Diagnostic interpretation of CFH expression in pan-cancer analyses: the importance of factor H-like 1 isoform resolution.

Συγγραφείς: Clark SJ; Department of Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University of Tübingen, Tübingen, Germany. simon.clark@uni-tuebingen.de.; University Eye Clinic, Eberhard Karls University of Tübingen, Tübingen, Germany. simon.clark@uni-tuebingen.de.; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK. simon.clark@uni-tuebingen.de.

Πηγή: BMC cancer [BMC Cancer] 2026 Oct 11; Vol. 26 (1). Date of Electronic Publication: 2026 Oct 11.

Τύπος έκδοσης: Letter

Στοιχεία περιοδικού: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement Factor H*/genetics , Complement Factor H*/metabolism , Neoplasms*/diagnosis , Neoplasms*/genetics , Neoplasms*/metabolism , Biomarkers, Tumor*/genetics , Biomarkers, Tumor*/metabolism, Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Humans ; Gene Expression Regulation, Neoplastic

Intracellular complement factor H protects neurons during CNS inflammation.

Συγγραφείς: Mayer C; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Woo MS; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sonner JK; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Binkle-Ladisch L; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Fischbach F; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sekol P; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Smith MD; Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lucas-Ruiz F; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Group of Experimental Ophthalmology, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca) and Ophthalmology Department, Universidad de Murcia, Murcia, Spain., Manteufel D; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mattern KM; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Pfeffer LK; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Guo Y; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Siebels B; Section Mass Spectrometry and Proteomics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Miguela A; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Neurodegeneration and Neuroinflammation Group, Girona Biomedical Research Institute (IDIBG-CERCA), Salt, Spain., Vieira V; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Meurs N; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bauer S; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schwarz S; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Wulf S; Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mühlig AK; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; University Children's Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; University Children's Research@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Engler JB; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Conrad M; Institute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg, Germany.; Translational Redox Biology, Technical University of Munich (TUM), TUM Natural School of Sciences, Garching, Germany., Bareyre FM; Institute of Clinical Neuroimmunology, University Hospital LMU Munich, Munich, Germany., Wiech T; Institute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Krasemann S; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Glatzel M; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zipfel PF; Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany., Freiwald T; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Calabresi PA; Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Schirmer L; Division of Neuroimmunology, Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Interdisciplinary Center for Neurosciences, Heidelberg University, Heidelberg, Germany., Friese MA; Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. manuel.friese@zmnh.uni-hamburg.de.; Hamburg Center for Translational Immunology (HCTI), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. manuel.friese@zmnh.uni-hamburg.de.

Πηγή: Nature [Nature] 2026 Oct; Vol. 658 (8136), pp. 765-773. Date of Electronic Publication: 2026 Sep 02.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement Factor H*/metabolism , Complement Factor H*/chemistry , Complement Factor H*/genetics , Retinal Ganglion Cells*/pathology , Retinal Ganglion Cells*/metabolism , Multiple Sclerosis*/pathology , Multiple Sclerosis*/metabolism , Inflammation*/pathology , Inflammation*/metabolism , Central Nervous System*/pathology , Neurons*/metabolism , Neurons*/pathology , Neuroprotection*, Reactive Oxygen Species/metabolism ; Complement C3/metabolism ; Complement C3/deficiency ; Humans ; Animals ; Female ; Mice ; Male ; Oxidative Stress ; Lipid Peroxidation ; Single-Cell Analysis

Glycosylation-based distinction of endogenous and recombinant complement factor H enables selective quantification in human plasma.

Συγγραφείς: Schäfer A; Swiss BioQuant AG, Reinach, Switzerland., Dabrowska-Schlepp P; Eleva GmbH, Freiburg, Germany., Busch A; Eleva GmbH, Freiburg, Germany., Chen JY; Swiss BioQuant AG, Reinach, Switzerland., Wiesener M; Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany., Siethoff C; Swiss BioQuant AG, Reinach, Switzerland.

Πηγή: Bioanalysis [Bioanalysis] 2026 Aug-Aug; Vol. 18 (12-13), pp. 1095-1106. Date of Electronic Publication: 2026 Oct 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101512484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-6199 (Electronic) Linking ISSN: 17576180 NLM ISO Abbreviation: Bioanalysis Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement Factor H*/metabolism , Complement Factor H*/analysis , Complement Factor H*/chemistry, Recombinant Proteins/blood ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Chromatography, High Pressure Liquid/methods ; Tandem Mass Spectrometry/methods ; Humans ; Glycosylation

Using ddPCR to Identify Large Deletions of Complement Factor H-Related Genes in Atypical Hemolytic Uremic Syndrome.

Συγγραφείς: Cheng YW; Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, United States.; Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, United States., Wang Z; Department of Pathology, Cleveland Clinic, Cleveland, OH, United States., Tu ZJ; Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, United States., Mularo F; Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH, United States., Wang X; Center for Personalized Genetic Healthcare, Cleveland Clinic, Cleveland, OH, United States.

Πηγή: The journal of applied laboratory medicine [J Appl Lab Med] 2026 Sep 03; Vol. 11 (5), pp. 1212-1220.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Oxford University Press Country of Publication: England NLM ID: 101693884 Publication Model: Print Cited Medium: Print ISSN: 2576-9456 (Print) Linking ISSN: 24757241 NLM ISO Abbreviation: J Appl Lab Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement C3b Inactivator Proteins*/genetics , Complement Factor H*/genetics , Atypical Hemolytic Uremic Syndrome*/genetics , Blood Proteins*/genetics , Polymerase Chain Reaction*/methods , Gene Deletion*, Multiplex Polymerase Chain Reaction/methods ; Hemolytic-Uremic Syndrome/genetics ; Humans ; DNA Copy Number Variations ; Sequence Deletion ; Apolipoproteins

NUP62 promotes non-small cell lung cancer progression by enhancing STAT4 nuclear translocation to upregulate CFH transcription.

Συγγραφείς: Wu M; Department of Respiratory Medicine, The Fuyang Affiliated Hospital of Anhui Medical University, Fuyang, Anhui Province 236000, China; Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230012, China; Department of Respiratory Medicine, Anhui Public Health Clinical Center, Hefei, Anhui Province 230012, China., Wang X; Department of Respiratory Medicine, The Fuyang Affiliated Hospital of Anhui Medical University, Fuyang, Anhui Province 236000, China., Chai Q; Department of Respiratory Medicine, The Fuyang Affiliated Hospital of Anhui Medical University, Fuyang, Anhui Province 236000, China., Cao X; Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230012, China; Department of Respiratory Medicine, Anhui Public Health Clinical Center, Hefei, Anhui Province 230012, China., Qian K; Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230012, China; Department of Respiratory Medicine, Anhui Public Health Clinical Center, Hefei, Anhui Province 230012, China., Li Y; Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230012, China; Department of Respiratory Medicine, Anhui Public Health Clinical Center, Hefei, Anhui Province 230012, China., Zhao L; Department of Respiratory Medicine, The Fuyang Affiliated Hospital of Anhui Medical University, Fuyang, Anhui Province 236000, China; Department of Respiratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province 230012, China; Department of Respiratory Medicine, Anhui Public Health Clinical Center, Hefei, Anhui Province 230012, China. Electronic address: yfyb10396012@fy.ahmu.edu.cn.

Πηγή: Tissue & cell [Tissue Cell] 2026 Nov; Vol. 103, pp. 103691. Date of Electronic Publication: 2026 Jun 09.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 0214745 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3072 (Electronic) Linking ISSN: 00408166 NLM ISO Abbreviation: Tissue Cell Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/pathology , Complement Factor H*/metabolism , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Membrane Glycoproteins*/metabolism , Nuclear Pore Complex Proteins*/metabolism , STAT4 Transcription Factor*/metabolism, Cell Nucleus/metabolism ; Lung/pathology ; Female ; Humans ; Male ; Mice ; Middle Aged ; A549 Cells ; Disease Progression ; Gene Expression Regulation, Neoplastic ; Mice, Inbred BALB C ; Mice, Nude ; Animals

Complement factor H in cancer biology: intracellular functions, tumor-host interactions, and systemic context.

Συγγραφείς: Wang X; Department of Oncology, Zibo Central Hospital, Zibo, China., Mu M; Department of Oncology, Zibo Central Hospital, Zibo, China., Li H; Department of Oncology, Zibo Central Hospital, Zibo, China.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jul 29; Vol. 17, pp. 1877625. Date of Electronic Publication: 2026 Jul 29 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Neoplasms*/immunology , Neoplasms*/metabolism , Neoplasms*/pathology , Complement Factor H*/immunology , Complement Factor H*/metabolism, Humans ; Animals ; Signal Transduction

ApoE- and Cfh-deficient mice exhibit structural and molecular features of human early-intermediate retinal degeneration.

Συγγραφείς: Recalde S; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research, IdiSNA, Pamplona, Spain., Moreno Orduña M; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain., Bezunartea J; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain., Belza I; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain., Chas A; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain., Fernández-Sánchez L; Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain.; Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, Spain., Cuenca Navarro N; Department of Optics, Pharmacology and Anatomy, University of Alicante, Alicante, Spain.; Department of Physiology, Genetics and Microbiology, University of Alicante, Alicante, Spain., García-Layana A; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research, IdiSNA, Pamplona, Spain., Fernández-Robredo P; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research, IdiSNA, Pamplona, Spain., Hernández M; Retinal Pathologies and New Therapies Group, Experimental Ophthalmology Laboratory, Department of Ophthalmology, Clínica Universidad de Navarra, Pamplona, Spain.; Navarra Institute for Health Research, IdiSNA, Pamplona, Spain.

Πηγή: Animal models and experimental medicine [Animal Model Exp Med] 2026 Jul; Vol. 9 (7), pp. 1420-1435. Date of Electronic Publication: 2026 Jul 01.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101726292 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-2095 (Electronic) Linking ISSN: 25762095 NLM ISO Abbreviation: Animal Model Exp Med Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Apolipoproteins E*/genetics , Apolipoproteins E*/deficiency , Complement Factor H*/deficiency , Complement Factor H*/genetics , Retinal Degeneration*/pathology , Retinal Degeneration*/genetics , Macular Degeneration*/pathology , Macular Degeneration*/genetics, Retinal Pigment Epithelium/pathology ; Retinal Pigment Epithelium/ultrastructure ; Bruch Membrane/pathology ; Retina/pathology ; Animals ; Disease Models, Animal ; Mice ; Mice, Knockout ; Humans ; Lipid Metabolism ; Mice, Inbred C57BL

Complement Factor H-Based Therapeutics: A Comprehensive Overview.

Συγγραφείς: Hamers SMWR; Sanquin Research, Landsteiner Laboratory of the Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Immunology, Amsterdam, the Netherlands., Buter EJ; Sanquin Research, Landsteiner Laboratory of the Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., Pouw RB; Sanquin Research, Landsteiner Laboratory of the Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.; Amsterdam Institute for Immunology and Infectious Diseases, Immunology, Amsterdam, the Netherlands.; Department of Hematology, Amsterdam UMC Location VUmc, Amsterdam, the Netherlands.

Πηγή: European journal of immunology [Eur J Immunol] 2026 Jul; Vol. 56 (7), pp. e70241.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement Factor H*/immunology , Complement Factor H*/therapeutic use, Complement Activation/drug effects ; Complement Activation/immunology ; Complement Pathway, Alternative/drug effects ; Complement Pathway, Alternative/immunology ; Humans ; Animals

Immune complex handling in transplantation: central roles for complement factor H, animal models, and translational implications.

Συγγραφείς: Quigg RJ; Department of Medicine, SUNY University at Buffalo, Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY, United States., Alexander JJ; Department of Medicine, SUNY University at Buffalo, Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY, United States.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jun 15; Vol. 17, pp. 1830799. Date of Electronic Publication: 2026 Jun 15 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement Factor H*/immunology , Complement Factor H*/metabolism , Organ Transplantation*/adverse effects , Antigen-Antibody Complex*/immunology , Antigen-Antibody Complex*/metabolism , Graft Rejection*/immunology, Complement Activation/immunology ; Animals ; Humans ; Translational Research, Biomedical

Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD.

Συγγραφείς: Tang J; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, Tübingen, Germany., Zgoda N; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, Tübingen, Germany., Clark SJ; Institute for Ophthalmic Research, Department for Ophthalmology, Eberhard Karls University of Tübingen, Tübingen, Germany.; University Eye Clinic, Eberhard Karls University of Tübingen, Tübingen, Germany.; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

Πηγή: European journal of immunology [Eur J Immunol] 2026 Jun; Vol. 56 (6), pp. e70228.

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Macular Degeneration*/immunology , Macular Degeneration*/genetics , Complement System Proteins*/immunology , Complement Factor H*/immunology , Complement Factor H*/genetics , Blood Proteins*/genetics , Blood Proteins*/immunology , Blood Proteins*/metabolism, Complement Activation/immunology ; Inflammation/immunology ; Complement C3b Inactivator Proteins/genetics ; Humans ; Animals

Structural mechanisms for the recruitment of factor H by Streptococcus pyogenes.

Συγγραφείς: Kumar A; Department of Biochemistry and Molecular Biophysics, University of California, San Diego, La Jolla, CA 92093, USA., Wang KC; Department of Biochemistry and Molecular Biophysics, University of California, San Diego, La Jolla, CA 92093, USA., Ghosh P; Department of Biochemistry and Molecular Biophysics, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: pghosh@ucsd.edu.

Πηγή: Structure (London, England : 1993) [Structure] 2026 May 07; Vol. 34 (5), pp. 778-789.e4. Date of Electronic Publication: 2026 Mar 16.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Streptococcus pyogenes*/metabolism , Streptococcus pyogenes*/chemistry , Complement Factor H*/metabolism , Complement Factor H*/chemistry , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics, Antigens, Bacterial/metabolism ; Antigens, Bacterial/chemistry ; Protein Binding ; Models, Molecular ; Crystallography, X-Ray ; Binding Sites ; Amino Acid Sequence

Factor H-related proteins as a protective evolutionary mechanism against microbial infections.

Συγγραφείς: García-Sánchez R; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain; Faculty of Medicine, Complutense University, Madrid, Spain., López-Lera A; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER, ISCIII), Madrid, Spain., González-Sánchez L; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER, ISCIII), Madrid, Spain., Corvillo F; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain., Tortajada A; Department of Immunology, Complutense University and Research Institute Hospital 12 de Octubre (imas12), Madrid, Spain., Sánchez-Corral P; Hospital La Paz Institute for Health Research-IdiPAZ, Madrid, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER, ISCIII), Madrid, Spain. Electronic address: Pilar.sanchez-corral@idipaz.es.

Πηγή: Immunobiology [Immunobiology] 2026 May; Vol. 231 (3), pp. 153185. Date of Electronic Publication: 2026 May 05.

Τύπος έκδοσης: Journal Article; Review; Research Support, Non-U.S. Gov't

Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement Factor H*/metabolism , Complement Factor H*/genetics , Complement Factor H*/immunology , Blood Proteins*/genetics , Blood Proteins*/metabolism , Blood Proteins*/immunology, Host-Pathogen Interactions/immunology ; Complement C3b Inactivator Proteins/genetics ; Complement C3b Inactivator Proteins/metabolism ; Humans ; Animals ; Complement Activation ; Evolution, Molecular

A systematic review of short-term outcomes in patients with anti-factor H associated atypical HUS managed with plasma exchanges versus eculizumab.

Συγγραφείς: Sinha A; Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India., Bindal T; Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India., Zotta F; Division of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy., Sellier-Leclerc AL; Department of Pediatric Nephrology, Centre de Référence Des Maladies Rénales Rares Néphrogones, Filières Maladies Rares ORKID Et ERK-Net, CHU de Lyon, Bron, France., Hogan J; Department of Pediatric Nephrology, Reference Center for Thrombotic Microangiopathies, Rare Disease Networks ORKID and ERK-Net, Robert Debré Hospital, APHP, Paris Cité University, Paris, France., Hari P; Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India., Vivarelli M; Division of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.; Clinical Trial Center and Laboratory of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy., Bagga A; Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. arvindbagga@hotmail.com.; Department of Pediatrics, Indraprastha Apollo Hospitals, New Delhi, India. arvindbagga@hotmail.com.

Πηγή: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2026 Dec; Vol. 41 (12), pp. 4369-4378. Date of Electronic Publication: 2026 May 08.

Τύπος έκδοσης: Journal Article; Systematic Review; Comparative Study; Review

Στοιχεία περιοδικού: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Atypical Hemolytic Uremic Syndrome*/therapy , Atypical Hemolytic Uremic Syndrome*/immunology , Antibodies, Monoclonal, Humanized*/therapeutic use , Plasma Exchange*/methods , Complement Factor H*/immunology , Complement Inactivating Agents*/therapeutic use, Combined Modality Therapy/methods ; Immunosuppressive Agents/therapeutic use ; Humans ; Treatment Outcome ; Child ; Remission Induction ; Time Factors

C3 glomerulopathy associated with anti-factor H autoantibodies in a child with inflammatory bowel disease.

Συγγραφείς: Ban M; Division of Pediatric Nephrology, Dialysis and Transplantation, Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia., Matković H; Division of Pediatric Nephrology, Dialysis and Transplantation, Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia., Aničić MN; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia.; Department of Pediatrics, University of Zagreb School of Medicine, Zagreb, Croatia., Ćorić M; Department of Pathology and Cytology, University Hospital Center Zagreb, Zagreb, Croatia.; Department of Pathology, University of Zagreb School of Medicine, Zagreb, Croatia., Prohászka Z; Department of Internal Medicine and Hematology, Semmelweis University, Budapest, Hungary., Lamot L; Division of Pediatric Nephrology, Dialysis and Transplantation, Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia. lovro.lamot@kbc-zagreb.hr.; Department of Pediatrics, University of Zagreb School of Medicine, Zagreb, Croatia. lovro.lamot@kbc-zagreb.hr.

Πηγή: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2026 Nov; Vol. 41 (11), pp. 3899-3902. Date of Electronic Publication: 2026 Jun 16.

Τύπος έκδοσης: Journal Article; Case Reports

Στοιχεία περιοδικού: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Autoantibodies*/immunology , Autoantibodies*/blood , Complement C3*/immunology , Complement C3*/analysis , Complement C3*/metabolism , Complement Factor H*/immunology , Glomerulonephritis, Membranoproliferative*/immunology , Glomerulonephritis, Membranoproliferative*/drug therapy , Glomerulonephritis, Membranoproliferative*/pathology , Inflammatory Bowel Diseases*/immunology , Inflammatory Bowel Diseases*/complications , Inflammatory Bowel Diseases*/drug therapy , Acute Kidney Injury*/immunology , Acute Kidney Injury*/drug therapy , Acute Kidney Injury*/etiology , Glomerulonephritis*/immunology , Glomerulonephritis*/drug therapy , Glomerulonephritis*/pathology, Glucocorticoids/therapeutic use ; Humans ; Male ; Child ; Biopsy

Extended haplotypes at the complement factor H gene locus are associated with liver transplant rejection.

Συγγραφείς: Nieuwenhuis LM; Department of Surgery, Section of Hepatopancreatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Loza BL; Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Berger SP; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Jansen BH; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Blokzijl H; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Daha MR; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Nephrology, Leiden University Medical Center, University of Leiden, Leiden, The Netherlands., Lammerts RGM; Transplantation Immunology, Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Shaked A; Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Asrani S; Baylor University Medical Center, Dallas, Texas, USA., Lisman T; Department of Surgery, Section of Hepatopancreatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Weersma RK; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Festen EAM; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., de Meijer VE; Department of Surgery, Section of Hepatopancreatobiliary Surgery and Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Poppelaars F; Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Συλλογικό Έργο: TransplantLines Investigators

Πηγή: Hepatology communications [Hepatol Commun] 2026 Jul 15; Vol. 10 (8). Date of Electronic Publication: 2026 Jul 15 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101695860 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-254X (Electronic) Linking ISSN: 2471254X NLM ISO Abbreviation: Hepatol Commun Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Liver Transplantation*/adverse effects , Graft Rejection*/genetics , Graft Rejection*/immunology , Complement Factor H*/genetics , Complement C3b Inactivator Proteins*/genetics, Haplotypes ; Humans ; Male ; Female ; Kaplan-Meier Estimate ; Blood Proteins

A case report of atypical hemolytic uremic syndrome with a CFH mutation complicated by recurrent posterior reversible encephalopathy syndrome.

Συγγραφείς: Maruyama R; Department of General Internal Medicine, Aizawa Hospital, Nagano, Japan.; Department of Emergency and Critical Care Medicine, Aizawa Hospital, Nagano, Japan., Takeuchi D; Department of General Internal Medicine, Aizawa Hospital, Nagano, Japan., Momose M; Department of General Internal Medicine, Aizawa Hospital, Nagano, Japan., Amemiya T; Department of General Internal Medicine, Aizawa Hospital, Nagano, Japan., Terakawa I; Department of General Internal Medicine, Aizawa Hospital, Nagano, Japan., Teshima K; Department of General Internal Medicine, Aizawa Hospital, Nagano, Japan., Chimura J; Department of Emergency and Critical Care Medicine, Aizawa Hospital, Nagano, Japan., Noju K; Department of Emergency and Critical Care Medicine, Aizawa Hospital, Nagano, Japan., Sugimoto R; Department of Emergency and Critical Care Medicine, Aizawa Hospital, Nagano, Japan., Shiroto K; Department of Emergency and Critical Care Medicine, Aizawa Hospital, Nagano, Japan., Suganuma K; Department of Emergency and Critical Care Medicine, Aizawa Hospital, Nagano, Japan., Yamamoto T; Department of General Internal Medicine, Aizawa Hospital, Nagano, Japan.

Πηγή: Medicine [Medicine (Baltimore)] 2026 Jul 03; Vol. 105 (27), pp. e49593.

Τύπος έκδοσης: Journal Article; Case Reports

Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Atypical Hemolytic Uremic Syndrome*/genetics , Atypical Hemolytic Uremic Syndrome*/complications , Atypical Hemolytic Uremic Syndrome*/diagnosis , Atypical Hemolytic Uremic Syndrome*/therapy , Complement Factor H*/genetics , Posterior Leukoencephalopathy Syndrome*/genetics , Posterior Leukoencephalopathy Syndrome*/complications , Posterior Leukoencephalopathy Syndrome*/etiology, Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Female ; Adult ; Mutation ; Recurrence

Moss-derived recombinant Factor H, CPV-104, effectively antagonizes alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy.

Συγγραφείς: Imanifard Z; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Penati F; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Padoa S; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Dabrowska-Schlepp P; Department of Nonclinical Development, Eleva GmbH, Freiburg, Germany., Bresin E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Peracchi T; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Benigni A; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Remuzzi G; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Noris M; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy., Donadelli R; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Jul 01; Vol. 17, pp. 1860823. Date of Electronic Publication: 2026 Jul 01 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Complement Pathway, Alternative*/drug effects , Complement Factor H*/pharmacology , Complement C3-C5 Convertases*/metabolism , Bryopsida*/metabolism , Glomerulonephritis, Membranoproliferative*/immunology , Glomerulonephritis, Membranoproliferative*/drug therapy , Complement C3 Convertase, Alternative Pathway*/metabolism, Recombinant Proteins/pharmacology ; Complement C3/metabolism ; Complement C3 Nephritic Factor/metabolism ; Humans ; Female

Association of Complement Genetics with Outcomes in IgA Nephropathy.

Συγγραφείς: Duval A; Inflammation, Complement and Cancer Team, Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université Paris Cité, Paris, France.; Department of Nephrology Dialysis and Transplantation, University Hospital of Strasbourg, Strasbourg, France.; Inserm UMR_1109, Molecular Immuno-Rheumatology, Centre de recherche en biomédecine, Université de Strasbourg, Strasbourg, France., Maillard N; Department of Nephrology Dialysis and Transplantation, University Hospital of Saint Etienne, Saint-Étienne, France.; Groupe sur l'immunité des muqueuses et agents pathogènes, Team 15, CIRI INSERM U1111/UMR5108., Morin M; INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Centrale Nantes, Nantes Université, Nantes, France., El Sissy C; Service d'immunologie biologique, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France., Vieira-Martins P; Service d'immunologie biologique, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France., Durand A; INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Centrale Nantes, Nantes Université, Nantes, France., Roquigny J; Inflammation, Complement and Cancer Team, Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université Paris Cité, Paris, France., Lecerf M; Inflammation, Complement and Cancer Team, Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université Paris Cité, Paris, France., Chauvet S; Inflammation, Complement and Cancer Team, Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université Paris Cité, Paris, France., Olagne J; Department of Nephrology Dialysis and Transplantation, University Hospital of Strasbourg, Strasbourg, France.; Department of Pathology, University Hospital of Strasbourg, Strasbourg, France., Moulin B; Department of Nephrology Dialysis and Transplantation, University Hospital of Strasbourg, Strasbourg, France., Roumenina L; Inflammation, Complement and Cancer Team, Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université Paris Cité, Paris, France., Limou S; INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Centrale Nantes, Nantes Université, Nantes, France., Mariat C; Department of Nephrology Dialysis and Transplantation, University Hospital of Saint Etienne, Saint-Étienne, France.; Groupe sur l'immunité des muqueuses et agents pathogènes, Team 15, CIRI INSERM U1111/UMR5108., Caillard S; Department of Nephrology Dialysis and Transplantation, University Hospital of Strasbourg, Strasbourg, France., Frémeaux-Bacchi V; INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Centrale Nantes, Nantes Université, Nantes, France.

Πηγή: Clinical journal of the American Society of Nephrology : CJASN [Clin J Am Soc Nephrol] 2026 Jul 01; Vol. 21 (7), pp. 1207-1221. Date of Electronic Publication: 2026 May 15.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 101271570 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-905X (Electronic) Linking ISSN: 15559041 NLM ISO Abbreviation: Clin J Am Soc Nephrol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Glomerulonephritis, IGA*/genetics , Glomerulonephritis, IGA*/immunology , Glomerulonephritis, IGA*/complications , Complement Factor H*/genetics , Complement System Proteins*/genetics, Membrane Cofactor Protein/genetics ; Complement Factor B/genetics ; Kidney Failure, Chronic/genetics ; Complement C3/genetics ; Complement Activation/genetics ; Humans ; Adult ; Female ; Male ; Haplotypes ; Middle Aged ; Genetic Predisposition to Disease ; Disease Progression ; Gene Frequency ; Homozygote ; Phenotype

Complement factor H supplementation rather than complete C3 knockout provides therapeutic benefits in IgA nephropathy.

Συγγραφείς: Li X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Ni X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Yuan X; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Wu H; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Shi S; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Liu L; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Lv J; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Zhang H; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China.; Peking University Institute of Nephrology, Beijing, 100034, China.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China., Zhu L; Renal Division, Department of Medicine, Peking University First Hospital, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Peking University Institute of Nephrology, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Renal Disease (Peking University), National Health Commission, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, 100034, China. funnyzhuli@bjmu.edu.cn.; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University and NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing, China. funnyzhuli@bjmu.edu.cn.

Πηγή: Molecular biomedicine [Mol Biomed] 2026 Apr 30; Vol. 7 (1). Date of Electronic Publication: 2026 Apr 30.

Τύπος έκδοσης: Journal Article

Στοιχεία περιοδικού: Publisher: Springer Singapore Country of Publication: Singapore NLM ID: 9918283581406676 Publication Model: Electronic Cited Medium: Internet ISSN: 2662-8651 (Electronic) Linking ISSN: 26628651 NLM ISO Abbreviation: Mol Biomed Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Glomerulonephritis, IGA*/pathology , Glomerulonephritis, IGA*/drug therapy , Glomerulonephritis, IGA*/immunology , Glomerulonephritis, IGA*/genetics , Complement Factor H*/pharmacology , Complement Factor H*/administration & dosage , Complement Factor H*/metabolism , Complement Factor H*/therapeutic use , Complement C3*/deficiency , Complement C3*/genetics , Complement C3*/metabolism, Immunoglobulin A/metabolism ; Immunoglobulin A/immunology ; Macrophages/metabolism ; Macrophages/immunology ; Animals ; Humans ; Mice, Knockout ; Complement Activation ; Mice ; Female ; Disease Models, Animal ; Male

A new perspective on AMD pathogenesis: a sequential Factor H-centered view of complement dysregulation.

Συγγραφείς: Skerka C; Koania Complement Analytics, Hamburg, Germany., Cochlovius B; eleva GmbH, Freiburg, Germany., Hüllebrand JP; eleva GmbH, Freiburg, Germany., Goel D; eleva GmbH, Freiburg, Germany., Sood P; MM Eyetech Institute, Centre for Sight, New Delhi, India., Pal N; The Sight Avenue Hospital, New Delhi, India., Chakravarti A; Aakash Healthcare, New Delhi, India., Muth DR; Division of Eye and Vision, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; St. Erik Eye Hospital, Solna, Sweden.; Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Ophthalmology, Oslo University Hospital, Oslo, Norway., Zeitz O; Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt- Universität zu Berlin and Berlin Institute of Health, Berlin, Germany., Zipfel PF; Koania Complement Analytics, Hamburg, Germany.

Πηγή: Frontiers in immunology [Front Immunol] 2026 Apr 23; Vol. 17, pp. 1814415. Date of Electronic Publication: 2026 Apr 23 (Print Publication: 2026).

Τύπος έκδοσης: Journal Article; Review

Στοιχεία περιοδικού: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Ιατρικοί όροι (MeSH): Macular Degeneration*/immunology , Macular Degeneration*/etiology , Macular Degeneration*/pathology , Macular Degeneration*/metabolism , Macular Degeneration*/genetics , Complement Factor H*/immunology , Complement Factor H*/genetics , Complement Factor H*/metabolism , Complement System Proteins*/immunology, Complement Activation/immunology ; Humans ; Animals ; Complement C3b Inactivator Proteins ; Muscle Proteins ; Intracellular Signaling Peptides and Proteins ; LIM Domain Proteins