivating Agents/therapeutic use, Complement Pathway, Alternative/drug effects, Molecular Targeted Therapy, Autoimmune Diseases/immunology, Autoimmune Diseases/drug therapy, Autoimmune Diseases/therapy, complement, factor B, inhibitors, pharmacological treatment, Autoimmune Diseases, Complement Inactivating Agents, Immunologic diseases. Allergy, Complement Activation, Complement Factor B

File Description: application/pdf

Access URL: https://pubmed.ncbi.nlm.nih.gov/40028332
https://doaj.org/article/199de52e05cc41489a690c73482bef7e
https://serval.unil.ch/resource/serval:BIB_72BE2B52468B.P001/REF.pdf
https://serval.unil.ch/notice/serval:BIB_72BE2B52468B
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_72BE2B52468B9

Dietary tryptophan deficiency and its supplementation compromises inflammatory mechanisms and disease resistance in a teleost fish

Authors: M. Machado, R. Azeredo, A. Domingues, S. Fernandez-Boo, J. Dias, L. E. C. Conceição, B. Costas

Contributors: Instituto de Investigação e Inovação em Saúde

Source: Sci Rep

Subject Terms: Tryptophan / deficiency, Erythrocyte Indices, 0301 basic medicine, Blood Bactericidal Activity, Hydrocortisone, Neuroimmunomodulation, Complement Pathway, Alternative, Inflammation / immunology, Fish Diseases / microbiology, Inflammation / genetics, Bass / immunology, Tryptophan / therapeutic use, Article, Hemoglobins / analysis, Peroxidases / blood, Fish Diseases, Hemoglobins, 03 medical and health sciences, Fish Diseases / etiology, Animals, 14. Life underwater, Bass / growth & development, Complement Pathway, Alternative / drug effects, Disease Resistance, Inflammation, Inflammation / blood, 0303 health sciences, Bass / microbiology, Dose-Response Relationship, Drug, Photobacterium, Tryptophan / physiology, Gene Expression Profiling, Body Weight, Nutritional Requirements, Gram-Negative Bacterial Infections / etiology, Tryptophan / administration & dosage, Hydrocortisone / blood, Animal Feed, Blood Cell Count, Immunity, Humoral, Body Weight / drug effects, Bass, Muramidase, Gram-Negative Bacterial Infections / microbiology, Gram-Negative Bacterial Infections, Muramidase / blood

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Access URL: https://www.nature.com/articles/s41598-019-44205-3.pdf
https://pubmed.ncbi.nlm.nih.gov/31118462
https://hdl.handle.net/10216/136337

Immunoglobulin M‐enriched intravenous immunoglobulin inhibits classical pathway complement activation, but not bactericidal activity of human serum

Authors: Walpen, Alexander J, Laumonier, Thomas, Aebi, Christoph, Mohacsi, Paul J, Rieben, Robert

Contributors: BORIS Portal

Source: Xenotransplantation. 11:141-148

Subject Terms: Dextran Sulfate/pharmacology, Cytotoxicity, Immunologic, Graft Rejection, 0301 basic medicine, Blood Bactericidal Activity, Complement Pathway, Alternative/drug effects/immunology, Immunoglobulin M/pharmacology, Complement Pathway, Alternative, Dextran Sulfate, Immunoglobulins, Intravenous, Complement Pathway, Classical/drug effects/immunology, Graft Rejection/blood/immunology, Cell Line, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Blood Bactericidal Activity/drug effects/immunology, Immunoglobulin M, Animals, Humans, Immunoglobulins, Intravenous/pharmacology, Complement Pathway, Classical

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Access URL: https://pubmed.ncbi.nlm.nih.gov/14962276
https://boris-portal.unibe.ch/handle/20.500.12422/105126